Component: Codonopsis pilosula 党参清膏


Description of the Component

Component ID
TCMH428
Latin Name
Codonopsis pilosula
English Name
Root of hairy asiabell
Chinese Pinyin Name
Dang Shen Qing Gao
中文名
党参清膏
TCM Properties
TCM Meridians
Therapeutic Class English
Therapeutic Class Chinese
Functions
Toxicity
NA
Geo-authentic habitats (道地产区)
NA
Reference
CFDA
Barcode ID
ITSAL4530-14
Barcode Source
BOLDSYSTEMS

TCM Prescriptions with the Component

Prescription ID Prescription English Name Prescription Chinese Name
TCMFx3986 Ge Jie Dang Shen Ointment 蛤蚧党参膏

Targeted Human Proteins by the Ingredient of Component

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT1 EHMT2 Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Transferase Q96KQ7
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT11 HIF1A Hypoxia-inducible factor 1 alpha Transcription factor Q16665
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT125 GBA Beta-glucocerebrosidase Hydrolase P04062
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT132 BCHE Butyrylcholinesterase Hydrolase P06276
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT143 CA3 Carbonic anhydrase III Lyase P07451
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT151 PRKCA Protein kinase C alpha Kinase P17252
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT158 EPHX2 Epoxide hydratase Lyase P34913
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT18 GAA Lysosomal alpha-glucosidase Hydrolase P10253
TCMT186 MAOB Monoamine oxidase B Oxidoreductase P27338
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT195 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 Kinase Q02750
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT22 ALPI Intestinal alkaline phosphatase Hydrolase P09923
TCMT220 CYP2J2 Cytochrome P450 2J2 Oxidoreductase P51589
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT225 CA13 Carbonic anhydrase XIII Lyase Q8N1Q1
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT248 CXCL8 Interleukin-8 Unclassified P10145
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT265 GSK3B Glycogen synthase kinase-3 beta Kinase P49841
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT273 NR1H4 Bile acid receptor FXR Nuclear receptor Q96RI1
TCMT276 SLCO2B1 Solute carrier organic anion transporter family member 2B1 Transporter O94956
TCMT277 SLCO1B3 Solute carrier organic anion transporter family member 1B3 Transporter Q9NPD5
TCMT278 SLCO1B1 Solute carrier organic anion transporter family member 1B1 Transporter Q9Y6L6
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT281 DPP4 Dipeptidyl peptidase IV Unclassified P27487
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT301 PTGES Prostaglandin E synthase Isomerase O14684
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT307 KCNH2 HERG Ion channel Q12809
TCMT31 CYP2C19 Cytochrome P450 2C19 Oxidoreductase P33261
TCMT311 SLC47A1 Multidrug and toxin extrusion protein 1 Transporter Q96FL8
TCMT320 MMP3 Matrix metalloproteinase 3 Hydrolase P08254
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT331 PLG Plasminogen Unclassified P00747
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT340 GLRA1 Glycine receptor subunit alpha-1 Ion channel P23415
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT39 PDE5A Phosphodiesterase 5A Hydrolase O76074
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT402 ALK ALK tyrosine kinase receptor Kinase Q9UM73
TCMT41 IDH1 Isocitrate dehydrogenase [NADP] cytoplasmic Oxidoreductase O75874
TCMT42 KMT2A Histone-lysine N-methyltransferase MLL Transferase Q03164
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT441 PTK2 Focal adhesion kinase 1 Kinase Q05397
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT460 MAPKAPK2 MAP kinase-activated protein kinase 2 Kinase P49137
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT507 MAPK14 MAP kinase p38 alpha Kinase Q16539
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT571 ADORA2B Adenosine A2b receptor GPCR P29275
TCMT588 DAO D-amino-acid oxidase Oxidoreductase P14920
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT598 TOP1 DNA topoisomerase I Isomerase P11387
TCMT6 NFKB1 Nuclear factor NF-kappa-B p105 subunit Transcription factor P19838
TCMT601 F2 Thrombin Unclassified P00734
TCMT620 HSPA8 Heat shock cognate 71 kDa protein Unclassified P11142
TCMT624 HSP90AB1 Heat shock protein HSP 90-beta Unclassified P08238
TCMT629 ABCC1 Multidrug resistance-associated protein 1 Transporter P33527
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT632 PNP Purine nucleoside phosphorylase Transferase P00491
TCMT64 PPARD Peroxisome proliferator-activated receptor delta Nuclear receptor Q03181
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT67 PPARG Peroxisome proliferator-activated receptor gamma Nuclear receptor P37231
TCMT683 MIF Macrophage migration inhibitory factor Isomerase P14174
TCMT69 THRB Thyroid hormone receptor beta-1 Nuclear receptor P10828
TCMT704 ERBB2 Receptor protein-tyrosine kinase erbB-2 Kinase P04626
TCMT707 ADORA2A Adenosine A2a receptor GPCR P29274
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT747 ABCG2 ATP-binding cassette sub-family G member 2 Transporter Q9UNQ0
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT80 MAPK1 MAP kinase ERK2 Kinase P28482
TCMT81 ALOX12 Arachidonate 12-lipoxygenase Oxidoreductase P18054
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT827 NQO1 Quinone reductase 1) Oxidoreductase P15559
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT95 MPG DNA-3-methyladenine glycosylase Hydrolase P29372


Targeted Pathogenic Microbes by the Ingredient of Component

Target ID Target Name
TCMT1088 Carbonic anhydrase
TCMT1090 Human immunodeficiency virus type 1 integrase
TCMT1092 Fatty acid synthase
TCMT1093 Enoyl-acyl-carrier protein reductase
TCMT1094 3-oxoacyl-acyl-carrier protein reductase
TCMT1099 Neuraminidase
TCMT1108 Integrase
TCMT1109 Reverse transcriptase
TCMT1121 Sialidase
TCMT1136 Neuraminidase
TCMT1178 Actinomyces viscosus
TCMT1208 Escherichia coli K12
TCMT1212 Verticillium dahliae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1246 Escherichia coli
TCMT1251 Candida albicans
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1465 Entamoeba histolytica

Ingredient Structrues

Ingredient ID: TCMC923
Formula: C6H8O7

Ingredient ID: TCMC801
Formula: C29H50O

Ingredient ID: TCMC798
Formula: C10H8O

Ingredient ID: TCMC737
Formula: C21H20O11

Ingredient ID: TCMC673
Formula: C29H50O2

Ingredient ID: TCMC632
Formula: C10H13N5O4

Ingredient ID: TCMC553
Formula: C6H6O3

Ingredient ID: TCMC548
Formula: C28H34O15

Ingredient ID: TCMC526
Formula: C21H20O11

Ingredient ID: TCMC34
Formula: C10H14N2

Ingredient ID: TCMC2560
Formula: C9H20O

Ingredient ID: TCMC2491
Formula: C3H6O2

Ingredient ID: TCMC2324
Formula: C10H16

Ingredient ID: TCMC2232
Formula: C29H50O2

Ingredient ID: TCMC2201
Formula: C8H10O2

Ingredient ID: TCMC2131
Formula: C4H6O6

Ingredient ID: TCMC2129
Formula: C30H50O

Ingredient ID: TCMC2114
Formula: C6H11NOS2

Ingredient ID: TCMC1982
Formula: C15H10O7

Ingredient ID: TCMC1871
Formula: C6H6O

Ingredient ID: TCMC1839
Formula: C7H6O3

Ingredient ID: TCMC1741
Formula: C6H5NO2

Ingredient ID: TCMC1609
Formula: C15H10O8

Ingredient ID: TCMC16
Formula: C18H20O3

Ingredient ID: TCMC1512
Formula: C9H11NO2

Ingredient ID: TCMC1446
Formula: C21H20O11

Ingredient ID: TCMC1429
Formula: C15H10O6

Ingredient ID: TCMC1409
Formula: C21H20O12

Ingredient ID: TCMC1402
Formula: C21H20O13

Ingredient ID: TCMC1356
Formula: C21H20O12

Ingredient ID: TCMC1331
Formula: C6H9N3O2

Ingredient ID: TCMC1321
Formula: C28H34O15

Ingredient ID: TCMC1271
Formula: C2H5NO2

Ingredient ID: TCMC1203
Formula: C8H8O5

Ingredient ID: TCMC1202
Formula: C7H6O5

Ingredient ID: TCMC1101
Formula: C11H12O3

Properties

Ingredient ID Formulae Name MW AlogP MlogP XlogP # HBA # HBD PSA # Rotatable Bond # Ring # Heacy Atom Lipinski RO5 Violation
TCMC16 C18H20O3 (-)-Larreatricin 284.14 -0.9087 3.11 3.818 1 2 49.69 6 3 21 0
TCMC34 C10H14N2 (+/-)Nicotine 162.12 -0.4993 2.34 1.485 2 0 16.13 2 2 12 0
TCMC526 C21H20O11 5,7-Dihydroxy-2-(4-Hydroxyphenyl)-3-[(2R,3S,4R,5R,6S)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Oxan-2-Yl]Oxychromen-4-One 448.1 -4.4318 2.56 0.18 7 7 186.37 11 4 32 1
TCMC548 C28H34O15 5-Hydroxy-2-(3-Hydroxy-4-Methoxyphenyl)-7-[3,4,5-Trihydroxy-6-[(3,4,5-Trihydroxy-6-Methyloxan-2-Yl)Oxymethyl]Oxan-2-Yl]Oxy-2,3-Dihydrochromen-4-One 610.19 -4.86 2.89 -1.489 10 8 234.29 17 5 43 1
TCMC553 C6H6O3 5-Hydroxymethyl-Furfural 126.03 -0.7952 1.79 0.422 2 1 50.44 3 1 9 0
TCMC632 C10H13N5O4 Adenosine 267.1 -2.2791 1.57 -1.809 9 4 139.54 6 3 19 0
TCMC673 C29H50O2 Alpha-Tochopherol 430.38 3.2935 4.43 10.938 0 1 29.46 21 2 31 2
TCMC737 C21H20O11 Astragalin 448.1 -4.4318 2.56 0.18 7 7 186.37 11 4 32 1
TCMC798 C10H8O Betanaphthol 144.06 -0.4603 2.45 3.92 0 1 20.23 1 2 11 0
TCMC801 C29H50O Beta-Sitosterol 414.39 1.3 4.54 11.595 1 1 20.23 13 4 30 1
TCMC923 C6H8O7 Citric Acid 192.03 -1.395 1.35 -2.247 7 4 132.13 9 0 13 0
TCMC1101 C11H12O3 Elemicin 192.08 0.6742 2.34 2.486 0 0 27.69 4 2 14 0
TCMC1202 C7H6O5 Gallic Acid 170.02 -1.6207 1.68 0.002 2 4 97.99 5 1 12 0
TCMC1203 C8H8O5 Gallic Acid Methyl Ester 184.04 -1.3697 1.79 0.323 2 3 86.99 6 1 13 0
TCMC1271 C2H5NO2 Glycine 75.03 -1.1915 1.35 -3.35 3 2 63.32 3 0 5 0
TCMC1321 C28H34O15 Hesperidin 610.19 -4.86 2.89 -1.489 10 8 234.29 17 5 43 1
TCMC1331 C6H9N3O2 Histidine 155.07 -1.3116 1.57 -3.134 5 3 92 5 1 11 0
TCMC1356 C21H20O12 Hyperoside 464.1 -4.8921 2.45 -0.354 7 8 206.6 12 4 33 1
TCMC1402 C21H20O13 Isomyricitrin 480.09 -5.3524 2.34 -0.888 7 9 226.83 13 4 34 1
TCMC1409 C21H20O12 Isoquercetin 464.1 -4.8921 2.45 -0.354 7 8 206.6 12 4 33 1
TCMC1429 C15H10O6 Kaempferol 286.05 -2.3409 2.45 1.915 2 4 107.22 5 3 21 0
TCMC1446 C21H20O11 Kuromanin 450.12 -4.0484 2.56 -0.795 6 9 180.3 12 4 32 1
TCMC1512 C9H11NO2 L-Phenylalanine 165.08 -1.0844 2.12 0.441 3 2 63.32 5 1 12 0
TCMC1609 C15H10O8 Myricetin 318.04 -3.2615 2.23 0.847 2 6 147.68 7 3 23 1
TCMC1741 C6H5NO2 Niacin 123.03 -0.2398 1.79 0.637 3 1 50.19 2 1 9 0
TCMC1839 C7H6O3 Paraben 138.03 -0.7001 1.9 1.07 2 2 57.53 3 1 10 0
TCMC1871 C6H6O Phenol 94.04 -0.4603 2.01 2.044 0 1 20.23 1 1 7 0
TCMC1982 C15H10O7 Quercetin 302.04 -2.8012 2.34 1.381 2 5 127.45 6 3 22 0
TCMC2114 C6H11NOS2 Sulforaphane 177.03 -0.9316 1.68 1.175 2 0 80.73 6 0 10 0
TCMC2129 C30H50O Taraxerol 426.39 3.4636 4.65 11.352 1 1 20.23 9 5 31 1
TCMC2131 C4H6O6 Tartrate 150.02 -1.7144 1.24 -2.238 6 4 115.06 7 0 10 0
TCMC2201 C8H10O2 Tyrosol 138.07 -0.6534 2.12 1.171 1 2 40.46 4 1 10 0
TCMC2232 C29H50O2 Vitamin E 430.38 3.2935 4.43 10.938 0 1 29.46 21 2 31 2
TCMC2324 C10H16 Limonene 136.13 2.1424 2.56 3.729 0 0 0 3 1 10 0
TCMC2491 C3H6O2 Propionic Acid 74.04 -0.1537 1.57 0.173 2 1 37.3 3 0 5 0
TCMC2560 C9H20O Nonanol 144.15 -2.4134 2.34 3.696 1 1 20.23 9 0 10 0

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