TCM-ID Component

Description of the Component

Component ID	TCMH811
Latin Name	Lamprocapnos spectabilis
English Name	NA
Chinese Pinyin Name	He Bao Cao
中文名	荷包草
TCM Properties
TCM Meridians
Therapeutic Class English
Therapeutic Class Chinese
Functions
Toxicity	NA
Geo-authentic habitats (道地产区)	NA
Reference	Chinese Pharmacopoeia (2015)
Barcode ID	ITSAD220-14
Barcode Source	BOLDSYSTEMS

TCM Prescriptions with the Component

Prescription ID	Prescription English Name	Prescription Chinese Name
TCMFx5571	Qing Re Li Dan Infusion	清热利胆冲剂

Targeted Human Proteins by the Ingredient of Component

Target ID	Gene Symbol	Target Name	Target Class	Uniprot ID
TCMT1	EHMT2	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3	Transferase	Q96KQ7
TCMT11	HIF1A	Hypoxia-inducible factor 1 alpha	Transcription factor	Q16665
TCMT151	PRKCA	Protein kinase C alpha	Kinase	P17252
TCMT152	PRKCB	Protein kinase C beta	Kinase	P05771
TCMT153	PRKCG	Protein kinase C gamma	Kinase	P05129
TCMT154	PRKCD	Protein kinase C delta	Kinase	Q05655
TCMT155	PRKCE	Protein kinase C epsilon	Kinase	Q02156
TCMT175	GPBAR1	G-protein coupled bile acid receptor 1	GPCR	Q8TDU6
TCMT194	MAP3K7	Mitogen-activated protein kinase kinase kinase 7	Kinase	O43318
TCMT195	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1	Kinase	Q02750
TCMT196	MAP2K7	Dual specificity mitogen-activated protein kinase kinase 7	Kinase	O14733
TCMT2	MAPT	Microtubule-associated protein tau	Unclassified	P10636
TCMT212	SRC	Tyrosine-protein kinase SRC	Kinase	P12931
TCMT226	PDPK1	3-phosphoinositide dependent protein kinase-1	Kinase	O15530
TCMT239	PIM1	Serine/threonine-protein kinase PIM1	Kinase	P11309
TCMT260	FLT3	Tyrosine-protein kinase receptor FLT3	Kinase	P36888
TCMT261	DAPK1	Death-associated protein kinase 1	Kinase	P53355
TCMT265	GSK3B	Glycogen synthase kinase-3 beta	Kinase	P49841
TCMT27	DRD1	Dopamine D1 receptor	GPCR	P21728
TCMT273	NR1H4	Bile acid receptor FXR	Nuclear receptor	Q96RI1
TCMT276	SLCO2B1	Solute carrier organic anion transporter family member 2B1	Transporter	O94956
TCMT277	SLCO1B3	Solute carrier organic anion transporter family member 1B3	Transporter	Q9NPD5
TCMT278	SLCO1B1	Solute carrier organic anion transporter family member 1B1	Transporter	Q9Y6L6
TCMT279	VDR	Vitamin D receptor	Nuclear receptor	P11473
TCMT3	ALOX15	Arachidonate 15-lipoxygenase	Oxidoreductase	P16050
TCMT31	CYP2C19	Cytochrome P450 2C19	Oxidoreductase	P33261
TCMT33	CYP3A4	Cytochrome P450 3A4	Oxidoreductase	P08684
TCMT34	CYP2D6	Cytochrome P450 2D6	Oxidoreductase	P10635
TCMT354	AURKA	Serine/threonine-protein kinase Aurora-A	Kinase	O14965
TCMT355	CSNK1D	Casein kinase I delta	Kinase	P48730
TCMT359	FYN	Tyrosine-protein kinase FYN	Kinase	P06241
TCMT36	HTR1A	Serotonin 1a (5-HT1a) receptor	GPCR	P08908
TCMT369	IGF1R	Insulin-like growth factor I receptor	Kinase	P08069
TCMT37	HTR2A	Serotonin 2a (5-HT2a) receptor	GPCR	P28223
TCMT370	KDR	Vascular endothelial growth factor receptor 2	Kinase	P35968
TCMT374	AURKB	Serine/threonine-protein kinase Aurora-B	Kinase	Q96GD4
TCMT377	INSR	Insulin receptor	Kinase	P06213
TCMT378	LIMK1	LIM domain kinase 1	Kinase	P53667
TCMT38	DRD2	Dopamine D2 receptor	GPCR	P14416
TCMT384	GRK6	G protein-coupled receptor kinase 6	Kinase	P43250
TCMT388	AXL	Tyrosine-protein kinase receptor UFO	Kinase	P30530
TCMT393	MERTK	Proto-oncogene tyrosine-protein kinase MER	Kinase	Q12866
TCMT401	MET	Hepatocyte growth factor receptor	Kinase	P08581
TCMT402	ALK	ALK tyrosine kinase receptor	Kinase	Q9UM73
TCMT407	MYLK	Myosin light chain kinase, smooth muscle	Kinase	Q15746
TCMT417	DYRK2	Dual-specificity tyrosine-phosphorylation regulated kinase 2	Kinase	Q92630
TCMT418	EPHB4	Ephrin type-B receptor 4	Kinase	P54760
TCMT422	CAMK2B	CaM kinase II beta	Kinase	Q13554
TCMT423	EGFR	Epidermal growth factor receptor erbB1	Kinase	P00533
TCMT434	JAK2	Tyrosine-protein kinase JAK2	Kinase	O60674
TCMT436	NUAK1	NUAK family SNF1-like kinase 1	Kinase	O60285
TCMT441	PTK2	Focal adhesion kinase 1	Kinase	Q05397
TCMT445	NEK2	Serine/threonine-protein kinase NEK2	Kinase	P51955
TCMT457	FLT4	Vascular endothelial growth factor receptor 3	Kinase	P35916
TCMT458	HASPIN	Serine/threonine-protein kinase haspin	Kinase	Q8TF76
TCMT460	MAPKAPK2	MAP kinase-activated protein kinase 2	Kinase	P49137
TCMT462	NEK6	Serine/threonine-protein kinase NEK6	Kinase	Q9HC98
TCMT466	MAPK9	c-Jun N-terminal kinase 2	Kinase	P45984
TCMT473	PIM3	Serine/threonine-protein kinase PIM3	Kinase	Q86V86
TCMT479	AKT1	Serine/threonine-protein kinase AKT	Kinase	P31749
TCMT484	PLK1	Serine/threonine-protein kinase PLK1	Kinase	P53350
TCMT502	TEK	Tyrosine-protein kinase TIE-2	Kinase	Q02763
TCMT506	PTK2B	Protein tyrosine kinase 2 beta	Kinase	Q14289
TCMT507	MAPK14	MAP kinase p38 alpha	Kinase	Q16539
TCMT508	SYK	Tyrosine-protein kinase SYK	Kinase	P43405
TCMT510	KIT	Stem cell growth factor receptor	Kinase	P10721
TCMT536	PDGFRB	Platelet-derived growth factor receptor beta	Kinase	P09619
TCMT6	NFKB1	Nuclear factor NF-kappa-B p105 subunit	Transcription factor	P19838
TCMT613	NR3C1	Glucocorticoid receptor	Nuclear receptor	P04150
TCMT69	THRB	Thyroid hormone receptor beta-1	Nuclear receptor	P10828
TCMT8	KDM4E	Lysine-specific demethylase 4D-like	Oxidoreductase	B2RXH2
TCMT80	MAPK1	MAP kinase ERK2	Kinase	P28482
TCMT81	ALOX12	Arachidonate 12-lipoxygenase	Oxidoreductase	P18054
TCMT87	CYP2C9	Cytochrome P450 2C9	Oxidoreductase	P11712

Targeted Pathogenic Microbes by the Ingredient of Component

Target ID	Target Name
TCMT1218	Staphylococcus aureus
TCMT1229	Enterococcus faecalis

Ingredient Structrues

Ingredient ID: TCMC892
Formula: C21H18NO4

Common Name	Chelerythrine
IUPAC Name	1,2-dimethoxy-12-methyl-[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium
Canonical SMILES	COc1c(OC)ccc2c1c[n+](C)c1c2ccc2c1cc1OCOc1c2
Standard InCHI	InChI=1S/C21H18NO4/c1-22-10-16-13(6-7-17(23-2)21(16)24-3)14-5-4-12-8-18-19(26-11-25-18)9-15(12)20(14)22/h4-10H,11H2,1-3H3/q+1
Standard InCHIKey	LLEJIEBFSOEYIV-UHFFFAOYSA-N
External Identifiers	ChEMBL [CHEMBL13045]; PubChem [2703];
Reference of Component-Ingredient Pair	24014644

Occurrence of the ingredient across TCM components

Component ID	Latin Name	Pinyin Name	Chinese Name
TCMH924	Zanthoxylum bungeanum	Hua Jiao	花椒
TCMH811	Lamprocapnos spectabilis	He Bao Cao	荷包草
TCMH101	Chelidonium majus	Bai Qu Cai	白屈菜
TCMH1460	Zanthoxylum nitidum	Mao Liang Mian Zhen	毛两面针

Ingredient ID: TCMC38
Formula: C19H21NO4

Common Name	(13Ar)-3,10-Dimethoxy-6,8,13,13A-Tetrahydro-5H-Isoquinolino[2,1-B]Isoquinoline-2,9-Diol
IUPAC Name	(13aR)-3,10-dimethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline-2,9-diol
Canonical SMILES	COc1cc2CCN3[C@@H](c2cc1O)Cc1c(C3)c(O)c(cc1)OC
Standard InCHI	InChI=1S/C19H21NO4/c1-23-17-4-3-11-7-15-13-9-16(21)18(24-2)8-12(13)5-6-20(15)10-14(11)19(17)22/h3-4,8-9,15,21-22H,5-7,10H2,1-2H3/t15-/m1/s1
Standard InCHIKey	KNWVMRVOBAFFMH-OAHLLOKOSA-N
External Identifiers	ChEMBL [CHEMBL1395394]; PubChem [1152279];
Reference of Component-Ingredient Pair	N/A

Occurrence of the ingredient across TCM components

Component ID	Latin Name	Pinyin Name	Chinese Name
TCMH811	Lamprocapnos spectabilis	He Bao Cao	荷包草
TCMH1165	Murraya paniculata	Jiu Li Xiang	九里香
TCMH2515	Papaver somniferum	Ying Su Ke	罂粟壳
TCMH482	Erycibe obtusifolia	Ding Gong Teng	丁公藤
TCMH1205	Corydalis bungeana	Ku Di Ding	苦地丁
TCMH2376	Corydalis yanhusuo	Yan Hu Suo	延胡索
TCMH444	Corydalis bungeana	Di Ding	地丁
TCMH1489	Papaver somniferum	Mi Ying Su Ke	蜜罂粟壳
TCMH2514	Papaver somniferum	Ying Su	罂粟

Ingredient ID: TCMC2215
Formula: C24H40O4

Common Name	Ursodiol
IUPAC Name	(4R)-4-[(3R,5S,7S,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid
Canonical SMILES	O[C@@H]1CC[C@]2([C@@H](C1)C[C@@H]([C@@H]1[C@@H]2CC[C@]2([C@H]1CC[C@@H]2[C@@H](CCC(=O)O)C)C)O)C
Standard InCHI	InChI=1S/C24H40O4/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15+,16-,17-,18+,19+,20+,22+,23+,24-/m1/s1
Standard InCHIKey	RUDATBOHQWOJDD-UZVSRGJWSA-N
External Identifiers	ChEMBL [CHEMBL1551]; PubChem [31401];
Reference of Component-Ingredient Pair	N/A

Occurrence of the ingredient across TCM components

Component ID	Latin Name	Pinyin Name	Chinese Name
TCMH811	Lamprocapnos spectabilis	He Bao Cao	荷包草
TCMH101	Chelidonium majus	Bai Qu Cai	白屈菜
TCMH2710	Homo sapiens	Zi He Che	紫河车
TCMH1734	Homo sapiens	Ren Zhong Bai	人中白

Properties

Ingredient ID	Formulae	Name	MW	AlogP	MlogP	XlogP	# HBA	# HBD	PSA	# Rotatable Bond	# Ring	# Heacy Atom	Lipinski RO5 Violation
TCMC38	C19H21NO4	(13Ar)-3,10-Dimethoxy-6,8,13,13A-Tetrahydro-5H-Isoquinolino[2,1-B]Isoquinoline-2,9-Diol	327.15	-0.7202	3	1.51	1	2	62.16	6	4	24	0
TCMC892	C21H18NO4	Chelerythrine	348.12	-1.7479	3.22	3.37	0	0	40.8	5	5	26	0
TCMC2215	C24H40O4	Ursodiol	392.29	0.1067	3.66	6.178	4	3	77.76	10	4	28	1

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1. General Information of the Component
2. TCM Prescriptions with the Component
3. Putative Targets
4. Activity & References for Filtering Putative Targets
5. Ingredient Data & Chemical Structure Information (Properties, InChI, InChIkey, SMILES, etc.)

Component: Lamprocapnos spectabilis 荷包草

Description of the Component

Component ID

Latin Name

English Name

Chinese Pinyin Name

中文名

TCM Properties

TCM Meridians

Therapeutic Class English

Therapeutic Class Chinese

Functions

Toxicity

Geo-authentic habitats (道地产区)

Reference

Barcode ID

Barcode Source

TCM Prescriptions with the Component

Targeted Human Proteins by the Ingredient of Component

Targeted Pathogenic Microbes by the Ingredient of Component

Ingredient Structrues

Ingredient ID: TCMC892

Occurrence of the ingredient across TCM components

Ingredient ID: TCMC38

Occurrence of the ingredient across TCM components

Ingredient ID: TCMC2215

Occurrence of the ingredient across TCM components

Properties

Download Data