TCM Prescription: Ming Mu Shang Qing Tablets



Prescription Description
Prescription IDTCMF4514
Pinyin NameMing Mu Shang Qing Pian
Chinese Name明目上清片
English NameMing Mu Shang Qing Tablets
Function Description暴风客热
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with IndicationLiver, Eye
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1080 Platycodon grandiflorum 桔梗 TCMH1080 ITSAJ4293-14
TCMH1966 Rehmannia glutinosa 熟地黄 TCMH1966 ITSAH4578-14
TCMH2086 Trichosanthes kirilowii 天花粉 TCMH2086 ITSAO4359-14
TCMH1931 Gypsum fibrosum 石膏 TCMH1931
TCMH1423 Ophiopogon japonicus 麦冬 TCMH1423 ITSAJ4140-14
TCMH2343 Scrophularia ningpoensis 玄参 TCMH2343 ITSAO4295-14
TCMH2641 Gardenia jasminoides 栀子 TCMH2641 ITSAJ4473-14
TCMH1024 Tribulus terrestris 蒺藜 TCMH1024 ITSAJ4258-14
TCMH1181 Chrysanthemum morifolium 菊花 TCMH1181 KX675020
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
TCMH243 Pericarpium citri reticulatae 陈皮 TCMH243
TCMH235 Periostracum cicadae 蝉蜕 TCMH235
TCMH258 Paeonia obovata 赤芍 TCMH258 GBVX7902-15
TCMH972 Coptis chinensis 黄连 TCMH972 ITSAO4469-14
TCMH2618 Citrus aurantium 枳壳 TCMH2618 ITSAA1279-14
TCMH1661 Rhizoma homalomenae occultae 千年健 TCMH1661
TCMH524 Eucommia ulmoides 杜仲 TCMH524 ITSAM1588-14
TCMH447 Illicium difengpi 地枫皮 TCMH447 AF163728
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT221 ABCB11 Bile salt export pump Transporter O95342
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT304 MMP14 Matrix metalloproteinase 14 Hydrolase P50281
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT355 CSNK1D Casein kinase I delta Kinase P48730
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT41 IDH1 Isocitrate dehydrogenase [NADP] cytoplasmic Oxidoreductase O75874
TCMT417 DYRK2 Dual-specificity tyrosine-phosphorylation regulated kinase 2 Kinase Q92630
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT458 HASPIN Serine/threonine-protein kinase haspin Kinase Q8TF76
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT473 PIM3 Serine/threonine-protein kinase PIM3 Kinase Q86V86
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT561 NT5E 5'-nucleotidase Hydrolase P21589
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT567 DNMT1 DNA (cytosine-5)-methyltransferase 1 Transferase P26358
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT636 POLA1 DNA polymerase alpha subunit Transferase P09884
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT751 DYRK1A Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kinase Q13627
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT763 DYRK3 Dual-specificity tyrosine-phosphorylation regulated kinase 3 Kinase O43781
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT807 SLC22A12 Solute carrier family 22 member 12 Transporter Q96S37
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT81 ALOX12 Arachidonate 12-lipoxygenase Oxidoreductase P18054
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT814 CLK1 Dual specificty protein kinase CLK1 Kinase P49759
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT829 NISCH Nischarin Unclassified Q9Y2I1
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT831 DYRK4 Dual specificity tyrosine-phosphorylation-regulated kinase 4 Kinase Q9NR20
TCMT832 DYRK1B Dual specificity tyrosine-phosphorylation-regulated kinase 1B Kinase Q9Y463
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT884 PHF8 Histone lysine demethylase PHF8 Oxidoreductase Q9UPP1
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718
TCMT965 KDM7A Lysine-specific demethylase 7 Oxidoreductase Q6ZMT4


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1183 Candida albicans SC5314
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1305 Salmonella enteritidis
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1354 Streptococcus mutans UA159
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1385 Candida shehatae
TCMT1390 Human herpesvirus 2 strain G
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1460 Mycobacterium intracellulare
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DRD1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HASPIN, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MAOA, MET, MMP1, MMP12, MMP2, MMP9, NISCH, NUAK1, PHF8, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 15.8111
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DRD1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HASPIN, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MAOA, MET, MMP1, MMP2, NUAK1, PHF8, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 11.8307
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CBR1, CDC25B, CDK6, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DRD1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HASPIN, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NISCH, NUAK1, PHF8, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 11.1606
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, GPR35, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, KIT, MAOA, MET, NISCH, POLA1, POLB, PPARA, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 10.8639
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CBR1, CDC25B, CDK6, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DRD1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HASPIN, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MAOA, MET, MMP1, MMP12, MMP2, MMP9, NISCH, NUAK1, PHF8, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 10.7754
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, CLK1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, SRC, TEK 10.6617
[BP] GO:0018212 peptidyl-tyrosine modification AXL, CLK1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, SRC, TEK 10.596
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MMP2, POLB, PPARA, RORC, SMAD3, SRC, TEK, TYR 9.98644
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, APP, AXL, BCL2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, EGFR, ESR1, ESRRA, FABP3, HSD11B2, HSD17B2, IGF1R, INSR, MMP2, MMP9, POLB, PPARA, RORC, SRC, TEK, TYR 9.87128
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CLK1, CSNK2A1, DRD1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TNKS 9.73811
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, ESR1, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KIT, MET, PPARA, TBXAS1 9.73811
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DRD1, DUSP3, DYRK1A, DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 9.42823
[BP] GO:0042221 response to chemical ABCB1, AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MMP2, MMP9, POLB, PPARA, RORC, SMAD3, SRC, TEK, TERT, TYR 9.39291
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ALOX12, APEX1, APP, BCL2, CDK6, CYP19A1, CYP1B1, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, NISCH, SMAD3, SRC, TEK, TERT 9.2634
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CBR1, CDC25B, CDK6, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DUSP3, DYRK1A, DYRK1B, DYRK3, EGFR, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD17B2, INSR, KDR, KIT, MET, MMP2, MMP9, PHF8, PIM1, POLB, PPARA, RORC, SMAD3, SRC, TEK, TERT, TNKS2, TOP2A, TYR 9.00436
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ALOX12, APEX1, APP, BCL2, CYP19A1, CYP1B1, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, NISCH, SMAD3, SRC, TEK, TERT 9.00436
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CLK1, CSNK2A1, DRD1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, POLB, PTPN1, SRC, TEK, TNKS, XDH 8.98325
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, ALOX12, APP, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, DNMT1, EGFR, ESR1, ESRRA, F3, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MMP12, MMP2, MMP9, NUAK1, PIM1, SMAD3, SRC, TEK, TERT, XDH 8.92665
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, EGFR, F10, F3, FLT3, GPR35, HSPA1A, INSR, KDR, KIT, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 8.85766
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, EGFR, F10, F3, FLT3, GPR35, HSPA1A, INSR, KDR, KIT, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 8.824
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ALOX12, APEX1, APP, BCL2, CDK6, CYP19A1, CYP1B1, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, NISCH, SMAD3, SRC, TEK, TERT 8.71821
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ALOX12, APEX1, APP, BCL2, CDK6, CYP19A1, CYP1B1, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, NISCH, SMAD3, SRC, TEK, TERT 8.71821
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APEX1, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DNMT1, DRD1, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, IGF1R, INSR, KIT, MMP2, PPARA, SMAD3, SRC, TEK 8.71821
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DRD1, DUSP3, DYRK1A, DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 8.59416
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CLK1, CSNK2A1, DRD1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, POLB, PTPN1, SRC, TEK, TNKS, XDH 8.57863
[BP] GO:0046777 protein autophosphorylation AURKB, CLK1, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, KIT, PIM1, SRC, TEK 8.28883
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 8.20255
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CLK1, CSNK2A1, DRD1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, F10, FLT3, HASPIN, IGF1R, INSR, KDR, KIT, MET, SRC, TEK, TNKS, TOP2A 8.11693
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CLK1, CSNK2A1, DRD1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TNKS 8.11693
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CLK1, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, DRD1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, F10, F3, FLT3, FUT7, GBA2, GLO1, HASPIN, HSPA1A, IGF1R, INSR, KDR, KIT, MAOA, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PHF8, PIM1, POLB, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TYR, XDH 8.01403
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DUSP3, DYRK1A, DYRK2, DYRK3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NISCH, NUAK1, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 7.99793
[BP] GO:0030335 positive regulation of cell migration ALOX12, APP, BCL2, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, SMAD3, SRC, TEK, TERT 7.88106
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FUT7, GBA2, GLO1, HSPA1A, NISCH, PIM1, PPARA, TBXAS1, TYR, XDH 7.88106
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 7.86764
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BACE1, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DUSP3, DYRK1A, DYRK2, DYRK3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NISCH, NUAK1, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 7.85516
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, ALOX12, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DYRK3, EGFR, ESR1, F3, FLT3, GLO1, HSPA1A, IGF1R, KDR, KIT, MET, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, XDH 7.73847
[BP] GO:2000147 positive regulation of cell motility ALOX12, APP, BCL2, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, SMAD3, SRC, TEK, TERT 7.69619
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, ALOX12, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DYRK3, EGFR, ESR1, F3, FLT3, GLO1, HSPA1A, IGF1R, KDR, KIT, MET, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, XDH 7.69619
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APEX1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, KIT, MMP9, SRC, TERT 7.64989
[BP] GO:0051272 positive regulation of cellular component movement ALOX12, APP, BCL2, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, SMAD3, SRC, TEK, TERT 7.53492
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, DYRK3, EGFR, GLO1, HSPA1A, IGF1R, KDR, KIT, MET, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TERT 7.53492
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, DYRK3, EGFR, GLO1, HSPA1A, IGF1R, KDR, KIT, MET, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, TERT 7.47843
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, DYRK1A, DYRK2, DYRK3, EGFR, ESR1, F10, F3, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP9, NUAK1, PTPN1, SRC, TEK, XDH 7.33898
[BP] GO:0040017 positive regulation of locomotion ALOX12, APP, BCL2, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, SMAD3, SRC, TEK, TERT 7.32667
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MMP2, MMP9, RORC, SMAD3, SRC, TERT 7.32141
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MAOA, PHF8, TBXAS1, TYR, XDH 7.26899
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, ESR1, ESRRA, FLT3, HSD11B2, RORC, SRC, TEK, TYR 7.25354
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, INSR, KDR, KIT, PHF8, POLB, PPARA, SMAD3, SRC, TEK, TYR 7.2332
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, F10, F3, FLT3, GPR35, HSPA1A, INSR, KDR, KIT, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 7.16171
[BP] GO:0009725 response to hormone AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, INSR, KIT, PPARA, SRC, TEK 7.12118
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DYRK2, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MMP2, MMP9, NUAK1, POLA1, POLB, PTPN1, RORC, SMAD3, SRC, TERT, TOP2A 7.10199
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA1, ADORA3, ALOX12, ALOX15, APEX1, APP, AXL, BCL2, CA2, CA7, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD1, DYRK2, EGFR, F10, F3, GPR35, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NISCH, PPARA, PTPN1, SMAD3, SRC, TEK, TERT 7.09873
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APP, AXL, BCL2, CA2, CDK6, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DUSP3, DYRK1A, DYRK1B, EGFR, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, INSR, KDR, KIT, MMP9, PHF8, PIM1, POLB, PPARA, RORC, SMAD3, SRC, TEK, TYR 7.00678
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA6, CA7, CA9 7.00239
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CA2, CA6, CA9, CDK6, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DYRK2, EGFR, ESR1, ESRRA, F10, F3, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MMP12, MMP2, MMP9, NUAK1, POLA1, POLB, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TOP2A, TYR 6.83587
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, ALOX12, APEX1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DYRK3, EGFR, ESR1, F3, FLT3, GLO1, HSPA1A, IGF1R, KDR, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A, XDH 6.55276
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ALOX15, APP, AURKB, BCL2, CDC25B, DNMT1, DRD1, DYRK1A, DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, PHF8, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 6.54362
[BP] GO:0048583 regulation of response to stimulus ABCB1, ADORA1, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD1, DUSP3, DYRK1A, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, F10, F3, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP2, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 6.5296
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, RORC, SRC, TYR 6.5296
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DRD1, DYRK1A, DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, PHF8, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 6.49302
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 6.47265
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, APEX1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DNMT1, DRD1, DUSP3, DYRK1A, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GPR35, HSPA1A, IGF1R, KDR, KIT, MET, MMP12, MMP9, NISCH, PHF8, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 6.47265
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DRD1, DYRK1A, DYRK1B, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, PHF8, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 6.45245
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, APEX1, APP, AXL, BCL2, CDK6, CYP1A1, CYP1B1, DNMT1, DRD1, EGFR, ESR1, FABP4, FLT3, IGF1R, INSR, KDR, KIT, MMP2, RORC, SMAD3, SRC 6.36887
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ALOX15, APP, AURKB, BCL2, CDC25B, CSNK2A1, DNMT1, DRD1, DYRK1A, DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, PHF8, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 6.18243
[BP] GO:0080134 regulation of response to stress ABCB1, ADORA1, ALOX12, APP, CDK6, CYP19A1, DUSP3, DYRK1A, DYRK3, EGFR, ESR1, F3, FABP4, HSPA1A, IGF1R, MET, MMP12, MMP2, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, TERT, XDH 6.18038
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, APEX1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DNMT1, DRD1, DUSP3, DYRK1A, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GPR35, HSPA1A, IGF1R, KDR, KIT, MET, MMP12, MMP9, NISCH, PHF8, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 6.16442
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, DYRK3, EGFR, GLO1, HSPA1A, IGF1R, KDR, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, TERT 6.15279
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 5.97752
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CYP1B1, EGFR, F10, F3, FLT3, GPR35, HSPA1A, INSR, KDR, KIT, MET, PTPN1, SRC, TEK, XDH 5.94011
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, ALOX12, BCL2, CDC25B, CDK6, CSNK2A1, EGFR, ESR1, F3, FLT3, IGF1R, INSR, KDR, KIT, MMP12, MMP2, MMP9, PIM1, TEK, TERT 5.9132
[BP] GO:0019369 arachidonic acid metabolic process ALOX12, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, TBXAS1 5.81234
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, GBA2, MAOA, TYR 5.65918
[BP] GO:0044267 cellular protein metabolic process ALPL, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CLK1, CSNK2A1, DRD1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, F10, FLT3, FUT7, HASPIN, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP2, NUAK1, PHF8, PIM1, POLB, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 5.65109
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, ALOX15, APP, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESRRA, F10, F3, FABP4, FLT3, GPR35, HSPA1A, INSR, KDR, KIT, MET, MMP12, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 5.65109
[BP] GO:0019538 protein metabolic process ACHE, ALPL, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CLK1, CSNK2A1, DRD1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, F10, F3, FLT3, FUT7, HASPIN, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PHF8, PIM1, POLB, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 5.57949
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, ALOX12, APEX1, APP, AXL, BCL2, CA12, CA2, CA7, DRD1, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, INSR, MET, POLA1, POLB, SMAD3, SRC, TERT 5.49101
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.46874
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ALOX12, ALOX15, BCL2, CDK6, CYP19A1, DRD1, DUSP3, DYRK1A, DYRK3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC, TEK, TERT, XDH 5.43227
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, TBXAS1 5.38949
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, DYRK1A, DYRK2, DYRK3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 5.35802
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX12, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, FABP3, FABP4, FUT7, GBA2, KIT, MET, PPARA, TBXAS1 5.35802
[BP] GO:0043412 macromolecule modification ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CLK1, CSNK2A1, DNMT1, DRD1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, F10, FLT3, FUT7, HASPIN, IGF1R, INSR, KDR, KIT, MET, NUAK1, PHF8, PIM1, POLB, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 5.32268
[BP] GO:0006464 cellular protein modification process ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CLK1, CSNK2A1, DRD1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, F10, FLT3, FUT7, HASPIN, IGF1R, INSR, KDR, KIT, MET, NUAK1, PHF8, PIM1, POLB, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 5.28551
[BP] GO:0036211 protein modification process ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CLK1, CSNK2A1, DRD1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, F10, FLT3, FUT7, HASPIN, IGF1R, INSR, KDR, KIT, MET, NUAK1, PHF8, PIM1, POLB, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 5.28551
[BP] GO:0006690 icosanoid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, TBXAS1 5.17806
[BP] GO:0006807 nitrogen compound metabolic process ACHE, AKR1B1, AKR1B10, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CLK1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DRD1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FLT3, FUT7, GBA2, GLO1, HASPIN, HSPA1A, IGF1R, INSR, KDR, KIT, MAOA, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PHF8, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 5.16357
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, DRD1, EGFR, HSD11B2, HSPA1A, KIT, MMP2, POLB, PPARA, SMAD3, SRC, TEK, TERT, TYR 5.10496
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F10, F3, INSR, KIT, MET, SRC, TEK 5.07657
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 5.07159
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, APP, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, DRD1, DUSP3, EGFR, ESR1, ESRRB, F10, F3, FABP4, HSD11B2, HSD17B2, IGF1R, INSR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TNKS2, TYR 5.02824
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, F10, F3, INSR, KIT, MET, SRC, TEK, XDH 4.93798
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AURKB, BCL2, CLK1, CYP1A1, EGFR, ESR1, FLT3, KIT, MET, PIM1, POLA1, SRC, TEK, TYR 4.89453
[BP] GO:0007346 regulation of mitotic cell cycle APEX1, APP, AURKB, BCL2, CDC25B, CDK6, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, TERT, TNKS, TOP2A 4.85277
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DYRK1A, EGFR, ESR1, KIT, PPARA, RORC, SRC, TOP2A 4.73945
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, POLB, PPARA, SMAD3, SRC, TEK, TERT 4.65273
[BP] GO:0065007 biological regulation ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CDK6, CHRM2, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DRD1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GLO1, GPR35, HASPIN, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MAOA, MET, MMP1, MMP12, MMP2, MMP9, NISCH, NUAK1, PHF8, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 4.45036
[BP] GO:0009987 cellular process ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CHRM2, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DRD1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GPR35, HASPIN, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MAOA, MET, MMP1, MMP12, MMP2, MMP9, NISCH, NUAK1, PHF8, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 4.35645
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process APP, AURKB, DNMT1, DRD1, DYRK1B, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, IGF1R, INSR, MET, MMP12, PHF8, PPARA, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A 4.32049
[BP] GO:0010038 response to metal ion ALOX15, APP, BCL2, CA2, CYP1A1, CYP1A2, EGFR, FABP4, KIT, MMP9, TERT 4.26636
[BP] GO:0042493 response to drug ABCB1, AKR1B1, APEX1, AXL, BCL2, CA9, CDK6, CYP1A1, CYP1B1, DRD1, EGFR, FABP3, HSD11B2, KDR, POLB, SRC 4.25322
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, HASPIN, TERT, TNKS, TNKS2 4.25322
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.19743
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, SMAD3, SRC, TEK, TERT 4.18605
[BP] GO:0010907 None DYRK2, ESRRB, INSR, PPARA, SRC 4.15515
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX12, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, TBXAS1 4.13677
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, APP, AXL, CDK6, CYP1B1, DNMT1, DRD1, EGFR, ESR1, IGF1R, INSR, MMP2, MMP9, RORC, SRC 4.13496
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, BCL2, DRD1, DUSP3, DYRK1A, DYRK3, EGFR, ESR1, ESR2, GPR35, HSPA1A, IGF1R, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, TERT, XDH 4.13457
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AURKB, AXL, BCL2, DNMT1, ESR1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2 4.12861
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, BCL2, DRD1, DUSP3, DYRK1A, DYRK3, EGFR, ESR1, ESR2, GPR35, HSPA1A, IGF1R, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, TERT, XDH 4.11828
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, APP, DNMT1, DRD1, EGFR, FABP3, FLT3, HSD11B2, IGF1R, INSR, MMP2, PPARA, SRC, TEK, TYR 4.09335
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, SMAD3, SRC, TEK, TERT 4.08842
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, MMP2, MMP9, PTPN1, SRC, TEK 4.01797
[BP] GO:1901568 fatty acid derivative metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, TBXAS1 3.97843
[BP] GO:0009891 positive regulation of biosynthetic process APP, AURKB, DRD1, DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, INSR, KDR, MET, MMP12, PHF8, PPARA, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A 3.97843
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC 3.94322
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CDK6, CLK1, CSNK2A1, CYP1A2, CYP1B1, DNMT1, DRD1, DUSP3, DYRK1A, DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, GLO1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NUAK1, PHF8, PIM1, POLA1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 3.94249
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, EGFR, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.94064
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, APP, CYP1A1, CYP1B1, DRD1, EGFR, ESR1, FLT3, RORC, SRC 3.92621
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, DRD1, EGFR, ESRRB, FABP3, FLT3, INSR, KDR, KIT, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 3.92461
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, DRD1, EGFR, ESRRB, FABP3, FLT3, INSR, KDR, KIT, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 3.92461
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, EGFR, MMP2, MMP9, TEK 3.80297
[BP] GO:0010638 positive regulation of organelle organization ALOX15, AURKB, BCL2, DNMT1, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2 3.79257
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, EGFR, HSPA1A, MAOA 3.78161
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, DRD1, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, KIT, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 3.75651
[BP] GO:0006631 fatty acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, TBXAS1 3.73047
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CDK6, CLK1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DUSP3, DYRK1A, DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NUAK1, PHF8, PIM1, POLA1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 3.73007
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, APP, DNMT1, DRD1, EGFR, FABP3, FLT3, HSD11B2, IGF1R, INSR, MMP2, PPARA, SRC, TEK, TYR 3.71277
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, DRD1, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, KIT, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 3.7083
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CLK1, CSNK2A1, CYP1A1, CYP1B1, DNMT1, DRD1, DUSP3, DYRK1A, DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NUAK1, PHF8, PIM1, POLA1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 3.7083
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, BACE1, CA2, CA7, DRD1, EGFR, KIT, NISCH 3.68731
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, BACE1, CA2, CA7, DRD1, EGFR, KIT, NISCH 3.68731
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, MMP9, SRC 3.66333
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC, TEK 3.66147
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, RORC, SRC 3.65182
[BP] GO:0018107 peptidyl-threonine phosphorylation BCL2, CLK1, CSNK2A1, DYRK1A, HASPIN, TNKS 3.64368
[BP] GO:2001300 lipoxin metabolic process ALOX12, ALOX15, ALOX5 3.61565
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AURKB, DRD1, DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, INSR, MET, MMP12, PHF8, PPARA, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A 3.61459
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, EGFR, PPARA, SMAD3 3.58777
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process APP, AURKB, DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, IGF1R, INSR, KDR, MET, MMP12, PHF8, PPARA, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A 3.57588
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.57407
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CDK6, DRD1, EGFR, KDR, SRC, TNKS, TNKS2 3.53287
[BP] GO:0032787 None ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GBA2, GLO1, PPARA, TBXAS1 3.50195
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.49763
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 3.49681
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CLK1, CSNK2A1, CYP1B1, DNMT1, DRD1, DUSP3, DYRK1A, DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NUAK1, PHF8, PIM1, POLA1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 3.49274
[BP] GO:0018210 peptidyl-threonine modification BCL2, CLK1, CSNK2A1, DYRK1A, HASPIN, TNKS 3.46014
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CYP1A1, CYP1B1, DRD1, KDR, POLB, SRC 3.45104
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, APP, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, DYRK2, EGFR, HSD11B2, HSPA1A, KIT, MMP2, MMP9, NUAK1, POLA1, POLB, PPARA, PTPN1, SMAD3, SRC, TEK, TERT, TOP2A 3.44096
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, BACE1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, GBA2, HSPA1A, MAOA, MMP1, MMP12, MMP2, MMP9, SRC, XDH 3.42535
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK 3.41839
[BP] GO:0048869 cellular developmental process ACHE, ALPL, APP, AXL, BCL2, CBR1, CDC25B, CDK6, CYP1A1, DRD1, DYRK3, EGFR, ESR1, ESRRB, FABP4, FLT3, FUT7, GBA2, GLO1, KDR, KIT, MET, MMP2, MMP9, RORC, SMAD3, SRC, TEK, TERT, TOP2A 3.38203
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 3.36981
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APEX1, APP, DNMT1, DRD1, EGFR, ESR1, FLT3, IGF1R, INSR, KIT, MMP2, SMAD3, SRC 3.35844
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, ALOX15, APEX1, APP, AURKB, BCL2, CA9, CDC25B, CLK1, CSNK2A1, CYP1B1, DNMT1, DRD1, DUSP3, DYRK1A, DYRK1B, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, MMP9, NUAK1, PHF8, PIM1, POLA1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 3.31678
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.31678
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, FABP3, PPARA 3.31678
[BP] GO:0010676 None DYRK2, ESRRB, INSR, PPARA, SRC 3.31678
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, DRD1, EGFR, ESR1, ESRRB, HSD11B2, HSD17B2, INSR, KIT, MMP2, MMP9, SRC, TOP2A 3.31188
[BP] GO:0044093 positive regulation of molecular function ABCB1, ADORA1, APP, AURKB, BCL2, CDC25B, EGFR, ESR1, ESR2, F3, FLT3, HSPA1A, INSR, KIT, MET, MMP9, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, XDH 3.28121
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, APP, AXL, BCL2, CYP1B1, EGFR, HSPA1A, MMP9, SRC 3.27577
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, MET, MMP9, PPARA, SMAD3, SRC, TERT, TNKS 3.27577
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, APP, EGFR, FLT3, INSR, KDR, KIT, PTPN1, SRC, TEK, XDH 3.27294
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, CSNK2A1, DNMT1, DYRK1A, EGFR, ESR1, F3, FLT3, HSPA1A, INSR, KDR, KIT, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 3.2698
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KIT, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, XDH 3.26758
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, GBA2 3.26758
[BP] GO:0045931 positive regulation of mitotic cell cycle APEX1, APP, CDC25B, CYP1A1, DUSP3, INSR, TERT 3.26351
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT 3.2371
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DUSP3, DYRK1A, DYRK3, ESR1, HSPA1A, IGF1R, MET, MMP9, PTPN1, SRC, XDH 3.23302
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, APP, BCL2, CDC25B, DRD1, DUSP3, EGFR, ESRRB, FABP4, FLT3, IGF1R, INSR, KDR, KIT, MMP9, PPARA, PTPN1, SRC, TEK, XDH 3.22676
[BP] GO:1901652 response to peptide AKR1B1, APEX1, APP, FABP3, HSD11B2, IGF1R, INSR, PPARA, SRC, TEK 3.22676
[BP] GO:0065009 regulation of molecular function ABCB1, ADORA1, ADORA3, APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, DRD1, DUSP3, EGFR, ESR1, ESR2, F3, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, KIT, MET, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, XDH 3.22165
[BP] GO:0010906 None DYRK2, ESRRB, INSR, PPARA, RORC, SRC 3.21811
[BP] GO:0031399 regulation of protein modification process ADORA1, ALOX15, APP, BCL2, CDC25B, DNMT1, DRD1, DUSP3, DYRK1A, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MMP9, NUAK1, PTPN1, SRC, TEK, XDH 3.20321
[BP] GO:0046686 response to cadmium ion CYP1A2, EGFR, KIT, MMP9, TERT 3.1945
[BP] GO:0051128 regulation of cellular component organization ALOX12, ALOX15, APP, AURKB, AXL, BCL2, CSNK2A1, DNMT1, EGFR, ESR1, ESR2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP9, PHF8, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 3.19098
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ALOX15, APP, DUSP3, EGFR, FLT3, IGF1R, INSR, KDR, KIT, PTPN1, SRC, TEK, XDH 3.17108
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CDK6, CYP1B1, DRD1, EGFR, KDR, SRC 3.14131
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, DNMT1, EGFR, IGF1R, INSR, SRC, TNKS, TNKS2 3.13924
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, DNMT1, DYRK1A, EGFR, ESR1, F3, FLT3, HSPA1A, INSR, KDR, KIT, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 3.12945
[BP] GO:0051726 regulation of cell cycle APEX1, APP, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, SRC, TERT, TNKS, TOP2A 3.11598
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, APP, AXL, BCL2, CA1, CA2, CDK6, CHRM2, CSNK2A1, CYP1B1, DNMT1, DRD1, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, HASPIN, IGF1R, INSR, KDR, KIT, MET, MMP2, MMP9, NISCH, NUAK1, PIM1, POLB, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2 3.11431
[BP] GO:0070988 demethylation APEX1, CYP1A1, CYP1A2, CYP3A4, PHF8 3.10169
[BP] GO:0072593 reactive oxygen species metabolic process ALOX12, BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR 3.09116
[BP] GO:0048878 chemical homeostasis AKR1B1, ALOX12, APP, BCL2, CA12, CA2, CA7, DRD1, EGFR, ESR1, FABP3, FABP4, GPR35, INSR, MET, SMAD3 3.09065
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, CDK6, KDR, SMAD3, SRC, TEK 3.07023
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.04425
[BP] GO:0045787 positive regulation of cell cycle APEX1, APP, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, INSR, SRC, TERT 3.03435
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, KIT, SRC, TEK 2.98901
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX12, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2 2.98897
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR 2.98897
[BP] GO:0080135 regulation of cellular response to stress APP, CDK6, DUSP3, DYRK1A, DYRK3, EGFR, HSPA1A, IGF1R, MET, NUAK1, PTPN1, TERT, XDH 2.98897
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7 2.98897
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.98897
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, SRC 2.97065
[BP] GO:0018105 peptidyl-serine phosphorylation AURKB, BCL2, CLK1, DRD1, DYRK1A, SRC, TNKS 2.93848
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ADORA1, ALOX15, APP, AXL, BCL2, CA2, CA7, CYP19A1, DRD1, DYRK2, EGFR, GPR35, HSPA1A, INSR, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC, TERT 2.91266
[BP] GO:2001251 None DNMT1, PHF8, SRC, TNKS, TNKS2, TOP2A 2.91107
[BP] GO:0048534 hematopoietic or lymphoid organ development BCL2, FLT3, KDR, KIT, POLB, TEK, TYR 2.91107
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 2.91107
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, NISCH 2.89577
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, APP, BCL2, CDC25B, EGFR, ESRRB, FLT3, INSR, KDR, KIT, MMP9, PTPN1, SRC, TEK, XDH 2.87397
[BP] GO:0002320 lymphoid progenitor cell differentiation BCL2, FLT3, KIT 2.86856
[BP] GO:0090218 positive regulation of lipid kinase activity FLT3, KIT, SRC, TEK 2.84607
[BP] GO:0045913 None DYRK2, ESRRB, INSR, PPARA, SRC 2.83969
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, BCL2, CA1, CSNK2A1, DYRK2, EGFR, F3, FLT3, GPR35, IGF1R, INSR, KDR, KIT, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2 2.83226
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, APP, DNMT1, DRD1, EGFR, IGF1R, INSR, MMP2, SRC 2.83226
[BP] GO:0032101 regulation of response to external stimulus ADORA1, ALOX12, CYP19A1, DRD1, EGFR, ESR1, F3, FABP4, KDR, MET, MMP12, PPARA, SMAD3, TEK 2.80394
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ALOX12, APP, AXL, BCL2, CA2, CDK6, CHRM2, CYP1B1, EGFR, ESR1, ESRRA, ESRRB, F3, GPR35, HSPA1A, INSR, KDR, KIT, MET, MMP12, MMP9, PIM1, SMAD3, SRC, TEK, TERT, TNKS2, XDH 2.79559
[BP] GO:1904018 positive regulation of vasculature development ALOX12, CYP1B1, F3, KDR, KIT, TEK, TERT 2.79559
[BP] GO:0009115 None AOX1, XDH 2.76739
[BP] GO:0006286 base-excision repair, base-free sugar-phosphate removal APEX1, POLB 2.76739
[BP] GO:2001301 lipoxin biosynthetic process ALOX12, ALOX15 2.76739
[BP] GO:2001302 lipoxin A4 metabolic process ALOX12, ALOX15 2.76739
[BP] GO:2001303 lipoxin A4 biosynthetic process ALOX12, ALOX15 2.76739
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ALOX15, APP, BCL2, CDC25B, DRD1, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, KIT, MMP9, PTPN1, SRC, TEK, XDH 2.75779
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC, TEK 2.7447
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, DRD1, EGFR 2.73654
[BP] GO:0010675 None DYRK2, ESRRB, INSR, PPARA, RORC, SRC 2.73654
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, KIT, PPARA, SRC, TEK 2.69772
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, BCL2, CDC25B, CYP19A1, EGFR, ESR1, ESRRB, HSD17B2, INSR, KIT, SRC 2.69421
[BP] GO:0035556 intracellular signal transduction AKR1B1, AXL, BCL2, CYP1B1, DNMT1, DRD1, DYRK2, EGFR, HASPIN, IGF1R, INSR, KDR, KIT, MET, NISCH, NUAK1, POLB, PTPN1, SRC, TEK 2.68586
[BP] GO:0018209 peptidyl-serine modification AURKB, BCL2, CLK1, DRD1, DYRK1A, SRC, TNKS 2.68436
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.67407
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR 2.66696
[BP] GO:0051240 positive regulation of multicellular organismal process ALOX12, APP, AXL, BCL2, CA2, CYP1B1, EGFR, ESRRB, F3, HSPA1A, KDR, KIT, MET, MMP12, MMP9, PIM1, SMAD3, SRC, TEK, TERT 2.6648
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA7, CA9, CDC25B, CDK6, CHRM2, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DNMT1, DRD1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GLO1, GPR35, HASPIN, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NISCH, NUAK1, PHF8, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 2.64816
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, TERT 2.64816
[BP] GO:0010810 regulation of cell-substrate adhesion ALOX15, BCL2, CDK6, KDR, SMAD3, SRC, TEK 2.6333
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, DUSP3, ESR1, FABP4, GPR35, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TNKS 2.62324
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, APP, AURKB, BCL2, CDC25B, EGFR, ESR1, F3, FLT3, HSPA1A, INSR, KIT, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, XDH 2.60498
[BP] GO:0002521 leukocyte differentiation AXL, BCL2, FLT3, FUT7, GLO1, KIT, MMP9, RORC 2.60498
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, FLT3, IGF1R, INSR, KIT, PTPN1, SRC 2.60347
[BP] GO:0018958 None AKR1B1, BCL2, DRD1, MAOA, TYR 2.60347
[BP] GO:0010564 regulation of cell cycle process APEX1, APP, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, EGFR, HSPA1A, INSR, TERT, TNKS 2.60022
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.59061
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, APP, DNMT1, DRD1, EGFR, IGF1R, INSR, MMP2, SRC 2.59061
[BP] GO:0010628 positive regulation of gene expression APP, DNMT1, DRD1, DYRK1B, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, INSR, KIT, MET, MMP12, PHF8, PPARA, RORC, SMAD3, SRC, TERT, TNKS, TOP2A 2.57165
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, APP, BCL2, CDC25B, EGFR, FLT3, INSR, KDR, KIT, MMP9, PTPN1, SRC, TEK, XDH 2.55956
[BP] GO:0009968 negative regulation of signal transduction BCL2, DUSP3, DYRK1A, DYRK3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, TERT, XDH 2.55516
[BP] GO:0048608 reproductive structure development AXL, BCL2, CYP19A1, ESR1, HSD17B2, INSR, KIT, SRC 2.51331
[BP] GO:0050789 regulation of biological process ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA7, CA9, CDC25B, CDK6, CHRM2, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DNMT1, DRD1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GLO1, GPR35, HASPIN, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NISCH, NUAK1, PHF8, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A, XDH 2.50663
[BP] GO:0045725 None DYRK2, ESRRB, INSR 2.50509
[BP] GO:0070198 None TERT, TNKS, TNKS2 2.50509
[BP] GO:0051050 positive regulation of transport ABCB1, ACHE, ADORA1, APP, AXL, BCL2, CA2, CYP19A1, DRD1, EGFR, INSR, MMP12, SMAD3, SRC, TERT 2.47975
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, APP, DUSP3, EGFR, KDR, PTPN1, SRC, TEK 2.47511
[BP] GO:1901989 None APEX1, APP, CDC25B, CYP1A1, TERT 2.46612
[BP] GO:0043551 regulation of phosphatidylinositol 3-kinase activity FLT3, KIT, SRC, TEK 2.45869
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ALOX15, APP, BCL2, CDC25B, DNMT1, DYRK1A, EGFR, FLT3, INSR, KDR, KIT, MMP9, PTPN1, SRC, TEK, XDH 2.45869
[BP] GO:0019752 carboxylic acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GBA2, GLO1, PIM1, PPARA, TBXAS1, TYR 2.43766
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, FABP3, PPARA 2.4325
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.4325
[BP] GO:0070920 None EGFR, ESR1, TERT 2.4325
[BP] GO:0070875 None DYRK2, ESRRB, INSR 2.4325
[BP] GO:0019372 lipoxygenase pathway ALOX12, ALOX15, ALOX5 2.4325
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FLT3, KIT, PPARA, RORC, SRC, TEK 2.41741
[BP] GO:0002009 morphogenesis of an epithelium BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.40456
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, DRD1, KDR, SRC 2.39835
[BP] GO:0051254 None APP, DYRK1B, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, INSR, MET, MMP12, PHF8, PPARA, RORC, SMAD3, SRC, TERT, TNKS, TOP2A 2.39835
[BP] GO:0001954 positive regulation of cell-matrix adhesion CDK6, KDR, SMAD3, TEK 2.39717
[BP] GO:0098502 DNA dephosphorylation APEX1, POLB 2.37055
[BP] GO:0046110 None AOX1, XDH 2.37055
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.37055
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.36773
[BP] GO:0019219 regulation of nucleobase-containing compound metabolic process ADORA3, APEX1, APP, AURKB, CA9, CLK1, CSNK2A1, CYP1B1, DNMT1, DRD1, DYRK1A, DYRK1B, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP4, GLO1, HSPA1A, IGF1R, INSR, KIT, MET, MMP12, PHF8, PIM1, POLA1, PPARA, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A 2.33801
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.32264
[BP] GO:0030155 regulation of cell adhesion ALOX12, ALOX15, BCL2, CDK6, CYP1B1, DUSP3, KDR, NUAK1, PPARA, SMAD3, SRC, TEK 2.30679
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.29631
[BP] GO:0051704 multi-organism process APP, AXL, BCL2, CDK6, CHRM2, CYP1A1, DYRK1A, EGFR, HSD11B2, HSPA1A, INSR, KDR, MET, MMP1, MMP12, POLA1, SMAD3, SRC 2.2829
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, EGFR, FLT3, HSD11B2, SRC 2.27932
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KIT, PTPN1, SRC, TEK, TNKS 2.26564
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, EGFR, ESR1, FABP4, HSPA1A, MMP12, MMP2, PPARA, PTPN1, SMAD3, SRC, TEK 2.25406
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MMP9, PTPN1, SRC 2.25406
[BP] GO:0033554 cellular response to stress AKR1B1, ALOX15, APEX1, AXL, BCL2, CA2, CA9, CYP1B1, DYRK2, EGFR, HSPA1A, MMP9, NUAK1, POLA1, POLB, PTPN1, SRC, TERT, TOP2A 2.25406
[BP] GO:0045766 positive regulation of angiogenesis ALOX12, CYP1B1, F3, KDR, TEK, TERT 2.23836
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.23302
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, EGFR, FLT3, HSD11B2, SRC 2.2253
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APEX1, APP, AURKB, BCL2, CSNK2A1, DNMT1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, FABP4, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, XDH 2.22151
[BP] GO:0014066 regulation of phosphatidylinositol 3-kinase signaling EGFR, FLT3, KDR, KIT, TEK 2.2174
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, EGFR, TNKS, TNKS2 2.20624
[BP] GO:0044089 positive regulation of cellular component biogenesis ALOX15, ESR1, HSPA1A, KDR, KIT, MET, MMP1, SMAD3, SRC, TEK 2.19726
[BP] GO:0045893 None APP, DYRK1B, EGFR, ESR1, ESR2, ESRRA, ESRRB, INSR, MET, MMP12, PHF8, PPARA, RORC, SMAD3, SRC, TERT, TNKS, TOP2A 2.19726
[BP] GO:1903508 None APP, DYRK1B, EGFR, ESR1, ESR2, ESRRA, ESRRB, INSR, MET, MMP12, PHF8, PPARA, RORC, SMAD3, SRC, TERT, TNKS, TOP2A 2.19726
[BP] GO:1902680 None APP, DYRK1B, EGFR, ESR1, ESR2, ESRRA, ESRRB, INSR, MET, MMP12, PHF8, PPARA, RORC, SMAD3, SRC, TERT, TNKS, TOP2A 2.19456
[BP] GO:0044260 cellular macromolecule metabolic process ACHE, ALPL, APEX1, APP, AURKB, AXL, BACE1, BCL2, CDC25B, CDK6, CLK1, CSNK2A1, DNMT1, DRD1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FLT3, FUT7, HASPIN, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP2, NUAK1, PHF8, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TOP2A 2.18889
[BP] GO:0043550 regulation of lipid kinase activity FLT3, KIT, SRC, TEK 2.18718
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ALOX15, APP, BCL2, CDC25B, CSNK2A1, DNMT1, DRD1, DUSP3, DYRK1A, EGFR, ESR1, F3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MMP9, NUAK1, PTPN1, SMAD3, SRC, TEK, XDH 2.18352
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.16497
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.16136
[BP] GO:0050730 None ADORA1, APP, EGFR, FLT3, KIT, PTPN1, SRC 2.16136
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.15435
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.15435
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.15435
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.15435
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX12, ALOX15, CYP19A1, CYP3A4, TYR 2.14351
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.13795
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.13795
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.12675
[BP] GO:0070213 None TNKS, TNKS2 2.12552
[BP] GO:0006145 None AOX1, XDH 2.12552
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.12552
[BP] GO:0008150 biological_process ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CHRM2, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DRD1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GPR35, HASPIN, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MAOA, MET, MMP1, MMP12, MMP2, MMP9, NISCH, NUAK1, PHF8, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 2.11422
[BP] GO:0060969 None ESR1, PHF8, TERT 2.08066
[BP] GO:0022612 gland morphogenesis BCL2, EGFR, POLB 2.08066
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.08066
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.08066
[BP] GO:0001101 response to acid chemical AKR1B1, DNMT1, EGFR, FABP3, HSD17B2, KDR, MMP2, SRC 2.08066
[BP] GO:0010811 positive regulation of cell-substrate adhesion ALOX15, CDK6, KDR, SMAD3, TEK 2.0779
[BP] GO:0043436 oxoacid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GBA2, GLO1, PIM1, PPARA, TBXAS1, TYR 2.0688
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.0688
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, EGFR, INSR, SMAD3, XDH 2.0688
[BP] GO:0048732 gland development BCL2, CSNK2A1, CYP19A1, EGFR, INSR, SMAD3, TYR 2.0688
[BP] GO:0010639 None DNMT1, HSPA1A, MET, PHF8, SRC, TNKS, TNKS2, TOP2A 2.0688
[BP] GO:0008406 gonad development BCL2, CYP19A1, ESR1, INSR, KIT 2.04737
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, MMP12, PPARA, SMAD3, TEK 2.04527
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.03364
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.03364
[BP] GO:0050678 None CDK6, EGFR, F3, KDR, MMP12, SMAD3, TEK, XDH 2.02187
[BP] GO:0033043 regulation of organelle organization ALOX15, AURKB, BCL2, DNMT1, HSPA1A, INSR, KDR, MET, MMP9, PHF8, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 2.02187
[BP] GO:1901342 regulation of vasculature development ALOX12, CYP1B1, F3, KDR, KIT, TEK, TERT, XDH 2.01404
[BP] GO:0006109 regulation of carbohydrate metabolic process DYRK2, ESRRB, INSR, PPARA, RORC, SRC 2.01062
[BP] GO:0006082 organic acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GBA2, GLO1, PIM1, PPARA, TBXAS1, TYR 2.00325
[BP] GO:0009889 regulation of biosynthetic process ADORA3, APEX1, APP, AURKB, BCL2, CA9, CSNK2A1, CYP1B1, DNMT1, DRD1, DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, PHF8, PIM1, POLA1, PPARA, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A 2.00242
[CC] GO:0043227 membrane-bounded organelle ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CA6, CBR1, CDK6, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DRD1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HASPIN, HSPA1A, IGF1R, INSR, KDR, KIT, MAOA, MMP12, MMP2, MMP9, NISCH, NUAK1, PHF8, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 5.2869
[CC] GO:0043226 organelle ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA2, CA4, CA6, CA9, CBR1, CDK6, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DRD1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HASPIN, HSPA1A, IGF1R, INSR, KDR, KIT, MAOA, MMP12, MMP2, MMP9, NISCH, NUAK1, PHF8, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 4.18677
[CC] GO:0043231 intracellular membrane-bounded organelle ACHE, ADORA1, AKR1B1, AKR1B10, APEX1, APP, AURKB, BACE1, BCL2, CA4, CDK6, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DRD1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, GLO1, HASPIN, HSPA1A, IGF1R, KDR, KIT, MAOA, MMP12, MMP2, NUAK1, PHF8, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 3.27858
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, APEX1, APP, AURKB, BACE1, BCL2, CA1, CA2, CA4, CA7, CBR1, CDC25B, CDK6, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DUSP3, DYRK2, DYRK3, EGFR, ESR1, ESR2, F10, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, KIT, MAOA, MMP2, MMP9, NISCH, PIM1, POLA1, PTPN1, SMAD3, SRC, TBXAS1, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 2.74873
[CC] GO:0005886 plasma membrane ABCB1, ACHE, ADORA1, ADORA3, ALOX12, ALOX15, ALPL, APP, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CHRM2, CSNK2A1, DRD1, EGFR, ESR1, F10, F3, FLT3, GBA2, GLO1, GPR35, IGF1R, INSR, KDR, KIT, MET, MMP2, NISCH, PIM1, PTPN1, SMAD3, SRC, TEK, TERT 2.68565
[CC] GO:0044432 endoplasmic reticulum part APP, BACE1, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, EGFR, F10, FLT3, GBA2, HSD11B1, HSD11B2, HSD17B2, PTPN1, TBXAS1 2.62158
[CC] GO:0005654 None AKR1B1, ALOX5, APEX1, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, DNMT1, DUSP3, DYRK1A, DYRK2, DYRK3, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, NUAK1, PHF8, PIM1, POLA1, POLB, PPARA, RORC, SMAD3, SRC, TERT, TNKS, TOP2A 2.38154
[CC] GO:0016020 membrane ABCB1, ACHE, ADORA1, ADORA3, ALOX12, ALOX15, ALOX5, ALPL, APP, AXL, BACE1, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, EGFR, ESR1, F10, F3, FLT3, FUT7, GBA2, GLO1, GPR35, HSD11B1, HSD11B2, HSD17B2, IGF1R, INSR, KDR, KIT, MAOA, MET, MMP2, NISCH, PHF8, PIM1, PTPN1, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TYR 2.36024
[CC] GO:0031233 None CA4, F10, F3 2.17947
[MF] GO:0003824 catalytic activity ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BACE1, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, F10, F3, FLT3, FUT7, GBA2, GLO1, HASPIN, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MAOA, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PHF8, PIM1, POLA1, POLB, PTPN1, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 19.7724
[MF] GO:0046914 transition metal ion binding ALOX12, ALOX15, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DYRK2, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, PHF8, PIM1, PPARA, PTPN1, RORC, SMAD3, TBXAS1, TNKS, TYR, XDH 19.2136
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CDK6, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DRD1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GLO1, HASPIN, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NISCH, NUAK1, PHF8, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 18.206
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 11.3558
[MF] GO:0004713 protein tyrosine kinase activity AXL, CLK1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, SRC, TEK 10.7754
[MF] GO:0043169 cation binding ACHE, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DRD1, DYRK2, DYRK3, ESR1, ESR2, ESRRA, ESRRB, F10, GLO1, KIT, MMP1, MMP12, MMP2, MMP9, NUAK1, PHF8, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SMAD3, TBXAS1, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 9.87128
[MF] GO:0046872 metal ion binding ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DYRK2, DYRK3, ESR1, ESR2, ESRRA, ESRRB, F10, GLO1, KIT, MMP1, MMP12, MMP2, MMP9, NUAK1, PHF8, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SMAD3, TBXAS1, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 9.05617
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CDK6, CHRM2, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, PPARA, SRC, TEK, TOP2A 9.00436
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, POLB 8.75561
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MAOA, PHF8, TBXAS1, TYR, XDH 8.71821
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK 8.71821
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA6, CA7, CA9, DNMT1, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, PHF8, PPARA, PTPN1, RORC, SMAD3, TNKS 8.71821
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, TEK 8.12561
[MF] GO:0005506 iron ion binding ALOX12, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, PHF8, TBXAS1, XDH 8.12561
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, POLA1, POLB, SRC, TEK, TERT 7.77325
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK 7.4694
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, TEK 7.32557
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 7.1875
[MF] GO:0016301 kinase activity AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK 6.86463
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, GLO1, POLB 6.48798
[MF] GO:0005496 steroid binding CYP3A4, ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, RORC 5.74932
[MF] GO:0036094 small molecule binding ABCB1, ADORA1, AOX1, AURKB, AXL, CDK6, CLK1, CSNK2A1, DNMT1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FABP3, FABP4, FLT3, HASPIN, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, POLA1, SRC, TEK, TOP2A, XDH 5.67285
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, BACE1, CDC25B, CDK6, CLK1, CSNK2A1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, F10, F3, FLT3, HASPIN, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PHF8, PIM1, PTPN1, SRC, TEK 5.43368
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 5.43368
[MF] GO:0000166 nucleotide binding ABCB1, AOX1, AURKB, AXL, CDK6, CLK1, CSNK2A1, DNMT1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, POLA1, SRC, TEK, TOP2A, XDH 5.43227
[MF] GO:1901265 nucleoside phosphate binding ABCB1, AOX1, AURKB, AXL, CDK6, CLK1, CSNK2A1, DNMT1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, POLA1, SRC, TEK, TOP2A, XDH 5.43168
[MF] GO:0043168 anion binding ABCB1, ALOX15, AOX1, APP, AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, F10, F3, FABP3, FABP4, FLT3, HASPIN, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NISCH, NUAK1, PIM1, SRC, TEK, TOP2A, XDH 5.11546
[MF] GO:0004712 protein serine/threonine/tyrosine kinase activity AURKB, CLK1, DYRK1A, DYRK1B, DYRK2, DYRK3 5.07657
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR, KIT 4.96946
[MF] GO:0005524 ATP binding ABCB1, AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TOP2A 4.92581
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 4.9163
[MF] GO:0032559 adenyl ribonucleotide binding ABCB1, AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TOP2A 4.74867
[MF] GO:0008289 lipid binding ALOX15, AXL, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, HSD11B2, HSD17B1, NISCH, PPARA, RORC 4.71229
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.71192
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.71192
[MF] GO:0030554 adenyl nucleotide binding ABCB1, AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TOP2A 4.71192
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 4.6605
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TBXAS1, TYR 4.26506
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.25322
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, PHF8, TBXAS1, TYR 3.97843
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, APEX1, CSNK2A1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, NISCH, PIM1, PPARA, PTPN1, SMAD3, SRC 3.94595
[MF] GO:0032403 protein complex binding ACHE, ADORA1, APEX1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, NISCH, PPARA, PTPN1, SMAD3, SRC 3.88612
[MF] GO:0097159 organic cyclic compound binding ABCB1, ADORA1, AOX1, APEX1, APP, AURKB, AXL, BCL2, CDK6, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DRD1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HASPIN, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, NUAK1, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TERT, TOP2A, XDH 3.75651
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, CHRM2, DRD1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, IGF1R, INSR, KDR, KIT, MET, PPARA, RORC, TEK 3.72342
[MF] GO:0004674 protein serine/threonine kinase activity AURKB, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, HASPIN, NUAK1, PIM1 3.7083
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.70766
[MF] GO:0097367 carbohydrate derivative binding ABCB1, ADORA1, APP, AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, POLA1, SRC, TEK, TOP2A 3.66295
[MF] GO:1901363 heterocyclic compound binding ABCB1, ADORA1, AOX1, APEX1, APP, AURKB, AXL, BCL2, CDK6, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HASPIN, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, NUAK1, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TERT, TOP2A, XDH 3.57882
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 3.57749
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, SRC, TBXAS1 3.53287
[MF] GO:0035639 purine ribonucleoside triphosphate binding ABCB1, AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TOP2A 3.50547
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HSD11B2, HSD17B1, POLA1, SRC, TBXAS1, XDH 3.47361
[MF] GO:0032555 purine ribonucleotide binding ABCB1, AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TOP2A 3.35824
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, SRC, TBXAS1 3.34999
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, CDK6, CHRM2, DRD1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, IGF1R, INSR, KDR, KIT, MET, PPARA, RORC, TEK 3.32011
[MF] GO:0017076 purine nucleotide binding ABCB1, AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TOP2A 3.31678
[MF] GO:0032553 ribonucleotide binding ABCB1, AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, SRC, TEK, TOP2A 3.31406
[MF] GO:0016740 transferase activity AURKB, AXL, CDK6, CLK1, CSNK2A1, DNMT1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, FUT7, HASPIN, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIM1, POLA1, POLB, SRC, TEK, TERT, TNKS, TNKS2 3.28537
[MF] GO:0019899 enzyme binding APP, AURKB, BACE1, BCL2, CDC25B, CYP1A1, CYP1A2, CYP3A4, DUSP3, EGFR, ESR1, ESR2, ESRRB, F3, HSPA1A, KIT, MET, POLA1, POLB, PPARA, PTPN1, SMAD3, SRC, TEK, TNKS2, TOP2A 3.19368
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.15148
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.11598
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, CHRM2, DRD1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, IGF1R, INSR, KDR, KIT, MET, PPARA, RORC, TEK 3.0572
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.04443
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, CHRM2, DRD1, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, IGF1R, INSR, KDR, KIT, MET, PPARA, RORC, SMAD3, TEK 2.95456
[MF] GO:0042802 identical protein binding ACHE, AOX1, APP, BCL2, CSNK2A1, DYRK1A, EGFR, ESR1, ESR2, FLT3, IGF1R, KDR, KIT, MET, MMP9, NISCH, SMAD3, TERT, TOP2A, TYR, XDH 2.7914
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.76739
[MF] GO:0003845 None HSD11B1, HSD11B2 2.76739
[MF] GO:0047977 hepoxilin-epoxide hydrolase activity ALOX12, ALOX15 2.76739
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR 2.44545
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.4295
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.37055
[MF] GO:0004052 arachidonate 12-lipoxygenase activity ALOX12, ALOX15 2.37055
[MF] GO:0051120 hepoxilin A3 synthase activity ALOX12, ALOX15 2.37055
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.17947
[MF] GO:0019902 phosphatase binding BCL2, EGFR, MET, PPARA, PTPN1, SMAD3 2.12552
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.12552
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.12552
[MF] GO:0051425 None APP, INSR 2.12552
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.12552
[MF] GO:0003674 molecular_function ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, APP, AURKB, AXL, BACE1, BCL2, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CHRM2, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DNMT1, DRD1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GPR35, HASPIN, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MAOA, MET, MMP1, MMP12, MMP2, MMP9, NISCH, NUAK1, PHF8, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TERT, TNKS, TNKS2, TOP2A, TYR, XDH 2.10127
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.04737


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA6, CA9, CA14 12.2526
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 8.4393
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 9.3537
Metabolic pathways_Homo sapiens_hsa01100 CBR1, DNMT1, MAOA, ALOX15, AKR1B1, ALOX12, TYR, CYP3A4, GBA2, CYP19A1, HSD11B1, POLA1, FUT7, AKR1B10, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 6.7038
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 7.1549
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, EGFR, ESR2, HSPA1A 5.0064
Pathways in cancer_Homo sapiens_hsa05200 CDK6, SMAD3, FLT3, MMP1, MMP2, KIT, BCL2, MMP9, MET, EGFR, IGF1R 4.5426
MicroRNAs in cancer_Homo sapiens_hsa05206 DNMT1, CDK6, ABCB1, BCL2, PIM1, CYP1B1, MMP9, MET, EGFR, CDC25B 4.7064
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 4.7064
Tryptophan metabolism_Homo sapiens_hsa00380 MAOA, CYP1A2, CYP1A1, AOX1, CYP1B1 4.7064
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CDK6, INSR, KIT, KDR, BCL2, TEK, MET, EGFR, IGF1R 4.3242
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, EGFR, IGF1R 4.2929
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 4.7064
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KIT, KDR, TEK, MET, EGFR, IGF1R 4.1991
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 4.5426
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KIT, KDR, MET, EGFR, IGF1R, HSPA1A 3.6084
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, TBXAS1, ALOX12 4.0074
Ras signaling pathway_Homo sapiens_hsa04014 INSR, KIT, KDR, TEK, MET, EGFR, IGF1R 3.1137
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, MMP2, BCL2, PIM1, F3 3.0554
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, BCL2, TEK, EGFR, IGF1R 3.0374
Serotonergic synapse_Homo sapiens_hsa04726 APP, MAOA, ALOX5, ALOX15, ALOX12 2.8874
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, EGFR, IGF1R 2.7192
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, KIT, MET, EGFR 2.76
Hepatitis B_Homo sapiens_hsa05161 CDK6, SMAD3, SRC, BCL2, MMP9 2.5248
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1, CYP3A4 2.7924
Melanoma_Homo sapiens_hsa05218 CDK6, MET, EGFR, IGF1R 2.73
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 MAOA, CYP1A2, AOX1, CYP3A4 2.7455
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 2.7455
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, EGFR, IGF1R 1.8219
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, ADORA1 1.9555
Glioma_Homo sapiens_hsa05214 CDK6, EGFR, IGF1R 1.8219
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 1.8219
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, KIT, PIM1 1.9465
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET, EGFR 1.5336
Pancreatic cancer_Homo sapiens_hsa05212 CDK6, SMAD3, EGFR 1.815
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, GPR35, ADORA3, ADORA1, DRD1 1.5042
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 1.7426
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 1.7899
Prostate cancer_Homo sapiens_hsa05215 BCL2, EGFR, IGF1R 1.5286
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 1.5214
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.4988
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, ADORA1, DRD1, PPARA 1.3791
Gap junction_Homo sapiens_hsa04540 SRC, DRD1, EGFR 1.5319
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2, CYP3A4 1.7486
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, BCL2 1.366
Insulin resistance_Homo sapiens_hsa04931 PTPN1, INSR, PPARA 1.3791
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2, HSPA1A 1.3034
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.2918
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1, HSPA1A 1.1796
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, CDC25B, HSPA1A 1.1426
Cell cycle_Homo sapiens_hsa04110 CDK6, SMAD3, CDC25B 1.2695
Phospholipase D signaling pathway_Homo sapiens_hsa04072 INSR, KIT, EGFR 1.1502
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, ESRRB, IGF1R 1.159
Tyrosine metabolism_Homo sapiens_hsa00350 MAOA, AOX1, TYR 2.5248
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1 1.086
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4 2.73
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, INSR, ADORA1 1.0379
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, DRD1, EGFR 0.9751
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2, HSPA1A 0.8979
Viral carcinogenesis_Homo sapiens_hsa05203 POLB, CDK6, SRC 0.8928
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, SRC, EGFR 0.8732
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2372
HTLV-I infection_Homo sapiens_hsa05166 POLB, SMAD3, TERT 0.7347
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.2369
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, EGFR 0.909
Influenza A_Homo sapiens_hsa05164 HSPA1A 0.25
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.2865
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 0.8732
Platelet activation_Homo sapiens_hsa04611 SRC, TBXAS1 0.7462
Parkinson's disease_Homo sapiens_hsa05012 DRD1 0.3037
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.2938
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, ALOX12 0.8732
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 0.8979
Apoptosis_Homo sapiens_hsa04210 BCL2 0.3053
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6, SMAD3 1.0166
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 0.9083
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2 0.9126
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.3161
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.7612
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.7612
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, IGF1R 0.739
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 0.8993
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 0.8918
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 0.9751
Melanogenesis_Homo sapiens_hsa04916 KIT, TYR 0.8693
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2, HSPA1A 0.6054
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.7181
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 0.8928
Axon guidance_Homo sapiens_hsa04360 MET 0.3304
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, INSR 0.7038
Purine metabolism_Homo sapiens_hsa00230 POLA1, XDH 0.5984
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3379
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.6619
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.7038
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.6927
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.343
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, EGFR 0.6349
Dopaminergic synapse_Homo sapiens_hsa04728 MAOA, DRD1 0.7321
Alzheimer's disease_Homo sapiens_hsa05010 BACE1, APP 0.6054
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.3689
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.5984
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 0.9722
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.1223
Alcoholism_Homo sapiens_hsa05034 MAOA, DRD1 0.5984
Amphetamine addiction_Homo sapiens_hsa05031 MAOA, DRD1 1.0723
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.382
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6, EGFR 1.159
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.389
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.389
Pyrimidine metabolism_Homo sapiens_hsa00240 POLA1 0.3816
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4012
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4006
Legionellosis_Homo sapiens_hsa05134 CLK1, HSPA1A 1.159
Colorectal cancer_Homo sapiens_hsa05210 SMAD3, BCL2 1.1156
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.086
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4219
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.4353
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.421
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.1426
Peroxisome_Homo sapiens_hsa04146 XDH 0.4366
Cocaine addiction_Homo sapiens_hsa05030 MAOA, DRD1 1.2383
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.4605
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.4719
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.4891
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2, INSR 1.3791
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.4912
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5045
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP3A4, XDH 1.2752
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5096
Shigellosis_Homo sapiens_hsa05131 SRC 0.507
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5306
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.5214
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.5819
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.586
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.4988
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.422
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOA 0.5904
Malaria_Homo sapiens_hsa05144 MET 0.5948
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.5984
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.5984
Base excision repair_Homo sapiens_hsa03410 POLB, APEX1 1.4862
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.5984
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.5984
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.6054
Cysteine and methionine metabolism_Homo sapiens_hsa00270 DNMT1 0.6002
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.7066
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.6661
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOA 0.6319
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.6319
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.7347
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7038
DNA replication_Homo sapiens_hsa03030 POLA1 0.6619
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7181
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7373
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7084
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7347
Histidine metabolism_Homo sapiens_hsa00340 MAOA 0.757
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOA 0.8732
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.8623
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.9083
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 2.8162
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.159


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
Select to Download
1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)