TCM Prescription: Xue Shan Jin Luo Han Zhi Tong Tu Mo Ji



Prescription Description
Prescription IDTCMF7097
Pinyin NameXue Shan Jin Luo Han Zhi Tong Tu Mo Ji
Chinese Name雪山金罗汉止痛涂膜剂
English NameXue Shan Jin Luo Han Zhi Tong Tu Mo Ji
Function Description活血, 消肿, 止痛。用于急慢性扭挫伤, 风湿性关节炎, 类风湿性关节炎, 痛风, 肩周炎, 骨质增生所致的肢体关节疼痛肿胀, 以及神经性头痛。
IndicationsArthritis, Rheumatoid arthritis
Disease ICD-11 Category FA2Z [Inflammatory arthropathies, unspecified, 炎性关节病，未特指的 ];
FA20 [Rheumatoid arthritis, 类风湿性关节炎 ];
Human Tissues Associated with IndicationBlood, SkeletaMuscle
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH2103 Aconitum pendulum 铁棒锤 TCMH2103 GBVJ260-11
TCMH2376 Corydalis yanhusuo 延胡索 TCMH2376
TCMH2188 Trogopterus xanthipes 五灵脂 TCMH2188
TCMH2352 Saussurea involucrata 雪莲花 TCMH2352 ITSAJ4356-14
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH873 Radix et rhizoma rhodiolae 红景天 TCMH873
TCMH1673 Gentiana macrophylla 秦艽 TCMH1673 ITSAO2245-14
TCMH2073 Prunus persica 桃仁 TCMH2073 ITSAN1047-14
TCMH2226 Stigma croci 西红花 TCMH2226
TCMH183 Dryobalanops aromatica 冰片 TCMH183 GBVK4926-11
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT615 SENP8 Sentrin-specific protease 8 Protease Q96LD8
TCMT616 SENP7 Sentrin-specific protease 7 Protease Q9BQF6
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT643 ADRA1A Alpha-1a adrenergic receptor GPCR P35348
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT853 SIGMAR1 Sigma opioid receptor Unclassified Q99720
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA1A, AKR1B1, ALOX15, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F3, FLT3, HTR2A, HTR2B, HTR6, KDR, MET, MMP12, MMP9, PTPN1, SRC, XDH 9.68764
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA1A, AKR1B1, ALOX15, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F3, FLT3, HTR2A, HTR2B, HTR6, KDR, MET, MMP12, MMP9, PTPN1, SRC, XDH 9.68764
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA1A, AKR1B1, APP, CDC25B, CSNK2A1, CYP1B1, DRD2, DRD3, F3, FABP3, FLT3, HTR1A, HTR2A, HTR2B, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, SRC, XDH 8.02242
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD2, FABP3, FABP4, HSD17B1, HSD17B2, MET, PPARA 7.92177
[BP] GO:0042221 response to chemical ADRA1A, AKR1B1, ALOX15, APP, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, FABP3, FABP4, FLT3, HSD17B2, HTR2A, HTR2B, HTR5A, IGF1R, KDR, MMP2, MMP9, PPARA, SRC, TYR 7.64657
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRA1A, AKR1B1, ALOX15, APP, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, F3, FABP3, FABP4, FLT3, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR2B, HTR7, KDR, MET, PPARA, SRC, XDH 7.64657
[BP] GO:0010033 response to organic substance ADRA1A, AKR1B1, ALOX15, APP, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, FABP3, FABP4, FLT3, HSD17B2, HTR5A, IGF1R, KDR, MMP2, PPARA, SRC, TYR 7.31507
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.25091
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA1A, AKR1B1, ALOX15, APP, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, F3, FLT3, HTR2A, HTR2B, HTR6, KDR, MET, MMP12, MMP9, PTPN1, SRC, XDH 7.22437
[BP] GO:0007210 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 7.22437
[BP] GO:0098664 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 7.22437
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, HTR2B, PIM1, PPARA, TYR, XDH 7.15421
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA1A, AKR1B1, ALOX15, APP, AXL, CYP1B1, DRD2, F3, FLT3, HTR2A, HTR2B, HTR6, KDR, MET, PTPN1, SRC, XDH 7.01759
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TYR 7.01143
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, APP, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, FABP3, HSD17B2, HTR5A, IGF1R, MMP2, MMP9, PPARA, SRC, TYR 6.94126
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA1A, AKR1B1, ALOX15, APP, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, F3, FABP3, FLT3, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, XDH 6.93778
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA1A, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, AXL, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, F3, FABP4, HSD17B2, HTR1A, HTR2A, HTR2B, HTR7, IGF1R, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, SRC, TYR 6.86297
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA1A, AKR1B1, ALOX15, APP, AURKB, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, F3, FLT3, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, MMP9, PTPN1, SRC, XDH 6.81881
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, DRD1, DRD2, DRD3, HTR2A, HTR2B, KDR, SRC 6.65697
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP4, KDR, MMP9, SRC 6.56537
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA1A, AKR1B1, ALOX15, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, MMP12, MMP9, PTPN1, SRC, XDH 6.47222
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 6.38752
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA1A, AKR1B1, ALOX15, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, MMP12, MMP9, PTPN1, SRC, XDH 6.38702
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRA1A, AKR1B1, ALOX15, APP, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, F3, FABP3, FABP4, FLT3, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, XDH 6.28029
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA1A, AKR1B1, ALOX15, APP, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, F3, FABP4, FLT3, HTR2A, HTR2B, HTR6, KDR, MET, MMP12, MMP2, MMP9, PTPN1, SRC, XDH 6.22848
[BP] GO:0097756 None ADORA1, ADRA1A, HTR1A, HTR2A, HTR2B, HTR7 6.22848
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX15, APP, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, HTR1A, TYR 6.13992
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, HSD17B1, HSD17B2 6.10107
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ALOX15, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F3, HTR1A, HTR2A, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTPN1, SRC 6.08534
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, CDC25B, CSNK2A1, DRD2, DRD3, F3, FLT3, HTR1A, HTR2A, HTR2B, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1 6.08534
[BP] GO:0007187 None ADORA1, ADRA1A, DRD1, DRD2, DRD3, HTR1A, HTR5A, HTR6, HTR7 6.026
[BP] GO:0006939 None ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7 5.73273
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, ALOX15, APP, AURKB, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, F3, FABP3, FABP4, FLT3, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, IGF1R, KDR, MMP12, MMP2, MMP9, PPARA, PTPN1, SRC, TYR 5.64575
[BP] GO:0032502 developmental process ACHE, ADORA1, ADRA1A, AKR1B1, ALOX15, APP, AURKB, AXL, CA2, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, FABP4, FLT3, HSD17B2, HTR2A, HTR2B, HTR5A, KDR, MET, MMP2, MMP9, PIM1, PPARA, SIGMAR1, SRC, TYR 5.60984
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 5.4691
[BP] GO:0014070 response to organic cyclic compound APP, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, FLT3, HTR5A, SRC, TYR 5.4328
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 5.42894
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, ADRA1A, APP, CA2, CA7, DRD1, DRD2, DRD3, HTR2A 5.42281
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, ADRA1A, APP, CA2, CA7, DRD1, DRD2, DRD3, HTR2A 5.42281
[BP] GO:0042493 response to drug ADRA1A, AKR1B1, AXL, CA9, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, FABP3, HTR2A, HTR2B, KDR, SRC 5.39154
[BP] GO:0003018 None ADORA1, ADRA1A, DRD1, HTR1A, HTR2A, HTR2B, HTR7, SRC 5.39134
[BP] GO:0007188 None ADORA1, ADRA1A, DRD1, DRD2, DRD3, HTR1A, HTR5A, HTR7 5.37576
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA1A, ALOX15, APP, DRD2, FLT3, HTR2A, HTR2B, KDR, PTPN1, SRC, XDH 5.30804
[BP] GO:0042310 None ADRA1A, HTR1A, HTR2A, HTR2B, HTR7 5.28701
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 5.28701
[BP] GO:0042592 homeostatic process ADORA1, ADRA1A, AKR1B1, APP, AXL, CA12, CA2, CA7, DRD1, DRD2, DRD3, FABP3, FABP4, FLT3, HTR2A, HTR2B, MET, SRC 5.24043
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, DRD3, FABP3, PPARA 5.21128
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA1A, ALOX15, APP, CDC25B, DRD1, DRD2, DRD3, FABP3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 5.14143
[BP] GO:0050795 None ADORA1, DRD2, DRD3, HTR1A, HTR2A, HTR2B 5.13519
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, ADRA1A, CA2, CA7, DRD2 5.09926
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA1A, ALOX15, APP, CDC25B, DRD1, DRD2, DRD3, FABP3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 5.09926
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA1A, ALOX15, APP, CDC25B, DRD1, DRD2, FABP3, FLT3, HTR2A, HTR2B, KDR, MMP9, PTPN1, SRC, XDH 4.95455
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA1A, ALOX15, APP, CDC25B, DRD1, DRD2, FABP3, FLT3, HTR2A, HTR2B, KDR, MMP9, PTPN1, SRC, XDH 4.95455
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD1, DRD2, DRD3, HTR1A 4.93867
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, ADRA1A, APP, CA2, CA7, DRD1, DRD2 4.89331
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD2, FABP3, FABP4, MET, PPARA 4.89331
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, F3, FLT3, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SIGMAR1, SRC, XDH 4.83667
[BP] GO:0097746 None ADORA1, ADRA1A, DRD1, HTR1A, HTR2A, HTR2B, HTR7 4.83667
[BP] GO:0035296 None ADORA1, ADRA1A, DRD1, HTR1A, HTR2A, HTR2B, HTR7 4.83667
[BP] GO:0009719 response to endogenous stimulus ADRA1A, AKR1B1, APP, CA2, CA9, CSNK2A1, CYP1A2, DRD1, FABP3, FLT3, HTR5A, IGF1R, MMP2, PPARA, SRC 4.80207
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ADRA1A, ALOX15, APP, DRD2, HTR2A, HTR2B, KDR, PTPN1, SRC 4.75594
[BP] GO:0007193 None ADORA1, DRD2, DRD3, HTR1A, HTR5A, HTR7 4.75262
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, DRD1, DRD2, DRD3, HTR2A, HTR2B, KDR, SRC 4.73277
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ADRA1A, ALOX15, APP, DRD2, FLT3, HTR2A, HTR2B, IGF1R, KDR, PTPN1, SRC, XDH 4.73149
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ADRA1A, ALOX15, APP, DRD2, HTR2A, HTR2B, KDR, SRC 4.73043
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, CA2, CYP1A1, DRD1, DRD2, DRD3, HTR2A, HTR2B, MMP2, PPARA, SRC, TYR 4.72043
[BP] GO:0007198 None HTR1A, HTR5A, HTR7 4.71618
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, F3, FABP3, FABP4, FLT3, HSD17B1, HSD17B2, HTR1A, HTR2B, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, TYR, XDH 4.71618
[BP] GO:0018958 None AKR1B1, DRD1, DRD2, DRD3, HTR1A, TYR 4.71603
[BP] GO:0050880 None ADORA1, ADRA1A, DRD1, HTR1A, HTR2A, HTR2B, HTR7 4.70482
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA1A, ALOX15, APP, CDC25B, DRD1, DRD2, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 4.70482
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, CYP2D6, DRD2, DRD3, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC 4.70482
[BP] GO:0035150 None ADORA1, ADRA1A, DRD1, HTR1A, HTR2A, HTR2B, HTR7 4.69467
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, F3, FLT3, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SIGMAR1, SRC, XDH 4.64748
[BP] GO:0003013 None ADORA1, ADRA1A, DRD1, HTR1A, HTR2A, HTR2B, HTR7, SRC 4.64025
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APP, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F3, IGF1R, KDR, MET, MMP9, SRC 4.55672
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, SRC 4.55641
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, PPARA 4.54877
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, HSD17B1, HSD17B2, TYR, XDH 4.53899
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADRA1A, ALOX15, APP, CDC25B, DRD1, DRD2, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KDR, MMP9, PTPN1, SRC, XDH 4.51731
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, DRD2, HSD17B1, HSD17B2, HTR1A, HTR2A 4.50654
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APP, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, MET, MMP9, SRC 4.44077
[BP] GO:0048583 regulation of response to stimulus ADORA1, ADRA1A, AKR1B1, ALOX15, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F3, FABP4, FLT3, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, MMP12, MMP2, MMP9, PPARA, PTPN1, SRC, XDH 4.36701
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3 4.36253
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 4.29382
[BP] GO:0048148 None DRD1, DRD2, DRD3, HTR2A 4.29382
[BP] GO:0048878 chemical homeostasis ADRA1A, AKR1B1, APP, CA12, CA2, CA7, DRD1, DRD2, DRD3, FABP3, FABP4, HTR2A, HTR2B, MET 4.29157
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA1A, ALOX15, APP, CDC25B, DRD2, FLT3, HTR2A, HTR2B, KDR, MMP9, PTPN1, SRC, XDH 4.2855
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SRC 4.26355
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, DRD3, FABP3, PPARA 4.25086
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, ADRA1A, APP, CA2, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, SIGMAR1, SRC 4.19809
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 4.16735
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APP, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, MET, MMP9, SRC 4.16735
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ALOX15, APP, AXL, CA2, CA7, CYP19A1, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, MMP12, MMP9, PPARA, PTPN1, SRC 4.14124
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA1A, ALOX15, APP, CDC25B, DRD2, FLT3, HTR2A, HTR2B, KDR, MMP9, PTPN1, SRC, XDH 4.07931
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, F3, FLT3, HTR2B, IGF1R, KDR, MMP9, PIM1, PTPN1, SIGMAR1, SRC, XDH 4.0436
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, ADRA1A, AKR1B1, ALOX15, APP, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, FLT3, HSD17B2, HTR5A, KDR, MMP9, PIM1, PPARA, SIGMAR1, SRC, TYR 4.02231
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 4.0018
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.99282
[BP] GO:0033993 response to lipid AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, FABP3, FLT3, HSD17B2, HTR5A, SRC, TYR 3.9533
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SRC 3.92723
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, DRD3, FABP3, FLT3, HTR2A, HTR2B, PPARA, SRC 3.90037
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRA1A, AKR1B1, APP, AXL, CA1, CA2, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MMP2, MMP9, PIM1, PPARA, PTPN1, SIGMAR1, SRC 3.88219
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.84995
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APP, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, MET, MMP9, SRC 3.81115
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, DRD1, DRD2, HTR2A, MET 3.79924
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, DRD1, DRD2, HTR2A 3.79924
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRA1A, AKR1B1, ALOX15, APP, AURKB, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, F3, FLT3, HTR2A, HTR2B, HTR6, IGF1R, KDR, MET, MMP12, MMP9, PTPN1, SRC, XDH 3.77872
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, DRD1, DRD2, DRD3, FABP3, FLT3, IGF1R, MMP2, PPARA, SRC, TYR 3.74621
[BP] GO:0051940 None DRD1, DRD2, DRD3 3.74621
[BP] GO:0051584 None DRD1, DRD2, DRD3 3.74621
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, ADRA1A, APP, AURKB, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, F3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC, XDH 3.71726
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, HTR2A, HTR2B, PPARA, SRC 3.71603
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.7148
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, CDC25B, CSNK2A1, DRD1, FLT3, HTR2B, IGF1R, KDR, MET, PIM1, SRC 3.61928
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, FABP4, MMP1, MMP12, MMP2, MMP9, SRC, XDH 3.61218
[BP] GO:0001659 None ADORA1, DRD1, DRD2, HTR2A 3.60983
[BP] GO:0071073 None FABP3, HTR2A, HTR2B 3.59905
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA1A, ALOX15, APP, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, F3, FLT3, HTR2A, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTPN1, SRC, XDH 3.59905
[BP] GO:0009636 response to toxic substance AKR1B1, AXL, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, KDR, SRC 3.59905
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, FABP3, FABP4, FLT3, HSD17B1, HSD17B2, HTR1A, HTR2B, IGF1R, KDR, MET, MMP1, MMP2, PIM1, PPARA, PTPN1, SRC, TYR, XDH 3.59186
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, SRC 3.59186
[BP] GO:0009725 response to hormone ADRA1A, AKR1B1, CA2, CA9, CSNK2A1, CYP1A2, FABP3, FLT3, HTR5A, PPARA, SRC 3.55187
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, DRD3, F3, MET, SRC, XDH 3.53198
[BP] GO:0006811 None ADRA1A, CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD1, DRD2, DRD3, FABP3, HTR2A, HTR2B, PPARA 3.5032
[BP] GO:0050801 ion homeostasis ADRA1A, APP, CA12, CA2, CA7, DRD1, DRD2, DRD3, FABP3, HTR2A, HTR2B 3.50204
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRA1A, APP, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, F3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, MMP9, PTPN1, SRC, XDH 3.4966
[BP] GO:0051952 None ADORA1, DRD1, DRD2, DRD3, HTR2A 3.49609
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.4788
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, DRD1, DRD2, DRD3, FABP3, FLT3, IGF1R, MMP2, PPARA, SRC, TYR 3.46786
[BP] GO:0030534 None APP, DRD1, DRD2, DRD3, HTR2A, PPARA 3.44758
[BP] GO:0021885 forebrain cell migration AXL, DRD1, DRD2, HTR6 3.44004
[BP] GO:0010038 response to metal ion ALOX15, APP, CA2, CYP1A1, CYP1A2, DRD2, FABP4, MMP9 3.41026
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, FABP3, FABP4, HTR2A, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTPN1, SRC, XDH 3.38715
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA1A, ALOX15, APP, AURKB, CDC25B, DRD1, DRD2, DRD3, F3, FABP3, FLT3, HTR2A, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTPN1, SRC, XDH 3.36711
[BP] GO:0002031 None DRD2, DRD3, HTR2B 3.36711
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA1A, ALOX15, APP, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, F3, FABP3, FLT3, HTR2A, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTPN1, SRC, XDH 3.36711
[BP] GO:0032467 None AURKB, CDC25B, DRD2, DRD3 3.36281
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA1A, APP, AXL, CA2, CYP1B1, DRD2, DRD3, F3, HTR2A, HTR2B, KDR, MET, MMP12, MMP9, PIM1, SRC 3.36281
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA1A, ALOX15, APP, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, F3, FLT3, HTR2A, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTPN1, SRC, XDH 3.33927
[BP] GO:0051781 None AURKB, CDC25B, DRD2, DRD3, HTR2B 3.32093
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, HTR2B, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC 3.32093
[BP] GO:0048513 animal organ development ACHE, ADRA1A, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, FLT3, HSD17B2, KDR, PPARA, SRC, TYR 3.30635
[BP] GO:0019932 second-messenger-mediated signaling ADRA1A, DRD1, DRD2, DRD3, HTR2B, HTR5A, KDR 3.28505
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, APP, AURKB, AXL, CDC25B, CSNK2A1, DRD1, DRD2, FLT3, HTR2B, IGF1R, KDR, MET, PIM1, PTPN1, SRC, XDH 3.2829
[BP] GO:0007200 None ADRA1A, DRD1, DRD2, HTR2A, HTR2B 3.2588
[BP] GO:0031399 regulation of protein modification process ADORA1, ADRA1A, ALOX15, APP, CDC25B, DRD1, DRD2, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KDR, MMP9, PTPN1, SRC, XDH 3.24347
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ADRA1A, ALOX15, APP, CDC25B, DRD2, FLT3, HTR2A, HTR2B, KDR, MMP9, PTPN1, SRC, XDH 3.2325
[BP] GO:2001023 None DRD1, DRD2, DRD3, HTR2A, MET 3.22144
[BP] GO:0019933 None ADRA1A, DRD1, DRD2, DRD3, HTR5A 3.1783
[BP] GO:0045776 None ADORA1, DRD2, DRD3, PPARA 3.1783
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 3.1783
[BP] GO:0060134 None DRD1, DRD2, DRD3 3.1783
[BP] GO:0032230 positive regulation of synaptic transmission, GABAergic ADRA1A, CA2, CA7 3.1783
[BP] GO:0006584 None AKR1B1, DRD1, DRD2, DRD3 3.14448
[BP] GO:0009712 None AKR1B1, DRD1, DRD2, DRD3 3.14448
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ADRA1A, ALOX15, APP, CDC25B, CSNK2A1, DRD2, F3, FLT3, HTR2A, HTR2B, KDR, MMP9, PTPN1, SRC, XDH 3.11182
[BP] GO:0043269 regulation of ion transport ADORA1, APP, CA2, CA7, DRD1, DRD2, DRD3, HTR1A, HTR2A, MMP9 3.10848
[BP] GO:0032787 None ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, PPARA 3.09545
[BP] GO:0051580 None DRD1, DRD2, DRD3 3.08931
[BP] GO:0051967 None ADORA1, DRD2, HTR2A 3.08931
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, ALOX15, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, FABP3, FABP4, HTR2A, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTPN1, SRC, XDH 3.06845
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, APP, AURKB, AXL, CDC25B, CSNK2A1, DRD1, DRD2, FLT3, HTR2B, IGF1R, KDR, MET, PIM1, PTPN1, SRC, XDH 3.05093
[BP] GO:0090066 None ADORA1, ADRA1A, ALOX15, DRD1, HTR1A, HTR2A, HTR2B, HTR7 3.02521
[BP] GO:0019935 None ADRA1A, DRD1, DRD2, DRD3, HTR5A 3.01098
[BP] GO:0003012 None ADORA1, ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7 3.01098
[BP] GO:0001963 None DRD1, DRD2, DRD3 3.00563
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA1A, DRD1, DRD2, DRD3, HTR2A, IGF1R, MET, MMP12, MMP9, PTPN1, SRC, XDH 2.97827
[BP] GO:0008542 None APP, DRD1, DRD2, DRD3 2.97827
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.97569
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA1A, DRD1, DRD2, DRD3, HTR2A, IGF1R, MET, MMP12, MMP9, PTPN1, SRC, XDH 2.96863
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, DRD3, F3, FABP4, KDR, MET, MMP12, PPARA 2.96718
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.96161
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, CYP1A1, DRD2, PPARA 2.94385
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, CDC25B, DRD2, FABP4, FLT3, HTR2A, HTR2B, IGF1R, PTPN1, SRC 2.94385
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, APP, AXL, CYP1A1, CYP1A2, CYP1B1, DRD1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, SRC 2.94385
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, DRD2, DRD3, HTR2B, MMP12, SRC 2.94385
[BP] GO:0098771 inorganic ion homeostasis ADRA1A, APP, CA12, CA2, CA7, DRD1, DRD2, DRD3, HTR2A, HTR2B 2.94385
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA1A, ALOX15, CYP19A1, DRD1, DRD2, DRD3, IGF1R, MET, MMP12, MMP9, PPARA, PTPN1, SRC, XDH 2.94385
[BP] GO:0071071 None FABP3, HTR2A, HTR2B 2.94385
[BP] GO:0032225 None DRD1, DRD2, DRD3 2.94385
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6 2.90343
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, APP, AXL, CA2, CYP19A1, DRD1, DRD2, DRD3, HTR2B, MMP12, SRC 2.89196
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.88753
[BP] GO:1902532 negative regulation of intracellular signal transduction ADRA1A, DRD2, DRD3, IGF1R, MET, MMP9, PTPN1, SRC, XDH 2.8858
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.87452
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, DRD2, DRD3, HTR7, PPARA, SRC 2.85
[BP] GO:0007632 None APP, DRD1, DRD2, DRD3 2.84564
[BP] GO:0006810 None ACHE, ADORA1, ADRA1A, ALOX15, ALOX5, APP, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD1, DRD2, DRD3, FABP3, HTR2A, HTR2B, MMP12, MMP9, PPARA, SIGMAR1, SRC, XDH 2.84242
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.84242
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, CDC25B, CSNK2A1, DRD1, FLT3, HTR2B, IGF1R, KDR, MET, PIM1, SRC 2.83262
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, F3, FABP3, FABP4, FLT3, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, SIGMAR1, SRC, TYR, XDH 2.83262
[BP] GO:0035556 intracellular signal transduction ADRA1A, AKR1B1, AXL, CYP1B1, DRD1, DRD2, DRD3, HTR2A, HTR2B, HTR5A, IGF1R, KDR, MET, PTPN1, SRC 2.83262
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, ALOX15, APP, AURKB, AXL, CA1, CA12, CA2, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, F3, FABP3, FABP4, FLT3, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, SIGMAR1, SRC, XDH 2.82382
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ADRA1A, ALOX15, APP, CDC25B, DRD2, F3, FLT3, HTR2A, HTR2B, KDR, MMP9, PTPN1, SRC, XDH 2.82271
[BP] GO:0014821 None DRD1, DRD2, HTR2B 2.81333
[BP] GO:0031623 None ACHE, DRD2, DRD3, HTR2B 2.79744
[BP] GO:0016477 cell migration AXL, CYP1B1, DRD1, DRD2, HTR2B, HTR6, KDR, MMP1, MMP12, MMP9, SRC 2.75953
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, CYP19A1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, MMP12, SRC 2.759
[BP] GO:0045187 None ADORA1, DRD2, DRD3 2.74661
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, APP, AURKB, AXL, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, DRD1, DRD2, DRD3, F3, FLT3, HTR1A, HTR2B, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, TYR, XDH 2.71214
[BP] GO:0043549 regulation of kinase activity ADORA1, APP, CDC25B, DRD2, FABP4, FLT3, HTR2A, HTR2B, IGF1R, PTPN1, SRC 2.70287
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, CDC25B, DRD2, FABP4, FLT3, HTR2A, HTR2B, IGF1R, PTPN1, SRC 2.70287
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, DRD1, DRD2, HTR2A 2.694
[BP] GO:0060160 None DRD2, DRD3 2.694
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.694
[BP] GO:0051234 None ACHE, ADORA1, ADRA1A, ALOX15, ALOX5, APP, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD1, DRD2, DRD3, FABP3, HTR2A, HTR2B, MMP12, MMP9, PPARA, SIGMAR1, SRC, XDH 2.694
[BP] GO:0035813 None ADORA1, DRD2, DRD3 2.694
[BP] GO:0003008 None ADORA1, ADRA1A, AKR1B1, APP, CYP1B1, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR7, SRC, TYR 2.68349
[BP] GO:0043393 regulation of protein binding APP, AURKB, MET, MMP9, PPARA, SRC 2.6813
[BP] GO:0040011 locomotion AXL, CYP1B1, DRD1, DRD2, HTR2B, HTR6, KDR, MET, MMP1, MMP12, MMP9, SRC 2.68025
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, PIM1, PPARA, TYR 2.6733
[BP] GO:0030198 extracellular matrix organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.67228
[BP] GO:0043062 extracellular structure organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.66492
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.65216
[BP] GO:0042749 None ADORA1, DRD2, DRD3 2.64279
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.64279
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6 2.64279
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, APP, AXL, CYP1A1, CYP1B1, DRD1, FABP4, FLT3, IGF1R, KDR, MMP2, SRC 2.63616
[BP] GO:0030003 cellular cation homeostasis ADRA1A, APP, CA2, CA7, DRD1, DRD2, DRD3, HTR2A, HTR2B 2.63321
[BP] GO:0006936 None ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7 2.59441
[BP] GO:0060402 None ADRA1A, DRD2, HTR2A, HTR2B 2.58071
[BP] GO:0030335 positive regulation of cell migration APP, DRD1, F3, IGF1R, KDR, MET, MMP9, SRC 2.57513
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.55836
[BP] GO:0006873 cellular ion homeostasis ADRA1A, APP, CA2, CA7, DRD1, DRD2, DRD3, HTR2A, HTR2B 2.55836
[BP] GO:0030100 regulation of endocytosis ALOX15, APP, AXL, DRD2, PTPN1, SRC 2.54616
[BP] GO:0051046 None ACHE, ADORA1, CYP19A1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, MMP12, SRC 2.53918
[BP] GO:0044062 None ADORA1, DRD2, DRD3 2.53918
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.53918
[BP] GO:0015908 None DRD2, DRD3, FABP3, PPARA 2.51453
[BP] GO:0032465 None AURKB, CDC25B, DRD2, DRD3 2.49066
[BP] GO:0007202 None ADRA1A, HTR2A, HTR2B 2.48822
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.48822
[BP] GO:2000147 positive regulation of cell motility APP, DRD1, F3, IGF1R, KDR, MET, MMP9, SRC 2.48374
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, DRD2, DRD3 2.48374
[BP] GO:0006897 endocytosis ACHE, ADORA1, ALOX15, APP, AXL, DRD2, DRD3, HTR2B 2.47922
[BP] GO:0080134 regulation of response to stress ADORA1, APP, CYP19A1, DRD2, F3, FABP4, IGF1R, MET, MMP12, MMP2, PPARA, PTPN1, SRC, XDH 2.47191
[BP] GO:0007416 None ACHE, APP, DRD1, DRD2 2.45238
[BP] GO:0048870 cell motility AXL, CYP1B1, DRD1, DRD2, HTR2B, HTR6, KDR, MMP1, MMP12, MMP9, SRC 2.45238
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.44992
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.44992
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, FLT3, HTR2A, HTR2B, IGF1R, PTPN1, SRC 2.44457
[BP] GO:0050730 None ADORA1, APP, FLT3, HTR2A, PTPN1, SRC 2.44279
[BP] GO:0008306 None APP, DRD1, DRD2, DRD3 2.4363
[BP] GO:0043271 negative regulation of ion transport ADORA1, DRD2, DRD3, HTR2A, MMP9 2.43372
[BP] GO:0051098 regulation of binding APP, AURKB, CYP2D6, MET, MMP9, PPARA, SRC 2.42636
[BP] GO:0051179 None ACHE, ADORA1, ADRA1A, ALOX15, ALOX5, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD1, DRD2, DRD3, FABP3, HTR2A, HTR2B, MMP12, MMP9, PPARA, SIGMAR1, SRC, XDH 2.42052
[BP] GO:0007189 None ADRA1A, DRD1, DRD2, DRD3 2.41949
[BP] GO:0051272 positive regulation of cellular component movement APP, DRD1, F3, IGF1R, KDR, MET, MMP9, SRC 2.41949
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRA1A, ALOX15, APP, AURKB, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, F3, FABP3, FABP4, FLT3, HTR1A, HTR2A, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTPN1, SRC, XDH 2.41429
[BP] GO:0051302 None AURKB, CDC25B, DRD2, DRD3, HTR2B 2.41328
[BP] GO:0001975 None DRD1, DRD2, DRD3 2.40933
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.40316
[BP] GO:0032845 None ADORA1, DRD2, HTR2A, HTR2B, SRC 2.40316
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, ALOX15, APP, AURKB, AXL, CA1, CA2, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, F3, FABP3, FABP4, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, SIGMAR1, SRC, XDH 2.35663
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, FABP4, MMP9 2.35224
[BP] GO:0043436 oxoacid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, PIM1, PPARA, TYR 2.35114
[BP] GO:0055080 cation homeostasis ADRA1A, APP, CA2, CA7, DRD1, DRD2, DRD3, HTR2A, HTR2B 2.3445
[BP] GO:0060401 None ADRA1A, DRD2, HTR2A, HTR2B 2.3445
[BP] GO:0008217 None ADORA1, ADRA1A, DRD2, DRD3, PPARA 2.34393
[BP] GO:0040017 positive regulation of locomotion APP, DRD1, F3, IGF1R, KDR, MET, MMP9, SRC 2.33131
[BP] GO:0042417 None DRD1, DRD2, DRD3 2.32896
[BP] GO:0014059 None DRD2, DRD3, HTR2A 2.32896
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, APP, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, PTPN1, SRC 2.31588
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, APP, AURKB, AXL, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, F3, FABP3, FABP4, FLT3, HSD17B1, HSD17B2, HTR1A, HTR2B, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, TYR, XDH 2.31588
[BP] GO:0006082 organic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, PIM1, PPARA, TYR 2.29437
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.28964
[BP] GO:0044093 positive regulation of molecular function ADORA1, ADRA1A, APP, AURKB, CDC25B, DRD2, F3, FLT3, HTR2A, HTR2B, MET, MMP9, PTPN1, SRC, XDH 2.2837
[BP] GO:0021853 None DRD1, DRD2 2.27803
[BP] GO:0010641 None F3, SRC 2.27803
[BP] GO:1904936 None DRD1, DRD2 2.27803
[BP] GO:0042321 None ADORA1, DRD2 2.27803
[BP] GO:0090325 None DRD2, DRD3 2.27803
[BP] GO:0010513 None HTR2A, HTR2B 2.27803
[BP] GO:0032963 collagen metabolic process MMP1, MMP12, MMP2, MMP9 2.2593
[BP] GO:0045787 positive regulation of cell cycle APP, AURKB, CDC25B, CYP1A1, DRD2, DRD3, SRC 2.2593
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD1, DRD2, DRD3, HTR1A 2.2593
[BP] GO:0002793 None ACHE, ADORA1, DRD2, HTR2B, MMP12, SRC 2.2593
[BP] GO:0090087 None ACHE, ADORA1, APP, CA2, DRD2, DRD3, HTR2B, MMP12, PTPN1, SRC 2.24713
[BP] GO:0055082 cellular chemical homeostasis ADRA1A, APP, CA2, CA7, DRD1, DRD2, DRD3, HTR2A, HTR2B 2.24713
[BP] GO:0008283 cell proliferation ACHE, AURKB, CYP1A1, FLT3, HTR1A, MET, PIM1, SRC, TYR 2.24336
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, DRD2, MMP2, PPARA, SRC 2.22859
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling HTR2A, HTR2B, IGF1R 2.22806
[BP] GO:0045744 None DRD2, DRD3, MET 2.22806
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AURKB, AXL, DRD2, DRD3, IGF1R, KDR, MET, MMP1, MMP9, SRC 2.22806
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ADRA1A, ALOX15, APP, CDC25B, CSNK2A1, DRD1, DRD2, F3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KDR, MMP9, PTPN1, SRC, XDH 2.22139
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, DRD2, FLT3, HTR2A, HTR2B, PTPN1, SRC 2.21397
[BP] GO:0006874 cellular calcium ion homeostasis ADRA1A, APP, DRD1, DRD2, DRD3, HTR2A, HTR2B 2.20536
[BP] GO:0098657 import into cell ACHE, ADORA1, ALOX15, APP, AXL, DRD2, DRD3, HTR2B 2.2048
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, FLT3, HTR2A, HTR2B, PTPN1, SRC 2.19546
[BP] GO:0022029 None DRD1, DRD2, HTR6 2.19546
[BP] GO:0098801 None ADORA1, DRD2, DRD3 2.19546
[BP] GO:0044259 multicellular organismal macromolecule metabolic process MMP1, MMP12, MMP2, MMP9 2.18472
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APP, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, HTR1A, MMP2, MMP9, PPARA, PTPN1, SRC 2.18129
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, DRD2, MMP2, PPARA, SRC 2.17374
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.16414
[BP] GO:0010863 positive regulation of phospholipase C activity ADRA1A, HTR2A, HTR2B 2.16112
[BP] GO:0021843 None DRD1, DRD2 2.14569
[BP] GO:0021830 None DRD1, DRD2 2.14569
[BP] GO:0021826 None DRD1, DRD2 2.14569
[BP] GO:2001300 lipoxin metabolic process ALOX15, ALOX5 2.14569
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP2D6 2.14569
[BP] GO:0055074 calcium ion homeostasis ADRA1A, APP, DRD1, DRD2, DRD3, HTR2A, HTR2B 2.14303
[BP] GO:0050890 None ADORA1, APP, DRD1, DRD2, DRD3, HTR2A 2.14303
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ADRA1A, ALOX15, APP, AURKB, CA9, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, F3, FABP3, FABP4, FLT3, HTR1A, HTR2A, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTPN1, SRC, XDH 2.13517
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, DRD2, MMP12, PPARA 2.13041
[BP] GO:0090068 positive regulation of cell cycle process APP, AURKB, CDC25B, CYP1A1, DRD2, DRD3 2.13041
[BP] GO:0051588 None DRD1, DRD2, DRD3, HTR1A 2.13024
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, DRD2, FLT3, HTR2A, HTR2B, PTPN1, SRC 2.13024
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, FABP4, MMP9 2.12242
[BP] GO:0072503 cellular divalent inorganic cation homeostasis ADRA1A, APP, DRD1, DRD2, DRD3, HTR2A, HTR2B 2.1193
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, FLT3, HTR2A, PTPN1, SRC 2.11295
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.10239
[BP] GO:0007610 None APP, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, PPARA 2.10235
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, DRD3, PPARA 2.09695
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, ADRA1A, APP, AURKB, CDC25B, DRD2, F3, FLT3, HTR2A, HTR2B, PTPN1, SRC, XDH 2.0878
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALOX15, CSNK2A1, DRD2, FABP3, FABP4, MET 2.08612
[BP] GO:1900274 regulation of phospholipase C activity ADRA1A, HTR2A, HTR2B 2.07627
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, DRD1, KDR, SRC 2.07627
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, DRD2, FLT3, HTR2A, HTR2B, PTPN1, SRC 2.06657
[BP] GO:0050789 regulation of biological process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, ALOX15, APP, AURKB, AXL, CA1, CA2, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, F3, FABP3, FABP4, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, SIGMAR1, SRC, XDH 2.05871
[BP] GO:0043112 None ACHE, DRD2, DRD3, HTR2B 2.05697
[BP] GO:0009416 response to light stimulus APP, AURKB, DRD1, DRD2, DRD3, TYR 2.05697
[BP] GO:0007212 None DRD1, DRD2, DRD3 2.04753
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CSNK2A1, CYP19A1, CYP1A1, HSD17B1, HSD17B2 2.04522
[BP] GO:0003014 None ADORA1, ADRA1A, AKR1B1, DRD2 2.04318
[BP] GO:0009820 alkaloid metabolic process CYP1A2, CYP2D6 2.03725
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2D6 2.03725
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2D6 2.03725
[BP] GO:0010511 None HTR2A, HTR2B 2.03725
[BP] GO:0014075 None DRD1, DRD2, DRD3 2.02273
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, DRD2, MMP2, PPARA, SRC 2.02014
[BP] GO:0043266 None ADORA1, DRD1, DRD2, HTR2A 2.0197
[BP] GO:0042752 None ADORA1, DRD2, DRD3, PPARA 2.0197
[BP] GO:0072507 divalent inorganic cation homeostasis ADRA1A, APP, DRD1, DRD2, DRD3, HTR2A, HTR2B 2.01862
[BP] GO:0007268 None DRD1, DRD2, DRD3, HTR2A, HTR6, HTR7 2.01753
[BP] GO:0098916 None DRD1, DRD2, DRD3, HTR2A, HTR6, HTR7 2.01753
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRA1A, APP, AXL, CA4, DRD1, DRD2, DRD3, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1 6.85277
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, ADRA1A, APP, AXL, DRD1, DRD2, DRD3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1 5.70384
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ADRA1A, ALOX15, APP, AXL, CA2, CA4, CA9, DRD1, DRD2, DRD3, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1, SRC 5.36798
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ADRA1A, ALOX15, APP, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, DRD1, DRD2, DRD3, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MMP2, PIM1, PTPN1, SRC 4.75262
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ADRA1A, ALOX15, ALOX5, APP, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, F3, FLT3, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MMP2, PIM1, PTPN1, SIGMAR1, SRC, TYR 3.71711
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ADRA1A, ALOX15, APP, AXL, CA12, CA14, CA2, CA4, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, F3, FLT3, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PTPN1, SIGMAR1, SRC, TYR 3.24195
[CC] GO:0005783 None ADORA1, APP, CA4, CYP19A1, CYP2D6, FLT3, HTR5A, KDR, PTPN1, SIGMAR1, XDH 2.37444
[CC] GO:0098590 plasma membrane region ADORA1, ADRA1A, CA2, CA4, CA9, DRD1, DRD2, HTR2A, MET, SIGMAR1, SRC 2.2593
[CC] GO:0097443 sorting endosome KDR, PTPN1 2.14569
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, TYR, XDH 10.1533
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.1533
[MF] GO:0043167 ion binding ACHE, ALOX15, ALOX5, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, F3, FABP3, FABP4, FLT3, HSD17B1, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, TYR, XDH 9.72591
[MF] GO:0070405 ammonium ion binding ACHE, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR5A, HTR7 8.7221
[MF] GO:0008227 None ADRA1A, DRD2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 7.98883
[MF] GO:0030594 None DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 7.41414
[MF] GO:0004993 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 7.22437
[MF] GO:0099589 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 7.22437
[MF] GO:0043176 None HTR1A, HTR2A, HTR2B, HTR5A, HTR7 7.15421
[MF] GO:0051378 None HTR1A, HTR2A, HTR2B, HTR5A, HTR7 7.15421
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, TYR, XDH 6.86297
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.85368
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA1A, AXL, DRD1, DRD2, DRD3, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PPARA, SIGMAR1 6.53723
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, FLT3, HTR2A, HTR2B, IGF1R, KDR, MET, PIM1, PPARA, SIGMAR1, SRC 6.47222
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRA1A, AXL, DRD1, DRD2, DRD3, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1 6.38752
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRA1A, AXL, DRD1, DRD2, DRD3, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1 6.38752
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, F3, FLT3, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PTPN1, SRC, TYR, XDH 6.2959
[MF] GO:0099528 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.28029
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.10107
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA1A, AXL, DRD1, DRD2, DRD3, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PPARA, SIGMAR1 5.80181
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 5.70107
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA1A, AXL, DRD1, DRD2, DRD3, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PPARA, SIGMAR1 5.60984
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR2A, HTR2B, HTR5A, HTR7 5.56324
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 5.45773
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, HSD17B1, HSD17B2, TYR, XDH 5.42399
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, XDH 5.30804
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA1A, AXL, DRD1, DRD2, DRD3, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PPARA, SIGMAR1 5.24043
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 4.4744
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TYR 4.2855
[MF] GO:0004930 None ADORA1, ADORA3, ADRA1A, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, SIGMAR1 3.91923
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 3.8595
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.85628
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, SRC 3.62055
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1 3.5032
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, CBR1, HSD17B1, HSD17B2, XDH 3.5027
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, SRC 3.4788
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 3.42781
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, FLT3, HTR2A, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SRC 3.42353
[MF] GO:0004952 None DRD1, DRD2, DRD3 3.26463
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TYR 3.24195
[MF] GO:0035240 None DRD1, DRD2, DRD3 3.1783
[MF] GO:0032403 protein complex binding ACHE, ADORA1, FLT3, HTR2A, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, SRC 2.93502
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.93245
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HSD17B1, HSD17B2 2.71397
[MF] GO:1901338 None DRD1, DRD2, DRD3 2.694
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, HSD17B1, SRC, XDH 2.35423
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, TYR, XDH 2.2593
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.24713
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.22806
[MF] GO:0004064 arylesterase activity CA1, CA2 2.14569
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2D6 2.13517
[MF] GO:0017171 serine hydrolase activity ACHE, F3, MMP1, MMP12, MMP2, MMP9 2.06905
[MF] GO:0005021 vascular endothelial growth factor-activated receptor activity FLT3, KDR 2.03725
[MF] GO:0001609 None ADORA1, ADORA3 2.03725


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Serotonergic synapse_Homo sapiens_hsa04726 APP, HTR6, HTR7, CYP2D6, ALOX5, ALOX15, HTR2B, HTR1A, HTR2A, HTR5A 10.547
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.7416
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 HTR6, HTR7, ADORA3, HTR2B, ADORA1, HTR1A, HTR2A, DRD1, HTR5A, DRD2, ADRA1A, DRD3 9.3953
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 8.6633
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 6.5501
Calcium signaling pathway_Homo sapiens_hsa04020 HTR6, HTR7, HTR2B, HTR2A, DRD1, HTR5A, ADRA1A 4.9245
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CBR1, CYP2D6, CYP1A2, CYP1A1, CYP1B1 4.5674
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.5674
Gap junction_Homo sapiens_hsa04540 SRC, HTR2B, HTR2A, DRD1, DRD2 4.2451
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, IGF1R 3.7144
cAMP signaling pathway_Homo sapiens_hsa04024 HTR6, ADORA1, HTR1A, DRD1, DRD2, PPARA 3.7256
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.2428
Metabolic pathways_Homo sapiens_hsa01100 CBR1, AKR1B10, ALOX5, HSD17B1, ALOX15, HSD17B2, CYP1A2, CYP1A1, AKR1B1, TYR, CYP19A1, XDH 3.0847
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.4501
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, DRD2, MET, IGF1R 2.7289
Chemical carcinogenesis_Homo sapiens_hsa05204 CBR1, CYP1A2, CYP1A1, CYP1B1 3.2177
Pathways in cancer_Homo sapiens_hsa05200 FLT3, MMP1, MMP2, MMP9, MET, IGF1R 2.3497
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, MMP9, MET, CDC25B 2.1248
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.8976
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15 2.3813
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, IGF1R 1.9423
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.087
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, HTR2B, HTR2A 1.9311
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, PIM1, F3 1.9226
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9 1.9311
Ras signaling pathway_Homo sapiens_hsa04014 HTR7, KDR, MET, IGF1R 1.8713
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.7089
Dopaminergic synapse_Homo sapiens_hsa04728 DRD1, DRD2, DRD3 1.7118
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1, ADRA1A 1.4661
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.4661
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.4661
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.4384
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 1.0707
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.1905
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.14
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.3821
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.3643
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 1.0707
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 1.1905
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.4551
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.3801
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1 1.3965
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 KDR, MET, IGF1R 0.8595
Cocaine addiction_Homo sapiens_hsa05030 DRD1, DRD2 1.5634
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.2969
Hepatitis B_Homo sapiens_hsa05161 SRC, MMP9 0.8941
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2D6, CYP1A2 1.378
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 1.0139
AMPK signaling pathway_Homo sapiens_hsa04152 ADRA1A, IGF1R 0.9965
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 1.0188
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.9076
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.9161
Alcoholism_Homo sapiens_hsa05034 DRD1, DRD2 0.7632
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8989
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 1.9129
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0284
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.5064
Taste transduction_Homo sapiens_hsa04742 HTR1A 0.5064
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.2952
Prostate cancer_Homo sapiens_hsa05215 IGF1R 0.5064
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7857
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4713
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5423
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.4713
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1 0.3572
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5064
Platelet activation_Homo sapiens_hsa04611 SRC 0.4577
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4925
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.346
Glioma_Homo sapiens_hsa05214 IGF1R 0.5423
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.5321
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5064
HIF-1 signaling pathway_Homo sapiens_hsa04066 IGF1R 0.4899
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.502
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.3562
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.4579
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3877
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4925
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5272
Measles_Homo sapiens_hsa05162 CSNK2A1 0.4414
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3788
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.4451
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1 0.4169
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4577
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 ADRA1A 0.4278
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 IGF1R 0.4384
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.4248
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5064
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.4384
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3877
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5473
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5 0.4579
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.4384
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.4451
Salivary secretion_Homo sapiens_hsa04970 ADRA1A 0.5064
Vascular smooth muscle contraction_Homo sapiens_hsa04270 ADRA1A 0.4577
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.3997
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5064
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.4169
Peroxisome_Homo sapiens_hsa04146 XDH 0.5064
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.502
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.4577
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5423
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5321
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.502
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3788
Axon guidance_Homo sapiens_hsa04360 MET 0.4533
Amphetamine addiction_Homo sapiens_hsa05031 DRD1 0.5423
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5423
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.5075
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.502
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.8713
Bile secretion_Homo sapiens_hsa04976 CA2 0.5321
Shigellosis_Homo sapiens_hsa05131 SRC 0.5423
Malaria_Homo sapiens_hsa05144 MET 0.6221
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6409
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.7462
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8398
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.2177


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)