Component: Rheum officinale 大黄流浸膏

Description of the Component

Component ID
Latin Name
Rheum officinale
English Name
Medicinal rhubarb
Chinese Pinyin Name
Da Huang Liu Jin Gao
TCM Properties
TCM Meridians
Therapeutic Class English
Therapeutic Class Chinese
Geo-authentic habitats (道地产区)
Barcode ID
Barcode Source

TCM Prescriptions with the Component

Prescription ID Prescription English Name Prescription Chinese Name
TCMFx4392 Meng Shi Gun Tan Tablets 礞石滚痰片

Targeted Human Proteins by the Ingredient of Component

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT1 EHMT2 Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Transferase Q96KQ7
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT11 HIF1A Hypoxia-inducible factor 1 alpha Transcription factor Q16665
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT125 GBA Beta-glucocerebrosidase Hydrolase P04062
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT132 BCHE Butyrylcholinesterase Hydrolase P06276
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT143 CA3 Carbonic anhydrase III Lyase P07451
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT158 EPHX2 Epoxide hydratase Lyase P34913
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT166 AKR1C2 Aldo-keto reductase family 1 member C2 Oxidoreductase P52895
TCMT167 AKR1C3 Aldo-keto-reductase family 1 member C3 Oxidoreductase P42330
TCMT168 AKR1C4 Aldo-keto reductase family 1 member C4 Oxidoreductase P17516
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT18 GAA Lysosomal alpha-glucosidase Hydrolase P10253
TCMT186 MAOB Monoamine oxidase B Oxidoreductase P27338
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT188 DHFR Dihydrofolate reductase Oxidoreductase P00374
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT195 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 Kinase Q02750
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT22 ALPI Intestinal alkaline phosphatase Hydrolase P09923
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT225 CA13 Carbonic anhydrase XIII Lyase Q8N1Q1
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT230 HSD17B3 Estradiol 17-beta-dehydrogenase 3 Oxidoreductase P37058
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT248 CXCL8 Interleukin-8 Unclassified P10145
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT265 GSK3B Glycogen synthase kinase-3 beta Kinase P49841
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT276 SLCO2B1 Solute carrier organic anion transporter family member 2B1 Transporter O94956
TCMT277 SLCO1B3 Solute carrier organic anion transporter family member 1B3 Transporter Q9NPD5
TCMT278 SLCO1B1 Solute carrier organic anion transporter family member 1B1 Transporter Q9Y6L6
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT31 CYP2C19 Cytochrome P450 2C19 Oxidoreductase P33261
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT314 HTR2C Serotonin 2c (5-HT2c) receptor GPCR P28335
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT316 MTNR1A Melatonin receptor 1A GPCR P48039
TCMT317 MTNR1B Melatonin receptor 1B GPCR P49286
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT41 IDH1 Isocitrate dehydrogenase [NADP] cytoplasmic Oxidoreductase O75874
TCMT42 KMT2A Histone-lysine N-methyltransferase MLL Transferase Q03164
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT564 PRMT1 Protein-arginine N-methyltransferase 1 Transferase Q99873
TCMT59 BCL2L1 Apoptosis regulator Bcl-X Ion channel Q07817
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT6 NFKB1 Nuclear factor NF-kappa-B p105 subunit Transcription factor P19838
TCMT60 FASN Fatty acid synthase Unclassified P49327
TCMT601 F2 Thrombin Unclassified P00734
TCMT609 CTSL Cathepsin L Unclassified P07711
TCMT629 ABCC1 Multidrug resistance-associated protein 1 Transporter P33527
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT644 HTR3A Serotonin 3a (5-HT3a) receptor Ion channel P46098
TCMT645 HTR1E Serotonin 1e (5-HT1e) receptor GPCR P28566
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT69 THRB Thyroid hormone receptor beta-1 Nuclear receptor P10828
TCMT714 ODC1 Ornithine decarboxylase Lyase P11926
TCMT726 BCR Bcr/Abl fusion protein Kinase P11274
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT735 RXRA Retinoid X receptor alpha Nuclear receptor P19793
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT747 ABCG2 ATP-binding cassette sub-family G member 2 Transporter Q9UNQ0
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT80 MAPK1 MAP kinase ERK2 Kinase P28482
TCMT81 ALOX12 Arachidonate 12-lipoxygenase Oxidoreductase P18054
TCMT815 HTR1D Serotonin 1d (5-HT1d) receptor GPCR P28221
TCMT816 HTR1B Serotonin 1b (5-HT1b) receptor GPCR P28222
TCMT817 HTR4 Serotonin 4 (5-HT4) receptor GPCR Q13639
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT95 MPG DNA-3-methyladenine glycosylase Hydrolase P29372

Targeted Pathogenic Microbes by the Ingredient of Component

Target ID Target Name
TCMT1086 Isocitrate lyase
TCMT1090 Human immunodeficiency virus type 1 integrase
TCMT1092 Fatty acid synthase
TCMT1093 Enoyl-acyl-carrier protein reductase
TCMT1094 3-oxoacyl-acyl-carrier protein reductase
TCMT1099 Neuraminidase
TCMT1104 Sortase
TCMT1108 Integrase
TCMT1136 Neuraminidase
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1182 Streptococcus sanguinis
TCMT1183 Candida albicans SC5314
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1229 Enterococcus faecalis
TCMT1246 Escherichia coli
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1286 Bacillus cereus
TCMT1438 Plasmodium falciparum
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Ingredient Structrues

Ingredient ID: TCMC995
Formula: C35H60O6

Ingredient ID: TCMC921
Formula: C14H12O3

Ingredient ID: TCMC916
Formula: C9H8O2

Ingredient ID: TCMC913
Formula: C15H14O6

Ingredient ID: TCMC912
Formula: C15H10O4

Ingredient ID: TCMC879
Formula: C22H18O10

Ingredient ID: TCMC878
Formula: C15H14O6

Ingredient ID: TCMC847
Formula: C9H8O4

Ingredient ID: TCMC841
Formula: C10H10O

Ingredient ID: TCMC795
Formula: C13H16O10

Ingredient ID: TCMC756
Formula: C21H18O11

Ingredient ID: TCMC755
Formula: C15H10O5

Ingredient ID: TCMC741
Formula: C14H8O4

Ingredient ID: TCMC706
Formula: C14H8O2

Ingredient ID: TCMC704
Formula: C14H8O4

Ingredient ID: TCMC665
Formula: C21H22O9

Ingredient ID: TCMC664
Formula: C21H22O9

Ingredient ID: TCMC663
Formula: C15H10O5

Ingredient ID: TCMC548
Formula: C28H34O15

Ingredient ID: TCMC416
Formula: C22H18O10

Ingredient ID: TCMC4
Formula: C22H18O10

Ingredient ID: TCMC3
Formula: C15H14O6

Ingredient ID: TCMC2806
Formula: C13H12O4

Ingredient ID: TCMC2699
Formula: C25H24O11

Ingredient ID: TCMC2641
Formula: C21H20O9

Ingredient ID: TCMC255
Formula: C15H12O4

Ingredient ID: TCMC2486
Formula: C20H24O9

Ingredient ID: TCMC24
Formula: C15H14O6

Ingredient ID: TCMC2355
Formula: C14H14O4

Ingredient ID: TCMC2304
Formula: C27H24O18

Ingredient ID: TCMC2063
Formula: C10H12N2O

Ingredient ID: TCMC2061
Formula: C42H38O20

Ingredient ID: TCMC2031
Formula: C27H30O16

Ingredient ID: TCMC2014
Formula: C15H8O6

Ingredient ID: TCMC2004
Formula: C15H14O3

Ingredient ID: TCMC2003
Formula: C14H12O3

Ingredient ID: TCMC1990
Formula: C14H8O6

Ingredient ID: TCMC1967
Formula: C14H8O5

Ingredient ID: TCMC1892
Formula: C14H12O4

Ingredient ID: TCMC1890
Formula: C28H32O15

Ingredient ID: TCMC1889
Formula: C16H12O5

Ingredient ID: TCMC182
Formula: C9H8O4

Ingredient ID: TCMC179
Formula: C30H28O8

Ingredient ID: TCMC1735
Formula: C27H32O14

Ingredient ID: TCMC1523
Formula: C18H18O2

Ingredient ID: TCMC143
Formula: C42H38O20

Ingredient ID: TCMC1334
Formula: C18H18O2

Ingredient ID: TCMC1321
Formula: C28H34O15

Ingredient ID: TCMC13
Formula: C15H14O6

Ingredient ID: TCMC1281
Formula: C42H62O16

Ingredient ID: TCMC1264
Formula: C5H10N2O3

Ingredient ID: TCMC1203
Formula: C8H8O5

Ingredient ID: TCMC1202
Formula: C7H6O5

Ingredient ID: TCMC1173
Formula: C10H10O4

Ingredient ID: TCMC1113
Formula: C22H18O10

Ingredient ID: TCMC1106
Formula: C15H12O4

Ingredient ID: TCMC1105
Formula: C15H10O5

Ingredient ID: TCMC1080
Formula: C20H38O7S


Ingredient ID Formulae Name MW AlogP MlogP XlogP # HBA # HBD PSA # Rotatable Bond # Ring # Heacy Atom Lipinski RO5 Violation
TCMC3 C15H14O6 (-)-Catechin 290.08 -2.494 2.45 0.406 1 5 110.38 6 3 21 0
TCMC4 C22H18O10 (-)-Catechingallate 442.09 -3.5057 2.78 1.228 2 7 177.14 11 4 32 1
TCMC13 C15H14O6 (-)-Epicatechin 290.08 -2.494 2.45 0.406 1 5 110.38 6 3 21 0
TCMC24 C15H14O6 (+)-Epicatechin 290.08 -2.494 2.45 0.406 1 5 110.38 6 3 21 0
TCMC143 C42H38O20 (9R)-9-[(9R)-2-Carboxy-4-Hydroxy-10-Oxo-5-[(3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Oxan-2-Yl]Oxy-9H-Anthracen-9-Yl]-4-Hydroxy-10-Oxo-5-[(2S,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Oxan-2-Yl]Oxy-9H-Anthracene-2-Carboxylic Acid 862.2 -6.3452 3.88 0.662 16 12 347.96 21 8 62 2
TCMC179 C30H28O8 (Z)-1-[6-[(3-Acetyl-2,4,6-Trihydroxy-5-Methylphenyl)Methyl]-5,7-Dihydroxy-2,2-Dimethylchromen-8-Yl]-3-Phenylprop-2-En-1-One 516.18 -0.4521 3.88 5.124 2 5 144.52 15 4 38 1
TCMC182 C9H8O4 (Z)-3-(3,4-Dihydroxyphenyl)Prop-2-Enoic Acid 180.04 -0.7993 2.01 1.141 2 3 77.76 5 1 13 0
TCMC255 C15H12O4 1,8-Dihydroxy-3-Methyl-4A,9A-Dihydroanthracene-9,10-Dione 256.07 -0.4584 2.67 0.487 3 2 74.6 3 3 19 0
TCMC416 C22H18O10 3,4,5-Trihydroxy-Benzoic Acid (2S,3S)-2-(3,4-Dihydroxy-Phenyl)-5,7-Dihydroxy-Chroman-3-Yl Ester 442.09 -3.5057 2.78 1.228 2 7 177.14 11 4 32 1
TCMC548 C28H34O15 5-Hydroxy-2-(3-Hydroxy-4-Methoxyphenyl)-7-[3,4,5-Trihydroxy-6-[(3,4,5-Trihydroxy-6-Methyloxan-2-Yl)Oxymethyl]Oxan-2-Yl]Oxy-2,3-Dihydrochromen-4-One 610.19 -4.86 2.89 -1.489 10 8 234.29 17 5 43 1
TCMC663 C15H10O5 Aloe-Emodin 270.05 -1.8969 2.56 0.284 3 3 94.83 4 3 20 0
TCMC664 C21H22O9 Aloin 418.13 -3.9997 2.78 -0.688 7 7 167.91 10 4 30 1
TCMC665 C21H22O9 Aloin B 418.13 -3.9997 2.78 -0.688 7 7 167.91 10 4 30 1
TCMC704 C14H8O4 Anthraflavicacid 240.04 -1.4482 2.56 1.304 2 2 74.6 2 3 18 0
TCMC706 C14H8O2 Anthraquinone 208.05 -0.5276 2.78 4.074 2 0 34.14 0 3 16 0
TCMC741 C14H8O4 Athraquinones A 240.04 -1.4482 2.56 2.155 2 2 74.6 2 3 18 0
TCMC755 C15H10O5 Baicalein 270.05 -1.8845 2.56 3.058 1 3 86.99 4 3 20 0
TCMC756 C21H18O11 Baicalin 446.08 -3.5292 2.56 1.678 7 6 183.21 10 4 32 1
TCMC795 C13H16O10 Beta-Glucogallin 332.07 -3.5251 1.79 -1.304 7 7 177.14 11 2 23 1
TCMC841 C10H10O Butenone 146.07 0.1072 2.45 4.166 1 0 17.07 3 1 11 0
TCMC847 C9H8O4 Caffeic Acid 180.04 -0.7993 2.01 1.141 2 3 77.76 5 1 13 0
TCMC878 C15H14O6 Catechin 290.08 -2.494 2.45 0.406 1 5 110.38 6 3 21 0
TCMC879 C22H18O10 Catechin Gallate 442.09 -3.5057 2.78 1.228 2 7 177.14 11 4 32 1
TCMC912 C15H10O4 Chrysophanol 254.06 -0.8062 2.67 1.627 2 2 74.6 3 3 19 0
TCMC913 C15H14O6 Cianidanol 290.08 -2.494 2.45 0.406 1 5 110.38 6 3 21