Component: Sesamum indicum 胡麻仁


Description of the Component

Component ID
TCMH914
Latin Name
Sesamum indicum
English Name
white seed of oriental sesame
Chinese Pinyin Name
Hu Ma Ren
中文名
胡麻仁
TCM Properties
TCM Meridians
Therapeutic Class English
Therapeutic Class Chinese
Functions
Toxicity
NA
Geo-authentic habitats (道地产区)
NA
Reference
CFDA
Barcode ID
GENG619-14, GBVT1400-13
Barcode Source
BOLDSYSTEMS

TCM Prescriptions with the Component

Prescription ID Prescription English Name Prescription Chinese Name
TCMFx7317 Qing Zao Jiu Fei Decoction 清燥救肺汤
TCMFx2888 Qing Zao Jiu Fei Decoction 清燥救肺汤

Targeted Human Proteins by the Ingredient of Component

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT1 EHMT2 Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Transferase Q96KQ7
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT11 HIF1A Hypoxia-inducible factor 1 alpha Transcription factor Q16665
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT132 BCHE Butyrylcholinesterase Hydrolase P06276
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT143 CA3 Carbonic anhydrase III Lyase P07451
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT151 PRKCA Protein kinase C alpha Kinase P17252
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT176 SOAT1 Acyl coenzyme A:cholesterol acyltransferase 1 Transferase P35610
TCMT18 GAA Lysosomal alpha-glucosidase Hydrolase P10253
TCMT186 MAOB Monoamine oxidase B Oxidoreductase P27338
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT213 SLC22A1 Solute carrier family 22 member 1 Transporter O15245
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT218 CYP2B6 Cytochrome P450 2B6 Oxidoreductase P20813
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT22 ALPI Intestinal alkaline phosphatase Hydrolase P09923
TCMT220 CYP2J2 Cytochrome P450 2J2 Oxidoreductase P51589
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT244 HRH1 Histamine H1 receptor GPCR P35367
TCMT273 NR1H4 Bile acid receptor FXR Nuclear receptor Q96RI1
TCMT276 SLCO2B1 Solute carrier organic anion transporter family member 2B1 Transporter O94956
TCMT277 SLCO1B3 Solute carrier organic anion transporter family member 1B3 Transporter Q9NPD5
TCMT278 SLCO1B1 Solute carrier organic anion transporter family member 1B1 Transporter Q9Y6L6
TCMT281 DPP4 Dipeptidyl peptidase IV Unclassified P27487
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT307 KCNH2 HERG Ion channel Q12809
TCMT31 CYP2C19 Cytochrome P450 2C19 Oxidoreductase P33261
TCMT311 SLC47A1 Multidrug and toxin extrusion protein 1 Transporter Q96FL8
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT341 NR1I2 Pregnane X receptor Nuclear receptor O75469
TCMT41 IDH1 Isocitrate dehydrogenase [NADP] cytoplasmic Oxidoreductase O75874
TCMT42 KMT2A Histone-lysine N-methyltransferase MLL Transferase Q03164
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT571 ADORA2B Adenosine A2b receptor GPCR P29275
TCMT588 DAO D-amino-acid oxidase Oxidoreductase P14920
TCMT594 PTAFR Platelet activating factor receptor GPCR P25105
TCMT596 SLC6A15 Sodium-dependent neutral amino acid transporter B(0)AT2 Transporter Q9H2J7
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT620 HSPA8 Heat shock cognate 71 kDa protein Unclassified P11142
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT632 PNP Purine nucleoside phosphorylase Transferase P00491
TCMT64 PPARD Peroxisome proliferator-activated receptor delta Nuclear receptor Q03181
TCMT67 PPARG Peroxisome proliferator-activated receptor gamma Nuclear receptor P37231
TCMT69 THRB Thyroid hormone receptor beta-1 Nuclear receptor P10828
TCMT704 ERBB2 Receptor protein-tyrosine kinase erbB-2 Kinase P04626
TCMT707 ADORA2A Adenosine A2a receptor GPCR P29274
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT80 MAPK1 MAP kinase ERK2 Kinase P28482
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712


Targeted Pathogenic Microbes by the Ingredient of Component

Target ID Target Name
TCMT1090 Human immunodeficiency virus type 1 integrase
TCMT1218 Staphylococcus aureus
TCMT1251 Candida albicans
TCMT1294 Human parainfluenza virus 3
TCMT1346 Helicobacter pylori
TCMT1438 Plasmodium falciparum
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1463 Mycobacterium tuberculosis
TCMT1465 Entamoeba histolytica

Ingredient Structrues

Ingredient ID: TCMC850
Formula: C8H10N4O2

Ingredient ID: TCMC801
Formula: C29H50O

Ingredient ID: TCMC673
Formula: C29H50O2

Ingredient ID: TCMC632
Formula: C10H13N5O4

Ingredient ID: TCMC614
Formula: C29H36O15

Ingredient ID: TCMC576
Formula: C21H18O13

Ingredient ID: TCMC448
Formula: C9H7NO

Ingredient ID: TCMC2457
Formula: C20H22O6

Ingredient ID: TCMC2232
Formula: C29H50O2

Ingredient ID: TCMC2223
Formula: C8H8O3

Ingredient ID: TCMC2222
Formula: C8H8O4

Ingredient ID: TCMC2219
Formula: C18H34O2

Ingredient ID: TCMC2209
Formula: C9H12N2O6

Ingredient ID: TCMC2107
Formula: C29H48O

Ingredient ID: TCMC2067
Formula: C7H6O3

Ingredient ID: TCMC2066
Formula: C20H18O6

Ingredient ID: TCMC2013
Formula: C16H12O7

Ingredient ID: TCMC19
Formula: C20H22O6

Ingredient ID: TCMC1899
Formula: C20H22O6

Ingredient ID: TCMC1788
Formula: C18H34O2

Ingredient ID: TCMC1741
Formula: C6H5NO2

Ingredient ID: TCMC1510
Formula: C22H23ClN2O2

Ingredient ID: TCMC1173
Formula: C10H10O4

Ingredient ID: TCMC1093
Formula: C27H46O2

Properties

Ingredient ID Formulae Name MW AlogP MlogP XlogP # HBA # HBD PSA # Rotatable Bond # Ring # Heacy Atom Lipinski RO5 Violation
TCMC19 C20H22O6 (-)-Pinoresinol 358.14 -2.0222 3 1.684 2 2 77.38 8 4 26 0
TCMC448 C9H7NO 3-Formylindole 145.05 -0.6128 2.23 2.53 2 1 32.86 1 2 11 0
TCMC576 C21H18O13 6-[2-(3,4-Dihydroxyphenyl)-5,7-Dihydroxy-4-Oxochromen-3-Yl]Oxy-3,4,5-Trihydroxyoxane-2-Carboxylic Acid 478.07 -4.7899 2.34 -0.197 8 8 223.67 12 4 34 1
TCMC614 C29H36O15 Acetoside 624.21 -4.2978 3 -0.202 11 9 245.29 21 4 44 3
TCMC632 C10H13N5O4 Adenosine 267.1 -2.2791 1.57 -1.809 9 4 139.54 6 3 19 0
TCMC673 C29H50O2 Alpha-Tochopherol 430.38 3.2935 4.43 10.938 0 1 29.46 21 2 31 2
TCMC801 C29H50O Beta-Sitosterol 414.39 1.3 4.54 11.595 1 1 20.23 13 4 30 1
TCMC850 C8H10N4O2 Caffeine 194.08 -0.4311 1.68 -0.625 6 0 58.44 3 2 14 0
TCMC1093 C27H46O2 E309 402.35 2.0095 4.21 10.714 0 1 29.46 19 2 29 2
TCMC1173 C10H10O4 Ferulic Acid 194.06 -0.3908 2.12 1.231 2 2 66.76 6 1 14 0
TCMC1510 C22H23ClN2O2 Loratadine 382.14 1.7488 3.33 4.263 4 0 42.43 5 4 27 0
TCMC1741 C6H5NO2 Niacin 123.03 -0.2398 1.79 0.637 3 1 50.19 2 1 9 0
TCMC1788 C18H34O2 Oleic Acid 282.26 -2.3427 3.22 8.192 2 1 37.3 17 0 20 2
TCMC1899 C20H22O6 Pinoresinol 358.14 -2.0222 3 1.684 2 2 77.38 8 4 26 0
TCMC2013 C16H12O7 Rhamnetin 316.06 -2.3927 2.45 1.9 2 4 116.45 7 3 23 0
TCMC2066 C20H18O6 Sesamin 354.11 -1.6034 3 2.576 2 0 55.38 2 6 26 0
TCMC2067 C7H6O3 Sesamol 138.03 -0.763 1.9 0.872 0 1 38.69 1 2 10 0
TCMC2107 C29H48O Stigmasterol 412.37 1.2566 4.54 11.071 1 1 20.23 12 4 30 1
TCMC2209 C9H12N2O6 Uridine 244.07 -2.5465 1.57 -1.782 8 4 122.82 6 2 17 0
TCMC2219 C18H34O2 Vaccenic Acid 282.26 -2.3427 3.22 8.192 2 1 37.3 17 0 20 2
TCMC2222 C8H8O4 Vanillic Acid 168.04 -0.7519 1.9 0.626 2 2 66.76 5 1 12 0
TCMC2223 C8H8O3 Vanillin 152.05 -0.7045 2.01 1.04 1 1 46.53 4 1 11 0
TCMC2232 C29H50O2 Vitamin E 430.38 3.2935 4.43 10.938 0 1 29.46 21 2 31 2
TCMC2457 C20H22O6 (+/-)-Pinoresinol 358.14 -2.0222 3 1.684 2 2 77.38 8 4 26 0

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1. General Information of the Component  
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3. Putative Targets  
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