TCM Prescription: Plus and Minus Eight Pearl Decoction



Prescription Description
Prescription IDTCMF2462
Pinyin NameJia Jian Ba Zhen Tang
Chinese Name加减八珍汤
English NamePlus and Minus Eight Pearl Decoction
Function Description
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1721 Panax ginseng 人参 TCMH1721 GBVE1679-11
TCMH120 Atractylodes macrocephala 白术 TCMH120 ITSAN4430-14
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH1423 Ophiopogon japonicus 麦冬 TCMH1423 ITSAJ4140-14
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH2486 Coix lacryma- jobi var. ma - yuen 薏苡仁 TCMH2486
TCMH943 Rhizoma dioscoreae 淮山药 TCMH943
TCMH1806 Radix glehniae 沙参 TCMH1806
TCMH104 Paeonia lactiflora 白芍 TCMH104 ITSAH2416-14
TCMH407 Salvia miltiorrhiza 丹参 TCMH407 ITSAH2408-14
TCMH1906 Cimicifuga foetida 升麻 TCMH1906
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT126 TERT Telomerase reverse transcriptase Transferase O14746
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT171 PTPN6 Protein-tyrosine phosphatase 1C Hydrolase P29350
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT197 PDE4D Phosphodiesterase 4D Hydrolase Q08499
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT210 CES2 Carboxylesterase 2 Hydrolase O00748
TCMT211 CES1 Acyl coenzyme A:cholesterol acyltransferase Transferase P23141
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT233 PTPN11 Protein-tyrosine phosphatase 2C Hydrolase Q06124
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT247 ADRA2A Alpha-2a adrenergic receptor GPCR P08913
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT307 KCNH2 HERG Ion channel Q12809
TCMT31 CYP2C19 Cytochrome P450 2C19 Oxidoreductase P33261
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT359 FYN Tyrosine-protein kinase FYN Kinase P06241
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT633 SLC6A4 Serotonin transporter Transporter P31645
TCMT634 SLC6A2 Norepinephrine transporter Transporter P23975
TCMT635 SLC6A3 Dopamine transporter Transporter Q01959
TCMT648 DRD4 Dopamine D4 receptor GPCR P21917
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT698 PDE4B Phosphodiesterase 4B Hydrolase Q07343
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT848 ERN1 Serine/threonine-protein kinase/endoribonuclease IRE1 Kinase O75460
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1168 Trichomonas vaginalis
TCMT1170 Enterobacter cloacae
TCMT1172 Staphylococcus aureus subsp. aureus RN4220
TCMT1174 Mycobacterium bovis BCG
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1177 Haemophilus influenzae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1184 Mycobacterium fortuitum
TCMT1185 Mycobacterium phlei
TCMT1186 Plasmodium yoelii yoelii
TCMT1187 Enterococcus faecalis ATCC 29212
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1191 Bacillus megaterium
TCMT1192 Bacteria
TCMT1193 Staphylococcus
TCMT1194 Shigella sonnei
TCMT1196 Salmonella
TCMT1198 Serratia marcescens
TCMT1199 Streptococcus sp. 'group A'
TCMT1200 Bacillus thuringiensis
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1202 Mycoplasma hominis
TCMT1203 Mycoplasma pneumoniae
TCMT1204 Clostridium perfringens
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1216 Vibrio cholerae
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1220 Streptococcus pneumoniae R6
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1244 Staphylococcus saprophyticus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1252 Alcaligenes faecalis
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1262 Mycoplasma putrefaciens
TCMT1266 Mycobacterium abscessus
TCMT1267 Mycobacterium chelonae
TCMT1271 Shigella flexneri
TCMT1272 Campylobacter jejuni
TCMT1273 Pseudomonas putida
TCMT1274 Shigella boydii
TCMT1276 Klebsiella
TCMT1277 Serratia
TCMT1278 Pseudomonas
TCMT1281 Clostridium difficile
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1287 Bacillus subtilis subsp. spizizenii ATCC 6633
TCMT1289 Shigella dysenteriae
TCMT1290 Acinetobacter calcoaceticus
TCMT1291 Haemophilus parainfluenzae
TCMT1292 Japanese encephalitis virus
TCMT1294 Human parainfluenza virus 3
TCMT1299 Morganella morganii
TCMT1300 Enterobacter
TCMT1301 Klebsiella sp.
TCMT1303 Bacillus
TCMT1304 Staphylococcus capitis
TCMT1305 Salmonella enteritidis
TCMT1307 Penicillium marneffei
TCMT1309 Aspergillus clavatus
TCMT1310 Enterococcus hirae
TCMT1314 Streptococcus viridans
TCMT1315 Streptococcus sp.
TCMT1317 Staphylococcus lentus
TCMT1321 Staphylococcus hominis
TCMT1322 Streptococcus mitis
TCMT1326 Shigella
TCMT1331 Acinetobacter sp.
TCMT1332 Bacillus licheniformis
TCMT1334 Chlamydia trachomatis
TCMT1336 Yellow fever virus
TCMT1337 Dengue virus type 4
TCMT1338 Rift Valley fever virus
TCMT1340 Staphylococcus faecalis
TCMT1341 Streptococcus oralis
TCMT1342 Streptococcus salivarius
TCMT1345 Prevotella loescheii
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1355 Rhodococcus equi
TCMT1356 Campylobacter coli
TCMT1358 Bacteroides vulgatus
TCMT1361 Neisseria meningitidis
TCMT1362 Bordetella pertussis
TCMT1363 Peptostreptococcus anaerobius
TCMT1366 Prevotella bivia
TCMT1371 Veillonella parvula
TCMT1375 Clostridium tetani
TCMT1377 Staphylococcus lugdunensis
TCMT1378 Acinetobacter haemolyticus
TCMT1381 Listeria innocua
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1383 Streptomyces griseus
TCMT1388 Prevotella disiens
TCMT1389 Klebsiella oxytoca
TCMT1393 Vibrio sp.
TCMT1394 Mycobacterium aurum
TCMT1395 Staphylococcus sp.
TCMT1396 Fusobacterium
TCMT1399 Chlamydophila pneumoniae
TCMT1400 Mycobacterium mageritense
TCMT1401 Staphylococcus warneri
TCMT1402 Staphylococcus cohnii
TCMT1403 Streptococcus constellatus
TCMT1404 Streptococcus intermedius
TCMT1405 Penicillium citrinum
TCMT1406 Mycobacterium leprae
TCMT1407 Aeromonas punctata
TCMT1408 Colletotrichum gloeosporioides
TCMT1409 Escherichia coli O157:H7
TCMT1410 Listeria monocytogenes
TCMT1411 Vibrio parahaemolyticus
TCMT1412 Salmonella typhimurium
TCMT1413 Vibrio splendidus
TCMT1414 Vibrio vulnificus
TCMT1415 Vibrio fluvialis
TCMT1416 Plesiomonas shigelloides
TCMT1417 Aeromonas sobria
TCMT1418 Enterobacteriaceae
TCMT1420 Klebsiella pneumoniae subsp. ozaenae
TCMT1421 Vibrio mimicus
TCMT1422 Clostridium histolyticum
TCMT1423 Peptostreptococcus
TCMT1424 Haemophilus ducreyi
TCMT1425 Moraxella bovis
TCMT1427 Proteus inconstans
TCMT1429 Acinetobacter pittii
TCMT1431 Coxiella burnetii
TCMT1432 Serratia sp.
TCMT1434 Plesiomonas
TCMT1435 Corynebacterium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1460 Mycobacterium intracellulare
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRA2A, AKR1B1, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CYP19A1, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, INSR, KCNH2, KDR, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, SLC1A1, SLC6A2, SLC6A3, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 14.8632
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD2, EGFR, ESR1, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 12.1537
[BP] GO:0042221 response to chemical ADRA2A, AKR1B1, ALPL, AXL, BCL2, CA2, CA9, CDK6, CES1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD11B2, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MMP2, MMP9, PIK3CA, PPARA, PTGS2, RORC, SLC6A2, SLC6A3, SLC6A4, SMAD3, SRC, TEK, TERT, TYR 11.8743
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA2A, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, EGFR, F10, F3, FLT3, GPR35, GRM1, HCAR2, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 11.6614
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA2A, AKR1B1, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, EGFR, F10, F3, FLT3, GPR35, GRM1, HCAR2, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 11.6605
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, AXL, BCL2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, EGFR, ESR1, ESRRA, FABP3, GRIK5, GRM5, HSD11B2, HSD17B2, IGF1R, INSR, MMP2, MMP9, PIK3CA, PPARA, PTGS2, RORC, SLC6A3, SLC6A4, SRC, TEK, TYR 11.6554
[BP] GO:0010033 response to organic substance ADRA2A, AKR1B1, ALPL, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD11B2, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, PIK3CA, PPARA, PTGS2, RORC, SLC6A3, SLC6A4, SMAD3, SRC, TEK, TYR 11.5582
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.6526
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TYR 10.002
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA2A, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 10.002
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CES1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP2D6, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 9.91521
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA2A, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 9.87415
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 9.87415
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA2A, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, EGFR, F10, F3, FLT3, GPR35, GRM1, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 9.87415
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA2A, AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, ESR1, ESRRA, F3, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, PIM1, PTGS1, PTGS2, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 9.77317
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, FABP3, FUT7, GBA2, HSPA1A, PIK3CA, PIM1, PPARA, PTGS1, PTGS2, TYR, XDH 9.21407
[BP] GO:0014070 response to organic cyclic compound ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, EGFR, ESR1, ESRRA, FLT3, HSD11B2, PTGS2, RORC, SLC6A3, SLC6A4, SRC, TEK, TYR 9.12581
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA2A, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FLT3, GPR35, GRIK5, GRM1, GRM5, HCAR2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 8.97968
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A3, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TYR, XDH 8.89279
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, PTGS1, PTGS2 8.84418
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRA2A, AKR1B1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GPR35, GRIK5, GRM1, GRM5, HCAR2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC1A1, SLC6A3, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 8.63726
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA2A, AKR1B1, AKR1B10, ALOX5, ALPL, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESRRB, F10, F3, FABP4, GRM1, GRM5, GRM8, HSD11B2, HSD17B2, IGF1R, INSR, KCNH2, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RORC, SLC6A2, SLC6A3, SLC6A4, SMAD3, SRC, TEK, TNKS2, TYR 8.59599
[BP] GO:0006690 icosanoid metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, PTGS1, PTGS2 8.57957
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, PTGS1, PTGS2 8.44017
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CES1, CES2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD2, EGFR, FABP3, FABP4, FUT7, GBA2, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 8.44017
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA2A, AKR1B1, AXL, BCL2, CYP1B1, DRD2, DRD4, EGFR, F10, F3, FLT3, GPR35, GRM1, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 8.33931
[BP] GO:0006805 xenobiotic metabolic process CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2C19, CYP2D6, NQO2, PTGS1, RORC 8.21167
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA2A, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, F10, F3, FLT3, GPR35, GRM1, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 8.02248
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, ALPL, AURKB, AXL, BCL2, CA2, CA6, CA9, CDK6, CES1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, EGFR, ESR1, ESRRA, F10, F3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HSD11B2, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A2, SLC6A3, SLC6A4, SMAD3, SRC, TEK, TERT, TYR 7.98517
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA2A, AKR1B1, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, EGFR, ESRRA, F10, F3, FABP4, FLT3, GPR35, GRM1, HSPA1A, INSR, KDR, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 7.98517
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, CA2, CA7, DRD2, DRD3, DRD4, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8, PTGS2, SLC6A4 7.95242
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, CA2, CA7, DRD2, DRD3, DRD4, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8, PTGS2, SLC6A4 7.95242
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD2, DRD3, DRD4, EGFR, GRIK5, INSR, PTGS2, SLC1A1, SLC6A2, SLC6A3, SLC6A4, SMAD3 7.83022
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, DRD3, EGFR, F10, F3, INSR, MET, PIK3CA, PIK3CB, SRC, TEK, XDH 7.7545
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GBA2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP2, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A3, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TYR, XDH 7.75131
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, PTGS2, RORC, SLC6A4, SRC, TYR 7.72227
[BP] GO:0042592 homeostatic process ADORA1, ADRA2A, AKR1B1, AXL, BCL2, CA12, CA2, CA7, DRD2, DRD3, DRD4, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, GRIK5, GRM1, GRM5, INSR, KCNH2, MET, PIK3CA, PIK3CB, SMAD3, SRC, TERT 7.65848
[BP] GO:0009719 response to endogenous stimulus ADRA2A, AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, GRM5, HSD11B2, IGF1R, INSR, MMP2, PPARA, PTGS2, SLC6A4, SMAD3, SRC, TEK 7.64277
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ADRA2A, AXL, BCL2, CA2, CA7, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, EGFR, F10, F3, GPR35, GRIK5, GRM5, HCAR2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP12, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TEK, TERT 7.64078
[BP] GO:0009725 response to hormone ADRA2A, AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, INSR, PPARA, PTGS2, SLC6A4, SRC, TEK 7.59076
[BP] GO:0070887 cellular response to chemical stimulus ADRA2A, AKR1B1, ALPL, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, GRIK5, GRM5, HSPA1A, IGF1R, INSR, KCNH2, KDR, MMP2, MMP9, PIK3CA, PTGS2, RORC, SLC6A4, SMAD3, SRC, TERT 7.53278
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA2A, BCL2, CDC25B, DRD2, DRD3, DRD4, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 7.31182
[BP] GO:0007193 None ADORA1, ADRA2A, DRD2, DRD3, DRD4, GRM1, GRM3, GRM5, GRM8 7.31182
[BP] GO:0048878 chemical homeostasis ADRA2A, AKR1B1, BCL2, CA12, CA2, CA7, DRD2, DRD3, DRD4, EGFR, ESR1, FABP3, FABP4, GPR35, GRIK5, GRM1, GRM5, INSR, KCNH2, MET, PIK3CA, PIK3CB, SMAD3 7.24488
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA2A, BCL2, CDC25B, DRD2, DRD3, DRD4, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 7.24488
[BP] GO:0032844 regulation of homeostatic process ADORA1, ADRA2A, AURKB, BCL2, CA2, CA7, CDK6, DRD2, DRD3, EGFR, HCAR2, KDR, PIK3CB, PTGS2, SRC, TNKS, TNKS2 7.23103
[BP] GO:0006631 fatty acid metabolic process ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, FABP3, PPARA, PTGS1, PTGS2 7.12958
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, DRD3, DRD4, FABP3, PPARA, SLC1A1 7.11369
[BP] GO:0008284 positive regulation of cell proliferation ADRA2A, AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, DRD2, DRD3, EGFR, ESR1, F3, FLT3, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, PIM1, PTGS2, TEK, TERT 7.0229
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, PTGS1, PTGS2 7.0229
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ADRA2A, BCL2, CDK6, CYP19A1, CYP1B1, DRD2, DRD3, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 6.983
[BP] GO:0042493 response to drug AKR1B1, AXL, BCL2, CA9, CDK6, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, EGFR, FABP3, HSD11B2, KCNH2, KDR, PTGS2, SLC6A2, SLC6A3, SLC6A4, SRC 6.85557
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, DRD2, EGFR, GRM1, GRM3, GRM5, GRM8, PTGS2 6.83517
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, PTGS2, SLC6A4, SMAD3, SRC, TEK, TERT 6.83517
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ADRA2A, BCL2, CDK6, CYP19A1, CYP1B1, DRD2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 6.83473
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19 6.73082
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GRIK5, HCAR2, HSPA1A, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 6.71235
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, PTGS2, SLC6A4, SMAD3, SRC, TEK, TERT 6.69593
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GRIK5, HCAR2, HSPA1A, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 6.66889
[BP] GO:0010035 response to inorganic substance AKR1B1, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, EGFR, FABP4, KDR, MMP9, PTGS2, SLC6A3, SRC, TERT 6.5696
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ADRA2A, BCL2, CYP19A1, CYP1B1, DRD2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 6.5478
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, PTGS1, PTGS2 6.37781
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRA2A, AURKB, BCL2, CDC25B, CSNK2A1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, GRM1, GRM3, GRM5, HSPA1A, IGF1R, INSR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, XDH 6.33599
[BP] GO:0007215 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 6.31519
[BP] GO:0043271 negative regulation of ion transport ADORA1, ADRA2A, BCL2, DRD2, DRD3, DRD4, GPR35, KCNH2, MMP9, PTGS2 6.30282
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, PTGS2, SLC6A4, SMAD3, SRC, TEK, TERT 6.30258
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ADRA2A, BCL2, CDK6, CYP19A1, CYP1B1, DRD2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 6.27451
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, HSD11B1, HSD11B2, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH 6.26663
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GRIK5, HCAR2, HSPA1A, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 6.20383
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA2A, BCL2, CDC25B, DRD2, DRD4, EGFR, ESRRB, FABP3, FLT3, GRM1, GRM5, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 6.13594
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA2A, BCL2, CDC25B, DRD2, DRD4, EGFR, ESRRB, FABP3, FLT3, GRM1, GRM5, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 6.13594
[BP] GO:0071310 cellular response to organic substance ADRA2A, AKR1B1, ALPL, AXL, BCL2, CDK6, CYP1A1, CYP1B1, EGFR, ESR1, FABP4, FLT3, GRIK5, GRM5, IGF1R, INSR, KDR, MMP2, PIK3CA, PTGS2, RORC, SLC6A4, SMAD3, SRC 6.0328
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F10, F3, INSR, MET, PIK3CA, PIK3CB, SRC, TEK 6.03048
[BP] GO:0048583 regulation of response to stimulus ADORA1, ADRA2A, AKR1B1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, ESRRA, F10, F3, FABP4, FLT3, GPR35, GRM1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SLC6A3, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 6.03048
[BP] GO:0030335 positive regulation of cell migration ADRA2A, BCL2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 5.99517
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA2A, AURKB, BCL2, CDC25B, CSNK2A1, DRD2, DRD3, DRD4, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 5.96604
[BP] GO:0010243 response to organonitrogen compound AKR1B1, DRD2, DRD3, DRD4, EGFR, FABP3, FLT3, GRM5, HSD11B2, IGF1R, INSR, MMP2, PPARA, PTGS2, SLC6A3, SLC6A4, SRC, TEK, TYR 5.94705
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA2A, AURKB, BCL2, CDC25B, CSNK2A1, DRD2, DRD3, DRD4, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 5.93849
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, ADRA2A, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, F3, FABP4, FLT3, GPR35, GRM1, GRM3, GRM5, HSPA1A, IGF1R, INSR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, XDH 5.93064
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRA2A, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, F10, F3, FLT3, GPR35, GRM1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 5.88901
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, AXL, BCL2, CA1, CSNK2A1, DRD2, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2 5.8766
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 5.8766
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP2D6, DRD2, DRD3, DRD4, EGFR, HSPA1A, SLC6A3 5.8766
[BP] GO:2000147 positive regulation of cell motility ADRA2A, BCL2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 5.84775
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 5.81757
[BP] GO:0044092 negative regulation of molecular function ADORA3, ADRA2A, AURKB, CSNK2A1, CYP1B1, CYP2D6, DRD2, DRD3, DRD4, DUSP3, ESR1, FABP4, GPR35, GRM3, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC, TNKS 5.75208
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, DRD3, DRD4, FABP3, PPARA, SLC1A1 5.71141
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRA2A, AXL, BCL2, CA2, CDK6, CYP1B1, DRD2, DRD3, EGFR, ESR1, ESRRA, ESRRB, F3, GPR35, GRM1, HCAR2, HSPA1A, INSR, KCNH2, KDR, MET, MMP12, MMP9, PIK3CA, PIM1, PTGS2, SLC1A1, SLC6A3, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS2, XDH 5.71141
[BP] GO:0051272 positive regulation of cellular component movement ADRA2A, BCL2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 5.70351
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA2A, AURKB, BCL2, CDC25B, CSNK2A1, DRD2, DRD3, DRD4, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 5.69442
[BP] GO:0032225 None DRD2, DRD3, DRD4, PTGS2, SLC6A4 5.69442
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CES1, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, KDR, SLC6A3, SLC6A4, SRC 5.6909
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, INSR, KDR, PIK3CA, PPARA, SMAD3, SRC, TEK, TYR 5.63936
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA2A, BCL2, CDC25B, DRD2, DRD4, EGFR, ESRRB, FLT3, GRM1, GRM5, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 5.63377
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ADRA2A, AXL, BCL2, CA2, CA7, CYP19A1, DRD2, DRD3, DRD4, EGFR, GPR35, GRIK5, GRM5, HCAR2, HSPA1A, INSR, KCNH2, MMP12, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TERT 5.63046
[BP] GO:0032787 None ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, FABP3, GBA2, PPARA, PTGS1, PTGS2 5.63046
[BP] GO:0051716 cellular response to stimulus ADRA2A, AKR1B1, ALPL, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, GRIK5, GRM1, GRM5, HSPA1A, IGF1R, INSR, KCNH2, KDR, MMP2, MMP9, NUAK1, PIK3CA, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TERT 5.57497
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA2A, AURKB, BCL2, CDC25B, DRD2, DRD3, DRD4, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 5.57497
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD2, DRD3, EGFR, HCAR2, PIK3CB, PTGS2, TNKS, TNKS2 5.57159
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DRD2, DRD3, DRD4, EGFR, ESR1, PPARA, RORC, SLC6A4, SRC 5.55917
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, BCL2, CA2, CYP1A1, DRD2, DRD3, EGFR, GRM1, HSD11B2, HSPA1A, MMP2, PPARA, PTGS2, SLC6A4, SMAD3, SRC, TEK, TERT, TYR 5.55492
[BP] GO:0040017 positive regulation of locomotion ADRA2A, BCL2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK, TERT 5.54617
[BP] GO:1901698 response to nitrogen compound AKR1B1, DRD2, DRD3, DRD4, EGFR, FABP3, FLT3, GRM5, HSD11B2, IGF1R, INSR, MMP2, PPARA, PTGS2, SLC6A3, SLC6A4, SRC, TEK, TYR 5.52026
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.50476
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.50476
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPR35, GRM3, GRM8, HSPA1A, IGF1R, KCNH2, KDR, MET, MMP12, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 5.48867
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.36469
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, ADRA2A, AKR1B1, CYP19A1, CYP1A1, CYP1B1, DRD2, EGFR, ESR1, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.3323
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA2A, BCL2, CDC25B, DRD2, DRD4, EGFR, FLT3, GRM1, GRM5, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 5.28978
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT 5.27128
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRA2A, AKR1B1, AXL, BCL2, CA1, CA2, CDK6, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KCNH2, KDR, MET, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2 5.21513
[BP] GO:0051347 positive regulation of transferase activity ADORA1, ADRA2A, AURKB, CDC25B, DRD2, DRD4, EGFR, FLT3, GRM1, GRM5, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK, TNKS 5.20746
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA2A, BCL2, CDK6, CYP19A1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, SLC6A3, SMAD3, SRC, TEK, TERT, XDH 5.1924
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, ADRA2A, AXL, BCL2, CA2, CYP19A1, DRD2, DRD3, DRD4, EGFR, HCAR2, INSR, KCNH2, MMP12, PTGS2, SLC6A4, SMAD3, SRC, TERT 5.18042
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 5.15669
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA2A, BCL2, CDC25B, DRD2, DRD4, DUSP3, EGFR, ESRRB, FABP4, FLT3, GRM1, GRM5, IGF1R, INSR, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, TEK, XDH 5.1014
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA2A, BCL2, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TERT, XDH 5.1014
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA2A, BCL2, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TERT, XDH 5.0824
[BP] GO:0044093 positive regulation of molecular function ADORA1, ADRA2A, AURKB, BCL2, CDC25B, DRD2, DRD4, EGFR, ESR1, ESR2, F3, FLT3, GRM1, GRM5, HSPA1A, INSR, MET, MMP9, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, XDH 5.07141
[BP] GO:1900543 None ADRA2A, DRD2, DRD3, DRD4, GRM3, GRM8, PPARA 5.07141
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GPR35, GRM3, GRM8, HCAR2, HSPA1A, IGF1R, KCNH2, KDR, MET, MMP12, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A3, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 5.05221
[BP] GO:0045980 None ADRA2A, DRD2, DRD3, DRD4, GRM3, GRM8, PPARA 5.03421
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 5.0214
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, DRD3, DRD4, FABP3, GRIA2, GRIA4, GRIK5, KCNH2, PPARA, SLC1A1, SLC6A2, SLC6A3, SLC6A4 5.01008
[BP] GO:0030818 None ADRA2A, DRD2, DRD3, DRD4, GRM3, GRM8 4.98488
[BP] GO:0033674 positive regulation of kinase activity ADORA1, ADRA2A, CDC25B, DRD2, DRD4, EGFR, FLT3, GRM1, GRM5, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK 4.97183
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, ADRA2A, AURKB, BCL2, CDC25B, DRD2, DRD4, EGFR, ESR1, F3, FLT3, GRM1, GRM5, HSPA1A, INSR, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK, TERT, TNKS, XDH 4.96791
[BP] GO:0007188 None ADORA1, ADRA2A, DRD2, DRD3, DRD4, GRM1, GRM3, GRM5, GRM8 4.96791
[BP] GO:0030803 None ADRA2A, DRD2, DRD3, DRD4, GRM3, GRM8 4.87598
[BP] GO:0051338 regulation of transferase activity ADORA1, ADRA2A, AURKB, CDC25B, DRD2, DRD4, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, IGF1R, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK, TNKS 4.8577
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2C19 4.82465
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A3, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TYR, XDH 4.82465
[BP] GO:0018958 None AKR1B1, BCL2, DRD2, DRD3, DRD4, SLC6A3, TYR 4.82465
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, ADRA2A, DRD4, DUSP3, EGFR, FLT3, GRM1, IGF1R, INSR, PIK3CB, PTPN1, SRC 4.81942
[BP] GO:0030815 None ADRA2A, DRD2, DRD3, DRD4, GRM3, GRM8 4.78234
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, BCL2, CES1, CYP19A1, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, GBA2, SLC6A3, TYR 4.78125
[BP] GO:0080134 regulation of response to stress ADORA1, ADRA2A, CDK6, CYP19A1, DRD2, DUSP3, EGFR, ESR1, F3, FABP4, HSPA1A, IGF1R, MET, MMP12, MMP2, NUAK1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TERT, XDH 4.76691
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, AURKB, AXL, BCL2, CA2, CA9, CDC25B, CDK6, CES1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD17B2, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, RORC, SLC6A3, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS2, TYR 4.76214
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIM1, SRC, TEK, TNKS 4.74666
[BP] GO:1900372 None ADRA2A, DRD2, DRD3, DRD4, GRM3, GRM8 4.74666
[BP] GO:0030809 None ADRA2A, DRD2, DRD3, DRD4, GRM3, GRM8 4.74666
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AXL, CDK6, CYP1B1, EGFR, ESR1, GRIK5, GRM5, IGF1R, INSR, MMP2, MMP9, PIK3CA, PTGS2, RORC, SLC6A4, SRC 4.70485
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC, TEK 4.70415
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP2D6, FABP3, FABP4, FUT7, GBA2, HSPA1A, MMP1, MMP12, MMP2, MMP9, PIK3CB, SLC6A3, SRC, XDH 4.70415
[BP] GO:0030800 None ADRA2A, DRD2, DRD3, DRD4, GRM3, GRM8 4.70222
[BP] GO:0043549 regulation of kinase activity ADORA1, ADRA2A, CDC25B, DRD2, DRD4, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, IGF1R, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK 4.69588
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD2, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TEK, TNKS, XDH 4.69588
[BP] GO:1904063 None ADRA2A, DRD2, DRD3, DRD4, GPR35, KCNH2, MMP9 4.68239
[BP] GO:0050801 ion homeostasis BCL2, CA12, CA2, CA7, DRD2, DRD3, DRD4, EGFR, ESR1, FABP3, GPR35, GRM1, GRM5, KCNH2, PIK3CB, SMAD3 4.68239
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADRA2A, BCL2, CDC25B, DRD2, DRD4, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, IGF1R, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 4.63726
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA2A, DRD2, DRD4, EGFR, FLT3, GRM1, INSR, KDR, PIK3CB, PTPN1, SRC, TEK, XDH 4.59785
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ADRA2A, BCL2, CDC25B, CSNK2A1, DRD2, DRD4, EGFR, ESR1, F3, FLT3, GRM1, GRM5, HSPA1A, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.59218
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, ADRA2A, CDC25B, DRD2, DRD4, EGFR, FLT3, GRM1, GRM5, INSR, PIK3CA, PIK3CB, PTPN1, SRC 4.57368
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, ADRA2A, CYP1A1, DRD3, FABP3, FLT3, HCAR2, PPARA, PTGS2, RORC, SRC, TEK 4.57163
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A3, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TYR, XDH 4.49912
[BP] GO:0007187 None ADORA1, ADRA2A, DRD2, DRD3, DRD4, GRM1, GRM3, GRM5, GRM8 4.46622
[BP] GO:0045859 regulation of protein kinase activity ADORA1, ADRA2A, CDC25B, DRD2, DRD4, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, IGF1R, INSR, PIK3CA, PIK3CB, PTPN1, SRC 4.46622
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ADRA2A, BCL2, CDC25B, DRD2, DRD4, EGFR, ESR1, F3, FLT3, GRM1, GRM5, HSPA1A, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.46406
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA2A, AXL, BCL2, CA2, CYP1B1, DRD2, DRD3, EGFR, ESRRB, F3, HCAR2, HSPA1A, KDR, MET, MMP12, MMP9, PIM1, PTGS2, SLC1A1, SLC6A3, SMAD3, SRC, TEK, TERT 4.45194
[BP] GO:0009892 negative regulation of metabolic process ADORA1, ADRA2A, AURKB, BCL2, CSNK2A1, CYP2D6, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, HCAR2, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, XDH 4.4219
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 4.42028
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 4.36776
[BP] GO:0034766 None ADRA2A, DRD2, DRD3, DRD4, GPR35, KCNH2, MMP9 4.3612
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, DRD2, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TEK, TNKS, XDH 4.34324
[BP] GO:0032147 activation of protein kinase activity ADORA1, ADRA2A, DRD2, DRD4, EGFR, GRM1, INSR, PIK3CA, PIK3CB, PTPN1, SRC 4.34324
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.33045
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ADRA2A, DRD2, DRD4, DUSP3, EGFR, FLT3, GRM1, IGF1R, INSR, KDR, PIK3CB, PTPN1, SRC, TEK, XDH 4.33045
[BP] GO:0007194 None ADRA2A, DRD2, DRD3, DRD4, GRM3 4.31445
[BP] GO:0010038 response to metal ion BCL2, CA2, CYP1A1, CYP1A2, DRD2, EGFR, FABP4, MMP9, PTGS2, SLC6A3, TERT 4.28523
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.27036
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.25598
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CES1, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2 4.24922
[BP] GO:0098771 inorganic ion homeostasis BCL2, CA12, CA2, CA7, DRD2, DRD3, DRD4, EGFR, ESR1, GPR35, GRM1, GRM5, KCNH2, PIK3CB, SMAD3 4.222
[BP] GO:0034763 None ADRA2A, DRD2, DRD3, DRD4, GPR35, KCNH2, MMP9 4.201
[BP] GO:0031280 None ADRA2A, DRD2, DRD3, DRD4, GRM3 4.19091
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, ADRA2A, DRD4, EGFR, FLT3, GRM1, INSR, PIK3CB, PTPN1, SRC 4.13679
[BP] GO:0008217 None ADORA1, DRD2, DRD3, HSD11B2, PPARA, PTGS1, PTGS2, SMAD3 4.13582
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, CDK6, KDR, PIK3CB, SMAD3, SRC, TEK 4.12117
[BP] GO:0016310 phosphorylation AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TNKS 4.11808
[BP] GO:0051926 negative regulation of calcium ion transport ADRA2A, BCL2, DRD2, DRD4, GPR35, PTGS2 4.10747
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD2, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TYR, XDH 4.08142
[BP] GO:0051350 None ADRA2A, DRD2, DRD3, DRD4, GRM3 4.07551
[BP] GO:0040014 regulation of multicellular organism growth BCL2, DRD2, DRD3, PIK3CA, SLC6A3, TNKS2 4.03616
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, EGFR 4.02362
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, FABP3, GBA2, PIM1, PPARA, PTGS1, PTGS2, TYR 4.02328
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 3.99987
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK 3.98765
[BP] GO:0031399 regulation of protein modification process ADORA1, ADRA2A, BCL2, CDC25B, DRD2, DRD4, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 3.9649
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, AXL, BCL2, CA2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD2, DUSP3, EGFR, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, INSR, KDR, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RORC, SLC6A3, SMAD3, SRC, TEK, TYR 3.95839
[BP] GO:0001504 None SLC1A1, SLC6A2, SLC6A3, SLC6A4 3.93987
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, DRD2, DRD3, EGFR, ESR1, F3, FABP4, KDR, MET, MMP12, PPARA, PTGS2, SLC6A3, SMAD3, TEK 3.8771
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DRD2, DRD3, DUSP3, ESR1, HSPA1A, IGF1R, MET, MMP9, PTGS2, PTPN1, SRC, XDH 3.83774
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ADRA2A, BCL2, CDC25B, DRD2, DRD4, EGFR, FLT3, GRM1, GRM5, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 3.8301
[BP] GO:0044057 None ADORA1, ADORA3, ADRA2A, DRD2, DRD3, EGFR, GPR35, GRM1, HCAR2, KCNH2, PTGS2, SLC1A1, SMAD3 3.82442
[BP] GO:0043269 regulation of ion transport ADORA1, ADRA2A, BCL2, CA2, CA7, DRD2, DRD3, DRD4, GPR35, GRM5, KCNH2, MMP9, PTGS2, SLC6A4 3.8015
[BP] GO:0032413 None ADRA2A, DRD2, DRD3, DRD4, GPR35, MMP9 3.77171
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, PTGS2, TERT 3.73944
[BP] GO:0006584 None AKR1B1, DRD2, DRD3, DRD4, SLC6A3 3.71735
[BP] GO:0009712 None AKR1B1, DRD2, DRD3, DRD4, SLC6A3 3.71735
[BP] GO:0060078 None ADORA1, DRD4, GRIA2, GRIA4, GRIK5, GRM5 3.71353
[BP] GO:0045787 positive regulation of cell cycle AURKB, CDC25B, CYP1A1, DRD2, DRD3, DUSP3, EGFR, INSR, SLC6A4, SRC, TERT 3.71353
[BP] GO:0051934 None SLC6A2, SLC6A3, SLC6A4 3.71353
[BP] GO:0090494 None SLC6A2, SLC6A3, SLC6A4 3.71353
[BP] GO:0090493 None SLC6A2, SLC6A3, SLC6A4 3.71353
[BP] GO:0051583 None SLC6A2, SLC6A3, SLC6A4 3.71353
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP2C19, CYP2D6 3.71353
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, CA2, CA7, DRD2, DRD4, EGFR, PTGS2 3.70874
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, F10, F3, FLT3, FUT7, GBA2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SLC6A3, SMAD3, SRC, TEK, TNKS, TNKS2, TYR, XDH 3.6935
[BP] GO:1900542 None ADRA2A, DRD2, DRD3, DRD4, ESRRB, GRM3, GRM8, INSR, PPARA 3.69178
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, RORC, SRC 3.67641
[BP] GO:0055080 cation homeostasis BCL2, CA2, CA7, DRD2, DRD3, DRD4, EGFR, ESR1, GPR35, GRM1, GRM5, KCNH2, PIK3CB, SMAD3 3.6696
[BP] GO:0045761 None ADRA2A, DRD2, DRD3, DRD4, GRM3 3.64185
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2D6, EGFR 3.62565
[BP] GO:0009611 response to wounding ACHE, ADORA3, BCL2, CYP1A1, DRD2, EGFR, PPARA, SMAD3 3.61134
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CES1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.60574
[BP] GO:0006140 None ADRA2A, DRD2, DRD3, DRD4, ESRRB, GRM3, GRM8, INSR, PPARA 3.59972
[BP] GO:0031324 negative regulation of cellular metabolic process ADRA2A, AURKB, BCL2, CSNK2A1, CYP2D6, DRD2, DRD3, DRD4, DUSP3, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, HSPA1A, IGF1R, MET, MMP12, MMP9, PIK3CA, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, XDH 3.58877
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD2, DRD3, DRD4, SLC6A3 3.56402
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.55747
[BP] GO:0032410 None ADRA2A, DRD2, DRD3, DRD4, GPR35, MMP9 3.55673
[BP] GO:0003008 None ADORA1, ADRA2A, AKR1B1, BCL2, CYP1B1, DRD2, DRD3, EGFR, GRM1, GRM5, GRM8, HSD11B2, INSR, KCNH2, PIK3CA, PTGS2, SLC6A3, SLC6A4, SRC, TEK, TYR 3.55264
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 3.52635
[BP] GO:0043436 oxoacid metabolic process ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, FABP3, GBA2, PIM1, PPARA, PTGS1, PTGS2, TYR 3.50859
[BP] GO:0051726 regulation of cell cycle AURKB, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, DRD2, DRD3, DUSP3, EGFR, HSPA1A, INSR, PIM1, PTGS2, SLC6A4, SMAD3, SRC, TERT, TNKS 3.50518
[BP] GO:0098810 None SLC6A2, SLC6A3, SLC6A4 3.50518
[BP] GO:0040008 regulation of growth BCL2, CSNK2A1, DRD2, DRD3, EGFR, ESR2, HSPA1A, INSR, PIK3CA, PIM1, SLC6A3, SLC6A4, SMAD3, TNKS2 3.50049
[BP] GO:0055082 cellular chemical homeostasis BCL2, CA2, CA7, DRD2, DRD3, DRD4, ESR1, GPR35, GRIK5, GRM1, GRM5, PIK3CA, PIK3CB, SMAD3 3.50049
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRA2A, AURKB, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A3, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 3.48799
[BP] GO:0007346 regulation of mitotic cell cycle AURKB, BCL2, CDC25B, CDK6, CYP1A1, DRD3, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, TERT, TNKS 3.45795
[BP] GO:0042391 None ADORA1, BCL2, DRD4, GPR35, GRIA2, GRIA4, GRIK5, GRM5, KCNH2, KDR, SRC 3.44744
[BP] GO:0009968 negative regulation of signal transduction ADRA2A, BCL2, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SMAD3, SRC, TERT, XDH 3.42129
[BP] GO:0006082 organic acid metabolic process ALOX5, CES1, CES2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, FABP3, GBA2, PIM1, PPARA, PTGS1, PTGS2, TYR 3.42129
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.38055
[BP] GO:0009895 negative regulation of catabolic process ADORA1, ADRA2A, BCL2, EGFR, HCAR2, MET, PIK3CA, PPARA, SMAD3 3.32195
[BP] GO:0051940 None DRD2, DRD3, DRD4 3.32194
[BP] GO:0051584 None DRD2, DRD3, DRD4 3.32194
[BP] GO:0072507 divalent inorganic cation homeostasis BCL2, DRD2, DRD3, DRD4, EGFR, ESR1, GPR35, GRM1, GRM5, PIK3CB, SMAD3 3.27959
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, ADRA2A, DRD4, DUSP3, EGFR, FLT3, GRM1, IGF1R, INSR, PIK3CB, PTPN1, SRC 3.27587
[BP] GO:0032845 None ADORA1, ADRA2A, BCL2, DRD2, SRC, TNKS, TNKS2 3.26263
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, DRD2, EGFR, ESR1, FABP4, HSPA1A, MMP12, MMP2, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK 3.25643
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MMP9, PTGS2, PTPN1, SRC 3.25102
[BP] GO:0006979 response to oxidative stress AKR1B1, AXL, BCL2, CYP1B1, EGFR, HSPA1A, MMP9, PTGS1, PTGS2, SRC 3.24608
[BP] GO:0051098 regulation of binding AURKB, BCL2, CYP2D6, MET, MMP9, PPARA, SMAD3, SRC, TERT, TNKS 3.24608
[BP] GO:1901652 response to peptide AKR1B1, FABP3, GRM5, HSD11B2, IGF1R, INSR, PPARA, PTGS2, SRC, TEK 3.18461
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, DRD2, DRD3, KDR, SRC 3.18459
[BP] GO:0030817 None ADRA2A, DRD2, DRD3, DRD4, GRM3, GRM8 3.1843
[BP] GO:0042752 None ADORA1, DRD2, DRD3, DRD4, PPARA, RORC 3.1843
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, ADRA2A, DRD4, EGFR, FLT3, GRM1, INSR, PIK3CB, PTPN1, SRC 3.17143
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, PTGS2, RORC, SLC6A4, SRC 3.17143
[BP] GO:0042417 None DRD2, DRD3, DRD4, SLC6A3 3.13355
[BP] GO:0009894 regulation of catabolic process ADORA1, ADRA2A, BCL2, CSNK2A1, EGFR, ESRRB, HCAR2, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PPARA, PTPN1, SMAD3 3.12738
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TERT, TNKS, TNKS2 3.1229
[BP] GO:0010638 positive regulation of organelle organization AURKB, BCL2, DRD3, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2 3.1229
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CDK6, CYP1B1, EGFR, KCNH2, KDR, PTGS2, SRC 3.11397
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, EGFR, FLT3, HSD11B2, PTGS2, SRC 3.08265
[BP] GO:0003018 None ADORA1, ADRA2A, EGFR, PTGS2, SLC6A4, SRC, TEK 3.08265
[BP] GO:0031279 None ADRA2A, DRD2, DRD3, DRD4, GRM3 3.05895
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, EGFR, FLT3, HSD11B2, PTGS2, SRC 3.04375
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.03561
[BP] GO:0007195 None DRD2, DRD3, DRD4 3.03561
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5 3.03561
[BP] GO:0051339 None ADRA2A, DRD2, DRD3, DRD4, GRM3 3.03208
[BP] GO:0007610 None BCL2, DRD2, DRD3, DRD4, EGFR, GRM1, GRM5, INSR, PPARA, PTGS2, SLC6A3, SLC6A4 3.01073
[BP] GO:0007268 None DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 3.01073
[BP] GO:0098916 None DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 3.01073
[BP] GO:0050793 regulation of developmental process AXL, BCL2, CA2, CDK6, CYP1B1, DRD2, DRD3, EGFR, ESR1, ESRRA, ESRRB, F3, INSR, KDR, NUAK1, PIK3CA, PIM1, PPARA, PTGS2, RORC, SLC6A3, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS2, XDH 2.98191
[BP] GO:0045744 None ADRA2A, DRD2, DRD3, MET 2.98191
[BP] GO:0010039 response to iron ion BCL2, CYP1A1, DRD2, SLC6A3 2.98191
[BP] GO:0055065 metal ion homeostasis BCL2, DRD2, DRD3, DRD4, EGFR, ESR1, GPR35, GRM1, GRM5, KCNH2, PIK3CB, SMAD3 2.98191
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 2.98191
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, DRD2, PTGS2, SLC6A4 2.97971
[BP] GO:0051130 positive regulation of cellular component organization AURKB, AXL, BCL2, DRD2, DRD3, ESR1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2 2.9712
[BP] GO:0099536 None DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 2.9458
[BP] GO:0099537 None DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2 2.9458
[BP] GO:0022898 None ADRA2A, BCL2, DRD2, DRD3, DRD4, GPR35, GRM5, MMP9 2.94578
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, DRD2 2.93733
[BP] GO:0034776 None DRD2, DRD3, DRD4 2.92575
[BP] GO:0006874 cellular calcium ion homeostasis BCL2, DRD2, DRD3, DRD4, ESR1, GPR35, GRM1, GRM5, PIK3CB, SMAD3 2.91075
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 2.90994
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, DRD2, DRD3, EGFR, HCAR2, MMP12, SLC6A4, SRC 2.90347
[BP] GO:0015908 None DRD2, DRD3, DRD4, FABP3, PPARA 2.89586
[BP] GO:0045934 None ADRA2A, AURKB, DRD2, DRD3, DRD4, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, HSPA1A, MMP12, PPARA, RORC, SMAD3, SRC, TERT, TNKS, TNKS2 2.89196
[BP] GO:0010907 None ESRRB, INSR, PPARA, SRC 2.8915
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CYP1A1, EGFR, ESR1, FLT3, MET, PIK3CB, PIM1, SRC, TEK, TYR 2.88927
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, EGFR, INSR, PTGS2, SMAD3, XDH 2.88392
[BP] GO:0051172 None ADRA2A, AURKB, CSNK2A1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, HSPA1A, IGF1R, MMP12, MMP9, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2, XDH 2.8722
[BP] GO:0042737 drug catabolic process ACHE, CYP1A2, CYP2A6, CYP2C19, CYP2D6, SLC6A3 2.87161
[BP] GO:0001503 ossification ALPL, BCL2, EGFR, MMP2, MMP9, TEK 2.87161
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, DRD2, MMP12, PPARA, SMAD3, TEK 2.85583
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ADRA2A, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A3, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 2.84835
[BP] GO:0030003 cellular cation homeostasis BCL2, CA2, CA7, DRD2, DRD3, DRD4, ESR1, GPR35, GRM1, GRM5, PIK3CB, SMAD3 2.84089
[BP] GO:0009115 None AOX1, XDH 2.84089
[BP] GO:0030814 None ADRA2A, DRD2, DRD3, DRD4, GRM3, GRM8 2.84017
[BP] GO:0048638 regulation of developmental growth BCL2, DRD2, DRD3, INSR, PIK3CA, PIM1, SLC6A3, SLC6A4, TNKS2 2.84017
[BP] GO:0007154 None ADORA1, AXL, BCL2, DRD2, DRD3, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, PTGS2, SLC1A1, SLC6A2, TEK 2.83972
[BP] GO:0015872 None SLC6A2, SLC6A3, SLC6A4 2.83234
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2A6, CYP2C19 2.83234
[BP] GO:0055074 calcium ion homeostasis BCL2, DRD2, DRD3, DRD4, ESR1, GPR35, GRM1, GRM5, PIK3CB, SMAD3 2.82558
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, EGFR, MMP9, SRC 2.8249
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD2, DRD4, EGFR, HSD11B2, HSPA1A, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, SLC6A2, SLC6A4, SMAD3, SRC, TEK, TERT 2.81287
[BP] GO:0048732 gland development BCL2, CSNK2A1, CYP19A1, EGFR, INSR, PIK3CA, SMAD3, TYR 2.79842
[BP] GO:0032409 None ADRA2A, BCL2, DRD2, DRD3, DRD4, GPR35, GRM5, MMP9 2.79842
[BP] GO:0030802 None ADRA2A, DRD2, DRD3, DRD4, GRM3, GRM8 2.79049
[BP] GO:0072503 cellular divalent inorganic cation homeostasis BCL2, DRD2, DRD3, DRD4, ESR1, GPR35, GRM1, GRM5, PIK3CB, SMAD3 2.78689
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 2.7787
[BP] GO:0006873 cellular ion homeostasis BCL2, CA2, CA7, DRD2, DRD3, DRD4, ESR1, GPR35, GRM1, GRM5, PIK3CB, SMAD3 2.7626
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, PTGS2, SLC6A4, SRC 2.74143
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, ADRA2A, CYP19A1, DRD2, DRD3, DRD4, EGFR, GRIK5, HCAR2, MMP12, SLC6A4, SRC 2.73811
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.73811
[BP] GO:0060134 None DRD2, DRD3, SLC6A3 2.73811
[BP] GO:0071495 cellular response to endogenous stimulus ADRA2A, AKR1B1, EGFR, ESR1, FLT3, GRM5, IGF1R, INSR, MMP2, PTGS2, SLC6A4, SMAD3, SRC 2.73424
[BP] GO:0032467 None AURKB, CDC25B, DRD2, DRD3 2.73314
[BP] GO:0019725 cellular homeostasis BCL2, CA2, CA7, DRD2, DRD3, DRD4, ESR1, GPR35, GRIK5, GRM1, GRM5, PIK3CA, PIK3CB, SMAD3 2.72855
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, PTGS2, SRC, TEK 2.72395
[BP] GO:0051051 negative regulation of transport ADORA1, ADRA2A, BCL2, DRD2, DRD3, DRD4, GPR35, HSPA1A, KCNH2, MMP9, PTGS2 2.71267
[BP] GO:0032355 response to estradiol CYP1A2, EGFR, ESR1, ESRRA, PTGS2, SLC6A4 2.70743
[BP] GO:0045936 None ADRA2A, DRD2, DRD3, DRD4, DUSP3, FABP4, GRM3, GRM8, IGF1R, PPARA, PTPN1, XDH 2.69281
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC, TEK 2.69214
[BP] GO:0010563 None ADRA2A, DRD2, DRD3, DRD4, DUSP3, FABP4, GRM3, GRM8, IGF1R, PPARA, PTPN1, XDH 2.68895
[BP] GO:0051952 None ADORA1, ADRA2A, DRD2, DRD3, DRD4 2.68791
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ADRA2A, BCL2, CDC25B, CSNK2A1, DRD2, DRD4, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 2.68647
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ADRA2A, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A3, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 2.6665
[BP] GO:1901020 None ADRA2A, DRD2, DRD4, GPR35 2.65848
[BP] GO:0023052 None ADORA1, DRD2, DRD3, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, KCNH2, SLC1A1, SLC6A2, TEK 2.65767
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.65767
[BP] GO:0051580 None DRD2, DRD3, DRD4 2.65767
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, BCL2, CDC25B, CYP19A1, EGFR, ESR1, ESRRB, HSD17B2, INSR, PTGS2, SRC 2.65626
[BP] GO:0010810 regulation of cell-substrate adhesion BCL2, CDK6, KDR, PIK3CB, SMAD3, SRC, TEK 2.65077
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, PTGS2, TERT 2.64809
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, BCL2, CDK6, CYP1B1, DRD2, FABP3, HSPA1A, PTGS2, SLC6A4, SMAD3, TERT, XDH 2.63122
[BP] GO:1900371 None ADRA2A, DRD2, DRD3, DRD4, GRM3, GRM8 2.63122
[BP] GO:0030808 None ADRA2A, DRD2, DRD3, DRD4, GRM3, GRM8 2.61451
[BP] GO:0090087 None ACHE, ADORA1, ADRA2A, CA2, DRD2, DRD3, DRD4, EGFR, HCAR2, MMP12, PTGS2, PTPN1, SMAD3, SRC 2.60311
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, PTGS2, SMAD3 2.58503
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.58503
[BP] GO:0051937 None SLC6A2, SLC6A3, SLC6A4 2.5756
[BP] GO:0070198 None TERT, TNKS, TNKS2 2.5756
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 2.5756
[BP] GO:0035556 intracellular signal transduction ADRA2A, AKR1B1, AXL, BCL2, CYP1B1, DRD2, DRD3, EGFR, GRM5, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIK3CB, PTPN1, SRC, TEK 2.56641
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, PTGS2, TYR 2.55173
[BP] GO:0045776 None ADORA1, DRD2, DRD3, PPARA 2.54934
[BP] GO:0010564 regulation of cell cycle process AURKB, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, DRD2, DRD3, EGFR, HSPA1A, INSR, TERT, TNKS 2.54486
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CYP1A1, EGFR, HSD11B2, PTGS2, SLC6A4, SRC, TYR 2.53734
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, ADRA2A, CA2, DRD2, DRD3, DRD4, ESR1, GPR35, GRM1, GRM3, GRM5, GRM8, HCAR2, INSR, PIK3CA, PIK3CB, SRC 2.52744
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, ADRA2A, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A3, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 2.52474
[BP] GO:0007623 circadian rhythm DRD2, DRD3, EGFR, PPARA, RORC, SLC6A4 2.52166
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, GBA2 2.52166
[BP] GO:1903170 None ADRA2A, DRD2, DRD4, GPR35 2.51961
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.51961
[BP] GO:0061098 None ADORA1, ADRA2A, GRM5, PTPN1 2.51961
[BP] GO:0009891 positive regulation of biosynthetic process AURKB, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, INSR, KDR, MET, MMP12, PPARA, PTGS2, RORC, SMAD3, SRC, TERT, TNKS, TNKS2 2.50789
[BP] GO:0050890 None ADORA1, DRD2, DRD3, EGFR, GRM5, INSR, PTGS2, SLC6A4 2.50718
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.50718
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.50718
[BP] GO:0070920 None EGFR, ESR1, TERT 2.50718
[BP] GO:0007267 None ADORA1, DRD2, DRD3, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1, SLC6A2, TEK 2.5059
[BP] GO:0034762 None ADRA2A, BCL2, CA2, DRD2, DRD3, DRD4, GPR35, GRM5, KCNH2, MMP9 2.49602
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, EGFR, FLT3, HSD11B2, PTGS2 2.4833
[BP] GO:0010959 None ADORA1, ADRA2A, BCL2, DRD2, DRD3, DRD4, GPR35, KCNH2, PTGS2 2.47908
[BP] GO:0051046 None ACHE, ADORA1, ADRA2A, CYP19A1, DRD2, DRD3, DRD4, EGFR, GRIK5, HCAR2, MMP12, SLC6A4, SRC 2.47665
[BP] GO:0001954 positive regulation of cell-matrix adhesion CDK6, KDR, SMAD3, TEK 2.46373
[BP] GO:0099566 None GRM1, GRM5 2.46373
[BP] GO:0051944 None DRD2, DRD4 2.46373
[BP] GO:0046110 None AOX1, XDH 2.46373
[BP] GO:0060160 None DRD2, DRD3 2.46373
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.46373
[BP] GO:0032227 negative regulation of synaptic transmission, dopaminergic PTGS2, SLC6A4 2.46373
[BP] GO:0051586 None DRD2, DRD4 2.46373
[BP] GO:0003013 None ADORA1, ADRA2A, EGFR, PTGS2, SLC6A4, SRC, TEK 2.46363
[BP] GO:0043393 regulation of protein binding AURKB, BCL2, MET, MMP9, PPARA, SRC, TERT 2.46363
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, F3, MMP9, PTGS2, SMAD3, SRC, XDH 2.45191
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, CYP19A1, DRD2, DRD3, PPARA, SLC6A3, SMAD3, TEK 2.45191
[BP] GO:0030799 None ADRA2A, DRD2, DRD3, DRD4, GRM3, GRM8 2.45001
[BP] GO:1901386 None DRD2, DRD4, GPR35 2.45001
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.45001
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A3, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 2.43974
[BP] GO:0042136 neurotransmitter biosynthetic process ACHE, CYP1B1, SLC6A3, SLC6A4 2.43655
[BP] GO:0002009 morphogenesis of an epithelium BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.42693
[BP] GO:0045931 positive regulation of mitotic cell cycle CDC25B, CYP1A1, DRD3, DUSP3, INSR, TERT 2.42258
[BP] GO:0002791 None ACHE, ADORA1, ADRA2A, DRD2, DRD3, DRD4, EGFR, HCAR2, MMP12, SRC 2.41918
[BP] GO:0051588 None DRD2, DRD3, DRD4, GRIK5, SLC6A4 2.40821
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, INSR, PTGS2, SMAD3, XDH 2.40821
[BP] GO:1903522 None ADORA1, ADORA3, ADRA2A, DRD2, EGFR, KCNH2, PTGS2, SLC1A1 2.39981
[BP] GO:2001234 negative regulation of apoptotic signaling pathway BCL2, HSPA1A, MMP9, PTGS2, PTPN1, SRC, TERT 2.39981
[BP] GO:0008150 biological_process ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A3, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TYR, XDH 2.38417
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.3824
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process AURKB, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, IGF1R, INSR, MET, MMP12, PPARA, PTPN1, RORC, SMAD3, SRC, TERT, TNKS, TNKS2 2.3816
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, EGFR, IGF1R, INSR, SRC, TNKS, TNKS2 2.37781
[BP] GO:0071248 cellular response to metal ion CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 2.36677
[BP] GO:0045187 None ADORA1, DRD2, DRD3 2.31646
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.31646
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, EGFR, F10, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK, TNKS 2.3105
[BP] GO:0022414 reproductive process AKR1B1, ALPL, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, EGFR, ESR1, ESRRB, HSD11B2, HSD17B2, INSR, MMP2, MMP9, PTGS2, SLC6A4, SRC 2.29973
[BP] GO:0010906 None ESRRB, INSR, PPARA, RORC, SRC 2.29028
[BP] GO:0003014 None ADORA1, AKR1B1, BCL2, DRD2, HSD11B2 2.29028
[BP] GO:0045766 positive regulation of angiogenesis CYP1B1, F3, KDR, PTGS2, TEK, TERT 2.28203
[BP] GO:0030155 regulation of cell adhesion BCL2, CDK6, CYP1B1, DUSP3, KDR, NUAK1, PIK3CA, PIK3CB, PPARA, SMAD3, SRC, TEK 2.28203
[BP] GO:2001258 None DRD2, DRD4, GPR35, MMP9 2.28203
[BP] GO:0032412 None ADRA2A, DRD2, DRD3, DRD4, GPR35, GRM5, MMP9 2.27917
[BP] GO:0048148 None DRD2, DRD3, DRD4 2.25966
[BP] GO:0035813 None ADORA1, DRD2, DRD3 2.25966
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.25668
[BP] GO:0010676 None ESRRB, INSR, PPARA, SRC 2.25668
[BP] GO:0050994 None ADORA1, ADRA2A, HCAR2, PPARA 2.25668
[BP] GO:0050727 regulation of inflammatory response ADORA1, CYP19A1, EGFR, ESR1, FABP4, PPARA, PTGS2, SMAD3, TEK 2.23862
[BP] GO:2001242 regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MMP9, PTGS2, PTPN1, SRC 2.2317
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.2285
[BP] GO:0015909 None DRD2, DRD3, DRD4, FABP3 2.2285
[BP] GO:0033031 positive regulation of neutrophil apoptotic process HCAR2, PIK3CB 2.2162
[BP] GO:0070213 None TNKS, TNKS2 2.2162
[BP] GO:0006145 None AOX1, XDH 2.2162
[BP] GO:0051582 None DRD2, DRD4 2.2162
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.2162
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.21509
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.21509
[BP] GO:0015844 None SLC6A2, SLC6A3, SLC6A4 2.21509
[BP] GO:0042749 None ADORA1, DRD2, DRD3 2.21509
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.21509
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.21509
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.21509
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.21509
[BP] GO:0006875 cellular metal ion homeostasis BCL2, DRD2, DRD3, DRD4, ESR1, GPR35, GRM1, GRM5, PIK3CB, SMAD3 2.21509
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.21497
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.21497
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, EGFR, GRM5, IGF1R, INSR, MMP2, PTGS2, SLC6A4, SRC 2.20424
[BP] GO:0050730 None ADORA1, ADRA2A, EGFR, FLT3, GRM5, PTPN1, SRC 2.20424
[BP] GO:0051246 regulation of protein metabolic process ADORA1, ADRA2A, BCL2, CDC25B, CSNK2A1, DRD2, DRD4, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 2.20342
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR 2.20298
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 2.1972
[BP] GO:0032922 None DRD2, DRD3, PPARA, RORC 2.18947
[BP] GO:0051179 None ACHE, ADORA1, ADRA2A, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, DRD3, DRD4, EGFR, ESR1, F10, FABP3, GRIA2, GRIA4, GRIK5, HSPA1A, KCNH2, MMP12, MMP9, PPARA, SLC1A1, SLC6A2, SLC6A3, SLC6A4, SRC, TERT, TNKS, TNKS2, XDH 2.18874
[BP] GO:0051234 None ACHE, ADORA1, ADRA2A, ALOX5, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, DRD3, DRD4, EGFR, F10, FABP3, GRIA2, GRIA4, GRIK5, HSPA1A, KCNH2, MMP12, MMP9, PPARA, SLC1A1, SLC6A2, SLC6A3, SLC6A4, SRC, TERT, TNKS, XDH 2.18384
[BP] GO:0032880 regulation of protein localization ACHE, ADRA2A, BCL2, CSNK2A1, DRD2, DRD3, DRD4, EGFR, HCAR2, MMP12, PTGS2, PTPN1, SMAD3, SRC, TERT 2.18019
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, ADRA2A, AURKB, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A2, CYP1B1, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, XDH 2.17991
[BP] GO:0002682 regulation of immune system process ADORA1, AXL, BCL2, CA2, CDK6, CYP19A1, DRD2, DUSP3, ESR1, ESRRA, HCAR2, HSPA1A, MMP12, MMP2, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC 2.17645
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process AURKB, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, IGF1R, INSR, KDR, MET, MMP12, PPARA, RORC, SMAD3, SRC, TERT, TNKS, TNKS2 2.17489
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation MMP2, MMP9, TERT 2.17003
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.17003
[BP] GO:0050995 None ADORA1, ADRA2A, HCAR2 2.17003
[BP] GO:0007611 None DRD2, DRD3, EGFR, GRM5, INSR, PTGS2, SLC6A4 2.1695
[BP] GO:0046686 response to cadmium ion CYP1A2, EGFR, MMP9, TERT 2.16766
[BP] GO:2000116 regulation of cysteine-type endopeptidase activity CSNK2A1, F3, MMP9, PTGS2, SMAD3, SRC, XDH 2.15974
[BP] GO:0044248 cellular catabolic process ACHE, AKR1B10, AOX1, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP2D6, FABP3, FABP4, GBA2, HSPA1A, PIK3CB, SLC6A3, SRC, XDH 2.15347
[BP] GO:0046486 glycerolipid metabolic process ACHE, CSNK2A1, DRD2, EGFR, FABP3, FABP4, MET, PIK3CA, PIK3CB 2.14564
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.14161
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.14161
[BP] GO:0031667 response to nutrient levels ALPL, BCL2, CYP1A1, EGFR, HSD11B2, PTGS2, SLC6A4, SRC, TYR 2.13998
[BP] GO:0051953 None ADORA1, ADRA2A, DRD2 2.1218
[BP] GO:2000209 regulation of anoikis BCL2, PIK3CA, SRC 2.1218
[BP] GO:1903963 None DRD2, DRD3, DRD4 2.1218
[BP] GO:0044062 None ADORA1, DRD2, DRD3 2.1218
[BP] GO:0050482 None DRD2, DRD3, DRD4 2.1218
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.1218
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.10703
[BP] GO:0043065 positive regulation of apoptotic process BCL2, CYP1B1, F3, GRIK5, HCAR2, MMP9, PIK3CB, PTGS2, SMAD3, SRC, XDH 2.084
[BP] GO:0071241 cellular response to inorganic substance CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 2.0779
[BP] GO:0070201 None ACHE, ADRA2A, BCL2, DRD2, DRD3, DRD4, EGFR, HCAR2, MMP12, PTGS2, PTPN1, SMAD3, SRC 2.07409
[BP] GO:0030168 platelet activation ADRA2A, AXL, PIK3CA, PIK3CB, SRC 2.07364
[BP] GO:0051894 None KDR, SMAD3, TEK 2.07148
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.07148
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, ADRA2A, FLT3, GRM5, PTPN1, SRC 2.0681
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.0681
[BP] GO:0043068 positive regulation of programmed cell death BCL2, CYP1B1, F3, GRIK5, HCAR2, MMP9, PIK3CB, PTGS2, SMAD3, SRC, XDH 2.05416
[BP] GO:0031328 positive regulation of cellular biosynthetic process AURKB, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, INSR, MET, MMP12, PPARA, PTGS2, RORC, SMAD3, SRC, TERT, TNKS, TNKS2 2.04878
[BP] GO:1904018 positive regulation of vasculature development CYP1B1, F3, KDR, PTGS2, TEK, TERT 2.04747
[BP] GO:0050678 None CDK6, EGFR, F3, KDR, MMP12, SMAD3, TEK, XDH 2.04747
[BP] GO:0043696 None CDK6, ESRRB 2.04747
[BP] GO:0043697 None CDK6, ESRRB 2.04747
[BP] GO:0010641 None F3, SRC 2.04747
[BP] GO:0090325 None DRD2, DRD3 2.04747
[BP] GO:0007598 None F10, F3 2.04747
[BP] GO:0042321 None ADORA1, DRD2 2.04747
[BP] GO:0016477 cell migration AXL, CYP1B1, DRD2, EGFR, FUT7, KDR, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC, TEK 2.03255
[BP] GO:0050927 None F3, KDR, SMAD3 2.03022
[BP] GO:0050708 None ACHE, ADRA2A, DRD2, DRD3, DRD4, EGFR, HCAR2, MMP12, SRC 2.01672
[BP] GO:0007626 None DRD2, DRD3, DRD4, GRM1, GRM5, SLC6A3 2.00172
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, PPARA, SMAD3, TEK 2.00025
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ADRA2A, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, DRD2, DRD3, DRD4, EGFR, ESR1, F10, F3, FLT3, GBA2, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KCNH2, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTPN1, SLC1A1, SLC6A2, SLC6A3, SLC6A4, SMAD3, SRC, TEK, TERT 5.94705
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ADRA2A, ALOX5, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD2, DRD3, DRD4, EGFR, ESR1, F10, F3, FLT3, FUT7, GBA2, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSD11B2, HSD17B2, IGF1R, INSR, KCNH2, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SLC1A1, SLC6A2, SLC6A3, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TYR 5.88901
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRA2A, AXL, CA4, DRD2, DRD3, DRD4, F10, F3, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, SLC1A1, SLC6A2, SLC6A3, SLC6A4, TEK 5.84775
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ADRA2A, AXL, CA2, CA4, CA9, DRD2, DRD3, DRD4, DUSP3, EGFR, F10, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KCNH2, KDR, MET, PTGS2, SLC1A1, SLC6A2, SLC6A3, SLC6A4, SRC, TEK 5.44351
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ADRA2A, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, F10, F3, FLT3, FUT7, GBA2, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSD11B2, HSD17B2, IGF1R, INSR, KCNH2, KDR, MET, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, SLC1A1, SLC6A2, SLC6A3, SLC6A4, SRC, TEK, TYR 5.33856
[CC] GO:0098590 plasma membrane region ADORA1, ADRA2A, CA2, CA4, CA9, DRD2, EGFR, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, INSR, MET, PTGS2, SLC1A1, SRC, TEK 5.0824
[CC] GO:0044432 endoplasmic reticulum part BCL2, CES1, CES2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, EGFR, F10, FLT3, GBA2, GRIA2, HSD11B1, HSD11B2, HSD17B2, PTGS1, PTGS2, PTPN1 4.52312
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, ADRA2A, AXL, DRD2, DRD3, DRD4, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, SLC1A1, SLC6A2, SLC6A3, SLC6A4, TEK 4.50862
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, EGFR, GBA2, GRIA2, HSD11B1, HSD11B2, HSD17B2, PTGS1, PTGS2 3.67478
[CC] GO:0044456 None ACHE, ADORA1, DRD2, DRD4, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SLC6A3, SLC6A4, SRC 3.21989
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 3.03208
[CC] GO:0045121 membrane raft EGFR, INSR, KDR, PTGS2, SLC6A2, SLC6A3, SLC6A4, SRC, TEK 3.00024
[CC] GO:0098857 membrane microdomain EGFR, INSR, KDR, PTGS2, SLC6A2, SLC6A3, SLC6A4, SRC, TEK 2.98191
[CC] GO:0043235 receptor complex ADRA2A, EGFR, GRIA2, GRIA4, GRIK5, GRM1, IGF1R, INSR, SMAD3 2.74143
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AOX1, AURKB, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA7, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F10, FABP3, FABP4, FLT3, FUT7, GBA2, GRIA2, GRIA4, GRIK5, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, INSR, KCNH2, KDR, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SLC6A4, SMAD3, SRC, TERT, TNKS, TNKS2, TYR, XDH 2.71591
[CC] GO:0043005 None ADORA1, CA2, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PTGS2, SLC6A2, SLC6A3, SLC6A4, SRC 2.69323
[CC] GO:0016323 basolateral plasma membrane ADORA1, ADRA2A, CA2, CA4, CA9, EGFR, TEK 2.67291
[CC] GO:0042995 cell projection ADORA1, AKR1B1, CA2, CDK6, DRD2, DRD3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PIK3CA, PTGS2, SLC6A2, SLC6A3, SLC6A4, SRC, TEK 2.62882
[CC] GO:0014069 None ADORA1, DRD2, GRIK5, GRM1, GRM3, GRM5, SRC 2.52744
[CC] GO:0099572 None ADORA1, DRD2, GRIK5, GRM1, GRM3, GRM5, SRC 2.52744
[CC] GO:0005783 None ADORA1, BCL2, CA4, CES1, CES2, CYP19A1, CYP2D6, FLT3, GBA2, GRIK5, HSPA1A, KDR, PTGS2, PTPN1, XDH 2.51251
[CC] GO:0098589 membrane region EGFR, INSR, KDR, PTGS2, SLC6A2, SLC6A3, SLC6A4, SRC, TEK 2.48654
[CC] GO:0120025 None ADORA1, AKR1B1, CA2, CDK6, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PIK3CA, PTGS2, SLC6A2, SLC6A3, SLC6A4, SRC, TEK 2.46373
[CC] GO:0098794 None ADORA1, DRD2, DRD4, GRIA2, GRIA4, GRM3 2.30831
[CC] GO:0031233 None CA4, F10, F3 2.25966
[CC] GO:0044464 cell part ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA7, CA9, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A3, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TYR, XDH 2.20671
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, PTPN1, RORC, SMAD3, TNKS, TYR, XDH 16.0193
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 15.7404
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD2, DRD3, DRD4, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A3, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TYR, XDH 12.8902
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DUSP3, EGFR, F10, F3, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SRC, TEK, TERT, TNKS, TNKS2, TYR, XDH 11.6297
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 9.80011
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA2A, AXL, DRD2, DRD3, DRD4, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KCNH2, KDR, MET, PPARA, RORC, TEK 9.48747
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD2, DRD3, DRD4, ESR1, ESR2, ESRRA, ESRRB, F10, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A3, SLC6A4, SMAD3, TERT, TNKS, TNKS2, TYR, XDH 9.05808
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA2A, AXL, CDK6, DRD2, DRD3, DRD4, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KCNH2, KDR, MET, PPARA, RORC, TEK 8.63726
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 8.59557
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA2A, AXL, DRD2, DRD3, DRD4, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KCNH2, KDR, MET, PPARA, RORC, TEK 8.33931
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NQO2, PPARA, PTPN1, RORC, SMAD3, TNKS 8.33931
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA2A, AXL, DRD2, DRD3, DRD4, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KCNH2, KDR, MET, PPARA, RORC, SMAD3, TEK 8.01357
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2C19, CYP2D6, DRD2, DRD3, DRD4, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, SLC6A3, SLC6A4, SRC, TEK 7.95242
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6 7.77166
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, PTGS1, PTGS2, SRC 7.76007
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.68698
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, HSD11B1, HSD11B2, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH 7.65848
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, PTGS1, PTGS2, SRC 7.49364
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, F10, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A3, SLC6A4, SMAD3, TERT, TNKS, TNKS2, TYR, XDH 7.13608
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, PTGS1, PTGS2, TYR 7.0229
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, XDH 6.88722
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.68991
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, TYR 6.56279
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6 6.50764
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, HSD11B2, HSD17B1, NQO2, PTGS1, PTGS2, SRC, XDH 6.32257
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2C19, CYP2D6 6.26663
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 5.94705
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRA2A, AXL, DRD2, DRD3, DRD4, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, TEK 5.85842
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRA2A, AXL, DRD2, DRD3, DRD4, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, TEK 5.85842
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP2C19, CYP2D6 5.58332
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 5.38399
[MF] GO:1901338 None ADRA2A, DRD2, DRD3, DRD4, SLC6A3 5.2285
[MF] GO:0030594 None DRD2, DRD3, DRD4, GRIA2, GRIA4, GRIK5, GRM1, GRM5 5.02584
[MF] GO:0005330 None SLC6A2, SLC6A3, SLC6A4 4.82465
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIM1, SRC, TEK 4.78234
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.74666
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.74666
[MF] GO:0043560 insulin receptor substrate binding IGF1R, INSR, PIK3CA, PIK3CB 4.68239
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, RORC 4.58709
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 4.49937
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 4.49912
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, ADRA2A, CSNK2A1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SLC6A3, SLC6A4, SMAD3, SRC 4.45194
[MF] GO:0032403 protein complex binding ACHE, ADORA1, ADRA2A, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, SLC6A3, SLC6A4, SMAD3, SRC 4.44386
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 4.40296
[MF] GO:0035240 None DRD2, DRD3, DRD4, SLC6A3 4.395
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.33149
[MF] GO:0042802 identical protein binding ACHE, ADRA2A, AOX1, BCL2, CSNK2A1, DRD2, DRD4, EGFR, ESR1, ESR2, FLT3, GRIK5, IGF1R, KCNH2, KDR, MET, MMP9, NQO2, PTGS2, SLC6A4, SMAD3, TERT, TYR, XDH 4.05079
[MF] GO:0016301 kinase activity AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 4.03353
[MF] GO:0070405 ammonium ion binding ACHE, DRD2, DRD3, DRD4, SLC6A3, SLC6A4 3.83426
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CDK6, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KCNH2, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TERT 3.72342
[MF] GO:0005329 None SLC6A2, SLC6A3, SLC6A4 3.71353
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR, NQO2 3.50518
[MF] GO:0019899 enzyme binding ADRA2A, AURKB, BCL2, CDC25B, CYP1A1, CYP1A2, CYP2A6, CYP2C19, DUSP3, EGFR, ESR1, ESR2, ESRRB, F3, GRM5, HSPA1A, KCNH2, MET, PPARA, PTGS2, PTPN1, SLC6A3, SLC6A4, SMAD3, SRC, TEK, TNKS2 3.41738
[MF] GO:0001591 None DRD2, DRD3, DRD4 3.32194
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.18634
[MF] GO:0008504 None SLC6A2, SLC6A3, SLC6A4 3.17143
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.17143
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.08023
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 2.98191
[MF] GO:0019902 phosphatase binding BCL2, EGFR, MET, PPARA, PTPN1, SLC6A3, SMAD3 2.95211
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.84089
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.84089
[MF] GO:0003845 None HSD11B1, HSD11B2 2.84089
[MF] GO:0008389 None CYP2A13, CYP2A6 2.84089
[MF] GO:0004952 None DRD2, DRD3, DRD4 2.83234
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HSD11B1, HSD11B2, HSD17B1, HSD17B2 2.79049
[MF] GO:0008289 lipid binding AXL, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, HSD11B2, HSD17B1, PPARA, RORC 2.77266
[MF] GO:0042803 protein homodimerization activity ACHE, ADRA2A, AOX1, BCL2, DRD2, FLT3, KCNH2, NQO2, PTGS2, SLC6A4, SMAD3, TERT, TYR, XDH 2.69323
[MF] GO:0097159 organic cyclic compound binding ADORA1, ADRA2A, AOX1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD2, DRD3, DRD4, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC6A3, SLC6A4, SMAD3, SRC, TEK, TERT, XDH 2.68928
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.48868
[MF] GO:0099583 None GRM1, GRM5 2.46373
[MF] GO:0047374 None CES1, CES2 2.46373
[MF] GO:0008392 None CYP2A13, CYP2A6, CYP2C19 2.45001
[MF] GO:0008391 None CYP2A13, CYP2A6, CYP2C19 2.45001
[MF] GO:0003674 molecular_function ACHE, ADORA1, ADORA3, ADRA2A, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CES1, CES2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2D6, DRD2, DRD3, DRD4, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC6A2, SLC6A3, SLC6A4, SMAD3, SRC, TEK, TERT, TNKS, TNKS2, TYR, XDH 2.3724
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.31646
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.31646
[MF] GO:0005328 None SLC6A2, SLC6A3, SLC6A4 2.25966
[MF] GO:0001223 transcription coactivator binding ESR1, PPARA, TERT 2.25966
[MF] GO:0036094 small molecule binding ADORA1, AOX1, AURKB, AXL, CDK6, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SLC1A1, SRC, TEK, XDH 2.23209
[MF] GO:0046983 protein dimerization activity ACHE, ADORA1, ADRA2A, AOX1, AXL, BCL2, DRD2, EGFR, FLT3, KCNH2, NQO2, PTGS2, SLC6A4, SMAD3, TERT, TYR, XDH 2.2162
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.2162
[MF] GO:0004971 None GRIA2, GRIA4 2.2162
[MF] GO:0032795 None ADORA1, ADRA2A 2.2162
[MF] GO:0005326 None SLC1A1, SLC6A2, SLC6A3, SLC6A4 2.21497
[MF] GO:0015370 None SLC1A1, SLC6A2, SLC6A3, SLC6A4 2.21497
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CDC25B, CDK6, CSNK2A1, DUSP3, EGFR, F10, F3, FLT3, IGF1R, INSR, KCNH2, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PTPN1, SRC, TEK 2.0779
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.04747
[MF] GO:0043559 insulin binding IGF1R, INSR 2.04747
[MF] GO:0051380 None ADRA2A, DRD4 2.04747
[MF] GO:0005518 collagen binding ACHE, MMP12, MMP9, SMAD3 2.00025


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 16.8847
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 9.7724
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1, GRM1, EGFR, ESR2, HSPA1A 8.5979
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GRIA2, GPR35, GRIK5, GRM1, ADRA2A, GRM3, GRM5, ADORA3, GRM8, ADORA1, DRD2, DRD3, DRD4, GRIA4 8.5902
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 7.9454
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 7.1564
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, FLT3, MMP1, MMP2, PIK3CB, PTGS2, MMP9, EGFR, IGF1R, CDK6, PIK3CA, BCL2, MET 6.0337
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, INSR, ADORA1, PIK3CB, PTGS2, PTGS1 6.7133
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, EGFR, IGF1R 6.0337
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, PTGS2, CYP2C19 6.8633
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, SRC, INSR, KDR, TEK, PIK3CB, DRD2, MET, EGFR, IGF1R 5.9978
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, GRM1, GRIA4 5.9978
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP2A6, CYP2A13, CYP2D6, CYP1A2, CYP1A1, CYP1B1 6.0337
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, PIK3CA, MMP2, BCL2, PIM1, PIK3CB, F3 5.1923
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, PIK3CA, INSR, GRM8, PIK3CB, GRM1, EGFR 5.2462
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, PTGS2, TYR, CYP2C19, GBA2, CYP19A1, PTGS1, HSD11B1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH, CES1 4.8976
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, INSR, BCL2, TEK, PIK3CB, EGFR, IGF1R 5.1623
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, PIK3CA, BCL2, PIM1, CYP1B1, PTGS2, MMP9, MET, EGFR, CDC25B 4.8719
Melanoma_Homo sapiens_hsa05218 CDK6, PIK3CA, PIK3CB, MET, EGFR, IGF1R 4.9543
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CDK6, PIK3CA, INSR, KDR, BCL2, TEK, PIK3CB, MET, EGFR, IGF1R 4.3963
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, GRIA2, PIK3CA, ADORA1, PIK3CB, DRD2, PPARA, GRIA4 4.4074
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, PIK3CA, INSR, PIK3CB, GRM1, EGFR, IGF1R 4.5535
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, SRC, KDR, BCL2, PIK3CB, MET, EGFR, IGF1R 4.3958
Hepatitis B_Homo sapiens_hsa05161 CDK6, SMAD3, PIK3CA, SRC, BCL2, PIK3CB, MMP9 4.3581
Ras signaling pathway_Homo sapiens_hsa04014 PIK3CA, INSR, KDR, TEK, PIK3CB, MET, EGFR, IGF1R 4.0814
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 4.8897
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, SRC, KDR, PIK3CB, PTGS2 4.1532
Serotonergic synapse_Homo sapiens_hsa04726 CYP2D6, ALOX5, PTGS2, CYP2C19, PTGS1, SLC6A4 4.0498
Glioma_Homo sapiens_hsa05214 CDK6, PIK3CA, PIK3CB, EGFR, IGF1R 4.063
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, INSR, PIK3CB, IGF1R, HSPA1A 4.0814
Pancreatic cancer_Homo sapiens_hsa05212 CDK6, SMAD3, PIK3CA, PIK3CB, EGFR 4.0498
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, DRD2, DRD3, SLC6A3, DRD4, GRIA4 3.7652
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1, ESR2 3.9126
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, PIK3CB, MET, EGFR 4.0398
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP2D6, CYP1A2, AOX1, CYP2C19 3.9901
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, BCL2, PIK3CB, EGFR, IGF1R 3.5445
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, PIK3CA, BCL2, PIK3CB, PTGS2 3.5865
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, INSR, ADORA1, PIK3CB, ADRA2A 3.2385
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, PTGS2, GRM1, GRIA4 3.3066
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, DRD2, GRM1, EGFR 3.5496
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.0709
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, INSR, PIK3CB, PPARA 3.1887
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB, HSPA1A 3.0628
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, ADORA3, BCL2, ADORA1, PIK3CB 3.0454
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1, PIK3CA, PIK3CB, HSPA1A 2.8187
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, PIK3CA, ESRRB, PIK3CB, IGF1R 2.7486
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, AOX1, PIK3CB 2.5611
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, SRC, PIK3CB, PTGS2, EGFR 2.5611
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6, PIK3CA, PIK3CB, EGFR 3.2385
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, PIM1, PIK3CB 3.2269
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, CDC25B, IGF1R 2.465
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB, HSPA1A 2.1582
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6, SMAD3, PIK3CA, PIK3CB 2.8884
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, SRC, PIK3CB, EGFR 2.6299
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.2937
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, PIK3CA, BCL2, PIK3CB 2.2923
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, INSR, PIK3CB, IGF1R 2.5253
Colorectal cancer_Homo sapiens_hsa05210 SMAD3, PIK3CA, BCL2, PIK3CB 3.1119
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2, PIK3CA, INSR, PIK3CB 3.7652
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, PIK3CB, PTGS1 2.1621
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, SRC, PIK3CB, ESR1 2.2083
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 2.794
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.2083
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, PTGS2, CYP2C19, PTGS1 3.1119
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA, EGFR 2.0554
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, INSR, PIK3CB, IGF1R 2.1547
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2, DRD2, SLC6A3 3.4461
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1 3.0579
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, INSR, PIK3CB, PPARA 1.8959
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 2.9743
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PIK3CA, INSR, PIK3CB 2.0115
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.217
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2258
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2369
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.6639
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 3.7433
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.2743
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, PIK3CA, SRC, PIK3CB 1.5085
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 PIK3CA, SRC, PIK3CB, EGFR 1.4558
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.3118
Axon guidance_Homo sapiens_hsa04360 MET 0.3261
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH, CES2, CES1 3.5445
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3336
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB 1.2971
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, CDC25B, HSPA1A 1.2521
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.2108
HTLV-I infection_Homo sapiens_hsa05166 SMAD3, PIK3CA, TERT, PIK3CB 1.2404
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2, HSPA1A 0.6148
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 1.7118
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PIK3CB 1.2521
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, PIK3CB 1.6444
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.3958
Melanogenesis_Homo sapiens_hsa04916 TYR 0.3965
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.5965
Alcoholism_Homo sapiens_hsa05034 DRD2, SLC6A3 0.596
Calcium signaling pathway_Homo sapiens_hsa04020 GRM5, GRM1, EGFR 1.0784
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB, EGFR 1.6189
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, BCL2, PIK3CB 1.4526
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4086
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4077
Parkinson's disease_Homo sapiens_hsa05012 DRD2, SLC6A3 0.7256
Influenza A_Homo sapiens_hsa05164 PIK3CA, PIK3CB, HSPA1A 1.1003
Cell cycle_Homo sapiens_hsa04110 CDK6, SMAD3, CDC25B 1.4199
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.7338
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3, PIK3CA, PIK3CB 1.5943
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.4208
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 0.7476
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, SRC, PIK3CB 1.0424
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.7256
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2 1.6912
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4244
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 0.7567
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4244
Taste transduction_Homo sapiens_hsa04742 GRM1 0.4365
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.4351
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4231
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.4219
Peroxisome_Homo sapiens_hsa04146 XDH 0.4365
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 0.8969
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 0.9076
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.4577
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.4712
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.4692
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB 0.9329
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PIK3CB 0.9727
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 0.9408
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.4807
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, GRIA4 0.9606
Bile secretion_Homo sapiens_hsa04976 CA2 0.4785
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.4831
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 0.994
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, GRM1 2.0554
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 2.0554
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, SLC6A3, GRIA4 2.0426
Shigellosis_Homo sapiens_hsa05131 SRC 0.5021
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5049
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1, IGF1R 2.1547
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.03
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB, EGFR 2.2923
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.1316
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 1.0784
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 1.1793
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.1494
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.5589
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.2538
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, INSR, PIK3CB 2.3774
Malaria_Homo sapiens_hsa05144 MET 0.5965
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.2108
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.604
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.263
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.5989
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.604
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2, BCL2 1.3672
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.4558
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.7106
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7464
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.7857
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.539
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.76
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.7303
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7943
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.753
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.631
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.6912
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2, CYP2C19 1.7537
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7857
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6171
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9404
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.9329
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 4.9678
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0186
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.3145


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)