TCM Prescription: Nerve Pain Relieving Decoction



Prescription Description
Prescription IDTCMF2384
Pinyin NameJuan Bi Zhen Tong Tang
Chinese Name蠲痹镇痛汤
English NameNerve Pain Relieving Decoction
Function Description
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH296 Radix aconiti 川乌 TCMH296
TCMH222 Aconitum carmichaelii 草乌 TCMH222 ITSAH2410-14
TCMH2239 Asarum sieboldii 细辛 TCMH2239 ITSAI1576-14
TCMH1588 Achyranthes bidentata 牛膝 TCMH1588 ITSAJ4612-14
TCMH211 Atractylodes lancea 苍术 TCMH211 ITSAN4439-14
TCMH565 Stephania tetrandra 防己 TCMH565 ITSAG893-14
TCMH1753 Boswellia carterii 乳香 TCMH1753
TCMH1508 Commiphora myrrha 没药 TCMH1508 MH522406
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH761 Cinnamomum cassia 桂枝 TCMH761 GQ255631
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT220 CYP2J2 Cytochrome P450 2J2 Oxidoreductase P51589
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT407 MYLK Myosin light chain kinase, smooth muscle Kinase Q15746
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT636 POLA1 DNA polymerase alpha subunit Transferase P09884
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT675 ADRB1 Beta-1 adrenergic receptor GPCR P08588
TCMT704 ERBB2 Receptor protein-tyrosine kinase erbB-2 Kinase P04626
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT725 CACNA1C Voltage-gated L-type calcium channel alpha-1C subunit Ion channel Q13936
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT778 KCNA5 Voltage-gated potassium channel subunit Kv1.5 Ion channel P22460
TCMT780 CACNA1D Voltage-gated L-type calcium channel alpha-1D subunit Ion channel Q01668
TCMT783 NR3C2 Mineralocorticoid receptor Nuclear receptor P08235
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT904 PGR Progesterone receptor Nuclear receptor P06401
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1293 Vaccinia virus
TCMT1294 Human parainfluenza virus 3
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, AR, BCL2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, GRIK5, GRM5, HSD11B2, HSD17B2, MMP2, MMP9, NR3C1, POLB, PPARA, TYR 8.33659
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRB1, AKR1B1, AR, BCL2, CA12, CA2, CA7, CACNA1C, CDK6, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, F3, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HSD11B1, HSD11B2, HSD17B1, HSD17B2, POLA1, POLB, PPARA, SLC1A1, TNKS, TNKS2, XDH 7.91822
[BP] GO:0033993 response to lipid ALPL, AR, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, NR3C1, TYR 7.41813
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, ESR1, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PPARA, TBXAS1 7.25642
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 7.19339
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, AR, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD11B2, HSD17B2, MMP2, NR3C1, POLB, PPARA, TYR 6.98607
[BP] GO:0007215 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 6.75278
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.75278
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ERBB2, ESR1, ESRRA, FABP3, FLT3, GRM5, HSD11B2, MMP2, NR3C1, PPARA 6.48683
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 6.44693
[BP] GO:0009725 response to hormone AKR1B1, ALPL, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, NR3C1, PPARA 6.4289
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA 6.36274
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 6.31559
[BP] GO:0048513 animal organ development ACHE, AR, BCL2, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ERBB2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, POLB, PPARA, TYR 6.10469
[BP] GO:0042221 response to chemical AKR1B1, ALPL, AR, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD11B2, HSD17B2, MMP2, MMP9, NR3C1, POLB, PPARA, TYR 5.95083
[BP] GO:0014070 response to organic cyclic compound ALPL, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FLT3, HSD11B2, NR3C1, TYR 5.95083
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.86603
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA 5.69535
[BP] GO:0009755 hormone-mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA 5.55653
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CACNA1C, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.15398
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 5.07966
[BP] GO:0006352 DNA-templated transcription, initiation AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA 4.83706
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, AR, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, F3, FABP3, FLT3, MMP12, MMP2, MMP9, PGR, XDH 4.65483
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, EGFR, GRM1, GRM3, GRM5, GRM8 4.65293
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRB1, AKR1B1, AR, BCL2, CA1, CA2, CACNA1C, CDK6, CSNK2A1, CYP1B1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, MMP2, MMP9, NR3C1, NR3C2, PGR, POLB, PPARA, PTPN1, TNKS, TNKS2 4.62937
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRB1, AKR1B1, AR, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, F3, FLT3, GRM1, MMP12, MMP9, PTPN1, TNKS, TNKS2, XDH 4.62937
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRB1, AKR1B1, AR, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, F3, FLT3, GRM1, MMP12, MMP9, PTPN1, TNKS, TNKS2, XDH 4.607
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.60227
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, CA2, CA7, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8 4.57516
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, CA2, CA7, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8 4.57516
[BP] GO:0008152 metabolic process ACHE, ADORA1, ADRB1, AKR1B1, AKR1B10, ALPL, AOX1, AR, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, POLA1, POLB, PPARA, PTPN1, TBXAS1, TNKS, TNKS2, TYR, XDH 4.54756
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.50395
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.3377
[BP] GO:0030522 intracellular receptor signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, PGR, PPARA 4.30302
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.24847
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRB1, AKR1B1, AR, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GRIK5, GRM1, GRM5, MMP1, MMP12, MMP2, MMP9, NR3C1, PGR, PPARA, PTPN1, TNKS, TNKS2, XDH 4.15085
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRB1, AKR1B1, AR, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, MMP1, MMP12, MMP2, MMP9, NR3C1, PGR, PPARA, PTPN1, SLC1A1, TNKS, TNKS2, XDH 3.96804
[BP] GO:0042592 homeostatic process ADORA1, ADRB1, AKR1B1, BCL2, CA12, CA2, CA7, CACNA1C, EGFR, ESR1, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, POLA1, POLB 3.9017
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRB1, AKR1B1, AR, BCL2, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, ESR1, ESR2, F3, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, MMP12, MMP9, PTPN1, TNKS, TNKS2, XDH 3.9017
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRB1, AKR1B1, AR, BCL2, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, ESR1, ESR2, F3, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, MMP12, MMP9, PTPN1, TNKS, TNKS2, XDH 3.79461
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, AR, BCL2, CA2, CACNA1C, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, MMP9, PGR, POLB, PPARA, TYR 3.78208
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, AOX1, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, GBA2, PPARA, TBXAS1, TYR, XDH 3.77694
[BP] GO:0032502 developmental process ACHE, ADORA1, ADRB1, AKR1B1, ALPL, AR, BCL2, CA2, CA9, CACNA1C, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD17B2, MMP2, MMP9, PGR, POLB, PPARA, TNKS2, TYR 3.63894
[BP] GO:0048545 response to steroid hormone ALPL, AR, BCL2, CA2, EGFR, FLT3, HSD11B2, NR3C1 3.63894
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, ALPL, AR, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, F3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HSD11B2, HSD17B2, MMP12, MMP2, MMP9, NR3C1, POLA1, POLB, PPARA, PTPN1, TYR 3.53478
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AR, BCL2, CDC25B, CDK6, CSNK2A1, EGFR, ERBB2, ESR1, F3, FLT3, MMP12, MMP2, MMP9 3.45391
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.44768
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, SLC1A1 3.4326
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, AR, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, ESR1, FABP4, FLT3, GRIK5, GRM5, MMP2, MMP9, NR3C1 3.4326
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TBXAS1, TYR, XDH 3.4144
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRB1, AKR1B1, AR, BCL2, CSNK2A1, CYP1B1, EGFR, ERBB2, F3, FLT3, GRM1, MMP12, MMP9, PTPN1, TNKS, TNKS2, XDH 3.32919
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, AR, BCL2, CDK6, CYP1A1, CYP1B1, EGFR, ERBB2, ESR1, FABP4, FLT3, GRIK5, GRM5, MMP2, NR3C1 3.26271
[BP] GO:0032501 multicellular organismal process ADORA1, ADRB1, AKR1B1, AKR1B10, ALPL, AR, BCL2, CACNA1C, CYP19A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRB, F3, FABP4, GRM1, GRM5, GRM8, HSD11B2, HSD17B2, MMP1, MMP12, MMP2, MMP9, PPARA, TNKS2, TYR 3.24245
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, AR, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, ESR1, FABP4, FLT3, GRIK5, GRM1, GRM5, MMP2, MMP9, NR3C1, POLA1, POLB, PTPN1 3.24245
[BP] GO:0009611 response to wounding ACHE, ADORA3, BCL2, CYP1A1, EGFR, ERBB2, PPARA 3.21758
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRB1, AR, BCL2, CDC25B, EGFR, ERBB2, ESRRB, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, MMP9, PPARA, PTPN1, XDH 3.15779
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRB1, AR, BCL2, CDC25B, EGFR, ERBB2, ESRRB, FABP3, FLT3, GRM1, GRM5, MMP9, PTPN1, XDH 3.13767
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRB1, AR, BCL2, CDC25B, EGFR, ERBB2, ESRRB, FABP3, FLT3, GRM1, GRM5, MMP9, PTPN1, XDH 3.13767
[BP] GO:0035265 organ growth AR, BCL2, CYP19A1, ESR1 3.13486
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRB1, AR, BCL2, CDC25B, EGFR, ERBB2, ESRRB, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, MMP9, PPARA, PTPN1, XDH 3.13104
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, FABP3, FABP4, FUT7, GBA2, PPARA, TBXAS1 3.12317
[BP] GO:0023052 None ADORA1, ADRB1, AR, CACNA1C, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, PGR, SLC1A1 3.12317
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, GBA2 3.10817
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRB1, AR, BCL2, CDC25B, CSNK2A1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRM1, GRM5, MMP12, MMP9, NR3C1, PGR, PPARA, PTPN1, TNKS, TNKS2, XDH 3.02933
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.02933
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5 3.02066
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.02066
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, BCL2, CA1, CSNK2A1, EGFR, ERBB2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, MMP2, MMP9, PTPN1, TNKS, TNKS2 3.00378
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRB1, AKR1B1, AR, BCL2, CSNK2A1, CYP1B1, EGFR, ERBB2, ESRRA, F3, FABP4, FLT3, GRM1, MMP12, MMP2, MMP9, PTPN1, TNKS, TNKS2, XDH 2.96685
[BP] GO:0007154 None ADORA1, ADRB1, AR, BCL2, CACNA1C, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, PGR, SLC1A1 2.93635
[BP] GO:0007193 None ADORA1, GRM1, GRM3, GRM5, GRM8 2.92136
[BP] GO:0060736 prostate gland growth AR, CYP19A1, ESR1 2.90921
[BP] GO:0060078 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5 2.90168
[BP] GO:0030518 intracellular steroid hormone receptor signaling pathway AR, ESR1, ESR2, NR3C1, PGR 2.87814
[BP] GO:0007267 None ADORA1, ADRB1, AR, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, PGR, SLC1A1 2.84463
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, EGFR, FLT3, HSD11B2, NR3C1 2.83443
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRB1, AR, BCL2, CDC25B, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GRM1, GRM5, MMP12, MMP9, NR3C1, PGR, PPARA, PTPN1, TNKS, TNKS2, XDH 2.79047
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.70461
[BP] GO:0009115 None AOX1, XDH 2.67922
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, SLC1A1 2.61401
[BP] GO:0048878 chemical homeostasis AKR1B1, BCL2, CA12, CA2, CA7, CACNA1C, EGFR, ESR1, FABP3, FABP4, GRIK5, GRM1, GRM5 2.60951
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, EGFR, FLT3, HSD11B2, NR3C1 2.60951
[BP] GO:0007188 None ADORA1, ADRB1, GRM1, GRM3, GRM5, GRM8 2.59722
[BP] GO:0050678 None AR, CDK6, EGFR, ERBB2, F3, MMP12, PGR, XDH 2.59275
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRB1, AR, BCL2, CDC25B, CSNK2A1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GRM1, GRM5, MMP12, MMP9, NR3C1, PGR, PPARA, PTPN1, TNKS, TNKS2, XDH 2.5796
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRB1, AKR1B1, AR, BCL2, CYP1B1, EGFR, ERBB2, F3, FLT3, GRM1, PTPN1, XDH 2.48494
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, AR, BCL2, CDC25B, EGFR, ERBB2, ESRRB, FLT3, GRM1, GRM5, MMP9, PTPN1, XDH 2.43483
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, AR, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, NR3C1 2.42425
[BP] GO:0010035 response to inorganic substance AKR1B1, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, MMP9 2.41573
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, GBA2, MMP1, MMP12, MMP2, MMP9, XDH 2.40776
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR 2.40755
[BP] GO:0009628 response to abiotic stimulus ADORA1, ADRB1, AKR1B1, BCL2, CA2, CYP1A1, EGFR, GRM1, HSD11B2, MMP2, POLB, PPARA, TYR 2.38748
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, AOX1, AR, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, POLA1, POLB, PPARA, PTPN1, TBXAS1, TNKS, TNKS2, TYR, XDH 2.37946
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALPL, AOX1, AR, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GBA2, HSD17B1, HSD17B2, MMP1, MMP2, NR3C1, NR3C2, PGR, POLA1, POLB, PPARA, PTPN1, TBXAS1, TNKS, TNKS2, TYR, XDH 2.36911
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.34602
[BP] GO:0032844 regulation of homeostatic process ADORA1, BCL2, CA2, CA7, CACNA1C, CDK6, EGFR, TNKS, TNKS2 2.34602
[BP] GO:0044236 multicellular organism metabolic process ADRB1, MMP1, MMP12, MMP2, MMP9 2.34602
[BP] GO:1901654 None AKR1B1, AR, CA9, CSNK2A1, EGFR, NR3C1 2.33691
[BP] GO:0003006 developmental process involved in reproduction ALPL, AR, BCL2, CDC25B, CYP19A1, EGFR, ESR1, ESRRB, HSD17B2, PGR 2.33691
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.33563
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, AR, BCL2, CA1, CA12, CA2, CA7, CA9, CACNA1C, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, POLA1, POLB, PPARA, PTPN1, SLC1A1, TNKS, TNKS2, XDH 2.33494
[BP] GO:0042493 response to drug AKR1B1, BCL2, CA9, CDK6, CYP1A1, CYP1B1, EGFR, FABP3, HSD11B2, NR3C1, POLB 2.32356
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, TBXAS1 2.32043
[BP] GO:0099566 None GRM1, GRM5 2.32043
[BP] GO:0060748 None AR, PGR 2.32043
[BP] GO:0046110 None AOX1, XDH 2.32043
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.32043
[BP] GO:0007187 None ADORA1, ADRB1, GRM1, GRM3, GRM5, GRM8 2.31319
[BP] GO:0022414 reproductive process AKR1B1, ALPL, AR, BCL2, CDC25B, CYP19A1, CYP1A1, EGFR, ESR1, ESRRB, HSD11B2, HSD17B2, MMP2, MMP9, PGR 2.31271
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AR, CDK6, CYP1B1, EGFR, ESR1, GRIK5, GRM5, MMP2, MMP9, NR3C1 2.26526
[BP] GO:0001503 ossification ALPL, BCL2, EGFR, MMP2, MMP9 2.25243
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRB1, AR, BCL2, CDC25B, CSNK2A1, EGFR, ERBB2, ESR1, F3, FABP4, FLT3, GRM1, GRM3, GRM5, MMP9, PTPN1, TNKS, XDH 2.24111
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, AR, BCL2, CDC25B, CSNK2A1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRM1, GRM5, MMP12, MMP9, NR3C1, PGR, PPARA, PTPN1, TNKS, TNKS2, XDH 2.2377
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.20578
[BP] GO:0044093 positive regulation of molecular function ADORA1, ADRB1, AR, BCL2, CDC25B, EGFR, ERBB2, ESR1, ESR2, F3, FLT3, GRM1, GRM5, MMP9, PTPN1, TNKS, XDH 2.20349
[BP] GO:0022612 gland morphogenesis BCL2, EGFR, POLB 2.15718
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, POLB, PPARA 2.15715
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.10952
[BP] GO:0008283 cell proliferation ACHE, AR, BCL2, CYP1A1, EGFR, ERBB2, ESR1, FLT3, POLA1, TYR 2.10488
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.10045
[BP] GO:0070213 None TNKS, TNKS2 2.09267
[BP] GO:0006145 None AOX1, XDH 2.09267
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.09267
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, AR, BCL2, CDC25B, EGFR, ERBB2, FLT3, GRM1, GRM5, MMP9, PTPN1, XDH 2.09267
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.08871
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.07711
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, BCL2, CYP19A1, CYP1A1, CYP1B1, GBA2, TYR 2.0684
[BP] GO:0050801 ion homeostasis BCL2, CA12, CA2, CA7, CACNA1C, EGFR, ESR1, FABP3, GRM1, GRM5 2.05213
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 3.25149
[CC] GO:0098590 plasma membrane region ADORA1, CA2, CA4, CA9, EGFR, ERBB2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SLC1A1 3.06322
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, GBA2, GRIA2, HSD11B1, HSD11B2, HSD17B2, NR3C2, TBXAS1 2.71181
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ADRB1, ALPL, AR, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, ESR1, F3, FLT3, FUT7, GBA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD11B1, HSD11B2, HSD17B2, MMP2, NR3C2, PGR, PTPN1, SLC1A1, TBXAS1, TNKS, TNKS2, TYR 2.70459
[CC] GO:0044432 endoplasmic reticulum part BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FLT3, GBA2, GRIA2, HSD11B1, HSD11B2, HSD17B2, NR3C2, PTPN1, TBXAS1 2.47598
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, ERBB2 2.27921
[CC] GO:0097060 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 2.18206
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, ADRB1, AKR1B1, AKR1B10, AOX1, AR, BCL2, CA1, CA2, CA4, CA7, CACNA1C, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, GBA2, GRIA2, GRIA4, GRIK5, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MMP2, MMP9, NR3C1, NR3C2, PGR, POLA1, PTPN1, TBXAS1, TNKS, TNKS2, TYR, XDH 2.16878
[CC] GO:0014069 None ADORA1, CACNA1C, GRIK5, GRM1, GRM3, GRM5 2.15718
[CC] GO:0099572 None ADORA1, CACNA1C, GRIK5, GRM1, GRM3, GRM5 2.15718
[MF] GO:0046914 transition metal ion binding AOX1, AR, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PPARA, PTPN1, TBXAS1, TNKS, TYR, XDH 14.6859
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.61946
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PPARA, PTPN1, TNKS 9.11966
[MF] GO:0005496 steroid binding AR, ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, NR3C1, NR3C2, PGR 8.84617
[MF] GO:0003707 steroid hormone receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA 8.8266
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 8.03736
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRB1, AR, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, NR3C1, NR3C2, PGR, PPARA 7.1079
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRB1, AR, CDK6, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, NR3C1, NR3C2, PGR, PPARA 6.74868
[MF] GO:0043167 ion binding ACHE, ALPL, AOX1, AR, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HSD17B1, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, POLA1, POLB, PPARA, PTPN1, SLC1A1, TBXAS1, TNKS, TNKS2, TYR, XDH 6.74868
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9, POLB 6.74478
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding AR, ESR1, ESR2, ESRRA, ESRRB, PGR, PPARA 6.53287
[MF] GO:0004879 nuclear receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, PGR, PPARA 6.53287
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRB1, AR, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, NR3C1, NR3C2, PGR, PPARA 6.36274
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.29672
[MF] GO:0043169 cation binding ACHE, ALPL, AOX1, AR, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, POLA1, POLB, PPARA, PTPN1, SLC1A1, TBXAS1, TNKS, TNKS2, TYR, XDH 6.20907
[MF] GO:0046872 metal ion binding ALPL, AOX1, AR, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, POLA1, POLB, PPARA, PTPN1, SLC1A1, TBXAS1, TNKS, TNKS2, TYR, XDH 5.87331
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRB1, AR, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, NR3C1, NR3C2, PGR, PPARA 5.6936
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 5.00573
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, AOX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, F3, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MMP1, MMP12, MMP2, MMP9, POLA1, POLB, PTPN1, TBXAS1, TNKS, TNKS2, TYR, XDH 4.99337
[MF] GO:0008289 lipid binding AR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, HSD11B2, HSD17B1, NR3C1, NR3C2, PGR, PPARA 4.65483
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TBXAS1, TYR, XDH 4.34777
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9, POLB 4.15108
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, TYR 3.59122
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.50728
[MF] GO:0005506 iron ion binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, XDH 3.46922
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.32919
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.26782
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.1708
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.13566
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B2, HSD17B1, POLA1, TBXAS1, XDH 3.00378
[MF] GO:0042562 hormone binding ACHE, AR, EGFR, HSD17B1, NR3C1 2.71181
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.67922
[MF] GO:0003845 None HSD11B1, HSD11B2 2.67922
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, TYR 2.60951
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.59275
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.56348
[MF] GO:0019899 enzyme binding ADRB1, AR, BCL2, CDC25B, CYP1A1, CYP1A2, EGFR, ERBB2, ESR1, ESR2, ESRRB, F3, GRM5, NR3C1, PGR, POLA1, POLB, PPARA, PTPN1, TNKS2 2.46867
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.32356
[MF] GO:0030594 None GRIA2, GRIA4, GRIK5, GRM1, GRM5 2.32043
[MF] GO:0099583 None GRM1, GRM5 2.32043
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.31922
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.31922
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRB1, EGFR, ERBB2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 2.12212
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRB1, EGFR, ERBB2, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 2.12212
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.09267
[MF] GO:0004971 None GRIA2, GRIA4 2.09267
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1 2.07338


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.1135
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 9.0024
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, CACNA1C, GRM1, GRIA4 8.2545
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GRM3, GRIA2, GRM5, ADORA3, GRIK5, GRM8, ADORA1, ADRB1, NR3C1, GRM1, GRIA4 7.2977
Bladder cancer_Homo sapiens_hsa05219 MMP1, MMP2, ERBB2, MMP9, EGFR 5.2019
Ovarian steroidogenesis_Homo sapiens_hsa04913 HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1 4.8395
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, TYR, GBA2, CYP19A1, HSD11B1, POLA1, FUT7, AKR1B10, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 4.5447
Estrogen signaling pathway_Homo sapiens_hsa04915 MMP2, MMP9, ESR1, GRM1, EGFR, ESR2 4.7592
Pathways in cancer_Homo sapiens_hsa05200 AR, CDK6, FLT3, MMP1, MMP2, ERBB2, BCL2, MMP9, EGFR 4.0652
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, CACNA1C, GRM1, GRIA4 3.5854
Calcium signaling pathway_Homo sapiens_hsa04020 GRM5, ERBB2, ADRB1, CACNA1C, GRM1, EGFR 3.4939
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 3.9003
cAMP signaling pathway_Homo sapiens_hsa04024 GRIA2, ADORA1, ADRB1, CACNA1C, PPARA, GRIA4 3.2845
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, ERBB2, BCL2, CYP1B1, MMP9, EGFR, CDC25B 3.2817
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, CACNA1C, GRM1 3.2069
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, GRM8, GRM1, EGFR 3.1082
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP1A2, CYP1A1, CYP1B1 3.1082
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, ERBB2, EGFR 3.1082
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.1591
Prostate cancer_Homo sapiens_hsa05215 AR, ERBB2, BCL2, EGFR 2.8871
Proteoglycans in cancer_Homo sapiens_hsa05205 MMP2, ERBB2, MMP9, ESR1, EGFR 2.4966
Gap junction_Homo sapiens_hsa04540 GRM5, ADRB1, GRM1, EGFR 2.8871
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP1A2, CYP1A1, CYP1B1 2.9851
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6, ERBB2, EGFR 2.3399
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1, ADRB1, CACNA1C 2.0052
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1, ADRB1 2.3399
Pancreatic cancer_Homo sapiens_hsa05212 CDK6, ERBB2, EGFR 2.1898
Renin secretion_Homo sapiens_hsa04924 ADORA1, ADRB1, CACNA1C 2.1898
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, CACNA1C, GRIA4 2.1898
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.1898
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, ERBB2, EGFR 2.1898
GnRH signaling pathway_Homo sapiens_hsa04912 MMP2, CACNA1C, EGFR 1.8499
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, F3 1.7592
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, CACNA1C, GRIA4 1.8097
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, BCL2, CACNA1C 1.6809
HIF-1 signaling pathway_Homo sapiens_hsa04066 ERBB2, BCL2, EGFR 1.7469
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.62
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, CACNA1C, GRIA4 1.56
Hepatitis B_Homo sapiens_hsa05161 CDK6, BCL2, MMP9 1.4431
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2, ADRB1, CACNA1C 1.4431
Focal adhesion_Homo sapiens_hsa04510 ERBB2, BCL2, EGFR 1.1525
MAPK signaling pathway_Homo sapiens_hsa04010 CACNA1C, EGFR, CDC25B 0.9614
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PGR, CDC25B 1.0353
Taste transduction_Homo sapiens_hsa04742 CACNA1C, GRM1 1.1322
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 0.9654
ErbB signaling pathway_Homo sapiens_hsa04012 ERBB2, EGFR 1.109
Glioma_Homo sapiens_hsa05214 CDK6, EGFR 1.2842
Melanoma_Homo sapiens_hsa05218 CDK6, EGFR 1.2357
Prolactin signaling pathway_Homo sapiens_hsa04917 ESR1, ESR2 1.232
Oocyte meiosis_Homo sapiens_hsa04114 AR, PGR 0.8976
Dilated cardiomyopathy_Homo sapiens_hsa05414 ADRB1, CACNA1C 1.0889
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2 1.1111
FoxO signaling pathway_Homo sapiens_hsa04068 GRM1, EGFR 0.8564
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1 0.8453
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.9194
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 1.0699
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.8564
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 0.8976
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1 1.3416
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CDK6, BCL2, EGFR 0.7567
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, AOX1 0.7729
Oxytocin signaling pathway_Homo sapiens_hsa04921 CACNA1C, EGFR 0.7729
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1 1.2513
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.6467
Purine metabolism_Homo sapiens_hsa00230 POLA1, XDH 0.7203
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3472
Endometrial cancer_Homo sapiens_hsa05213 ERBB2, EGFR 1.4431
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9 0.7093
Viral carcinogenesis_Homo sapiens_hsa05203 POLB, CDK6 0.6467
Endocytosis_Homo sapiens_hsa04144 ADRB1, EGFR 0.5278
HTLV-I infection_Homo sapiens_hsa05166 POLB 0.2437
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, EGFR 0.5278
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2 1.4571
Ras signaling pathway_Homo sapiens_hsa04014 EGFR 0.2774
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 EGFR 0.292
Rap1 signaling pathway_Homo sapiens_hsa04015 EGFR 0.2933
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.3178
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3281
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2, BCL2 1.4431
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.3512
Tuberculosis_Homo sapiens_hsa05152 BCL2 0.3373
Alzheimer's disease_Homo sapiens_hsa05010 CACNA1C 0.3512
Tight junction_Homo sapiens_hsa04530 CSNK2A1 0.4
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.4
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.3823
Apoptosis_Homo sapiens_hsa04210 BCL2 0.4
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB 0.4
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.4
Platelet activation_Homo sapiens_hsa04611 TBXAS1 0.437
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.4395
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.454
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 ESR1 0.4395
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2, NR3C2 1.62
Toxoplasmosis_Homo sapiens_hsa05145 BCL2 0.4395
Vascular smooth muscle contraction_Homo sapiens_hsa04270 CACNA1C 0.4395
Serotonergic synapse_Homo sapiens_hsa04726 CACNA1C 0.4509
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4782
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.4782
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4782
Pyrimidine metabolism_Homo sapiens_hsa00240 POLA1 0.4675
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4868
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4865
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4996
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.4992
GABAergic synapse_Homo sapiens_hsa04727 CACNA1C 0.4996
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4996
Salivary secretion_Homo sapiens_hsa04970 ADRB1 0.4996
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.7592
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6 0.5278
Insulin secretion_Homo sapiens_hsa04911 CACNA1C 0.4996
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4996
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 CACNA1C 0.5053
Peroxisome_Homo sapiens_hsa04146 XDH 0.5039
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.4996
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5278
Cardiac muscle contraction_Homo sapiens_hsa04260 CACNA1C 0.5117
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5278
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.5109
Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 CACNA1C 0.5039
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.6084
Bile secretion_Homo sapiens_hsa04976 CA2 0.5278
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.5278
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 EGFR 0.5278
Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 CACNA1C 0.5278
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.5585
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.6809
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3 0.5827
Arachidonic acid metabolism_Homo sapiens_hsa00590 TBXAS1 0.5585
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7357
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6676
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6467
Type II diabetes mellitus_Homo sapiens_hsa04930 CACNA1C 0.6467
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9473
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6467
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6467
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.6467
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.7964
DNA replication_Homo sapiens_hsa03030 POLA1 0.7203
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7662
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.7778
Base excision repair_Homo sapiens_hsa03410 POLB 0.7508
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7778
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8011
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7964
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.9194
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0003
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.1082
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.2836


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)