Component: Trichosanthes kirilowii maxim 瓜蒌子


Description of the Component

Component ID
TCMH710
Latin Name
Trichosanthes kirilowii maxim
English Name
mongolian snakegourd seed
Chinese Pinyin Name
Gua Lou Zi
中文名
瓜蒌子
TCM Properties
TCM Meridians
Therapeutic Class English
Therapeutic Class Chinese
Functions
Toxicity
NA
Geo-authentic habitats (道地产区)
NA
Reference
Chinese Pharmacopoeia (2015)
Barcode ID
ITSAO4359-14
Barcode Source
BOLDSYSTEMS

TCM Prescriptions with the Component

Prescription ID Prescription English Name Prescription Chinese Name
TCMFx3175 Bai Ke Jing Syrup 百咳静糖浆
TCMFx499 Bai Ke Jing Syrup 百咳静糖浆
TCMFx3692 Da Fei Cao 达肺草
TCMF3031 Er Mu Ning Sou Granules 二母宁嗽颗粒
TCMF3039 Er Mu Ning Sou Pills 二母宁嗽丸
TCMF186 Er Mu Ning Sou Pills 二母宁嗽丸
TCMFx3670 Fu Fang Li Ointment 复方梨膏
TCMFx3995 Ge Jie Ding Chuan Pills 蛤蚧定喘丸
TCMF4004 Ge Jie Yang Fei Pills 蛤蚧养肺丸
TCMFx1040 Ge Jie Ding Chuan Capsule 蛤蚧定喘胶囊
TCMF4588 Ji Su Pills 鸡苏丸
TCMFx6987 Jian Fei Pills 健肺丸
TCMFx6889 Jing Dou Nian Ci An Mi Lian Chuan Bei Pi Pa Ointment 京都念慈菴蜜炼川贝枇杷膏
TCMF4271 Ke Chuan Shun Pills 咳喘顺丸
TCMF5157 Qing Fei Hua Tan Pills 清肺化痰丸
TCMF83 Qing Fei Hua Tan Pills 清肺化痰丸
TCMF5333 Qing Jin Ning Fei Pills 清金宁肺丸
TCMFx5465 Qing Qi Hua Tan Pills 清气化痰丸
TCMF5775 Run Fei Zhi Sou Pills 润肺止嗽丸
TCMF960 Run Fei Zhi Sou Pills 润肺止嗽丸
TCMF6011 Sou Feng Li Fei Pills 搜风理肺丸
TCMF6534 Xiao Er Zhi Sou Jin Dan 小儿止嗽金丹
TCMF6541 Xiao Er Zhi Sou Jin Pills 小儿止嗽金丸
TCMF6558 Xiao Er Zhi Sou Pills 小儿止嗽丸
TCMFx235 Xiao Er Zhi Sou Syrup 小儿止嗽糖浆
TCMFx6549 Xiao Er Zhi Sou Syrup 小儿止嗽糖浆
TCMF6667 Xie Bai Pills 泻白丸
TCMFx6661 Xie Bai Syrup 泻白糖浆
TCMF323 Zhi Sou Hua Tan Pills 止嗽化痰丸
TCMF6581 Zhi Sou Hua Tan Pills 止嗽化痰丸
TCMF6604 Zhi Sou Qing Guo Tablets 止嗽青果片
TCMF6615 Zhi Sou Sao Tan Pills 止嗽扫痰丸

Targeted Human Proteins by the Ingredient of Component

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT1 EHMT2 Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Transferase Q96KQ7
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT108 GRIA1 Glutamate receptor ionotropic, AMPA 1 Ion channel P42261
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT125 GBA Beta-glucocerebrosidase Hydrolase P04062
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT176 SOAT1 Acyl coenzyme A:cholesterol acyltransferase 1 Transferase P35610
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT213 SLC22A1 Solute carrier family 22 member 1 Transporter O15245
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT248 CXCL8 Interleukin-8 Unclassified P10145
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT307 KCNH2 HERG Ion channel Q12809
TCMT31 CYP2C19 Cytochrome P450 2C19 Oxidoreductase P33261
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT340 GLRA1 Glycine receptor subunit alpha-1 Ion channel P23415
TCMT341 NR1I2 Pregnane X receptor Nuclear receptor O75469
TCMT41 IDH1 Isocitrate dehydrogenase [NADP] cytoplasmic Oxidoreductase O75874
TCMT42 KMT2A Histone-lysine N-methyltransferase MLL Transferase Q03164
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT559 ADRB2 Beta-2 adrenergic receptor GPCR P07550
TCMT6 NFKB1 Nuclear factor NF-kappa-B p105 subunit Transcription factor P19838
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT64 PPARD Peroxisome proliferator-activated receptor delta Nuclear receptor Q03181
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT661 FOLH1 Glutamate carboxypeptidase II Hydrolase Q04609
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT67 PPARG Peroxisome proliferator-activated receptor gamma Nuclear receptor P37231
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372


Targeted Pathogenic Microbes by the Ingredient of Component

Target ID Target Name
TCMT1218 Staphylococcus aureus
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1232 Pseudomonas aeruginosa
TCMT1246 Escherichia coli
TCMT1251 Candida albicans
TCMT1354 Streptococcus mutans UA159
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1442 Leishmania donovani
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans

Ingredient Structrues

Ingredient ID: TCMC999
Formula: C10H20O2

Ingredient ID: TCMC985
Formula: C3H7NO2

Ingredient ID: TCMC734
Formula: C4H7NO4

Ingredient ID: TCMC721
Formula: C6H14N4O2

Ingredient ID: TCMC553
Formula: C6H6O3

Ingredient ID: TCMC510
Formula: C6H5NO3

Ingredient ID: TCMC2696
Formula: C28H56O2

Ingredient ID: TCMC2594
Formula: C6H13NO2

Ingredient ID: TCMC2408
Formula: C5H11NO2

Ingredient ID: TCMC2223
Formula: C8H8O3

Ingredient ID: TCMC2222
Formula: C8H8O4

Ingredient ID: TCMC2200
Formula: C9H11NO3

Ingredient ID: TCMC2188
Formula: C17H14O7

Ingredient ID: TCMC2105
Formula: C18H36O2

Ingredient ID: TCMC2062
Formula: C3H7NO3

Ingredient ID: TCMC1832
Formula: C16H30O2

Ingredient ID: TCMC1830
Formula: C16H32O2

Ingredient ID: TCMC1788
Formula: C18H34O2

Ingredient ID: TCMC164
Formula: C3H7NO2S

Ingredient ID: TCMC1611
Formula: C14H28O2

Ingredient ID: TCMC1535
Formula: C6H14O6

Ingredient ID: TCMC1513
Formula: C5H9NO2

Ingredient ID: TCMC1512
Formula: C9H11NO2

Ingredient ID: TCMC1496
Formula: C18H30O2

Ingredient ID: TCMC1480
Formula: C5H9NO4

Ingredient ID: TCMC1331
Formula: C6H9N3O2

Ingredient ID: TCMC1271
Formula: C2H5NO2

Ingredient ID: TCMC1259
Formula: C24H34N4O5S

Ingredient ID: TCMC1194
Formula: C4H4O4

Ingredient ID: TCMC1081
Formula: C12H24O2

Ingredient ID: TCMC1064
Formula: C16H12O6

Properties

Ingredient ID Formulae Name MW AlogP MlogP XlogP # HBA # HBD PSA # Rotatable Bond # Ring # Heacy Atom Lipinski RO5 Violation
TCMC164 C3H7NO2S (R)-Cysteine 121.02 -0.6242 1.35 -2.575 3 2 102.12 5 0 7 0
TCMC510 C6H5NO3 4-Oxo-1H-Pyridine-3-Carboxylic Acid 139.03 -1.3327 1.68 0.824 4 2 66.4 2 1 10 0
TCMC553 C6H6O3 5-Hydroxymethyl-Furfural 126.03 -0.7952 1.79 0.422 2 1 50.44 3 1 9 0
TCMC721 C6H14N4O2 Arginine 174.11 -2.1807 1.46 -2.924 6 5 125.22 9 0 12 0
TCMC734 C4H7NO4 Aspartic Acid 133.04 -1.3518 1.35 -3.707 5 3 100.62 6 0 9 0
TCMC985 C3H7NO2 D-Alanine 89.05 -1.0955 1.46 -2.824 3 2 63.32 4 0 6 0
TCMC999 C10H20O2 Decanoic Acid 172.15 -2.1697 2.34 4.156 2 1 37.3 10 0 12 0
TCMC1064 C16H12O6 Diosmetin 300.06 -1.9363 2.56 1.123 1 3 96.22 6 3 22 0
TCMC1081 C12H24O2 Dodecanoate 200.18 -2.7457 2.56 5.294 2 1 37.3 12 0 14 1
TCMC1194 C4H4O4 Fumaric Acid 116.01 -0.2252 1.46 -0.416 4 2 74.6 4 0 8 0
TCMC1259 C24H34N4O5S Glimepiride 490.22 0.2885 3 4.487 9 3 140.04 14 3 34 0
TCMC1271 C2H5NO2 Glycine 75.03 -1.1915 1.35 -3.35 3 2 63.32 3 0 5 0
TCMC1331 C6H9N3O2 Histidine 155.07 -1.3116 1.57 -3.134 5 3 92 5 1 11 0
TCMC1480 C5H9NO4 L-Glutamate 147.05 -1.6398 1.46 -3.349 5 3 100.62 7 0 10 0
TCMC1496 C18H30O2 Linolenic Acid 278.22 -0.0979 3.22 7.538 2 1 37.3 15 0 20 2
TCMC1512 C9H11NO2 L-Phenylalanine 165.08 -1.0844 2.12 0.441 3 2 63.32 5 1 12 0
TCMC1513 C5H9NO2 L-Proline 115.06 -1.3817 1.68 -0.185 3 2 49.33 2 1 8 0
TCMC1535 C6H14O6 Mannitol 182.08 -2.9402 1.46 -3.896 6 6 121.38 11 0 12 1
TCMC1611 C14H28O2 Myristic Acid 228.21 -3.3217 2.78 6.432 2 1 37.3 14 0 16 2
TCMC1788 C18H34O2 Oleic Acid 282.26 -2.3427 3.22 8.192 2 1 37.3 17 0 20 2
TCMC1830 C16H32O2 Palmitic Acid 256.24 -3.8977 3 7.57 2 1 37.3 16 0 18 2
TCMC1832 C16H30O2 Palmitoleic Acid 254.22 -1.7667 3 7.054 2 1 37.3 15 0 18 2
TCMC2062 C3H7NO3 Serine 105.04 -1.5955 1.35 -3.956 4 3 83.55 5 0 7 0
TCMC2105 C18H36O2 Stearic Acid 284.27 -4.4737 3.22 8.708 2 1 37.3 18 0 20 2
TCMC2188 C17H14O7 Tricin 330.07 -1.9881 2.56 0.679 1 3 105.45 8 3 24 0
TCMC2200 C9H11NO3 Tyrosine 181.07 -1.5447 2.01 -1.577 3 3 83.55 6 1 13 0
TCMC2222 C8H8O4 Vanillic Acid 168.04 -0.7519 1.9 0.626 2 2 66.76 5 1 12 0
TCMC2223 C8H8O3 Vanillin 152.05 -0.7045 2.01 1.04 1 1 46.53 4 1 11 0
TCMC2408 C5H11NO2 Valine 117.08 -0.5739 1.68 -2.169 3 2 63.32 6 0 8 0
TCMC2594 C6H13NO2 Leucine 131.09 -0.3183 1.79 -1.389 3 2 63.32 7 0 9 0
TCMC2696 C28H56O2 N-Octacosanoic Acid 424.43 -7.3537 4.32 14.398 2 1 37.3 28 0 30 2

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1. General Information of the Component  
2. TCM Prescriptions with the Component  
3. Putative Targets  
4. Activity & References for Filtering Putative Targets  
5. Ingredient Data & Chemical Structure Information (Properties, InChI, InChIkey, SMILES, etc.)