Component: Sargentodoxa cuneata 大血藤


Description of the Component

Component ID
TCMH385
Latin Name
Sargentodoxa cuneata
English Name
Sargentgloryvine
Chinese Pinyin Name
Da Xue Teng
中文名
大血藤
TCM Properties
Mild,Bitter,Punkery
TCM Meridians
Large Intestine,Liver
Therapeutic Class English
Heat clearence
Therapeutic Class Chinese
清热
Functions
remove toxic heat, promote blood circulation, and relieve rheumatic conditions
Toxicity
NA
Geo-authentic habitats (道地产区)
NA
Reference
Chinese Pharmacopoeia (2015)
Barcode ID
ITSAG360-14
Barcode Source
BOLDSYSTEMS

TCM Prescriptions with the Component

Prescription ID Prescription English Name Prescription Chinese Name
TCMF2219 Appendictis Tablet 阑尾消炎片
TCMF3807 Du Zhong Zhuang Gu Capsules 杜仲壮骨胶囊
TCMF3815 Du Zhong Zhuang Gu Pills 杜仲壮骨丸
TCMF3462 Feng Shi Ning Yao Wine 风湿宁药酒
TCMF540 Fu Bao Granules 妇宝颗粒
TCMF3764 Fu Bao Granules 妇宝颗粒
TCMF3985 Fu Le Granules 妇乐颗粒
TCMF3977 Fu Le Infusion 妇乐冲剂
TCMFx6998 Fu Ping Capsules 妇平胶囊
TCMF7219 Fu Yan Shu Capsules 妇炎舒胶囊
TCMF536 Fu Le Granules 妇乐颗粒
TCMF3522 Gu Tong Yao Wine 骨痛药酒
TCMFx7153 Jin Gu Lian Tablets 金骨莲片
TCMF4738 Lan Wei Xiao Yan Tablets 阑尾消炎片
TCMFx4861 Qi She Feng Shi Wine 蕲蛇风湿酒
TCMFx5121 San Qi Yao Wine 三七药酒
TCMF5164 San She Yao Wine 三蛇药酒
TCMFx5474 Shan Long Yao Wine 山龙药酒
TCMFx5753 Shang Shi Zhen Tong Ointment 伤湿镇痛膏
TCMFx5358 Shen Nong Yao Wine 神农药酒
TCMFx5433 Shen Zhou Die Da Pills 神州跌打丸
TCMFx6705 Yi Wei Ointment 益胃膏
TCMFx6711 Yi Wei Oral Liquid 益胃口服液

Targeted Human Proteins by the Ingredient of Component

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT1 EHMT2 Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Transferase Q96KQ7
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT143 CA3 Carbonic anhydrase III Lyase P07451
TCMT151 PRKCA Protein kinase C alpha Kinase P17252
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT18 GAA Lysosomal alpha-glucosidase Hydrolase P10253
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT22 ALPI Intestinal alkaline phosphatase Hydrolase P09923
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT225 CA13 Carbonic anhydrase XIII Lyase Q8N1Q1
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT281 DPP4 Dipeptidyl peptidase IV Unclassified P27487
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT320 MMP3 Matrix metalloproteinase 3 Hydrolase P08254
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT41 IDH1 Isocitrate dehydrogenase [NADP] cytoplasmic Oxidoreductase O75874
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT6 NFKB1 Nuclear factor NF-kappa-B p105 subunit Transcription factor P19838
TCMT60 FASN Fatty acid synthase Unclassified P49327
TCMT601 F2 Thrombin Unclassified P00734
TCMT609 CTSL Cathepsin L Unclassified P07711
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT80 MAPK1 MAP kinase ERK2 Kinase P28482
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907


Targeted Pathogenic Microbes by the Ingredient of Component

Target ID Target Name
TCMT1088 Carbonic anhydrase
TCMT1104 Sortase
TCMT1175 Human immunodeficiency virus
TCMT1189 Pseudomonas fluorescens
TCMT1212 Verticillium dahliae
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1232 Pseudomonas aeruginosa
TCMT1246 Escherichia coli
TCMT1251 Candida albicans
TCMT1346 Helicobacter pylori
TCMT1438 Plasmodium falciparum
TCMT1454 Bacillus subtilis
TCMT1463 Mycobacterium tuberculosis
TCMT1465 Entamoeba histolytica

Ingredient Structrues

Ingredient ID: TCMC995
Formula: C35H60O6

Ingredient ID: TCMC913
Formula: C15H14O6

Ingredient ID: TCMC898
Formula: C17H20O9

Ingredient ID: TCMC897
Formula: C16H18O9

Ingredient ID: TCMC878
Formula: C15H14O6

Ingredient ID: TCMC852
Formula: C23H26O11

Ingredient ID: TCMC801
Formula: C29H50O

Ingredient ID: TCMC714
Formula: C9H10O3

Ingredient ID: TCMC6326
Formula: C23H26O13

Ingredient ID: TCMC5765
Formula: C24H40O11

Ingredient ID: TCMC5761
Formula: C14H18O8

Ingredient ID: TCMC5740
Formula: C14H18O8

Ingredient ID: TCMC5727
Formula: C19H28O12

Ingredient ID: TCMC5722
Formula: C19H28O12

Ingredient ID: TCMC5237
Formula: C20H28O12

Ingredient ID: TCMC4854
Formula: C14H20O7

Ingredient ID: TCMC3966
Formula: C29H50O

Ingredient ID: TCMC3711
Formula: C19H28O11

Ingredient ID: TCMC3563
Formula: C14H20O7

Ingredient ID: TCMC3233
Formula: C35H60O6

Ingredient ID: TCMC2467
Formula: C29H48O2

Ingredient ID: TCMC24
Formula: C15H14O6

Ingredient ID: TCMC2222
Formula: C8H8O4

Ingredient ID: TCMC2201
Formula: C8H10O2

Ingredient ID: TCMC1956
Formula: C7H6O4

Ingredient ID: TCMC1886
Formula: C18H18O5

Ingredient ID: TCMC1352
Formula: C8H10O3

Ingredient ID: TCMC13
Formula: C15H14O6

Properties

Ingredient ID Formulae Name MW AlogP MlogP XlogP # HBA # HBD PSA # Rotatable Bond # Ring # Heacy Atom Lipinski RO5 Violation
TCMC13 C15H14O6 (-)-Epicatechin 290.08 -2.494 2.45 0.406 1 5 110.38 6 3 21 0
TCMC24 C15H14O6 (+)-Epicatechin 290.08 -2.494 2.45 0.406 1 5 110.38 6 3 21 0
TCMC714 C9H10O3 Apocynin 166.06 -0.766 2.12 0.891 1 1 46.53 5 1 12 0
TCMC801 C29H50O Beta-Sitosterol 414.39 1.3 4.54 11.595 1 1 20.23 13 4 30 1
TCMC852 C23H26O11 Calceolarioside B 478.15 -3.0509 2.78 1.061 7 7 186.37 16 3 34 1
TCMC878 C15H14O6 Catechin 290.08 -2.494 2.45 0.406 1 5 110.38 6 3 21 0
TCMC897 C16H18O9 Chlorogenic Acid 354.1 -2.1962 2.23 -0.447 7 6 164.75 11 2 25 1
TCMC898 C17H20O9 Chlorogenic Acid Methyl Ester 368.11 -1.9452 2.34 -0.126 7 5 153.75 12 2 26 0
TCMC913 C15H14O6 Cianidanol 290.08 -2.494 2.45 0.406 1 5 110.38 6 3 21 0
TCMC995 C35H60O6 Daucosterol 576.44 -0.4469 4.65 10.487 6 4 99.38 19 5 41 1
TCMC1352 C8H10O3 Hydroxytyrosol 154.06 -1.1137 2.01 0.637 1 3 60.69 5 1 11 0
TCMC1886 C18H18O5 P-Hydroxyphenethyl Trans-Ferulate 314.12 -0.4352 2.89 3.222 2 2 75.99 10 2 23 0
TCMC1956 C7H6O4 Protocatechuic Acid 154.03 -1.1604 1.79 0.536 2 3 77.76 4 1 11 0
TCMC2201 C8H10O2 Tyrosol 138.07 -0.6534 2.12 1.171 1 2 40.46 4 1 10 0
TCMC2222 C8H8O4 Vanillic Acid 168.04 -0.7519 1.9 0.626 2 2 66.76 5 1 12 0
TCMC2467 C29H48O2 Saringosterol 428.37 1.8051 4.43 8.59 2 2 40.46 13 4 31 1
TCMC3233 C35H60O6 Alexandrin,Daucosterol,Eleutheroside A 576.4389896 -0.4469 4.65 10.487 6 4 99.38 9 5 41 1
TCMC3563 C14H20O7 Rhodioloside,Salidroside 300.120903 -2.4003 2.23 0.063 6 5 119.61 5 2 21 0
TCMC3711 C19H28O11 Osmanthuside H 432.1631617 -3.809 2.34 -1.274 10 7 178.53 8 3 30 1
TCMC3966 C29H50O Sitosterol,Β-Sitosterol 414.3861662 1.3 4.54 11.595 1 1 20.23 6 4 30 1
TCMC4854 C14H20O7 Sargencuneside 300.120903 -1.617 2.23 0.393 5 4 108.61 4 2 21 0
TCMC5237 C20H28O12 2-Methoxy-4-Acetylphenyl-1-O-Β-D-Apiofuranosyl-(1''→6')-Β-Glucopyranoside 460.1580763 -3.9216 2.34 -1.554 10 6 184.6 8 3 32 1
TCMC5722 C19H28O12 Cuneataside C 448.1580763 -4.2693 2.23 -1.808 10 8 198.76 8 3 31 1
TCMC5727 C19H28O12 Cuneataside D 448.1580763 -3.9662 2.23 -1.516 9 7 187.76 6 3 31 1
TCMC5740 C14H18O8 Cuneataside A 314.1001675 -2.8604 2.12 -0.912 6 5 128.84 2 3 22 0
TCMC5761 C14H18O8 Cuneataside B 314.1001675 -2.8604 2.12 -0.912 6 5 128.84 2 3 22 0
TCMC5765 C24H40O11 Cuneataside E 504.2570621 -2.0654 2.89 -1.168 11 6 175.37 9 3 35 2
TCMC6326 C23H26O13 1-O-Vanillic Acid-6-O-(3'',5''-Dimethoxy-Galloyl)-Β-D-Glycoside 509.1295159 -3.3713 2.56 -0.39 8 4 193.5 10 3 36 0

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1. General Information of the Component  
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