TCM Prescription: Shu Jing Huo Xue Decoction



Prescription Description
Prescription IDTCMF7291
Pinyin NameShu Jing Huo Xue Tang
Chinese Name疏经活血汤
English NameShu Jing Huo Xue Decoction
Function Description关节痛, 腰痛, 筋肉痛, 遍身走痛
IndicationsLumbago disorder
Disease ICD-11 Category SC61 [Lumbago disorder (TM1), 腰痛 (TM1) ];
Human Tissues Associated with Indication
ReferenceTaiwan Herbal Pharmacopeia 2nd Edition English Version
Reference Book/linkhttps://www.mohw.gov.tw/cp-3690-39025-2.html
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH104 Paeonia lactiflora 白芍 TCMH104 ITSAH2416-14
TCMH1896 Radix rehmanniae 生地黄 TCMH1896
TCMH211 Atractylodes lancea 苍术 TCMH211 ITSAN4439-14
TCMH1588 Achyranthes bidentata 牛膝 TCMH1588 ITSAJ4612-14
TCMH243 Pericarpium citri reticulatae 陈皮 TCMH243
TCMH2073 Prunus persica 桃仁 TCMH2073 ITSAN1047-14
TCMH2166 Clematis chinensis 威灵仙 TCMH2166
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH565 Stephania tetrandra 防己 TCMH565 ITSAG893-14
TCMH1665 Notopterygium incisum 羌活 TCMH1665 JF755946
TCMH562 Saposhnikovia divaricata 防风 TCMH562 ITSAE3225-14
TCMH118 Angelica dahurica 白芷 TCMH118 ITSAK3312-14
TCMH1317 Gentiana scabra 龙胆 TCMH1317 ITSAP4208-14
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH1903 Zingiber officinale 生姜 TCMH1903 ITSAO3969-14
Reference: Taiwan Herbal Pharmacopeia 2nd Edition English Version

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT301 PTGES Prostaglandin E synthase Isomerase O14684
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT316 MTNR1A Melatonin receptor 1A GPCR P48039
TCMT317 MTNR1B Melatonin receptor 1B GPCR P49286
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT678 XIAP Inhibitor of apoptosis protein 3 Transferase P98170
TCMT679 MPEG1 Macrophage-expressed gene 1 protein Unclassified Q2M385
TCMT680 KAT2B Histone acetyltransferase PCAF Transferase Q92831
TCMT689 TGM2 Protein-glutamine gamma-glutamyltransferase Transferase P21980
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT807 SLC22A12 Solute carrier family 22 member 12 Transporter Q96S37
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1186 Plasmodium yoelii yoelii
TCMT1188 Leishmania braziliensis
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1283 Human enterovirus 71
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1293 Vaccinia virus
TCMT1294 Human parainfluenza virus 3
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.6193
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MAOA, MET, MTNR1B, PPARA, SLC1A1, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1, XDH 10.4174
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ESR1, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MET, PPARA, PTGES, TBXAS1, TRPV1 9.99844
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 9.8787
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, AXL, BCL2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, GRIK5, GRM5, HSD11B2, HSD17B2, IGF1R, INSR, MMP2, MMP9, PPARA, PTGES, SRC, TEK, TRPV1, TYR 8.71255
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 8.62155
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD11B2, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, PPARA, PTGES, SMAD3, SRC, TEK, TRPV1, TYR 8.54682
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGES, TBXAS1 8.45627
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FUT7, GBA2, HSPA1A, PIM1, PPARA, PTGES, TBXAS1, TYR, XDH 8.13865
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, ALOX15, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, F3, FLT3, GPR35, GRM1, HCAR2, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 7.90237
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, ALOX15, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, F3, FLT3, GPR35, GRM1, HCAR2, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 7.87842
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGES, TBXAS1 7.7183
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGES, TBXAS1 7.47025
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, MTNR1B, NUAK1, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 7.45392
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, MTNR1B, NUAK1, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 7.29847
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 7.19669
[BP] GO:0042221 response to chemical AKR1B1, ALOX15, ALPL, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD11B2, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, PPARA, PTGES, SMAD3, SRC, TEK, TRPV1, TYR 6.97474
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, EGFR, ESR1, ESRRA, F3, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, PIM1, PTGES, SMAD3, SRC, TEK, XDH 6.72597
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, GRM5, HSD11B2, IGF1R, INSR, MMP2, PPARA, SMAD3, SRC, TEK, TRPV1 6.72597
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MAOA, NQO2, TBXAS1, TYR, XDH 6.67703
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, PTGES, SRC, TYR 6.63269
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MAOA, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIM1, PPARA, PTGES, PTPN1, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TRPV1, TYR, XDH 6.53041
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FLT3, GPR35, GRIK5, GRM1, GRM5, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, MTNR1A, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1, XDH 6.49857
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGES, TBXAS1 6.43084
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, INSR, PPARA, SRC, TEK, TRPV1 6.43084
[BP] GO:0007215 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 6.2816
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, ALOX15, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, F10, F3, FLT3, GPR35, GRM1, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 6.12532
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGES, TBXAS1 6.01595
[BP] GO:0014070 response to organic cyclic compound ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FLT3, HSD11B2, PTGES, SRC, TEK, TRPV1, TYR 5.82762
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GPR35, GRIK5, GRM1, GRM5, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, MTNR1A, PIM1, PPARA, PTPN1, SLC1A1, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1, XDH 5.79867
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA, SLC1A1, TRPV1 5.66085
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GRIK5, HCAR2, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TRPV1, XDH 5.50491
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, FABP3, FABP4, FUT7, GBA2, MET, PPARA, PTGES, TBXAS1 5.50491
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GRIK5, HCAR2, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, TRPV1, XDH 5.50491
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, AXL, BCL2, CA1, CSNK2A1, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1 5.50206
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, PTGES, TBXAS1 5.48592
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, INSR, KDR, PPARA, SMAD3, SRC, TEK, TYR 5.4559
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, AXL, BCL2, CYP1B1, EGFR, F10, F3, FLT3, GPR35, GRM1, HSPA1A, INSR, KDR, MET, PTPN1, SRC, TEK, XDH 5.44776
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.42882
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ALOX15, AXL, BCL2, CA2, CA7, CDK6, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, F3, GPR35, GRIK5, GRM5, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, MTNR1B, PPARA, PTPN1, SMAD3, SRC, TEK, TRPV1 5.34154
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, F10, F3, FLT3, GPR35, GRM1, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PTPN1, SRC, TEK, XDH 5.3122
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, MMP9, PTGES, SRC 5.22358
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 5.21679
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRB, F10, F3, FABP4, GRM1, GRM5, GRM8, HSD11B2, HSD17B2, IGF1R, INSR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, SMAD3, SRC, TEK, TNKS2, TRPV1, TYR 5.15155
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, GRIK5, GRM5, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, SMAD3, SRC, TRPV1 5.1191
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, BCL2, CDC25B, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MMP9, MTNR1A, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 5.10551
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ALOX15, BCL2, CDC25B, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MMP9, MTNR1A, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 5.04066
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GRIK5, HCAR2, HSPA1A, IGF1R, KDR, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, TRPV1, XDH 5.02992
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.02992
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, ALOX15, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESRRA, F10, F3, FABP4, FLT3, GPR35, GRM1, HSPA1A, INSR, KDR, MET, MMP12, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 4.94807
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 4.86578
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MTNR1B 4.77226
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GBA2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MAOA, MET, MMP1, MMP2, NQO2, NUAK1, PIM1, PPARA, PTGES, PTPN1, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TYR, XDH 4.73699
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, AXL, BCL2, CDK6, CYP1A1, CYP1B1, EGFR, ESR1, FABP4, FLT3, GRIK5, GRM5, IGF1R, INSR, KDR, MMP2, SMAD3, SRC, TRPV1 4.69367
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, AXL, BCL2, CA12, CA2, CA7, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, GRIK5, GRM1, GRM5, INSR, MET, MTNR1B, SMAD3, SRC, TRPV1 4.54364
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, BCL2, CDK6, CYP19A1, CYP1B1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.47416
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, AXL, BCL2, CA1, CA2, CDK6, CSNK2A1, CYP1B1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, MMP2, MMP9, MTNR1A, MTNR1B, NUAK1, PIM1, PPARA, PTGES, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1 4.47416
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA, SLC1A1, TRPV1 4.45513
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 4.4089
[BP] GO:0048878 chemical homeostasis AKR1B1, BCL2, CA12, CA2, CA7, EGFR, ESR1, FABP3, FABP4, GPR35, GRIK5, GRM1, GRM5, INSR, MET, MTNR1B, SMAD3, TRPV1 4.36429
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 4.36429
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK 4.33164
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CDK6, EGFR, HCAR2, KDR, SRC, TNKS, TNKS2, TRPV1 4.33164
[BP] GO:0032787 None ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, PPARA, PTGES, TBXAS1 4.29846
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, EGFR, GRM1, GRM3, GRM5, GRM8 4.23245
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK 4.19762
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.16575
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.16239
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.12425
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ALOX15, BCL2, CDC25B, EGFR, ESRRB, FABP3, FLT3, GRM1, GRM5, INSR, KDR, MMP9, MTNR1A, PTPN1, SMAD3, SRC, TEK, XDH 4.12362
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ALOX15, BCL2, CDC25B, EGFR, ESRRB, FABP3, FLT3, GRM1, GRM5, INSR, KDR, MMP9, MTNR1A, PTPN1, SMAD3, SRC, TEK, XDH 4.12362
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, EGFR, ESR1, F3, FLT3, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, PIM1, TEK 4.11768
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.11768
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, BCL2, CDK6, CYP19A1, CYP1B1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.0918
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F10, F3, INSR, MET, SRC, TEK 4.07933
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, BCL2, CDK6, CYP19A1, CYP1B1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.07933
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, F10, F3, INSR, MET, SRC, TEK, XDH 4.05006
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 3.96845
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ALOX15, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, MTNR1A, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1, XDH 3.92536
[BP] GO:0030335 positive regulation of cell migration BCL2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.90762
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, GRIK5, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, PTPN1, SMAD3, SRC, TRPV1 3.90762
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, ALPL, AURKB, AXL, BCL2, CA2, CA6, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, F10, F3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HSD11B2, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, PPARA, PTGES, PTPN1, SMAD3, SRC, TEK, TRPV1, TYR 3.83943
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TNKS 3.831
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, EGFR, MMP2, MMP9, TEK 3.831
[BP] GO:2000147 positive regulation of cell motility BCL2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.7651
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, CA2, CA7, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8 3.755
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, CA2, CA7, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8 3.755
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK 3.68366
[BP] GO:0060078 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5, TRPV1 3.66321
[BP] GO:0051272 positive regulation of cellular component movement BCL2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.66202
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, EGFR, PPARA, SMAD3 3.616
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ALOX15, AURKB, BCL2, CDC25B, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, MTNR1A, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1, XDH 3.5342
[BP] GO:0040017 positive regulation of locomotion BCL2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.51829
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, F10, F3, FABP4, FLT3, GPR35, GRM1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP2, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 3.49027
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, BCL2, CA2, CYP1A1, EGFR, GRM1, HSD11B2, HSPA1A, MMP2, PPARA, SMAD3, SRC, TEK, TRPV1, TYR 3.47812
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.46326
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, EGFR, GRIK5, INSR, MAOA, SLC1A1, SMAD3, TRPV1 3.46015
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, GRM1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 3.45662
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SRC, TEK 3.43705
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, SMAD3, SRC, TEK 3.417
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.34521
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.34521
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, SMAD3, SRC, TEK 3.32385
[BP] GO:0010638 positive regulation of organelle organization ALOX15, AURKB, BCL2, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2 3.27305
[BP] GO:1901652 response to peptide AKR1B1, FABP3, GRM5, HSD11B2, IGF1R, INSR, PPARA, SRC, TEK, TRPV1 3.26035
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.26035
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, SRC, TEK, TNKS, XDH 3.25541
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, EGFR, HSPA1A, MAOA 3.22093
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ALOX15, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, MTNR1A, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1, XDH 3.22093
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FUT7, GBA2, HSPA1A, MAOA, MMP1, MMP12, MMP2, MMP9, SRC, XDH 3.21164
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, EGFR, ESR1, MTNR1A, MTNR1B, PPARA, SRC 3.12946
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, F3, FABP4, FLT3, GPR35, GRM1, GRM3, GRM5, HSPA1A, IGF1R, INSR, MET, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TRPV1, XDH 3.12946
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ALOX15, AXL, BCL2, CA2, CA7, CYP19A1, EGFR, GPR35, GRIK5, GRM5, HCAR2, HSPA1A, INSR, MMP12, MMP9, MTNR1B, PPARA, PTPN1, SMAD3, SRC, TRPV1 3.12547
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, AURKB, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, GRM1, GRM3, GRM5, HSPA1A, IGF1R, INSR, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 3.10265
[BP] GO:0080134 regulation of response to stress ADORA1, CDK6, CYP19A1, DUSP3, EGFR, ESR1, F3, FABP4, HSPA1A, IGF1R, MET, MMP12, MMP2, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 3.08148
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, PIM1, PPARA, PTGES, TBXAS1, TYR 3.07127
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, SMAD3, SRC, TEK 3.06245
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AXL, CDK6, CYP1B1, EGFR, ESR1, GRIK5, GRM5, IGF1R, INSR, MMP2, MMP9, SRC, TRPV1 3.05702
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTGES, PTPN1, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TRPV1, TYR, XDH 3.05331
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, CDK6, KDR, SMAD3, SRC, TEK 3.03553
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, ALPL, AXL, BCL2, CA2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, INSR, KDR, MMP9, PIM1, PPARA, SMAD3, SRC, TEK, TYR 3.03097
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.03097
[BP] GO:0010243 response to organonitrogen compound AKR1B1, EGFR, FABP3, FLT3, GRM5, HSD11B2, IGF1R, INSR, MMP2, PPARA, SRC, TEK, TRPV1, TYR 3.02956
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MAOA, MET, MMP1, MMP12, MMP2, MMP9, MTNR1A, MTNR1B, NQO2, NUAK1, PIM1, PPARA, PTGES, PTPN1, SLC1A1, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TRPV1, TYR, XDH 3.02171
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ALOX15, BCL2, CDK6, CYP19A1, DUSP3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 3.01256
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, BCL2, CDC25B, EGFR, ESRRB, FLT3, GRM1, GRM5, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH 3.00783
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, ALPL, AURKB, AXL, BCL2, CA2, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD17B2, INSR, KDR, MET, MMP2, MMP9, PIM1, PPARA, SMAD3, SRC, TEK, TNKS2, TYR 3.00592
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, SRC, TEK, TNKS, XDH 2.98111
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, BCL2, CDC25B, DUSP3, EGFR, ESRRB, FABP4, FLT3, GRM1, GRM5, IGF1R, INSR, KDR, MMP9, PPARA, PTPN1, SRC, TEK, XDH 2.95413
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 2.95413
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK 2.93398
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5 2.91421
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.91421
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, EGFR, INSR, SMAD3, TRPV1, XDH 2.88286
[BP] GO:0042391 None ADORA1, BCL2, GPR35, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC, TRPV1 2.84015
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MAOA, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTGES, PTPN1, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TRPV1, TYR, XDH 2.8346
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, AXL, BCL2, CA2, CDK6, CYP1B1, EGFR, ESR1, ESRRA, ESRRB, F3, GPR35, GRM1, HCAR2, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PIM1, SLC1A1, SMAD3, SRC, TEK, TNKS2, TRPV1, XDH 2.8346
[BP] GO:0016310 phosphorylation AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TNKS 2.82544
[BP] GO:0010038 response to metal ion ALOX15, BCL2, CA2, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGES 2.81869
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, EGFR, MMP9, SRC 2.81869
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, SRC 2.80809
[BP] GO:0019371 None CBR1, PTGES, TBXAS1 2.80809
[BP] GO:0010907 None ESRRB, INSR, PPARA, SRC 2.80809
[BP] GO:0060079 None ADORA1, GRIA2, GRIA4, GRIK5, TRPV1 2.79544
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CSNK2A1, CYP1B1, DUSP3, ESR1, FABP4, GPR35, GRM3, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TNKS 2.77963
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, AURKB, AXL, BCL2, ESR1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2 2.75995
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX15, BCL2, CYP19A1, CYP1A1, CYP1B1, GBA2, MAOA, TYR 2.74867
[BP] GO:1901698 response to nitrogen compound AKR1B1, EGFR, FABP3, FLT3, GRM5, HSD11B2, IGF1R, INSR, MMP2, PPARA, SRC, TEK, TRPV1, TYR 2.73627
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, EGFR, FLT3, GRM1, INSR, KDR, PTPN1, SRC, TEK, XDH 2.72009
[BP] GO:0007187 None ADORA1, GRM1, GRM3, GRM5, GRM8, MTNR1A, MTNR1B 2.707
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ALOX15, DUSP3, EGFR, FLT3, GRM1, IGF1R, INSR, KDR, PTPN1, SRC, TEK, XDH 2.7035
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPR35, GRM3, GRM8, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTGES, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1, XDH 2.69968
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, BCL2, CDC25B, EGFR, FLT3, GRM1, GRM5, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH 2.69429
[BP] GO:0009115 None AOX1, XDH 2.69429
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ALOX15, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 2.6897
[BP] GO:0043436 oxoacid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, PIM1, PPARA, PTGES, TBXAS1, TYR 2.68836
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, FLT3, GRM1, IGF1R, INSR, PTPN1, SRC 2.65581
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 2.65581
[BP] GO:0010810 regulation of cell-substrate adhesion ALOX15, BCL2, CDK6, KDR, SMAD3, SRC, TEK 2.65581
[BP] GO:0007193 None ADORA1, GRM1, GRM3, GRM5, GRM8 2.63346
[BP] GO:0044093 positive regulation of molecular function ADORA1, AURKB, BCL2, CDC25B, EGFR, ESR1, ESR2, F3, FLT3, GRM1, GRM5, HSPA1A, INSR, MET, MMP9, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 2.63339
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPR35, GRM3, GRM8, HCAR2, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTGES, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1, XDH 2.62628
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.62628
[BP] GO:0042493 response to drug AKR1B1, AXL, BCL2, CA9, CDK6, CYP1A1, CYP1B1, EGFR, FABP3, HSD11B2, KDR, SRC, TRPV1 2.62302
[BP] GO:0006082 organic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, PIM1, PPARA, PTGES, TBXAS1, TYR 2.61631
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 2.59262
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ALOX15, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, F3, FLT3, GRM1, GRM5, HSPA1A, INSR, KDR, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 2.58816
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 2.58554
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, GBA2 2.5566
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.53814
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, SMAD3, TRPV1 2.49869
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, SMAD3, TRPV1 2.49869
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CYP1A1, EGFR, ESR1, FLT3, MET, PIM1, SRC, TEK, TYR 2.4759
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, EGFR, F10, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK, TNKS 2.4759
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ALOX15, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, IGF1R, INSR, KDR, MMP9, PTPN1, SRC, TEK, XDH 2.4759
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PTGES 2.46605
[BP] GO:0007346 regulation of mitotic cell cycle AURKB, BCL2, CDC25B, CDK6, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, TNKS 2.45101
[BP] GO:0002009 morphogenesis of an epithelium BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.44086
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CDK6, CYP1B1, EGFR, KDR, SRC, TRPV1 2.44086
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.43034
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ALOX15, BCL2, CDC25B, EGFR, ESR1, F3, FLT3, GRM1, GRM5, HSPA1A, INSR, KDR, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 2.42171
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, KDR, SRC, TRPV1 2.41992
[BP] GO:0051240 positive regulation of multicellular organismal process AXL, BCL2, CA2, CYP1B1, EGFR, ESRRB, F3, HCAR2, HSPA1A, KDR, MET, MMP12, MMP9, PIM1, SLC1A1, SMAD3, SRC, TEK, TRPV1 2.41369
[BP] GO:0051338 regulation of transferase activity ADORA1, AURKB, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, IGF1R, INSR, PTPN1, SRC, TEK, TNKS 2.40205
[BP] GO:0050801 ion homeostasis BCL2, CA12, CA2, CA7, EGFR, ESR1, FABP3, GPR35, GRM1, GRM5, SMAD3, TRPV1 2.40205
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.38637
[BP] GO:0032845 None ADORA1, BCL2, SRC, TNKS, TNKS2, TRPV1 2.38637
[BP] GO:0001954 positive regulation of cell-matrix adhesion CDK6, KDR, SMAD3, TEK 2.37018
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, EGFR, IGF1R, INSR, SRC, TNKS, TNKS2 2.37018
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, EGFR, ESR1, FABP4, HSPA1A, MMP12, MMP2, PPARA, PTPN1, SMAD3, SRC, TEK 2.36959
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, BCL2, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, IGF1R, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, XDH 2.35412
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, INSR, SMAD3, TRPV1, XDH 2.34236
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, AURKB, BCL2, CDC25B, EGFR, ESR1, F3, FLT3, GRM1, GRM5, HSPA1A, INSR, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 2.34236
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, BCL2, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, IGF1R, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, XDH 2.34236
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.33352
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, EGFR, FLT3, GRM1, GRM5, INSR, PTPN1, SRC, TEK, TNKS 2.32724
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.32358
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, EGFR, FLT3, HSD11B2, SRC 2.31374
[BP] GO:0099566 None GRM1, GRM5 2.31374
[BP] GO:0046110 None AOX1, XDH 2.31374
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.31374
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, GRIA2, GRIA4, GRIK5, PPARA, SLC1A1, TRPV1 2.298
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.26202
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MMP9, PTPN1, SRC 2.25756
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, EGFR, FLT3, HSD11B2, SRC 2.24632
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, EGFR, HCAR2, TNKS, TNKS2 2.24408
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, BCL2, CDC25B, CYP19A1, EGFR, ESR1, ESRRB, HSD17B2, INSR, SRC 2.21155
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.1998
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, DUSP3, EGFR, ESR1, F10, F3, FLT3, FUT7, GBA2, HSPA1A, IGF1R, INSR, KDR, MAOA, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TYR, XDH 2.18705
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, SMAD3, TRPV1 2.16874
[BP] GO:0010676 None ESRRB, INSR, PPARA, SRC 2.16874
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 2.15424
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.1526
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.1526
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.1526
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.1526
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.14737
[BP] GO:0031399 regulation of protein modification process ADORA1, ALOX15, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PTPN1, SRC, TEK, XDH 2.14737
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR 2.13842
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, PTGES, SRC 2.12372
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.12372
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.12372
[BP] GO:0022414 reproductive process AKR1B1, ALPL, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, EGFR, ESR1, ESRRB, HSD11B2, HSD17B2, INSR, MMP2, MMP9, MTNR1A, SRC 2.12275
[BP] GO:0043549 regulation of kinase activity ADORA1, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, IGF1R, INSR, PTPN1, SRC, TEK 2.10504
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 2.10393
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DUSP3, ESR1, HSPA1A, IGF1R, MET, MMP9, PTPN1, SRC, XDH 2.10087
[BP] GO:0048732 gland development BCL2, CSNK2A1, CYP19A1, EGFR, INSR, SMAD3, TYR 2.0962
[BP] GO:0044236 multicellular organism metabolic process MMP1, MMP12, MMP2, MMP9, TRPV1 2.07529
[BP] GO:0010811 positive regulation of cell-substrate adhesion ALOX15, CDK6, KDR, SMAD3, TEK 2.07529
[BP] GO:0070213 None TNKS, TNKS2 2.07279
[BP] GO:0006145 None AOX1, XDH 2.07279
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.07279
[BP] GO:0050678 None CDK6, EGFR, F3, KDR, MMP12, SMAD3, TEK, XDH 2.07036
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.06595
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, MMP12, PPARA, SMAD3, TEK 2.06463
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.05586
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, INSR, SMAD3, TRPV1 2.05586
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.05522
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.05522
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.05522
[BP] GO:0007154 None ADORA1, AXL, BCL2, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, MTNR1B, SLC1A1, TEK, TRPV1 2.03282
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CYP1A1, EGFR, HSD11B2, SRC, TRPV1, TYR 2.01537
[BP] GO:0098771 inorganic ion homeostasis BCL2, CA12, CA2, CA7, EGFR, ESR1, GPR35, GRM1, GRM5, SMAD3, TRPV1 2.00909
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TNKS, TNKS2 2.00827
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.00426
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ALOX15, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, ESR1, F10, F3, FLT3, FUT7, GBA2, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSD11B2, HSD17B2, IGF1R, INSR, KDR, MAOA, MET, MPEG1, MTNR1A, MTNR1B, PTGES, PTPN1, SLC1A1, SRC, TBXAS1, TEK, TRPV1, TYR 4.36429
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX15, ALOX5, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ESR1, F10, F3, FLT3, FUT7, GBA2, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSD11B2, HSD17B2, IGF1R, INSR, KDR, MAOA, MET, MMP2, MTNR1A, MTNR1B, PIM1, PTGES, PTPN1, SLC1A1, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TRPV1, TYR 4.25662
[CC] GO:0098590 plasma membrane region ADORA1, CA2, CA4, CA9, EGFR, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, INSR, MET, SLC1A1, SRC, TEK, TRPV1 4.18061
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, AXL, CA4, F10, F3, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, SLC1A1, TEK, TRPV1 4.09683
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALOX15, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, EGFR, ESR1, F10, F3, FLT3, GBA2, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, MMP2, MTNR1A, MTNR1B, PIM1, PTPN1, SLC1A1, SMAD3, SRC, TEK, TRPV1 3.97569
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ALOX15, AXL, CA2, CA4, CA9, DUSP3, EGFR, F10, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, SLC1A1, SRC, TEK, TRPV1 3.78831
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 2.9741
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, AXL, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, SLC1A1, TEK, TRPV1 2.8346
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, GBA2, GRIA2, HSD11B1, HSD11B2, HSD17B2, PTGES, TBXAS1 2.80809
[CC] GO:0043235 receptor complex EGFR, GRIA2, GRIA4, GRIK5, GRM1, IGF1R, INSR, MTNR1A, SMAD3 2.79948
[CC] GO:0044432 endoplasmic reticulum part BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, F10, FLT3, GBA2, GRIA2, HSD11B1, HSD11B2, HSD17B2, PTGES, PTPN1, TBXAS1 2.79021
[CC] GO:0097060 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, TRPV1 2.40106
[CC] GO:0031233 None CA4, F10, F3 2.14737
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, PTPN1, SMAD3, TBXAS1, TNKS, TYR, XDH 16.6659
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 16.1897
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, F10, F3, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MAOA, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIM1, PTGES, PTPN1, SRC, TBXAS1, TEK, TNKS, TNKS2, TYR, XDH 11.033
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 9.8663
[MF] GO:0043167 ion binding ACHE, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIM1, PPARA, PTGES, PTPN1, SLC1A1, SMAD3, SRC, TBXAS1, TEK, TNKS, TNKS2, TRPV1, TYR, XDH 9.05174
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 8.62155
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, PPARA, TEK, TRPV1 8.15661
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NQO2, PPARA, PTPN1, SMAD3, TNKS 8.05596
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MAOA, NQO2, TBXAS1, TYR, XDH 8.05596
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.61943
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, CDK6, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, PPARA, TEK, TRPV1 7.52106
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, PPARA, TEK, TRPV1 7.18031
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1, XDH 6.97474
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, PPARA, SMAD3, TEK, TRPV1 6.95905
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.67703
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.11918
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 5.92568
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, AOX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, F10, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIM1, PPARA, PTPN1, SLC1A1, SMAD3, TBXAS1, TNKS, TNKS2, TRPV1, TYR, XDH 5.7651
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, TEK, TRPV1 5.69362
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, MTNR1A, MTNR1B, TEK, TRPV1 5.69362
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, AOX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, F10, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIM1, PPARA, PTPN1, SLC1A1, SMAD3, TBXAS1, TNKS, TNKS2, TRPV1, TYR, XDH 5.5443
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 5.43099
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 5.42882
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1, TYR 5.42882
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD11B2, HSD17B1, NQO2, PTGES, SRC, TBXAS1, XDH 5.02992
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 4.83183
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR, MTNR1A, NQO2 4.53732
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, SRC, TBXAS1 4.53028
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 4.48968
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, SRC, TBXAS1 4.33164
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIM1, PPARA, SRC, TEK, TRPV1 4.09609
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1, TYR 4.02486
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.72247
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 3.67241
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 3.53971
[MF] GO:0008289 lipid binding ALOX15, AXL, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, HSD11B2, HSD17B1, PPARA, TRPV1 3.51829
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1 3.42164
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA 3.39331
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.39331
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.07477
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.0482
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.03097
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC 3.01386
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 2.9875
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 2.95413
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 2.91362
[MF] GO:0032403 protein complex binding ACHE, ADORA1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC 2.86261
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6 2.766
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.69429
[MF] GO:0003845 None HSD11B1, HSD11B2 2.69429
[MF] GO:0008389 None CYP2A13, CYP2A6 2.69429
[MF] GO:0016301 kinase activity AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK 2.5782
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.40106
[MF] GO:0036094 small molecule binding ADORA1, AOX1, AURKB, AXL, CDK6, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIM1, SLC1A1, SRC, TEK, TRPV1, XDH 2.33067
[MF] GO:0008502 None MTNR1A, MTNR1B 2.31374
[MF] GO:0099583 None GRM1, GRM5 2.31374
[MF] GO:0005231 None GRIA2, GRIA4, GRIK5, TRPV1 2.2874
[MF] GO:0043168 anion binding ALOX15, AOX1, AURKB, AXL, CDK6, CSNK2A1, EGFR, F10, F3, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIM1, PTGES, SLC1A1, SRC, TEK, TRPV1, XDH 2.27068
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.1998
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.1998
[MF] GO:0019902 phosphatase binding BCL2, EGFR, MET, PPARA, PTPN1, SMAD3 2.13842
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.07279
[MF] GO:0004971 None GRIA2, GRIA4 2.07279
[MF] GO:0030594 None GRIA2, GRIA4, GRIK5, GRM1, GRM5 2.03773


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 17.3624
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 8.4639
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GRIA2, GPR35, GRIK5, TRPV1, GRM1, GRM3, GRM5, MTNR1A, MTNR1B, ADORA3, GRM8, ADORA1, GRIA4 8.0652
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 8.0996
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 7.4503
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, GRM1, EGFR, ESR2, HSPA1A 6.5123
Metabolic pathways_Homo sapiens_hsa01100 CBR1, MAOA, ALOX15, AKR1B1, TYR, GBA2, CYP19A1, HSD11B1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH, PTGES 6.0174
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, GRM1, GRIA4 6.153
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 6.1644
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 5.965
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, EGFR, IGF1R 4.4789
Pathways in cancer_Homo sapiens_hsa05200 CDK6, SMAD3, FLT3, MMP1, MMP2, BCL2, MMP9, MET, EGFR, IGF1R 4.0574
Tryptophan metabolism_Homo sapiens_hsa00380 MAOA, CYP1A2, CYP1A1, AOX1, CYP1B1 4.9642
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 4.9439
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, TBXAS1, PTGES 4.1011
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KDR, TEK, MET, EGFR, IGF1R 3.4547
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, INSR, GRM8, GRM1, EGFR 3.4547
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, BCL2, PIM1, CYP1B1, MMP9, MET, EGFR, CDC25B 3.4136
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, MMP2, BCL2, PIM1, F3 3.1959
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CDK6, INSR, KDR, BCL2, TEK, MET, EGFR, IGF1R 3.0591
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.0205
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, BCL2, TEK, EGFR, IGF1R 3.1766
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, EGFR, IGF1R 2.8256
Ras signaling pathway_Homo sapiens_hsa04014 INSR, KDR, TEK, MET, EGFR, IGF1R 2.6258
Hepatitis B_Homo sapiens_hsa05161 CDK6, SMAD3, SRC, BCL2, MMP9 2.6258
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, GRM1, EGFR, IGF1R 2.7962
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1 2.9069
Melanoma_Homo sapiens_hsa05218 CDK6, MET, EGFR, IGF1R 2.8256
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, MAOA, CYP1A2, AOX1 2.8413
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 2.8413
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, MTNR1A, MTNR1B, GRIA4 2.4289
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, GRM1, GRIA4 2.342
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, GRIA2, ADORA1, PPARA, GRIA4 2.1132
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, GRM1, EGFR 2.5411
Glioma_Homo sapiens_hsa05214 CDK6, EGFR, IGF1R 1.9527
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 1.9582
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, ADORA1 2.102
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1, IGF1R 2.0273
Pancreatic cancer_Homo sapiens_hsa05212 CDK6, SMAD3, EGFR 1.9527
Prostate cancer_Homo sapiens_hsa05215 BCL2, EGFR, IGF1R 1.6447
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, GRM1 1.9527
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.6192
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, MAOA, GRIA4 1.9527
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 1.6354
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 1.8834
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET, EGFR 1.9527
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2, MAOA 2.2465
Insulin resistance_Homo sapiens_hsa04931 PTPN1, INSR, PPARA 1.4628
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 1.9442
Serotonergic synapse_Homo sapiens_hsa04726 MAOA, ALOX5, ALOX15 1.4465
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2, HSPA1A 1.4006
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.3883
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, CDC25B, HSPA1A 1.2325
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, MAOA, GRIA4 1.3262
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1, HSPA1A 1.2796
Cell cycle_Homo sapiens_hsa04110 CDK6, SMAD3, CDC25B 1.3594
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, ESRRB, IGF1R 1.2375
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.2016
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1 1.1735
Calcium signaling pathway_Homo sapiens_hsa04020 GRM5, GRM1, EGFR 1.0487
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, INSR, ADORA1 1.1185
Tyrosine metabolism_Homo sapiens_hsa00350 MAOA, AOX1, TYR 2.6258
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2, HSPA1A 0.9551
HTLV-I infection_Homo sapiens_hsa05166 SMAD3 0.169
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.2409
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2473
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2561
Alcoholism_Homo sapiens_hsa05034 MAOA 0.254
Influenza A_Homo sapiens_hsa05164 HSPA1A 0.2561
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.247
Platelet activation_Homo sapiens_hsa04611 SRC, TBXAS1 0.7825
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.2923
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, BCL2 0.8359
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.2996
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 0.9151
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2, HSPA1A 0.6183
Apoptosis_Homo sapiens_hsa04210 BCL2 0.3142
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, TRPV1 0.9151
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.3252
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, EGFR 0.9706
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.8002
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.8002
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, EGFR 0.5053
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.6796
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.5875
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, IGF1R 0.7775
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, INSR 0.7256
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.7256
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.7445
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, SRC 0.5289
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, EGFR 0.6564
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 0.9367
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.7187
Axon guidance_Homo sapiens_hsa04360 MET 0.3397
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3473
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 0.9551
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.3525
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2 0.9743
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6, SMAD3 1.0802
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 0.9401
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.3787
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.0392
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.3949
Melanogenesis_Homo sapiens_hsa04916 TYR 0.402
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.402
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.402
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4113
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4106
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 1.0347
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.4233
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4259
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4259
Taste transduction_Homo sapiens_hsa04742 GRM1 0.4372
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.4362
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4249
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.4241
Peroxisome_Homo sapiens_hsa04146 XDH 0.4372
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.2
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6, EGFR 1.2325
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.2325
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.4579
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.4693
Colorectal cancer_Homo sapiens_hsa05210 SMAD3, BCL2 1.1928
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.4832
Bile secretion_Homo sapiens_hsa04976 CA2 0.4812
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.2149
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.4852
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.4984
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5007
Shigellosis_Homo sapiens_hsa05131 SRC 0.5007
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2, BCL2 1.2885
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3 0.5007
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2, INSR 1.4526
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.5467
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.5648
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.3594
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.4465
Malaria_Homo sapiens_hsa05144 MET 0.5805
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOA 0.5763
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.5857
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.5849
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.5849
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.5857
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.633
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 1.6447
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.5039
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.5948
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOA 0.634
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.6794
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.7518
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7187
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.8251
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.731
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 4.9642
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7585
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7518
Histidine metabolism_Homo sapiens_hsa00340 MAOA 0.7825
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOA 0.8983
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.8791
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.9551
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.2325


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)