Component: Benincasa hispida 冬瓜子


Description of the Component

Component ID
TCMH500
Latin Name
Benincasa hispida
English Name
Chinese waxgourd seed
Chinese Pinyin Name
Dong Gua Zi
中文名
冬瓜子
TCM Properties
TCM Meridians
Therapeutic Class English
Therapeutic Class Chinese
Functions
Toxicity
NA
Geo-authentic habitats (道地产区)
NA
Reference
CFDA
Barcode ID
ITSAJ4250-14
Barcode Source
BOLDSYSTEMS

TCM Prescriptions with the Component

Prescription ID Prescription English Name Prescription Chinese Name
TCMFx4172 Jian Pi Gao Tablets 健脾糕片
TCMF4747 Lan Wei Xiao Yan Pills 阑尾消炎丸
TCMF4738 Lan Wei Xiao Yan Tablets 阑尾消炎片
TCMFx5800 Sheng Ru Tablets 生乳片
TCMFx7116 Xing Pi Kai Wei Granules 醒脾开胃颗粒
TCMFx6181 Xing Pi Kai Wei Infusion 醒脾开胃冲剂

Targeted Human Proteins by the Ingredient of Component

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT1 EHMT2 Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Transferase Q96KQ7
TCMT11 HIF1A Hypoxia-inducible factor 1 alpha Transcription factor Q16665
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT132 BCHE Butyrylcholinesterase Hydrolase P06276
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT143 CA3 Carbonic anhydrase III Lyase P07451
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT158 EPHX2 Epoxide hydratase Lyase P34913
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT176 SOAT1 Acyl coenzyme A:cholesterol acyltransferase 1 Transferase P35610
TCMT18 GAA Lysosomal alpha-glucosidase Hydrolase P10253
TCMT188 DHFR Dihydrofolate reductase Oxidoreductase P00374
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT22 ALPI Intestinal alkaline phosphatase Hydrolase P09923
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT248 CXCL8 Interleukin-8 Unclassified P10145
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT281 DPP4 Dipeptidyl peptidase IV Unclassified P27487
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT307 KCNH2 HERG Ion channel Q12809
TCMT31 CYP2C19 Cytochrome P450 2C19 Oxidoreductase P33261
TCMT311 SLC47A1 Multidrug and toxin extrusion protein 1 Transporter Q96FL8
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT341 NR1I2 Pregnane X receptor Nuclear receptor O75469
TCMT41 IDH1 Isocitrate dehydrogenase [NADP] cytoplasmic Oxidoreductase O75874
TCMT42 KMT2A Histone-lysine N-methyltransferase MLL Transferase Q03164
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT588 DAO D-amino-acid oxidase Oxidoreductase P14920
TCMT6 NFKB1 Nuclear factor NF-kappa-B p105 subunit Transcription factor P19838
TCMT629 ABCC1 Multidrug resistance-associated protein 1 Transporter P33527
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT64 PPARD Peroxisome proliferator-activated receptor delta Nuclear receptor Q03181
TCMT67 PPARG Peroxisome proliferator-activated receptor gamma Nuclear receptor P37231
TCMT69 THRB Thyroid hormone receptor beta-1 Nuclear receptor P10828
TCMT735 RXRA Retinoid X receptor alpha Nuclear receptor P19793
TCMT747 ABCG2 ATP-binding cassette sub-family G member 2 Transporter Q9UNQ0
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT80 MAPK1 MAP kinase ERK2 Kinase P28482
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT81 ALOX12 Arachidonate 12-lipoxygenase Oxidoreductase P18054
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712


Targeted Pathogenic Microbes by the Ingredient of Component

Target ID Target Name
TCMT1092 Fatty acid synthase
TCMT1093 Enoyl-acyl-carrier protein reductase
TCMT1094 3-oxoacyl-acyl-carrier protein reductase
TCMT1099 Neuraminidase
TCMT1104 Sortase
TCMT1108 Integrase
TCMT1136 Neuraminidase
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1183 Candida albicans SC5314
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1212 Verticillium dahliae
TCMT1214 Enterococcus faecium
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1223 Staphylococcus epidermidis
TCMT1229 Enterococcus faecalis
TCMT1251 Candida albicans
TCMT1286 Bacillus cereus
TCMT1310 Enterococcus hirae
TCMT1355 Rhodococcus equi
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Ingredient Structrues

Ingredient ID: TCMC995
Formula: C35H60O6

Ingredient ID: TCMC912
Formula: C15H10O4

Ingredient ID: TCMC801
Formula: C29H50O

Ingredient ID: TCMC795
Formula: C13H16O10

Ingredient ID: TCMC663
Formula: C15H10O5

Ingredient ID: TCMC2806
Formula: C13H12O4

Ingredient ID: TCMC2642
Formula: C17H9NO3

Ingredient ID: TCMC2641
Formula: C21H20O9

Ingredient ID: TCMC2486
Formula: C20H24O9

Ingredient ID: TCMC2344
Formula: C18H18O2

Ingredient ID: TCMC2324
Formula: C10H16

Ingredient ID: TCMC2304
Formula: C27H24O18

Ingredient ID: TCMC2190
Formula: C7H7NO2

Ingredient ID: TCMC2120
Formula: C17H24O9

Ingredient ID: TCMC2105
Formula: C18H36O2

Ingredient ID: TCMC2031
Formula: C27H30O16

Ingredient ID: TCMC2014
Formula: C15H8O6

Ingredient ID: TCMC1889
Formula: C16H12O5

Ingredient ID: TCMC1832
Formula: C16H30O2

Ingredient ID: TCMC1830
Formula: C16H32O2

Ingredient ID: TCMC1788
Formula: C18H34O2

Ingredient ID: TCMC1741
Formula: C6H5NO2

Ingredient ID: TCMC1639
Formula: C18H17NO2

Ingredient ID: TCMC1611
Formula: C14H28O2

Ingredient ID: TCMC1579
Formula: C19H20O2

Ingredient ID: TCMC1523
Formula: C18H18O2

Ingredient ID: TCMC1496
Formula: C18H30O2

Ingredient ID: TCMC1495
Formula: C18H32O2

Ingredient ID: TCMC1334
Formula: C18H18O2

Ingredient ID: TCMC1264
Formula: C5H10N2O3

Ingredient ID: TCMC1203
Formula: C8H8O5

Ingredient ID: TCMC1202
Formula: C7H6O5

Ingredient ID: TCMC1113
Formula: C22H18O10

Ingredient ID: TCMC1105
Formula: C15H10O5

Properties

Ingredient ID Formulae Name MW AlogP MlogP XlogP # HBA # HBD PSA # Rotatable Bond # Ring # Heacy Atom Lipinski RO5 Violation
TCMC663 C15H10O5 Aloe-Emodin 270.05 -1.8969 2.56 0.284 3 3 94.83 4 3 20 0
TCMC795 C13H16O10 Beta-Glucogallin 332.07 -3.5251 1.79 -1.304 7 7 177.14 11 2 23 1
TCMC801 C29H50O Beta-Sitosterol 414.39 1.3 4.54 11.595 1 1 20.23 13 4 30 1
TCMC912 C15H10O4 Chrysophanol 254.06 -0.8062 2.67 1.627 2 2 74.6 3 3 19 0
TCMC995 C35H60O6 Daucosterol 576.44 -0.4469 4.65 10.487 6 4 99.38 19 5 41 1
TCMC1105 C15H10O5 Emodin 270.05 -1.2665 2.56 0.664 2 3 94.83 4 3 20 0
TCMC1113 C22H18O10 Epicatechin Gallate 442.09 -3.5057 2.78 1.228 2 7 177.14 11 4 32 1
TCMC1202 C7H6O5 Gallic Acid 170.02 -1.6207 1.68 0.002 2 4 97.99 5 1 12 0
TCMC1203 C8H8O5 Gallic Acid Methyl Ester 184.04 -1.3697 1.79 0.323 2 3 86.99 6 1 13 0
TCMC1264 C5H10N2O3 Glutamine 146.07 -1.4816 1.46 -2.943 5 4 107.4 7 0 10 0
TCMC1334 C18H18O2 Honokiol 266.13 1.1368 3.22 5.024 0 2 40.46 7 2 20 1
TCMC1495 C18H32O2 Linoleic Acid 280.24 -0.9485 3.22 7.865 2 1 37.3 16 0 20 2
TCMC1496 C18H30O2 Linolenic Acid 278.22 -0.0979 3.22 7.538 2 1 37.3 15 0 20 2
TCMC1523 C18H18O2 Magnolol 266.13 1.1368 3.22 5.446 0 2 40.46 7 2 20 1
TCMC1579 C19H20O2 Methylhonokiol 280.15 1.5453 3.33 5.543 0 1 29.46 8 2 21 1
TCMC1611 C14H28O2 Myristic Acid 228.21 -3.3217 2.78 6.432 2 1 37.3 14 0 16 2
TCMC1639 C18H17NO2 279.13 0.092 3.11 3.896 1 0 21.7 1 5 21 0
TCMC1741 C6H5NO2 Niacin 123.03 -0.2398 1.79 0.637 3 1 50.19 2 1 9 0
TCMC1788 C18H34O2 Oleic Acid 282.26 -2.3427 3.22 8.192 2 1 37.3 17 0 20 2
TCMC1830 C16H32O2 Palmitic Acid 256.24 -3.8977 3 7.57 2 1 37.3 16 0 18 2
TCMC1832 C16H30O2 Palmitoleic Acid 254.22 -1.7667 3 7.054 2 1 37.3 15 0 18 2
TCMC1889 C16H12O5 Physcion 284.07 -0.858 2.67 1.183 2 2 83.83 5 3 21 0
TCMC2014 C15H8O6 Rhein 284.03 -1.688 2.45 0.541 4 3 111.9 4 3 21 0
TCMC2031 C27H30O16 Rutin 610.15 -6.139 2.67 -1.188 11 10 265.52 17 5 43 2
TCMC2105 C18H36O2 Stearic Acid 284.27 -4.4737 3.22 8.708 2 1 37.3 18 0 20 2
TCMC2120 C17H24O9 Syringin 372.14 -2.2917 2.34 -0.417 6 5 138.07 14 2 26 0
TCMC2190 C7H7NO2 Trigonelline 137.05 -2.2592 1.9 0.283 2 0 44.01 3 1 10 0
TCMC2304 C27H24O18 1,2,6-Tri-O-Galloyl-Beta-D-Glucose 636.1 -5.5485 2.45 -0.518 9 11 310.66 21 4 45 1
TCMC2324 C10H16 Limonene 136.13 2.1424 2.56 3.729 0 0 0 3 1 10 0
TCMC2344 C18H18O2 Isomagnolol 266.13 1.443 3.22 6.122 0 1 29.46 7 2 20 1
TCMC2486 C20H24O9 Torachrysone 8-O-Glucoside 408.14 -2.3312 2.67 0.815 6 5 145.91 13 3 29 0
TCMC2641 C21H20O9 Pulmatin 416.11 -2.5531 2.78 0.519 7 5 153.75 9 4 30 0
TCMC2642 C17H9NO3 Liriodenine 275.06 -0.5665 2.89 3.275 2 0 48.42 0 5 21 0
TCMC2806 C13H12O4 5-Acetonyl-7-Hydroxy-2-Methylchromone 232.07 -0.7435 2.45 0.874 2 1 63.6 5 2 17 0

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1. General Information of the Component  
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3. Putative Targets  
4. Activity & References for Filtering Putative Targets  
5. Ingredient Data & Chemical Structure Information (Properties, InChI, InChIkey, SMILES, etc.)