Component: Erycibe obtusifolia 丁公藤


Description of the Component

Component ID
 TCMH482
Latin Name
 Erycibe obtusifolia
English Name
 Obtuseleaf Erycibe Stem
Chinese Pinyin Name
 Ding Gong Teng
中文名
 丁公藤
TCM Properties
 Warm,Pungent
TCM Meridians
 Spleen,Stomach,Liver
Therapeutic Class English
Therapeutic Class Chinese
Functions
 dispel wind and deprive dampness, reduce swelling, relieve pain
Toxicity
 Toxic
Geo-authentic habitats (道地产区)
 NA
Reference
 Chinese Pharmacopoeia (2015)
Barcode ID
 MG730256
Barcode Source
 GenBank

TCM Prescriptions with the Component

Prescription ID Prescription English Name Prescription Chinese Name
TCMFx3472 Ding Gong Teng Zhu She Oral Liquid 丁公藤注射液
TCMFx3344 Feng Shi Bi Tong Yao Wine 风湿痹痛药酒
TCMF3604 Feng Tong Yao Wine 风痛药酒
TCMF2630 Fengliaoxing Fengshi Dieda Wine 冯了性风湿跌打药酒
TCMF1449 Fengliaoxing Fengshi Dieda Wine 冯了性风湿跌打药酒
TCMF2563 Fengliaoxing Medicated Wine 冯了性药酒
TCMF6920 Gu Tong Tie Ointment 骨通贴膏
TCMFx4869 Luo Fu Shan Feng Shi Gao Yao 罗浮山风湿膏药

Targeted Human Proteins by the Ingredient of Component

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT1 EHMT2 Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Transferase Q96KQ7
TCMT11 HIF1A Hypoxia-inducible factor 1 alpha Transcription factor Q16665
TCMT125 GBA Beta-glucocerebrosidase Hydrolase P04062
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT18 GAA Lysosomal alpha-glucosidase Hydrolase P10253
TCMT193 RELA Nuclear factor NF-kappa-B p65 subunit Transcription factor Q04206
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT225 CA13 Carbonic anhydrase XIII Lyase Q8N1Q1
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT31 CYP2C19 Cytochrome P450 2C19 Oxidoreductase P33261
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2


Targeted Pathogenic Microbes by the Ingredient of Component

Target ID Target Name
TCMT1090 Human immunodeficiency virus type 1 integrase
TCMT1108 Integrase
TCMT1346 Helicobacter pylori
TCMT1455 Mycobacterium tuberculosis H37Rv

Ingredient Structrues

Ingredient ID: TCMC897
Formula: C16H18O9

Ingredient ID: TCMC469
Formula: C25H24O12

Ingredient ID: TCMC418
Formula: C25H24O12

Ingredient ID: TCMC38
Formula: C19H21NO4

Ingredient ID: TCMC3546
Formula: C9H15NO3

Ingredient ID: TCMC2052
Formula: C16H18O9

Ingredient ID: TCMC2051
Formula: C10H8O4

Ingredient ID: TCMC1131
Formula: C9H6O4

Properties

Ingredient ID Formulae Name MW AlogP MlogP XlogP # HBA # HBD PSA # Rotatable Bond # Ring # Heacy Atom Lipinski RO5 Violation
TCMC38 C19H21NO4 (13Ar)-3,10-Dimethoxy-6,8,13,13A-Tetrahydro-5H-Isoquinolino[2,1-B]Isoquinoline-2,9-Diol 327.15 -0.7202 3 1.51 1 2 62.16 6 4 24 0
TCMC418 C25H24O12 3,4-Dicaffeoylquinic Acid 516.13 -2.3865 2.89 1.085 8 7 211.28 16 3 37 1
TCMC469 C25H24O12 4,5-Dicaffeoylquinic Acid 516.13 -2.3865 2.89 1.085 8 7 211.28 16 3 37 1
TCMC897 C16H18O9 Chlorogenic Acid 354.1 -2.1962 2.23 -0.447 7 6 164.75 11 2 25 1
TCMC1131 C9H6O4 Esculetin 178.03 -0.6506 2.01 0.998 1 2 66.76 2 2 13 0
TCMC2051 C10H8O4 Scopoletin 192.04 -0.2421 2.12 1.088 1 1 55.76 3 2 14 0
TCMC2052 C16H18O9 Scopolin 354.1 -1.989 2.23 -0.02 6 4 134.91 9 3 25 0
TCMC3546 C9H15NO3 Baogongteng C 186.1130184 -3.051 2.01 0.06 3 2 63.14 2 2 13 0

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1. General Information of the Component  
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3. Putative Targets  
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