Component: Aristolochia manshuriensis 关木通


Description of the Component

Component ID
TCMH718
Latin Name
Aristolochia manshuriensis
English Name
Manchurian dutchmanspipe
Chinese Pinyin Name
Guan Mu Tong
中文名
关木通
TCM Properties
Cold,Bitter
TCM Meridians
Bladder,Small Intestine,Heart
Therapeutic Class English
For promoting diuresis and penetrating dampness
Therapeutic Class Chinese
利水渗湿
Functions
remove heat from the heart, relieve dysuria and promote diuresis, stimulate menstrual discharge, and promote the flow of milk
Toxicity
NA
Geo-authentic habitats (道地产区)
NA
Reference
Chinese Pharmacopoeia (2015)
Barcode ID
GBVE2055-11
Barcode Source
BOLDSYSTEMS

TCM Prescriptions with the Component

Prescription ID Prescription English Name Prescription Chinese Name
TCMFx2947 An Yang Gao Yao 安阳膏药
TCMFx2971 An Yang Jing Zhi Ointment 安阳精制膏
TCMF2624 Anyang Jingzhi Plaster 安阳精制膏
TCMF1444 Anyang Jingzhi Plaster 安阳精制膏
TCMF3097 Bai Yi Zhen Jing Pills 白益镇惊丸
TCMFx1368 Dahuang Qingwei Pills 大黄清胃丸
TCMFx2274 Dahuang Qingwei Pills 大黄清胃丸
TCMF1370 Daochi Pills 导赤丸
TCMF2309 Daochi Pills 导赤丸
TCMFx3386 Die Da Tablets 跌打片
TCMF2914 E Jiao Sheng Hua Ointment 阿胶生化膏
TCMF3974 Er Long Pills 耳聋丸
TCMF2544 Fenqing Wulin Pills 分清五淋丸
TCMF3411 Fu Ming Tablets 复明片
TCMF3427 Fu Shen Ning Tablets 复肾宁片
TCMF2368 Fuke Fenqing Pills 妇科分清丸
TCMF1379 Fuke Fenqing Pills 妇科分清丸
TCMF4387 Huo Xue Li Shang Pills 活血理伤丸
TCMFx4657 Ji Kun Pills 济坤丸
TCMF4664 Ji Sheng Ju He Pills 济生橘核丸
TCMF4819 Jin Bu Huan Ointment 金不换膏
TCMF4148 Jin Sha Wu Lin Pills 金砂五淋丸
TCMF4667 Kun Ling Pills 坤灵丸
TCMF4100 Lian Qiao Bai Du Ointment 连翘败毒膏
TCMF4113 Lian Qiao Bai Du Pills 连翘败毒丸
TCMF4106 Lian Qiao Bai Du Tablets 连翘败毒片
TCMF4244 Ling Long Gan Mao Capsules 灵龙感冒胶囊
TCMF2116 Lithagogue Infusion 排石冲剂
TCMF4598 Long Dan Xie Gan Granules 龙胆泻肝颗粒
TCMF4614 Long Dan Xie Gan Pills 龙胆泻肝丸
TCMF4608 Long Dan Xie Gan Tablets 龙胆泻肝片
TCMF1363 Longdan Xiegan Pills 龙胆泻肝丸
TCMF2269 Longdan Xiegan Pills; Bolus of Gentian for Purging Liver-fire 龙胆泻肝丸
TCMF4450 Miao Ling Pills 妙灵丸
TCMFx4435 Pai Shi Granules 排石颗粒
TCMF5045 Qian Lie Hui Chun Capsules 前列回春胶囊
TCMF5427 Qing Lin Infusion 清淋冲剂
TCMFx5770 Qing Wei Pills 清胃丸
TCMF5872 Qing Xue Jie Du Pills 清血解毒丸
TCMF5880 Qing Xue Nei Xiao Pills 清血内消丸
TCMFx5800 Sheng Ru Tablets 生乳片
TCMFx5229 Tai He Miao Ling Pills 太和妙灵丸
TCMF5801 Tong Bian Qing Huo Pills 通便清火丸
TCMFx5163 Tou Gu Zhen Feng Pills 透骨镇风丸
TCMF5483 Wu Li Hui Chun Pills 五粒回春丸
TCMF5506 Wu Lin Pills 五淋丸
TCMF6626 Xiao Er Dao Chi Tablets 小儿导赤片
TCMF5981 Xiao Er Jin Dan 小儿金丹
TCMF5989 Xiao Er Jin Dan Tablets 小儿金丹片
TCMF6030 Xiao Feng Zhi Yang Granules 消风止痒颗粒
TCMF6625 Yan Yan Han Tablets 咽炎含片
TCMFx6048 Zhang Yi Powder 障翳散
TCMFx6833 Zhang Zhou Shen Qu 漳州神曲
TCMFx6026 Zhi Hong Pills 治红丸
TCMF6686 Zhui Feng Zhuang Gu Ointment 追风壮骨膏

Targeted Human Proteins by the Ingredient of Component

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT143 CA3 Carbonic anhydrase III Lyase P07451
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT166 AKR1C2 Aldo-keto reductase family 1 member C2 Oxidoreductase P52895
TCMT167 AKR1C3 Aldo-keto-reductase family 1 member C3 Oxidoreductase P42330
TCMT168 AKR1C4 Aldo-keto reductase family 1 member C4 Oxidoreductase P17516
TCMT171 PTPN6 Protein-tyrosine phosphatase 1C Hydrolase P29350
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT214 MGLL Monoglyceride lipase Unclassified Q99685
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT233 PTPN11 Protein-tyrosine phosphatase 2C Hydrolase Q06124
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT273 NR1H4 Bile acid receptor FXR Nuclear receptor Q96RI1
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT281 DPP4 Dipeptidyl peptidase IV Unclassified P27487
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT41 IDH1 Isocitrate dehydrogenase [NADP] cytoplasmic Oxidoreductase O75874
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT566 NOS2 Nitric oxide synthase, inducible Oxidoreductase P35228
TCMT598 TOP1 DNA topoisomerase I Isomerase P11387
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372


Targeted Pathogenic Microbes by the Ingredient of Component

Target ID Target Name
TCMT1107 Protease
TCMT1178 Actinomyces viscosus
TCMT1212 Verticillium dahliae
TCMT1218 Staphylococcus aureus
TCMT1229 Enterococcus faecalis
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1255 Human immunodeficiency virus 1
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1465 Entamoeba histolytica

Ingredient Structrues

Ingredient ID: TCMC948
Formula: C9H8O3

Ingredient ID: TCMC723
Formula: C17H11NO8

Ingredient ID: TCMC722
Formula: C17H11NO7

Ingredient ID: TCMC2543
Formula: C19H21NO5

Ingredient ID: TCMC2383
Formula: C20H23NO4

Ingredient ID: TCMC1839
Formula: C7H6O3

Ingredient ID: TCMC1786
Formula: C30H48O3

Ingredient ID: TCMC1767
Formula: C18H19NO4

Ingredient ID: TCMC1173
Formula: C10H10O4

Properties

Ingredient ID Formulae Name MW AlogP MlogP XlogP # HBA # HBD PSA # Rotatable Bond # Ring # Heacy Atom Lipinski RO5 Violation
TCMC722 C17H11NO7 Aristolochic Acid 341.05 0.0658 2.45 2.79 2 1 108.13 6 4 25 0
TCMC723 C17H11NO8 Aristolochic D 357.05 -0.3945 2.34 1.616 2 2 128.36 7 4 26 0
TCMC948 C9H8O3 Coumaric Acid 164.05 -0.339 2.12 1.886 2 2 57.53 4 1 12 0
TCMC1173 C10H10O4 Ferulic Acid 194.06 -0.3908 2.12 1.231 2 2 66.76 6 1 14 0
TCMC1767 C18H19NO4 N-Trans-Feruloyl Tyramine 313.13 -0.6499 2.89 3.109 2 3 82.28 10 2 23 0
TCMC1786 C30H48O3 Oleanolic_Acid 456.36 2.1298 4.43 9.052 3 2 57.53 10 5 33 1
TCMC1839 C7H6O3 Paraben 138.03 -0.7001 1.9 1.07 2 2 57.53 3 1 10 0
TCMC2383 C20H23NO4 Magnoflorine 342.17 -1.9843 3.11 1.008 0 2 58.92 8 4 25 0
TCMC2543 C19H21NO5 N-Trans-Feruloylmethoxytyramine 343.14 -0.7017 2.89 2.665 2 3 91.51 12 2 25 0

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1. General Information of the Component  
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3. Putative Targets  
4. Activity & References for Filtering Putative Targets  
5. Ingredient Data & Chemical Structure Information (Properties, InChI, InChIkey, SMILES, etc.)