Component: Strychnos nux-vomica 马钱子


Description of the Component

Component ID
TCMH1405
Latin Name
Strychnos nux-vomica
English Name
Nut-vomitive poisonnut
Chinese Pinyin Name
Ma Qian Zi
中文名
马钱子
TCM Properties
Cold,Bitter
TCM Meridians
Spleen,Liver
Therapeutic Class English
Blood activation and stasis removal
Therapeutic Class Chinese
活血化淤
Functions
promote the flow of qi and blood in the collaterals, relieve pain, and promote the subsidence of swelling
Toxicity
Extremely Toxic
Geo-authentic habitats (道地产区)
Yunnan Province
Reference
Chinese Pharmacopoeia (2015)
Barcode ID
PPBI045-16
Barcode Source
BOLDSYSTEMS

TCM Prescriptions with the Component

Prescription ID Prescription English Name Prescription Chinese Name
TCMFx3168 Bai Hua Huo Xue Die Da Ointment 百花活血跌打膏
TCMFx2990 Bai Hua She Ointment 白花蛇膏
TCMF3234 Bao Zhen Ointment 宝珍膏
TCMFx2159 Bone Piercing Bolus 骨刺丸
TCMFx1340 Bone Piercing Bolus 骨刺丸
TCMFx2517 Brain Strengthening Powder 健脑散
TCMFx3012 Chan Su Zhen Tong Ointment 蟾酥镇痛膏
TCMFx3418 Die Da Wan Hua You 跌打万花油
TCMF3434 Die Da Zhen Tong Ointment 跌打镇痛膏
TCMF1038 Die Da Zhen Tong Ointment 跌打镇痛膏
TCMFx3449 Die Da Zhi Tong Powder 跌打止痛散
TCMFx3441 Die Da Zhi Tong Tablets 跌打止痛片
TCMFx412 Feng Han Shuang Li Guai Tablet 风寒双离拐片
TCMFx3292 Feng Han Shuang Li Guai Tablets 风寒双离拐片
TCMFx3337 Feng Shi An Tai Tablets 风湿安泰片
TCMFx3365 Feng Shi Fu Yin Pills 风湿福音丸
TCMF3416 Feng Shi Guan Jie Yan Pills 风湿关节炎丸
TCMF3407 Feng Shi Guan Jie Yan Tablets 风湿关节炎片
TCMFx3448 Feng Shi Ma Qian Tablets 风湿马钱片
TCMFx3471 Feng Shi Tablets 风湿片
TCMF3548 Feng Shi Zhen Tong Pills 风湿镇痛丸
TCMF3582 Feng Tong Ning Tablets 风痛宁片
TCMF3590 Feng Tong Tablets 风痛片
TCMFx3150 Fu Fang Xia Tian Wu Tablets 复方夏天无片
TCMF3401 Gu Ci Tablets 骨刺片
TCMF3458 Gu Jin Pills 骨筋丸
TCMF3466 Gu Jin Wan Capsules 骨筋丸胶囊
TCMF3473 Gu Jin Wan Tablets 骨筋丸片
TCMFx3695 Guan Jie Yan Ointment 关节炎膏
TCMFx4209 Han Bi Ting Tablets 寒痹停片
TCMFx4219 Han Chuan Gao Yao 寒喘膏药
TCMFx4762 Hu Po Zhi Tong Ointment 琥珀止痛膏
TCMFx4640 Jie Gu Pills 接骨丸
TCMFx4069 Jin Qian Bai Hua She Yao Wine 金钱白花蛇药酒
TCMFx1692 Jiufen Powder 九分散
TCMFx1246 Jiufen Powder; Nine Fen Powder 九分散
TCMFx1957 June First BZS Sesame Soup
TCMFx4211 Kang Shuan Capsules 抗栓胶囊
TCMFx4458 Liu Tiao Ointment 柳条膏
TCMFx4978 Lv Ying Ointment 绿樱膏
TCMFx4071 Ma Qian Zi Powder 马钱子散
TCMFx1512 Maqianzi Powder 马钱子散
TCMFx1215 Maqianzi Powder 马钱子散
TCMFx4646 Ping Xiao Capsules 平消胶囊
TCMFx4654 Ping Xiao Tablets 平消片
TCMFx5096 Qiang Jin Ying Xiong Pills 强筋英雄丸
TCMF5390 Qing Liang Gao Yao 清凉膏药
TCMFx1980 Relaxing Muscles and Tendons Capsule 伸筋丹胶囊
TCMFx1304 Relaxing Muscles and Tendons Capsule 伸筋丹胶囊
TCMF5513 Shan Yao Pills 山药丸
TCMFx5677 Shang Ke Jie Gu Tablets 伤科接骨片
TCMF5686 Shang Ke Qi Wei Tablets 伤科七味片
TCMFx5694 Shang Ke Wan Hua You 伤科万花油
TCMFx5810 Shang Tong Shu 伤痛舒
TCMF1435 Shangshi Zhitong Plaster 伤湿止痛膏
TCMF2614 Shangshi Zhitong Plaster 伤湿止痛膏
TCMFx5076 She Xiang Die Da Feng Shi Ointment 麝香跌打风湿膏
TCMF5083 She Xiang Die Da Ruan Ointment 麝香跌打软膏
TCMF5123 She Xiang Hai Ma Zhui Feng Ointment 麝香海马追风膏
TCMFx5154 She Xiang Jie Gu Capsules 麝香接骨胶囊
TCMFx5312 Shen Jin Dan Capsules 伸筋丹胶囊
TCMFx5319 Shen Jin Huo Luo Pills 伸筋活络丸
TCMFx556 Shen Jin Huo Luo Pills 伸筋活络丸
TCMFx5366 Shen Nong Zhen Tong Ointment 神农镇痛膏
TCMFx5725 Sheng Li Xiong Pills 生力雄丸
TCMF5573 Shu Feng Ding Tong Pills 疏风定痛丸
TCMF5589 Shu Feng Huo Luo Pills 疏风活络丸
TCMF5582 Shu Feng Huo Luo Tablets 疏风活络片
TCMF1145 Shu Feng Huo Luo Pills 疏风活络丸
TCMF5424 Shu Jin Huo Xue Pills 舒筋活血丸
TCMF5440 Shu Jin Pills 舒筋丸
TCMF5478 Shu Luo Yang Gan Pills 舒络养肝丸
TCMF1418 Shufeng Dingtong Pills 疏风定痛丸
TCMF2577 Shufeng Dingtong Pills 疏风定痛丸
TCMF2578 Shujin Pills 舒筋丸
TCMF1419 Shujin Pills 舒筋丸
TCMF1062 Tian Meng Capsule 甜梦胶囊
TCMF5583 Tian Meng Capsules 甜梦胶囊
TCMF5590 Tian Meng Oral Liquid 甜梦口服液
TCMF106 Tian Meng Oral Liquid 甜梦口服液
TCMFx5739 Tiao Gu Tablets 跳骨片
TCMFx982 Tong Bi Capsule 通痹胶囊
TCMFx5279 Wai Yong Die Da Zhi Tong Ointment 外用跌打止痛膏
TCMFx5293 Wai Yong Wu Di Ointment 外用无敌膏
TCMFx5347 Wan Ling Wu Xiang Ointment 万灵五香膏
TCMFx5588 Wu Xiang Shang Ointment 五香伤膏
TCMF6014 Xiao Er Tong Ding 消尔痛酊
TCMFx6045 Xiao He Ointment 消核膏
TCMFx6483 Xiao Zhong Tablets 消肿片
TCMF6022 Yang Xue Qu Feng Pills 养血祛风丸
TCMFx6148 Yao Tong Ning Capsules 腰痛宁胶囊
TCMF6171 Yao Tui Tong Pills 腰腿痛丸
TCMFx6701 Yi Sui Infusion 益髓冲剂
TCMF6465 Yu Jin Yin Xie Tablets 郁金银屑片
TCMFx6250 Zhen Jiang Gao Yao 镇江膏药
TCMFx6255 Zhen Jiang Xiang Jiao Ointment 镇江橡胶膏
TCMFx6109 Zhi Shang Xiao Yu Pills 治伤消瘀丸
TCMF6627 Zhi Tong Feng Shi Pills 止痛风湿丸
TCMFx6365 Zhu Shi A Wei Xiao Pi Ointment 朱氏阿魏消痞膏
TCMF6484 Zhuang Gu She Xiang Zhi Tong Ointment 壮骨麝香止痛膏
TCMF6617 Zhui Feng Huo Xue Ointment 追风活血膏
TCMF6641 Zhui Feng Shu Jing Huo Xue Tablets 追风舒经活血片
TCMF6763 Zi Yin Bu Shen Pills 滋阴补肾丸

Targeted Human Proteins by the Ingredient of Component

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT1 EHMT2 Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Transferase Q96KQ7
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT281 DPP4 Dipeptidyl peptidase IV Unclassified P27487
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT41 IDH1 Isocitrate dehydrogenase [NADP] cytoplasmic Oxidoreductase O75874
TCMT45 APP Beta amyloid A4 protein Unclassified P05067


Targeted Pathogenic Microbes by the Ingredient of Component

Target ID Target Name
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1248 Hepatitis C virus
TCMT1346 Helicobacter pylori
TCMT1438 Plasmodium falciparum
TCMT1465 Entamoeba histolytica

Ingredient Structrues

Ingredient ID: TCMC897
Formula: C16H18O9

Ingredient ID: TCMC801
Formula: C29H50O

Ingredient ID: TCMC7269
Formula: C22H24N2O4

Ingredient ID: TCMC7268
Formula: C22H24N2O4

Ingredient ID: TCMC7078
Formula: C18H26O11

Ingredient ID: TCMC6551
Formula: C21H22N2O3

Ingredient ID: TCMC6541
Formula: C22H24N2O4

Ingredient ID: TCMC6540
Formula: C22H24N2O4

Ingredient ID: TCMC6539
Formula: C21H22N2O3

Ingredient ID: TCMC6412
Formula: C21H22N2O3

Ingredient ID: TCMC6408
Formula: C20H25N2O

Ingredient ID: TCMC6399
Formula: C27H33N2O9

Ingredient ID: TCMC6363
Formula: C23H26N2O5

Ingredient ID: TCMC5943
Formula: C24H28N2O5

Ingredient ID: TCMC5930
Formula: C17H24O10

Ingredient ID: TCMC5884
Formula: C22H24N2O3

Ingredient ID: TCMC5843
Formula: C19H28O11

Ingredient ID: TCMC5775
Formula: C18H26O11

Ingredient ID: TCMC5689
Formula: C18H26O11

Ingredient ID: TCMC5677
Formula: C18H26O11

Ingredient ID: TCMC5676
Formula: C19H22N2O

Ingredient ID: TCMC5567
Formula: C21H22N2O2

Ingredient ID: TCMC5555
Formula: C21H26N2O2

Ingredient ID: TCMC5489
Formula: C28H33N2O9

Ingredient ID: TCMC5472
Formula: C27H31N2O9

Ingredient ID: TCMC5295
Formula: C27H34N2O9

Ingredient ID: TCMC4251
Formula: C22H24N2O3

Ingredient ID: TCMC4245
Formula: C23H26N2O5

Ingredient ID: TCMC4129
Formula: C20H24N2O2

Ingredient ID: TCMC4078
Formula: C40H40N4O2

Ingredient ID: TCMC3823
Formula: C17H26O9

Ingredient ID: TCMC3752
Formula: C22H24N2O3

Ingredient ID: TCMC3563
Formula: C14H20O7

Ingredient ID: TCMC3384
Formula: C22H24N2O4

Ingredient ID: TCMC2681
Formula: C17H26O10

Ingredient ID: TCMC2646
Formula: C18H14O6

Ingredient ID: TCMC2448
Formula: C18H12O4

Properties

Ingredient ID Formulae Name MW AlogP MlogP XlogP # HBA # HBD PSA # Rotatable Bond # Ring # Heacy Atom Lipinski RO5 Violation
TCMC801 C29H50O Beta-Sitosterol 414.39 1.3 4.54 11.595 1 1 20.23 13 4 30 1
TCMC897 C16H18O9 Chlorogenic Acid 354.1 -2.1962 2.23 -0.447 7 6 164.75 11 2 25 1
TCMC2448 C18H12O4 Pinnatin 292.07 -0.7095 3 4.284 1 0 48.67 3 4 22 0
TCMC2646 C18H14O6 Demethoxykanugin 326.08 -1.25 2.78 3.291 2 0 63.22 5 4 24 0
TCMC2681 C17H26O10 Loganin 390.15 -2.9288 2.23 -1.092 10 5 155.14 12 3 27 0
TCMC3384 C22H24N2O4 Vomicine 381.1814323 -3.0334 3.22 -0.708 4 2 71.28 0 5 28 0
TCMC3563 C14H20O7 Rhodioloside,Salidroside 300.120903 -2.4003 2.23 0.063 6 5 119.61 5 2 21 0
TCMC3752 C22H24N2O3 Β-Colubrine 365.1865177 -2.293 3.33 0.917 3 1 43.21 1 7 27 0
TCMC3823 C17H26O9 Deoxyloganin 374.1576824 -2.5043 2.34 0.768 9 4 131.67 4 3 26 0
TCMC4078 C40H40N4O2 5',6'-Dehydroguiaflavine 608.3151265 -3.3837 5.2 6.339 3 1 41.59 3 11 46 1
TCMC4129 C20H24N2O2 Akagerine 325.191603 -1.2589 3.22 2.79 3 2 46.67 2 4 24 0
TCMC4245 C23H26N2O5 Pseudobrucine 411.191997 -2.7347 3.22 -0.105 4 2 72.67 2 7 30 0
TCMC4251 C22H24N2O3 Icajine 365.1865177 -2.5731 3.33 0.466 4 1 51.05 0 5 27 0
TCMC5295 C27H34N2O9 Palicoside 530.2264307 -4.4733 3.22 1.515 10 6 165.73 6 5 38 1
TCMC5472 C27H31N2O9 3,4,5,6-Tetradehydropalicoside 526.1951305 -4.8833 3.22 2.095 10 5 165.17 6 5 38 0
TCMC5489 C28H33N2O9 3,4,5,6-Tetradehydrodolichantoside 541.2186056 -4.141 3.33 2.416 10 5 151.34 7 5 39 0
TCMC5555 C21H26N2O2 17-O-Methylakagerine 339.2072531 -0.8504 3.33 3.309 3 1 35.67 3 4 25 0
TCMC5567 C21H22N2O2 Isostrychnine 335.175953 -2.0153 3.33 1.082 3 2 44.98 1 6 25 0
TCMC5676 C19H22N2O Normacusine B 295.1810384 -1.7129 3.22 2.28 2 3 40.46 1 3 22 0
TCMC5677 C18H26O11 3'-O-Acetylloganic Acid 417.1396866 -3.6338 2.23 -1.334 11 4 171.8 5 3 29 1
TCMC5689 C18H26O11 4'-O-Acetylloganic Acid 417.1396866 -3.6338 2.23 -1.334 11 4 171.8 5 3 29 1
TCMC5775 C18H26O11 6'-O-Acetylloganic Acid 417.1396866 -3.6338 2.23 -0.905 11 4 171.8 5 3 29 1
TCMC5843 C19H28O11 Cuchiloside 432.1631617 -3.6365 2.34 -1.231 10 7 178.53 7 3 30 1
TCMC5884 C22H24N2O3 Α-Colubrine 365.1865177 -2.293 3.33 0.917 3 1 43.21 1 7 27 0
TCMC5930 C17H24O10 Dehydrologanin 388.136947 -3.0831 2.23 -1.308 10 4 148.74 4 3 27 0
TCMC5943 C24H28N2O5 Novacine 425.207647 -2.6767 3.33 -0.633 4 1 69.51 2 5 31 0
TCMC6363 C23H26N2O5 Brucine N-Oxide 410.1841719 -1.2928 3.22 -0.049 3 0 71.06 2 7 30 0
TCMC6399 C27H33N2O9 3,4-Dehydropalicoside 528.2107806 -5.4447 3.22 1.4 10 5 164.3 6 5 38 0
TCMC6408 C20H25N2O C-Alkaloid O 309.1966884 -1.3029 3.33 2.391 1 1 25.02 1 3 23 0
TCMC6412 C21H22N2O3 Strychnine N-Oxide 350.1630426 -1.1892 3.22 1.05 3 0 52.6 0 7 26 0
TCMC6539 C21H22N2O3 4-Hydroxystrychnine 351.1708676 -2.7015 3.22 0.398 3 2 54.21 0 7 26 0
TCMC6540 C22H24N2O4 2-Hydroxy-3-Methoxystrychnine 381.1814323 -2.7533 3.22 -0.046 3 2 63.44 1 7 28 0
TCMC6541 C22H24N2O4 4-Hydroxy-3-Methoxystrychnine 381.1814323 -2.7533 3.22 -0.046 3 2 63.44 1 7 28 0
TCMC6551 C21H22N2O3 Pseudostrychnine 351.1708676 -2.6311 3.22 0.994 4 2 54.21 0 7 26 0
TCMC7078 C18H26O11 7-O-Acetylloganic Acid 417.1396866 -3.6338 2.23 -0.476 11 4 171.8 5 3 29 1
TCMC7268 C22H24N2O4 16-Hydroxy-Α-Colubrine 381.1814323 -2.6829 3.22 0.339 4 2 63.44 1 7 28 0
TCMC7269 C22H24N2O4 16-Hydroxy-Β-Colubrine 381.1814323 -2.6829 3.22 0.339 4 2 63.44 1 7 28 0

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1. General Information of the Component  
2. TCM Prescriptions with the Component  
3. Putative Targets  
4. Activity & References for Filtering Putative Targets  
5. Ingredient Data & Chemical Structure Information (Properties, InChI, InChIkey, SMILES, etc.)