Component: Bubalus bubalis 牛角尖粉


Description of the Component

Component ID
TCMH1576
Latin Name
Bubalus bubalis
English Name
Buffalo horn
Chinese Pinyin Name
Niu Jiao Jian Fen
中文名
牛角尖粉
TCM Properties
TCM Meridians
Therapeutic Class English
Therapeutic Class Chinese
Functions
Toxicity
NA
Geo-authentic habitats (道地产区)
NA
Reference
Chinese Pharmacopoeia (2015)
Barcode ID
GBMA0080-06
Barcode Source
BOLDSYSTEMS

TCM Prescriptions with the Component

Prescription ID Prescription English Name Prescription Chinese Name
TCMFx934 Yi Xin Pills 益心丸

Targeted Human Proteins by the Ingredient of Component

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT1 EHMT2 Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Transferase Q96KQ7
TCMT105 SLC15A2 Solute carrier family 15 member 2 Transporter Q16348
TCMT11 HIF1A Hypoxia-inducible factor 1 alpha Transcription factor Q16665
TCMT125 GBA Beta-glucocerebrosidase Hydrolase P04062
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT175 GPBAR1 G-protein coupled bile acid receptor 1 GPCR Q8TDU6
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT213 SLC22A1 Solute carrier family 22 member 1 Transporter O15245
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT243 ADRA2C Alpha-2c adrenergic receptor GPCR P18825
TCMT247 ADRA2A Alpha-2a adrenergic receptor GPCR P08913
TCMT248 CXCL8 Interleukin-8 Unclassified P10145
TCMT267 GABRR1 GABA receptor rho-1 subunit Ion channel P24046
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT273 NR1H4 Bile acid receptor FXR Nuclear receptor Q96RI1
TCMT276 SLCO2B1 Solute carrier organic anion transporter family member 2B1 Transporter O94956
TCMT277 SLCO1B3 Solute carrier organic anion transporter family member 1B3 Transporter Q9NPD5
TCMT278 SLCO1B1 Solute carrier organic anion transporter family member 1B1 Transporter Q9Y6L6
TCMT279 VDR Vitamin D receptor Nuclear receptor P11473
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT341 NR1I2 Pregnane X receptor Nuclear receptor O75469
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT42 KMT2A Histone-lysine N-methyltransferase MLL Transferase Q03164
TCMT559 ADRB2 Beta-2 adrenergic receptor GPCR P07550
TCMT588 DAO D-amino-acid oxidase Oxidoreductase P14920
TCMT6 NFKB1 Nuclear factor NF-kappa-B p105 subunit Transcription factor P19838
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT64 PPARD Peroxisome proliferator-activated receptor delta Nuclear receptor Q03181
TCMT643 ADRA1A Alpha-1a adrenergic receptor GPCR P35348
TCMT647 ADRA2B Alpha-2b adrenergic receptor GPCR P18089
TCMT650 ADRA1B Alpha-1b adrenergic receptor GPCR P35368
TCMT67 PPARG Peroxisome proliferator-activated receptor gamma Nuclear receptor P37231
TCMT69 THRB Thyroid hormone receptor beta-1 Nuclear receptor P10828
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT796 PCNA Proliferating cell nuclear antigen Unclassified P12004
TCMT80 MAPK1 MAP kinase ERK2 Kinase P28482
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT864 THRA Thyroid hormone receptor alpha Nuclear receptor P10827


Targeted Pathogenic Microbes by the Ingredient of Component

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1176 Streptococcus pneumoniae
TCMT1177 Haemophilus influenzae
TCMT1193 Staphylococcus
TCMT1194 Shigella sonnei
TCMT1195 Streptococcus pasteurianus
TCMT1196 Salmonella
TCMT1197 Shigella sp.
TCMT1198 Serratia marcescens
TCMT1218 Staphylococcus aureus
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1243 Aspergillus flavus
TCMT1246 Escherichia coli
TCMT1251 Candida albicans
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1412 Salmonella typhimurium
TCMT1442 Leishmania donovani
TCMT1448 Enterobacter aerogenes
TCMT1454 Bacillus subtilis

Ingredient Structrues

Ingredient ID: TCMC953
Formula: C4H7N3O

Ingredient ID: TCMC903
Formula: C24H40O5

Ingredient ID: TCMC885
Formula: C16H17N3O4S

Ingredient ID: TCMC78
Formula: C11H20O6

Ingredient ID: TCMC453
Formula: C9H6O3

Ingredient ID: TCMC2011
Formula: C15H12I3NO4

Ingredient ID: TCMC1997
Formula: C9H13NO3

Ingredient ID: TCMC1830
Formula: C16H32O2

Ingredient ID: TCMC1797
Formula: C5H4N2O4

Ingredient ID: TCMC1758
Formula: C8H11NO3

Ingredient ID: TCMC1753
Formula: C18H21NO3

Ingredient ID: TCMC1504
Formula: C24H40O3

Ingredient ID: TCMC1498
Formula: C15H12I3NO4

Ingredient ID: TCMC1477
Formula: C15H11I4NO4

Ingredient ID: TCMC1459
Formula: C3H7NO2

Ingredient ID: TCMC138
Formula: C21H30O4

Ingredient ID: TCMC1209
Formula: C4H9NO2

Properties

Ingredient ID Formulae Name MW AlogP MlogP XlogP # HBA # HBD PSA # Rotatable Bond # Ring # Heacy Atom Lipinski RO5 Violation
TCMC78 C11H20O6 (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(2-Methylbut-3-En-2-Yloxy)Oxane-3,4,5-Triol 248.13 -0.9056 2.01 -0.356 6 4 99.38 10 1 17 0
TCMC138 C21H30O4 (8S,10R,11S,13S,14S,17S)-11-Hydroxy-17-(2-Hydroxyacetyl)-10,13-Dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-Dodecahydrocyclopenta[A]Phenanthren-3-One 346.21 -0.5211 3.33 1.704 4 2 74.6 6 4 25 0
TCMC453 C9H6O3 3-Hydroxycoumarin 162.03 -0.1864 2.12 3.054 2 1 46.53 1 2 12 0
TCMC885 C16H17N3O4S Cephalexin 347.09 -0.8185 2.34 -1.005 7 3 141.52 8 3 24 0
TCMC903 C24H40O5 Cholic Acid 408.29 -0.4664 3.55 4.093 5 4 97.99 11 4 29 0
TCMC953 C4H7N3O Creatinine 113.06 -0.7855 1.46 0.015 4 2 59.68 2 1 8 0
TCMC1209 C4H9NO2 Gamma-Aminobutyric Acid 103.06 -1.2313 1.57 -0.668 3 2 63.32 5 0 7 0
TCMC1459 C3H7NO2 L-Alanine 89.05 -1.0955 1.46 -2.824 3 2 63.32 4 0 6 0
TCMC1477 C15H11I4NO4 Levothyroxine 776.69 3.9816 2.12 2.847 3 3 92.78 12 2 24 0
TCMC1498 C15H12I3NO4 Liothyronine 650.79 2.5615 2.23 2.213 3 3 92.78 11 2 23 0
TCMC1504 C24H40O3 Lithocholic Acid 376.3 0.873 3.77 8.263 3 2 57.53 9 4 27 1
TCMC1753 C18H21NO3 Norarmepavine 299.15 -0.7051 3 2.755 1 2 50.72 7 3 22 0
TCMC1758 C8H11NO3 Norepinephrine 169.07 -2.1696 1.9 -0.46 2 4 86.71 6 1 12 0
TCMC1797 C5H4N2O4 Orotic Acid 156.02 -1.1604 1.35 -0.837 4 3 103.54 4 1 11 0
TCMC1830 C16H32O2 Palmitic Acid 256.24 -3.8977 3 7.57 2 1 37.3 16 0 18 2
TCMC1997 C9H13NO3 Racepinephrine 183.09 -1.7378 2.01 -0.07 2 4 72.72 7 1 13 0
TCMC2011 C15H12I3NO4 Reverse Triiodothyronine 650.79 2.5615 2.23 2.213 3 3 92.78 11 2 23 0

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