Component: Cimicifuga foetida 升麻

Description of the Component

Component ID
Latin Name
Cimicifuga foetida
English Name
Chinese Pinyin Name
Sheng Ma
TCM Properties
Minor cold,Pungent
TCM Meridians
Lung,Spleen,Large Intestine,Stomach
Therapeutic Class English
For relieving exterior syndrome
Therapeutic Class Chinese
induce perspiration and promote eruption, remove toxic heat, and cure drooping and ptosis
Geo-authentic habitats (道地产区)
Sichuan Province,Chongqing, Heilongjiang Province
Chinese Pharmacopoeia (2015)
Barcode ID
Barcode Source

TCM Prescriptions with the Component

Prescription ID Prescription English Name Prescription Chinese Name
TCMF7260 益气聪明汤
TCMF2434 Added Flavor DFZ Heat Clearing Decoction 加味地肤子汤
TCMF2390 Added Flavor Interior Tonification Decoction 加味补中益气汤
TCMF1313 Bolus for Reinforcing Middle-jiao and Replenishing Qi 补中益气丸
TCMF2021 Bolus for Reinforcing Middle-jiao and Replenishing Qi 补中益气丸
TCMF3899 Bu Qi Yi Qi Tablets 补气益气片
TCMF609 Bu Zhong Yi Qi Granules 补中益气颗粒
TCMF3108 Bu Zhong Yi Qi Ointment 补中益气膏
TCMF3125 Bu Zhong Yi Qi Pills 补中益气丸
TCMF3116 Bu Zhong Yi Qi Recipe 补中益气合剂
TCMF608 Bu Zhong Yi Qi Recipe 补中益气合剂
TCMFx3251 Chi Tong Ning 齿痛宁
TCMF3513 Chuang Yang Ointment 疮疡膏
TCMFx3562 Chun Chi Qing Wei Pills 唇齿清胃丸
TCMF2697 Cimicifuga and Kudzu Decoction 升麻葛根汤
TCMF2716 Cimicifuga Formula 乙字汤
TCMF7371 Dang Gui Nian Tong Decoction 当归拈痛汤
TCMF3078 Dang Gui Nian Tong Pills 当归拈痛丸
TCMF503 Dang Gui Nian Tong Pills 当归拈痛丸
TCMF3070 Dang Gui Nian Tong Recipe 当归拈痛合剂
TCMF2073 Danger Relieving Decoction
TCMF2052 Decoction for Dysphagia 通幽汤
TCMF2333 Decoction for Lifting Up Yang and Expelling Fire 生阳散火汤
TCMF1723 Decoction for Raising Primordial Energy 举元煎
TCMF2609 Decoction for Restoring Yin and Purging Fire
TCMF2204 Decoction for Strenthening Middle Jiao and Benefiting Vital Energy 补中益气汤
TCMF7252 Decoction for Strenthening Middle Jiao and Benefiting Vital Energy 补中益气汤
TCMF2559 Decoction of Angelicae Sinensis for Analgesic 当归拈痛汤
TCMFx1669 Decoction of Cimicifugae and Astragali seu Hedysari 升麻黄芩汤
TCMF1668 Decoction of Cimicifugae and Puerariae 升麻葛根汤
TCMF1991 Early Stage Decoction
TCMF3893 Er Tong Hui Chun Granules 儿童回春颗粒
TCMF3901 Er Tong Hui Chun Pills 儿童回春丸
TCMFx3079 Er Xian Pills 二仙丸
TCMF6996 Fu Fang Jue Ming Tablets 复方决明片
TCMFx6922 Fu Kang Oral Liquid 妇康口服液
TCMF3705 Gan Mao Jie Biao Pills 感冒解表丸
TCMF3280 Gong Xue Ting Granules 宫血停颗粒
TCMFx478 Gua Shuang Tui Re Ling Capsule 瓜霜退热灵胶囊
TCMFx3654 Gua Shuang Tui Re Ling Capsules 瓜霜退热灵胶囊
TCMF2350 Hepatitis B Decoction 益肝汤
TCMF4066 Huang Lian Qing Wei Pills 黄连清胃丸
TCMFx2852 Ji Chuan Decoction 济川煎
TCMFx1803 Jichuan Decoction 济川煎
TCMF648 Jin Hua Ming Mu Pills 金花明目丸
TCMF2469 Kidney Tonification Decoction
TCMF2661 Kudzu Decoction 葛根汤
TCMF2889 Liang Xue Di Huang Decoction 凉血地黄汤
TCMF4179 Liang Xue Qu Feng Syrup 凉血祛风糖浆
TCMF1840 Lifting and Benefiting Decoction
TCMFx4965 Lv Xue 绿雪
TCMFx4973 Lv Xue Capsules 绿雪胶囊
TCMF2650 Magnolia Flower Clear the Lung Decoction 辛夷清肺汤
TCMF2462 Plus and Minus Eight Pearl Decoction 加减八珍汤
TCMF2182 Plus and Minus Qi Benefiting Decoction 加减益气固冲汤
TCMF4722 Pu Ji Hui Chun Pills 普济回春丸
TCMF7392 Pu Ji Xiao Du Decoction 普济消毒饮
TCMFx2535 Purple Snowy Powder 紫雪丹
TCMF4848 Qi Li De Kang Tablets 芪力得康片
TCMF2109 Qi Lifting Decoction
TCMF2318 Qin Jiu Turtle Shell Decoction 秦艽鳖甲饮
TCMF7305 Qing Shu Yi Qi Decoction 清暑益气汤
TCMF73 Qing Shu Yi Qi Pills 清暑益气丸
TCMF5738 Qing Shu Yi Qi Pills 清暑益气丸
TCMFx2835 Qing Wei Powder 清胃散
TCMFx7323 Qing Wei Powder 清胃散
TCMFx5006 Qing Yu Bi Wen Dan 庆余辟瘟丹
TCMFx490 Qing Yu Pi Wen Dan 庆余辟瘟丹
TCMF5689 Ru Lu Ointment 乳鹿膏
TCMF7339 San Zhong Kui Jian Decoction 散肿溃坚汤
TCMF1963 SG Two Worm Decoction
TCMFx5703 Shang Ke Zhuang Gu Ointment 伤科壮骨膏
TCMFx5366 Shen Nong Zhen Tong Ointment 神农镇痛膏
TCMF7346 Sheng Ma Ge Gen Decoction 升麻葛根汤
TCMFx2862 Sheng Xian Decoction 升陷汤
TCMF7345 Shi Shen Decoction 十神汤
TCMFx1728 Stomach Cooling Powder 清胃散
TCMF2684 Tonify the Middle and Augment the Qi Decoction 补中益气汤
TCMF5156 Tou Biao Hui Chun Pills 透表回春丸
TCMF2501 Tree Flower Haemorrhoid Control Decoction 槐花消痔汤
TCMF6006 Xiao Cuo Pills 消痤丸
TCMF953 Xiao Cuo Pills 消痤丸
TCMF6584 Xiao Er Bi Yan Tablets 小儿鼻炎片
TCMFx6005 Xiao Er Jing An Pills 小儿惊安丸
TCMF7347 Xin Yi Powder 辛夷散
TCMF2825 Xin Yi Powder 辛夷散
TCMF7331 Xin Yi Qing Fei Decoction 辛夷清肺汤
TCMF6575 Xue Ya Ping Tablets 血压平片
TCMF6598 Xun Ma Zhen Pills 荨麻疹丸
TCMF6566 Yi Qi Cong Ming Pills 益气聪明丸
TCMF7398 Yi Zi Decoction 乙字汤
TCMF1129 Zhang Yan Ming Tablet 障眼明片
TCMF6040 Zhang Yan Ming Tablets 障眼明片
TCMFx6833 Zhang Zhou Shen Qu 漳州神曲
TCMF6437 Zhi Hong Chang Bi Pills 止红肠辟丸
TCMF315 Zhi Hong Chang Pi Pills 止红肠辟丸
TCMFx120 Zi Xue Powder 紫雪散

Targeted Human Proteins by the Ingredient of Component

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT1 EHMT2 Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Transferase Q96KQ7
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT125 GBA Beta-glucocerebrosidase Hydrolase P04062
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT143 CA3 Carbonic anhydrase III Lyase P07451
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT166 AKR1C2 Aldo-keto reductase family 1 member C2 Oxidoreductase P52895
TCMT167 AKR1C3 Aldo-keto-reductase family 1 member C3 Oxidoreductase P42330
TCMT168 AKR1C4 Aldo-keto reductase family 1 member C4 Oxidoreductase P17516
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT18 GAA Lysosomal alpha-glucosidase Hydrolase P10253
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT221 ABCB11 Bile salt export pump Transporter O95342
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT248 CXCL8 Interleukin-8 Unclassified P10145
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT320 MMP3 Matrix metalloproteinase 3 Hydrolase P08254
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT6 NFKB1 Nuclear factor NF-kappa-B p105 subunit Transcription factor P19838
TCMT69 THRB Thyroid hormone receptor beta-1 Nuclear receptor P10828
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT80 MAPK1 MAP kinase ERK2 Kinase P28482
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT95 MPG DNA-3-methyladenine glycosylase Hydrolase P29372

Targeted Pathogenic Microbes by the Ingredient of Component

Target ID Target Name
TCMT1108 Integrase
TCMT1218 Staphylococcus aureus
TCMT1251 Candida albicans

Ingredient Structrues

Ingredient ID: TCMC847
Formula: C9H8O4

Ingredient ID: TCMC7330
Formula: C37H58O10

Ingredient ID: TCMC6687
Formula: C37H58O11

Ingredient ID: TCMC6462
Formula: C22H26N2O4

Ingredient ID: TCMC6415
Formula: C35H56O9

Ingredient ID: TCMC6307
Formula: C30H48O5

Ingredient ID: TCMC630
Formula: C37H56O11

Ingredient ID: TCMC6298
Formula: C22H28O10

Ingredient ID: TCMC4053
Formula: C12H8O4

Ingredient ID: TCMC3966
Formula: C29H50O

Ingredient ID: TCMC3865
Formula: C16H18O6

Ingredient ID: TCMC2906
Formula: C13H10O4

Ingredient ID: TCMC2084
Formula: C11H12O5

Ingredient ID: TCMC2037
Formula: C7H6O3

Ingredient ID: TCMC1390
Formula: C10H10O4

Ingredient ID: TCMC1173
Formula: C10H10O4


Ingredient ID Formulae Name MW AlogP MlogP XlogP # HBA # HBD PSA # Rotatable Bond # Ring # Heacy Atom Lipinski RO5 Violation
TCMC630 C37H56O11 Actein 676.38 -0.9166 4.32 5.056 11 4 156.67 15 9 48 2
TCMC847 C9H8O4 Caffeic Acid 180.04 -0.7993 2.01 1.141 2 3 77.76 5 1 13 0
TCMC1173 C10H10O4 Ferulic Acid 194.06 -0.3908 2.12 1.231 2 2 66.76 6 1 14 0
TCMC1390 C10H10O4 Isoferulic Acid 194.06 -0.3908 2.12 1.231 2 2 66.76 6 1 14 0
TCMC2037 C7H6O3 Salicylic Acid 138.03 -0.7001 1.9 2.264 2 2 57.53 3 1 10 0
TCMC2084 C11H12O5 Sinapinate 224.07 -0.4426 2.12 0.787 2 2 75.99 8 1 16 0
TCMC2906 C13H10O4 Visnagin 230.0579088 -0.3326 2.45 1.097 1 0 39.44 1 3 17 0
TCMC3865 C16H18O6 Cimifugin 306.1103383 -0.8588 2.56 0.019 3 2 75.99 3 3 22 0
TCMC3966 C29H50O Sitosterol,Β-Sitosterol 414.3861662 1.3 4.54 11.595 1 1 20.23 6 4 30 1
TCMC4053 C12H8O4 Norvisnagin 216.0422587 -0.7411 2.34 0.578 1 1 50.44 0 3 16 0
TCMC6298 C22H28O10 Visamminol 452.1682471 -1.9337 2.78 -0.052 7 4 134.91 5 4 32 0
TCMC6307 C30H48O5 Cimigenol 488.3501746 0.4019 4.21 6.252 5 3 79.15 1 7 35 1
TCMC6415 C35H56O9 Cimiaceroside B 620.3924334 -1.0275 4.32 6.027 9 5 138.07 2 8 44 1
TCMC6462 C22H26N2O4 Cimicilen 383.1970823 -3.4516 3.22 2.071 4 2 71.28 2 6 28 0
TCMC6687 C37H58O11 12Β-Acetoxycimigenol-3-O-Β-D-Xylopyranoside 678.3979127 -1.0283 4.32 4.253 11 5 164.37 5 8 48 1
TCMC7330 C37H58O10 23-O-Acetylshengmanol 3-O-Α-L-Arabinopyranoside 662.4029981 -0.802 4.43 5.969 10 4 155.28 8 7 47 1

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1. General Information of the Component  
2. TCM Prescriptions with the Component  
3. Putative Targets  
4. Activity & References for Filtering Putative Targets  
5. Ingredient Data & Chemical Structure Information (Properties, InChI, InChIkey, SMILES, etc.)