Component: Stigma croci 西红花


Description of the Component

Component ID
TCMH2226
Latin Name
Stigma croci
English Name
Saffron
Chinese Pinyin Name
Xi Hong Hua
中文名
西红花
TCM Properties
Mild,Sweet
TCM Meridians
Liver,Heart
Therapeutic Class English
Therapeutic Class Chinese
Functions
activate blood circulation and eliminate blood stasis, remove heat from blood and counteract toxicity, and calm the nerves
Toxicity
NA
Geo-authentic habitats (道地产区)
Jiangsu Province,Shanghai
Reference
Chinese Pharmacopoeia (2015)
Barcode ID
Barcode Source

TCM Prescriptions with the Component

Prescription ID Prescription English Name Prescription Chinese Name
TCMFx2918 An Kun Zan Yu Pills 安坤赞育丸
TCMFx1633 Cerebral Thrombosis Pills 益脑复健丸
TCMFx3320 Dian She Pills 点舌丸
TCMF1432 Dingkun Pills, Bolus for Woman Diseases 定坤丹
TCMF2607 Dingkun Pills, Bolus for Woman Diseases 定坤丹
TCMF3598 Feng Tong Pills 风痛丸
TCMFx7130 Fu Fang Cang Hong Hua You 复方藏红花油
TCMFx7140 Fu Fang Cang Hong Hua You 复方藏红花油
TCMFx3937 Gao Xue Ya Su Jiang Pills 高血压速降丸
TCMF4232 Hui Chun Wine 回春酒
TCMFx2096 Qishiwei Zhenzhu Pills 七十味珍珠丸
TCMFx1331 Qishiwei Zhenzhu Pills 七十味珍珠丸
TCMFx1353 Renqing Changjue Pills 仁青常觉
TCMFx2224 Renqing Changjue Pills 仁青常觉
TCMFx1290 Renqing Mangjue Pills 仁青芒觉
TCMFx1922 Renqing Mangjue Pills 仁青芒觉
TCMFx3204 Shen Gui Lu Rong Pills 参桂鹿茸丸
TCMF6962 Tong Mai Qiang Shen Wine 通脉强肾酒
TCMF7097 Xue Shan Jin Luo Han Zhi Tong Tu Mo Ji 雪山金罗汉止痛涂膜剂
TCMF6421 Yu Ye Jin Pills 玉液金丸

Targeted Human Proteins by the Ingredient of Component

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT1 EHMT2 Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Transferase Q96KQ7
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT143 CA3 Carbonic anhydrase III Lyase P07451
TCMT151 PRKCA Protein kinase C alpha Kinase P17252
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT186 MAOB Monoamine oxidase B Oxidoreductase P27338
TCMT195 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 Kinase Q02750
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT226 PDPK1 3-phosphoinositide dependent protein kinase-1 Kinase O15530
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT265 GSK3B Glycogen synthase kinase-3 beta Kinase P49841
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT355 CSNK1D Casein kinase I delta Kinase P48730
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT407 MYLK Myosin light chain kinase, smooth muscle Kinase Q15746
TCMT417 DYRK2 Dual-specificity tyrosine-phosphorylation regulated kinase 2 Kinase Q92630
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT460 MAPKAPK2 MAP kinase-activated protein kinase 2 Kinase P49137
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT466 MAPK9 c-Jun N-terminal kinase 2 Kinase P45984
TCMT473 PIM3 Serine/threonine-protein kinase PIM3 Kinase Q86V86
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT507 MAPK14 MAP kinase p38 alpha Kinase Q16539
TCMT6 NFKB1 Nuclear factor NF-kappa-B p105 subunit Transcription factor P19838
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT751 DYRK1A Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kinase Q13627
TCMT763 DYRK3 Dual-specificity tyrosine-phosphorylation regulated kinase 3 Kinase O43781
TCMT781 CYP2E1 Cytochrome P450 2E1 Oxidoreductase P05181
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT80 MAPK1 MAP kinase ERK2 Kinase P28482


Targeted Pathogenic Microbes by the Ingredient of Component

Target ID Target Name
TCMT1088 Carbonic anhydrase
TCMT1170 Enterobacter cloacae
TCMT1212 Verticillium dahliae
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1246 Escherichia coli
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1454 Bacillus subtilis

Ingredient Structrues

Ingredient ID: TCMC791
Formula: C40H56

Ingredient ID: TCMC2201
Formula: C8H10O2

Ingredient ID: TCMC1839
Formula: C7H6O3

Ingredient ID: TCMC1742
Formula: C6H6N2O

Ingredient ID: TCMC1582
Formula: C8H8O3

Ingredient ID: TCMC1567
Formula: C8H8O4

Ingredient ID: TCMC1308
Formula: C12H10N2

Properties

Ingredient ID Formulae Name MW AlogP MlogP XlogP # HBA # HBD PSA # Rotatable Bond # Ring # Heacy Atom Lipinski RO5 Violation
TCMC791 C40H56 Beta Carotene 536.44 8.935 5.86 14.734 0 0 0 20 2 40 1
TCMC1308 C12H10N2 Harman 182.08 0.0191 2.56 2.968 2 1 28.68 1 3 14 0
TCMC1567 C8H8O4 Methyl Protocatechuate 168.04 -0.9094 1.9 0.857 2 2 66.76 5 1 12 0
TCMC1582 C8H8O3 Methylparaben 152.05 -0.4491 2.01 1.391 2 1 46.53 4 1 11 0
TCMC1742 C6H6N2O Niacinamide 122.05 -0.0816 1.79 1.043 3 2 56.97 2 1 9 0
TCMC1839 C7H6O3 Paraben 138.03 -0.7001 1.9 1.07 2 2 57.53 3 1 10 0
TCMC2201 C8H10O2 Tyrosol 138.07 -0.6534 2.12 1.171 1 2 40.46 4 1 10 0

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1. General Information of the Component  
2. TCM Prescriptions with the Component  
3. Putative Targets  
4. Activity & References for Filtering Putative Targets  
5. Ingredient Data & Chemical Structure Information (Properties, InChI, InChIkey, SMILES, etc.)