TCM Prescription: Xin Yi Powder



Prescription Description
Prescription IDTCMF2825
Pinyin NameXin Yi San
Chinese Name辛夷散
English NameXin Yi Powder
Function Description治肺虚, 风寒湿热之气加之, 鼻内壅塞, 涕出不已, 或气息不通, 或不闻香臭
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with IndicationLung, Nose
ReferenceSATCM
Reference Book/linkhttp://www.satcm.gov.cn/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH670 Ligusticum sinense 藁本 TCMH670 ITSAP3226-14
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH1531 Akebia quinata 木通 TCMH1531 ITSAJ4440-14
TCMH562 Saposhnikovia divaricata 防风 TCMH562 ITSAE3225-14
TCMH1665 Notopterygium incisum 羌活 TCMH1665 JF755946
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
TCMH118 Angelica dahurica 白芷 TCMH118 ITSAK3312-14
TCMH2320 Magnolia liliflora 辛夷仁 TCMH2320 GBVT919-13, GBVT884-13
TCMH2239 Asarum sieboldii 细辛 TCMH2239 ITSAI1576-14
TCMH1906 Cimicifuga foetida 升麻 TCMH1906
Reference: SATCM

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT220 CYP2J2 Cytochrome P450 2J2 Oxidoreductase P51589
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT407 MYLK Myosin light chain kinase, smooth muscle Kinase Q15746
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT594 PTAFR Platelet activating factor receptor GPCR P25105
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT675 ADRB1 Beta-1 adrenergic receptor GPCR P08588
TCMT689 TGM2 Protein-glutamine gamma-glutamyltransferase Transferase P21980
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT704 ERBB2 Receptor protein-tyrosine kinase erbB-2 Kinase P04626
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT725 CACNA1C Voltage-gated L-type calcium channel alpha-1C subunit Ion channel Q13936
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT778 KCNA5 Voltage-gated potassium channel subunit Kv1.5 Ion channel P22460
TCMT780 CACNA1D Voltage-gated L-type calcium channel alpha-1D subunit Ion channel Q01668
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1183 Candida albicans SC5314
TCMT1186 Plasmodium yoelii yoelii
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1282 Colletotrichum orbiculare
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ERBB2, ESR1, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MET, PPARA 11.1944
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 9.98506
[BP] GO:0008152 metabolic process ACHE, ADORA1, ADRB1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTAFR, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 9.92499
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 9.89981
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APP, AXL, BCL2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FABP3, HSD11B2, HSD17B2, IGF1R, MMP2, MMP9, PPARA, PTAFR, SRC, TYR 9.22564
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, PTAFR, SRC, TYR 9.0513
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, APP, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, IGF1R, KDR, MMP2, PPARA, PTAFR, SRC, TYR 8.55882
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ERBB2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, IGF1R, MMP2, PPARA, PTAFR, SRC 7.73565
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRB1, AKR1B1, APP, AURKB, AXL, BCL2, CA12, CA2, CA7, CACNA1C, CDK6, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, F3, FABP3, FABP4, FLT3, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KDR, MET, PPARA, PTAFR, SRC, TNKS, TNKS2, XDH 7.63966
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FUT7, GBA2, PIM1, PPARA, PTAFR, TYR, XDH 7.57602
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ERBB2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, PPARA, SRC, TYR 7.27582
[BP] GO:0042221 response to chemical AKR1B1, ALPL, APP, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, IGF1R, KDR, MMP2, MMP9, PPARA, PTAFR, SRC, TYR 7.24702
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, F3, FABP3, FLT3, IGF1R, KDR, MMP2, MMP9, PIM1, PTAFR, SRC, XDH 7.24702
[BP] GO:0014070 response to organic cyclic compound ALPL, APP, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRA, FLT3, HSD11B2, PTAFR, SRC, TYR 7.15554
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.0555
[BP] GO:0032502 developmental process ACHE, ADORA1, ADRB1, AKR1B1, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CACNA1C, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD17B2, KDR, MET, MMP2, MMP9, PIM1, PPARA, SRC, TNKS2, TYR 6.89511
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, PPARA, PTAFR, SRC 6.83868
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 6.54578
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRB1, AKR1B1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, F3, FLT3, KDR, MET, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 6.49698
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GBA2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, PIM1, PPARA, PTAFR, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 6.49698
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRB1, AKR1B1, APP, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, F3, FLT3, KDR, MET, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 6.49591
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRB1, AKR1B1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTAFR, PTPN1, SRC, TNKS, TNKS2, XDH 6.46532
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 6.01034
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APP, BCL2, CACNA1C, CDK6, CYP19A1, CYP1B1, EGFR, ERBB2, F3, IGF1R, KDR, MET, MMP9, PTAFR, SRC 6.01034
[BP] GO:0010035 response to inorganic substance AKR1B1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, MMP9, SRC 5.96649
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APP, BCL2, CDK6, CYP19A1, CYP1B1, EGFR, ERBB2, F3, IGF1R, KDR, MET, MMP9, PTAFR, SRC 5.66836
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, APP, AXL, BCL2, CA2, CACNA1C, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, KDR, MMP9, PIM1, PPARA, SRC, TYR 5.6077
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ERBB2, FABP3, FABP4, FUT7, GBA2, MET, PPARA 5.59742
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRB1, AKR1B1, APP, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTAFR, PTPN1, SRC, TNKS, TNKS2, XDH 5.58242
[BP] GO:0032501 multicellular organismal process ADORA1, ADRB1, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AXL, BCL2, CACNA1C, CYP19A1, CYP1A2, CYP1B1, EGFR, ESR1, ESRRB, F3, FABP4, HSD11B2, HSD17B2, IGF1R, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTAFR, SRC, TNKS2, TYR 5.57867
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.57867
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CACNA1C, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.57867
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 5.41777
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, EGFR, ERBB2, ESR1, F3, FLT3, IGF1R, KDR, MMP2, MMP9, PIM1, PTAFR 5.34654
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, PIM1, SRC 5.33739
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APP, BCL2, CDK6, CYP19A1, CYP1B1, EGFR, ERBB2, F3, IGF1R, KDR, MET, MMP9, PTAFR, SRC 5.33155
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TYR, XDH 5.3058
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APP, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, PTAFR, SRC 5.23938
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRB1, AKR1B1, APP, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ERBB2, ESRRA, F3, FABP4, FLT3, KDR, MET, MMP2, MMP9, PTAFR, PTPN1, SRC, TNKS, TNKS2, XDH 5.23024
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTAFR, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 5.18078
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRB1, AKR1B1, APP, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ERBB2, F3, FLT3, KDR, MET, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 5.12697
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APP, AXL, BCL2, CDK6, CYP1A1, CYP1B1, EGFR, ERBB2, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, PTAFR, SRC 5.09575
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIM1, SRC, TNKS 5.09575
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CACNA1C, CDK6, EGFR, KDR, SRC, TNKS, TNKS2 5.0517
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.88166
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRB1, AKR1B1, APP, AXL, BCL2, CYP1B1, EGFR, ERBB2, F3, FLT3, KDR, MET, PTPN1, SRC, XDH 4.86443
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.78914
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRB1, AKR1B1, APP, AURKB, AXL, BCL2, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, ESR1, ESR2, F3, FLT3, IGF1R, KDR, MET, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 4.67282
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SRC, XDH 4.61985
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRB1, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ERBB2, ESR1, F3, FLT3, IGF1R, KDR, MET, MMP9, PTPN1, SRC, XDH 4.59616
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRB1, AKR1B1, APP, AURKB, AXL, BCL2, CA2, CA7, CACNA1C, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, ESR1, ESR2, F3, FLT3, IGF1R, KDR, MET, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 4.57407
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APP, BCL2, CYP19A1, CYP1B1, EGFR, F3, IGF1R, KDR, MET, MMP9, PTAFR, SRC 4.52009
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SRC, XDH 4.44229
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.44229
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, SRC 4.44229
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, SRC 4.39473
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SRC 4.26493
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRB1, APP, BCL2, CDC25B, EGFR, ERBB2, ESRRB, FABP3, FLT3, KDR, MMP9, PTAFR, PTPN1, SRC, XDH 4.23512
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRB1, APP, BCL2, CDC25B, EGFR, ERBB2, ESRRB, FABP3, FLT3, KDR, MMP9, PTAFR, PTPN1, SRC, XDH 4.23512
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRB1, APP, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, MET, MMP9, PPARA, PTAFR, PTPN1, SRC, TNKS, TNKS2, XDH 4.16352
[BP] GO:0048583 regulation of response to stimulus ADORA1, ADRB1, AKR1B1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, ESR1, ESR2, ESRRA, F3, FABP4, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PPARA, PTAFR, PTPN1, SRC, TNKS, TNKS2, XDH 4.15454
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIM1, PTAFR, PTPN1, SRC, TNKS, XDH 4.12899
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, F3, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, IGF1R, KDR, MMP2, MMP9, PPARA, PTAFR, PTPN1, SRC, TYR 4.05885
[BP] GO:0009628 response to abiotic stimulus ADORA1, ADRB1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, EGFR, HSD11B2, MMP2, PPARA, PTAFR, SRC, TYR 4.02785
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIM1, SRC, TNKS 4.02279
[BP] GO:0042493 response to drug AKR1B1, AXL, BCL2, CA9, CDK6, CYP1A1, CYP1B1, EGFR, FABP3, HSD11B2, KDR, PTAFR, SRC 4.01545
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 4.01545
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SRC 4.01544
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, EGFR, FLT3, HSD11B2, PTAFR, SRC 4.00031
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FUT7, GBA2, MMP1, MMP2, MMP9, SRC, XDH 3.98138
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRB1, APP, AURKB, BCL2, CDC25B, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, IGF1R, KDR, MET, MMP9, PPARA, PTAFR, PTPN1, SRC, TNKS, TNKS2, XDH 3.92234
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC, XDH 3.91515
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APP, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, PTAFR, PTPN1, SRC 3.91246
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APP, AXL, BCL2, CA2, CA7, CACNA1C, CDK6, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, F3, IGF1R, KDR, MET, MMP9, PPARA, PTAFR, PTPN1, SRC 3.91246
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, EGFR, FLT3, HSD11B2, PTAFR, SRC 3.91246
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIM1, PTAFR, PTPN1, SRC, TNKS, XDH 3.89094
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 3.88996
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, GBA2, PTAFR, TYR 3.88628
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRB1, APP, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, IGF1R, KDR, MET, MMP9, PPARA, PTAFR, PTPN1, SRC, TNKS, TNKS2, XDH 3.88628
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, EGFR, ESR1, ESRRB, HSD11B2, HSD17B2, MMP2, MMP9, PTAFR, SRC 3.88202
[BP] GO:0042592 homeostatic process ADORA1, ADRB1, AKR1B1, APP, AXL, BCL2, CA12, CA2, CA7, CACNA1C, EGFR, ESR1, FABP3, FABP4, FLT3, MET, SRC 3.86824
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 3.82262
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CYP1A1, EGFR, ERBB2, ESR1, FLT3, MET, PIM1, SRC, TYR 3.80703
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.75519
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 3.75519
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRB1, APP, BCL2, CDC25B, EGFR, ERBB2, ESRRB, FABP3, FABP4, FLT3, IGF1R, KDR, MMP9, PPARA, PTAFR, PTPN1, SRC, XDH 3.75473
[BP] GO:0044093 positive regulation of molecular function ADORA1, ADRB1, APP, AURKB, BCL2, CDC25B, EGFR, ERBB2, ESR1, ESR2, F3, FLT3, MET, MMP9, PTAFR, PTPN1, SRC, TNKS, XDH 3.732
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.71712
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.71712
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRB1, APP, BCL2, CDC25B, EGFR, ERBB2, ESRRB, FABP3, FABP4, FLT3, IGF1R, KDR, MMP9, PPARA, PTAFR, PTPN1, SRC, XDH 3.71673
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, EGFR, F3, IGF1R, KDR, MET, MMP9, PTAFR, SRC 3.69186
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 3.68815
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, EGFR, MMP9, SRC 3.66367
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, SRC 3.6505
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, BCL2, CA1, CSNK2A1, EGFR, ERBB2, F3, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTAFR, PTPN1, SRC, TNKS, TNKS2 3.61276
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APP, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, PTAFR, SRC 3.60152
[BP] GO:0009611 response to wounding ACHE, ADORA3, BCL2, CYP1A1, EGFR, ERBB2, PPARA 3.60108
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, EGFR, F3, IGF1R, KDR, MET, MMP9, PTAFR, SRC 3.58724
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRB1, AKR1B1, APP, AXL, BCL2, CA1, CA2, CACNA1C, CDK6, CSNK2A1, CYP1B1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIM1, PPARA, PTAFR, PTPN1, SRC, TNKS, TNKS2 3.58291
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, EGFR, F3, IGF1R, KDR, MET, MMP9, PTAFR, SRC 3.48947
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, GBA2 3.48947
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, EGFR, IGF1R, KDR, MMP9, PIM1, PTPN1, SRC 3.47403
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, APP, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, MET, MMP9, PPARA, PTAFR, PTPN1, SRC, TNKS, TNKS2, XDH 3.44593
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TNKS 3.41955
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRB1, APP, AXL, BCL2, CA2, CACNA1C, CDK6, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, ESRRB, F3, KDR, MET, MMP9, PIM1, PTAFR, SRC, TNKS2, XDH 3.40738
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, EGFR, F3, IGF1R, KDR, MET, MMP9, PTAFR, SRC 3.38483
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CDK6, CYP1B1, EGFR, KDR, PTAFR, SRC 3.37762
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.37762
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 3.30173
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, EGFR, ERBB2, ESR1, F3, FLT3, FUT7, GBA2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 3.29814
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AXL, CDK6, CYP1B1, EGFR, ESR1, IGF1R, MMP2, MMP9, PTAFR, SRC 3.29566
[BP] GO:2001225 regulation of chloride transport CA2, CA7, PTAFR 3.29491
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.29491
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, ADRB1, APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, EGFR, ERBB2, ESR1, ESR2, F3, FABP4, FLT3, IGF1R, MET, MMP9, PIM1, PPARA, PTAFR, PTPN1, SRC, TNKS, XDH 3.29304
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC 3.28424
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRB1, APP, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, ERBB2, ESR1, F3, FABP4, FLT3, IGF1R, MMP9, PTAFR, PTPN1, SRC, TNKS, XDH 3.27155
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, EGFR, FABP3, FLT3, HSD11B2, IGF1R, MMP2, PPARA, PTAFR, SRC, TYR 3.27155
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA 3.25921
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, CACNA1C, KDR, SRC 3.25921
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, PTAFR 3.25255
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, ERBB2, F3, MET, SRC, XDH 3.22363
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, EGFR, FLT3, HSD11B2, PTAFR 3.17543
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2, XDH 3.16396
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, ADRB1, APP, AURKB, BCL2, CDC25B, EGFR, ERBB2, ESR1, F3, FLT3, PTAFR, PTPN1, SRC, TNKS, XDH 3.10636
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 3.09812
[BP] GO:0010038 response to metal ion APP, BCL2, CA2, CYP1A1, CYP1A2, EGFR, FABP4, MMP9 3.04637
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 3.02432
[BP] GO:0009891 positive regulation of biosynthetic process ADRB1, APP, AURKB, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, KDR, MET, PPARA, PTAFR, SRC, TNKS, TNKS2 3.02432
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, PTAFR, SRC 3.02432
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, ERBB2, F3, MET, SRC 2.98103
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.98103
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, EGFR, FABP3, FLT3, HSD11B2, IGF1R, MMP2, PPARA, PTAFR, SRC, TYR 2.98103
[BP] GO:0048869 cellular developmental process ACHE, ADRB1, ALPL, APP, AXL, BCL2, CDC25B, CDK6, CYP1A1, EGFR, ERBB2, ESR1, ESRRB, FABP4, FLT3, FUT7, GBA2, KDR, MET, MMP2, MMP9, SRC 2.9539
[BP] GO:0045776 None ADORA1, ADRB1, PPARA, PTAFR 2.94826
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 2.9442
[BP] GO:0009115 None AOX1, XDH 2.93352
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRB1, AKR1B1, APP, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, ERBB2, ESR1, ESR2, F3, FLT3, IGF1R, KDR, MET, MMP9, PTPN1, SRC, TNKS, TNKS2, XDH 2.93352
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, APP, BCL2, CDC25B, EGFR, ERBB2, ESRRB, FLT3, KDR, MMP9, PTPN1, SRC, XDH 2.90909
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.9069
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, AXL, BCL2, CYP1B1, EGFR, MMP9, SRC 2.86807
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, MET, MMP9, PPARA, SRC, TNKS 2.86807
[BP] GO:0042325 regulation of phosphorylation ADORA1, APP, BCL2, CDC25B, EGFR, ERBB2, ESRRB, FABP4, FLT3, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 2.85583
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, APP, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2, XDH 2.83916
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, SRC 2.79671
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, KDR, SRC 2.79286
[BP] GO:1901184 None ADORA1, APP, EGFR, ERBB2, MMP9 2.77864
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 2.7596
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.75096
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, SRC, TNKS 2.74956
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, BCL2, CDC25B, CYP19A1, EGFR, ESR1, ESRRB, HSD17B2, SRC 2.74246
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, SRC 2.74146
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR 2.72859
[BP] GO:0032787 None ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, PPARA 2.71475
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.68045
[BP] GO:1901654 None AKR1B1, CA9, CSNK2A1, EGFR, PTAFR, SRC 2.66699
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, SRC 2.66699
[BP] GO:0010676 None ESRRB, PPARA, PTAFR, SRC 2.64465
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.64045
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.62503
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.61983
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.61879
[BP] GO:0031328 positive regulation of cellular biosynthetic process ADRB1, APP, AURKB, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, FABP3, IGF1R, MET, PPARA, PTAFR, SRC, TNKS, TNKS2 2.60193
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.55318
[BP] GO:0002009 morphogenesis of an epithelium BCL2, CA2, CA9, EGFR, ESR1, MET, SRC 2.53853
[BP] GO:0046110 None AOX1, XDH 2.53853
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.53853
[BP] GO:0001503 ossification ALPL, BCL2, EGFR, MMP2, MMP9 2.53176
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, APP, EGFR, ERBB2, FLT3, KDR, PTPN1, SRC, XDH 2.53051
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, APP, BCL2, CDC25B, CSNK2A1, EGFR, ERBB2, ESR1, F3, FLT3, KDR, MMP9, PTAFR, PTPN1, SRC, XDH 2.52949
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, EGFR, ESR1, PPARA, SRC 2.52949
[BP] GO:0035588 None ADORA1, ADORA3, PTAFR 2.50115
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 2.49717
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, BCL2, CA12, CA2, CA7, CACNA1C, EGFR, ESR1, FABP3, FABP4, MET 2.49171
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, APP, BCL2, CDC25B, EGFR, ERBB2, FLT3, KDR, MMP9, PTPN1, SRC, XDH 2.48652
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, SRC 2.47917
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TNKS, TNKS2 2.47713
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1B1, KDR, SRC 2.46839
[BP] GO:0080134 regulation of response to stress ADORA1, APP, CDK6, CYP19A1, EGFR, ESR1, F3, FABP4, IGF1R, MET, MMP2, PPARA, PTPN1, SRC, XDH 2.4642
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.4537
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, EGFR 2.44979
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, EGFR 2.44128
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process APP, AURKB, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, IGF1R, KDR, MET, PPARA, PTAFR, SRC, TNKS, TNKS2 2.42486
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.40028
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, BCL2, CDK6, CYP19A1, EGFR, ERBB2, ESR1, ESR2, IGF1R, MET, MMP9, PPARA, PTPN1, SRC, XDH 2.39343
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.38085
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.35563
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 2.35563
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.34944
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APP, EGFR, ERBB2, ESR1, FLT3, IGF1R, MMP2, PTAFR, SRC 2.34754
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, PTAFR 2.34047
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 2.31378
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, EGFR, IGF1R, SRC, TNKS, TNKS2 2.31253
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.30223
[BP] GO:0070213 None TNKS, TNKS2 2.30223
[BP] GO:0006145 None AOX1, XDH 2.30223
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.30223
[BP] GO:0040014 regulation of multicellular organism growth ADRB1, APP, BCL2, TNKS2 2.29781
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CYP1A1, EGFR, HSD11B2, SRC, TYR 2.28691
[BP] GO:0051130 positive regulation of cellular component organization APP, AURKB, AXL, BCL2, ESR1, IGF1R, KDR, MET, MMP1, MMP9, SRC, TNKS, TNKS2 2.28226
[BP] GO:0045913 None ESRRB, PPARA, PTAFR, SRC 2.27755
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, APP, BCL2, CDC25B, EGFR, ERBB2, ESR1, F3, FLT3, KDR, MMP9, PTAFR, PTPN1, SRC, XDH 2.27602
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process ADRB1, APP, AURKB, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, IGF1R, MET, PPARA, PTPN1, SRC, TNKS, TNKS2 2.27528
[BP] GO:0051240 positive regulation of multicellular organismal process ADRB1, APP, AXL, BCL2, CA2, CYP1B1, EGFR, ESRRB, F3, KDR, MET, MMP9, PIM1, PTAFR, SRC 2.26965
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, CDC25B, EGFR, ERBB2, FABP4, FLT3, IGF1R, PTPN1, SRC, TNKS 2.25242
[BP] GO:0031099 regeneration AXL, BCL2, CSNK2A1, EGFR, FLT3 2.24547
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, PIM1, PPARA, TYR 2.24401
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.22267
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AOX1, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FUT7, GBA2, XDH 2.21711
[BP] GO:0043408 regulation of MAPK cascade ADORA1, APP, EGFR, ERBB2, FLT3, IGF1R, KDR, PTPN1, SRC, XDH 2.20509
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, EGFR, TNKS, TNKS2 2.20504
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, APP, BCL2, CDC25B, EGFR, ERBB2, FABP4, FLT3, IGF1R, KDR, MMP9, PTPN1, SRC, XDH 2.1914
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.18207
[BP] GO:0050730 None ADORA1, APP, EGFR, FLT3, PTPN1, SRC 2.15902
[BP] GO:0032845 None ADORA1, BCL2, SRC, TNKS, TNKS2 2.14388
[BP] GO:0035587 None ADORA1, ADORA3, PTAFR 2.13854
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, ADRB1, AKR1B1, APP, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, HSD11B2, MMP2, MMP9, PPARA, PTAFR, PTPN1, SRC 2.13163
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, EGFR, ERBB2, FLT3, IGF1R, PTPN1, SRC 2.13163
[BP] GO:0031100 animal organ regeneration AXL, CSNK2A1, EGFR, FLT3 2.12787
[BP] GO:0043696 None CDK6, ESRRB 2.12787
[BP] GO:0043697 None CDK6, ESRRB 2.12787
[BP] GO:0010641 None F3, SRC 2.12787
[BP] GO:0071248 cellular response to metal ion CYP1A1, CYP1A2, EGFR, FABP4, MMP9 2.10162
[BP] GO:0008217 None ADORA1, ADRB1, HSD11B2, PPARA, PTAFR 2.08936
[BP] GO:0032204 None AURKB, SRC, TNKS, TNKS2 2.08877
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, HSD11B2, IGF1R, PPARA, SRC 2.07483
[BP] GO:0035265 organ growth BCL2, CYP19A1, ESR1 2.06716
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR 2.06716
[BP] GO:0019538 protein metabolic process ACHE, ALPL, APP, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, EGFR, ERBB2, ESR1, F3, FLT3, FUT7, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, TNKS, TNKS2 2.04635
[BP] GO:0048729 tissue morphogenesis BCL2, CA2, CA9, EGFR, ESR1, MET, SRC 2.0364
[BP] GO:0050793 regulation of developmental process ADRB1, APP, AXL, BCL2, CA2, CDK6, CYP1B1, EGFR, ERBB2, ESR1, ESRRA, ESRRB, F3, KDR, PIM1, PPARA, SRC, TNKS2, XDH 2.03574
[BP] GO:0071396 cellular response to lipid AXL, CDK6, EGFR, ESR1, FLT3, PTAFR, SRC 2.03426
[BP] GO:0071276 cellular response to cadmium ion CYP1A2, EGFR, MMP9 2.03426
[BP] GO:0003018 None ADORA1, ADRB1, EGFR, PTAFR, SRC 2.02655
[BP] GO:0044070 regulation of anion transport ADORA1, CA2, CA7, PTAFR 2.02348
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, TYR 2.02348
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRB1, APP, AURKB, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTAFR, PTPN1, SRC, TNKS, TNKS2, XDH 2.01519
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, ADRB1, AKR1B1, AKR1B10, ALOX5, AOX1, APP, AURKB, BCL2, CA1, CA2, CA4, CA7, CACNA1C, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ERBB2, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KDR, MMP2, MMP9, PIM1, PTAFR, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 3.47891
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ADRB1, ALOX5, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ERBB2, ESR1, F3, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B2, IGF1R, KDR, MET, MMP2, PIM1, PTAFR, PTPN1, SRC, TNKS, TNKS2, TYR 3.43253
[CC] GO:0044432 endoplasmic reticulum part APP, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, FLT3, GBA2, HSD11B1, HSD11B2, HSD17B2, PTPN1 2.97601
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, GBA2, HSD11B1, HSD11B2, HSD17B2 2.585
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, ERBB2 2.57842
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ADRB1, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ERBB2, ESR1, F3, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B2, IGF1R, KDR, MET, PTAFR, PTPN1, SRC, TYR 2.47917
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ADRB1, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CACNA1C, CSNK2A1, EGFR, ERBB2, ESR1, F3, FLT3, GBA2, IGF1R, KDR, MET, MMP2, PIM1, PTAFR, PTPN1, SRC 2.1911
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, APP, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, TNKS, TYR, XDH 14.4653
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, AOX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTAFR, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 10.2753
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, EGFR, ERBB2, F3, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, PTPN1, SRC, TNKS, TNKS2, TYR, XDH 10.2197
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.2197
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.77687
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.49591
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD11B1, HSD11B2, HSD17B1, HSD17B2, TYR, XDH 6.33938
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET 6.16467
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, XDH 5.9487
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, PPARA, PTPN1, TNKS 5.74706
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.66365
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET 5.57867
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, TNKS, TNKS2, TYR, XDH 5.41777
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 5.4018
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 5.33739
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 5.12697
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, TNKS, TNKS2, TYR, XDH 5.11957
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, SRC 4.51528
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, SRC 4.34911
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, SRC 4.15454
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD11B2, HSD17B1, SRC, XDH 4.12083
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 4.11747
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1 4.11747
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA 3.98138
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.98138
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 3.91246
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRB1, AXL, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, MET, PPARA, PTAFR 3.81872
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIM1, SRC 3.81009
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIM1, PPARA, SRC 3.78898
[MF] GO:0008289 lipid binding AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, HSD11B2, HSD17B1, PPARA, PTAFR 3.69186
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA 3.68485
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRB1, AXL, CDK6, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, MET, PPARA, PTAFR 3.6381
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.60108
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 3.53195
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.48947
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.48947
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, ERBB2, KDR 3.41955
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6 3.2682
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRB1, AXL, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, MET, PPARA, PTAFR 3.25921
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIM1, SRC 3.1582
[MF] GO:0019899 enzyme binding ADRB1, APP, AURKB, BCL2, CDC25B, CYP1A1, CYP1A2, CYP2A6, EGFR, ERBB2, ESR1, ESR2, ESRRB, F3, MET, PPARA, PTAFR, PTPN1, SRC, TNKS2 3.05028
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.93352
[MF] GO:0003845 None HSD11B1, HSD11B2 2.93352
[MF] GO:0008389 None CYP2A13, CYP2A6 2.93352
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, EGFR, ESRRB, FLT3, IGF1R, KDR, MMP9, PIM1, PPARA, PTPN1, SRC 2.91613
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.89025
[MF] GO:0019902 phosphatase binding BCL2, EGFR, ERBB2, MET, PPARA, PTPN1 2.83886
[MF] GO:0016301 kinase activity AURKB, AXL, CDK6, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.83886
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRB1, AXL, EGFR, ERBB2, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, MET, PPARA, PTAFR 2.78394
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.62503
[MF] GO:0042802 identical protein binding ACHE, AOX1, APP, BCL2, CSNK2A1, EGFR, ERBB2, ESR1, ESR2, FLT3, IGF1R, KDR, MET, MMP9, TYR, XDH 2.50961
[MF] GO:0032403 protein complex binding ACHE, ADORA1, EGFR, ESRRB, FLT3, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC 2.49121
[MF] GO:0019903 protein phosphatase binding BCL2, EGFR, ERBB2, MET, PTPN1 2.47917
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.30223
[MF] GO:0035586 None ADORA1, ADORA3, PTAFR 2.26721
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CDK6, CSNK2A1, EGFR, ERBB2, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.26721
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.12787
[MF] GO:0036094 small molecule binding ADORA1, AOX1, AURKB, AXL, CDK6, CSNK2A1, EGFR, ERBB2, FABP3, FABP4, FLT3, HSD11B2, HSD17B1, IGF1R, KDR, MET, PIM1, SRC, XDH 2.06
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.03426


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.3042
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 9.2209
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 8.1045
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, ERBB2, MMP9, EGFR 7.0954
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, ERBB2, KDR, MMP9, MET, ESR1, EGFR, IGF1R 6.5743
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, ERBB2, MET, EGFR, IGF1R 7.0954
Pathways in cancer_Homo sapiens_hsa05200 CDK6, FLT3, MMP1, MMP2, ERBB2, BCL2, MMP9, MET, EGFR, IGF1R 5.3676
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 5.7049
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, ERBB2, BCL2, PIM1, CYP1B1, MMP9, MET, EGFR, CDC25B 5.38
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, TYR, GBA2, CYP19A1, HSD11B1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 5.1465
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, EGFR, ESR2 5.1473
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 5.4589
Focal adhesion_Homo sapiens_hsa04510 SRC, ERBB2, KDR, BCL2, MET, EGFR, IGF1R 4.54
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 4.1752
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, ADRB1, MET, EGFR, IGF1R 2.9851
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, ERBB2, MET, EGFR 3.3327
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1 3.3582
Melanoma_Homo sapiens_hsa05218 CDK6, MET, EGFR, IGF1R 3.2819
Prostate cancer_Homo sapiens_hsa05215 ERBB2, BCL2, EGFR, IGF1R 2.9431
Calcium signaling pathway_Homo sapiens_hsa04020 PTAFR, ERBB2, ADRB1, CACNA1C, EGFR 2.8356
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, PIM1, F3 2.7894
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, CACNA1C, EGFR 2.9259
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.3072
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CDK6, KDR, BCL2, MET, EGFR, IGF1R 2.4765
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, MET, EGFR, IGF1R 2.5714
HIF-1 signaling pathway_Homo sapiens_hsa04066 ERBB2, BCL2, EGFR, IGF1R 2.7747
Hepatitis B_Homo sapiens_hsa05161 CDK6, SRC, BCL2, MMP9 2.3102
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6, ERBB2, EGFR 2.4564
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1, ADRB1, CACNA1C 2.1585
Glioma_Homo sapiens_hsa05214 CDK6, EGFR, IGF1R 2.3102
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1, ADRB1 2.4564
Pancreatic cancer_Homo sapiens_hsa05212 CDK6, ERBB2, EGFR 2.3043
Renin secretion_Homo sapiens_hsa04924 ADORA1, ADRB1, CACNA1C 2.3102
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.0626
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 2.2326
cAMP signaling pathway_Homo sapiens_hsa04024 ADORA1, ADRB1, CACNA1C, PPARA 1.9378
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.2796
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, ERBB2, EGFR 2.0427
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2, AOX1 2.2738
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, EGFR, IGF1R 1.7916
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, BCL2, CACNA1C 1.7956
Gap junction_Homo sapiens_hsa04540 SRC, ADRB1, EGFR 2.0393
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5, CACNA1C 1.7943
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.5943
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 ADORA3, PTAFR, ADORA1, ADRB1 1.5369
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.7474
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2, ADRB1, CACNA1C 1.5315
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, AOX1 1.4786
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, CACNA1C, EGFR 1.4786
MAPK signaling pathway_Homo sapiens_hsa04010 CACNA1C, EGFR, CDC25B 1.0243
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.0871
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 1.0225
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.9788
Dilated cardiomyopathy_Homo sapiens_hsa05414 ADRB1, CACNA1C 1.1416
GABAergic synapse_Homo sapiens_hsa04727 SRC, CACNA1C 1.1528
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2 1.1644
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.9788
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2 0.9788
FoxO signaling pathway_Homo sapiens_hsa04068 EGFR, IGF1R 0.9101
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1 0.8989
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 1.1221
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.9101
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB, IGF1R 0.8771
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 0.9523
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8881
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.236
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.6708
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, SRC 0.6651
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.7515
Alzheimer's disease_Homo sapiens_hsa05010 APP, CACNA1C 0.7886
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, EGFR 0.6613
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.4225
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.4638
Endometrial cancer_Homo sapiens_hsa05213 ERBB2, EGFR 1.5171
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3604
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3739
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.3844
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3598
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.4195
Apoptosis_Homo sapiens_hsa04210 BCL2 0.4368
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.4427
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.4368
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.4349
Phospholipase D signaling pathway_Homo sapiens_hsa04072 EGFR 0.433
Platelet activation_Homo sapiens_hsa04611 SRC 0.4675
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.4699
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.4675
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4675
Axon guidance_Homo sapiens_hsa04360 MET 0.4621
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.492
Dopaminergic synapse_Homo sapiens_hsa04728 CACNA1C 0.4595
Glutamatergic synapse_Homo sapiens_hsa04724 CACNA1C 0.4823
Vascular smooth muscle contraction_Homo sapiens_hsa04270 CACNA1C 0.4699
Melanogenesis_Homo sapiens_hsa04916 TYR 0.5203
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.5203
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5203
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.5233
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.5203
Circadian entrainment_Homo sapiens_hsa04713 CACNA1C 0.5233
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5233
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5291
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5227
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5306
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5299
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CACNA1C 0.5203
Taste transduction_Homo sapiens_hsa04742 CACNA1C 0.5427
Salivary secretion_Homo sapiens_hsa04970 ADRB1 0.5306
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5306
Insulin secretion_Homo sapiens_hsa04911 CACNA1C 0.5373
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 CACNA1C 0.5427
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6 0.5645
Peroxisome_Homo sapiens_hsa04146 XDH 0.5427
Cardiac muscle contraction_Homo sapiens_hsa04260 CACNA1C 0.5479
Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 CACNA1C 0.5427
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.5468
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5645
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5704
Long-term potentiation_Homo sapiens_hsa04720 CACNA1C 0.5814
Bile secretion_Homo sapiens_hsa04976 CA2 0.569
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5814
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.5943
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5814
Amphetamine addiction_Homo sapiens_hsa05031 CACNA1C 0.5795
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.572
Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 CACNA1C 0.5645
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5936
Shigellosis_Homo sapiens_hsa05131 SRC 0.5814
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.5892
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5 0.5892
Staphylococcus aureus infection_Homo sapiens_hsa05150 PTAFR 0.6167
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8755
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6498
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.6613
Malaria_Homo sapiens_hsa05144 MET 0.6613
Type II diabetes mellitus_Homo sapiens_hsa04930 CACNA1C 0.6613
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.6613
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.6613
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.7916
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.8303
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2 0.7167
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.38
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7765
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0626
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.8383
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7964
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.819
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.819
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8435
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8383
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.959
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0287
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.3443


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)