Component: Croton tiglium 巴豆霜


Description of the Component

Component ID
TCMH29
Latin Name
Croton tiglium
English Name
Defatted croton seed powder
Chinese Pinyin Name
Ba Dou Shuang
中文名
巴豆霜
TCM Properties
Hot,Pungent
TCM Meridians
Lung,Large Intestine,Stomach
Therapeutic Class English
Purging
Therapeutic Class Chinese
泻下
Functions
cause drastic purgation, relieve edema, soothe the throat
Toxicity
Slightly Toxic
Geo-authentic habitats (道地产区)
NA
Reference
Chinese Pharmacopoeia (2015)
Barcode ID
ITSAJ4152-14
Barcode Source
BOLDSYSTEMS

TCM Prescriptions with the Component

Prescription ID Prescription English Name Prescription Chinese Name
TCMF3033 Bai Xiao Pills 百效丸
TCMFx3258 Bao Chi Yi Li Jin Pills 保赤一粒金丸
TCMFx3249 Bao Chi Yi Li Jin Powder 保赤一粒金散
TCMFx1593 Baochi Powder 保赤散
TCMFx1230 Baochi Powder 保赤散
TCMFx3949 Chan Hou Powder 缠喉散
TCMFx3278 Dian Kuang Long Hu Pills 癫狂龙虎丸
TCMFx3743 Du Ji Du Jiao Ointment 杜记独角膏
TCMFx3918 Er Tong Qi Zhen Pills 儿童七珍丸
TCMFx4030 Jian Er Yao Tablets 健儿药片
TCMFx4393 Jing Feng Powder 惊风散
TCMFx4520 Jiu Long Hua Feng Pills 九龙化风丸
TCMFx4316 Niu Huang Yu Jin Pills 牛黄郁金丸
TCMFx5006 Qing Yu Bi Wen Dan 庆余辟瘟丹
TCMFx490 Qing Yu Pi Wen Dan 庆余辟瘟丹
TCMFx1344 Qizhen Pills 七珍丸
TCMFx2186 Qizhen Pills 七珍丸
TCMFx5646 Shang Ke Ba Li Powder 伤科八厘散
TCMFx5778 Tie Wa Powder 铁娃散
TCMF804 Wei Chang An Pills 胃肠安丸
TCMF5650 Wei Huo Ling Tablets 胃活灵片
TCMFx5802 Wei Tong Ding 胃痛定
TCMFx5826 Wei Tong Powder 胃痛散
TCMFx6046 Xiao Er Kang Jing Tablets 小儿抗惊片
TCMFx6220 Xiao Er Qi Feng Powder 小儿脐风散
TCMFx6205 Xiao Er Qi Zhen Pills 小儿七珍丸
TCMFx6198 Xiao Er Qi Zhen Tablets 小儿七珍片
TCMF6425 Xiao Er Xiao Ji Pills 小儿消积丸
TCMF6305 Yi Ba Zhua 一把抓
TCMFx6218 Ying Er Ping 婴儿平
TCMFx6215 Zhen Zhu Xiao Ji Pills 珍珠消积丸

Targeted Human Proteins by the Ingredient of Component

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT1 EHMT2 Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Transferase Q96KQ7
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT151 PRKCA Protein kinase C alpha Kinase P17252
TCMT152 PRKCB Protein kinase C beta Kinase P05771
TCMT153 PRKCG Protein kinase C gamma Kinase P05129
TCMT154 PRKCD Protein kinase C delta Kinase Q05655
TCMT155 PRKCE Protein kinase C epsilon Kinase Q02156
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT176 SOAT1 Acyl coenzyme A:cholesterol acyltransferase 1 Transferase P35610
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT248 CXCL8 Interleukin-8 Unclassified P10145
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT307 KCNH2 HERG Ion channel Q12809
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT341 NR1I2 Pregnane X receptor Nuclear receptor O75469
TCMT42 KMT2A Histone-lysine N-methyltransferase MLL Transferase Q03164
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT588 DAO D-amino-acid oxidase Oxidoreductase P14920
TCMT6 NFKB1 Nuclear factor NF-kappa-B p105 subunit Transcription factor P19838
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT64 PPARD Peroxisome proliferator-activated receptor delta Nuclear receptor Q03181
TCMT67 PPARG Peroxisome proliferator-activated receptor gamma Nuclear receptor P37231
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372


Targeted Pathogenic Microbes by the Ingredient of Component

Target ID Target Name
TCMT1218 Staphylococcus aureus
TCMT1251 Candida albicans
TCMT1346 Helicobacter pylori
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1455 Mycobacterium tuberculosis H37Rv

Ingredient Structrues

Ingredient ID: TCMC955
Formula: C4H6O2

Ingredient ID: TCMC897
Formula: C16H18O9

Ingredient ID: TCMC6831
Formula: C20H28O5

Ingredient ID: TCMC5713
Formula: C20H20O5

Ingredient ID: TCMC3966
Formula: C29H50O

Ingredient ID: TCMC3871
Formula: C20H28O6

Ingredient ID: TCMC3458
Formula: C5H8O2

Ingredient ID: TCMC3438
Formula: C36H56O8

Ingredient ID: TCMC3206
Formula: C10H13N5O5

Ingredient ID: TCMC2491
Formula: C3H6O2

Ingredient ID: TCMC2294
Formula: C5H5N5O

Ingredient ID: TCMC2105
Formula: C18H36O2

Ingredient ID: TCMC1881
Formula: C36H56O8

Ingredient ID: TCMC1830
Formula: C16H32O2

Ingredient ID: TCMC1788
Formula: C18H34O2

Ingredient ID: TCMC1679
Formula: C27H36O9

Ingredient ID: TCMC1678
Formula: C25H36O6

Ingredient ID: TCMC1677
Formula: C30H40O9

Ingredient ID: TCMC1676
Formula: C32H40O8

Ingredient ID: TCMC1675
Formula: C26H36O8

Ingredient ID: TCMC1672
Formula: C30H42O8

Ingredient ID: TCMC1627
Formula: C28H40O8

Ingredient ID: TCMC1623
Formula: C29H40O8

Ingredient ID: TCMC1496
Formula: C18H30O2

Ingredient ID: TCMC1495
Formula: C18H32O2

Ingredient ID: TCMC1101
Formula: C11H12O3

Ingredient ID: TCMC1081
Formula: C12H24O2

Properties

Ingredient ID Formulae Name MW AlogP MlogP XlogP # HBA # HBD PSA # Rotatable Bond # Ring # Heacy Atom Lipinski RO5 Violation
TCMC897 C16H18O9 Chlorogenic Acid 354.1 -2.1962 2.23 -0.447 7 6 164.75 11 2 25 1
TCMC955 C4H6O2 Crotonic Acid 86.04 0.5608 1.68 0.736 2 1 37.3 3 0 6 0
TCMC1081 C12H24O2 Dodecanoate 200.18 -2.7457 2.56 5.294 2 1 37.3 12 0 14 1
TCMC1101 C11H12O3 Elemicin 192.08 0.6742 2.34 2.486 0 0 27.69 4 2 14 0
TCMC1495 C18H32O2 Linoleic Acid 280.24 -0.9485 3.22 7.865 2 1 37.3 16 0 20 2
TCMC1496 C18H30O2 Linolenic Acid 278.22 -0.0979 3.22 7.538 2 1 37.3 15 0 20 2
TCMC1623 C29H40O8 516.27 1.7233 3.77 1.542 8 3 130.36 18 4 37 0
TCMC1627 C28H40O8 504.27 -0.7685 3.66 1.643 8 3 130.36 18 4 36 0
TCMC1672 C30H42O8 530.29 1.0471 3.88 2.111 8 3 130.36 19 4 38 0
TCMC1675 C26H36O8 476.24 0.3795 3.44 0.545 8 3 130.36 16 4 34 0
TCMC1676 C32H40O8 552.27 0.9012 4.1 2.176 8 3 130.36 17 5 40 0
TCMC1677 C30H40O9 544.27 0.3517 3.77 2.199 9 3 147.43 19 4 39 0
TCMC1678 C25H36O6 432.25 -0.0753 3.55 0.892 6 3 104.06 14 4 31 0
TCMC1679 C27H36O9 504.24 -0.9921 3.44 1.202 9 3 147.43 17 4 36 0
TCMC1788 C18H34O2 Oleic Acid 282.26 -2.3427 3.22 8.192 2 1 37.3 17 0 20 2
TCMC1830 C16H32O2 Palmitic Acid 256.24 -3.8977 3 7.57 2 1 37.3 16 0 18 2
TCMC1881 C36H56O8 Phorbol Myristate Acetate 616.4 -3.4367 4.54 6.511 8 3 130.36 26 4 44 2
TCMC2105 C18H36O2 Stearic Acid 284.27 -4.4737 3.22 8.708 2 1 37.3 18 0 20 2
TCMC2294 C5H5N5O Isoguanine 151.05 -1.6306 1.35 -1.132 5 3 100.71 2 2 11 0
TCMC2491 C3H6O2 Propionic Acid 74.04 -0.1537 1.57 0.173 2 1 37.3 3 0 5 0
TCMC3206 C10H13N5O5 Crotonoside 282.0838435 -3.1866 1.46 -2.227 10 4 155.55 2 3 20 0
TCMC3438 C36H56O8 Phorbol-12-Myristate-13-Acetate 616.3975188 -3.4367 4.54 6.511 8 3 130.36 17 4 44 2
TCMC3458 C5H8O2 Tiglic Acid 99.04460446 0.4361 1.79 0.436 2 0 40.13 1 0 7 0
TCMC3871 C20H28O6 Phorbol 364.1885886 -1.1031 3 -1.052 6 5 118.22 1 4 26 0
TCMC3966 C29H50O Sitosterol,Β-Sitosterol 414.3861662 1.3 4.54 11.595 1 1 20.23 6 4 30 1
TCMC5713 C20H20O5 Crotin 340.1310737 -0.6397 3.11 3.167 1 3 86.99 4 3 25 0
TCMC6831 C20H28O5 4-Deoxy-4Α-Phorbol 348.193674 -0.5026 3.11 -0.534 5 4 97.99 1 4 25 0

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