TCM Prescription: Xun Ma Zhen Pills



Prescription Description
Prescription IDTCMF6598
Pinyin NameXun Ma Zhen Wan
Chinese Name荨麻疹丸
English NameXun Ma Zhen Pills
Function Description荨麻疹, 湿疹
IndicationsEczema, Urticaria
Disease ICD-11 Category EA8Z [Dermatitis or eczema, unspecified, 皮炎或湿疹，未特指 ];
EB0Y [Other specified urticarial disorders, 其他特指的荨麻疹性疾病 ];
Human Tissues Associated with IndicationSkin
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH118 Angelica dahurica 白芷 TCMH118 ITSAK3312-14
TCMH562 Saposhnikovia divaricata 防风 TCMH562 ITSAE3225-14
TCMH112 Dictamnus albus 白藓皮 TCMH112 GBVK982-11
TCMH188 Mentha haplocalyx 薄荷 TCMH188 HM595443
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH1764 Cortex berberidis 三棵针 TCMH1764
TCMH258 Paeonia obovata 赤芍 TCMH258 GBVX7902-15
TCMH2166 Clematis chinensis 威灵仙 TCMH2166
TCMH2134 Smilax glabra 土茯苓 TCMH2134 CPBOL4081-11
TCMH1141 Schizonepeta tenuifolia 荆芥 TCMH1141 ITSAL858-14
TCMH2367 Linum usitatissimum 亚麻子 TCMH2367 PLTOR003-08
TCMH986 Scutellaria baicalensis 黄芩 TCMH986 ITSAP4211-14
TCMH1906 Cimicifuga foetida 升麻 TCMH1906
TCMH1215 Sophora flavescens 苦参 TCMH1215 ITSAM449-14
TCMH865 Carthamus tinctorius 红花 TCMH865 ITSAI2447-14
TCMH819 Polygonum multiflorum 何首乌 TCMH819 ITSAL419-14
TCMH1024 Tribulus terrestris 蒺藜 TCMH1024 ITSAJ4258-14
TCMH1181 Chrysanthemum morifolium 菊花 TCMH1181 KX675020
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT167 AKR1C3 Aldo-keto-reductase family 1 member C3 Oxidoreductase P42330
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT226 PDPK1 3-phosphoinositide dependent protein kinase-1 Kinase O15530
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT230 HSD17B3 Estradiol 17-beta-dehydrogenase 3 Oxidoreductase P37058
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT290 CHRM5 Muscarinic acetylcholine receptor M5 GPCR P08912
TCMT291 CHRM3 Muscarinic acetylcholine receptor M3 GPCR P20309
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT355 CSNK1D Casein kinase I delta Kinase P48730
TCMT359 FYN Tyrosine-protein kinase FYN Kinase P06241
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT417 DYRK2 Dual-specificity tyrosine-phosphorylation regulated kinase 2 Kinase Q92630
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT458 HASPIN Serine/threonine-protein kinase haspin Kinase Q8TF76
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT473 PIM3 Serine/threonine-protein kinase PIM3 Kinase Q86V86
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT678 XIAP Inhibitor of apoptosis protein 3 Transferase P98170
TCMT679 MPEG1 Macrophage-expressed gene 1 protein Unclassified Q2M385
TCMT680 KAT2B Histone acetyltransferase PCAF Transferase Q92831
TCMT683 MIF Macrophage migration inhibitory factor Isomerase P14174
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT725 CACNA1C Voltage-gated L-type calcium channel alpha-1C subunit Ion channel Q13936
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT751 DYRK1A Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kinase Q13627
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT759 SAE1 SUMO-activating enzyme subunit 1 Unclassified Q9UBE0
TCMT763 DYRK3 Dual-specificity tyrosine-phosphorylation regulated kinase 3 Kinase O43781
TCMT783 NR3C2 Mineralocorticoid receptor Nuclear receptor P08235
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT801 TUBB3 Tubulin beta-3 chain Unclassified Q13509
TCMT807 SLC22A12 Solute carrier family 22 member 12 Transporter Q96S37
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT814 CLK1 Dual specificty protein kinase CLK1 Kinase P49759
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT829 NISCH Nischarin Unclassified Q9Y2I1
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT831 DYRK4 Dual specificity tyrosine-phosphorylation-regulated kinase 4 Kinase Q9NR20
TCMT832 DYRK1B Dual specificity tyrosine-phosphorylation-regulated kinase 1B Kinase Q9Y463
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT884 PHF8 Histone lysine demethylase PHF8 Oxidoreductase Q9UPP1
TCMT904 PGR Progesterone receptor Nuclear receptor P06401
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718
TCMT965 KDM7A Lysine-specific demethylase 7 Oxidoreductase Q6ZMT4
TCMT99 SHBG Testis-specific androgen-binding protein Unclassified P04278


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1191 Bacillus megaterium
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1250 Vesicular stomatitis virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1282 Colletotrichum orbiculare
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1293 Vaccinia virus
TCMT1294 Human parainfluenza virus 3
TCMT1296 Influenza A virus H3N2
TCMT1319 Corynebacterium xerosis
TCMT1321 Staphylococcus hominis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, AOX1, APEX1, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM3, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HASPIN, HSD11B1, HSD17B1, HSD17B2, HSD17B3, HSPA1A, IGF1R, INSR, KDR, KIT, MAOA, MET, MIF, MMP1, MMP12, MMP2, MMP9, NISCH, NQO2, NR3C1, NR3C2, NUAK1, PGR, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TYR, XDH 12.3369
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, AOX1, APEX1, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM3, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HASPIN, HSD17B1, HSD17B2, HSD17B3, HSPA1A, IGF1R, INSR, KDR, KIT, MAOA, MET, MIF, MMP1, MMP2, NQO2, NR3C1, NR3C2, NUAK1, PGR, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TYR, XDH 11.6004
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ESR1, FABP3, FABP4, FUT7, HSD11B1, HSD17B1, HSD17B2, HSD17B3, KIT, MET, MIF, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 10.4698
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.2121
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, CLK1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, SRC, TEK 9.98925
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, ADORA1, AKR1B1, AKR1C3, ALOX15, APEX1, AR, AURKB, AXL, CA12, CA2, CA7, CACNA1C, CDK6, CHRM1, CHRM3, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, F10, FABP3, FABP4, FLT3, GPR35, HCAR2, HSD11B1, HSD17B1, HSD17B2, HSD17B3, HSPA1A, INSR, KDR, KIT, MAOA, MET, MIF, NISCH, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 9.98925
[BP] GO:0018212 peptidyl-tyrosine modification AXL, CLK1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, SRC, TEK 9.93892
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, AKR1C3, ALOX15, ALPL, APEX1, AR, AURKB, AXL, CA2, CA9, CACNA1C, CBR1, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, DYRK1A, DYRK1B, DYRK3, EGFR, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B2, HSD17B3, INSR, KDR, KIT, MET, MIF, MMP2, MMP9, PGR, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPRS, RORC, SMAD3, SRC, TEK, TNKS2, TOP2A, TYR 9.82198
[BP] GO:0033559 unsaturated fatty acid metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF, PTGS1, PTGS2 9.79018
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 9.65883
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FUT7, GLO1, HSD17B3, HSPA1A, MIF, NISCH, PIK3CA, PIM1, PPARA, PTGS1, PTGS2, TYR, XDH 9.65883
[BP] GO:0019369 arachidonic acid metabolic process AKR1C3, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 9.63504
[BP] GO:0006690 icosanoid metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF, PTGS1, PTGS2 9.54371
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, AKR1C3, ALOX15, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, FLT3, GPR35, HCAR2, HSPA1A, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 8.82163
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, AKR1C3, ALOX15, AR, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, FLT3, GPR35, HCAR2, HSPA1A, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 8.78518
[BP] GO:0048513 animal organ development ACHE, AKR1C3, AR, AXL, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, HSD17B3, INSR, KDR, KIT, PHF8, PIK3CA, PPARA, PTPRS, SMAD3, SRC, TEK, TYR 8.77528
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, AKR1C3, ALOX15, APEX1, AR, AURKB, AXL, CA2, CA7, CDC25B, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, DYRK1A, DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, PGR, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 8.49066
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, AOX1, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD11B1, HSD17B1, HSD17B2, HSD17B3, MAOA, NQO2, PHF8, PTGS1, PTGS2, TYR, XDH 8.40348
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 8.40348
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AKR1C3, APEX1, AR, AURKB, AXL, CSNK2A1, CYP1B1, DYRK3, EGFR, ESR1, FLT3, GLO1, HCAR2, HSPA1A, IGF1R, KDR, KIT, MET, MIF, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 8.38704
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, AKR1C3, AR, CDC25B, CDK6, CHRM1, CSNK2A1, CYP1B1, EGFR, ESR1, ESRRA, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MIF, MMP12, MMP2, MMP9, NUAK1, PGR, PIM1, PTGS1, PTGS2, SMAD3, SRC, TEK, XDH 8.28919
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AKR1C3, APEX1, AR, AURKB, AXL, CSNK2A1, CYP1B1, DYRK3, EGFR, ESR1, FLT3, GLO1, HCAR2, HSPA1A, IGF1R, KDR, KIT, MET, MIF, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 8.26526
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, AOX1, APEX1, AR, AURKB, AXL, CBR1, CDC25B, CDK6, CHRM1, CHRM3, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HASPIN, HSD11B1, HSD17B1, HSD17B2, HSD17B3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, NISCH, NR3C1, NR3C2, NUAK1, PGR, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TYR, XDH 8.1672
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, AKR1C3, ALPL, APEX1, AR, AXL, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, HSD17B2, IGF1R, INSR, MMP2, MMP9, NR3C1, PIK3CA, PPARA, PTGS2, RORC, SRC, TEK, TYR 8.08112
[BP] GO:0010033 response to organic substance AKR1B1, AKR1C3, ALOX15, ALPL, APEX1, AR, AXL, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MMP2, NR3C1, PIK3CA, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TYR 8.01295
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, ADORA1, AKR1B1, AKR1C3, ALOX15, APEX1, AR, AURKB, AXL, CA2, CA7, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, DYRK1A, DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, NR3C1, PGR, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 8.00958
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, AKR1C3, ALOX15, ALPL, AR, AXL, CA2, CACNA1C, CDK6, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, DYRK1A, DYRK1B, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, HSD17B3, INSR, KDR, KIT, MMP9, PGR, PHF8, PIK3CA, PIM1, PPARA, PTGS2, PTPRS, RORC, SMAD3, SRC, TEK, TYR 7.90071
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, AKR1C3, ALOX15, AR, AURKB, AXL, CSNK2A1, CYP1B1, DUSP3, DYRK1A, DYRK2, DYRK3, EGFR, ESR1, F10, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 7.83198
[BP] GO:0009725 response to hormone AKR1B1, AKR1C3, ALPL, APEX1, AR, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, INSR, KIT, NR3C1, PPARA, PTGS2, SRC, TEK 7.7938
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, AKR1C3, ALOX15, AR, AURKB, AXL, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, DUSP3, DYRK1A, DYRK2, DYRK3, EGFR, ESR1, ESR2, F10, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, NISCH, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 7.7938
[BP] GO:1901568 fatty acid derivative metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, MIF, PTGS1, PTGS2 7.76795
[BP] GO:0046777 protein autophosphorylation AURKB, CLK1, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, KIT, PIM1, SRC, TEK 7.76795
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, APEX1, AURKB, AXL, CDC25B, CDK6, CLK1, CSNK2A1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, PTPRS, SRC, TEK, TNKS, XDH 7.66584
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, AKR1C3, ALOX15, AR, AURKB, AXL, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, DUSP3, DYRK1A, DYRK2, DYRK3, EGFR, ESR1, ESR2, F10, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, NISCH, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 7.65079
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, AOX1, APEX1, AR, AURKB, AXL, CBR1, CDC25B, CDK6, CHRM1, CHRM3, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HASPIN, HSD11B1, HSD17B1, HSD17B2, HSD17B3, HSPA1A, IGF1R, INSR, KDR, KIT, MAOA, MET, MIF, MMP1, MMP12, MMP2, MMP9, NISCH, NR3C1, NR3C2, NUAK1, PGR, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TYR, XDH 7.63334
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, RORC, SRC 7.40044
[BP] GO:0006468 protein phosphorylation AURKB, AXL, CDC25B, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIM1, SRC, TEK, TNKS 7.38819
[BP] GO:0001676 long-chain fatty acid metabolic process AKR1C3, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 7.28201
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AKR1C3, APEX1, AR, AURKB, AXL, CSNK2A1, CYP1B1, DYRK3, EGFR, ESR1, FLT3, GLO1, HCAR2, HSPA1A, IGF1R, KDR, MIF, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A, XDH 7.28201
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, DYRK3, EGFR, GLO1, HSPA1A, IGF1R, KDR, KIT, MET, MIF, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK 7.28201
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, DYRK3, EGFR, GLO1, HSPA1A, IGF1R, KDR, KIT, MET, MIF, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK 7.28201
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, AKR1C3, ALOX15, AR, AXL, CSNK2A1, CYP1B1, EGFR, F10, FLT3, GPR35, HSPA1A, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 7.23647
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, APEX1, AURKB, AXL, CDC25B, CDK6, CLK1, CSNK2A1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, PTPRS, SRC, TEK, TNKS, XDH 7.2072
[BP] GO:0033993 response to lipid AKR1C3, ALPL, AR, AXL, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD17B2, NR3C1, PTGS2, RORC, SRC, TYR 7.2072
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, AKR1C3, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, FABP3, FABP4, FUT7, KIT, MET, MIF, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 7.2072
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AR, AURKB, CHRM1, CHRM3, CHRM5, CLK1, CYP1A1, EGFR, ESR1, FLT3, KIT, MET, MIF, PIK3CB, PIM1, SRC, TEK, TYR 7.13745
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, AKR1C3, ALOX15, AR, AXL, CYP1B1, EGFR, F10, FLT3, GPR35, HSPA1A, INSR, KDR, KIT, MET, MIF, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 7.11146
[BP] GO:0009719 response to endogenous stimulus AKR1B1, AKR1C3, ALPL, APEX1, AR, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, IGF1R, INSR, KIT, MMP2, NR3C1, PPARA, PTGS2, SMAD3, SRC, TEK 7.05987
[BP] GO:0042221 response to chemical ABCB1, AKR1B1, AKR1C3, ALOX15, ALPL, APEX1, AR, AXL, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MMP2, MMP9, NR3C1, PIK3CA, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TYR 6.83306
[BP] GO:0051897 positive regulation of protein kinase B signaling AKR1C3, AXL, EGFR, F10, INSR, KIT, MET, PIK3CA, PIK3CB, SRC, TEK 6.79839
[BP] GO:0006631 fatty acid metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, MIF, PPARA, PTGS1, PTGS2 6.76221
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, ESR1, HSD11B1, HSD17B1, HSD17B2, HSD17B3 6.70516
[BP] GO:0016310 phosphorylation AURKB, AXL, CDC25B, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TNKS 6.4455
[BP] GO:0051896 regulation of protein kinase B signaling AKR1C3, AXL, EGFR, F10, INSR, KIT, MET, PIK3CA, PIK3CB, SRC, TEK, XDH 6.42941
[BP] GO:0014070 response to organic cyclic compound AKR1C3, ALPL, APEX1, AR, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FLT3, NR3C1, PTGS2, RORC, SRC, TEK, TYR 6.42765
[BP] GO:0009755 hormone-mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, RORC, SRC 6.40776
[BP] GO:0030522 intracellular receptor signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, PGR, PIM1, PPARA, RORC, SRC 6.20467
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, AKR1C3, ALOX15, ALPL, APEX1, AR, AXL, CDK6, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MMP2, MMP9, NR3C1, PIK3CA, PTGS2, RORC, SMAD3, SRC 6.20467
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA1, ADORA3, ALOX15, APEX1, AR, AXL, CA2, CA7, CACNA1C, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1B1, DYRK2, EGFR, F10, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, NISCH, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK 6.15888
[BP] GO:0010035 response to inorganic substance AKR1B1, AKR1C3, ALOX15, APEX1, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, KIT, MMP9, PTGS2, SRC 6.13661
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, AKR1C3, ALOX15, AR, AURKB, CDC25B, DYRK1A, DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, NR3C1, PGR, PHF8, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 6.05303
[BP] GO:0007197 None CHRM1, CHRM2, CHRM3, CHRM5 6.04167
[BP] GO:0071310 cellular response to organic substance AKR1B1, AKR1C3, ALOX15, ALPL, APEX1, AR, AXL, CDK6, CYP1A1, CYP1B1, EGFR, ESR1, FABP4, FLT3, IGF1R, INSR, KDR, KIT, MMP2, NR3C1, PIK3CA, PTGS2, RORC, SMAD3, SRC 6.04007
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, CSNK2A1, DYRK3, EGFR, GLO1, HSPA1A, IGF1R, KDR, MIF, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK 6.03544
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD17B1, HSD17B2, HSD17B3 6.00781
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2, HSD17B3 5.85386
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, F10, FLT3, HASPIN, IGF1R, INSR, KDR, KIT, MET, SRC, TEK, TNKS, TOP2A 5.85137
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AKR1C3, AR, CDC25B, CDK6, CHRM1, CSNK2A1, EGFR, ESR1, FLT3, IGF1R, INSR, KDR, KIT, MIF, MMP12, MMP2, MMP9, PIM1, PTGS2, TEK 5.79552
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APEX1, CDK6, CHRM1, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, KIT, MET, MIF, MMP9, NISCH, PTGS2, SMAD3, SRC, TEK 5.74871
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APEX1, CACNA1C, CDK6, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, KIT, MET, MIF, MMP9, NISCH, PTGS2, SMAD3, SRC, TEK 5.72763
[BP] GO:0007207 None CHRM1, CHRM2, CHRM3, CHRM5 5.61162
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APEX1, CDK6, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, KIT, MET, MIF, MMP9, NISCH, PTGS2, SMAD3, SRC, TEK 5.60098
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, ALOX15, APEX1, AR, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1B1, DUSP3, DYRK1A, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GPR35, HCAR2, HSPA1A, IGF1R, KDR, KIT, MET, MIF, MMP12, MMP9, NISCH, NR3C1, PGR, PHF8, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 5.55194
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, RORC 5.541
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, AKR1C3, ALOX15, AR, AXL, CSNK2A1, CYP1B1, EGFR, ESRRA, F10, FABP4, FLT3, GPR35, HSPA1A, INSR, KDR, KIT, MET, MIF, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 5.541
[BP] GO:0009893 positive regulation of metabolic process ADORA1, AKR1C3, ALOX15, AR, AURKB, CDC25B, CSNK2A1, DYRK1A, DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, NR3C1, PGR, PHF8, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 5.52429
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ALOX15, AR, AURKB, CDC25B, CSNK2A1, DYRK1A, DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, NR3C1, PGR, PHF8, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 5.52007
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ALOX15, AR, AURKB, CDC25B, CSNK2A1, DYRK1A, DYRK1B, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, NR3C1, PGR, PHF8, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 5.51034
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, AKR1C3, ALOX15, AR, AURKB, AXL, CSNK2A1, CYP1B1, DUSP3, DYRK1A, DYRK2, DYRK3, EGFR, ESR1, ESR2, F10, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 5.42641
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APEX1, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, KIT, MET, MIF, MMP9, NISCH, PTGS2, SMAD3, SRC, TEK 5.33861
[BP] GO:0048583 regulation of response to stimulus ABCB1, ADORA1, AKR1B1, AKR1C3, ALOX15, AR, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1B1, DUSP3, DYRK1A, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, F10, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 5.2497
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, CACNA1C, CDK6, EGFR, HCAR2, KDR, MIF, PIK3CB, PTGS2, SRC, TNKS, TNKS2 5.21403
[BP] GO:0042446 hormone biosynthetic process AKR1B1, AKR1C3, CYP19A1, HSD11B1, HSD17B1, HSD17B2, HSD17B3 5.1979
[BP] GO:0051716 cellular response to stimulus AKR1B1, AKR1C3, ALOX15, ALPL, APEX1, AR, AURKB, AXL, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, DYRK2, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MIF, MMP2, MMP9, NR3C1, NUAK1, PIK3CA, PTGS2, PTPN1, RORC, SMAD3, SRC, TOP2A 5.18412
[BP] GO:0032787 None AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GLO1, MIF, PPARA, PTGS1, PTGS2 5.18091
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, APEX1, AR, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1B1, DUSP3, DYRK1A, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GPR35, HSPA1A, IGF1R, KDR, KIT, MET, MIF, MMP12, MMP9, NISCH, NR3C1, PHF8, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 5.18091
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, AKR1C3, ALOX15, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD17B1, HSD17B2, HSD17B3, MIF, PIK3CA, PIK3CB, PTGS1, PTGS2 5.18091
[BP] GO:0071407 cellular response to organic cyclic compound AKR1C3, ALPL, APEX1, AR, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, NR3C1, PTGS2, RORC, SRC 5.0928
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC, TEK 4.97589
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, AKR1C3, CHRM5, CYP1A1, FABP3, FLT3, HCAR2, KIT, PPARA, PTGS2, RORC, SRC, TEK 4.9429
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 4.91475
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, AR, AURKB, AXL, CDC25B, CDK6, CHRM1, CHRM3, CLK1, CSNK2A1, CYP1A1, CYP1A2, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, F10, FLT3, FUT7, GLO1, HASPIN, HSPA1A, IGF1R, INSR, KDR, KIT, MAOA, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PHF8, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TYR, XDH 4.9043
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, AKR1C3, CACNA1C, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, HCAR2, HSD11B1, HSD17B1, HSD17B2, HSD17B3 4.88342
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AKR1C3, APEX1, AR, AXL, CDK6, CYP1B1, EGFR, ESR1, IGF1R, INSR, MMP2, MMP9, NR3C1, PIK3CA, PTGS2, RORC, SRC 4.85064
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AKR1C3, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC 4.76086
[BP] GO:0003006 developmental process involved in reproduction AKR1C3, ALPL, AR, AXL, CDC25B, CYP19A1, EGFR, ESR1, ESRRB, HSD17B2, HSD17B3, INSR, KIT, PGR, PTGS2, SRC 4.76086
[BP] GO:0080134 regulation of response to stress ABCB1, ADORA1, CDK6, CYP19A1, DUSP3, DYRK1A, DYRK3, EGFR, ESR1, FABP4, HSPA1A, IGF1R, MET, MIF, MMP12, MMP2, NUAK1, PPARA, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, XDH 4.66294
[BP] GO:0006352 DNA-templated transcription, initiation AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, RORC 4.66012
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, AR, AXL, CACNA1C, CHRM1, CHRM3, CHRM5, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, ESRRB, F10, FABP4, HSD17B2, IGF1R, INSR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TNKS2, TYR 4.5708
[BP] GO:0009987 cellular process ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, AOX1, APEX1, AR, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CBR1, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GLO1, GPR35, HASPIN, HCAR2, HSD17B1, HSD17B2, HSD17B3, HSPA1A, IGF1R, INSR, KDR, KIT, MAOA, MET, MIF, MMP1, MMP12, MMP2, MMP9, NISCH, NQO2, NR3C1, NR3C2, NUAK1, PGR, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TUBB3, TYR, XDH 4.56824
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ALOX15, AR, CDK6, CYP19A1, DUSP3, DYRK1A, DYRK3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PPARA, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, XDH 4.54033
[BP] GO:0019371 None AKR1C3, CBR1, PTGS1, PTGS2 4.45277
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, AKR1C3, AR, AXL, CA1, CA2, CACNA1C, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP1B1, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPR35, HASPIN, HCAR2, IGF1R, INSR, KDR, KIT, MET, MIF, MMP2, MMP9, NISCH, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2 4.43468
[BP] GO:0006464 cellular protein modification process ALPL, AR, AURKB, AXL, CDC25B, CDK6, CHRM1, CHRM3, CLK1, CSNK2A1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, F10, FLT3, FUT7, HASPIN, IGF1R, INSR, KDR, KIT, MET, NUAK1, PHF8, PIK3CA, PIM1, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 4.42194
[BP] GO:0036211 protein modification process ALPL, AR, AURKB, AXL, CDC25B, CDK6, CHRM1, CHRM3, CLK1, CSNK2A1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, F10, FLT3, FUT7, HASPIN, IGF1R, INSR, KDR, KIT, MET, NUAK1, PHF8, PIK3CA, PIM1, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 4.42194
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, AR, CDC25B, CHRM5, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, KIT, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.41343
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ALOX15, AR, CDC25B, EGFR, ESRRB, FABP3, FLT3, INSR, KDR, KIT, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.37824
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ALOX15, AR, CDC25B, EGFR, ESRRB, FABP3, FLT3, INSR, KDR, KIT, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.37824
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ALOX15, AR, CDC25B, CHRM5, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, KIT, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.35488
[BP] GO:0043412 macromolecule modification ALPL, APEX1, AR, AURKB, AXL, CDC25B, CDK6, CHRM1, CHRM3, CLK1, CSNK2A1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, F10, FLT3, FUT7, HASPIN, IGF1R, INSR, KDR, KIT, MET, NR3C1, NUAK1, PHF8, PIK3CA, PIM1, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 4.35301
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, DYRK1A, EGFR, ESR1, KIT, PGR, PPARA, RORC, SRC, TOP2A 4.33437
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 4.33331
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, ALOX15, ALPL, APEX1, AR, AURKB, AXL, CA2, CA6, CA9, CDK6, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DYRK2, EGFR, ESR1, ESRRA, F10, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, KIT, MIF, MMP12, MMP2, MMP9, NR3C1, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TYR 4.32146
[BP] GO:0044267 cellular protein metabolic process ALPL, AR, AURKB, AXL, CDC25B, CDK6, CHRM1, CHRM3, CLK1, CSNK2A1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, F10, FLT3, FUT7, HASPIN, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP2, NUAK1, PHF8, PIK3CA, PIM1, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 4.23584
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, AR, EGFR, FLT3, INSR, KDR, KIT, MIF, PIK3CB, PTPN1, SRC, TEK, XDH 4.14686
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK 4.14686
[BP] GO:0010907 None DYRK2, ESRRB, INSR, PPARA, SRC 3.97657
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, AR, DUSP3, DYRK1A, DYRK3, EGFR, ESR1, ESR2, GPR35, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PTGS2, PTPN1, PTPRS, SMAD3, SRC, XDH 3.93756
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, AR, DUSP3, DYRK1A, DYRK3, EGFR, ESR1, ESR2, GPR35, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PTGS2, PTPN1, PTPRS, SMAD3, SRC, XDH 3.91983
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AKR1C3, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 3.91983
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, AR, CDC25B, EGFR, ESRRB, FLT3, INSR, KDR, KIT, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 3.87096
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ALOX15, AR, DUSP3, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MIF, PIK3CB, PTPN1, SRC, TEK, XDH 3.81571
[BP] GO:0071248 cellular response to metal ion AKR1C3, ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 3.81571
[BP] GO:0006940 None ADORA1, CHRM1, CHRM2, CHRM3, KIT, PTGS2 3.81571
[BP] GO:0007213 None CHRM1, CHRM2, CHRM3, CHRM5 3.80122
[BP] GO:0061370 testosterone biosynthetic process AKR1C3, CYP19A1, HSD17B3 3.7598
[BP] GO:0046456 icosanoid biosynthetic process ALOX15, ALOX5, MIF, PTGS1, PTGS2 3.75427
[BP] GO:0019538 protein metabolic process ACHE, ALPL, AR, AURKB, AXL, CDC25B, CDK6, CHRM1, CHRM3, CLK1, CSNK2A1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, F10, FLT3, FUT7, HASPIN, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PHF8, PIK3CA, PIM1, PPARA, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 3.68226
[BP] GO:0042180 None AKR1B1, AKR1B10, AKR1C3, CYP19A1, GLO1, HSD17B3 3.67732
[BP] GO:0048608 reproductive structure development AKR1C3, AR, AXL, CYP19A1, ESR1, HSD17B2, HSD17B3, INSR, KIT, SRC 3.67732
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, FLT3, IGF1R, INSR, KIT, MIF, PIK3CB, PTPN1, SRC 3.63657
[BP] GO:0009891 positive regulation of biosynthetic process AR, AURKB, DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, INSR, KDR, MET, MMP12, NR3C1, PGR, PHF8, PPARA, PTGS2, RORC, SMAD3, SRC, TNKS, TNKS2, TOP2A 3.6165
[BP] GO:0006979 response to oxidative stress AKR1B1, AKR1C3, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, PTGS1, PTGS2, SRC 3.60462
[BP] GO:1903725 regulation of phospholipid metabolic process CHRM5, FABP3, FLT3, KIT, SRC, TEK 3.58209
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, AR, CDC25B, EGFR, FLT3, INSR, KDR, KIT, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 3.55449
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, NQO2, PTGS1, RORC 3.54384
[BP] GO:0048545 response to steroid hormone AKR1C3, ALPL, AR, CA2, EGFR, FLT3, NR3C1, PTGS2, SRC 3.53817
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CDK6, CYP1B1, EGFR, KDR, NR3C1, PTGS2, SRC 3.53074
[BP] GO:0071383 None AKR1C3, AR, EGFR, FLT3, NR3C1, SRC 3.52291
[BP] GO:0019752 carboxylic acid metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GLO1, MIF, PIM1, PPARA, PTGS1, PTGS2, TYR 3.5026
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, KIT, SRC, TEK 3.46175
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, AKR1C3, APEX1, AR, EGFR, ESR1, FLT3, IGF1R, INSR, KIT, MMP2, NR3C1, PTGS2, SMAD3, SRC 3.44329
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, EGFR, HCAR2, PIK3CB, PTGS2, TNKS, TNKS2 3.44144
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, AR, CDC25B, DUSP3, EGFR, ESRRB, FABP4, FLT3, IGF1R, INSR, KDR, KIT, MIF, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, TEK, XDH 3.43536
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, AKR1C3, ALOX15, APEX1, AR, AURKB, CA9, CDC25B, CHRM5, CLK1, CSNK2A1, CYP1A1, CYP1B1, DUSP3, DYRK1A, DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, HCAR2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, NR3C1, NR3C2, NUAK1, PGR, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 3.41804
[BP] GO:1902532 negative regulation of intracellular signal transduction DUSP3, DYRK1A, DYRK3, ESR1, HSPA1A, IGF1R, MET, MIF, MMP9, PTGS2, PTPN1, SRC, XDH 3.41177
[BP] GO:0030518 intracellular steroid hormone receptor signaling pathway AR, ESR1, ESR2, NR3C1, PGR, SRC 3.40975
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, AKR1C3, ALOX15, APEX1, AR, AURKB, CA9, CDC25B, CDK6, CHRM5, CLK1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, DYRK1A, DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, HCAR2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, NR3C1, NR3C2, NUAK1, PGR, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 3.40327
[BP] GO:0071241 cellular response to inorganic substance AKR1C3, ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 3.39632
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, AR, AXL, CA2, CACNA1C, CDK6, CHRM1, CHRM2, CHRM3, CYP1B1, EGFR, ESR1, ESRRA, ESRRB, GPR35, HCAR2, HSPA1A, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, PIK3CA, PIM1, PTGS2, PTPRS, SMAD3, SRC, TEK, TNKS2, XDH 3.38491
[BP] GO:0030335 positive regulation of cell migration EGFR, F10, IGF1R, INSR, KDR, KIT, MET, MMP9, PTGS2, SMAD3, SRC, TEK 3.37568
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AKR1C3, APEX1, AXL, CYP1B1, EGFR, MMP9, SRC 3.36727
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, KIT, PPARA, PTGS2, SRC, TEK 3.36595
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, AOX1, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, EGFR, HSPA1A, MAOA 3.33486
[BP] GO:0006694 steroid biosynthetic process AKR1B1, AKR1C3, CYP19A1, HSD11B1, HSD17B1, HSD17B2, HSD17B3 3.30577
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.30577
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.30496
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.30496
[BP] GO:0031328 positive regulation of cellular biosynthetic process AR, AURKB, DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, INSR, MET, MMP12, NR3C1, PGR, PHF8, PPARA, PTGS2, RORC, SMAD3, SRC, TNKS, TNKS2, TOP2A 3.28818
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process AR, AURKB, DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, IGF1R, INSR, KDR, MET, MMP12, NR3C1, PGR, PHF8, PPARA, RORC, SMAD3, SRC, TNKS, TNKS2, TOP2A 3.28521
[BP] GO:2000147 positive regulation of cell motility EGFR, F10, IGF1R, INSR, KDR, KIT, MET, MMP9, PTGS2, SMAD3, SRC, TEK 3.24421
[BP] GO:0095500 None CHRM1, CHRM2, CHRM3, CHRM5 3.22633
[BP] GO:1903831 None CHRM1, CHRM2, CHRM3, CHRM5 3.22633
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 3.2076
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.15271
[BP] GO:0051272 positive regulation of cellular component movement EGFR, F10, IGF1R, INSR, KDR, KIT, MET, MMP9, PTGS2, SMAD3, SRC, TEK 3.13087
[BP] GO:0010038 response to metal ion AKR1C3, ALOX15, CA2, CYP1A1, CYP1A2, EGFR, FABP4, KIT, MMP9, PTGS2 3.12846
[BP] GO:0044598 None AKR1B1, AKR1B10, AKR1C3 3.12714
[BP] GO:0044597 None AKR1B1, AKR1B10, AKR1C3 3.12714
[BP] GO:0030638 None AKR1B1, AKR1B10, AKR1C3 3.12714
[BP] GO:0022414 reproductive process AKR1B1, AKR1C3, ALPL, AR, AXL, CDC25B, CYP19A1, CYP1A1, EGFR, ESR1, ESRRB, HSD17B2, HSD17B3, INSR, KIT, MMP2, MMP9, PGR, PTGS2, SRC, TOP2A 3.11813
[BP] GO:0010676 None DYRK2, ESRRB, INSR, PPARA, SRC 3.11813
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process AKR1C3, EGFR, INSR, PTGS2, SMAD3, XDH 3.10587
[BP] GO:0080135 regulation of cellular response to stress CDK6, DUSP3, DYRK1A, DYRK3, EGFR, HSPA1A, IGF1R, MET, MIF, NUAK1, PTGS2, PTPN1, PTPRS, XDH 3.08723
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process AR, AURKB, DYRK1B, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, IGF1R, INSR, MET, MMP12, NR3C1, PGR, PHF8, PPARA, PTPN1, RORC, SMAD3, SRC, TNKS, TNKS2, TOP2A 3.05545
[BP] GO:0006693 None AKR1C3, MIF, PTGS1, PTGS2 3.03355
[BP] GO:0006692 None AKR1C3, MIF, PTGS1, PTGS2 3.03355
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ALOX15, AR, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, KIT, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 3.02341
[BP] GO:0043436 oxoacid metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GLO1, MIF, PIM1, PPARA, PTGS1, PTGS2, TYR 3.02341
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, ALOX15, APEX1, AR, AURKB, CA9, CDC25B, CDK6, CHRM5, CLK1, CSNK2A1, CYP1A2, CYP1B1, DUSP3, DYRK1A, DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP4, FLT3, GLO1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, NR3C1, NR3C2, NUAK1, PGR, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 3.02087
[BP] GO:0051049 regulation of transport ABCB1, ACHE, ADORA1, ALOX15, AXL, CA2, CA7, CACNA1C, CHRM1, CYP19A1, DYRK2, EGFR, GPR35, HCAR2, HSPA1A, INSR, MIF, MMP12, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC 3.00884
[BP] GO:0040017 positive regulation of locomotion EGFR, F10, IGF1R, INSR, KDR, KIT, MET, MMP9, PTGS2, SMAD3, SRC, TEK 3.00884
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ALOX15, AR, CDC25B, CSNK2A1, DYRK1A, EGFR, ESR1, FLT3, HSPA1A, INSR, KDR, KIT, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 2.99588
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway HSPA1A, MIF, MMP9, PTGS2, PTPN1, SRC 2.99335
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, EGFR, FLT3, INSR, KIT, MIF, PIK3CB, PTPN1, SRC 2.98971
[BP] GO:0046686 response to cadmium ion AKR1C3, CYP1A2, EGFR, KIT, MMP9 2.98648
[BP] GO:0030647 None AKR1B1, AKR1B10, AKR1C3 2.98646
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, AKR1C3, ALOX15, APEX1, AR, AURKB, CA9, CDC25B, CHRM5, CLK1, CSNK2A1, CYP1B1, DUSP3, DYRK1A, DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, NR3C1, NR3C2, NUAK1, PGR, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 2.98646
[BP] GO:0007271 None CHRM1, CHRM2, CHRM3, CHRM5 2.98646
[BP] GO:0010906 None DYRK2, ESRRB, INSR, PPARA, RORC, SRC 2.97741
[BP] GO:0006082 organic acid metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GLO1, MIF, PIM1, PPARA, PTGS1, PTGS2, TYR 2.9442
[BP] GO:0065007 biological regulation ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, ALOX15, APEX1, AR, AURKB, AXL, CA1, CA12, CA2, CA7, CA9, CACNA1C, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, GLO1, GPR35, HASPIN, HCAR2, HSD11B1, HSD17B1, HSD17B2, HSD17B3, HSPA1A, IGF1R, INSR, KDR, KIT, MAOA, MET, MIF, MMP1, MMP12, MMP2, MMP9, NISCH, NR3C1, NR3C2, NUAK1, PGR, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 2.94379
[BP] GO:0009968 negative regulation of signal transduction AR, DUSP3, DYRK1A, DYRK3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MIF, MMP12, MMP9, PTGS2, PTPN1, PTPRS, SMAD3, SRC, XDH 2.90854
[BP] GO:0032870 cellular response to hormone stimulus AKR1C3, APEX1, AR, EGFR, ESR1, FLT3, INSR, KIT, NR3C1, SRC 2.90583
[BP] GO:0008217 None ADORA1, AR, NISCH, PPARA, PTGS1, PTGS2, SMAD3 2.90416
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, HASPIN, TNKS, TNKS2 2.89127
[BP] GO:0031399 regulation of protein modification process ADORA1, ALOX15, AR, CDC25B, DUSP3, DYRK1A, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 2.89113
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ALOX15, AR, CDC25B, DYRK1A, EGFR, ESR1, FLT3, HSPA1A, INSR, KDR, KIT, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 2.88882
[BP] GO:0048869 cellular developmental process ACHE, AKR1C3, ALPL, AR, AXL, CBR1, CDC25B, CDK6, CYP1A1, DYRK3, EGFR, ESR1, ESRRB, FABP4, FLT3, FUT7, GLO1, KDR, KIT, MET, MIF, MMP2, MMP9, PGR, PTGS2, PTPRS, RORC, SMAD3, SRC, TEK, TOP2A 2.88373
[BP] GO:0006636 unsaturated fatty acid biosynthetic process ALOX15, MIF, PTGS1, PTGS2 2.87682
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, EGFR, FLT3, INSR, KIT, MIF, PIK3CA, PIK3CB, PTPN1, SRC, TEK, TNKS 2.87433
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7 2.86118
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.86118
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, EGFR, ESR1, FABP4, HSPA1A, MMP12, MMP2, PPARA, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK 2.83198
[BP] GO:0001952 regulation of cell-matrix adhesion CDK6, KDR, PIK3CB, SMAD3, SRC, TEK 2.82922
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, KIT, SRC, TEK 2.82922
[BP] GO:0031960 response to corticosteroid AKR1C3, ALPL, EGFR, FLT3, NR3C1, PTGS2, SRC 2.81711
[BP] GO:0003018 None ADORA1, CHRM1, CHRM3, EGFR, PTGS2, SRC, TEK 2.81711
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ALOX15, AR, CDC25B, DYRK1A, EGFR, FLT3, INSR, KDR, KIT, MIF, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 2.81628
[BP] GO:0071396 cellular response to lipid AKR1C3, AR, AXL, CDK6, EGFR, ESR1, FLT3, NR3C1, RORC, SRC 2.79583
[BP] GO:0044057 None ADORA1, ADORA3, CACNA1C, CHRM1, CHRM2, CHRM3, EGFR, GPR35, HCAR2, KIT, PTGS2, SMAD3 2.79428
[BP] GO:0009892 negative regulation of metabolic process ADORA1, AKR1C3, APEX1, AR, AURKB, CSNK2A1, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, FABP4, HCAR2, HSPA1A, IGF1R, KDR, MET, MIF, MMP12, MMP9, NR3C1, PGR, PIK3CA, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TNKS, TNKS2, XDH 2.79044
[BP] GO:0071276 cellular response to cadmium ion AKR1C3, CYP1A2, EGFR, MMP9 2.78188
[BP] GO:0048731 system development ACHE, ADORA1, ALPL, CACNA1C, CHRM1, CHRM2, CHRM3, DYRK1A, HSD17B3, MMP9, PIK3CA, SMAD3, SRC, TEK 2.77414
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 2.77414
[BP] GO:0006721 terpenoid metabolic process AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1, EGFR 2.75427
[BP] GO:0060736 prostate gland growth AR, CYP19A1, ESR1 2.74938
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, NISCH 2.73583
[BP] GO:0006937 None ADORA1, CACNA1C, CHRM1, CHRM2, CHRM3, KIT, PTGS2 2.73056
[BP] GO:0051338 regulation of transferase activity ADORA1, AURKB, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KIT, MIF, PIK3CA, PIK3CB, PTPN1, SRC, TEK, TNKS 2.71595
[BP] GO:0090218 positive regulation of lipid kinase activity FLT3, KIT, SRC, TEK 2.69672
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AKR1C3, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FUT7, HSPA1A, MAOA, MMP1, MMP12, MMP2, MMP9, PIK3CB, SRC, XDH 2.69672
[BP] GO:0016488 None AKR1B10, AKR1C3 2.69672
[BP] GO:0016487 None AKR1B10, AKR1C3 2.69672
[BP] GO:0016107 None AKR1B10, AKR1C3 2.69672
[BP] GO:0009115 None AOX1, XDH 2.69672
[BP] GO:0006714 None AKR1B10, AKR1C3 2.69672
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APEX1, AXL, CA12, CA2, CA7, CACNA1C, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, INSR, MET, PIK3CA, PIK3CB, SMAD3, SRC 2.67184
[BP] GO:0090257 None ADORA1, CACNA1C, CHRM1, CHRM2, CHRM3, KIT, PTGS2, SMAD3 2.66843
[BP] GO:0045913 None DYRK2, ESRRB, INSR, PPARA, SRC 2.65692
[BP] GO:0001503 ossification ALOX15, ALPL, EGFR, MMP2, MMP9, TEK 2.63181
[BP] GO:2000377 regulation of reactive oxygen species metabolic process AKR1C3, CYP1B1, EGFR, INSR, PTGS2, SMAD3, XDH 2.62572
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, EGFR, FLT3, INSR, KIT, MIF, PIK3CA, PIK3CB, PTPN1, SRC, TEK 2.61021
[BP] GO:0042493 response to drug ABCB1, AKR1B1, APEX1, AXL, CA9, CDK6, CYP1A1, CYP1B1, EGFR, FABP3, KDR, NR3C1, PTGS2, SRC 2.59864
[BP] GO:0044093 positive regulation of molecular function ABCB1, ADORA1, AR, AURKB, CDC25B, EGFR, ESR1, ESR2, FLT3, HSPA1A, INSR, KIT, MET, MIF, MMP9, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 2.5799
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.55827
[BP] GO:0001516 None MIF, PTGS1, PTGS2 2.55827
[BP] GO:0046457 None MIF, PTGS1, PTGS2 2.55827
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 2.55228
[BP] GO:1901796 None AURKB, CSNK2A1, DYRK1A, DYRK2, DYRK3, MIF, NUAK1 2.52567
[BP] GO:0043549 regulation of kinase activity ADORA1, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KIT, MIF, PIK3CA, PIK3CB, PTPN1, SRC, TEK 2.52455
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, AR, AURKB, AXL, ESR1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2 2.51557
[BP] GO:0048732 gland development AR, CSNK2A1, CYP19A1, EGFR, INSR, PIK3CA, SMAD3, TYR 2.5082
[BP] GO:0010675 None DYRK2, ESRRB, INSR, PPARA, RORC, SRC 2.50668
[BP] GO:1901654 None AKR1B1, AR, CA9, CSNK2A1, EGFR, NR3C1, SRC 2.50254
[BP] GO:0007346 regulation of mitotic cell cycle APEX1, AURKB, CDC25B, CDK6, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3, TNKS, TOP2A 2.49205
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, CYP1A1, EGFR, PPARA, SMAD3 2.49205
[BP] GO:0048806 genitalia development AXL, CYP19A1, ESR1, HSD17B3 2.49205
[BP] GO:0002682 regulation of immune system process ADORA1, ALOX15, AXL, CA2, CDK6, CYP19A1, DUSP3, ESR1, ESRRA, HCAR2, HSPA1A, KIT, MIF, MMP12, MMP2, PIK3CA, PIK3CB, PTPN1, PTPRS, SMAD3, SRC 2.49057
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.47518
[BP] GO:0043518 None DYRK1A, DYRK3, MIF 2.47518
[BP] GO:0007193 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5 2.46008
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, PTGS2 2.46008
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1, EGFR 2.44501
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC, TEK 2.44501
[BP] GO:0006807 nitrogen compound metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALPL, AOX1, APEX1, AR, AURKB, AXL, CDC25B, CDK6, CHRM1, CHRM3, CLK1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FLT3, FUT7, GLO1, HASPIN, HSPA1A, IGF1R, INSR, KDR, KIT, MAOA, MET, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, NUAK1, PGR, PHF8, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TYR, XDH 2.44501
[BP] GO:0001101 response to acid chemical AKR1B1, AKR1C3, EGFR, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC 2.44144
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALOX15, CSNK2A1, EGFR, FABP3, FABP4, KIT, MET, PIK3CA, PIK3CB 2.41714
[BP] GO:0018107 peptidyl-threonine phosphorylation CLK1, CSNK2A1, DYRK1A, HASPIN, TNKS 2.4135
[BP] GO:0045725 None DYRK2, ESRRB, INSR 2.39277
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, PTGS2, SMAD3 2.37929
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.37929
[BP] GO:0010810 regulation of cell-substrate adhesion ALOX15, CDK6, KDR, PIK3CB, SMAD3, SRC, TEK 2.3782
[BP] GO:0050678 None AR, CDK6, EGFR, KDR, MMP12, PGR, SMAD3, TEK, XDH 2.36966
[BP] GO:1901570 None ALOX15, ALOX5, MIF, PTGS1, PTGS2 2.36953
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, EGFR, ESR1, FABP4, KDR, MET, MIF, MMP12, PPARA, PTGS2, PTPRS, SMAD3, TEK 2.35038
[BP] GO:1901655 None AKR1B1, AR, EGFR, NR3C1, SRC 2.34617
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, AKR1C3, ALOX15, CYP19A1, CYP1A1, CYP1B1, HSD17B3, MAOA, TYR 2.34265
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK 2.33844
[BP] GO:2000106 regulation of leukocyte apoptotic process AURKB, AXL, HCAR2, MIF, PIK3CB 2.3278
[BP] GO:0044070 regulation of anion transport ABCB1, ADORA1, CA2, CA7, MIF 2.3278
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, PTGS2, TYR 2.3278
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, DUSP3, EGFR, FLT3, IGF1R, INSR, KIT, MIF, PIK3CB, PTPN1, SRC 2.3278
[BP] GO:0045859 regulation of protein kinase activity ADORA1, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KIT, MIF, PIK3CA, PIK3CB, PTPN1, SRC 2.32523
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.32523
[BP] GO:0070875 None DYRK2, ESRRB, INSR 2.32523
[BP] GO:0019372 lipoxygenase pathway ALOX15, ALOX5, PTGS2 2.32523
[BP] GO:0043551 regulation of phosphatidylinositol 3-kinase activity FLT3, KIT, SRC, TEK 2.31661
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, AR, AURKB, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KIT, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 2.30619
[BP] GO:0060748 None AR, PGR 2.30619
[BP] GO:0046110 None AOX1, XDH 2.30619
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.30619
[BP] GO:0002520 None CACNA1C, SMAD3 2.30619
[BP] GO:0016095 None AKR1B10, AKR1C3 2.30619
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, ALOX15, APEX1, AR, AURKB, AXL, CA1, CA2, CA7, CA9, CACNA1C, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, GLO1, GPR35, HASPIN, HCAR2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP1, MMP12, MMP2, MMP9, NISCH, NR3C1, NR3C2, NUAK1, PGR, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 2.28273
[BP] GO:0018210 peptidyl-threonine modification CLK1, CSNK2A1, DYRK1A, HASPIN, TNKS 2.2726
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK 2.27158
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, EGFR, FLT3, INSR, KIT, MIF, PIK3CA, PIK3CB, PTPN1, SRC 2.26581
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.26027
[BP] GO:0001954 positive regulation of cell-matrix adhesion CDK6, KDR, SMAD3, TEK 2.25597
[BP] GO:0044259 multicellular organismal macromolecule metabolic process AKR1C3, MMP1, MMP12, MMP2, MMP9 2.2542
[BP] GO:0051254 None AR, DYRK1B, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, INSR, MET, MMP12, NR3C1, PGR, PHF8, PPARA, RORC, SMAD3, SRC, TNKS, TOP2A 2.24484
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, AKR1C3, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.24484
[BP] GO:0007200 None CHRM1, CHRM2, CHRM3, CHRM5, ESR1 2.23397
[BP] GO:0009894 regulation of catabolic process ADORA1, APEX1, CSNK2A1, EGFR, ESRRB, HCAR2, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PPARA, PTPN1, SMAD3 2.23397
[BP] GO:1901652 response to peptide AKR1B1, APEX1, FABP3, IGF1R, INSR, PPARA, PTGS2, SRC, TEK 2.22604
[BP] GO:0090087 None ACHE, ADORA1, CA2, CACNA1C, CHRM1, DYRK2, EGFR, HCAR2, MIF, MMP12, PTGS2, PTPN1, SMAD3, SRC 2.22361
[BP] GO:0010638 positive regulation of organelle organization ALOX15, AURKB, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK, TNKS, TNKS2 2.21466
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, EGFR, FLT3, INSR, KIT, MIF, PIK3CB, PTPN1, SRC 2.21177
[BP] GO:0050900 leukocyte migration FUT7, KIT, MIF, MMP1, MMP9, PIK3CA, PIK3CB, SRC, TEK 2.21177
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, DUSP3, EGFR, KDR, MIF, PTPN1, SRC, TEK 2.20971
[BP] GO:0006954 inflammatory response ADORA1, ADORA3, ALOX15, AXL, KIT, MIF, PIK3CA, PIK3CB, PTGS1, PTGS2 2.20895
[BP] GO:0016137 None AKR1B1, AKR1B10, AKR1C3 2.19976
[BP] GO:0003013 None ADORA1, CHRM1, CHRM3, EGFR, PTGS2, SRC, TEK 2.19587
[BP] GO:0065009 regulation of molecular function ABCB1, ADORA1, ADORA3, AR, AURKB, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, ESR2, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, KIT, MET, MIF, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 2.1852
[BP] GO:0044283 None AKR1B1, AKR1C3, ALOX15, ALOX5, CYP19A1, CYP1A1, HSD17B3, MIF, PTGS1, PTGS2 2.18197
[BP] GO:0002009 morphogenesis of an epithelium AR, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.13466
[BP] GO:2001234 negative regulation of apoptotic signaling pathway AR, HSPA1A, MIF, MMP9, PTGS2, PTPN1, SRC 2.12586
[BP] GO:0016477 cell migration AXL, CYP1B1, EGFR, FUT7, KDR, KIT, MIF, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC, TEK 2.11449
[BP] GO:0051726 regulation of cell cycle APEX1, AURKB, CDC25B, CDK6, CSNK2A1, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, MIF, PIM1, PTGS2, SMAD3, SRC, TNKS, TOP2A 2.10854
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CSNK2A1, CYP1B1, DUSP3, ESR1, FABP4, GPR35, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC, TNKS 2.10854
[BP] GO:1903522 None ADORA1, ADORA3, CACNA1C, CHRM1, CHRM2, CHRM3, EGFR, PTGS2 2.10854
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, EGFR, IGF1R, INSR, SRC, TNKS, TNKS2 2.10594
[BP] GO:0048878 chemical homeostasis AKR1B1, CA12, CA2, CA7, CACNA1C, EGFR, ESR1, FABP3, FABP4, GPR35, INSR, MET, PIK3CA, PIK3CB, SMAD3 2.10525
[BP] GO:0035556 intracellular signal transduction AKR1B1, AXL, CACNA1C, CYP1B1, DYRK2, EGFR, HASPIN, IGF1R, INSR, KDR, KIT, MET, MIF, NISCH, NUAK1, PIK3CA, PIK3CB, PTPN1, SRC, TEK 2.09862
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, ALOX15, APEX1, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DYRK2, EGFR, HSPA1A, KIT, MIF, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A 2.08499
[BP] GO:0045893 None AR, DYRK1B, EGFR, ESR1, ESR2, ESRRA, ESRRB, INSR, MET, MMP12, NR3C1, PGR, PHF8, PPARA, RORC, SMAD3, SRC, TNKS, TOP2A 2.07822
[BP] GO:1903508 None AR, DYRK1B, EGFR, ESR1, ESR2, ESRRA, ESRRB, INSR, MET, MMP12, NR3C1, PGR, PHF8, PPARA, RORC, SMAD3, SRC, TNKS, TOP2A 2.07822
[BP] GO:0051240 positive regulation of multicellular organismal process AR, AXL, CA2, CHRM3, CYP1B1, EGFR, ESRRB, HCAR2, HSPA1A, KDR, KIT, MET, MIF, MMP12, MMP9, PIM1, PTGS2, SMAD3, SRC, TEK 2.07636
[BP] GO:1902680 None AR, DYRK1B, EGFR, ESR1, ESR2, ESRRA, ESRRB, INSR, MET, MMP12, NR3C1, PGR, PHF8, PPARA, RORC, SMAD3, SRC, TNKS, TOP2A 2.07636
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, ALOX15, APEX1, AR, AURKB, CA9, CDC25B, CLK1, CSNK2A1, CYP1B1, DUSP3, DYRK1A, DYRK1B, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, GLO1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MIF, MMP12, MMP9, NR3C1, NR3C2, NUAK1, PGR, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 2.07279
[BP] GO:0045787 positive regulation of cell cycle APEX1, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, INSR, MIF, SRC 2.06158
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK 2.06158
[BP] GO:0033031 positive regulation of neutrophil apoptotic process HCAR2, PIK3CB 2.06158
[BP] GO:0070213 None TNKS, TNKS2 2.06158
[BP] GO:0006145 None AOX1, XDH 2.06158
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.06158
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.06158
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.05903
[BP] GO:0043550 regulation of lipid kinase activity FLT3, KIT, SRC, TEK 2.05903
[BP] GO:0014066 regulation of phosphatidylinositol 3-kinase signaling EGFR, FLT3, KDR, KIT, TEK 2.05791
[BP] GO:0016101 None AKR1B10, AKR1C3, CYP1A1, CYP1B1, EGFR 2.05791
[BP] GO:0051050 positive regulation of transport ABCB1, ACHE, ADORA1, AXL, CA2, CHRM1, CYP19A1, EGFR, HCAR2, INSR, MIF, MMP12, PTGS2, SMAD3, SRC 2.03308
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.03284
[BP] GO:0048146 positive regulation of fibroblast proliferation CDK6, EGFR, ESR1, MIF 2.03284
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.03284
[BP] GO:0046854 phosphatidylinositol phosphorylation EGFR, KIT, MET, PIK3CA, PIK3CB 2.0224
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.00622
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.00622
[BP] GO:0000904 cell morphogenesis involved in differentiation AR, AXL, MET, SRC, TEK 2.00596
[BP] GO:0051128 regulation of cellular component organization ALOX15, AR, AURKB, AXL, CSNK2A1, EGFR, ESR1, ESR2, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP9, PHF8, PIK3CB, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 2.00453
[CC] GO:0043227 membrane-bounded organelle ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALPL, AOX1, APEX1, AR, AURKB, AXL, CA1, CA2, CA4, CA5A, CA5B, CA6, CBR1, CDK6, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GLO1, HASPIN, HSD17B3, HSPA1A, IGF1R, INSR, KDR, KIT, MAOA, MIF, MMP12, MMP2, MMP9, NISCH, NQO2, NR3C1, NUAK1, PHF8, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SHBG, SMAD3, SRC, TNKS, TNKS2, TOP2A, TUBB3, TYR, XDH 3.04034
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, AOX1, APEX1, AR, AURKB, CA1, CA2, CA4, CA5A, CA5B, CA7, CACNA1C, CBR1, CDC25B, CDK6, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, DYRK2, DYRK3, EGFR, ESR1, ESR2, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B1, HSD17B2, HSD17B3, HSPA1A, INSR, KDR, KIT, MAOA, MIF, MMP2, MMP9, NISCH, NQO2, NR3C1, NR3C2, PGR, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 2.86536
[CC] GO:0043226 organelle ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALPL, AOX1, APEX1, AR, AURKB, AXL, CA1, CA2, CA4, CA5A, CA5B, CA6, CA9, CACNA1C, CBR1, CDK6, CHRM1, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GLO1, HASPIN, HSD17B3, HSPA1A, IGF1R, INSR, KDR, KIT, MAOA, MIF, MMP12, MMP2, MMP9, NISCH, NQO2, NR3C1, NUAK1, PHF8, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SHBG, SMAD3, SRC, TNKS, TNKS2, TOP2A, TUBB3, TYR, XDH 2.76763
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, CHRM3, EGFR, TEK 2.40244
[CC] GO:0016020 membrane ABCB1, ACHE, ADORA1, ADORA3, ALOX15, ALOX5, ALPL, AR, AXL, CA12, CA14, CA2, CA4, CA9, CACNA1C, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ESR1, F10, FLT3, FUT7, GLO1, GPR35, HCAR2, HSD11B1, HSD17B2, HSD17B3, IGF1R, INSR, KDR, KIT, MAOA, MET, MMP2, NISCH, NR3C2, PGR, PHF8, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, PTPRS, SMAD3, SRC, TEK, TNKS, TNKS2, TYR 2.20433
[CC] GO:0005886 plasma membrane ABCB1, ACHE, ADORA1, ADORA3, ALOX15, ALPL, AR, AXL, CA12, CA14, CA2, CA4, CA9, CACNA1C, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, EGFR, ESR1, F10, FLT3, GLO1, GPR35, HCAR2, IGF1R, INSR, KDR, KIT, MET, MMP2, NISCH, PIK3CA, PIK3CB, PIM1, PTPN1, PTPRS, SMAD3, SRC, TEK 2.15516
[CC] GO:0005654 None AKR1B1, ALOX5, APEX1, AR, AURKB, CDC25B, CDK6, CSNK2A1, DUSP3, DYRK1A, DYRK2, DYRK3, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, MIF, NQO2, NR3C1, NR3C2, NUAK1, PGR, PHF8, PIM1, PPARA, RORC, SMAD3, SRC, TNKS, TOP2A 2.01874
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, AOX1, AR, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DYRK2, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, PGR, PHF8, PIM1, PPARA, PTPN1, RORC, SMAD3, TNKS, TYR, XDH 21.0308
[MF] GO:0003824 catalytic activity ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CDK6, CHRM1, CHRM3, CHRM5, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, F10, FLT3, FUT7, GLO1, HASPIN, HSD11B1, HSD17B1, HSD17B2, HSD17B3, HSPA1A, IGF1R, INSR, KDR, KIT, MAOA, MET, MIF, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PHF8, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, PTPRS, SRC, TEK, TNKS, TNKS2, TOP2A, TUBB3, TYR, XDH 19.8397
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX15, ALOX5, ALPL, AOX1, APEX1, AR, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CDK6, CHRM3, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, GLO1, HASPIN, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NISCH, NQO2, NR3C1, NR3C2, NUAK1, PGR, PHF8, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TUBB3, TYR, XDH 18.9042
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 15.7217
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, PGR, PHF8, PPARA, PTPN1, RORC, SMAD3, TNKS 12.3082
[MF] GO:0004713 protein tyrosine kinase activity AXL, CLK1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, SRC, TEK 10.0749
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CDK6, CHRM1, CHRM2, CHRM3, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, SRC, TEK, TOP2A 10.0749
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, AOX1, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD11B1, HSD17B1, HSD17B2, HSD17B3, MAOA, NQO2, PHF8, PTGS1, PTGS2, TYR, XDH 9.98925
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, AOX1, APEX1, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CHRM3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DYRK2, DYRK3, ESR1, ESR2, ESRRA, ESRRB, F10, GLO1, KIT, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, NUAK1, PGR, PHF8, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, TNKS, TNKS2, TOP2A, TYR, XDH 9.82198
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 9.65883
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 9.5691
[MF] GO:0003707 steroid hormone receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, RORC 9.28089
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, AOX1, APEX1, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DYRK2, DYRK3, ESR1, ESR2, ESRRA, ESRRB, F10, GLO1, KIT, MMP1, MMP12, MMP2, MMP9, NQO2, NR3C1, NR3C2, NUAK1, PGR, PHF8, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, TNKS, TNKS2, TOP2A, TYR, XDH 9.14056
[MF] GO:0005496 steroid binding AR, ESR1, ESR2, ESRRA, ESRRB, HSD17B1, NR3C1, NR3C2, PGR, RORC, SHBG 9.09042
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIM1, SRC, TEK 8.58809
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 8.00958
[MF] GO:0042562 hormone binding ACHE, AR, CHRM3, EGFR, HSD17B1, IGF1R, INSR, NQO2, NR3C1, SHBG 7.87872
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, TEK 7.76795
[MF] GO:0016301 kinase activity AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 7.37092
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding AR, ESR1, ESR2, ESRRA, ESRRB, PGR, PPARA, RORC 7.2072
[MF] GO:0004879 nuclear receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, PGR, PPARA, RORC 7.2072
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, GLO1 7.05987
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, TEK 6.9464
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PHF8, PTGS1, PTGS2, TYR 6.71928
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PHF8, XDH 6.58353
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AR, AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, KIT, MET, NR3C1, NR3C2, PGR, PPARA, RORC, TEK 6.26591
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 6.15888
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AKR1C3, AOX1, CBR1, HSD11B1, HSD17B1, HSD17B2, HSD17B3, XDH 6.13906
[MF] GO:0016907 None CHRM1, CHRM2, CHRM3, CHRM5 6.04167
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.01302
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AR, AXL, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, KIT, MET, NR3C1, NR3C2, PGR, PPARA, RORC, TEK 5.57604
[MF] GO:0008289 lipid binding ALOX15, AR, AXL, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, HSD17B1, NISCH, NR3C1, NR3C2, PGR, PPARA, RORC, SHBG 5.46655
[MF] GO:0043168 anion binding ABCB1, ALOX15, AOX1, AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, F10, FABP3, FABP4, FLT3, HASPIN, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NISCH, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PTPRS, SRC, TEK, TOP2A, TUBB3, XDH 5.31767
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AR, AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, KIT, MET, NR3C1, NR3C2, PGR, PPARA, RORC, TEK 5.28467
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2, SRC 5.28258
[MF] GO:0005524 ATP binding ABCB1, AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A 5.14958
[MF] GO:0004497 monooxygenase activity AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 5.14129
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AR, AXL, CHRM1, CHRM2, CHRM3, CHRM5, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, KIT, MET, NR3C1, NR3C2, PGR, PPARA, RORC, SMAD3, TEK 5.04446
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2, SRC 5.04149
[MF] GO:0036094 small molecule binding ABCB1, ADORA1, AOX1, AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FABP3, FABP4, FLT3, HASPIN, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A, TUBB3, XDH 4.99228
[MF] GO:0032559 adenyl ribonucleotide binding ABCB1, AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A 4.9694
[MF] GO:0030554 adenyl nucleotide binding ABCB1, AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A 4.91885
[MF] GO:0000166 nucleotide binding ABCB1, AOX1, AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A, TUBB3, XDH 4.87376
[MF] GO:1901265 nucleoside phosphate binding ABCB1, AOX1, AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A, TUBB3, XDH 4.87223
[MF] GO:0004712 protein serine/threonine/tyrosine kinase activity AURKB, CLK1, DYRK1A, DYRK1B, DYRK2, DYRK3 4.85207
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR, KIT 4.8345
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 4.73148
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, AKR1C3, CBR1, HSD11B1, HSD17B1, HSD17B2, HSD17B3 4.457
[MF] GO:0043560 insulin receptor substrate binding IGF1R, INSR, PIK3CA, PIK3CB 4.45277
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1C3, HSD11B1, HSD17B1, HSD17B2, HSD17B3 4.39656
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CDC25B, CDK6, CLK1, CSNK2A1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, F10, FLT3, HASPIN, IGF1R, INSR, KDR, KIT, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PHF8, PIK3CA, PIM1, PTPN1, PTPRS, SRC, TEK 4.33437
[MF] GO:0016229 steroid dehydrogenase activity AKR1C3, HSD11B1, HSD17B1, HSD17B2, HSD17B3 4.25697
[MF] GO:0035639 purine ribonucleoside triphosphate binding ABCB1, AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A, TUBB3 4.10106
[MF] GO:0004674 protein serine/threonine kinase activity AURKB, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, HASPIN, NUAK1, PIK3CA, PIM1 3.96034
[MF] GO:0032555 purine ribonucleotide binding ABCB1, AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A, TUBB3 3.91647
[MF] GO:0017076 purine nucleotide binding ABCB1, AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A, TUBB3 3.86684
[MF] GO:0032553 ribonucleotide binding ABCB1, AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, TOP2A, TUBB3 3.85573
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, NQO2, PTGS1, PTGS2, SRC, XDH 3.68486
[MF] GO:0097367 carbohydrate derivative binding ABCB1, ADORA1, AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSPA1A, IGF1R, INSR, KDR, KIT, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PTPRS, SRC, TEK, TOP2A, TUBB3 3.64768
[MF] GO:0015464 None CHRM1, CHRM2, CHRM3, CHRM5 3.60462
[MF] GO:0047035 testosterone dehydrogenase (NAD+) activity AKR1C3, HSD17B2, HSD17B3 3.5012
[MF] GO:0016903 None AKR1B1, AKR1B10, AKR1C3, AOX1, XDH 3.41972
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 3.38491
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, APEX1, CSNK2A1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, NISCH, PIM1, PPARA, PTPN1, SMAD3, SRC 3.3443
[MF] GO:0032403 protein complex binding ACHE, ADORA1, APEX1, EGFR, ESRRB, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, NISCH, PPARA, PTPN1, SMAD3, SRC 3.33775
[MF] GO:0097159 organic cyclic compound binding ABCB1, ADORA1, AOX1, APEX1, AR, AURKB, AXL, CDK6, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HASPIN, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, NQO2, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SHBG, SMAD3, SRC, TEK, TOP2A, TUBB3, XDH 3.24753
[MF] GO:1901363 heterocyclic compound binding ABCB1, ADORA1, AOX1, APEX1, AR, AURKB, AXL, CDK6, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HASPIN, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MET, MMP12, NQO2, NR3C1, NR3C2, NUAK1, PGR, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TUBB3, XDH 3.07425
[MF] GO:0004629 None ADORA1, CHRM1, CHRM3, CHRM5 2.82922
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 2.73583
[MF] GO:0042578 None ADORA1, ALPL, APEX1, CDC25B, CHRM1, CHRM3, CHRM5, DUSP3, PTPN1, PTPRS 2.7128
[MF] GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity EGFR, KIT, MET, PIK3CA, PIK3CB 2.69917
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.69672
[MF] GO:0045550 None AKR1B10, AKR1C3 2.69672
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.69672
[MF] GO:0008389 None CYP2A13, CYP2A6 2.69672
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6 2.65692
[MF] GO:0052813 phosphatidylinositol bisphosphate kinase activity EGFR, KIT, MET, PIK3CA, PIK3CB 2.62956
[MF] GO:0042802 identical protein binding ACHE, AOX1, CSNK2A1, DYRK1A, EGFR, ESR1, ESR2, FLT3, IGF1R, KDR, KIT, MET, MIF, MMP9, NISCH, NQO2, PGR, PTGS2, SMAD3, TOP2A, TYR, XDH 2.5627
[MF] GO:0035004 phosphatidylinositol 3-kinase activity EGFR, KIT, MET, PIK3CA, PIK3CB 2.50282
[MF] GO:0099528 None CHRM1, CHRM2, CHRM3, CHRM5 2.49205
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.30619
[MF] GO:0047718 None AKR1B10, AKR1C3 2.30619
[MF] GO:0047045 None AKR1C3, HSD17B3 2.30619
[MF] GO:0051213 dioxygenase activity ALOX15, ALOX5, PHF8, PTGS1, PTGS2 2.17957
[MF] GO:0008081 None ADORA1, APEX1, CHRM1, CHRM3, CHRM5 2.15795
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.06158
[MF] GO:0005497 None AR, SHBG 2.06158
[MF] GO:0016788 None ACHE, ADORA1, ALPL, APEX1, CA1, CA2, CDC25B, CHRM1, CHRM3, CHRM5, DUSP3, PTPN1, PTPRS 2.02265


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 16.5384
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, AKR1C3, CYP1B1, PTGS2, CYP19A1, IGF1R 11.1774
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, HSD17B2, CYP1A2, CYP1A1, HSD17B3, AKR1C3, CYP1B1, CYP19A1 9.0267
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1, EGFR, ESR2, HSPA1A 7.0162
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, FLT3, MMP1, MMP2, PIK3CB, PTGS2, MMP9, EGFR, IGF1R, AR, CDK6, PIK3CA, KIT, MET 6.4293
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 6.8058
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, INSR, ADORA1, PIK3CB, PTGS2, PTGS1 6.4293
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, EGFR, IGF1R 5.7525
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, CHRM3, CHRM1, PIK3CA, CHRM5, CACNA1C, PIK3CB 5.7491
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, PTGS2 6.5256
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CDK6, CHRM1, PIK3CA, INSR, KIT, KDR, TEK, PIK3CB, MET, EGFR, IGF1R 5.5737
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, SRC, INSR, KIT, KDR, TEK, PIK3CB, MET, EGFR, IGF1R 5.6749
Metabolic pathways_Homo sapiens_hsa01100 CBR1, MAOA, ALOX15, HSD17B3, AKR1C3, AKR1B1, PTGS2, TYR, CYP19A1, PTGS1, HSD11B1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 5.4578
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 5.7525
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, AKR1C3, PTGS2, PTGS1 5.0194
Ras signaling pathway_Homo sapiens_hsa04014 PIK3CA, INSR, KIT, KDR, TEK, PIK3CB, MET, EGFR, IGF1R 4.6356
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, KIT, PIK3CB, MET, EGFR 4.8486
Melanoma_Homo sapiens_hsa05218 CDK6, PIK3CA, PIK3CB, MET, EGFR, IGF1R 4.7476
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, ABCB1, PIK3CA, PIM1, CYP1B1, PTGS2, MMP9, MET, EGFR, CDC25B 4.5844
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, CHRM1, PIK3CA, ADORA1, CACNA1C, PIK3CB, PPARA 4.1526
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM3, CHRM1, PIK3CA, SRC, CHRM5, PIK3CB, EGFR 3.9772
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, INSR, TEK, PIK3CB, EGFR, IGF1R 3.9772
Tryptophan metabolism_Homo sapiens_hsa00380 MAOA, CYP1A2, CYP1A1, AOX1, CYP1B1 4.7438
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, KIT, PIM1, PIK3CB 4.0717
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 4.7113
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, SRC, KDR, PIK3CB, PTGS2 3.9772
Glioma_Homo sapiens_hsa05214 CDK6, PIK3CA, PIK3CB, EGFR, IGF1R 3.8729
Serotonergic synapse_Homo sapiens_hsa04726 MAOA, ALOX5, ALOX15, CACNA1C, PTGS2, PTGS1 3.8348
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KIT, KDR, MET, EGFR, IGF1R, HSPA1A 3.5148
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, INSR, PIK3CB, IGF1R, HSPA1A 3.8908
Pancreatic cancer_Homo sapiens_hsa05212 CDK6, SMAD3, PIK3CA, PIK3CB, EGFR 3.8551
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, SRC, KDR, PIK3CB, MET, EGFR, IGF1R 3.3793
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, CHRM3, CHRM1, GPR35, ADORA3, CHRM5, ADORA1, NR3C1 3.347
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1, ESR2 3.7124
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, PIK3CA, INSR, PIK3CB, EGFR, IGF1R 3.4802
Hepatitis B_Homo sapiens_hsa05161 CDK6, SMAD3, PIK3CA, SRC, PIK3CB, MMP9 3.3125
Prostate cancer_Homo sapiens_hsa05215 AR, PIK3CA, PIK3CB, EGFR, IGF1R 3.3428
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, SRC, CACNA1C, PIK3CB, PTGS2, EGFR 3.1455
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, PIK3CA, MMP2, PIM1, PIK3CB 3.1358
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PGR, PIK3CB, CDC25B, IGF1R 3.1771
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, INSR, ADORA1, CACNA1C, PIK3CB 3.0443
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, CHRM3, CHRM1, CHRM5, CACNA1C, EGFR 2.8877
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, INSR, PIK3CB, PPARA 3.0097
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1, PIK3CA, PIK3CB, HSPA1A 2.6209
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PIK3CA, INSR, KIT, PIK3CB, EGFR 2.5328
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, PIK3CA, ESRRB, PIK3CB, IGF1R 2.5522
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6, SMAD3, PIK3CA, PIK3CB 2.7133
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6, PIK3CA, PIK3CB, EGFR 3.0933
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.1282
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, CACNA1C, EGFR 2.4088
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PIK3CA, INSR, PIK3CB, NR3C2 3.5923
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, SRC, PIK3CB, EGFR 2.474
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, INSR, PIK3CB, IGF1R 2.3639
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, INSR, CACNA1C, PIK3CB 3.3125
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, SRC, PIK3CB, ESR1 2.0387
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, PIK3CA, PIK3CB, PTGS2 2.4852
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 2.6209
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, MAOA, CYP1A2, AOX1 2.7981
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, PIK3CB, HSPA1A 2.0387
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, PIK3CB, PTGS1 2.0064
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.0387
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1 2.8801
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, ADORA3, ADORA1, PIK3CB 2.0257
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, INSR, PIK3CB, IGF1R 1.9876
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 2.7981
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, INSR, PIK3CB, PPARA 1.7291
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA, EGFR 1.8983
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, CACNA1C, EGFR, CDC25B, HSPA1A 1.6236
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, PIM1, AOX1, PIK3CB 1.6672
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PIK3CA, INSR, PIK3CB 1.8425
Tyrosine metabolism_Homo sapiens_hsa00350 MAOA, AOX1, MIF, TYR 3.7552
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET, EGFR 1.5766
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.5156
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, PIK3CB, HSPA1A 1.3737
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, PIK3CA, SRC, PIK3CB 1.3577
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2097
Purine metabolism_Homo sapiens_hsa00230 XDH 0.216
Tuberculosis_Homo sapiens_hsa05152 SRC 0.216
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSPA1A 0.2242
Alcoholism_Homo sapiens_hsa05034 MAOA 0.216
Alzheimer's disease_Homo sapiens_hsa05010 CACNA1C 0.2242
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.2453
Phagosome_Homo sapiens_hsa04145 TUBB3 0.2453
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.2812
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, CACNA1C, PIK3CB 1.1195
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, PIK3CB 1.5156
Axon guidance_Homo sapiens_hsa04360 MET 0.295
Oocyte meiosis_Homo sapiens_hsa04114 AR, PGR, IGF1R 1.2957
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB, EGFR 1.4908
Vascular smooth muscle contraction_Homo sapiens_hsa04270 CACNA1C 0.3102
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3, PIK3CA, PIK3CB 1.4619
Glutamatergic synapse_Homo sapiens_hsa04724 CACNA1C 0.3239
Influenza A_Homo sapiens_hsa05164 PIK3CA, PIK3CB, HSPA1A 0.9801
Cell cycle_Homo sapiens_hsa04110 CDK6, SMAD3, CDC25B 1.2912
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, SRC, PIK3CB 0.9278
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.3608
Gap junction_Homo sapiens_hsa04540 SRC, TUBB3, EGFR 1.6203
HTLV-I infection_Homo sapiens_hsa05166 SMAD3, PIK3CA, PIK3CB 0.6972
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.3787
Circadian entrainment_Homo sapiens_hsa04713 CACNA1C 0.3787
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.6714
Apoptosis_Homo sapiens_hsa04210 PIK3CA, PIK3CB 0.6696
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.3882
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 0.6849
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.6661
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, PIK3CB 0.7371
Salivary secretion_Homo sapiens_hsa04970 CHRM3 0.3905
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 0.6972
Dopaminergic synapse_Homo sapiens_hsa04728 MAOA, CACNA1C 0.7009
Dilated cardiomyopathy_Homo sapiens_hsa05414 CACNA1C 0.3893
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 1.9076
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.3905
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.4053
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 0.8153
Peroxisome_Homo sapiens_hsa04146 XDH 0.4067
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB, EGFR 2.1353
Melanogenesis_Homo sapiens_hsa04916 KIT, TYR 0.8471
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 0.8256
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 CACNA1C 0.4099
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB 0.8471
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PIK3CB 0.8861
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 0.8548
Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 CACNA1C 0.4067
Cardiac muscle contraction_Homo sapiens_hsa04260 CACNA1C 0.4177
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CACNA1C, PTGS2 0.8435
Pancreatic secretion_Homo sapiens_hsa04972 CHRM3, CA2 0.8661
Complement and coagulation cascades_Homo sapiens_hsa04610 F10 0.416
Taste transduction_Homo sapiens_hsa04742 CHRM3, CACNA1C 0.9404
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.4196
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 1.8834
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.4331
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 0.9031
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, PTGS2 0.8861
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 0.9158
Colorectal cancer_Homo sapiens_hsa05210 SMAD3, PIK3CA, PIK3CB 1.978
GABAergic synapse_Homo sapiens_hsa04727 SRC, CACNA1C 0.9158
Insulin secretion_Homo sapiens_hsa04911 CHRM3, CACNA1C 0.9303
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.4454
Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 CACNA1C 0.431
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.4477
Long-term potentiation_Homo sapiens_hsa04720 CACNA1C 0.461
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.0264
Shigellosis_Homo sapiens_hsa05131 SRC 0.4638
Gastric acid secretion_Homo sapiens_hsa04971 CHRM3, CA2 1.02
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 1.0688
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.0437
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.4904
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2 1.0437
Amphetamine addiction_Homo sapiens_hsa05031 MAOA, CACNA1C 1.0762
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.1454
Renin secretion_Homo sapiens_hsa04924 ADORA1, CACNA1C 1.1034
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.0956
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 TUBB3 0.52
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.1542
Legionellosis_Homo sapiens_hsa05134 CLK1, HSPA1A 1.2055
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOA 0.5532
Malaria_Homo sapiens_hsa05144 MET 0.558
Cocaine addiction_Homo sapiens_hsa05030 MAOA 0.558
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.5651
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.56
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.5875
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.344
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.3309
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOA 0.6216
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.6216
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.6661
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.6972
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.7335
Base excision repair_Homo sapiens_hsa03410 APEX1 0.679
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.6236
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.708
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 1.6411
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.5802
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7385
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.5028
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7009
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7335
Histidine metabolism_Homo sapiens_hsa00340 MAOA 0.7678
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.8207
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOA, MIF 2.0261
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 4.8486
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.9352
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.2308


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)