Description of the Component
Component ID |
TCMH565 |
Latin Name |
Stephania tetrandra |
English Name |
Fourstamen stephania |
Chinese Pinyin Name |
Fang Ji |
中文名 |
防己 |
TCM Properties |
Cold,Pungent,Bitter |
TCM Meridians |
Bladder,Spleen,Kidney |
Therapeutic Class English |
For dispelling wind-dampness |
Therapeutic Class Chinese |
祛风湿 |
Functions |
cause diuresis and relieve rheumatic conditions |
Toxicity |
NA |
Geo-authentic habitats (道地产区) |
Hubei Province |
Reference |
Chinese Pharmacopoeia (2015) |
Barcode ID |
ITSAG893-14 |
Barcode Source |
BOLDSYSTEMS |
TCM Prescriptions with the Component
| Prescription ID | Prescription English Name | Prescription Chinese Name |
|---|---|---|
| TCMF2970 | Ba Xian You | 八仙油 |
| TCMFx3114 | Ban Feng He Yao Wine | 半枫荷药酒 |
| TCMF3084 | Bu Yi Huo Luo Pills | 补益活络丸 |
| TCMFx563 | Chang Wei Shi Capsule | 肠胃适胶囊 |
| TCMFx3091 | Chang Wei Shi Capsules | 肠胃适胶囊 |
| TCMF3355 | Die Da Feng Shi Yao Wine | 跌打风湿药酒 |
| TCMF3153 | Fang Ji Guan Jie Pills | 防己关节丸 |
| TCMF2895 | Fang Ji Huang Qi Decoction | 防己黄芪汤 |
| TCMFx3455 | Feng Shi Ning Tablets | 风湿宁片 |
| TCMF3487 | Feng Shi Sheng Yao Capsules | 风湿圣药胶囊 |
| TCMFx3542 | Feng Shi Zhen Tong Ointment | 风湿镇痛膏 |
| TCMFx370 | Feng Tong An Capsule | 风痛安胶囊 |
| TCMFx3564 | Feng Tong An Capsules | 风痛安胶囊 |
| TCMF3598 | Feng Tong Pills | 风痛丸 |
| TCMF3604 | Feng Tong Yao Wine | 风痛药酒 |
| TCMF745 | Gu Xian Tablet | 骨仙片 |
| TCMF3669 | Guan Jie Feng Tong Pills | 关节风痛丸 |
| TCMFx3678 | Guan Jie Jie Tong Ointment | 关节解痛膏 |
| TCMFx1109 | Hua Mo Yan Capsule | 滑膜炎胶囊 |
| TCMFx4873 | Hua Mo Yan Granules | 滑膜炎颗粒 |
| TCMFx1110 | Hua Mo Yan Granules | 滑膜炎颗粒 |
| TCMFx94 | Hua Mo Yan Tablets | 滑膜炎片 |
| TCMFx4311 | Huo Luo Ding | 活络酊 |
| TCMFx4437 | Huo Xue Zhen Tong Ointment | 活血镇痛膏 |
| TCMF4284 | Jin Gu Ning Cha Ji | 筋骨宁搽剂 |
| TCMFx4430 | Jing Zhi Gou Pi Ointment | 精制狗皮膏 |
| TCMF4557 | Jiu Zhi Xi Xian Cao Yao Wine | 九制豨莶草药酒 |
| TCMF2822 | Kai Xin Powder | 开心散 |
| TCMFx4027 | Li Xin Pills | 利心丸 |
| TCMF4244 | Ling Long Gan Mao Capsules | 灵龙感冒胶囊 |
| TCMFx4869 | Luo Fu Shan Feng Shi Gao Yao | 罗浮山风湿膏药 |
| TCMFx2466 | MHBZ Decoction | 麻黄白术汤 |
| TCMF2680 | Minor Prolong Life Decoction | 小续命汤 |
| TCMF2384 | Nerve Pain Relieving Decoction | 蠲痹镇痛汤 |
| TCMFx2573 | Period Pain Relieving Decoction | 通经止痛汤 |
| TCMFx1083 | Qing Gan Li Dan Capsule | 清肝利胆胶囊 |
| TCMFx82 | Qing Gan Li Dan Oral Liquid | 清肝利胆口服液 |
| TCMF5127 | Qing Shen Jian Fei Tablets | 轻身减肥片 |
| TCMFx5135 | Qing Shen Xiao Pang Pills | 轻身消胖丸 |
| TCMFx5131 | Qu Feng Sheng Shi Wine | 祛风胜湿酒 |
| TCMF2702 | Relax the Channels and Invigorate the Blood Decoction | 疏经活血汤 |
| TCMFx5634 | Ru Yi You | 如意油 |
| TCMFx5703 | Shang Ke Zhuang Gu Ointment | 伤科壮骨膏 |
| TCMFx5817 | Shang You Ca Ji | 伤友擦剂 |
| TCMFx7297 | Shang Zhong Xia Tong Yong Tong Feng Pills | 上中下通用痛风丸 |
| TCMF5123 | She Xiang Hai Ma Zhui Feng Ointment | 麝香海马追风膏 |
| TCMFx5312 | Shen Jin Dan Capsules | 伸筋丹胶囊 |
| TCMFx3699 | Shen Rong Zhuang Gu Pills | 参茸壮骨丸 |
| TCMF697 | Shen Yan Shu Tablet | 肾炎舒片 |
| TCMFx5862 | Shi Re Bi Granules | 湿热痹颗粒 |
| TCMFx1105 | Shi Re Bi Tablet | 湿热痹片 |
| TCMFx5869 | Shi Re Bi Tablets | 湿热痹片 |
| TCMF7291 | Shu Jing Huo Xue Decoction | 疏经活血汤 |
| TCMF2755 | Stephania and Astragalus Formula | 防己黄芪汤 |
| TCMFx5473 | Tian Ma Zhui Feng Ointment | 天麻追风膏 |
| TCMFx5125 | Tong Zhong Ling | 痛肿灵 |
| TCMFx5692 | Xi Huang Qing Xing Pills | 西黄清醒丸 |
| TCMFx5803 | Xi Lian Feng Shi Pills | 豨莶风湿丸 |
| TCMFx5796 | Xi Lian Feng Shi Tablets | 豨莶风湿片 |
| TCMFx6320 | Xiao Shuan Zai Zao Pills | 消栓再造丸 |
| TCMF2821 | Xiao Xu Ming Decoction | 小续命汤 |
| TCMF7302 | Xiao Xu Ming Decoction | 小续命汤 |
| TCMFx6476 | Xiao Zhi Pills | 消痔丸 |
| TCMFx6106 | Xin Xing Gou Pi Ointment | 新型狗皮膏 |
| TCMFx6167 | Xing Nao Zai Zao Capsules | 醒脑再造胶囊 |
| TCMFx6174 | Xing Nao Zai Zao Pills | 醒脑再造丸 |
| TCMF6178 | Yao Zhui Bi Tong Pills | 腰椎痹痛丸 |
| TCMFx2071 | Yi Chan Nephritis Combination Recipe | |
| TCMFx2000 | ZD Ginger Decoction | |
| TCMFx6640 | Zhi Tong Decoction | 止痛水 |
| TCMF6491 | Zhuang Gu Pills | 壮骨丸 |
Targeted Human Proteins by the Ingredient of Component
| Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
|---|---|---|---|---|
| TCMT1 | EHMT2 | Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 | Transferase | Q96KQ7 |
| TCMT101 | PTPN1 | Protein-tyrosine phosphatase 1B | Hydrolase | P18031 |
| TCMT11 | HIF1A | Hypoxia-inducible factor 1 alpha | Transcription factor | Q16665 |
| TCMT112 | ADORA3 | Adenosine A3 receptor | GPCR | P0DMS8 |
| TCMT125 | GBA | Beta-glucocerebrosidase | Hydrolase | P04062 |
| TCMT130 | ALOX5 | Arachidonate 5-lipoxygenase | Oxidoreductase | P09917 |
| TCMT131 | ACHE | Acetylcholinesterase | Hydrolase | P22303 |
| TCMT132 | BCHE | Butyrylcholinesterase | Hydrolase | P06276 |
| TCMT151 | PRKCA | Protein kinase C alpha | Kinase | P17252 |
| TCMT17 | POLB | DNA polymerase beta | Transferase | P06746 |
| TCMT18 | GAA | Lysosomal alpha-glucosidase | Hydrolase | P10253 |
| TCMT186 | MAOB | Monoamine oxidase B | Oxidoreductase | P27338 |
| TCMT195 | MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 | Kinase | Q02750 |
| TCMT2 | MAPT | Microtubule-associated protein tau | Unclassified | P10636 |
| TCMT213 | SLC22A1 | Solute carrier family 22 member 1 | Transporter | O15245 |
| TCMT217 | CYP2C8 | Cytochrome P450 2C8 | Oxidoreductase | P10632 |
| TCMT218 | CYP2B6 | Cytochrome P450 2B6 | Oxidoreductase | P20813 |
| TCMT219 | CYP1A2 | Cytochrome P450 1A2 | Oxidoreductase | P05177 |
| TCMT265 | GSK3B | Glycogen synthase kinase-3 beta | Kinase | P49841 |
| TCMT276 | SLCO2B1 | Solute carrier organic anion transporter family member 2B1 | Transporter | O94956 |
| TCMT277 | SLCO1B3 | Solute carrier organic anion transporter family member 1B3 | Transporter | Q9NPD5 |
| TCMT278 | SLCO1B1 | Solute carrier organic anion transporter family member 1B1 | Transporter | Q9Y6L6 |
| TCMT281 | DPP4 | Dipeptidyl peptidase IV | Unclassified | P27487 |
| TCMT295 | MMP1 | Matrix metalloproteinase-1 | Hydrolase | P03956 |
| TCMT296 | ADORA1 | Adenosine A1 receptor | GPCR | P30542 |
| TCMT306 | MMP2 | Matrix metalloproteinase-2 | Hydrolase | P08253 |
| TCMT307 | KCNH2 | HERG | Ion channel | Q12809 |
| TCMT31 | CYP2C19 | Cytochrome P450 2C19 | Oxidoreductase | P33261 |
| TCMT320 | MMP3 | Matrix metalloproteinase 3 | Hydrolase | P08254 |
| TCMT321 | MMP9 | Matrix metalloproteinase 9 | Hydrolase | P14780 |
| TCMT33 | CYP3A4 | Cytochrome P450 3A4 | Oxidoreductase | P08684 |
| TCMT34 | CYP2D6 | Cytochrome P450 2D6 | Oxidoreductase | P10635 |
| TCMT41 | IDH1 | Isocitrate dehydrogenase [NADP] cytoplasmic | Oxidoreductase | O75874 |
| TCMT42 | KMT2A | Histone-lysine N-methyltransferase MLL | Transferase | Q03164 |
| TCMT466 | MAPK9 | c-Jun N-terminal kinase 2 | Kinase | P45984 |
| TCMT479 | AKT1 | Serine/threonine-protein kinase AKT | Kinase | P31749 |
| TCMT507 | MAPK14 | MAP kinase p38 alpha | Kinase | Q16539 |
| TCMT559 | ADRB2 | Beta-2 adrenergic receptor | GPCR | P07550 |
| TCMT571 | ADORA2B | Adenosine A2b receptor | GPCR | P29275 |
| TCMT592 | XDH | Xanthine dehydrogenase | Oxidoreductase | P47989 |
| TCMT598 | TOP1 | DNA topoisomerase I | Isomerase | P11387 |
| TCMT624 | HSP90AB1 | Heat shock protein HSP 90-beta | Unclassified | P08238 |
| TCMT64 | PPARD | Peroxisome proliferator-activated receptor delta | Nuclear receptor | Q03181 |
| TCMT707 | ADORA2A | Adenosine A2a receptor | GPCR | P29274 |
| TCMT729 | PIK3CA | PI3-kinase p110-alpha subunit | Transferase | P42336 |
| TCMT730 | PIK3CB | PI3-kinase p110-beta subunit | Transferase | P42338 |
| TCMT740 | PIK3CG | PI3-kinase p110-gamma subunit | Transferase | P48736 |
| TCMT8 | KDM4E | Lysine-specific demethylase 4D-like | Oxidoreductase | B2RXH2 |
| TCMT80 | MAPK1 | MAP kinase ERK2 | Kinase | P28482 |
| TCMT87 | CYP2C9 | Cytochrome P450 2C9 | Oxidoreductase | P11712 |
Targeted Pathogenic Microbes by the Ingredient of Component
| Target ID | Target Name |
|---|---|
| TCMT1293 | Vaccinia virus |
| TCMT1438 | Plasmodium falciparum |
| TCMT1465 | Entamoeba histolytica |
Ingredient Structrues
Ingredient ID: TCMC850
Formula: C8H10N4O2
Ingredient ID: TCMC801
Formula: C29H50O
Ingredient ID: TCMC7274
Formula: C38H42N2O7
Ingredient ID: TCMC722
Formula: C17H11NO7
Ingredient ID: TCMC631
Formula: C5H5N5
Ingredient ID: TCMC6200
Formula: C39H45N2O6
Ingredient ID: TCMC6199
Formula: C38H43N2O6
Ingredient ID: TCMC6169
Formula: C36H36N2O5
Ingredient ID: TCMC4977
Formula: C37H40N2O6
Ingredient ID: TCMC4485
Formula: C20H24NO4
Ingredient ID: TCMC4223
Formula: C20H24NO4
Ingredient ID: TCMC2676
Formula: C19H23NO4
Ingredient ID: TCMC2666
Formula: C37H40N2O6
Ingredient ID: TCMC2516
Formula: C38H42N2O6
Ingredient ID: TCMC2383
Formula: C20H23NO4
Ingredient ID: TCMC2369
Formula: C38H42N2O6
Ingredient ID: TCMC2117
Formula: C22H26O8
Ingredient ID: TCMC1841
Formula: C7H8N4O2
Ingredient ID: TCMC1831
Formula: C21H22NO4
Ingredient ID: TCMC1663
Formula: C38H42N2O6
Ingredient ID: TCMC1652
Formula: C36H38N2O6
Ingredient ID: TCMC1625
Formula: C20H21NO4
Ingredient ID: TCMC1614
Formula: C19H19NO2
Ingredient ID: TCMC1424
Formula: C20H19NO4
Ingredient ID: TCMC1171
Formula: C37H40N2O6
Ingredient ID: TCMC1170
Formula: C38H42N2O6
Properties
| Ingredient ID | Formulae | Name | MW | AlogP | MlogP | XlogP | # HBA | # HBD | PSA | # Rotatable Bond | # Ring | # Heacy Atom | Lipinski RO5 Violation |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TCMC631 | C5H5N5 | Adenine | 135.05 | -1.1703 | 1.46 | -0.664 | 5 | 2 | 80.48 | 1 | 2 | 10 | 0 |
| TCMC722 | C17H11NO7 | Aristolochic Acid | 341.05 | 0.0658 | 2.45 | 2.79 | 2 | 1 | 108.13 | 6 | 4 | 25 | 0 |
| TCMC801 | C29H50O | Beta-Sitosterol | 414.39 | 1.3 | 4.54 | 11.595 | 1 | 1 | 20.23 | 13 | 4 | 30 | 1 |
| TCMC850 | C8H10N4O2 | Caffeine | 194.08 | -0.4311 | 1.68 | -0.625 | 6 | 0 | 58.44 | 3 | 2 | 14 | 0 |
| TCMC1170 | C38H42N2O6 | Fanchinin | 622.3 | 0.274 | 4.76 | 6.098 | 2 | 0 | 61.86 | 10 | 6 | 46 | 1 |
| TCMC1171 | C37H40N2O6 | Fangchinoline | 608.29 | -0.1345 | 4.65 | 5.579 | 2 | 1 | 72.86 | 9 | 6 | 45 | 1 |
| TCMC1424 | C20H19NO4 | Jatrorrhizine | 338.14 | -1.5606 | 3.11 | 1.039 | 2 | 1 | 49.2 | 6 | 4 | 25 | 0 |
| TCMC1614 | C19H19NO2 | N,N-Dimethyl-2-Naphtho[2,1-G][1,3]Benzodioxol-5-Ylethanamine | 293.14 | 0.1823 | 3.22 | 5.276 | 1 | 0 | 21.7 | 5 | 4 | 22 | 1 |
| TCMC1625 | C20H21NO4 | 339.15 | -0.0116 | 3.11 | 2.164 | 1 | 0 | 40.16 | 5 | 5 | 25 | 0 | |
| TCMC1652 | C36H38N2O6 | 594.27 | -0.543 | 4.54 | 5.06 | 2 | 2 | 83.86 | 8 | 6 | 44 | 1 | |
| TCMC1663 | C38H42N2O6 | 622.3 | 0.274 | 4.76 | 6.098 | 2 | 0 | 61.86 | 10 | 6 | 46 | 1 | |
| TCMC1831 | C21H22NO4 | Palmitine | 352.15 | -1.3839 | 3.22 | 2.969 | 0 | 0 | 40.8 | 8 | 4 | 26 | 0 |
| TCMC1841 | C7H8N4O2 | Paraxanthine | 180.06 | 0.0198 | 1.57 | -0.503 | 6 | 1 | 70.72 | 3 | 2 | 13 | 0 |
| TCMC2117 | C22H26O8 | Syringaresinol | 418.16 | -2.1258 | 3 | 0.796 | 2 | 2 | 95.84 | 12 | 4 | 30 | 0 |
| TCMC2369 | C38H42N2O6 | Isotetrandrine | 622.3 | 0.274 | 4.76 | 6.098 | 2 | 0 | 61.86 | 10 | 6 | 46 | 1 |
| TCMC2383 | C20H23NO4 | Magnoflorine | 342.17 | -1.9843 | 3.11 | 1.008 | 0 | 2 | 58.92 | 8 | 4 | 25 | 0 |
| TCMC2516 | C38H42N2O6 | Phaeanthine | 622.3 | 0.274 | 4.76 | 6.098 | 2 | 0 | 61.86 | 10 | 6 | 46 | 1 |
| TCMC2666 | C37H40N2O6 | 608.29 | -0.1345 | 4.65 | 5.579 | 2 | 1 | 72.86 | 9 | 6 | 45 | 1 | |
| TCMC2676 | C19H23NO4 | Sinomenine | 329.16 | -0.7813 | 3 | 1.294 | 3 | 1 | 59 | 6 | 4 | 24 | 0 |
| TCMC4223 | C20H24NO4 | Cyclanoline | 342.1705332 | -2.075 | 3.11 | 1.319 | 0 | 2 | 58.92 | 2 | 4 | 25 | 0 |
| TCMC4485 | C20H24NO4 | Cissamine | 342.1705332 | -2.075 | 3.11 | 1.319 | 0 | 2 | 58.92 | 2 | 4 | 25 | 0 |
| TCMC4977 | C37H40N2O6 | Menisidine | 610.3042871 | -3.0487 | 4.65 | 5.261 | 0 | 3 | 75.26 | 3 | 6 | 45 | 1 |
| TCMC6169 | C36H36N2O5 | Tiliacorine | 578.2780723 | -2.9969 | 4.65 | 4.873 | 0 | 3 | 66.03 | 2 | 8 | 43 | 0 |
| TCMC6199 | C38H43N2O6 | (+)-2-N-Methylfangchinoline | 624.3199371 | -2.9464 | 4.76 | 5.229 | 0 | 2 | 70.82 | 3 | 6 | 46 | 1 |
| TCMC6200 | C39H45N2O6 | (+)-2-N-Methyltetrandrine | 638.3355872 | -2.5379 | 4.87 | 5.748 | 0 | 1 | 59.82 | 4 | 6 | 47 | 1 |
| TCMC7274 | C38H42N2O7 | Fenfangjine A | 639.3070267 | -1.5882 | 4.65 | 5.258 | 0 | 1 | 82.88 | 4 | 6 | 47 | 1 |
Download Data
All data can be downloaded by:→ Selecting data type in the below download table
→ Then click the download button.
