Component: Tripterygium wilfordii 雷公藤


Description of the Component

Component ID
TCMH1255
Latin Name
Tripterygium wilfordii
English Name
Common threewingnut
Chinese Pinyin Name
Lei Gong Teng
中文名
雷公藤
TCM Properties
Cold,Bitter
TCM Meridians
Liver,Heart
Therapeutic Class English
For dispelling wind-dampness
Therapeutic Class Chinese
祛风湿
Functions
expel wind-dampness, relieve swelling, alleviate pain and dredge the meridian passage
Toxicity
Slightly Toxic
Geo-authentic habitats (道地产区)
NA
Reference
SATCM
Barcode ID
ITSAJ4592-14
Barcode Source
BOLDSYSTEMS

TCM Prescriptions with the Component

Prescription ID Prescription English Name Prescription Chinese Name
TCMFx1966 Combination LGT Fries Recipe 复方雷公藤煎剂

Targeted Human Proteins by the Ingredient of Component

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT1 EHMT2 Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Transferase Q96KQ7
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT186 MAOB Monoamine oxidase B Oxidoreductase P27338
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT265 GSK3B Glycogen synthase kinase-3 beta Kinase P49841
TCMT276 SLCO2B1 Solute carrier organic anion transporter family member 2B1 Transporter O94956
TCMT277 SLCO1B3 Solute carrier organic anion transporter family member 1B3 Transporter Q9NPD5
TCMT278 SLCO1B1 Solute carrier organic anion transporter family member 1B1 Transporter Q9Y6L6
TCMT281 DPP4 Dipeptidyl peptidase IV Unclassified P27487
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT41 IDH1 Isocitrate dehydrogenase [NADP] cytoplasmic Oxidoreductase O75874
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT80 MAPK1 MAP kinase ERK2 Kinase P28482


Targeted Pathogenic Microbes by the Ingredient of Component

Target ID Target Name
TCMT1218 Staphylococcus aureus
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1438 Plasmodium falciparum
TCMT1454 Bacillus subtilis
TCMT1465 Entamoeba histolytica

Ingredient Structrues

Ingredient ID: TCMC909
Formula: C17H14O4

Ingredient ID: TCMC882
Formula: C29H38O4

Ingredient ID: TCMC823
Formula: C17H14O4

Ingredient ID: TCMC801
Formula: C29H50O

Ingredient ID: TCMC7084
Formula: C20H31NO2

Ingredient ID: TCMC6849
Formula: C20H26O7

Ingredient ID: TCMC6733
Formula: C30H48O4

Ingredient ID: TCMC5866
Formula: C21H28O5

Ingredient ID: TCMC5865
Formula: C28H42O5

Ingredient ID: TCMC5259
Formula: C38H47NO18

Ingredient ID: TCMC5023
Formula: C28H36O4

Ingredient ID: TCMC4922
Formula: C31H48O2

Ingredient ID: TCMC4921
Formula: C30H48O4

Ingredient ID: TCMC4920
Formula: C30H48O4

Ingredient ID: TCMC4919
Formula: C21H30O4

Ingredient ID: TCMC4918
Formula: C20H28O2

Ingredient ID: TCMC4917
Formula: C20H22O4

Ingredient ID: TCMC4916
Formula: C31H50O4

Ingredient ID: TCMC4915
Formula: C20H26O3

Ingredient ID: TCMC4914
Formula: C21H28O3

Ingredient ID: TCMC4913
Formula: C20H24O6

Ingredient ID: TCMC4894
Formula: C34H36N2O8

Ingredient ID: TCMC4846
Formula: C31H50O4

Ingredient ID: TCMC4845
Formula: C31H48O4

Ingredient ID: TCMC4672
Formula: C41H47NO20

Ingredient ID: TCMC4663
Formula: C21H26O4

Ingredient ID: TCMC4544
Formula: C20H26O7

Ingredient ID: TCMC4526
Formula: C30H46O4

Ingredient ID: TCMC4495
Formula: C20H28O2

Ingredient ID: TCMC4492
Formula: C30H46O3

Ingredient ID: TCMC4481
Formula: C30H48O4

Ingredient ID: TCMC4464
Formula: C25H31N3O2

Ingredient ID: TCMC4463
Formula: C21H27N3O3

Ingredient ID: TCMC4462
Formula: C25H31N3O2

Ingredient ID: TCMC4436
Formula: C30H44O3

Ingredient ID: TCMC4435
Formula: C39H45NO19

Ingredient ID: TCMC4272
Formula: C30H48O4

Ingredient ID: TCMC4270
Formula: C30H48O4

Ingredient ID: TCMC4268
Formula: C21H24O7

Ingredient ID: TCMC4267
Formula: C23H29N3O2

Ingredient ID: TCMC4265
Formula: C20H24O3

Ingredient ID: TCMC4261
Formula: C20H24O7

Ingredient ID: TCMC3799
Formula: C20H22O6

Ingredient ID: TCMC3767
Formula: C21H26O3

Ingredient ID: TCMC3760
Formula: C20H24O7

Ingredient ID: TCMC3747
Formula: C30H50O

Ingredient ID: TCMC3733
Formula: C20H24O6

Ingredient ID: TCMC3709
Formula: C13H16O3

Ingredient ID: TCMC3466
Formula: C20H24O7

Ingredient ID: TCMC3456
Formula: C15H10O5

Ingredient ID: TCMC338
Formula: C8H8O4

Ingredient ID: TCMC3372
Formula: C22H26O8

Ingredient ID: TCMC2809
Formula: C15H18O

Ingredient ID: TCMC1735
Formula: C27H32O14

Properties

Ingredient ID Formulae Name MW AlogP MlogP XlogP # HBA # HBD PSA # Rotatable Bond # Ring # Heacy Atom Lipinski RO5 Violation
TCMC338 C8H8O4 2,6-Dimethoxyquinone 168.04 -0.8026 1.9 0.252 4 0 52.6 4 1 12 0
TCMC801 C29H50O Beta-Sitosterol 414.39 1.3 4.54 11.595 1 1 20.23 13 4 30 1
TCMC823 C17H14O4 Bonducellin 282.09 -0.6462 2.89 3.016 1 1 55.76 4 3 21 0
TCMC882 C29H38O4 Celastrol 450.28 2.4831 4.21 7.98 4 2 74.6 9 5 33 1
TCMC909 C17H14O4 Chrysin Dimethyl Ether 282.09 -0.6072 2.89 4.201 1 0 44.76 5 3 21 0
TCMC1735 C27H32O14 Naringin 580.18 -4.8082 2.89 -1.045 10 8 225.06 15 5 41 1
TCMC2809 C15H18O 7-Hydroxycadalin 214.14 1.3966 3 5.755 0 1 20.23 6 2 16 1
TCMC3372 C22H26O8 Syringaresinol 418.1627678 -2.1258 3 0.796 2 2 95.84 6 4 30 0
TCMC3456 C15H10O5 1,8-Dihydroxy-4-Hydroxymethyl Anthraquinone 270.0528234 -1.8969 2.56 0.284 3 3 94.83 1 3 20 0
TCMC3466 C20H24O7 16-Hydroxytriptolide 376.1522031 -1.7754 2.89 -1.139 7 2 104.35 2 7 27 0
TCMC3709 C13H16O3 Wilforonide 220.1099444 0.3246 2.56 0.85 3 0 43.37 0 3 16 0
TCMC3733 C20H24O6 Tripdioltonide 360.1572885 -0.8271 3 -0.762 6 2 96.36 1 5 26 0
TCMC3747 C30H50O Euonymine 426.3861662 3.2175 4.65 12.613 1 0 17.07 0 5 31 1
TCMC3760 C20H24O7 Tripdiolide 376.1522033 -1.4603 2.89 -0.771 7 2 104.35 1 7 27 0
TCMC3767 C21H26O3 Hypolide 326.1881947 1.1023 3.44 4.915 2 0 35.53 2 4 24 0
TCMC3799 C20H22O6 Triptonide 358.1416384 -0.6403 3 -0.498 6 0 80.96 1 7 26 0
TCMC4261 C20H24O7 Triptolidenol 376.1522033 -1.3263 2.89 -0.488 7 2 104.35 1 7 27 0
TCMC4265 C20H24O3 Triptophenolide 312.1725446 0.6938 3.33 4.396 2 1 46.53 1 4 23 0
TCMC4267 C23H29N3O2 Celabenzine 380.2338022 -3.5467 3.44 5.463 4 2 66.02 3 3 28 1
TCMC4268 C21H24O7 (+)-Medioresinol 388.1522031 -2.074 3 1.24 2 2 86.61 5 4 28 0
TCMC4270 C30H48O4 Salaspermic Acid 471.347435 0.2127 4.32 8.726 4 1 69.59 1 6 34 1
TCMC4272 C30H48O4 Triptotriterpenic Acid A 471.347435 0.8789 4.32 6.486 4 2 80.59 1 5 34 1
TCMC4435 C39H45NO19 Wilfordconine 831.2585782 -2.93 3.55 0.577 19 3 280.05 12 6 59 2
TCMC4436 C30H44O3 Wilforlide B 452.3290453 2.7354 4.43 7.18 3 0 43.37 0 6 33 1
TCMC4462 C25H31N3O2 Celacinnine 406.2494523 -3.1856 3.66 6.701 4 2 66.02 4 3 30 1
TCMC4463 C21H27N3O3 Celafurine 370.2130668 -3.7008 3.11 3.052 4 2 79.16 3 3 27 0
TCMC4464 C25H31N3O2 Celallocinnine 406.2494523 -3.1856 3.66 6.701 4 2 66.02 4 3 30 1
TCMC4481 C30H48O4 Abrusgenic Acid 471.347435 0.8789 4.32 6.486 4 2 80.59 1 5 34 1
TCMC4492 C30H46O3 Abruslactone A 454.3446953 2.1657 4.43 7.787 3 1 46.53 0 6 33 1
TCMC4495 C20H28O2 Dehydroabietic Acid 299.2011051 0.2236 3.44 7.465 2 0 40.13 2 3 22 1
TCMC4526 C30H46O4 3,24-Dioxo-Fridelan-29-Oic Acid 469.3317849 0.8235 4.32 7.98 4 0 74.27 2 5 34 1
TCMC4544 C20H26O7 13,14-Epoxide 9,11,12-Hydroxytriptolide 378.1678532 -1.6537 2.89 -0.167 7 3 112.05 1 6 27 0
TCMC4663 C21H26O4 Isoneotriptophenolide 342.1831093 0.642 3.33 3.741 2 1 55.76 2 4 25 0
TCMC4672 C41H47NO20 Isowilfortrine 873.2691429 -2.5509 3.66 1.317 20 2 286.12 14 6 62 2
TCMC4845 C31H48O4 Regelin D 484.35526 2.3774 4.43 6.681 4 1 63.6 2 5 35 1
TCMC4846 C31H50O4 Regelindiol A 486.3709101 1.5256 4.43 7.595 4 2 66.76 2 5 35 1
TCMC4894 C34H36N2O8 4Α-Hydroxy-1Β,2Β,5Α-Triacetoxy-7Β,11-Diisobutyryloxy-8Α-Furanoyl-Dihydroagarofuran 600.2471661 -0.3858 4.1 6.36 10 1 134.14 9 6 44 1
TCMC4913 C20H24O6 Tripdiotolnide 360.1572885 -0.8271 3 -0.762 6 2 96.36 1 5 26 0
TCMC4914 C21H28O3 Triptinin A 327.1960197 0.9062 3.44 5.073 2 0 49.36 3 3 24 1
TCMC4915 C20H26O3 Triptinin B 313.1803697 0.4977 3.33 4.554 2 1 60.36 2 3 23 0
TCMC4916 C31H50O4 Triptodihydroxy Acid Methyl Ester 486.3709101 1.2901 4.43 8.241 4 2 66.76 3 5 35 1
TCMC4917 C20H22O4 Triptonolide 326.1518092 0.1468 3.22 3.112 3 1 63.6 1 4 24 0
TCMC4918 C20H28O2 Triptonoterpene 300.2089301 1.3195 3.44 4.886 1 1 37.3 1 3 22 0
TCMC4919 C21H30O4 Triptonoterpenol 346.2144094 0.177 3.33 3.317 2 2 66.76 3 3 25 0
TCMC4920 C30H48O4 Triptotriterpenic Acid B 471.347435 0.8789 4.32 6.486 4 2 80.59 1 5 34 1
TCMC4921 C30H48O4 Triptotriterpenic Acid C 471.347435 0.5968 4.32 6.793 4 2 80.59 1 5 34 1
TCMC4922 C31H48O2 Triptotriterpenoidel Lactone A 452.3654308 2.0309 4.65 8.6 2 1 37.3 0 6 33 1
TCMC5023 C28H36O4 Celastrol 435.2535346 1.3589 4.1 7.318 4 1 77.43 1 5 32 1
TCMC5259 C38H47NO18 Euonine 805.2793137 -1.4086 3.55 1.946 19 1 252.75 13 5 57 2
TCMC5865 C28H42O5 5Α-Hydroxytriptonide 458.3032244 0.2596 3.99 5 5 3 94.83 0 5 33 0
TCMC5866 C21H28O5 16-Hydroxytriptobenzene H 359.185849 -0.4423 3.22 2.134 3 2 89.82 4 3 26 0
TCMC6733 C30H48O4 Salaspermic Acid 471.347435 0.2127 4.32 8.726 4 1 69.59 1 6 34 1
TCMC6849 C20H26O7 Triptriolide 378.1678533 -1.6537 2.89 -0.167 7 3 112.05 1 6 27 0
TCMC7084 C20H31NO2 Triptotin J 317.2354792 0.0505 3.33 3.182 3 2 52.82 1 3 23 0

Download Data

All data can be downloaded by:

   → Selecting data type in the below download table
   → Then click the download button.
Data Section
Select to Download
1. General Information of the Component  
2. TCM Prescriptions with the Component  
3. Putative Targets  
4. Activity & References for Filtering Putative Targets  
5. Ingredient Data & Chemical Structure Information (Properties, InChI, InChIkey, SMILES, etc.)