TCM-ID Prescription

Prescription Description

Prescription ID	TCMFx3670
Pinyin Name	Fu Fang Li Gao
Chinese Name	复方梨膏
English Name	Fu Fang Li Ointment
Function Description	咳嗽, 哮病, 喘病
Indications	Wheezing disorder, Dyspnea
Disease ICD-11 Category	SA81 [Wheezing disorder (TM1), 哮病 (TM1) ]; MD11.5 [Dyspnoea, 呼吸困难 ];
Human Tissues Associated with Indication	Lung
Reference	CFDA
Reference Book/link	http://samr.cfda.gov.cn/WS01/CL0001/

Prescription Components

Component ID	Latin Name	Chinese Name	Component Quantity	Barcode
TCMH1266	‎Pyrus spp	梨	TCMH1266
TCMH1542	Radix adenophorae	南沙参	TCMH1542
TCMH2728	Aster tataricus	紫菀	TCMH2728	ITSAI2445-14
TCMH1398	Ephedra sinica	麻黄	TCMH1398	ITSAM882-14
TCMH1223	Tussilago farfara	款冬花	TCMH1223	ITSAH4326-14
TCMH2725	Fructus perillae	紫苏子	TCMH2725
TCMH1080	Platycodon grandiflorum	桔梗	TCMH1080	ITSAJ4293-14
TCMH2722	Perilla frutescens var. arguta	紫苏叶	TCMH2722	ITSAF2620-14
TCMH1656	Angelica decursiva	前胡	TCMH1656	ITSAN4164-14
TCMH1797	Morus alba	桑叶	TCMH1797	ITSAL1073-14
TCMH2618	Citrus aurantium	枳壳	TCMH2618	ITSAA1279-14
TCMH628	Glycyrrhiza uralensis	甘草	TCMH628	ITSAM892-14
TCMH606	Wolfiporia cocos	茯苓	TCMH606	GBPOL314-13
TCMH90	Imperata cylindrica	白茅根	TCMH90	ITSAP888-14
TCMH46	Stemona tuberosa	百部	TCMH46	GBVC4204-11, GBVC4202-11
TCMH72	Bletilla striata	白芨	TCMH72	ITSAJ4380-14
TCMH552	Rhizoma pinelliae preparata	法半夏	TCMH552
TCMH1090	Brassica juncea	芥子	TCMH1090	ITSAJ4546-14
TCMH2596	Fritillaria verticillata	浙贝母	TCMH2596
TCMH825	Nelumbo nucifera	荷叶	TCMH825	ITSAI3109-14
TCMH2551	Polygonatum odoratum	玉竹	TCMH2551	ITSAM921-14
TCMH710	Trichosanthes kirilowii maxim	瓜蒌子	TCMH710	ITSAO4359-14
TCMH243	Pericarpium citri reticulatae	陈皮	TCMH243
TCMH2084	Asparagus cochinchinensis	天冬	TCMH2084	ITSAJ4142-14
TCMH104	Paeonia lactiflora	白芍	TCMH104	ITSAH2416-14
TCMH1600	nodus nelumbinis rhizomatis	藕节	TCMH1600
TCMH1219	Semen armeniacae amarum	苦杏仁	TCMH1219
TCMH2736	Petiolus trachycarpi	棕榈	TCMH2736
TCMH541	Colla corii asini	阿胶	TCMH541
TCMH1617	Eriobotrya japonica thunb	枇杷叶	TCMH1617	ITSAN1970-14
TCMH2641	Gardenia jasminoides	栀子	TCMH2641	ITSAJ4473-14

Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID	Gene Symbol	Target Name	Target Class	Uniprot ID
TCMT100	TTR	Transthyretin	Unclassified	P02766
TCMT101	PTPN1	Protein-tyrosine phosphatase 1B	Hydrolase	P18031
TCMT107	GRIK2	Glutamate receptor ionotropic kainate 2	Ion channel	Q13002
TCMT109	GRIA2	Glutamate receptor ionotropic, AMPA 2	Ion channel	P42262
TCMT11	HIF1A	Hypoxia-inducible factor 1 alpha	Transcription factor	Q16665
TCMT110	GRIA4	Glutamate receptor ionotropic, AMPA 4	Ion channel	P48058
TCMT111	GRIK5	Glutamate receptor ionotropic kainate 5	Ion channel	Q16478
TCMT112	ADORA3	Adenosine A3 receptor	GPCR	P0DMS8
TCMT114	CNR2	Cannabinoid CB2 receptor	GPCR	P34972
TCMT115	CNR1	Cannabinoid CB1 receptor	GPCR	P21554
TCMT118	MGAM	Maltase-glucoamylase	Hydrolase	O43451
TCMT124	FUCA1	Alpha-L-fucosidase I	Hydrolase	P04066
TCMT125	GBA	Beta-glucocerebrosidase	Hydrolase	P04062
TCMT126	TERT	Telomerase reverse transcriptase	Transferase	O14746
TCMT127	PARP1	Poly [ADP-ribose] polymerase-1	Transferase	P09874
TCMT128	TNKS2	Tankyrase-2	Transferase	Q9H2K2
TCMT129	TNKS	Tankyrase-1	Transferase	O95271
TCMT13	APEX1	DNA-(apurinic or apyrimidinic site) lyase	Lyase	P27695
TCMT130	ALOX5	Arachidonate 5-lipoxygenase	Oxidoreductase	P09917
TCMT131	ACHE	Acetylcholinesterase	Hydrolase	P22303
TCMT133	CA1	Carbonic anhydrase I	Lyase	P00915
TCMT134	CA2	Carbonic anhydrase II	Lyase	P00918
TCMT135	CA14	Carbonic anhydrase XIV	Lyase	Q9ULX7
TCMT136	CA12	Carbonic anhydrase XII	Lyase	O43570
TCMT137	CA9	Carbonic anhydrase IX	Lyase	Q16790
TCMT138	CA7	Carbonic anhydrase VII	Lyase	P43166
TCMT142	CA4	Carbonic anhydrase IV	Lyase	P22748
TCMT156	CYP19A1	Cytochrome P450 19A1	Oxidoreductase	P11511
TCMT159	TYR	Tyrosinase	Oxidoreductase	P14679
TCMT162	UGT1A1	UDP-glucuronosyltransferase 1-1	Transferase	P22309
TCMT164	PTGS1	Cyclooxygenase-1	Oxidoreductase	P23219
TCMT17	POLB	DNA polymerase beta	Transferase	P06746
TCMT171	PTPN6	Protein-tyrosine phosphatase 1C	Hydrolase	P29350
TCMT174	HSD11B1	11-beta-hydroxysteroid dehydrogenase 1	Oxidoreductase	P28845
TCMT18	GAA	Lysosomal alpha-glucosidase	Hydrolase	P10253
TCMT189	DUSP3	Dual specificity protein phosphatase 3	Hydrolase	P51452
TCMT190	PTPN2	T-cell protein-tyrosine phosphatase	Hydrolase	P17706
TCMT197	PDE4D	Phosphodiesterase 4D	Hydrolase	Q08499
TCMT2	MAPT	Microtubule-associated protein tau	Unclassified	P10636
TCMT206	CYP2A6	Cytochrome P450 2A6	Oxidoreductase	P11509
TCMT207	BACE1	Beta-secretase 1	Protease	P56817
TCMT209	HSD11B2	11-beta-hydroxysteroid dehydrogenase 2	Oxidoreductase	P80365
TCMT210	CES2	Carboxylesterase 2	Hydrolase	O00748
TCMT212	SRC	Tyrosine-protein kinase SRC	Kinase	P12931
TCMT215	CYP1A1	Cytochrome P450 1A1	Oxidoreductase	P04798
TCMT217	CYP2C8	Cytochrome P450 2C8	Oxidoreductase	P10632
TCMT219	CYP1A2	Cytochrome P450 1A2	Oxidoreductase	P05177
TCMT22	ALPI	Intestinal alkaline phosphatase	Hydrolase	P09923
TCMT221	ABCB11	Bile salt export pump	Transporter	O95342
TCMT223	AKR1B1	Aldose reductase	Oxidoreductase	P15121
TCMT226	PDPK1	3-phosphoinositide dependent protein kinase-1	Kinase	O15530
TCMT23	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	Hydrolase	P05186
TCMT231	GBA2	Beta-glucosidase	Hydrolase	Q9HCG7
TCMT232	ABCB1	P-glycoprotein 1	Transporter	P08183
TCMT233	PTPN11	Protein-tyrosine phosphatase 2C	Hydrolase	Q06124
TCMT236	ESR2	Estrogen receptor beta	Nuclear receptor	Q92731
TCMT239	PIM1	Serine/threonine-protein kinase PIM1	Kinase	P11309
TCMT249	CDK6	Cyclin-dependent kinase 6	Kinase	Q00534
TCMT254	CBR1	Carbonyl reductase [NADPH] 1	Oxidoreductase	P16152
TCMT257	CYP1B1	Cytochrome P450 1B1	Oxidoreductase	Q16678
TCMT260	FLT3	Tyrosine-protein kinase receptor FLT3	Kinase	P36888
TCMT261	DAPK1	Death-associated protein kinase 1	Kinase	P53355
TCMT268	CYP2A13	Cytochrome P450 2A13	Oxidoreductase	Q16696
TCMT280	AKR1B10	Aldo-keto reductase family 1 member B10	Oxidoreductase	O60218
TCMT289	TBXAS1	Thromboxane-A synthase	Isomerase	P24557
TCMT293	CHRM2	Muscarinic acetylcholine receptor M2	GPCR	P08172
TCMT295	MMP1	Matrix metalloproteinase-1	Hydrolase	P03956
TCMT296	ADORA1	Adenosine A1 receptor	GPCR	P30542
TCMT297	FABP4	Fatty acid binding protein adipocyte	Unclassified	P15090
TCMT298	FABP3	Fatty acid binding protein muscle	Hydrolase	P05413
TCMT30	PTGS2	Cyclooxygenase-2	Oxidoreductase	P35354
TCMT302	HMGCR	HMG-CoA reductase	Oxidoreductase	P04035
TCMT304	MMP14	Matrix metalloproteinase 14	Hydrolase	P50281
TCMT306	MMP2	Matrix metalloproteinase-2	Hydrolase	P08253
TCMT321	MMP9	Matrix metalloproteinase 9	Hydrolase	P14780
TCMT322	MMP13	Matrix metalloproteinase 13	Hydrolase	P45452
TCMT329	NQO2	Quinone reductase 2	Oxidoreductase	P16083
TCMT337	XPO1	Exportin-1	Unclassified	O14980
TCMT344	AOX1	Aldehyde oxidase	Oxidoreductase	Q06278
TCMT347	MAN1B1	Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase	Hydrolase	Q9UKM7
TCMT354	AURKA	Serine/threonine-protein kinase Aurora-A	Kinase	O14965
TCMT36	HTR1A	Serotonin 1a (5-HT1a) receptor	GPCR	P08908
TCMT369	IGF1R	Insulin-like growth factor I receptor	Kinase	P08069
TCMT370	KDR	Vascular endothelial growth factor receptor 2	Kinase	P35968
TCMT374	AURKB	Serine/threonine-protein kinase Aurora-B	Kinase	Q96GD4
TCMT377	INSR	Insulin receptor	Kinase	P06213
TCMT38	DRD2	Dopamine D2 receptor	GPCR	P14416
TCMT388	AXL	Tyrosine-protein kinase receptor UFO	Kinase	P30530
TCMT401	MET	Hepatocyte growth factor receptor	Kinase	P08581
TCMT418	EPHB4	Ephrin type-B receptor 4	Kinase	P54760
TCMT422	CAMK2B	CaM kinase II beta	Kinase	Q13554
TCMT423	EGFR	Epidermal growth factor receptor erbB1	Kinase	P00533
TCMT436	NUAK1	NUAK family SNF1-like kinase 1	Kinase	O60285
TCMT44	GLO1	Glyoxalase I	Lyase	Q04760
TCMT445	NEK2	Serine/threonine-protein kinase NEK2	Kinase	P51955
TCMT45	APP	Beta amyloid A4 protein	Unclassified	P05067
TCMT457	FLT4	Vascular endothelial growth factor receptor 3	Kinase	P35916
TCMT46	F3	Coagulation factor III	Unclassified	P13726
TCMT462	NEK6	Serine/threonine-protein kinase NEK6	Kinase	Q9HC98
TCMT47	BCL2	Apoptosis regulator Bcl-2	Ion channel	P10415
TCMT479	AKT1	Serine/threonine-protein kinase AKT	Kinase	P31749
TCMT484	PLK1	Serine/threonine-protein kinase PLK1	Kinase	P53350
TCMT502	TEK	Tyrosine-protein kinase TIE-2	Kinase	Q02763
TCMT506	PTK2B	Protein tyrosine kinase 2 beta	Kinase	Q14289
TCMT510	KIT	Stem cell growth factor receptor	Kinase	P10721
TCMT536	PDGFRB	Platelet-derived growth factor receptor beta	Kinase	P09619
TCMT558	TOP2A	DNA topoisomerase II alpha	Isomerase	P11388
TCMT560	F10	Coagulation factor X	Unclassified	P00742
TCMT561	NT5E	5'-nucleotidase	Hydrolase	P21589
TCMT563	CDC25B	Dual specificity phosphatase Cdc25B	Hydrolase	P30305
TCMT565	EP300	Histone acetyltransferase p300	Transferase	Q09472
TCMT567	DNMT1	DNA (cytosine-5)-methyltransferase 1	Transferase	P26358
TCMT588	DAO	D-amino-acid oxidase	Oxidoreductase	P14920
TCMT591	ESRRA	Estrogen-related receptor alpha	Nuclear receptor	P11474
TCMT592	XDH	Xanthine dehydrogenase	Oxidoreductase	P47989
TCMT597	SLC28A3	Solute carrier family 28 member 3	Transporter	Q9HAS3
TCMT599	UBE2N	Ubiquitin-conjugating enzyme E2 N	Transferase	P61088
TCMT614	EGLN1	Egl nine homolog 1	Oxidoreductase	Q9GZT9
TCMT626	BRAF	Serine/threonine-protein kinase B-raf	Kinase	P15056
TCMT63	PPARA	Peroxisome proliferator-activated receptor alpha	Nuclear receptor	Q07869
TCMT636	POLA1	DNA polymerase alpha subunit	Transferase	P09884
TCMT65	HSD17B1	Estradiol 17-beta-dehydrogenase 1	Oxidoreductase	P14061
TCMT653	GRM1	Metabotropic glutamate receptor 1	GPCR	Q13255
TCMT654	GRM5	Metabotropic glutamate receptor 5	GPCR	P41594
TCMT655	GRM2	Metabotropic glutamate receptor 2	GPCR	Q14416
TCMT656	GRM3	Metabotropic glutamate receptor 3	GPCR	Q14832
TCMT657	GRM4	Metabotropic glutamate receptor 4	GPCR	Q14833
TCMT66	HSD17B2	Estradiol 17-beta-dehydrogenase 2	Oxidoreductase	P37059
TCMT660	GRM8	Metabotropic glutamate receptor 8	GPCR	O00222
TCMT664	SLC1A1	Excitatory amino acid transporter 3	Transporter	P43005
TCMT680	KAT2B	Histone acetyltransferase PCAF	Transferase	Q92831
TCMT683	MIF	Macrophage migration inhibitory factor	Isomerase	P14174
TCMT690	HDAC3	Histone deacetylase 3	Hydrolase	O15379
TCMT698	PDE4B	Phosphodiesterase 4B	Hydrolase	Q07343
TCMT709	SLC28A2	Sodium/nucleoside cotransporter 2	Transporter	O43868
TCMT710	SLC28A1	Sodium/nucleoside cotransporter 1	Transporter	O00337
TCMT721	HSPA1A	Heat shock 70 kDa protein 1	Unclassified	P0DMV8
TCMT729	PIK3CA	PI3-kinase p110-alpha subunit	Transferase	P42336
TCMT730	PIK3CB	PI3-kinase p110-beta subunit	Transferase	P42338
TCMT734	MMP12	Matrix metalloproteinase 12	Hydrolase	P39900
TCMT737	APOBEC3G	DNA dC->dU-editing enzyme APOBEC-3G	Unclassified	Q9HC16
TCMT739	GPR35	G-protein coupled receptor 35	GPCR	Q9HC97
TCMT740	PIK3CG	PI3-kinase p110-gamma subunit	Transferase	P48736
TCMT751	DYRK1A	Dual-specificity tyrosine-phosphorylation regulated kinase 1A	Kinase	Q13627
TCMT752	CSNK2A1	Casein kinase II alpha	Kinase	P68400
TCMT753	SMAD3	Mothers against decapentaplegic homolog 3	Unclassified	P84022
TCMT755	PLK4	Serine/threonine-protein kinase PLK4	Kinase	O00444
TCMT756	MAP3K8	Mitogen-activated protein kinase kinase kinase 8	Kinase	P41279
TCMT759	SAE1	SUMO-activating enzyme subunit 1	Unclassified	Q9UBE0
TCMT781	CYP2E1	Cytochrome P450 2E1	Oxidoreductase	P05181
TCMT784	AVPR2	Vasopressin V2 receptor	GPCR	P30518
TCMT785	CXCR1	Interleukin-8 receptor A	GPCR	P25024
TCMT786	CCR4	C-C chemokine receptor type 4	GPCR	P51679
TCMT791	PKN1	Protein kinase N1	Kinase	Q16512
TCMT793	PYGL	Liver glycogen phosphorylase	Transferase	P06737
TCMT8	KDM4E	Lysine-specific demethylase 4D-like	Oxidoreductase	B2RXH2
TCMT807	SLC22A12	Solute carrier family 22 member 12	Transporter	Q96S37
TCMT808	FABP5	Fatty acid binding protein epidermal	Unclassified	Q01469
TCMT809	FABP2	Fatty acid binding protein intestinal	Unclassified	P12104
TCMT810	TLR2	Toll-like receptor 2	Unclassified	O60603
TCMT82	ESR1	Estrogen receptor alpha	Nuclear receptor	P03372
TCMT822	FUT7	Alpha-(1,3)-fucosyltransferase 7	Transferase	Q11130
TCMT83	CD38	Lymphocyte differentiation antigen CD38	Unclassified	P28907
TCMT87	CYP2C9	Cytochrome P450 2C9	Oxidoreductase	P11712
TCMT910	ESRRB	Estrogen-related receptor beta	Nuclear receptor	O95718
TCMT953	PNMT	Phenylethanolamine N-methyltransferase	Transferase	P11086

Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID	Target Name
TCMT1170	Enterobacter cloacae
TCMT1172	Staphylococcus aureus subsp. aureus RN4220
TCMT1175	Human immunodeficiency virus
TCMT1176	Streptococcus pneumoniae
TCMT1178	Actinomyces viscosus
TCMT1179	Escherichia coli ATCC 8739
TCMT1181	Mycobacterium tuberculosis H37Ra
TCMT1182	Streptococcus sanguinis
TCMT1186	Plasmodium yoelii yoelii
TCMT1187	Enterococcus faecalis ATCC 29212
TCMT1189	Pseudomonas fluorescens
TCMT1190	Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1191	Bacillus megaterium
TCMT1207	Legionella pneumophila
TCMT1208	Escherichia coli K12
TCMT1209	Staphylococcus haemolyticus
TCMT1210	Streptococcus sobrinus
TCMT1211	Fusobacterium nucleatum
TCMT1212	Verticillium dahliae
TCMT1213	Neisseria gonorrhoeae
TCMT1214	Enterococcus faecium
TCMT1215	Pseudomonas aeruginosa PAO1
TCMT1217	Bacillus anthracis
TCMT1218	Staphylococcus aureus
TCMT1221	Human herpesvirus 4
TCMT1222	Plasmodium falciparum D6
TCMT1223	Staphylococcus epidermidis
TCMT1224	Proteus mirabilis
TCMT1226	Klebsiella pneumoniae
TCMT1227	Streptococcus
TCMT1229	Enterococcus faecalis
TCMT1231	Human herpesvirus 1 strain KOS
TCMT1232	Pseudomonas aeruginosa
TCMT1234	Bacillus coagulans
TCMT1235	Clostridium sporogenes
TCMT1236	Mycobacterium bovis
TCMT1237	Mycobacterium kansasii
TCMT1238	Mycobacterium xenopi
TCMT1239	Mycobacterium marinum
TCMT1243	Aspergillus flavus
TCMT1246	Escherichia coli
TCMT1248	Hepatitis C virus
TCMT1249	Dengue virus 2
TCMT1251	Candida albicans
TCMT1253	Penicillium chrysogenum
TCMT1255	Human immunodeficiency virus 1
TCMT1260	Streptococcus agalactiae
TCMT1282	Colletotrichum orbiculare
TCMT1284	Penicillium expansum
TCMT1286	Bacillus cereus
TCMT1289	Shigella dysenteriae
TCMT1294	Human parainfluenza virus 3
TCMT1296	Influenza A virus H3N2
TCMT1310	Enterococcus hirae
TCMT1318	Human T-lymphotropic virus 1
TCMT1319	Corynebacterium xerosis
TCMT1321	Staphylococcus hominis
TCMT1322	Streptococcus mitis
TCMT1323	Corynebacterium pseudodiphtheriticum
TCMT1324	Corynebacterium diphtheriae
TCMT1343	Staphylococcus simulans
TCMT1344	Staphylococcus sciuri
TCMT1346	Helicobacter pylori
TCMT1349	Helicobacter pylori SS1
TCMT1354	Streptococcus mutans UA159
TCMT1355	Rhodococcus equi
TCMT1361	Neisseria meningitidis
TCMT1370	Prevotella melaninogenica
TCMT1382	Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393	Vibrio sp.
TCMT1408	Colletotrichum gloeosporioides
TCMT1410	Listeria monocytogenes
TCMT1412	Salmonella typhimurium
TCMT1438	Plasmodium falciparum
TCMT1439	Mycobacterium smegmatis
TCMT1442	Leishmania donovani
TCMT1443	Leishmania amazonensis
TCMT1444	Fusarium oxysporum
TCMT1447	Respiratory syncytial virus
TCMT1448	Enterobacter aerogenes
TCMT1449	Influenza A virus
TCMT1450	Plasmodium falciparum 3D7
TCMT1454	Bacillus subtilis
TCMT1455	Mycobacterium tuberculosis H37Rv
TCMT1457	Leishmania major
TCMT1458	Filobasidiella neoformans
TCMT1462	Streptococcus mutans
TCMT1463	Mycobacterium tuberculosis
TCMT1464	Hepatitis B virus
TCMT1465	Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term	GO Name	Enriched Genes	Log10 Adjusted P-value

KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID	Enriched Genes	Log10 Adjusted P-value

Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset

Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples

Data Section	Select to Download
1. General Information of Prescription
2. Putative Targets
3. Activity & References for Filtering Putative Targets
4. GO & Pathway

TCM Prescription: Fu Fang Li Ointment