Description of the Component
Component ID |
TCMH950 |
Latin Name |
Phellodendron amurense |
English Name |
Amur corktree |
Chinese Pinyin Name |
Huang Bai Fen |
中文名 |
黄柏粉 |
TCM Properties |
|
TCM Meridians |
|
Therapeutic Class English |
|
Therapeutic Class Chinese |
|
Functions |
|
Toxicity |
NA |
Geo-authentic habitats (道地产区) |
NA |
Reference |
CFDA |
Barcode ID |
ITSAM1586-14 |
Barcode Source |
BOLDSYSTEMS |
TCM Prescriptions with the Component
| Prescription ID | Prescription English Name | Prescription Chinese Name |
|---|---|---|
| TCMFx6938 | Zheng Lu Pills | 正露丸 |
Targeted Human Proteins by the Ingredient of Component
| Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
|---|---|---|---|---|
| TCMT1 | EHMT2 | Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 | Transferase | Q96KQ7 |
| TCMT100 | TTR | Transthyretin | Unclassified | P02766 |
| TCMT101 | PTPN1 | Protein-tyrosine phosphatase 1B | Hydrolase | P18031 |
| TCMT11 | HIF1A | Hypoxia-inducible factor 1 alpha | Transcription factor | Q16665 |
| TCMT125 | GBA | Beta-glucocerebrosidase | Hydrolase | P04062 |
| TCMT126 | TERT | Telomerase reverse transcriptase | Transferase | O14746 |
| TCMT131 | ACHE | Acetylcholinesterase | Hydrolase | P22303 |
| TCMT132 | BCHE | Butyrylcholinesterase | Hydrolase | P06276 |
| TCMT133 | CA1 | Carbonic anhydrase I | Lyase | P00915 |
| TCMT134 | CA2 | Carbonic anhydrase II | Lyase | P00918 |
| TCMT135 | CA14 | Carbonic anhydrase XIV | Lyase | Q9ULX7 |
| TCMT136 | CA12 | Carbonic anhydrase XII | Lyase | O43570 |
| TCMT137 | CA9 | Carbonic anhydrase IX | Lyase | Q16790 |
| TCMT138 | CA7 | Carbonic anhydrase VII | Lyase | P43166 |
| TCMT139 | CA6 | Carbonic anhydrase VI | Lyase | P23280 |
| TCMT140 | CA5B | Carbonic anhydrase VB | Lyase | Q9Y2D0 |
| TCMT141 | CA5A | Carbonic anhydrase VA | Lyase | P35218 |
| TCMT142 | CA4 | Carbonic anhydrase IV | Lyase | P22748 |
| TCMT143 | CA3 | Carbonic anhydrase III | Lyase | P07451 |
| TCMT150 | RORC | Nuclear receptor ROR-gamma | Nuclear receptor | P51449 |
| TCMT156 | CYP19A1 | Cytochrome P450 19A1 | Oxidoreductase | P11511 |
| TCMT159 | TYR | Tyrosinase | Oxidoreductase | P14679 |
| TCMT160 | HTR7 | Serotonin 7 (5-HT7) receptor | GPCR | P34969 |
| TCMT161 | HCAR2 | Hydroxycarboxylic acid receptor 2 | GPCR | Q8TDS4 |
| TCMT162 | UGT1A1 | UDP-glucuronosyltransferase 1-1 | Transferase | P22309 |
| TCMT17 | POLB | DNA polymerase beta | Transferase | P06746 |
| TCMT176 | SOAT1 | Acyl coenzyme A:cholesterol acyltransferase 1 | Transferase | P35610 |
| TCMT18 | GAA | Lysosomal alpha-glucosidase | Hydrolase | P10253 |
| TCMT2 | MAPT | Microtubule-associated protein tau | Unclassified | P10636 |
| TCMT206 | CYP2A6 | Cytochrome P450 2A6 | Oxidoreductase | P11509 |
| TCMT207 | BACE1 | Beta-secretase 1 | Protease | P56817 |
| TCMT214 | MGLL | Monoglyceride lipase | Unclassified | Q99685 |
| TCMT223 | AKR1B1 | Aldose reductase | Oxidoreductase | P15121 |
| TCMT225 | CA13 | Carbonic anhydrase XIII | Lyase | Q8N1Q1 |
| TCMT232 | ABCB1 | P-glycoprotein 1 | Transporter | P08183 |
| TCMT27 | DRD1 | Dopamine D1 receptor | GPCR | P21728 |
| TCMT276 | SLCO2B1 | Solute carrier organic anion transporter family member 2B1 | Transporter | O94956 |
| TCMT277 | SLCO1B3 | Solute carrier organic anion transporter family member 1B3 | Transporter | Q9NPD5 |
| TCMT278 | SLCO1B1 | Solute carrier organic anion transporter family member 1B1 | Transporter | Q9Y6L6 |
| TCMT280 | AKR1B10 | Aldo-keto reductase family 1 member B10 | Oxidoreductase | O60218 |
| TCMT281 | DPP4 | Dipeptidyl peptidase IV | Unclassified | P27487 |
| TCMT297 | FABP4 | Fatty acid binding protein adipocyte | Unclassified | P15090 |
| TCMT3 | ALOX15 | Arachidonate 15-lipoxygenase | Oxidoreductase | P16050 |
| TCMT307 | KCNH2 | HERG | Ion channel | Q12809 |
| TCMT309 | SLC22A2 | Solute carrier family 22 member 2 | Transporter | O15244 |
| TCMT31 | CYP2C19 | Cytochrome P450 2C19 | Oxidoreductase | P33261 |
| TCMT310 | SLC47A2 | Multidrug and toxin extrusion protein 2 | Transporter | Q86VL8 |
| TCMT311 | SLC47A1 | Multidrug and toxin extrusion protein 1 | Transporter | Q96FL8 |
| TCMT321 | MMP9 | Matrix metalloproteinase 9 | Hydrolase | P14780 |
| TCMT33 | CYP3A4 | Cytochrome P450 3A4 | Oxidoreductase | P08684 |
| TCMT332 | AOC3 | Amine oxidase, copper containing | Oxidoreductase | Q16853 |
| TCMT336 | IDO1 | Indoleamine 2,3-dioxygenase | Oxidoreductase | P14902 |
| TCMT34 | CYP2D6 | Cytochrome P450 2D6 | Oxidoreductase | P10635 |
| TCMT344 | AOX1 | Aldehyde oxidase | Oxidoreductase | Q06278 |
| TCMT36 | HTR1A | Serotonin 1a (5-HT1a) receptor | GPCR | P08908 |
| TCMT37 | HTR2A | Serotonin 2a (5-HT2a) receptor | GPCR | P28223 |
| TCMT38 | DRD2 | Dopamine D2 receptor | GPCR | P14416 |
| TCMT41 | IDH1 | Isocitrate dehydrogenase [NADP] cytoplasmic | Oxidoreductase | O75874 |
| TCMT42 | KMT2A | Histone-lysine N-methyltransferase MLL | Transferase | Q03164 |
| TCMT45 | APP | Beta amyloid A4 protein | Unclassified | P05067 |
| TCMT46 | F3 | Coagulation factor III | Unclassified | P13726 |
| TCMT6 | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | Transcription factor | P19838 |
| TCMT615 | SENP8 | Sentrin-specific protease 8 | Protease | Q96LD8 |
| TCMT63 | PPARA | Peroxisome proliferator-activated receptor alpha | Nuclear receptor | Q07869 |
| TCMT637 | SIRT3 | NAD-dependent deacetylase sirtuin 3 | Hydrolase | Q9NTG7 |
| TCMT638 | SIRT2 | NAD-dependent deacetylase sirtuin 2 | Hydrolase | Q8IXJ6 |
| TCMT64 | PPARD | Peroxisome proliferator-activated receptor delta | Nuclear receptor | Q03181 |
| TCMT67 | PPARG | Peroxisome proliferator-activated receptor gamma | Nuclear receptor | P37231 |
| TCMT737 | APOBEC3G | DNA dC->dU-editing enzyme APOBEC-3G | Unclassified | Q9HC16 |
| TCMT8 | KDM4E | Lysine-specific demethylase 4D-like | Oxidoreductase | B2RXH2 |
| TCMT80 | MAPK1 | MAP kinase ERK2 | Kinase | P28482 |
| TCMT82 | ESR1 | Estrogen receptor alpha | Nuclear receptor | P03372 |
Targeted Pathogenic Microbes by the Ingredient of Component
| Target ID | Target Name |
|---|---|
| TCMT1104 | Sortase |
| TCMT1109 | Reverse transcriptase |
| TCMT1112 | Quinolone resistance protein norA |
| TCMT1154 | Sortase |
| TCMT1218 | Staphylococcus aureus |
| TCMT1226 | Klebsiella pneumoniae |
| TCMT1230 | Human herpesvirus 5 |
| TCMT1232 | Pseudomonas aeruginosa |
| TCMT1236 | Mycobacterium bovis |
| TCMT1246 | Escherichia coli |
| TCMT1251 | Candida albicans |
| TCMT1255 | Human immunodeficiency virus 1 |
| TCMT1286 | Bacillus cereus |
| TCMT1289 | Shigella dysenteriae |
| TCMT1305 | Salmonella enteritidis |
| TCMT1318 | Human T-lymphotropic virus 1 |
| TCMT1346 | Helicobacter pylori |
| TCMT1353 | Plasmodium yoelii |
| TCMT1382 | Plasmodium falciparum (isolate K1 / Thailand) |
| TCMT1385 | Candida shehatae |
| TCMT1438 | Plasmodium falciparum |
| TCMT1439 | Mycobacterium smegmatis |
| TCMT1454 | Bacillus subtilis |
| TCMT1455 | Mycobacterium tuberculosis H37Rv |
| TCMT1458 | Filobasidiella neoformans |
| TCMT1460 | Mycobacterium intracellulare |
| TCMT1463 | Mycobacterium tuberculosis |
| TCMT1465 | Entamoeba histolytica |
Ingredient Structrues
Ingredient ID: TCMC934
Formula: C20H19NO4
Ingredient ID: TCMC897
Formula: C16H18O9
Ingredient ID: TCMC865
Formula: C14H8N2O
Ingredient ID: TCMC858
Formula: C20H21NO4
Ingredient ID: TCMC801
Formula: C29H50O
Ingredient ID: TCMC785
Formula: C20H18NO4.ClH
Ingredient ID: TCMC784
Formula: C20H18NO4
Ingredient ID: TCMC315
Formula: C21H25NO4
Ingredient ID: TCMC313
Formula: C20H23NO4
Ingredient ID: TCMC2811
Formula: C19H15NO4
Ingredient ID: TCMC2442
Formula: C13H11NO3
Ingredient ID: TCMC2402
Formula: C15H14O2
Ingredient ID: TCMC2383
Formula: C20H23NO4
Ingredient ID: TCMC2378
Formula: C19H15NO4.ClH
Ingredient ID: TCMC2198
Formula: C37H40N2O6
Ingredient ID: TCMC2191
Formula: C14H12O3
Ingredient ID: TCMC2151
Formula: C20H23NO4
Ingredient ID: TCMC2150
Formula: C21H25NO4
Ingredient ID: TCMC2146
Formula: C20H21NO4
Ingredient ID: TCMC2086
Formula: C14H13NO4
Ingredient ID: TCMC2030
Formula: C18H13N3O
Ingredient ID: TCMC1871
Formula: C6H6O
Ingredient ID: TCMC1869
Formula: C8H11N
Ingredient ID: TCMC1866
Formula: C17H16O5
Ingredient ID: TCMC1831
Formula: C21H22NO4
Ingredient ID: TCMC1828
Formula: C21H22NO4.ClH
Ingredient ID: TCMC1788
Formula: C18H34O2
Ingredient ID: TCMC1771
Formula: C26H30O7
Ingredient ID: TCMC1761
Formula: C10H9NO3
Ingredient ID: TCMC1659
Formula: C20H19NO5
Ingredient ID: TCMC1636
Formula: C20H18NO4
Ingredient ID: TCMC1622
Formula: C19H17N3O
Ingredient ID: TCMC1621
Formula: C20H21NO4
Ingredient ID: TCMC1586
Formula: C17H20N2O
Ingredient ID: TCMC1491
Formula: C26H30O8
Ingredient ID: TCMC1424
Formula: C20H19NO4
Ingredient ID: TCMC1417
Formula: C8H8O3
Ingredient ID: TCMC1389
Formula: C10H12O2
Ingredient ID: TCMC1342
Formula: C21H25NO4.ClH
Ingredient ID: TCMC1210
Formula: C13H11NO3
Ingredient ID: TCMC1173
Formula: C10H10O4
Ingredient ID: TCMC1145
Formula: C11H12O4
Ingredient ID: TCMC1131
Formula: C9H6O4
Properties
| Ingredient ID | Formulae | Name | MW | AlogP | MlogP | XlogP | # HBA | # HBD | PSA | # Rotatable Bond | # Ring | # Heacy Atom | Lipinski RO5 Violation |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TCMC313 | C20H23NO4 | 2,3,10-Trimethoxy-6,8,13,13A-Tetrahydro-5H-Isoquinolino[2,1-B]Isoquinolin-9-Ol | 341.16 | -0.3117 | 3.11 | 2.029 | 1 | 1 | 51.16 | 7 | 4 | 25 | 0 |
| TCMC315 | C21H25NO4 | 2,3,9,10-Tetramethoxy-6,8,13,13A-Tetrahydro-5H-Isoquinolino[2,1-B]Isoquinoline | 355.18 | 0.0968 | 3.22 | 2.548 | 1 | 0 | 40.16 | 8 | 4 | 26 | 0 |
| TCMC784 | C20H18NO4 | Berberine | 336.12 | -1.583 | 3.11 | 2.896 | 0 | 0 | 40.8 | 4 | 5 | 25 | 0 |
| TCMC785 | C20H18NO4.ClH | Berberine Chloride | 336.12 | -1.583 | 3.11 | 2.896 | 0 | 0 | 40.8 | 4 | 5 | 25 | 0 |
| TCMC801 | C29H50O | Beta-Sitosterol | 414.39 | 1.3 | 4.54 | 11.595 | 1 | 1 | 20.23 | 13 | 4 | 30 | 1 |
| TCMC858 | C20H21NO4 | Canadine | 339.15 | -0.1023 | 3.11 | 2.475 | 1 | 0 | 40.16 | 4 | 5 | 25 | 0 |
| TCMC865 | C14H8N2O | Canthin-6-One | 220.06 | -0.2737 | 2.67 | 2.809 | 3 | 0 | 34.89 | 0 | 4 | 17 | 0 |
| TCMC897 | C16H18O9 | Chlorogenic Acid | 354.1 | -2.1962 | 2.23 | -0.447 | 7 | 6 | 164.75 | 11 | 2 | 25 | 1 |
| TCMC934 | C20H19NO4 | Columbamine | 338.14 | -1.7924 | 3.11 | 2.45 | 0 | 1 | 51.8 | 7 | 4 | 25 | 0 |
| TCMC1131 | C9H6O4 | Esculetin | 178.03 | -0.6506 | 2.01 | 0.998 | 1 | 2 | 66.76 | 2 | 2 | 13 | 0 |
| TCMC1145 | C11H12O4 | Ethyl Caffeate | 208.07 | -0.2979 | 2.23 | 1.885 | 2 | 2 | 66.76 | 7 | 1 | 15 | 0 |
| TCMC1173 | C10H10O4 | Ferulic Acid | 194.06 | -0.3908 | 2.12 | 1.231 | 2 | 2 | 66.76 | 6 | 1 | 14 | 0 |
| TCMC1210 | C13H11NO3 | Gamma-Fagarine | 229.07 | -0.2577 | 2.45 | 2.068 | 1 | 0 | 44.49 | 4 | 3 | 17 | 0 |
| TCMC1342 | C21H25NO4.ClH | Hydron;2,3,9,10-Tetramethoxy-6,8,13,13A-Tetrahydro-5H-Isoquinolino[2,1-B]Isoquinoline;Chloride | 355.18 | 0.0968 | 3.22 | 2.548 | 1 | 0 | 40.16 | 8 | 4 | 26 | 0 |
| TCMC1389 | C10H12O2 | Isoeugenol | 164.08 | 0.3952 | 2.34 | 2.805 | 0 | 1 | 29.46 | 5 | 1 | 12 | 0 |
| TCMC1417 | C8H8O3 | Isovanillin | 152.05 | -0.7045 | 2.01 | 1.04 | 1 | 1 | 46.53 | 4 | 1 | 11 | 0 |
| TCMC1424 | C20H19NO4 | Jatrorrhizine | 338.14 | -1.5606 | 3.11 | 1.039 | 2 | 1 | 49.2 | 6 | 4 | 25 | 0 |
| TCMC1491 | C26H30O8 | Limonin | 470.19 | -0.4484 | 3.44 | 1.644 | 7 | 0 | 104.57 | 5 | 7 | 34 | 0 |
| TCMC1586 | C17H20N2O | Michler's Ketone | 268.16 | 0.1718 | 3 | 3.609 | 3 | 0 | 23.55 | 8 | 2 | 20 | 0 |
| TCMC1621 | C20H21NO4 | 339.15 | -0.1023 | 3.11 | 2.475 | 1 | 0 | 40.16 | 4 | 5 | 25 | 0 | |
| TCMC1622 | C19H17N3O | 303.14 | -0.5403 | 3.11 | 3.89 | 4 | 1 | 39.34 | 1 | 5 | 23 | 0 | |
| TCMC1636 | C20H18NO4 | 336.12 | -1.583 | 3.11 | 2.896 | 0 | 0 | 40.8 | 4 | 5 | 25 | 0 | |
| TCMC1659 | C20H19NO5 | 353.13 | -0.4401 | 3 | 1.86 | 2 | 0 | 57.23 | 1 | 5 | 26 | 0 | |
| TCMC1761 | C10H9NO3 | Noroxyhydrastinine | 191.06 | -0.3413 | 2.12 | 1.117 | 2 | 1 | 51.05 | 1 | 3 | 14 | 0 |
| TCMC1771 | C26H30O7 | Obacunone | 454.2 | 0.7128 | 3.55 | 2.69 | 6 | 0 | 95.34 | 6 | 6 | 33 | 0 |
| TCMC1788 | C18H34O2 | Oleic Acid | 282.26 | -2.3427 | 3.22 | 8.192 | 2 | 1 | 37.3 | 17 | 0 | 20 | 2 |
| TCMC1828 | C21H22NO4.ClH | Palmatine Chloride | 352.15 | -1.3839 | 3.22 | 2.969 | 0 | 0 | 40.8 | 8 | 4 | 26 | 0 |
| TCMC1831 | C21H22NO4 | Palmitine | 352.15 | -1.3839 | 3.22 | 2.969 | 0 | 0 | 40.8 | 8 | 4 | 26 | 0 |
| TCMC1866 | C17H16O5 | Phellopterin | 300.1 | 1.4778 | 2.78 | 2.447 | 1 | 0 | 57.9 | 7 | 3 | 22 | 0 |
| TCMC1869 | C8H11N | Phenethylamine | 121.09 | -0.4827 | 2.23 | 3.122 | 1 | 1 | 26.02 | 3 | 1 | 9 | 0 |
| TCMC1871 | C6H6O | Phenol | 94.04 | -0.4603 | 2.01 | 2.044 | 0 | 1 | 20.23 | 1 | 1 | 7 | 0 |
| TCMC2030 | C18H13N3O | Rutaecarpine | 287.11 | -0.7533 | 3 | 3.951 | 4 | 1 | 48.46 | 0 | 5 | 22 | 0 |
| TCMC2086 | C14H13NO4 | Skimmianine | 259.08 | -0.3095 | 2.45 | 1.624 | 1 | 0 | 53.72 | 6 | 3 | 19 | 0 |
| TCMC2146 | C20H21NO4 | Tetrahydroberberine | 339.15 | -0.1023 | 3.11 | 2.475 | 1 | 0 | 40.16 | 4 | 5 | 25 | 0 |
| TCMC2150 | C21H25NO4 | Tetrahydropalmatine | 355.18 | 0.0968 | 3.22 | 2.548 | 1 | 0 | 40.16 | 8 | 4 | 26 | 0 |
| TCMC2151 | C20H23NO4 | Tetrahydropalmatrubine | 341.16 | -0.3117 | 3.11 | 2.029 | 1 | 1 | 51.16 | 7 | 4 | 25 | 0 |
| TCMC2191 | C14H12O3 | Trioxsalen | 228.08 | 1.6438 | 2.67 | 2.805 | 1 | 0 | 39.44 | 3 | 3 | 17 | 0 |
| TCMC2198 | C37H40N2O6 | Tubocurarine | 609.3 | -1.8978 | 4.65 | 4.869 | 1 | 2 | 80.62 | 9 | 6 | 45 | 0 |
| TCMC2378 | C19H15NO4.ClH | Thalifendine | 321.1 | -0.1514 | 3 | 2.164 | 3 | 0 | 48 | 2 | 5 | 24 | 0 |
| TCMC2383 | C20H23NO4 | Magnoflorine | 342.17 | -1.9843 | 3.11 | 1.008 | 0 | 2 | 58.92 | 8 | 4 | 25 | 0 |
| TCMC2402 | C15H14O2 | 4-[(Z)-2-(3-Methoxyphenyl)Ethenyl]Phenol | 226.1 | -0.0443 | 2.89 | 5.129 | 0 | 1 | 29.46 | 5 | 2 | 17 | 1 |
| TCMC2442 | C13H11NO3 | Pteleine | 229.07 | -0.2577 | 2.45 | 2.068 | 1 | 0 | 44.49 | 4 | 3 | 17 | 0 |
| TCMC2811 | C19H15NO4 | Thalidendine | 322.11 | -0.1281 | 3 | 2.096 | 2 | 1 | 30.93 | 2 | 5 | 24 | 0 |
Download Data
All data can be downloaded by:→ Selecting data type in the below download table
→ Then click the download button.
