TCM Prescription: Pu Ji Xiao Du Decoction



Prescription Description
Prescription IDTCMF7392
Pinyin NamePu Ji Xiao Du Yin
Chinese Name普济消毒饮
English NamePu Ji Xiao Du Decoction
Function Description大头瘟症, 头面, 咽喉肿痛
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with IndicationBlood, Lung
ReferenceTaiwan Herbal Pharmacopeia 2nd Edition English Version
Reference Book/linkhttps://www.mohw.gov.tw/cp-3690-39025-2.html
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH986 Scutellaria baicalensis 黄芩 TCMH986 ITSAP4211-14
TCMH972 Coptis chinensis 黄连 TCMH972 ITSAO4469-14
TCMH228 Bupleurum chinense 柴胡 TCMH228 ITSAM2218-14
TCMH1080 Platycodon grandiflorum 桔梗 TCMH1080 ITSAJ4293-14
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
TCMH1272 Forsythia suspensa 连翘 TCMH1272 ITSAJ4444-14
TCMH1562 Arctium lappa 牛蒡子 TCMH1562 ITSAI1776-14
TCMH127 Isatis indigotica 板蓝根 TCMH127 KJ765825
TCMH1395 Lasiosphaera fenzlii 马勃 TCMH1395
TCMH75 Bombyx mori 白僵蚕 TCMH75 GBGL25918-19
TCMH188 Mentha haplocalyx 薄荷 TCMH188 HM595443
TCMH243 Pericarpium citri reticulatae 陈皮 TCMH243
TCMH2343 Scrophularia ningpoensis 玄参 TCMH2343 ITSAO4295-14
TCMH1906 Cimicifuga foetida 升麻 TCMH1906
Reference: Taiwan Herbal Pharmacopeia 2nd Edition English Version

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT118 MGAM Maltase-glucoamylase Hydrolase O43451
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT18 GAA Lysosomal alpha-glucosidase Hydrolase P10253
TCMT188 DHFR Dihydrofolate reductase Oxidoreductase P00374
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT241 CHRNA7 Neuronal acetylcholine receptor protein alpha-7 subunit Ion channel P36544
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT265 GSK3B Glycogen synthase kinase-3 beta Kinase P49841
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT552 CHRNA3 Neuronal acetylcholine receptor subunit alpha-3 Ion channel P32297
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT598 TOP1 DNA topoisomerase I Isomerase P11387
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT605 EDNRA Endothelin receptor ET-A GPCR P25101
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT801 TUBB3 Tubulin beta-3 chain Unclassified Q13509
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1191 Bacillus megaterium
TCMT1206 Influenza A virus (A/PR/8/34(H1N1))
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1241 Human rhinovirus 14
TCMT1243 Aspergillus flavus
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1283 Human enterovirus 71
TCMT1284 Penicillium expansum
TCMT1285 Human coxsackievirus B3
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1305 Salmonella enteritidis
TCMT1318 Human T-lymphotropic virus 1
TCMT1319 Corynebacterium xerosis
TCMT1321 Staphylococcus hominis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1333 Human rhinovirus 1A
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1347 Human rhinovirus 16
TCMT1348 Human rhinovirus 2
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1354 Streptococcus mutans UA159
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1385 Candida shehatae
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1460 Mycobacterium intracellulare
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, AXL, BCL2, CA9, CDK6, CHRNA3, CHRNA7, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DRD1, ESR1, ESRRA, FABP3, GRIK5, GRM5, GSK3B, HMGCR, HSD11B2, HSD17B2, IDO1, IGF1R, MMP2, MMP9, PPARA, PTGS2, RORC, SRC, TYR 12.1944
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CHRNA3, CHRNA7, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DHFR, DRD1, EDNRA, ESR1, F10, F3, FABP3, FABP4, FLT3, GAA, GRIA2, GRIA4, GRIK5, GRM1, GRM5, GSK3B, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KDR, MET, PPARA, PTGS2, SLC1A1, SRC, TNKS, TNKS2, XDH 12.1944
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, AXL, BCL2, CA2, CA9, CDK6, CHRNA3, CHRNA7, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DRD1, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, GSK3B, HMGCR, HSD11B2, HSD17B2, IDO1, IGF1R, KDR, MMP2, PPARA, PTGS2, RORC, SRC, TYR 10.6578
[BP] GO:0042221 response to chemical ABCB1, AKR1B1, ALOX15, ALPL, AXL, BCL2, CA2, CA9, CDK6, CHRNA3, CHRNA7, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DRD1, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, GSK3B, HMGCR, HSD11B2, HSD17B2, IDO1, IGF1R, KDR, MMP2, MMP9, PPARA, PTGS2, RORC, SRC, TOP1, TYR 10.2368
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AXL, BCL2, CHRNA3, CHRNA7, CYP19A1, CYP1A2, CYP1B1, DRD1, EDNRA, ESR1, ESRRB, F10, F3, FABP4, GAA, GRM1, GRM5, GRM8, HMGCR, HSD11B2, HSD17B2, IDO1, IGF1R, MET, MGAM, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, RORC, SRC, TNKS2, TOP1, TYR 8.45114
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DHFR, GAA, GSK3B, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, PTGS2, TYR, XDH 8.4454
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 8.42791
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, FABP3, FABP4, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MET, PPARA, PTGS2 8.42791
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, IDO1, PTGS2, RORC, SRC, TYR 7.63781
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DHFR, FABP3, FUT7, GAA, GBA2, HMGCR, IDO1, PIM1, PPARA, PTGS2, TYR, XDH 7.36286
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, ALOX15, AXL, BCL2, CA2, CA7, CHRNA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, F10, F3, FLT3, GRM1, GSK3B, HMGCR, KDR, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 7.05284
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, ALOX15, AXL, BCL2, CA2, CA7, CHRNA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, F10, F3, FLT3, GRM1, GSK3B, HMGCR, KDR, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 7.03466
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, BCL2, CA2, CA9, CHRNA3, CHRNA7, CSNK2A1, CYP1A2, DRD1, ESR1, ESRRA, FABP3, FLT3, GRM5, GSK3B, HSD11B2, IGF1R, MMP2, PPARA, PTGS2, SRC 7.0309
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CHRNA3, CHRNA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DHFR, DRD1, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, GSK3B, HMGCR, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC1A1, SRC, TNKS, TNKS2, XDH 6.8241
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9, DHFR 6.8241
[BP] GO:0042493 response to drug ABCB1, AKR1B1, AXL, BCL2, CA9, CDK6, CHRNA3, CHRNA7, CYP1A1, CYP1B1, DHFR, DRD1, FABP3, HMGCR, HSD11B2, KDR, PTGS2, SRC, TOP1 6.74119
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CHRNA3, CHRNA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, ESR1, ESR2, F10, F3, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, GSK3B, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PTGS2, PTPN1, PTPRS, SRC, TNKS, TNKS2, XDH 6.52311
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 6.52311
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CHRNA3, CHRNA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FLT3, GRIK5, GRM1, GRM5, GSK3B, HMGCR, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 6.51534
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, ALPL, AURKB, AXL, BCL2, CA2, CA9, CBR1, CDC25B, CDK6, CHRNA3, CHRNA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DRD1, EDNRA, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GAA, GBA2, GSK3B, HMGCR, HSD11B1, HSD17B2, KDR, MET, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPRS, RORC, SRC, TNKS2, TYR 6.51534
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, CA2, CA7, CHRNA3, CHRNA7, DRD1, GRIK5, GRM1, GRM3, GRM5, GRM8, PTGS2 6.51534
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, CA2, CA7, CHRNA3, CHRNA7, DRD1, GRIK5, GRM1, GRM3, GRM5, GRM8, PTGS2 6.51534
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CHRNA3, CHRNA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, ESR1, ESR2, F10, F3, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, GSK3B, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PTGS2, PTPN1, PTPRS, SRC, TNKS, TNKS2, XDH 6.4514
[BP] GO:0007215 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 6.37035
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.37035
[BP] GO:0014070 response to organic cyclic compound ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DRD1, ESR1, ESRRA, FLT3, HSD11B2, PTGS2, RORC, SRC, TYR 6.14924
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, ALPL, AURKB, AXL, BCL2, CA2, CA9, CDK6, CHRNA3, CHRNA7, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DRD1, EDNRA, ESR1, ESRRA, F10, F3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, GSK3B, HMGCR, HSD11B2, HSD17B2, IDO1, IGF1R, KDR, MMP12, MMP2, MMP9, PPARA, PTGS2, PTPN1, RORC, SRC, TOP1, TYR 6.12138
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 5.95021
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CHRNA3, CHRNA7, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, PPARA, PTGS2, SRC 5.94855
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, DRD1, GRM1, GRM3, GRM5, GRM8, PTGS2 5.55797
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DHFR, DRD1, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GAA, GBA2, GSK3B, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, MET, MGAM, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SRC, TNKS, TNKS2, TOP1, TYR, XDH 5.52506
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, ALPL, AXL, BCL2, CA2, CDK6, CHRNA3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DRD1, EDNRA, ESR1, ESRRA, ESRRB, FLT3, GAA, GBA2, GSK3B, HSD11B1, HSD17B2, KDR, MMP9, PIM1, PPARA, PTGS2, PTPRS, RORC, SRC, TYR 5.52029
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.49274
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, BCL2, CDC25B, CDK6, CHRNA7, CSNK2A1, CYP1B1, ESR1, ESRRA, F3, FABP3, FLT3, HMGCR, IDO1, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PTGS2, SRC, XDH 5.39689
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CHRNA7, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GRIK5, GSK3B, HMGCR, IDO1, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC, XDH 5.37916
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, ALOX15, AXL, BCL2, CHRNA7, CSNK2A1, CYP1B1, F10, F3, FLT3, GRM1, GSK3B, HMGCR, KDR, MET, MMP12, MMP9, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 5.37295
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 5.11033
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX15, BCL2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DHFR, DRD1, GBA2, HMGCR, TYR 5.10435
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, AXL, BCL2, CDK6, CYP1A1, CYP1B1, DRD1, ESR1, FABP4, FLT3, GRIK5, GRM5, GSK3B, IGF1R, KDR, MMP2, PTGS2, RORC, SRC 5.03101
[BP] GO:0048583 regulation of response to stimulus ABCB1, ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CDK6, CHRNA3, CHRNA7, CSNK2A1, CYP19A1, CYP1B1, DHFR, DRD1, ESR1, ESR2, ESRRA, F10, F3, FABP4, FLT3, GRM1, GSK3B, HMGCR, IDO1, IGF1R, KDR, MET, MMP12, MMP2, MMP9, PPARA, PTGS2, PTPN1, PTPRS, SRC, TNKS, TNKS2, XDH 5.02052
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CHRNA3, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.99691
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, BCL2, CDC25B, CHRNA3, CHRNA7, DRD1, EDNRA, ESRRB, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, MMP9, PPARA, PTGS2, PTPN1, SRC, XDH 4.97575
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, DRD1, ESR1, FABP4, FLT3, GRIK5, GRM5, GSK3B, IGF1R, KDR, MMP2, MMP9, PTGS2, RORC, SRC 4.93808
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ALOX15, BCL2, CDC25B, CHRNA3, CHRNA7, DRD1, EDNRA, ESRRB, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, MMP9, PPARA, PTGS2, PTPN1, SRC, XDH 4.92355
[BP] GO:0060078 None ADORA1, CHRNA3, CHRNA7, GRIA2, GRIA4, GRIK5, GRM5 4.9167
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, ALOX15, AXL, BCL2, CHRNA7, CSNK2A1, CYP1B1, ESRRA, F10, F3, FABP4, FLT3, GRM1, GSK3B, HMGCR, IDO1, KDR, MET, MMP12, MMP2, MMP9, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 4.9167
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 4.91529
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GRIK5, GSK3B, HMGCR, IDO1, IGF1R, KDR, MET, MMP9, PIM1, PTGS2, PTPN1, SRC, XDH 4.79772
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7, GRM5 4.73646
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.73646
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, PTGS2, SRC 4.69472
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GSK3B, HMGCR, IDO1, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC 4.67143
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EDNRA, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, PPARA, PTPRS, SRC, TYR 4.64124
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, GAA, GBA2, GSK3B, IDO1, MGAM, MMP1, MMP12, MMP2, MMP9, SRC, XDH 4.63665
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, GBA2, HMGCR, MET, PPARA, PTGS2 4.60483
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CDK6, DRD1, HMGCR, KDR, PTGS2, SRC, TNKS, TNKS2 4.59561
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS2 4.56335
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, AXL, BCL2, CHRNA7, CYP1B1, F10, F3, FLT3, GRM1, HMGCR, KDR, MET, PTGS2, PTPN1, SRC, XDH 4.54528
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GSK3B, HMGCR, IDO1, IGF1R, KDR, MET, MMP9, PIM1, PTGS2, PTPN1, SRC 4.53861
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ALOX15, AURKB, BCL2, CDC25B, CHRNA3, CHRNA7, CSNK2A1, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRM1, GRM5, GSK3B, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 4.50158
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ALOX15, BCL2, CDC25B, CHRNA3, CHRNA7, DRD1, ESRRB, FABP3, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PTGS2, PTPN1, SRC, XDH 4.50158
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ALOX15, BCL2, CDC25B, CHRNA3, CHRNA7, DRD1, ESRRB, FABP3, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PTGS2, PTPN1, SRC, XDH 4.50158
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CHRNA7, CYP1A1, EDNRA, HSD11B2, MMP2, PPARA, PTGS2, SRC 4.47452
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CDK6, CHRNA7, CSNK2A1, ESR1, F3, FLT3, HMGCR, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, PTGS2 4.46406
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA1, ADORA3, ALOX15, AXL, BCL2, CA2, CA7, CDK6, CHRNA3, CSNK2A1, CYP19A1, CYP1B1, DRD1, F10, F3, GRIK5, GRM5, GSK3B, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, SRC 4.45476
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ALOX15, AURKB, BCL2, CDC25B, CHRNA3, CHRNA7, CSNK2A1, DHFR, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GRM1, GRM5, GSK3B, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 4.44249
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DHFR, DRD1, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GAA, GBA2, GSK3B, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, MET, MGAM, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SRC, TNKS, TNKS2, TOP1, TYR, XDH 4.40808
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS2 4.40045
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CHRNA7, CYP1A1, EDNRA, HSD11B2, MMP2, PPARA, PTGS2, SRC 4.38314
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, GRIK5, GSK3B, HMGCR, IDO1, IGF1R, KDR, MMP9, PIM1, PTGS2, PTPN1, SRC, XDH 4.37316
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, AURKB, AXL, BCL2, CDK6, CHRNA7, CSNK2A1, CYP19A1, CYP1B1, DHFR, DRD1, EDNRA, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GRM3, GRM8, GSK3B, HMGCR, IDO1, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SRC, TNKS, TNKS2, XDH 4.23994
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DHFR, DRD1, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GAA, GBA2, GSK3B, HMGCR, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, MET, MGAM, MMP1, MMP2, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SRC, TNKS, TNKS2, TOP1, TYR, XDH 4.22704
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS2 4.22704
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.22704
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.22704
[BP] GO:1901698 response to nitrogen compound AKR1B1, CHRNA3, CHRNA7, DHFR, DRD1, FABP3, FLT3, GRM5, GSK3B, HSD11B2, IGF1R, MMP2, PPARA, PTGS2, SRC, TYR 4.21494
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DHFR, DRD1, FLT3, GSK3B, HMGCR, IGF1R, KDR, MET, PIM1, PTGS2, PTPN1, PTPRS, SRC, TNKS, TOP1, XDH 4.21182
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ALOX15, AURKB, BCL2, CDC25B, CHRNA3, CHRNA7, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GRM1, GRM5, GSK3B, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 4.21182
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ALOX15, AURKB, BCL2, CDC25B, CHRNA3, CHRNA7, CSNK2A1, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRM1, GRM5, GSK3B, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 4.16296
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CHRNA7, CYP1A1, EDNRA, HSD11B2, MMP2, PPARA, PTGS2, SRC 4.08745
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, AURKB, BCL2, CDC25B, CHRNA3, CHRNA7, CSNK2A1, DHFR, DRD1, EDNRA, ESR1, F3, FABP4, FLT3, GRM1, GRM3, GRM5, GSK3B, HMGCR, IGF1R, MMP9, PTGS2, PTPN1, SRC, TNKS, XDH 4.05614
[BP] GO:0060079 None ADORA1, CHRNA3, CHRNA7, GRIA2, GRIA4, GRIK5 4.04995
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, GSK3B, HMGCR, IDO1, IGF1R, KDR, MMP9, PIM1, PTGS2, PTPN1, SRC 4.00717
[BP] GO:0080134 regulation of response to stress ABCB1, ADORA1, CDK6, CYP19A1, DHFR, ESR1, F3, FABP4, GSK3B, HMGCR, IDO1, IGF1R, MET, MMP12, MMP2, PPARA, PTGS2, PTPN1, PTPRS, SRC, XDH 3.99706
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PTGS2 3.99197
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, DHFR, DRD1, ESR1, FABP4, FLT3, GRIK5, GRM1, GRM5, GSK3B, IGF1R, KDR, MMP2, MMP9, PTGS2, PTPN1, RORC, SRC 3.98987
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AXL, CDK6, CYP1B1, DRD1, ESR1, GRIK5, GRM5, GSK3B, IGF1R, MMP2, MMP9, PTGS2, RORC, SRC 3.98177
[BP] GO:0010243 response to organonitrogen compound AKR1B1, CHRNA7, DHFR, DRD1, FABP3, FLT3, GRM5, GSK3B, HSD11B2, IGF1R, MMP2, PPARA, PTGS2, SRC, TYR 3.93485
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, BCL2, CDC25B, CHRNA3, CHRNA7, ESRRB, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PTGS2, PTPN1, SRC, XDH 3.88999
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DHFR, DRD1, FLT3, GSK3B, HMGCR, IGF1R, KDR, MET, PIM1, PTGS2, PTPN1, PTPRS, SRC, TNKS, TOP1, XDH 3.88328
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, AXL, BCL2, CA12, CA2, CA7, CHRNA7, DRD1, EDNRA, ESR1, FABP3, FABP4, FLT3, GAA, GRIK5, GRM1, GRM5, MET, SRC 3.88133
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, RORC, SRC 3.86745
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, BCL2, CDC25B, CHRNA3, CHRNA7, DRD1, ESRRB, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MMP9, PPARA, PTGS2, PTPN1, SRC, XDH 3.82856
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, BCL2, CA2, CHRNA7, CYP1A1, DRD1, EDNRA, GRM1, HMGCR, HSD11B2, MMP2, PPARA, PTGS2, SRC, TYR 3.82322
[BP] GO:0042391 None ADORA1, BCL2, CHRNA3, CHRNA7, DRD1, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC 3.78422
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CHRNA7, CYP1A1, CYP1B1, DRD1, HMGCR, KDR, SRC 3.76637
[BP] GO:0065009 regulation of molecular function ABCB1, ADORA1, ADORA3, AURKB, BCL2, CDC25B, CHRNA3, CHRNA7, CSNK2A1, CYP1B1, DHFR, DRD1, EDNRA, ESR1, ESR2, F3, FABP4, FLT3, GRM1, GRM3, GRM5, GSK3B, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC, TNKS, XDH 3.76195
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CHRNA7, CSNK2A1, CYP1B1, ESR1, F10, F3, FLT3, GRM1, HMGCR, IGF1R, KDR, MET, MMP9, PTGS2, PTPN1, SRC, XDH 3.69268
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 3.67205
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, SLC1A1 3.62072
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CSNK2A1, CYP1B1, ESR1, FABP4, GRM3, GSK3B, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC, TNKS 3.61824
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, AURKB, AXL, BCL2, CDK6, CHRNA7, CSNK2A1, CYP19A1, CYP1B1, DHFR, DRD1, EDNRA, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GRM3, GRM8, GSK3B, HMGCR, IDO1, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SRC, TNKS, TNKS2, XDH 3.61247
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, BCL2, CDK6, CYP19A1, CYP1B1, DRD1, F10, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC 3.57316
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, FLT3, GSK3B, IGF1R, KDR, MET, PIM1, SRC, TNKS, TOP1 3.57316
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, PIM1, SRC 3.55864
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, AXL, BCL2, CA1, CSNK2A1, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, GSK3B, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC, TNKS, TNKS2 3.53885
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DHFR, DRD1, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GAA, GBA2, GSK3B, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, MET, MGAM, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SRC, TNKS, TNKS2, TOP1, TYR, XDH 3.53885
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, BCL2, CDC25B, CHRNA3, CHRNA7, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PTGS2, PTPN1, SRC, XDH 3.5314
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, GBA2 3.50389
[BP] GO:1901652 response to peptide AKR1B1, CHRNA7, FABP3, GRM5, GSK3B, HSD11B2, IGF1R, PPARA, PTGS2, SRC 3.49752
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DHFR, DRD1, IDO1 3.49752
[BP] GO:0044093 positive regulation of molecular function ABCB1, ADORA1, AURKB, BCL2, CDC25B, CHRNA3, CHRNA7, DHFR, EDNRA, ESR1, ESR2, F3, FLT3, GRM1, GRM5, GSK3B, MET, MMP9, PTPN1, SRC, TNKS, XDH 3.4698
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ALOX15, BCL2, CDK6, CYP19A1, DRD1, ESR1, ESR2, GSK3B, HMGCR, IGF1R, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, PTPRS, SRC, XDH 3.38342
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.3774
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, ESR1, GSK3B, PPARA, RORC, SRC, TOP1 3.34963
[BP] GO:0009987 cellular process ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CHRNA3, CHRNA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DHFR, DRD1, EDNRA, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GAA, GBA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, GSK3B, HMGCR, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, MET, MGAM, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SLC1A1, SRC, TNKS, TNKS2, TOP1, TUBB3, TYR, XDH 3.30927
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ALOX15, BCL2, CDC25B, CHRNA3, CHRNA7, DRD1, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MMP9, PTGS2, PTPN1, SRC, XDH 3.27596
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, AXL, BCL2, CA1, CA2, CDK6, CHRNA3, CHRNA7, CSNK2A1, CYP1B1, DRD1, EDNRA, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, GSK3B, IGF1R, KDR, MET, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SRC, TNKS, TNKS2 3.25457
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS2 3.25457
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, DRD1, F10, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC 3.25433
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS2 3.25433
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, DHFR, DRD1, ESR1, F10, F3, FLT3, FUT7, GBA2, GSK3B, HMGCR, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPN1, PTPRS, SRC, TNKS, TNKS2, TOP1, TYR, XDH 3.24717
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, PTGS2 3.2352
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, BCL2, CDK6, CYP19A1, CYP1B1, DRD1, F10, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC 3.23333
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, BCL2, CDK6, CYP19A1, CYP1B1, DRD1, F10, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC 3.21821
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, AXL, BCL2, CA2, CDK6, CHRNA3, CHRNA7, CYP1B1, ESR1, ESRRA, ESRRB, F3, GAA, GRM1, GSK3B, HMGCR, IDO1, KDR, MET, MMP12, MMP9, PIM1, PTGS2, PTPRS, SLC1A1, SRC, TNKS2, XDH 3.2052
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, DRD1, ESR1, F3, FABP4, HMGCR, IDO1, KDR, MET, MMP12, PPARA, PTGS2, PTPRS 3.2052
[BP] GO:0032787 None ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GBA2, IDO1, PPARA, PTGS2 3.16412
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX15, CYP19A1, CYP3A4, DHFR, HMGCR, TYR 3.15288
[BP] GO:0065007 biological regulation ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CDK6, CHRNA3, CHRNA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DHFR, DRD1, EDNRA, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GAA, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, GSK3B, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SLC1A1, SRC, TNKS, TNKS2, TOP1, XDH 3.14323
[BP] GO:0018105 peptidyl-serine phosphorylation AURKB, BCL2, DRD1, GSK3B, SRC, TNKS, TOP1 3.11004
[BP] GO:0048869 cellular developmental process ACHE, ALPL, AXL, BCL2, CBR1, CDC25B, CDK6, CHRNA7, CYP1A1, DRD1, EDNRA, ESR1, ESRRB, FABP4, FLT3, FUT7, GBA2, GSK3B, HMGCR, KDR, MET, MMP2, MMP9, PTGS2, PTPRS, RORC, SRC 3.10769
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 3.08754
[BP] GO:1904645 response to amyloid-beta CHRNA7, GRM5, GSK3B, IGF1R 3.05539
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.00095
[BP] GO:0048878 chemical homeostasis AKR1B1, BCL2, CA12, CA2, CA7, CHRNA7, DRD1, EDNRA, ESR1, FABP3, FABP4, GRIK5, GRM1, GRM5, MET 2.97245
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ALOX15, BCL2, CDC25B, CHRNA3, CHRNA7, CSNK2A1, ESR1, F3, FLT3, GRM1, GRM5, GSK3B, HMGCR, KDR, MMP9, PTGS2, PTPN1, SRC, XDH 2.91779
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, DHFR, PPARA 2.90574
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, HMGCR, IDO1 2.90574
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, CA2, CA7, CHRNA7, DRD1, PTGS2 2.85102
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CHRNA3, CYP1B1, DHFR, DRD1, GRIK5, PTGS2, SLC1A1 2.85102
[BP] GO:0018209 peptidyl-serine modification AURKB, BCL2, DRD1, GSK3B, SRC, TNKS, TOP1 2.83756
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, GBA2, IDO1, PIM1, PPARA, PTGS2, TYR 2.80364
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HMGCR 2.77976
[BP] GO:0044283 None AKR1B1, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP3A4, DHFR, HMGCR, IDO1, PTGS2 2.74831
[BP] GO:0009892 negative regulation of metabolic process ADORA1, AURKB, BCL2, CHRNA7, CSNK2A1, DHFR, EDNRA, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, GSK3B, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 2.74711
[BP] GO:0007610 None BCL2, CHRNA3, CHRNA7, DRD1, GAA, GRM1, GRM5, HMGCR, IDO1, PPARA, PTGS2 2.73993
[BP] GO:0030335 positive regulation of cell migration BCL2, DRD1, F10, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.73993
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ALOX15, BCL2, CDC25B, CHRNA3, CHRNA7, ESR1, F3, FLT3, GRM1, GRM5, GSK3B, HMGCR, KDR, MMP9, PTGS2, PTPN1, SRC, XDH 2.73993
[BP] GO:0007193 None ADORA1, GRM1, GRM3, GRM5, GRM8 2.73993
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HMGCR, MMP2, MMP9, PTGS2 2.73993
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, CYP1A1, CYP1B1, DRD1, ESR1, FLT3, PTGS2, RORC, SRC 2.73993
[BP] GO:0009115 None AOX1, XDH 2.73993
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, DRD1, F10, FLT3, GSK3B, IGF1R, KDR, MET, SRC, TNKS, TOP1 2.72938
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, SLC1A1 2.72359
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AURKB, BCL2, CYP1A1, EDNRA, ESR1, FLT3, MET, PIM1, SRC, TYR 2.70293
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.68976
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AOX1, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, GAA, GBA2, GSK3B, IDO1, MGAM, XDH 2.67375
[BP] GO:0051338 regulation of transferase activity ADORA1, AURKB, CDC25B, CHRNA3, CHRNA7, FABP4, FLT3, GRM1, GRM5, GSK3B, HMGCR, IGF1R, PTPN1, SRC, TNKS 2.67142
[BP] GO:0097756 None ADORA1, EDNRA, HMGCR, PTGS2 2.66678
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FLT3, HMGCR, PPARA, PTGS2, RORC, SRC 2.65088
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ADORA1, ALOX15, AXL, BCL2, CA2, CA7, CHRNA3, CYP19A1, DRD1, GRIK5, GRM5, GSK3B, HMGCR, MMP12, MMP9, PPARA, PTGS2, PTPN1, SRC 2.65088
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, BCL2, DRD1, ESR1, ESR2, GSK3B, HMGCR, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, PTPRS, SRC, XDH 2.65088
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, AURKB, BCL2, CDC25B, CHRNA3, CHRNA7, DHFR, EDNRA, ESR1, F3, FLT3, GRM1, GRM5, GSK3B, PTPN1, SRC, TNKS, XDH 2.65088
[BP] GO:2000147 positive regulation of cell motility BCL2, DRD1, F10, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.64728
[BP] GO:0016310 phosphorylation AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD1, FLT3, GSK3B, IGF1R, KDR, MET, PIM1, SRC, TNKS, TOP1 2.64248
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, BCL2, DRD1, ESR1, ESR2, GSK3B, HMGCR, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, PTPRS, SRC, XDH 2.64096
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CHRNA7, CSNK2A1, CYP1B1, ESR1, ESR2, F10, F3, FLT3, GRM1, GSK3B, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PTGS2, PTPN1, PTPRS, SRC, TNKS, TNKS2, XDH 2.64096
[BP] GO:0044070 regulation of anion transport ABCB1, ADORA1, CA2, CA7, GRM5 2.62081
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.62081
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CDK6, CYP1B1, DRD1, KDR, PTGS2, SRC 2.6192
[BP] GO:0043393 regulation of protein binding AURKB, BCL2, GSK3B, MET, MMP9, PPARA, SRC 2.61471
[BP] GO:0006811 None ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRNA3, CHRNA7, DRD1, FABP3, GRIA2, GRIA4, GRIK5, PPARA, SLC1A1 2.59036
[BP] GO:0031324 negative regulation of cellular metabolic process AURKB, BCL2, CHRNA7, CSNK2A1, DHFR, EDNRA, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, GSK3B, HMGCR, IGF1R, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 2.58455
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, DRD1, KDR, SRC 2.58155
[BP] GO:0051272 positive regulation of cellular component movement BCL2, DRD1, F10, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.5696
[BP] GO:0007268 None CHRNA3, DRD1, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 2.52939
[BP] GO:0098916 None CHRNA3, DRD1, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 2.52939
[BP] GO:0032845 None ADORA1, BCL2, HMGCR, SRC, TNKS, TNKS2 2.52518
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ALOX15, AURKB, BCL2, CA9, CDC25B, CDK6, CHRNA3, CHRNA7, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DHFR, DRD1, EDNRA, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, GSK3B, HMGCR, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP1, XDH 2.4793
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.47002
[BP] GO:0099536 None CHRNA3, DRD1, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 2.47002
[BP] GO:0099537 None CHRNA3, DRD1, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 2.47002
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.47002
[BP] GO:0019372 lipoxygenase pathway ALOX15, ALOX5, PTGS2 2.47002
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, FLT3, HSD11B2, PTGS2, SRC 2.46372
[BP] GO:0040017 positive regulation of locomotion BCL2, DRD1, F10, F3, IGF1R, KDR, MET, MMP9, PTGS2, SRC 2.46372
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ALOX15, BCL2, CDC25B, CHRNA3, CHRNA7, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PTGS2, PTPN1, SRC, XDH 2.4449
[BP] GO:0043436 oxoacid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, GBA2, IDO1, PIM1, PPARA, PTGS2, TYR 2.44317
[BP] GO:0022414 reproductive process AKR1B1, ALPL, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, DRD1, ESR1, ESRRB, HSD11B2, HSD17B2, IDO1, MMP2, MMP9, PTGS2, SRC 2.40774
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.40209
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, PTGS2, TNKS, TNKS2 2.39164
[BP] GO:0043065 positive regulation of apoptotic process BCL2, CYP1B1, F3, GRIK5, GSK3B, HMGCR, IDO1, MMP9, PTGS2, SRC, XDH 2.38279
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, FLT3, HSD11B2, PTGS2, SRC 2.38279
[BP] GO:0003018 None ADORA1, DRD1, EDNRA, HMGCR, PTGS2, SRC 2.38279
[BP] GO:0006082 organic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, DHFR, FABP3, GBA2, IDO1, PIM1, PPARA, PTGS2, TYR 2.38279
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, MMP9, PTGS2, PTPN1, SRC 2.38279
[BP] GO:0007188 None ADORA1, DRD1, GRM1, GRM3, GRM5, GRM8 2.38279
[BP] GO:0099566 None GRM1, GRM5 2.38279
[BP] GO:0000023 None GAA, MGAM 2.38279
[BP] GO:0046110 None AOX1, XDH 2.38279
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.38279
[BP] GO:1905144 None CHRNA3, CHRNA7 2.38279
[BP] GO:0010906 None ESRRB, GSK3B, PPARA, RORC, SRC 2.37081
[BP] GO:0043068 positive regulation of programmed cell death BCL2, CYP1B1, F3, GRIK5, GSK3B, HMGCR, IDO1, MMP9, PTGS2, SRC, XDH 2.37081
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.35596
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, CHRNA7, FLT3, GRM1, HMGCR, KDR, PTPN1, SRC, XDH 2.34096
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.33129
[BP] GO:0010038 response to metal ion ALOX15, BCL2, CA2, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.32374
[BP] GO:0044248 cellular catabolic process ACHE, AKR1B10, AOX1, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, GAA, GBA2, GSK3B, IDO1, MGAM, SRC, XDH 2.30984
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, IDO1, XDH 2.30778
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, ESR1, HMGCR, IGF1R, MET, MMP9, PTGS2, PTPN1, SRC, XDH 2.30778
[BP] GO:0001101 response to acid chemical AKR1B1, DHFR, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC 2.3028
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.29916
[BP] GO:0007154 None ADORA1, AXL, BCL2, CHRNA3, DRD1, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, PTGS2, SLC1A1 2.27216
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.25742
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, CDK6, GSK3B, KDR, SRC 2.24958
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CYP1A1, HMGCR, HSD11B2, PTGS2, SRC, TYR 2.18916
[BP] GO:0006091 generation of precursor metabolites and energy AKR1B1, AOX1, CYP19A1, CYP1A2, GAA, GSK3B, IDO1, XDH 2.18726
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.18111
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4 2.17877
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.17877
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.17877
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.16475
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.16475
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, MMP9, SRC 2.16443
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, CHRNA7, FLT3, GRM1, HMGCR, IGF1R, PTPN1, SRC 2.16443
[BP] GO:0051098 regulation of binding AURKB, BCL2, GSK3B, MET, MMP9, PPARA, SRC, TNKS 2.1396
[BP] GO:0070213 None TNKS, TNKS2 2.1396
[BP] GO:0006145 None AOX1, XDH 2.1396
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.1396
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.13728
[BP] GO:0010942 positive regulation of cell death BCL2, CYP1B1, F3, GRIK5, GSK3B, HMGCR, IDO1, MMP9, PTGS2, SRC, XDH 2.13435
[BP] GO:0007626 None CHRNA3, DRD1, GAA, GRM1, GRM5, IDO1 2.11506
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TNKS, TNKS2 2.11342
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, ESR1, FABP4, IDO1, MMP12, MMP2, PPARA, PTGS2, PTPN1, PTPRS, SRC 2.1006
[BP] GO:0050801 ion homeostasis BCL2, CA12, CA2, CA7, CHRNA7, DRD1, EDNRA, ESR1, FABP3, GRM1, GRM5 2.09645
[BP] GO:0045859 regulation of protein kinase activity ADORA1, CDC25B, CHRNA3, CHRNA7, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, PTPN1, SRC 2.09426
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.09259
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.09259
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, MMP2, MMP9 2.0891
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP3A4, RORC 2.0891
[BP] GO:0031399 regulation of protein modification process ADORA1, ALOX15, BCL2, CDC25B, CHRNA3, CHRNA7, DRD1, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MMP9, PTGS2, PTPN1, SRC, XDH 2.08498
[BP] GO:0007187 None ADORA1, DRD1, GRM1, GRM3, GRM5, GRM8 2.07834
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.04244
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.04235
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, CHRNA3, CHRNA7, FLT3, GRM1, GRM5, PTPN1, SRC, TNKS 2.021
[BP] GO:0010810 regulation of cell-substrate adhesion ALOX15, BCL2, CDK6, GSK3B, KDR, SRC 2.02087
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.00959
[CC] GO:0098590 plasma membrane region ABCB1, ADORA1, CA2, CA4, CA9, CHRNA3, CHRNA7, DRD1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, MET, MGAM, PTGS2, SLC1A1, SRC 5.76304
[CC] GO:0005886 plasma membrane ABCB1, ACHE, ADORA1, ADORA3, ALOX15, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CHRNA3, CHRNA7, CSNK2A1, DRD1, EDNRA, ESR1, F10, F3, FLT3, GAA, GBA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, GSK3B, IGF1R, KDR, MET, MGAM, MMP2, PIM1, PTPN1, PTPRS, SLC1A1, SRC 4.66553
[CC] GO:0016020 membrane ABCB1, ACHE, ADORA1, ADORA3, ALOX15, ALOX5, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRNA3, CHRNA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, EDNRA, ESR1, F10, F3, FLT3, FUT7, GAA, GBA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, GSK3B, HMGCR, HSD11B1, HSD11B2, HSD17B2, IGF1R, KDR, MET, MGAM, MMP2, PIM1, PTGS2, PTPN1, PTPRS, SLC1A1, SRC, TNKS, TNKS2, TYR 4.59561
[CC] GO:0044459 plasma membrane part ABCB1, ADORA1, ADORA3, ALOX15, AXL, CA2, CA4, CA9, CHRNA3, CHRNA7, DRD1, EDNRA, F10, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MGAM, PTGS2, PTPRS, SLC1A1, SRC 4.35425
[CC] GO:0044456 None ACHE, ADORA1, CHRNA3, CHRNA7, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, GSK3B, PTPRS, SRC 3.69268
[CC] GO:0044425 membrane part ABCB1, ACHE, ADORA1, ADORA3, ALOX15, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRNA3, CHRNA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, EDNRA, ESR1, F10, F3, FLT3, FUT7, GBA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSD11B1, HSD11B2, HSD17B2, IGF1R, KDR, MET, MGAM, PTGS2, PTPN1, PTPRS, SLC1A1, SRC, TYR 3.31789
[CC] GO:0097060 None CHRNA3, CHRNA7, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 3.31789
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 3.11004
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, AXL, CA4, DRD1, EDNRA, F10, F3, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, PTPRS, SLC1A1 2.96083
[CC] GO:0043226 organelle ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA2, CA4, CA9, CBR1, CDK6, CHRNA3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DHFR, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GAA, GBA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GSK3B, HMGCR, IDO1, IGF1R, KDR, MGAM, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SLC1A1, SRC, TNKS, TNKS2, TOP1, TUBB3, TYR, XDH 2.74711
[CC] GO:0014069 None ADORA1, CHRNA3, GRIK5, GRM1, GRM3, GRM5, SRC 2.67746
[CC] GO:0099572 None ADORA1, CHRNA3, GRIK5, GRM1, GRM3, GRM5, SRC 2.67746
[CC] GO:0044432 endoplasmic reticulum part BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, F10, FLT3, GBA2, GRIA2, HMGCR, HSD11B1, HSD11B2, HSD17B2, PTGS2, PTPN1 2.63049
[CC] GO:0043005 None ADORA1, CA2, CHRNA3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PTGS2, PTPRS, SRC, TUBB3 2.58807
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, GBA2, GRIA2, HMGCR, HSD11B1, HSD11B2, HSD17B2, PTGS2 2.56771
[CC] GO:0098794 None ADORA1, CHRNA7, GRIA2, GRIA4, GRM3, GSK3B 2.41573
[CC] GO:0043227 membrane-bounded organelle ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA2, CA4, CBR1, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DHFR, DRD1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GAA, GBA2, GRIA4, GRIK5, GRM1, GRM5, GSK3B, HMGCR, IGF1R, KDR, MGAM, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SLC1A1, SRC, TNKS, TNKS2, TOP1, TUBB3, TYR, XDH 2.37081
[CC] GO:0031233 None CA4, F10, F3 2.23576
[CC] GO:0098802 None CHRNA3, CHRNA7, GRIA2, GRIA4, GRIK5, GRM1 2.16443
[CC] GO:0120025 None ADORA1, AKR1B1, CA2, CDK6, CHRNA3, DRD1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PTGS2, PTPRS, SRC, TUBB3 2.13143
[CC] GO:0044464 cell part ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CHRNA3, CHRNA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DHFR, DRD1, EDNRA, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GAA, GBA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, GSK3B, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, MET, MGAM, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SLC1A1, SRC, TNKS, TNKS2, TOP1, TUBB3, TYR, XDH 2.02087
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, TNKS, TYR, XDH 11.8584
[MF] GO:0003824 catalytic activity ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DHFR, EDNRA, F10, F3, FLT3, FUT7, GAA, GBA2, GSK3B, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, IGF1R, KDR, MET, MGAM, MMP1, MMP12, MMP2, MMP9, PIM1, PTGS2, PTPN1, PTPRS, SRC, TNKS, TNKS2, TOP1, TUBB3, TYR, XDH 11.6314
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDK6, CHRNA3, CHRNA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DHFR, DRD1, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GSK3B, HMGCR, HSD17B1, IDO1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SLC1A1, SRC, TNKS, TNKS2, TOP1, TUBB3, TYR, XDH 10.2368
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.48694
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DHFR, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IDO1, PTGS2, TYR, XDH 8.42791
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.63781
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, CHRNA3, CHRNA7, DRD1, EDNRA, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, PPARA, RORC 6.63179
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, CBR1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 6.56798
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, CDK6, CHRNA3, CHRNA7, DRD1, EDNRA, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, PPARA, RORC 6.14924
[MF] GO:0005496 steroid binding CYP3A4, ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, RORC 5.77631
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, CHRNA3, CHRNA7, DRD1, EDNRA, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, PPARA, RORC 5.77631
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.76304
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC, TNKS 5.50519
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DHFR, HMGCR, HSD11B2, HSD17B1, IDO1, PTGS2, SRC, XDH 5.21161
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, AOX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CHRNA3, CHRNA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD1, ESR1, ESR2, ESRRA, ESRRB, F10, IDO1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC1A1, TNKS, TNKS2, TYR, XDH 5.11033
[MF] GO:0030594 None CHRNA3, CHRNA7, DRD1, GRIA2, GRIA4, GRIK5, GRM1, GRM5 5.10167
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, CHRNA3, CHRNA7, DRD1, EDNRA, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, PPARA, RORC 5.06415
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, XDH 5.02052
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 4.97575
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 4.90784
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.90021
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.75038
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.75038
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, IDO1, PTGS2, SRC 4.69472
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 4.67503
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CDK6, CHRNA3, CHRNA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DHFR, DRD1, FLT3, GSK3B, IGF1R, KDR, MET, PIM1, PPARA, SRC, TOP1 4.53699
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, IDO1, PTGS2, SRC 4.50961
[MF] GO:0008289 lipid binding ALOX15, AXL, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, HSD11B2, HSD17B1, PPARA, RORC 4.47541
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.39957
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, CHRNA3, CHRNA7, DRD1, EDNRA, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET 3.80201
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, CHRNA3, CHRNA7, DRD1, EDNRA, F3, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET 3.80201
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 3.6774
[MF] GO:0098960 None CHRNA3, CHRNA7, GRM1, GRM5 3.5755
[MF] GO:0005231 None CHRNA3, CHRNA7, GRIA2, GRIA4, GRIK5 3.56014
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, AOX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, IDO1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC1A1, TNKS, TNKS2, TYR, XDH 3.53885
[MF] GO:0022824 None CHRNA3, CHRNA7, GRIA2, GRIA4, GRIK5 3.49752
[MF] GO:0022835 None CHRNA3, CHRNA7, GRIA2, GRIA4, GRIK5 3.49752
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TYR 3.36289
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX15, ALOX5, IDO1, PTGS2 3.25457
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, PTGS2, TYR 3.25433
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.21113
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX15, ALOX5, IDO1, PTGS2 3.21113
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.13333
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.11004
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, IDO1, XDH 3.10915
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.10915
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 2.83756
[MF] GO:0005230 None CHRNA3, CHRNA7, GRIA2, GRIA4, GRIK5 2.74711
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.73993
[MF] GO:0003845 None HSD11B1, HSD11B2 2.73993
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, MET, PIM1, SRC, TOP1 2.70748
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.67454
[MF] GO:0015926 None GAA, GBA2, MGAM 2.62081
[MF] GO:0042562 hormone binding ACHE, CHRNA3, CHRNA7, HSD17B1, IGF1R 2.56496
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.50214
[MF] GO:0043168 anion binding ABCB1, ALOX15, AOX1, AURKB, AXL, CDK6, CSNK2A1, DHFR, F10, F3, FABP3, FABP4, FLT3, GSK3B, HMGCR, HSD17B1, IGF1R, KDR, MET, PIM1, PTPRS, SLC1A1, SRC, TOP1, TUBB3, XDH 2.46358
[MF] GO:0042166 None ACHE, CHRNA3, CHRNA7 2.40209
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.38279
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.38279
[MF] GO:0032450 None GAA, MGAM 2.38279
[MF] GO:0099583 None GRM1, GRM5 2.38279
[MF] GO:0036094 small molecule binding ABCB1, ADORA1, AOX1, AURKB, AXL, CDK6, CSNK2A1, DHFR, FABP3, FABP4, FLT3, GSK3B, HMGCR, HSD11B2, HSD17B1, IGF1R, KDR, MET, PIM1, SLC1A1, SRC, TOP1, TUBB3, XDH 2.3133
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.29916
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.29916
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.1396
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.1396
[MF] GO:0004971 None GRIA2, GRIA4 2.1396
[MF] GO:0004558 None GAA, MGAM 2.1396
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.1396
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CSNK2A1, FLT3, GSK3B, IGF1R, KDR, MET, PIM1, SRC, TOP1 2.11348
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.09529


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 8.8374
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 9.8055
Metabolic pathways_Homo sapiens_hsa01100 CBR1, MGAM, GAA, ALOX15, AKR1B1, HMGCR, PTGS2, TYR, CYP3A4, GBA2, CYP19A1, DHFR, HSD11B1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH, IDO1 8.4827
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 10.3297
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GRIA2, CHRNA3, CHRNA7, GRIK5, GRM1, GRM3, GRM5, EDNRA, ADORA3, GRM8, ADORA1, DRD1, GRIA4 8.4827
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, GRM1, GRIA4 6.2863
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CHRNA7, CYP1A2, CYP1A1, CYP1B1, PTGS2, CYP3A4 7.3622
Pathways in cancer_Homo sapiens_hsa05200 GSK3B, EDNRA, CDK6, FLT3, MMP1, MMP2, BCL2, PTGS2, MMP9, MET, IGF1R 4.967
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 4.967
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1, IDO1 4.967
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, GRM1, ESR2 4.3113
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, ABCB1, BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET, CDC25B 4.3113
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, IGF1R 3.6552
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 3.8049
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, PTGS2, GRM1, GRIA4 3.2599
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, TUBB3, DRD1, GRM1 3.5227
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 3.6096
cAMP signaling pathway_Homo sapiens_hsa04024 GRIA2, EDNRA, ADORA1, DRD1, PPARA, GRIA4 2.8965
Focal adhesion_Homo sapiens_hsa04510 GSK3B, SRC, KDR, BCL2, MET, IGF1R 2.8925
Galactose metabolism_Homo sapiens_hsa00052 MGAM, AKR1B10, GAA, AKR1B1 4.0722
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, PTGS2 2.9714
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1, CYP3A4 2.914
Prolactin signaling pathway_Homo sapiens_hsa04917 GSK3B, SRC, ESR1, ESR2 2.8595
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, PIM1, F3 2.3433
Calcium signaling pathway_Homo sapiens_hsa04020 GRM5, EDNRA, CHRNA7, DRD1, GRM1 2.3171
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2, HMGCR, CYP3A4 2.862
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 2.8925
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, CHRNA3, CHRNA7, BCL2 2.2332
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 GSK3B, CDK6, KDR, BCL2, MET, IGF1R 1.9385
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, GSK3B, DRD1, GRIA4 2.0441
Hepatitis B_Homo sapiens_hsa05161 CDK6, SRC, BCL2, MMP9 1.9311
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, GRM8, GRM1 1.9378
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1, PTGS2 2.1142
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1, IGF1R 2.0441
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR, PTGS2 2.0439
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, DRD1, GRIA4 1.9504
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, GRM1 1.9574
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2, DRD1 2.2426
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.6527
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, CHRNA7, GRIA4 2.4574
Prostate cancer_Homo sapiens_hsa05215 GSK3B, BCL2, IGF1R 1.6844
Melanoma_Homo sapiens_hsa05218 CDK6, MET, IGF1R 1.9311
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, MET, IGF1R 1.475
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, AOX1, CYP3A4 1.9378
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2, PTGS2 1.7165
Insulin resistance_Homo sapiens_hsa04931 PTPN1, GSK3B, PPARA 1.4951
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2 1.6498
Serotonergic synapse_Homo sapiens_hsa04726 ALOX5, ALOX15, PTGS2 1.475
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 GSK3B, SRC, ESR1 1.4262
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.2404
Measles_Homo sapiens_hsa05162 GSK3B, CDK6, CSNK2A1 1.2958
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.4143
Cell cycle_Homo sapiens_hsa04110 GSK3B, CDK6, CDC25B 1.3838
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 GSK3B, ESRRB, IGF1R 1.2575
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1 1.184
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 EDNRA, ADORA3, ADORA1 1.1472
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4 2.8595
Epstein-Barr virus infection_Homo sapiens_hsa05169 GSK3B, CSNK2A1, BCL2 0.9702
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 0.8841
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.7765
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 0.9062
HTLV-I infection_Homo sapiens_hsa05166 GSK3B 0.1832
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.1834
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 0.9523
TNF signaling pathway_Homo sapiens_hsa04668 PTGS2, MMP9 0.8447
Melanogenesis_Homo sapiens_hsa04916 GSK3B, TYR 0.8962
ErbB signaling pathway_Homo sapiens_hsa04012 GSK3B, SRC 0.9706
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.2262
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2, IGF1R 0.8841
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, GRIA4 0.9248
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 0.9523
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.2524
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2619
Neurotrophin signaling pathway_Homo sapiens_hsa04722 GSK3B, BCL2 0.8041
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.8069
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2711
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.2778
AMPK signaling pathway_Homo sapiens_hsa04152 HMGCR, IGF1R 0.7846
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2 0.8069
Alcoholism_Homo sapiens_hsa05034 DRD1 0.2688
FoxO signaling pathway_Homo sapiens_hsa04068 GRM1, IGF1R 0.7565
Influenza A_Homo sapiens_hsa05164 GSK3B 0.2711
Alzheimer's disease_Homo sapiens_hsa05010 GSK3B 0.2778
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, GSK3B 0.7378
Hepatitis C_Homo sapiens_hsa05160 GSK3B, PPARA 0.7565
Hippo signaling pathway_Homo sapiens_hsa04390 GSK3B 0.3008
Axon guidance_Homo sapiens_hsa04360 GSK3B, MET 0.7765
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.7378
Parkinson's disease_Homo sapiens_hsa05012 DRD1 0.318
Phagosome_Homo sapiens_hsa04145 TUBB3 0.3008
Wnt signaling pathway_Homo sapiens_hsa04310 GSK3B, CSNK2A1 0.7324
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2 0.3077
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 GSK3B, PPARA 0.6998
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.6062
Apoptosis_Homo sapiens_hsa04210 BCL2 0.3198
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, PTGS2 0.6761
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.0443
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, SRC 0.5564
Chemokine signaling pathway_Homo sapiens_hsa04062 GSK3B, SRC 0.5911
Lysosome_Homo sapiens_hsa04142 GAA 0.3594
Platelet activation_Homo sapiens_hsa04611 SRC 0.3594
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3594
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.1472
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 1.04
Vascular smooth muscle contraction_Homo sapiens_hsa04270 EDNRA 0.3594
Glioma_Homo sapiens_hsa05214 CDK6, IGF1R 1.1652
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.2328
T cell receptor signaling pathway_Homo sapiens_hsa04660 GSK3B 0.4051
Colorectal cancer_Homo sapiens_hsa05210 GSK3B, BCL2 1.1844
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4124
Renin secretion_Homo sapiens_hsa04924 EDNRA, ADORA1 1.1715
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.42
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.425
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.4257
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4244
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.1471
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4382
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4382
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4382
Taste transduction_Homo sapiens_hsa04742 GRM1 0.4519
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4382
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.218
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.4382
Starch and sucrose metabolism_Homo sapiens_hsa00500 MGAM, GAA 1.2404
Peroxisome_Homo sapiens_hsa04146 XDH 0.4519
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6 0.4896
B cell receptor signaling pathway_Homo sapiens_hsa04662 GSK3B 0.4896
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2, BCL2 1.2958
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.4896
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.4877
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.4954
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.4974
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5109
Pancreatic cancer_Homo sapiens_hsa05212 CDK6 0.5109
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5109
Shigellosis_Homo sapiens_hsa05131 SRC 0.5109
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.5109
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP3A4, XDH 1.3662
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6 0.5564
Endometrial cancer_Homo sapiens_hsa05213 GSK3B 0.5709
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 TUBB3 0.5564
Basal cell carcinoma_Homo sapiens_hsa05217 GSK3B 0.5564
Malaria_Homo sapiens_hsa05144 MET 0.5867
Hedgehog signaling pathway_Homo sapiens_hsa04340 GSK3B 0.5825
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.5308
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.5918
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 MGAM 0.6014
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.5911
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.5918
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.5156
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.6062
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.5977
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2 0.6465
African trypanosomiasis_Homo sapiens_hsa05143 IDO1 0.6819
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.8339
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7231
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7378
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7565
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7324
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.754
Folate biosynthesis_Homo sapiens_hsa00790 DHFR, ALPL 2.133
One carbon pool by folate_Homo sapiens_hsa00670 DHFR 0.8271
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 HMGCR 0.8041
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.8611
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 2.8965
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.218


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)