TCM Prescription: Tian Meng Oral Liquid



Prescription Description
Prescription IDTCMF5590
Pinyin NameTian Meng Kou Fu Ye
Chinese Name甜梦口服液
English NameTian Meng Oral Liquid
Function Description眩晕, 耳鸣, 不寐, 健忘, 脱发症
IndicationsTinnitus disorder, Vertigo disorder, Forgetfulness disorder, Insomnia disorder, Insomnia, Tinnitus, Alopecia, Dizziness
Disease ICD-11 Category SC75 [Tinnitus disorder (TM1), 耳鸣 (TM1) ];
SD22 [Vertigo disorder (TM1), 眩晕 (TM1) ];
SD23 [Forgetfulness disorder (TM1), 健忘 (TM1) ];
SD84 [Insomnia disorder (TM1), 不寐 (TM1) ];
7A0Z [Insomnia disorders, unspecified, 失眠障碍，未特指的 ];
MC41 [Tinnitus, 耳鸣 ];
ED70 [Alopecia or hair loss, 脱发 ];
MB48 [Dizziness and giddiness, 头晕和眩晕 ];
Human Tissues Associated with IndicationBrain, Heart
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH327 Eleutherococcus senticosus 刺五加 TCMH327 KR080437
TCMH197 Bombyx mori 蚕蛾 TCMH197 AGIRI001-17
TCMH967 Polygonatum sibiricum 黄精 TCMH967 ITSAH4762-14
TCMH426 Codonopsis pilosula 党参 TCMH426 ITSAL4530-14
TCMH1794 Morus alba 桑葚 TCMH1794 ITSAL1073-14
TCMH1803 Amomum villosum 砂仁 TCMH1803 ITSAD521-14
TCMH981 Astragalus membranaceus 黄芪 TCMH981 ITSAK2981-14
TCMH1848 Crataegus pinnatifida 山楂 TCMH1848 ITSAH1684-14
TCMH1186 Lycium chinense 枸杞子 TCMH1186 ITSAO4545-14
TCMH2507 Epimedium brevicornum 淫羊藿 TCMH2507 AY362429
TCMH1966 Rehmannia glutinosa 熟地黄 TCMH1966 ITSAH4578-14
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH243 Pericarpium citri reticulatae 陈皮 TCMH243
TCMH552 Rhizoma pinelliae preparata 法半夏 TCMH552
TCMH1405 Strychnos nux-vomica 马钱子 TCMH1405 PPBI045-16
TCMH1845 Dioscorea batatas 山药 TCMH1845
TCMH2581 Alisma orientale 泽泻 TCMH2581 KC573871
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT118 MGAM Maltase-glucoamylase Hydrolase O43451
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT18 GAA Lysosomal alpha-glucosidase Hydrolase P10253
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT241 CHRNA7 Neuronal acetylcholine receptor protein alpha-7 subunit Ion channel P36544
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT290 CHRM5 Muscarinic acetylcholine receptor M5 GPCR P08912
TCMT291 CHRM3 Muscarinic acetylcholine receptor M3 GPCR P20309
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT552 CHRNA3 Neuronal acetylcholine receptor subunit alpha-3 Ion channel P32297
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT605 EDNRA Endothelin receptor ET-A GPCR P25101
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT807 SLC22A12 Solute carrier family 22 member 12 Transporter Q96S37
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CA12, CA2, CA7, CHRM1, CHRM3, CHRNA3, CHRNA7, CYP19A1, CYP1A1, CYP1B1, EDNRA, FABP3, FABP4, FLT3, GAA, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HCAR2, HSD17B1, HSD17B2, KDR, MET, PPARA, SLC1A1, SRC, XDH 8.06534
[BP] GO:0007193 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, GRM1, GRM3, GRM5, GRM8 8.06534
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, AXL, BCL2, CA9, CHRNA3, CHRNA7, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, GRIK5, GRM5, HSD17B2, IGF1R, MMP2, MMP9, PPARA, RORC, SRC, TYR 7.87352
[BP] GO:0095500 None CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, CHRNA7 6.97605
[BP] GO:1903831 None CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, CHRNA7 6.97605
[BP] GO:0007215 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 6.97605
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.97605
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CA2, CA9, CHRNA3, CHRNA7, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD17B2, IGF1R, KDR, MMP2, PPARA, RORC, SRC, TYR 6.79531
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 6.60051
[BP] GO:0007197 None CHRM1, CHRM2, CHRM3, CHRM5 6.41326
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AXL, BCL2, CHRM1, CHRM3, CHRM5, CHRNA3, CHRNA7, CYP19A1, CYP1A2, CYP1B1, EDNRA, FABP4, GAA, GRM1, GRM5, GRM8, HSD17B2, IGF1R, MET, MGAM, MMP1, MMP2, MMP9, PIM1, PPARA, RORC, SRC, TYR 6.36214
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CHRNA7, CSNK2A1, CYP1B1, FLT3, GLO1, GRIK5, HCAR2, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TOP2A, XDH 6.31213
[BP] GO:0007207 None CHRM1, CHRM2, CHRM3, CHRM5 5.99491
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.96265
[BP] GO:0007188 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, GRM1, GRM3, GRM5, GRM8 5.92952
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA9, CDC25B, CHRM1, CHRM2, CHRM3, CHRNA3, CHRNA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EDNRA, FABP4, FLT3, FUT7, GAA, GLO1, HSD17B2, KDR, MET, MMP2, MMP9, PIM1, PPARA, RORC, SRC, TOP2A, TYR 5.8628
[BP] GO:0007268 None CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 5.8628
[BP] GO:0098916 None CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 5.8628
[BP] GO:0099536 None CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 5.77752
[BP] GO:0099537 None CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 5.77752
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, CA2, CA7, CHRNA3, CHRNA7, GRIK5, GRM1, GRM3, GRM5, GRM8 5.76848
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, CA2, CA7, CHRNA3, CHRNA7, GRIK5, GRM1, GRM3, GRM5, GRM8 5.76848
[BP] GO:0042221 response to chemical AKR1B1, ALPL, APEX1, AXL, BCL2, CA2, CA9, CHRNA3, CHRNA7, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD17B2, IGF1R, KDR, MMP2, MMP9, PPARA, RORC, SRC, TYR 5.75338
[BP] GO:0060078 None ADORA1, CHRNA3, CHRNA7, GRIA2, GRIA4, GRIK5, GRM5 5.55725
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, FLT3, GLO1, GRIK5, HCAR2, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SRC, TOP2A, XDH 5.49635
[BP] GO:0007187 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, GRM1, GRM3, GRM5, GRM8 5.43862
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CHRNA3, CHRNA7, CSNK2A1, CYP1A2, FABP3, FLT3, GRM5, IGF1R, MMP2, PPARA, SRC 5.32747
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 5.2455
[BP] GO:0009725 response to hormone AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CHRNA3, CHRNA7, CSNK2A1, CYP1A2, FABP3, FLT3, PPARA, SRC 5.05798
[BP] GO:0007271 None CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3 4.99824
[BP] GO:0010035 response to inorganic substance AKR1B1, APEX1, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, SRC 4.95716
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, FLT3, GLO1, GRIK5, HCAR2, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC, TOP2A, XDH 4.88051
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APEX1, AXL, BCL2, CA12, CA2, CA7, CHRNA7, EDNRA, FABP3, FABP4, FLT3, GAA, GRIK5, GRM1, GRM5, MET, SRC 4.84155
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, GAA, GLO1, PIM1, PPARA, TYR, XDH 4.69116
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, FABP3, FLT3, HSD17B2, RORC, SRC, TYR 4.64294
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, BCL2, CDC25B, CHRM5, CHRNA3, CHRNA7, EDNRA, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 4.61789
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CHRM1, CHRM3, CHRNA3, CHRNA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HCAR2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SLC1A1, SRC, TOP2A, XDH 4.57897
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, BCL2, CDC25B, CHRM5, CHRNA3, CHRNA7, EDNRA, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 4.57897
[BP] GO:0060079 None ADORA1, CHRNA3, CHRNA7, GRIA2, GRIA4, GRIK5 4.49119
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.4801
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.37413
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, APEX1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CHRM1, CHRNA3, CHRNA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, FABP3, FLT3, GRIK5, GRM1, GRM5, HCAR2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SRC, TOP2A, XDH 4.33937
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CHRM1, CHRM3, CHRM5, CYP1A1, EDNRA, FLT3, MET, PIM1, SRC, TYR 4.3224
[BP] GO:0007213 None CHRM1, CHRM2, CHRM3, CHRM5 4.2543
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, MET, PPARA 4.21026
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, AXL, BCL2, CA1, CA2, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, CHRNA7, CSNK2A1, CYP1B1, EDNRA, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SRC 4.16176
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GLO1, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SRC 4.07244
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FLT3, RORC, SRC, TYR 3.87117
[BP] GO:0007154 None ADORA1, AXL, BCL2, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 3.81212
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GLO1, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SRC 3.81212
[BP] GO:0042391 None ADORA1, BCL2, CHRNA3, CHRNA7, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC 3.81212
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CHRNA7, CYP1A1, CYP1B1, KDR, SRC 3.79731
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, AXL, BCL2, CA2, CA7, CHRNA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, GRM1, HCAR2, KDR, MET, MMP9, PTPN1, SRC, XDH 3.76273
[BP] GO:0007267 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 3.76184
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, MMP2, MMP9, RORC, SRC 3.74893
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, AXL, BCL2, CA2, CA7, CHRNA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, GRM1, HCAR2, KDR, MET, MMP9, PTPN1, SRC, XDH 3.74893
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, AXL, BCL2, CA2, CHRM1, CHRM2, CHRM3, CHRNA3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EDNRA, FLT3, GAA, HSD17B2, KDR, MMP9, PIM1, PPARA, RORC, SRC, TYR 3.70563
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, SLC1A1 3.68084
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.63646
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, GRIK5, GRM1, GRM5, IGF1R, KDR, MMP2, MMP9, PTPN1, RORC, SRC, TOP2A 3.60887
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA9, CHRM2, CHRNA3, CHRNA7, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EDNRA, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HSD17B2, IGF1R, KDR, MMP2, MMP9, PPARA, PTPN1, RORC, SRC, TOP2A, TYR 3.56503
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1B1, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, MMP2, RORC, SRC 3.56503
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2 3.54743
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, GRM1, GRM3, GRM5, GRM8 3.54743
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, SRC 3.54743
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.54743
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 3.54743
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, BCL2, CYP1B1, MMP9, SRC 3.51106
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CHRNA7, CYP1A1, EDNRA, MMP2, PPARA, SRC 3.43925
[BP] GO:0006940 None ADORA1, CHRM1, CHRM2, CHRM3, CHRNA3 3.37807
[BP] GO:0023052 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 3.37765
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CHRNA3, CHRNA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, MMP9, PTPN1, SRC, XDH 3.37178
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.37178
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CHRNA7, CYP1A1, EDNRA, MMP2, PPARA, SRC 3.35945
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CHRM5, CYP1A1, FABP3, FLT3, HCAR2, PPARA, RORC, SRC 3.33623
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, AXL, BCL2, CA1, CSNK2A1, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 3.336
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, CHRNA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EDNRA, FABP3, FABP4, FLT3, FUT7, GAA, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MGAM, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SLC1A1, SRC, TOP2A, TYR, XDH 3.31764
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CHRNA3, CHRNA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, MMP9, PTPN1, SRC, XDH 3.29123
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, BCL2, CDC25B, CHRM1, CHRNA7, CSNK2A1, CYP1B1, FABP3, FLT3, IGF1R, KDR, MMP2, MMP9, PIM1, SRC, XDH 3.28675
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM5, CHRNA3, CHRNA7, FABP3, GRIA2, GRIA4, GRIK5, PPARA, SLC1A1 3.27843
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GLO1, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC 3.27131
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.24055
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, GAA, MGAM, MMP1, MMP2, MMP9, SRC, XDH 3.22521
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, BCL2, CA9, CHRNA3, CHRNA7, CYP1A1, CYP1B1, FABP3, KDR, SRC 3.19768
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5 3.19768
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.19768
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APEX1, AXL, BCL2, CA2, CA7, CHRM1, CHRNA3, CSNK2A1, CYP19A1, CYP1B1, GRIK5, GRM5, HCAR2, IGF1R, KDR, MET, MMP9, PPARA, PTPN1, SRC 3.14646
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CHRNA7, CYP1A1, EDNRA, MMP2, PPARA, SRC 3.14062
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EDNRA, FLT3, HSD17B2, KDR, PPARA, SRC, TYR 3.12544
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, GAA, HSD17B1, HSD17B2, TYR, XDH 3.08872
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CHRNA3, CYP19A1, CYP1A1, CYP1B1, HCAR2, HSD17B1, HSD17B2 3.07924
[BP] GO:0044057 None ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, CHRNA3, GAA, GRM1, HCAR2, SLC1A1 3.0111
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.85788
[BP] GO:0048878 chemical homeostasis AKR1B1, BCL2, CA12, CA2, CA7, CHRNA7, EDNRA, FABP3, FABP4, GRIK5, GRM1, GRM5, MET 2.85788
[BP] GO:0007200 None CHRM1, CHRM2, CHRM3, CHRM5, GRM5 2.85418
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, BCL2, CDC25B, CHRNA3, CHRNA7, FLT3, GRM1, GRM5, KDR, MMP9, PTPN1, SRC, XDH 2.85396
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, SLC1A1 2.8448
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, BCL2, CDC25B, CHRNA3, CHRNA7, FABP3, FLT3, GRM1, GRM5, KDR, MMP9, PTPN1, SRC, XDH 2.8448
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, BCL2, CDC25B, CHRNA3, CHRNA7, FABP3, FLT3, GRM1, GRM5, KDR, MMP9, PTPN1, SRC, XDH 2.8448
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, CHRNA3, CHRNA7, FABP3, FLT3, GRM5, IGF1R, MMP2, PPARA, SRC, TYR 2.76861
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, AXL, BCL2, CHRNA7, CYP1B1, FLT3, GRM1, KDR, MET, PTPN1, SRC, XDH 2.72397
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, BCL2, CDC25B, CHRNA3, CHRNA7, FLT3, GRM1, GRM5, KDR, MMP9, PTPN1, SRC, XDH 2.6743
[BP] GO:1901652 response to peptide AKR1B1, APEX1, CHRNA7, FABP3, GRM5, IGF1R, PPARA, SRC 2.62814
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, BCL2, CA2, CHRNA7, CYP1A1, EDNRA, GRM1, MMP2, PPARA, SRC, TYR 2.61533
[BP] GO:0042325 regulation of phosphorylation ADORA1, BCL2, CDC25B, CHRNA3, CHRNA7, FABP4, FLT3, GRM1, GRM5, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 2.58679
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, CHRNA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EDNRA, FABP3, FABP4, FLT3, GAA, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SLC1A1, SRC, TOP2A, XDH 2.58102
[BP] GO:0002521 leukocyte differentiation AXL, BCL2, FLT3, FUT7, GLO1, MMP9, RORC 2.53671
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CHRM1, CHRNA7, CSNK2A1, FLT3, IGF1R, KDR, MMP2, MMP9, PIM1 2.48633
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APEX1, BCL2, CHRM1, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, SRC 2.4601
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.45536
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, BCL2, CDC25B, CHRNA3, CHRNA7, FABP4, FLT3, GRM1, GRM5, IGF1R, KDR, MMP9, PTPN1, SRC, XDH 2.43939
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, AXL, CYP1B1, GRIK5, GRM5, IGF1R, MMP2, MMP9, RORC, SRC 2.43373
[BP] GO:0003008 None ADORA1, AKR1B1, BCL2, CHRM1, CHRM3, CHRM5, CHRNA7, CYP1B1, EDNRA, GAA, GRM1, GRM5, GRM8, SRC, TYR 2.42603
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.42603
[BP] GO:0099566 None GRM1, GRM5 2.42603
[BP] GO:0000023 None GAA, MGAM 2.42603
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.42603
[BP] GO:1905144 None CHRNA3, CHRNA7 2.42603
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, CHRNA7, FABP3, FLT3, GRM5, IGF1R, MMP2, PPARA, SRC, TYR 2.42603
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.42603
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.41508
[BP] GO:0006810 None ACHE, ADORA1, ALOX5, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM1, CHRM3, CHRM5, CHRNA3, CHRNA7, EDNRA, FABP3, GAA, GRIA2, GRIA4, GRIK5, MGAM, MMP9, PPARA, SLC1A1, SRC, XDH 2.41508
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.39409
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, SRC 2.37597
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, PPARA, RORC, SRC, TOP2A 2.36375
[BP] GO:1903522 None ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, GAA, SLC1A1 2.35633
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 2.34209
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, CHRNA3, CHRNA7, FLT3, GRM1, GRM5, PTPN1, SRC 2.33328
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.32483
[BP] GO:0045859 regulation of protein kinase activity ADORA1, CDC25B, CHRNA3, CHRNA7, FABP4, FLT3, GRM1, GRM5, IGF1R, PTPN1, SRC 2.30373
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR 2.30247
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.28995
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.28995
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, AURKB, AXL, BCL2, CHRNA7, CSNK2A1, CYP1B1, FLT3, GRM1, IGF1R, KDR, MET, MMP9, PTPN1, SRC, XDH 2.25055
[BP] GO:0043393 regulation of protein binding AURKB, BCL2, MET, MMP9, PPARA, SRC 2.22635
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.21788
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, CA2, CHRM1, CHRM2, CHRM3, CHRM5, EDNRA, GRM1, GRM3, GRM5, GRM8, HCAR2, SRC 2.21638
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, MET, PPARA 2.20563
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, KDR, SRC 2.20204
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.18595
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.17992
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, FUT7, GAA, GLO1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MGAM, MMP1, MMP2, PIM1, PPARA, PTPN1, RORC, SRC, TOP2A, TYR, XDH 2.17984
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, SRC 2.17503
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, CHRNA3, CHRNA7, FLT3, GRM1, GRM5, PTPN1, SRC 2.16344
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, CHRNA3, CHRNA7, FLT3, GRM1, GRM5, PTPN1, SRC 2.15115
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1 2.119
[BP] GO:0051234 None ACHE, ADORA1, ALOX5, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM1, CHRM3, CHRM5, CHRNA3, CHRNA7, EDNRA, FABP3, GAA, GRIA2, GRIA4, GRIK5, MGAM, MMP9, PPARA, SLC1A1, SRC, XDH 2.10234
[BP] GO:0035235 None GRIA2, GRIA4, GRIK5 2.09338
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, AXL, BCL2, CHRNA7, CSNK2A1, CYP1B1, FLT3, GRM1, KDR, MET, MMP9, PTPN1, SRC, XDH 2.08752
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CSNK2A1, CYP1B1, FABP4, GRM3, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC 2.08417
[BP] GO:1900543 None EDNRA, GRM3, GRM8, PPARA 2.08417
[BP] GO:0043549 regulation of kinase activity ADORA1, CDC25B, CHRNA3, CHRNA7, FABP4, FLT3, GRM1, GRM5, IGF1R, PTPN1, SRC 2.0803
[BP] GO:0048731 system development ACHE, ADORA1, ALPL, CHRM1, CHRM2, CHRM3, CHRNA3, EDNRA, MMP9, SRC 2.07944
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, AURKB, BCL2, CDC25B, CHRNA3, CHRNA7, CSNK2A1, EDNRA, FABP4, FLT3, GRM1, GRM3, GRM5, IGF1R, MMP9, PTPN1, SRC, XDH 2.07469
[BP] GO:1903725 regulation of phospholipid metabolic process CHRM5, FABP3, FLT3, SRC 2.07207
[BP] GO:0045980 None EDNRA, GRM3, GRM8, PPARA 2.07207
[BP] GO:0050789 regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AURKB, AXL, BCL2, CA1, CA2, CA7, CA9, CDC25B, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, CHRNA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EDNRA, FABP3, FABP4, FLT3, GAA, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SLC1A1, SRC, TOP2A, XDH 2.06719
[BP] GO:0051338 regulation of transferase activity ADORA1, AURKB, CDC25B, CHRNA3, CHRNA7, FABP4, FLT3, GRM1, GRM5, IGF1R, PTPN1, SRC 2.05558
[BP] GO:0046541 None CHRM1, CHRM3 2.01778
[CC] GO:0098590 plasma membrane region ADORA1, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, CHRNA7, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, MET, MGAM, SLC1A1, SRC 8.06534
[CC] GO:0097060 None CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, CHRNA7, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.76685
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, CHRNA7, CSNK2A1, EDNRA, FLT3, GAA, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, MGAM, MMP2, PIM1, PTPN1, SLC1A1, SRC 6.79531
[CC] GO:0044456 None ACHE, ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, CHRNA7, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SRC 6.41326
[CC] GO:0045211 None CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, CHRNA7, GRIA2, GRIA4, GRIK5, GRM3 5.99491
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, AXL, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, CHRNA7, EDNRA, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MGAM, SLC1A1, SRC 5.1191
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX5, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, CHRNA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EDNRA, FLT3, FUT7, GAA, GLO1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD17B2, IGF1R, KDR, MET, MGAM, MMP2, PIM1, PTPN1, SLC1A1, SRC, TYR 4.80754
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, AXL, CA4, CHRM1, CHRM2, CHRM3, CHRM5, EDNRA, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, SLC1A1 4.40726
[CC] GO:0014069 None ADORA1, CHRM1, CHRNA3, GRIK5, GRM1, GRM3, GRM5, SRC 4.13988
[CC] GO:0099572 None ADORA1, CHRM1, CHRNA3, GRIK5, GRM1, GRM3, GRM5, SRC 4.13988
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, EDNRA, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, SLC1A1 4.0314
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, CHRNA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EDNRA, FLT3, FUT7, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD17B2, IGF1R, KDR, MET, MGAM, PTPN1, SLC1A1, SRC, TYR 3.70563
[CC] GO:0043005 None ADORA1, CA2, CHRM1, CHRM2, CHRM3, CHRNA3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, SRC 3.54743
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 3.47326
[CC] GO:0098802 None CHRNA3, CHRNA7, GRIA2, GRIA4, GRIK5, GRM1 2.53913
[CC] GO:0120025 None ADORA1, AKR1B1, CA2, CHRM1, CHRM2, CHRM3, CHRNA3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, SRC 2.16712
[CC] GO:0043235 receptor complex CHRNA3, CHRNA7, GRIA2, GRIA4, GRIK5, GRM1, IGF1R 2.08752
[CC] GO:0030425 None CHRM1, CHRM2, CHRM3, CHRNA3, GRIA2, GRIK5, GRM1 2.01708
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.4179
[MF] GO:0030594 None CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, CHRNA7, GRIA2, GRIA4, GRIK5, GRM1, GRM5 9.23771
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 8.06534
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, CHRNA7, EDNRA, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARA, RORC 8.06534
[MF] GO:0046914 transition metal ion binding ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, GLO1, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, TYR, XDH 7.65201
[MF] GO:0015464 None CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, CHRNA7 7.47364
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, CHRNA7, EDNRA, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET 7.37037
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, CHRNA7, EDNRA, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET 7.37037
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CHRM1, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EDNRA, FLT3, FUT7, GAA, GLO1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MGAM, MMP1, MMP2, MMP9, PIM1, PTPN1, SRC, TOP2A, TYR, XDH 7.31465
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, CHRNA7, EDNRA, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARA, RORC 7.31465
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, CHRNA7, EDNRA, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARA, RORC 7.05582
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.92408
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA3, CHRNA7, EDNRA, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, KDR, MET, PPARA, RORC 6.6365
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.41326
[MF] GO:0016907 None CHRM1, CHRM2, CHRM3, CHRM5 6.41326
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, GLO1 5.42728
[MF] GO:0004629 None ADORA1, CHRM1, CHRM3, CHRM5, EDNRA 4.79458
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CHRM1, CHRM2, CHRM3, CHRNA3, CHRNA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, IGF1R, KDR, MET, PIM1, PPARA, SRC, TOP2A 4.65514
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM3, CHRNA3, CHRNA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, GLO1, HSD17B1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SLC1A1, SRC, TOP2A, TYR, XDH 4.59767
[MF] GO:0042166 None ACHE, CHRM3, CHRNA3, CHRNA7 4.15683
[MF] GO:0042562 hormone binding ACHE, CHRM3, CHRNA3, CHRNA7, HSD17B1, IGF1R 4.0314
[MF] GO:0005231 None CHRNA3, CHRNA7, GRIA2, GRIA4, GRIK5 3.88162
[MF] GO:0008081 None ADORA1, APEX1, CHRM1, CHRM3, CHRM5, EDNRA 3.87117
[MF] GO:0098960 None CHRNA3, CHRNA7, GRM1, GRM5 3.81762
[MF] GO:0022824 None CHRNA3, CHRNA7, GRIA2, GRIA4, GRIK5 3.81762
[MF] GO:0022835 None CHRNA3, CHRNA7, GRIA2, GRIA4, GRIK5 3.81762
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.70563
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.53251
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRM3, CHRNA3, CHRNA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, GLO1, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SLC1A1, TOP2A, TYR, XDH 3.4898
[MF] GO:0004435 None CHRM1, CHRM3, CHRM5, EDNRA 3.47584
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, GLO1, MMP1, MMP2, MMP9, PPARA, PTPN1, RORC 3.47326
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.47326
[MF] GO:0042578 None ADORA1, ALPL, APEX1, CDC25B, CHRM1, CHRM3, CHRM5, EDNRA, PTPN1 3.31764
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2, TYR, XDH 3.2291
[MF] GO:0005230 None CHRNA3, CHRNA7, GRIA2, GRIA4, GRIK5 3.14062
[MF] GO:0016788 None ACHE, ADORA1, ALPL, APEX1, CA1, CA2, CDC25B, CHRM1, CHRM3, CHRM5, EDNRA, PTPN1 3.1085
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 3.04517
[MF] GO:0099528 None CHRM1, CHRM2, CHRM3, CHRM5 2.97668
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 2.71835
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.71104
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 2.69331
[MF] GO:0004620 None ADORA1, CHRM1, CHRM3, CHRM5, EDNRA 2.55967
[MF] GO:0004930 None ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, CHRM5, EDNRA, GRM1, GRM3, GRM5, GRM8, HCAR2 2.54398
[MF] GO:0042165 neurotransmitter binding ACHE, CHRM3, CHRNA3, CHRNA7 2.48888
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.4556
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.42603
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.42603
[MF] GO:0032450 None GAA, MGAM 2.42603
[MF] GO:0099583 None GRM1, GRM5 2.42603
[MF] GO:0008227 None CHRM1, CHRM2, CHRM3, CHRM5 2.38415
[MF] GO:0016298 None ADORA1, CHRM1, CHRM3, CHRM5, EDNRA 2.20228
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC 2.1903
[MF] GO:0004971 None GRIA2, GRIA4 2.18595
[MF] GO:0004558 None GAA, MGAM 2.18595
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, APEX1, CSNK2A1, FLT3, IGF1R, KDR, MMP9, PIM1, PPARA, PTPN1, SRC 2.13451
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, HSD17B1, HSD17B2, XDH 2.09338
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC 2.07744
[MF] GO:0015276 None CHRNA3, CHRNA7, GRIA2, GRIA4, GRIK5 2.07207
[MF] GO:0022834 None CHRNA3, CHRNA7, GRIA2, GRIA4, GRIK5 2.07207
[MF] GO:0070405 ammonium ion binding ACHE, CHRM3, CHRNA3, CHRNA7 2.05596


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, GRIA2, CHRM3, CHRNA3, CHRM1, CHRNA7, GRIK5, CHRM5, GRM1, GRM3, GRM5, EDNRA, ADORA3, GRM8, ADORA1, GRIA4 13.4684
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.5381
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 8.0387
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, CHRM3, CHRNA3, CHRM1, CHRNA7, CHRM5, BCL2 7.1391
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, GRM1, GRIA4 7.1391
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, CHRM3, GRM5, EDNRA, CHRM1, CHRNA7, CHRM5, GRM1 5.7279
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 6.1964
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, GRIA2, EDNRA, CHRM1, ADORA1, PPARA, GRIA4 5.451
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.2982
Metabolic pathways_Homo sapiens_hsa01100 MGAM, GAA, AKR1B1, TYR, CYP19A1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH 3.5474
Pathways in cancer_Homo sapiens_hsa05200 EDNRA, FLT3, MMP1, MMP2, BCL2, MMP9, MET, IGF1R 3.4425
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, IGF1R 3.3702
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.9763
Galactose metabolism_Homo sapiens_hsa00052 MGAM, AKR1B10, GAA, AKR1B1 4.4458
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.2086
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, GRM1 2.7222
MicroRNAs in cancer_Homo sapiens_hsa05206 BCL2, PIM1, CYP1B1, MMP9, MET, CDC25B 2.6643
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, GRM1, GRIA4 2.7131
Chemical carcinogenesis_Homo sapiens_hsa05204 CHRNA7, CYP1A2, CYP1A1, CYP1B1 2.9702
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, IGF1R 2.575
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CHRM1, KDR, BCL2, MET, IGF1R 2.4035
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM3, CHRM1, SRC, CHRM5 2.4795
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, GRM8, GRM1 2.2421
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.7222
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, CHRNA7, GRIA4 2.7222
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1, IGF1R 2.3161
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, PIM1 1.7719
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, GRM1 2.2279
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.9473
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, MET, IGF1R 1.7406
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP1A2, CYP1A1, CYP1B1 2.1167
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, GRM1 1.9274
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.4791
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.6133
Hepatitis B_Homo sapiens_hsa05161 SRC, BCL2, MMP9 1.4148
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 EDNRA, ADORA3, ADORA1 1.3257
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 1.0901
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.3576
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.3529
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.3257
Prostate cancer_Homo sapiens_hsa05215 BCL2, IGF1R 1.1034
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.0933
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.9714
Taste transduction_Homo sapiens_hsa04742 CHRM3, GRM1 1.1515
Starch and sucrose metabolism_Homo sapiens_hsa00500 MGAM, GAA 1.3576
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, GRIA4 1.2842
Gastric acid secretion_Homo sapiens_hsa04971 CHRM3, CA2 1.2282
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.2537
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.0705
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.2842
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3342
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, GRIA4 1.0811
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2 1.4262
Renin secretion_Homo sapiens_hsa04924 EDNRA, ADORA1 1.2953
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2, IGF1R 1.0382
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 1.0074
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 1.0901
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.1936
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1 1.2917
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2, BCL2 1.4145
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.2806
Pancreatic secretion_Homo sapiens_hsa04972 CHRM3, CA2 1.0798
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, GRIA4 0.9031
FoxO signaling pathway_Homo sapiens_hsa04068 GRM1, IGF1R 0.8861
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2 0.9654
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1 0.787
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.9654
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8589
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.6538
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.7279
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.2557
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.3175
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.3332
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3404
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3533
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.3633
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3401
Apoptosis_Homo sapiens_hsa04210 BCL2 0.4089
Measles_Homo sapiens_hsa05162 CSNK2A1 0.4104
Platelet activation_Homo sapiens_hsa04611 SRC 0.4325
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.398
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.4089
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.3946
Lysosome_Homo sapiens_hsa04142 GAA 0.4325
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.4325
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.3825
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4426
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 IGF1R 0.4089
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.4089
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.4325
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.4148
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4325
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.4325
Vascular smooth muscle contraction_Homo sapiens_hsa04270 EDNRA 0.4325
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.4325
Serotonergic synapse_Homo sapiens_hsa04726 ALOX5 0.4399
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.4893
Axon guidance_Homo sapiens_hsa04360 MET 0.4275
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4701
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4701
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.4735
Insulin secretion_Homo sapiens_hsa04911 CHRM3 0.4893
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.4811
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4893
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4893
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4811
Small cell lung cancer_Homo sapiens_hsa05222 BCL2 0.4893
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.4893
Salivary secretion_Homo sapiens_hsa04970 CHRM3 0.4893
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4893
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4893
Peroxisome_Homo sapiens_hsa04146 XDH 0.4893
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.4893
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.5319
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6511
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5339
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5488
Glioma_Homo sapiens_hsa05214 IGF1R 0.5488
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5476
Bile secretion_Homo sapiens_hsa04976 CA2 0.533
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2 0.5349
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.5488
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.5488
Shigellosis_Homo sapiens_hsa05131 SRC 0.5488
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7392
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5 0.5488
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9566
Malaria_Homo sapiens_hsa05144 MET 0.6319
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 MGAM 0.6538
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6523
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.6934
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.7373
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7762
Base excision repair_Homo sapiens_hsa03410 APEX1 0.756
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.787
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8207
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7844
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8108
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.0709
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0311


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)