Prescription Description
| Prescription ID | TCMF315 |
| Pinyin Name | Zhi Hong Chang Pi Wan |
| Chinese Name | 止红肠辟丸 |
| English Name | Zhi Hong Chang Pi Pills |
| Function Description | 痔疮 |
| Indications | Hemorrhoids |
| Disease ICD-11 Category |
DB60 [Haemorrhoids, 痔
]; |
| Human Tissues Associated with Indication | Large Intestine |
| Reference | Chinese pharmacopoeia (2015) |
| Reference Book/link | ISBN 978-7-5067-7337-9 |
Prescription Components
| Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
|---|---|---|---|---|
| TCMH451 | Rehmannia glutinosa | 地黄 | TCMH451 | ITSAH4578-14 |
| TCMH986 | Scutellaria baicalensis | 黄芩 | TCMH986 | ITSAP4211-14 |
| TCMH2641 | Gardenia jasminoides | 栀子 | TCMH2641 | ITSAJ4473-14 |
| TCMH938 | Sophora japonica | 槐花 | TCMH938 | ITSAN2377-14 |
| TCMH1142 | Schizonepetae spica | 荆芥穗 | TCMH1142 | |
| TCMH972 | Coptis chinensis | 黄连 | TCMH972 | ITSAO4469-14 |
| TCMH1906 | Cimicifuga foetida | 升麻 | TCMH1906 | |
| TCMH421 | Angelica sinensis | 当归 | TCMH421 | ITSAF173-14 |
| TCMH463 | Sanguisorba officinalis | 地榆炭 | TCMH463 | GENG545-14, GBVT2403-13 |
| TCMH104 | Paeonia lactiflora | 白芍 | TCMH104 | ITSAH2416-14 |
| TCMH541 | Colla corii asini | 阿胶 | TCMH541 | |
| TCMH223 | Platycladus orientalis | 侧柏炭 | TCMH223 | ITSAJ4756-14 |
| TCMH2191 | Prunus mume | 乌梅 | TCMH2191 | ITSAN1052-14 |
Targeted Human Proteins by the Ingredients of Prescription
| Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
|---|---|---|---|---|
| TCMT100 | TTR | Transthyretin | Unclassified | P02766 |
| TCMT102 | ACP1 | Low molecular weight phosphotyrosine protein phosphatase | Hydrolase | P24666 |
| TCMT103 | PTPRF | Receptor-type tyrosine-protein phosphatase F (LAR) | Hydrolase | P10586 |
| TCMT112 | ADORA3 | Adenosine A3 receptor | GPCR | P0DMS8 |
| TCMT126 | TERT | Telomerase reverse transcriptase | Transferase | O14746 |
| TCMT127 | PARP1 | Poly [ADP-ribose] polymerase-1 | Transferase | P09874 |
| TCMT128 | TNKS2 | Tankyrase-2 | Transferase | Q9H2K2 |
| TCMT129 | TNKS | Tankyrase-1 | Transferase | O95271 |
| TCMT13 | APEX1 | DNA-(apurinic or apyrimidinic site) lyase | Lyase | P27695 |
| TCMT130 | ALOX5 | Arachidonate 5-lipoxygenase | Oxidoreductase | P09917 |
Showing 1 to 10 of 111 entries
Targeted Pathogenic Microbes by the Ingredients of Prescription
| Target ID | Target Name |
|---|---|
| TCMT1175 | Human immunodeficiency virus |
| TCMT1176 | Streptococcus pneumoniae |
| TCMT1178 | Actinomyces viscosus |
| TCMT1189 | Pseudomonas fluorescens |
| TCMT1190 | Plasmodium falciparum (isolate FcB1 / Columbia) |
| TCMT1191 | Bacillus megaterium |
| TCMT1208 | Escherichia coli K12 |
| TCMT1212 | Verticillium dahliae |
| TCMT1213 | Neisseria gonorrhoeae |
| TCMT1214 | Enterococcus faecium |
Showing 1 to 10 of 67 entries
Gene Ontology Associated to Targeted Human Proteins
| GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|---|
| [BP] GO:0000302 | response to reactive oxygen species | AKR1B1, APEX1, AXL, BCL2, CYP1B1, MMP9, SRC | 3.20487 |
| [BP] GO:0001503 | ossification | ALOX15, ALPL, BCL2, MMP2, MMP9 | 2.16882 |
| [BP] GO:0001666 | response to hypoxia | ADORA1, BCL2, CYP1A1, MMP2, PPARA, SRC, TERT | 2.26089 |
| [BP] GO:0001676 | long-chain fatty acid metabolic process | ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 | 4.56474 |
| [BP] GO:0002320 | lymphoid progenitor cell differentiation | BCL2, FLT3, KIT | 2.93396 |
| [BP] GO:0002521 | leukocyte differentiation | AXL, BCL2, FLT3, FUT7, GLO1, KIT, MMP9, RORC | 3.05836 |
| [BP] GO:0006082 | organic acid metabolic process | ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GLO1, PIM1, PPARA, TYR | 2.24964 |
| [BP] GO:0006145 | None | AOX1, XDH | 2.10952 |
| [BP] GO:0006367 | transcription initiation from RNA polymerase II promoter | ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC | 2.45591 |
| [BP] GO:0006468 | protein phosphorylation | APP, AURKB, AXL, BCL2, CSNK2A1, DRD1, DYRK1A, FLT3, IGF1R, KDR, KIT, MET, PIM1, SRC, TNKS | 3.54809 |
Showing 1 to 10 of 251 entries
KEGG Pathways Associated to Targeted Human Proteins
| KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|
| ABC transporters_Homo sapiens_hsa02010 | ABCB1 | 0.586 |
| Acute myeloid leukemia_Homo sapiens_hsa05221 | FLT3, KIT, PIM1 | 2.1718 |
| Adherens junction_Homo sapiens_hsa04520 | CSNK2A1, SRC, MET, IGF1R | 2.9374 |
| Adipocytokine signaling pathway_Homo sapiens_hsa04920 | PPARA | 0.495 |
| Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | BCL2 | 0.3421 |
| AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | MMP2, BCL2, PIM1, F3 | 2.46 |
| Alcoholism_Homo sapiens_hsa05034 | DRD1 | 0.3034 |
| Alzheimer's disease_Homo sapiens_hsa05010 | BACE1, APP | 0.6469 |
| Amphetamine addiction_Homo sapiens_hsa05031 | DRD1 | 0.5072 |
| AMPK signaling pathway_Homo sapiens_hsa04152 | IGF1R | 0.3653 |
Showing 1 to 10 of 136 entries
Target Exprsssion in Healthy Human Tissues (protein & mRNA level)
Protein expression data was from the "Human Proteome Map" datasetmRNA expression data was from the "GTEx" dataset
Average Target Expression (Fold Change) in Multiple Disease Conditions
Fold Change with Corresponding Normal SamplesClick each cell within the heatmap to access gene expression of individual patient samples