TCM Prescription: Lifting and Benefiting Decoction



Prescription Description
Prescription IDTCMF1840
Pinyin NameSheng Yi Xuan Hua Tang
Chinese Name
English NameLifting and Benefiting Decoction
Function Description
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH981 Astragalus membranaceus 黄芪 TCMH981 ITSAK2981-14
TCMH120 Atractylodes macrocephala 白术 TCMH120 ITSAN4430-14
TCMH2728 Aster tataricus 紫菀 TCMH2728 ITSAI2445-14
TCMH1906 Cimicifuga foetida 升麻 TCMH1906
TCMH241 Plantago asiatica 车前子 TCMH241 ITSAB3641-14
TCMH1742 Cinnamomum cassia 肉桂 TCMH1742 GQ255631
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT151 PRKCA Protein kinase C alpha Kinase P17252
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1191 Bacillus megaterium
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1243 Aspergillus flavus
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1319 Corynebacterium xerosis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, APP, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, PPARA, PRKCA, RORC, SMAD3, SRC, TEK, TYR 9.81355
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, BCL2, CDC25B, CSNK2A1, CYP1B1, EGFR, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, PIM1, PRKCA, SMAD3, SRC, TEK, XDH 9.08533
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 9.08533
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 9.08533
[BP] GO:0042221 response to chemical AKR1B1, ALPL, APP, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, PPARA, PRKCA, RORC, SMAD3, SRC, TEK, TYR 8.7079
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APP, AXL, BCL2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, HSD17B2, IGF1R, INSR, MMP2, MMP9, PPARA, RORC, SRC, TEK, TYR 8.64146
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, TYR, XDH 8.18716
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PRKCA, PTPN1, SMAD3, SRC, TEK 8.08807
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PRKCA, PTPN1, SMAD3, SRC, TEK 7.78914
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PRKCA, PTPN1, SRC, TEK, XDH 7.57888
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, APP, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 7.41845
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, MET, PPARA 7.41845
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.41845
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, NUAK1, PIM1, PPARA, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, TYR, XDH 7.23438
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, FABP3, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 7.20541
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AXL, BCL2, CYP1B1, EGFR, FLT3, GPR35, HSPA1A, INSR, KDR, MET, PRKCA, PTPN1, SRC, TEK, XDH 7.14954
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, SMAD3, SRC, TEK 7.11828
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MMP9, PIM1, PRKCA, PTPN1, SMAD3, SRC, TEK 7.10835
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 7.08742
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP4, FLT3, FUT7, HSD17B2, INSR, KDR, MET, MMP2, MMP9, PIM1, PPARA, PRKCA, RORC, SMAD3, SRC, TEK, TYR 7.06379
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, FLT3, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 6.96517
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 6.93521
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, MMP9, PRKCA, SMAD3, SRC, TEK 6.85541
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, EGFR, FABP3, FABP4, FLT3, GPR35, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MET, PPARA, PRKCA, SMAD3, SRC, TEK, XDH 6.77283
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, FLT3, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 6.77283
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 6.69858
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, HSPA1A, PIM1, PPARA, TYR, XDH 6.69858
[BP] GO:0010035 response to inorganic substance AKR1B1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, MMP9, SRC 6.69858
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK 6.67078
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 6.61495
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 6.59279
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, MMP9, PRKCA, SMAD3, SRC, TEK 6.5642
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PTPN1, SRC, TEK, XDH 6.4743
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 6.45883
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, FABP3, FLT3, HSD17B2, RORC, SRC, TYR 6.41567
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, APP, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, FABP4, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP12, MMP2, MMP9, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 6.41567
[BP] GO:0014070 response to organic cyclic compound ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FLT3, RORC, SRC, TEK, TYR 6.39952
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PRKCA, PTPN1, SRC, TEK 6.39952
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, PRKCA, PTPN1, SMAD3, SRC, TEK 6.27292
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APP, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, RORC, SMAD3, SRC 6.24764
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PTPN1, SRC, TEK, XDH 6.18211
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, MMP9, PRKCA, SMAD3, SRC, TEK 6.18211
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, FLT3, HSPA1A, IGF1R, KDR, MMP9, PIM1, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 6.18211
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, MMP9, PRKCA, SMAD3, SRC, TEK 6.16969
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, FLT3, HSD17B2, INSR, KDR, PPARA, SMAD3, SRC, TEK, TYR 6.16699
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 6.07846
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, FABP3, FLT3, INSR, PPARA, SRC, TEK 6.0443
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 6.03729
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, EGFR, IGF1R, INSR, KDR, MET, MMP9, PRKCA, SMAD3, SRC, TEK 6.03309
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, PPARA, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, TYR 6.00973
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, APP, BCL2, CDC25B, DUSP3, EGFR, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, NUAK1, PPARA, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 6.00462
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP4, HSD17B2, IGF1R, INSR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TYR 5.97578
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PRKCA, PTPN1, SMAD3, SRC, TEK 5.96956
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, APP, BCL2, CDC25B, DUSP3, EGFR, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, NUAK1, PPARA, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 5.96245
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, EGFR, IGF1R, INSR, KDR, MET, MMP9, PRKCA, SMAD3, SRC, TEK 5.90757
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, EGFR, IGF1R, INSR, KDR, MET, MMP9, PRKCA, SMAD3, SRC, TEK 5.77792
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, PTPN1, RORC, SMAD3, SRC 5.69274
[BP] GO:0080134 regulation of response to stress ADORA1, APP, CYP19A1, DUSP3, EGFR, FABP4, HSPA1A, IGF1R, MET, MMP12, MMP2, NUAK1, PPARA, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 5.68623
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, EGFR, IGF1R, INSR, KDR, MET, MMP9, PRKCA, SMAD3, SRC, TEK 5.62482
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK 5.60355
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, PIM1, PRKCA, TEK 5.43846
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, APP, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FLT3, HSD17B2, INSR, KDR, MMP9, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TYR 5.32196
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APP, AXL, BCL2, CYP1A1, CYP1B1, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MMP2, RORC, SMAD3, SRC 5.27375
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AURKB, AXL, BCL2, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, TYR, XDH 5.23244
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2 5.1483
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP2, MMP9, NUAK1, PPARA, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 5.09551
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, APP, BCL2, CDC25B, EGFR, FABP3, FLT3, INSR, KDR, MMP9, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 5.06971
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, APP, BCL2, CDC25B, EGFR, FABP3, FLT3, INSR, KDR, MMP9, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 5.06971
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 5.04761
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, CYP1A1, CYP1A2, DUSP3, EGFR, FLT3, FUT7, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PRKCA, PTPN1, SMAD3, SRC, TEK, TYR, XDH 4.97473
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, MET, MMP9, NUAK1, PIM1, PPARA, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 4.9676
[BP] GO:0043408 regulation of MAPK cascade ADORA1, APP, DUSP3, EGFR, FLT3, IGF1R, INSR, KDR, PRKCA, PTPN1, SRC, TEK, XDH 4.79047
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, EGFR, HSPA1A, MMP2, PPARA, SMAD3, SRC, TEK, TYR 4.7902
[BP] GO:0042325 regulation of phosphorylation ADORA1, APP, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, PPARA, PRKCA, PTPN1, SRC, TEK, XDH 4.78457
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, DUSP3, FABP4, GPR35, IGF1R, MET, MMP9, PIM1, PPARA, PRKCA, PTPN1, SRC 4.77055
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, AURKB, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, MMP9, NUAK1, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 4.75206
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.70964
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APP, AXL, BCL2, CA12, CA2, CA7, EGFR, FABP3, FABP4, FLT3, GPR35, INSR, MET, SMAD3, SRC 4.6581
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, GPR35, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 4.60359
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, APP, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, PRKCA, PTPN1, SRC, TEK, XDH 4.58047
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AURKB, AXL, BCL2, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, TYR, XDH 4.52711
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, BCL2, CA1, CSNK2A1, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, MET, MMP2, MMP9, PRKCA, PTPN1, SMAD3, SRC, TEK 4.52711
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, APP, EGFR, FLT3, INSR, KDR, PRKCA, PTPN1, SRC, TEK, XDH 4.51801
[BP] GO:0031399 regulation of protein modification process ADORA1, APP, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PRKCA, PTPN1, SRC, TEK, XDH 4.50251
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 4.36498
[BP] GO:0007346 regulation of mitotic cell cycle APP, AURKB, BCL2, CDC25B, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, PRKCA, SMAD3 4.34632
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, APP, BCL2, CDC25B, EGFR, FLT3, INSR, KDR, MMP9, PRKCA, PTPN1, SRC, TEK, XDH 4.32537
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, HSPA1A, MMP1, MMP12, MMP2, MMP9, SRC, XDH 4.2857
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 4.24383
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FUT7, MET, PPARA 4.23852
[BP] GO:0051049 regulation of transport ACHE, ADORA1, APP, AXL, BCL2, CA2, CA7, CYP19A1, EGFR, GPR35, HSPA1A, INSR, MMP12, MMP9, PPARA, PRKCA, PTPN1, SMAD3, SRC 4.21401
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, APP, BCL2, CDC25B, EGFR, FLT3, INSR, KDR, MMP9, PRKCA, PTPN1, SRC, TEK, XDH 4.11624
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, AXL, BCL2, CYP1B1, EGFR, HSPA1A, MMP9, SRC 4.08432
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, EGFR, MMP9, SRC 3.99186
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.98142
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 3.98142
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.98142
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, MMP2, PPARA, SMAD3, SRC, TEK 3.97237
[BP] GO:0009611 response to wounding ACHE, ADORA3, BCL2, CYP1A1, EGFR, PPARA, SMAD3 3.93498
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, PRKCA, SRC, TEK 3.9314
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, MMP2, PPARA, SMAD3, SRC, TEK 3.89081
[BP] GO:0001503 ossification ALPL, BCL2, EGFR, MMP2, MMP9, TEK 3.87525
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.86567
[BP] GO:0045787 positive regulation of cell cycle APP, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, INSR, PRKCA, SRC 3.86567
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade APP, DUSP3, EGFR, KDR, PRKCA, PTPN1, SRC, TEK 3.83042
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, SRC, TEK, TYR 3.78811
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 3.73831
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, APP, BCL2, CDC25B, CSNK2A1, EGFR, FLT3, HSPA1A, INSR, KDR, MMP9, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 3.73704
[BP] GO:0019538 protein metabolic process ACHE, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, FUT7, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PRKCA, PTPN1, SMAD3, SRC, TEK 3.71805
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, GPR35, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, PIM1, PPARA, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 3.70581
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, APP, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 3.70063
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, EGFR, HSD17B1, HSD17B2, PRKCA 3.69899
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PRKCA, SRC, TEK 3.68352
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, MMP2, PPARA, SMAD3, SRC, TEK 3.66366
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, EGFR, FABP4, HSPA1A, MMP12, MMP2, PPARA, PTPN1, SMAD3, SRC, TEK 3.65863
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, BCL2, CA12, CA2, CA7, EGFR, FABP3, FABP4, GPR35, INSR, MET, SMAD3 3.63712
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, BCL2, DUSP3, EGFR, GPR35, HSPA1A, IGF1R, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, XDH 3.62755
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, BCL2, DUSP3, EGFR, GPR35, HSPA1A, IGF1R, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, XDH 3.61891
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC 3.61891
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CYP1A1, EGFR, FLT3, MET, PIM1, SRC, TEK, TYR 3.61891
[BP] GO:0001775 cell activation ALOX5, APP, AXL, BCL2, EGFR, FLT3, FUT7, HSPA1A, MMP9, PRKCA, RORC, SMAD3, SRC 3.57937
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, BCL2, CYP19A1, DUSP3, EGFR, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 3.56646
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, INSR, MET, SRC, TEK, XDH 3.54784
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 3.50679
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, SRC, TEK, TYR 3.50371
[BP] GO:0009893 positive regulation of metabolic process ADORA1, APP, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 3.46645
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, APP, AURKB, BCL2, CDC25B, EGFR, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 3.46645
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.46142
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, APP, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PPARA, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 3.43204
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, APP, BCL2, CDC25B, EGFR, FLT3, HSPA1A, INSR, KDR, MMP9, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 3.42395
[BP] GO:0010038 response to metal ion APP, BCL2, CA2, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 3.42395
[BP] GO:0051726 regulation of cell cycle APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, PRKCA, SMAD3, SRC 3.42395
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AXL, BCL2, CA2, CYP1B1, EGFR, HSPA1A, KDR, MET, MMP12, MMP9, PIM1, PRKCA, SMAD3, SRC, TEK 3.42031
[BP] GO:0051130 positive regulation of cellular component organization APP, AURKB, AXL, BCL2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, SMAD3, SRC, TEK 3.40774
[BP] GO:0045931 positive regulation of mitotic cell cycle APP, CDC25B, CYP1A1, DUSP3, INSR, PRKCA 3.39544
[BP] GO:0043549 regulation of kinase activity ADORA1, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, PTPN1, SRC, TEK 3.3839
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, PTPN1, SRC, TEK 3.35559
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, INSR, MET, SRC, TEK 3.27018
[BP] GO:0031401 positive regulation of protein modification process ADORA1, APP, BCL2, CDC25B, EGFR, FLT3, INSR, KDR, MMP9, PRKCA, PTPN1, SRC, TEK, XDH 3.26676
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, FLT3, IGF1R, INSR, PTPN1, SRC 3.24765
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, MET, MMP9, PPARA, SMAD3, SRC 3.22217
[BP] GO:0048732 gland development BCL2, CSNK2A1, CYP19A1, EGFR, INSR, SMAD3, TYR 3.21442
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, APP, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 3.19833
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, IGF1R, INSR, PPARA, SRC, TEK 3.1745
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2, TYR, XDH 3.17276
[BP] GO:0044267 cellular protein metabolic process ALPL, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, FUT7, IGF1R, INSR, KDR, MET, MMP1, MMP2, NUAK1, PIM1, PRKCA, PTPN1, SMAD3, SRC, TEK 3.16729
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APP, CYP1A1, CYP1B1, EGFR, FLT3, RORC, SRC 3.16628
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 3.14727
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, APP, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, HSPA1A, MMP2, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK 3.14163
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 3.12293
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AXL, CYP1B1, EGFR, IGF1R, INSR, MMP2, MMP9, RORC, SRC 3.12293
[BP] GO:0009894 regulation of catabolic process ADORA1, BCL2, CSNK2A1, EGFR, HSPA1A, INSR, KDR, MET, PPARA, PRKCA, PTPN1, SMAD3 3.10212
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MMP9, PTPN1, SRC 3.0967
[BP] GO:0010638 positive regulation of organelle organization AURKB, BCL2, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.09515
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FLT3, PPARA, RORC, SRC, TEK 3.08344
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, EGFR, INSR, SMAD3, XDH 3.06396
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1 3.06396
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, MMP12, PPARA, SMAD3, TEK 3.03725
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, EGFR, FABP4, KDR, MET, MMP12, PPARA, PRKCA, SMAD3, TEK 2.99385
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.99385
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.99385
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.99385
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.99385
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR 2.97515
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, PTPN1, SRC 2.97308
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.972
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, KDR, SMAD3, SRC, TEK 2.96102
[BP] GO:0006690 icosanoid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1 2.94271
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, APP, AXL, BCL2, CA2, CYP19A1, EGFR, INSR, MMP12, SMAD3, SRC 2.92082
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DUSP3, HSPA1A, IGF1R, MET, MMP9, PTPN1, SRC, XDH 2.89564
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.89317
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.87561
[BP] GO:0002009 morphogenesis of an epithelium BCL2, CA2, CA9, EGFR, MET, SMAD3, SRC 2.8703
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, APP, AXL, BCL2, CA2, CYP1B1, EGFR, GPR35, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PIM1, PRKCA, SMAD3, SRC, TEK, XDH 2.85915
[BP] GO:0006464 cellular protein modification process ALPL, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, FUT7, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PTPN1, SMAD3, SRC, TEK 2.85915
[BP] GO:0036211 protein modification process ALPL, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, FUT7, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PTPN1, SMAD3, SRC, TEK 2.85915
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, EGFR, PPARA, RORC, SRC 2.85915
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CBR1, CYP1A1, CYP1A2, CYP1B1, EGFR, HSPA1A 2.8424
[BP] GO:0030155 regulation of cell adhesion BCL2, CYP1B1, DUSP3, KDR, NUAK1, PPARA, PRKCA, SMAD3, SRC, TEK 2.8424
[BP] GO:0044093 positive regulation of molecular function ADORA1, APP, AURKB, BCL2, CDC25B, EGFR, FLT3, HSPA1A, INSR, MET, MMP9, PTPN1, SMAD3, SRC, TEK, XDH 2.84106
[BP] GO:0048869 cellular developmental process ACHE, ALPL, APP, AXL, BCL2, CBR1, CDC25B, CYP1A1, EGFR, FABP4, FLT3, FUT7, KDR, MET, MMP2, MMP9, RORC, SMAD3, SRC, TEK 2.83721
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1B1, KDR, SRC 2.83068
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, EGFR, HSD17B2, INSR, MMP2, MMP9, SRC 2.81663
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.81663
[BP] GO:0019369 arachidonic acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1 2.81663
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.81663
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, PPARA, SMAD3, TEK 2.77548
[BP] GO:0006631 fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA 2.76502
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade APP, EGFR, KDR, PRKCA, SRC, TEK 2.76081
[BP] GO:0051246 regulation of protein metabolic process ADORA1, APP, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 2.76041
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 2.7582
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, TYR 2.7582
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APP, AURKB, BCL2, CSNK2A1, DUSP3, EGFR, FABP4, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PRKCA, PTPN1, RORC, SMAD3, SRC, XDH 2.74532
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.73812
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.73811
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, EGFR 2.68768
[BP] GO:0030198 extracellular matrix organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.6731
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.67191
[BP] GO:0043062 extracellular structure organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.66778
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, APP, AXL, BCL2, CA1, CA2, CSNK2A1, CYP1B1, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, MET, MMP2, MMP9, NUAK1, PIM1, PPARA, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK 2.66517
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, SRC, TEK 2.66436
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, KDR, SRC 2.65566
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.64169
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, GPR35, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, TYR, XDH 2.64169
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.63779
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, APP, AURKB, BCL2, CDC25B, EGFR, FLT3, HSPA1A, INSR, PTPN1, SMAD3, SRC, TEK, XDH 2.63315
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.62785
[BP] GO:0010632 regulation of epithelial cell migration KDR, MET, MMP9, PRKCA, SRC, TEK 2.59084
[BP] GO:0032872 regulation of stress-activated MAPK cascade APP, DUSP3, EGFR, IGF1R, PTPN1, XDH 2.59084
[BP] GO:0070302 regulation of stress-activated protein kinase signaling cascade APP, DUSP3, EGFR, IGF1R, PTPN1, XDH 2.58127
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, SRC 2.58012
[BP] GO:0042493 response to drug AKR1B1, AXL, BCL2, CA9, CYP1A1, CYP1B1, EGFR, FABP3, KDR, SRC 2.55801
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, EGFR, FLT3, SRC 2.55611
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.55611
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.52428
[BP] GO:0050678 None EGFR, KDR, MMP12, PRKCA, SMAD3, TEK, XDH 2.52251
[BP] GO:0031099 regeneration AXL, BCL2, CSNK2A1, EGFR, FLT3 2.49268
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIM1, PPARA, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 2.49268
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, BCL2, CDC25B, CYP19A1, EGFR, HSD17B2, INSR, SRC 2.49268
[BP] GO:0051894 None KDR, SMAD3, TEK 2.48051
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.48051
[BP] GO:0050730 None ADORA1, APP, EGFR, FLT3, PTPN1, SRC 2.44516
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.42873
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, EGFR, KDR, SRC 2.40551
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.40551
[BP] GO:1903393 None KDR, SMAD3, TEK 2.38904
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.38904
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIM1, PPARA, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 2.38904
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIM1, PPARA, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 2.36963
[BP] GO:0009653 anatomical structure morphogenesis APP, AXL, BCL2, CA2, CA9, CYP1B1, EGFR, INSR, MET, MMP2, SMAD3, SRC, TEK 2.36963
[BP] GO:0048729 tissue morphogenesis BCL2, CA2, CA9, EGFR, MET, SMAD3, SRC 2.35743
[BP] GO:0044089 positive regulation of cellular component biogenesis HSPA1A, KDR, MET, MMP1, PRKCA, SMAD3, SRC, TEK 2.35273
[BP] GO:0035556 intracellular signal transduction AKR1B1, AXL, BCL2, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, NUAK1, PRKCA, PTPN1, SRC, TEK 2.35125
[BP] GO:0071248 cellular response to metal ion CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.35125
[BP] GO:0002682 regulation of immune system process ADORA1, APP, AXL, BCL2, CA2, CYP19A1, DUSP3, HSPA1A, MMP12, MMP2, PRKCA, PTPN1, SMAD3, SRC 2.35057
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIM1, PPARA, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 2.33998
[BP] GO:0031100 animal organ regeneration AXL, CSNK2A1, EGFR, FLT3 2.33821
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9 2.33821
[BP] GO:0071363 cellular response to growth factor stimulus APP, EGFR, INSR, KDR, SMAD3, SRC 2.33617
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.27684
[BP] GO:0080135 regulation of cellular response to stress APP, DUSP3, EGFR, HSPA1A, IGF1R, MET, NUAK1, PTPN1, XDH 2.27406
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, EGFR, FLT3, SRC 2.27406
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1 2.27406
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, DUSP3, EGFR, FLT3, IGF1R, INSR, PTPN1, SRC 2.27087
[BP] GO:0090087 None ACHE, ADORA1, APP, CA2, EGFR, MMP12, PRKCA, PTPN1, SMAD3, SRC 2.26291
[BP] GO:0032963 collagen metabolic process MMP1, MMP12, MMP2, MMP9 2.24768
[BP] GO:2001242 regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MMP9, PTPN1, SRC 2.24197
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, SRC, TEK 2.24031
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR 2.24031
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, TYR 2.23409
[BP] GO:1901888 regulation of cell junction assembly KDR, SMAD3, SRC, TEK 2.23409
[BP] GO:0043412 macromolecule modification ALPL, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, FUT7, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, PTPN1, SMAD3, SRC, TEK 2.22529
[BP] GO:0009968 negative regulation of signal transduction BCL2, DUSP3, EGFR, HSPA1A, IGF1R, MET, MMP12, MMP9, PTPN1, SMAD3, SRC, XDH 2.21639
[BP] GO:0002521 leukocyte differentiation AXL, BCL2, FLT3, FUT7, MMP9, RORC 2.21373
[BP] GO:1901890 None KDR, SMAD3, TEK 2.20976
[BP] GO:0071276 cellular response to cadmium ion CYP1A2, EGFR, MMP9 2.20976
[BP] GO:0051704 multi-organism process APP, AXL, BCL2, CYP1A1, EGFR, HSPA1A, INSR, KDR, MET, MMP1, MMP12, SMAD3, SRC 2.20507
[BP] GO:0009895 negative regulation of catabolic process ADORA1, BCL2, EGFR, MET, PPARA, SMAD3 2.2035
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, APP, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIM1, PPARA, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 2.2035
[BP] GO:0050801 ion homeostasis APP, BCL2, CA12, CA2, CA7, EGFR, FABP3, GPR35, SMAD3 2.20201
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, EGFR, FLT3, INSR, PTPN1, SRC 2.19762
[BP] GO:0010595 positive regulation of endothelial cell migration KDR, MET, PRKCA, TEK 2.19355
[BP] GO:0016477 cell migration AXL, CYP1B1, EGFR, FUT7, KDR, MMP1, MMP12, MMP9, SRC, TEK 2.19355
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7 2.1803
[BP] GO:0042058 None ADORA1, APP, EGFR, MMP9 2.17848
[BP] GO:0044259 multicellular organismal macromolecule metabolic process MMP1, MMP12, MMP2, MMP9 2.17848
[BP] GO:0050727 regulation of inflammatory response ADORA1, CYP19A1, EGFR, FABP4, PPARA, SMAD3, TEK 2.1779
[BP] GO:0048534 hematopoietic or lymphoid organ development BCL2, FLT3, KDR, TEK, TYR 2.16194
[BP] GO:0048608 reproductive structure development AXL, BCL2, CYP19A1, HSD17B2, INSR, SRC 2.15629
[BP] GO:0040011 locomotion AXL, CYP1B1, EGFR, FUT7, KDR, MET, MMP1, MMP12, MMP9, SRC, TEK 2.15317
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APP, EGFR, FLT3, IGF1R, INSR, MMP2, SMAD3, SRC 2.15317
[BP] GO:0090218 positive regulation of lipid kinase activity FLT3, SRC, TEK 2.15317
[BP] GO:0010907 None INSR, PPARA, SRC 2.15317
[BP] GO:0106027 None APP, IGF1R, INSR 2.15317
[BP] GO:0046328 regulation of JNK cascade APP, DUSP3, EGFR, IGF1R, PTPN1 2.14693
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, EGFR, FLT3, INSR, PTPN1, SRC, TEK 2.14693
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APP, EGFR, IGF1R, INSR, MMP2, SRC 2.1429
[BP] GO:0007155 cell adhesion ACHE, APP, AXL, BCL2, CYP1B1, EGFR, NUAK1, PRKCA, SRC, TEK 2.14144
[BP] GO:0051902 negative regulation of mitochondrial depolarization BCL2, SRC 2.13184
[BP] GO:1990535 None APP, INSR 2.13184
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, INSR, SMAD3, XDH 2.12416
[BP] GO:0022610 biological adhesion ACHE, APP, AXL, BCL2, CYP1B1, EGFR, NUAK1, PRKCA, SRC, TEK 2.12416
[BP] GO:0071241 cellular response to inorganic substance CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.12397
[BP] GO:0032989 cellular component morphogenesis APP, AXL, BCL2, EGFR, MET, SRC, TEK 2.11519
[BP] GO:0032103 positive regulation of response to external stimulus EGFR, FABP4, KDR, MET, PRKCA, SMAD3 2.1044
[BP] GO:0070848 response to growth factor APP, EGFR, INSR, KDR, SMAD3, SRC 2.1044
[BP] GO:0050679 None EGFR, KDR, MMP12, PRKCA, TEK 2.09507
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, EGFR, FLT3, INSR, PTPN1, SRC, TEK 2.08687
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, EGFR, KDR, SRC 2.08687
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, APP, BCL2, CYP1B1, FABP3, HSPA1A, SMAD3, XDH 2.08687
[BP] GO:0051128 regulation of cellular component organization APP, AURKB, AXL, BCL2, CSNK2A1, EGFR, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, PTPN1, SMAD3, SRC, TEK 2.08687
[BP] GO:1901654 None AKR1B1, CA9, CSNK2A1, EGFR, SRC 2.0695
[BP] GO:0045124 None CA2, EGFR, SRC 2.0695
[BP] GO:0010906 None INSR, PPARA, RORC, SRC 2.03561
[BP] GO:0051248 None APP, CSNK2A1, DUSP3, EGFR, FABP4, HSPA1A, IGF1R, MMP9, PTPN1, SMAD3, SRC, XDH 2.02863
[BP] GO:0014066 regulation of phosphatidylinositol 3-kinase signaling EGFR, FLT3, KDR, TEK 2.02353
[BP] GO:0016101 None AKR1B10, CYP1A1, CYP1B1, EGFR 2.02353
[BP] GO:0051094 positive regulation of developmental process APP, AXL, BCL2, CA2, CYP1B1, INSR, KDR, PIM1, PRKCA, SMAD3, SRC, TEK 2.02353
[BP] GO:0010564 regulation of cell cycle process APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1A1, EGFR, HSPA1A, INSR 2.02353
[BP] GO:1904180 negative regulation of membrane depolarization BCL2, SRC 2.01757
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, TEK 2.8703
[CC] GO:0005783 None ADORA1, APP, BCL2, CA4, CYP19A1, FLT3, HSPA1A, KDR, PRKCA, PTPN1, XDH 2.39919
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, MET, MMP2, PIM1, PRKCA, PTPN1, SMAD3, SRC, TEK 2.38904
[CC] GO:0048471 perinuclear region of cytoplasm ACHE, AKR1B1, APP, CA4, EGFR, HSPA1A, PRKCA, SRC, TYR 2.28056
[CC] GO:0097443 sorting endosome KDR, PTPN1 2.13184
[CC] GO:0045121 membrane raft APP, EGFR, INSR, KDR, SRC, TEK 2.012
[MF] GO:0046914 transition metal ion binding ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PRKCA, PTPN1, RORC, SMAD3, TYR, XDH 11.4654
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PRKCA, PTPN1, SRC, TEK, TYR, XDH 10.7556
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.3883
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, TYR, XDH 8.79578
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.96063
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.25372
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.91185
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.18211
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 6.16699
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK 6.07969
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, PRKCA, SRC, TEK 6.03729
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, MMP1, MMP12, MMP2, MMP9, PPARA, PRKCA, PTPN1, RORC, SMAD3 5.90757
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK 5.21184
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC 4.87157
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK 4.78888
[MF] GO:0032403 protein complex binding ACHE, ADORA1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC 4.35544
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PRKCA, PTPN1, RORC, SMAD3, TYR, XDH 4.21955
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 4.04057
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK 4.01302
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PRKCA, PTPN1, SRC, TEK 3.9703
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2, TYR, XDH 3.9463
[MF] GO:0046872 metal ion binding ALOX5, ALPL, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PRKCA, PTPN1, RORC, SMAD3, TYR, XDH 3.87525
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 3.87217
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.87086
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.58931
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, CBR1, HSD17B1, HSD17B2, XDH 3.50679
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR 3.28463
[MF] GO:0036094 small molecule binding ADORA1, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK, XDH 3.25723
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 3.16729
[MF] GO:0019902 phosphatase binding BCL2, EGFR, MET, PPARA, PTPN1, SMAD3 3.12027
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 3.0967
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.06396
[MF] GO:0005524 ATP binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK 3.02314
[MF] GO:0032559 adenyl ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK 2.92477
[MF] GO:0030554 adenyl nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK 2.89564
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HSD17B1, HSD17B2 2.72078
[MF] GO:0043168 anion binding APP, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK, XDH 2.66517
[MF] GO:0005518 collagen binding ACHE, MMP12, MMP9, SMAD3 2.5953
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC 2.5953
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.57164
[MF] GO:0000166 nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK, XDH 2.51887
[MF] GO:1901265 nucleoside phosphate binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK, XDH 2.51789
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC 2.46916
[MF] GO:0051425 None APP, INSR 2.42873
[MF] GO:0097367 carbohydrate derivative binding ADORA1, APP, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK 2.37088
[MF] GO:0043548 phosphatidylinositol 3-kinase binding AXL, IGF1R, INSR 2.27406
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 2.27406
[MF] GO:0043559 insulin binding IGF1R, INSR 2.25228
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, MET, PPARA, RORC, TEK 2.23358
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.20976
[MF] GO:0035639 purine ribonucleoside triphosphate binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK 2.19629
[MF] GO:0004064 arylesterase activity CA1, CA2 2.13184
[MF] GO:0032555 purine ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK 2.11519
[MF] GO:0017076 purine nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK 2.08898
[MF] GO:0032553 ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK 2.08687
[MF] GO:0005021 vascular endothelial growth factor-activated receptor activity FLT3, KDR 2.01757
[MF] GO:0001609 None ADORA1, ADORA3 2.01757


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 10.1893
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.672
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 8.9385
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, PRKCA, MMP9, MET, EGFR, IGF1R 5.7296
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, FLT3, MMP1, MMP2, BCL2, PRKCA, MMP9, MET, EGFR, IGF1R 5.7296
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 6.3738
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KDR, PRKCA, TEK, MET, EGFR, IGF1R 5.7296
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 5.7296
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, BCL2, PRKCA, TEK, EGFR, IGF1R 5.218
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, PRKCA, MET, EGFR, IGF1R 4.7445
MicroRNAs in cancer_Homo sapiens_hsa05206 BCL2, PIM1, CYP1B1, PRKCA, MMP9, MET, EGFR, CDC25B 4.7445
Ras signaling pathway_Homo sapiens_hsa04014 INSR, KDR, PRKCA, TEK, MET, EGFR, IGF1R 4.479
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 INSR, KDR, BCL2, PRKCA, TEK, MET, EGFR, IGF1R 4.3711
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 4.1686
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, MMP2, BCL2, PIM1, PRKCA 4.1121
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, EGFR, HSPA1A 4.1266
Metabolic pathways_Homo sapiens_hsa01100 CBR1, AKR1B1, TYR, CYP19A1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH 3.7488
Hepatitis B_Homo sapiens_hsa05161 SMAD3, SRC, BCL2, PRKCA, MMP9 3.4351
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CBR1, CYP1A2, CYP1A1, CYP1B1 3.4351
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, PRKCA, EGFR 3.1299
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.4946
Chemical carcinogenesis_Homo sapiens_hsa05204 CBR1, CYP1A2, CYP1A1, CYP1B1 3.2859
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, PRKCA, EGFR, CDC25B, HSPA1A 2.469
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1, PRKCA 2.7036
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, EGFR, IGF1R 2.5588
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR, PRKCA 2.469
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, ADORA1 2.5588
Glioma_Homo sapiens_hsa05214 PRKCA, EGFR, IGF1R 2.4288
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 2.4342
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.1898
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.9423
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET, EGFR 2.4041
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 2.357
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, PRKCA, EGFR 2.1337
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.3987
Prostate cancer_Homo sapiens_hsa05215 BCL2, EGFR, IGF1R 2.1333
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, BCL2, PRKCA 1.902
Gap junction_Homo sapiens_hsa04540 SRC, PRKCA, EGFR 2.1337
Insulin resistance_Homo sapiens_hsa04931 PTPN1, INSR, PPARA 1.9045
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5, PRKCA 1.902
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2, HSPA1A 1.8576
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.7326
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, PRKCA, MMP9 1.8576
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1, PRKCA 1.6792
Phospholipase D signaling pathway_Homo sapiens_hsa04072 INSR, PRKCA, EGFR 1.6708
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, PRKCA, EGFR 1.569
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC, PRKCA 1.6962
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, INSR, ADORA1 1.5275
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2, HSPA1A 1.3717
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GPR35, ADORA3, ADORA1 1.0987
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, PRKCA 1.2052
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.2052
Morphine addiction_Homo sapiens_hsa05032 ADORA1, PRKCA 1.2343
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 1.2207
GABAergic synapse_Homo sapiens_hsa04727 SRC, PRKCA 1.2486
Melanogenesis_Homo sapiens_hsa04916 PRKCA, TYR 1.1949
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 1.2369
Gastric acid secretion_Homo sapiens_hsa04971 CA2, PRKCA 1.3717
Measles_Homo sapiens_hsa05162 CSNK2A1, HSPA1A 0.9974
Choline metabolism in cancer_Homo sapiens_hsa05231 PRKCA, EGFR 1.1927
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 1.2231
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.9374
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, IGF1R 1.0583
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 1.0092
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2, PRKCA 0.9477
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, PRKCA 1.0863
Non-small cell lung cancer_Homo sapiens_hsa05223 PRKCA, EGFR 1.5275
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, IGF1R 0.9743
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, INSR 0.9855
Pancreatic secretion_Homo sapiens_hsa04972 CA2, PRKCA 1.2099
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1 0.9129
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.5275
Cell cycle_Homo sapiens_hsa04110 SMAD3, CDC25B 1.0583
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.3401
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2, HSPA1A 0.8814
Long-term depression_Homo sapiens_hsa04730 PRKCA, IGF1R 1.5002
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, EGFR 1.4571
Calcium signaling pathway_Homo sapiens_hsa04020 PRKCA, EGFR 0.8573
Influenza A_Homo sapiens_hsa05164 PRKCA, HSPA1A 0.8693
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, EGFR 0.753
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.8611
HTLV-I infection_Homo sapiens_hsa05166 SMAD3 0.2972
Colorectal cancer_Homo sapiens_hsa05210 SMAD3, BCL2 1.4877
cAMP signaling pathway_Homo sapiens_hsa04024 ADORA1, PPARA 0.8011
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.4628
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.5065
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1 1.4628
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.3667
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3952
Purine metabolism_Homo sapiens_hsa00230 XDH 0.4093
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3944
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5 1.4877
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.4224
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.4521
Apoptosis_Homo sapiens_hsa04210 BCL2 0.4808
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.4911
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PRKCA 0.4911
Platelet activation_Homo sapiens_hsa04611 SRC 0.5134
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.5166
Axon guidance_Homo sapiens_hsa04360 MET 0.5046
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.5134
Dopaminergic synapse_Homo sapiens_hsa04728 PRKCA 0.5018
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.5399
Glutamatergic synapse_Homo sapiens_hsa04724 PRKCA 0.5296
Vascular smooth muscle contraction_Homo sapiens_hsa04270 PRKCA 0.5166
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.5578
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5658
Amoebiasis_Homo sapiens_hsa05146 PRKCA 0.5658
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PRKCA 0.5784
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PRKCA 0.568
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5766
Circadian entrainment_Homo sapiens_hsa04713 PRKCA 0.5766
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PRKCA 0.5658
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR, PRKCA 1.7804
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5919
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.5977
Salivary secretion_Homo sapiens_hsa04970 PRKCA 0.5919
Insulin secretion_Homo sapiens_hsa04911 PRKCA 0.5965
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5919
Small cell lung cancer_Homo sapiens_hsa05222 BCL2 0.5953
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 PRKCA 0.6052
Peroxisome_Homo sapiens_hsa04146 XDH 0.5991
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3 0.639
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.9259
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.6409
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PRKCA 0.6457
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.6214
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.6428
Long-term potentiation_Homo sapiens_hsa04720 PRKCA 0.6501
Bile secretion_Homo sapiens_hsa04976 CA2 0.6428
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.6501
Amphetamine addiction_Homo sapiens_hsa05031 PRKCA 0.6478
Thyroid hormone synthesis_Homo sapiens_hsa04918 PRKCA 0.6428
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.6511
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2 0.6434
Shigellosis_Homo sapiens_hsa05131 SRC 0.6501
mTOR signaling pathway_Homo sapiens_hsa04150 PRKCA 0.6731
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.7042
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.719
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 PRKCA 0.7042
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.902
Vibrio cholerae infection_Homo sapiens_hsa05110 PRKCA 0.7228
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.7228
Malaria_Homo sapiens_hsa05144 MET 0.7312
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.8395
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.7354
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 PRKCA 0.7399
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.7445
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.1337
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.8444
African trypanosomiasis_Homo sapiens_hsa05143 PRKCA 0.8444
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.9069
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8693
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.8444
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.8821
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.9129
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8771
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.9069
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.1123
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.2859


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)