Component: Illicium difengpi 地枫皮


Description of the Component

Component ID
TCMH447
Latin Name
Illicium difengpi
English Name
Difengpi anisetree
Chinese Pinyin Name
Di Feng Pi
中文名
地枫皮
TCM Properties
Warm,Slightly Pungent,Punkery
TCM Meridians
Bladder,Kidney
Therapeutic Class English
Therapeutic Class Chinese
Functions
relieve rheumatic conditions, and promote the flow of qi and relieve pain
Toxicity
Toxic
Geo-authentic habitats (道地产区)
NA
Reference
Chinese Pharmacopoeia (2015)
Barcode ID
AF163728
Barcode Source
GenBank

TCM Prescriptions with the Component

Prescription ID Prescription English Name Prescription Chinese Name
TCMF2963 An Yang Hu Gu Yao Wine 安阳虎骨药酒
TCMFx412 Feng Han Shuang Li Guai Tablet 风寒双离拐片
TCMFx3292 Feng Han Shuang Li Guai Tablets 风寒双离拐片
TCMFx3337 Feng Shi An Tai Tablets 风湿安泰片
TCMFx3365 Feng Shi Fu Yin Pills 风湿福音丸
TCMF3416 Feng Shi Guan Jie Yan Pills 风湿关节炎丸
TCMF3407 Feng Shi Guan Jie Yan Tablets 风湿关节炎片
TCMF3432 Feng Shi Wine 风湿酒
TCMF3548 Feng Shi Zhen Tong Pills 风湿镇痛丸
TCMF3598 Feng Tong Pills 风痛丸
TCMF3590 Feng Tong Tablets 风痛片
TCMF3117 Fu Gui Feng Shi Ointment 附桂风湿膏
TCMF3515 Gu Tong Pills 骨痛丸
TCMF4042 Huang Jin Bo Yao Wine 黄金波药酒
TCMF4818 Jia Wei Tian Me Capsules 加味天麻胶囊
TCMFx4069 Jin Qian Bai Hua She Yao Wine 金钱白花蛇药酒
TCMF4474 Jing Tong Ling Yao Wine 颈痛灵药酒
TCMF4557 Jiu Zhi Xi Xian Cao Yao Wine 九制豨莶草药酒
TCMF4514 Ming Mu Shang Qing Tablets 明目上清片
TCMFx4874 Qi She Zhui Feng Wine 蕲蛇追风酒
TCMF5117 Qu Feng Ointment 祛风膏
TCMF5513 Shan Yao Pills 山药丸
TCMF5573 Shu Feng Ding Tong Pills 疏风定痛丸
TCMF5440 Shu Jin Pills 舒筋丸
TCMF5446 Shu Jin Zhi Tong Ding 舒筋止痛酊
TCMF5478 Shu Luo Yang Gan Pills 舒络养肝丸
TCMF1418 Shufeng Dingtong Pills 疏风定痛丸
TCMF2577 Shufeng Dingtong Pills 疏风定痛丸
TCMF5355 Wan Nian Chun Wine 万年春酒
TCMF6171 Yao Tui Tong Pills 腰腿痛丸
TCMF6564 Yuan Du Han Bi Oral Liquid 鸢都寒痹液
TCMF6557 Yuan Du Han Bi Yao Jiu Liao 鸢都寒痹药酒料
TCMF6641 Zhui Feng Shu Jing Huo Xue Tablets 追风舒经活血片

Targeted Human Proteins by the Ingredient of Component

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT1 EHMT2 Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Transferase Q96KQ7
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT18 GAA Lysosomal alpha-glucosidase Hydrolase P10253
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT193 RELA Nuclear factor NF-kappa-B p65 subunit Transcription factor Q04206
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT248 CXCL8 Interleukin-8 Unclassified P10145
TCMT273 NR1H4 Bile acid receptor FXR Nuclear receptor Q96RI1
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT281 DPP4 Dipeptidyl peptidase IV Unclassified P27487
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT31 CYP2C19 Cytochrome P450 2C19 Oxidoreductase P33261
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT41 IDH1 Isocitrate dehydrogenase [NADP] cytoplasmic Oxidoreductase O75874
TCMT42 KMT2A Histone-lysine N-methyltransferase MLL Transferase Q03164
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT80 MAPK1 MAP kinase ERK2 Kinase P28482
TCMT81 ALOX12 Arachidonate 12-lipoxygenase Oxidoreductase P18054
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712


Targeted Pathogenic Microbes by the Ingredient of Component

Target ID Target Name
TCMT1121 Sialidase
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1183 Candida albicans SC5314
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1223 Staphylococcus epidermidis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1286 Bacillus cereus
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Ingredient Structrues

Ingredient ID: TCMC960
Formula: C10H12O

Ingredient ID: TCMC857
Formula: C10H16O

Ingredient ID: TCMC804
Formula: C30H48O3

Ingredient ID: TCMC801
Formula: C29H50O

Ingredient ID: TCMC752
Formula: C20H18O11

Ingredient ID: TCMC671
Formula: C10H16

Ingredient ID: TCMC473
Formula: C10H16O

Ingredient ID: TCMC304
Formula: C10H18O

Ingredient ID: TCMC284
Formula: C10H16

Ingredient ID: TCMC2815
Formula: C15H24

Ingredient ID: TCMC2698
Formula: C11H14O2

Ingredient ID: TCMC2550
Formula: C15H24

Ingredient ID: TCMC2541
Formula: C10H18O

Ingredient ID: TCMC2539
Formula: C10H16

Ingredient ID: TCMC2484
Formula: C10H18O

Ingredient ID: TCMC2404
Formula: C30H50

Ingredient ID: TCMC2354
Formula: C10H14O

Ingredient ID: TCMC2324
Formula: C10H16

Ingredient ID: TCMC2035
Formula: C10H10O2

Ingredient ID: TCMC1826
Formula: C9H10O3

Ingredient ID: TCMC1737
Formula: C10H18O

Ingredient ID: TCMC170
Formula: C10H14O

Ingredient ID: TCMC1608
Formula: C10H16

Ingredient ID: TCMC1578
Formula: C11H14O2

Ingredient ID: TCMC1534
Formula: C24H26O6

Ingredient ID: TCMC1523
Formula: C18H18O2

Ingredient ID: TCMC1515
Formula: C30H50O

Ingredient ID: TCMC1493
Formula: C10H18O

Ingredient ID: TCMC1492
Formula: C10H18O

Ingredient ID: TCMC1389
Formula: C10H12O2

Ingredient ID: TCMC1294
Formula: C15H18

Ingredient ID: TCMC1238
Formula: C10H18O

Ingredient ID: TCMC1159
Formula: C10H12O2

Ingredient ID: TCMC1157
Formula: C10H18O

Ingredient ID: TCMC1134
Formula: C10H12O

Ingredient ID: TCMC1040
Formula: C20H22O7

Properties

Ingredient ID Formulae Name MW AlogP MlogP XlogP # HBA # HBD PSA # Rotatable Bond # Ring # Heacy Atom Lipinski RO5 Violation
TCMC170 C10H14O (S)(+)Carvone 150.1 1.5954 2.45 1.756 1 0 17.07 3 1 11 0
TCMC284 C10H16 1-Methyl-4-Prop-1-En-2-Ylcyclohexene 136.13 2.1424 2.56 3.729 0 0 0 3 1 10 0
TCMC304 C10H18O 2-(4-Methylcyclohex-3-En-1-Yl)Propan-2-Ol 154.14 1.1223 2.45 2.369 1 1 20.23 5 1 11 0
TCMC473 C10H16O 4,7,7-Trimethylbicyclo[2.2.1]Heptan-3-One 152.12 0.9693 2.45 2.127 1 0 17.07 3 2 11 0
TCMC671 C10H16 Alpha-Pinene 136.13 1.5162 2.56 4.177 0 0 0 3 1 10 0
TCMC752 C20H18O11 Avicularin 434.08 -4.3814 2.45 -0.111 6 7 186.37 11 4 31 1
TCMC801 C29H50O Beta-Sitosterol 414.39 1.3 4.54 11.595 1 1 20.23 13 4 30 1
TCMC804 C30H48O3 Betulinic Acid 456.36 2.3495 4.43 9.407 3 2 57.53 10 5 33 1
TCMC857 C10H16O Camphor 152.12 0.9693 2.45 2.127 1 0 17.07 3 2 11 0
TCMC960 C10H12O Cuminaldehyde 148.09 0.3805 2.45 4.48 1 0 17.07 4 1 11 0
TCMC1040 C20H22O7 Diffractaic Acid 374.14 1.6732 2.89 3.925 3 2 102.29 14 2 27 0
TCMC1134 C10H12O Estragole 148.09 0.9769 2.45 3.658 0 0 9.23 4 1 11 0
TCMC1157 C10H18O Eucalyptol 154.14 1.3109 2.45 2.595 1 0 9.23 3 0 11 0
TCMC1159 C10H12O2 Eugenol 164.08 0.5166 2.34 2.484 0 1 29.46 5 1 12 0
TCMC1238 C10H18O Geraniol 154.14 2.3397 2.45 2.524 1 1 20.23 8 0 11 0
TCMC1294 C15H18 Guaiazulene 198.14 1.8569 3.11 7.984 0 0 0 5 2 15 1
TCMC1389 C10H12O2 Isoeugenol 164.08 0.3952 2.34 2.805 0 1 29.46 5 1 12 0
TCMC1492 C10H18O Linalool 154.14 2.4692 2.45 2.468 1 1 20.23 8 0 11 0
TCMC1493 C10H18O Linalool (+) 154.14 2.4692 2.45 2.468 1 1 20.23 8 0 11 0
TCMC1515 C30H50O Lupeol 426.39 3.2313 4.65 11.901 1 1 20.23 9 5 31 1
TCMC1523 C18H18O2 Magnolol 266.13 1.1368 3.22 5.446 0 2 40.46 7 2 20 1
TCMC1534 C24H26O6 Mangostin 410.17 1.9042 3.44 3.11 1 3 96.22 13 3 30 0
TCMC1578 C11H14O2 Methyleugenol 178.1 0.9251 2.45 3.003 0 0 18.46 6 1 13 0
TCMC1608 C10H16 Myrcene 136.13 3.0936 2.56 4.17 0 0 0 6 0 10 0
TCMC1737 C10H18O Nerol 154.14 2.3397 2.45 2.524 1 1 20.23 8 0 11 0
TCMC1826 C9H10O3 Paeonol 166.06 -0.766 2.12 1.32 1 1 46.53 5 1 12 0
TCMC2035 C10H10O2 Safrole 162.07 0.726 2.34 2.93 0 0 18.46 2 2 12 0
TCMC2324 C10H16 Limonene 136.13 2.1424 2.56 3.729 0 0 0 3 1 10 0
TCMC2354 C10H14O (4-Propan-2-Ylphenyl)Methanol 150.1 0.1242 2.45 3.809 1 1 20.23 5 1 11 0
TCMC2404 C30H50 Squalene 410.39 8.5524 4.76 11.482 0 0 0 23 0 30 2
TCMC2484 C10H18O Terpineol 154.14 1.1223 2.45 1.947 1 1 20.23 5 1 11 0
TCMC2539 C10H16 Gamma-Terpinene 136.13 2.4017 2.56 3.852 0 0 0 4 1 10 0
TCMC2541 C10H18O Alpha-Terpineol 154.14 1.1223 2.45 2.369 1 1 20.23 5 1 11 0
TCMC2550 C15H24 (+)-Germacrene D 204.19 2.7967 3.11 6.294 0 0 0 4 1 15 1
TCMC2698 C11H14O2 Methylisoeugenol 178.1 0.8037 2.45 3.324 0 0 18.46 6 1 13 0
TCMC2815 C15H24 Caryophyllene 204.19 3.2289 3.11 6.044 0 0 0 3 2 15 1

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1. General Information of the Component  
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3. Putative Targets  
4. Activity & References for Filtering Putative Targets  
5. Ingredient Data & Chemical Structure Information (Properties, InChI, InChIkey, SMILES, etc.)