TCM Prescription: Gong Xue Ting Granules



Prescription Description
Prescription IDTCMF3280
Pinyin NameGong Xue Ting Ke Li
Chinese Name宫血停颗粒
English NameGong Xue Ting Granules
Function Description月经过多, 崩漏
IndicationsMenorrhagia disorder, Metrorrhagia disorder, Irregular menstruation
Disease ICD-11 Category SB90 [Menorrhagia disorder (TM1), 月经过多 (TM1) ];
SB93 [Metrorrhagia disorder (TM1), 崩漏 (TM1) ];
GA20.3 [Abnormal regularity of uterine bleeding, 子宫出血周期异常 ];
Human Tissues Associated with IndicationUterus
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH981 Astragalus membranaceus 黄芪 TCMH981 ITSAK2981-14
TCMH426 Codonopsis pilosula 党参 TCMH426 ITSAL4530-14
TCMH1634 Typha angustata 蒲黄 TCMH1634 GBVX1726-13
TCMH1321 Os draconis 龙骨 TCMH1321
TCMH1525 Crassostrea gigas 牡蛎 TCMH1525 BCMOL364-12
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH1597 Ligustrum lucidum 女贞子 TCMH1597 ITSAM2109-14
TCMH1503 Eclipta prostrata 墨旱莲 TCMH1503 ITSAP4516-14
TCMH1906 Cimicifuga foetida 升麻 TCMH1906
TCMH2473 Leonurus japonicus 益母草 TCMH2473 ITSAN1807-14
TCMH2618 Citrus aurantium 枳壳 TCMH2618 ITSAA1279-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT221 ABCB11 Bile salt export pump Transporter O95342
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT281 DPP4 Dipeptidyl peptidase IV Unclassified P27487
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT561 NT5E 5'-nucleotidase Hydrolase P21589
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT61 MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 Unclassified Q07820
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT636 POLA1 DNA polymerase alpha subunit Transferase P09884
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT718 TXN2 Thioredoxin, mitochondrial Unclassified Q99757
TCMT719 TXN Thioredoxin Unclassified P10599
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT907 FDPS Farnesyl diphosphate synthase Lyase P14324


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1178 Actinomyces viscosus
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1318 Human T-lymphotropic virus 1
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 12.5807
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.5456
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FDPS, FUT7, GLO1, PIM1, PPARA, TBXAS1, TYR, XDH 10.7584
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FABP4, FDPS, FUT7, HSD17B1, HSD17B2, MET, PPARA, TBXAS1 8.44843
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 8.37891
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APEX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTPN1, PTPRS, RORC, SRC, TBXAS1, TOP2A, TYR, XDH 7.1812
[BP] GO:0019369 arachidonic acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1 6.53675
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, APEX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, PIM1, POLA1, POLB, PPARA, PTPN1, PTPRS, RORC, SRC, TBXAS1, TOP2A, TYR, XDH 6.48731
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1 6.33229
[BP] GO:0006690 icosanoid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1 6.10764
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FABP4, FDPS, FUT7, MET, PPARA, TBXAS1 5.77675
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FDPS, HSD17B1, HSD17B2 5.60454
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 5.57875
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.50568
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, GLO1, HCAR2, IGF1R, KDR, MCL1, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TOP2A, XDH 5.48232
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, HSD17B2, TBXAS1, TYR, XDH 5.42839
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, GLO1, HCAR2, IGF1R, KDR, MCL1, MET, MMP9, PIM1, PTPN1, SRC, TOP2A, XDH 5.29863
[BP] GO:0006631 fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, TBXAS1 4.98278
[BP] GO:0001676 long-chain fatty acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1 4.95209
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1 4.95209
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, APEX1, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, HSD17B2, IGF1R, MMP2, MMP9, POLB, PPARA, RORC, SRC, TYR 4.95209
[BP] GO:0010033 response to organic substance AKR1B1, APEX1, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MCL1, MMP2, POLB, PPARA, RORC, SRC, TYR 4.83522
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, APEX1, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, GLO1, HCAR2, IGF1R, KDR, MCL1, MMP9, PIM1, PTPN1, SRC, TOP2A, XDH 4.6673
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, APEX1, AURKB, AXL, CA2, CA9, CBR1, CDC25B, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, FUT7, GLO1, HSD17B2, KDR, MCL1, MET, MMP2, MMP9, PIM1, POLB, PPARA, PTPRS, RORC, SRC, TOP2A, TYR 4.64141
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 4.50538
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, GLO1, IGF1R, KDR, MCL1, MET, MMP9, PIM1, PPARA, PTPN1, SRC 4.3421
[BP] GO:0010035 response to inorganic substance AKR1B1, APEX1, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, SRC 4.2835
[BP] GO:0032787 None ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GLO1, PPARA, TBXAS1 4.13529
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, GLO1, IGF1R, KDR, MCL1, MET, MMP9, PIM1, PTPN1, SRC 4.02919
[BP] GO:0042221 response to chemical AKR1B1, APEX1, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MCL1, MMP2, MMP9, POLB, PPARA, RORC, SRC, TYR 3.91671
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.49836
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.46776
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 3.46776
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, HCAR2, KDR, MCL1, MET, MMP12, MMP9, PTPN1, SRC, XDH 3.46776
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FUT7, MMP1, MMP12, MMP2, MMP9, SRC, XDH 3.46776
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.46776
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.46776
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, HCAR2, KDR, MCL1, MET, MMP12, MMP9, PTPN1, SRC, XDH 3.45842
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, APEX1, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, FABP3, FABP4, FLT3, HCAR2, HSD17B1, HSD17B2, KDR, MCL1, MET, POLA1, POLB, PPARA, SRC, XDH 3.41023
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, GLO1, IGF1R, KDR, MCL1, MMP9, PIM1, PTPN1, SRC 3.38108
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GLO1, PIM1, PPARA, TBXAS1, TYR 3.3706
[BP] GO:0033993 response to lipid AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, FABP3, FLT3, HSD17B2, RORC, SRC, TYR 3.3706
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FDPS, FLT3, HCAR2, PPARA, RORC, SRC 3.3706
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.35648
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, FLT3, HSD17B2, KDR, POLB, PPARA, PTPRS, SRC, TYR 3.29214
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.20873
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.0184
[BP] GO:0051716 cellular response to stimulus AKR1B1, APEX1, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, IGF1R, KDR, MCL1, MMP2, MMP9, POLA1, POLB, PTPN1, RORC, SRC, TOP2A 2.99063
[BP] GO:0043436 oxoacid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GLO1, PIM1, PPARA, TBXAS1, TYR 2.95886
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APEX1, AURKB, AXL, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTPN1, PTPRS, RORC, SRC, TBXAS1, TOP2A, TYR, XDH 2.91613
[BP] GO:0006082 organic acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GLO1, PIM1, PPARA, TBXAS1, TYR 2.8925
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, APEX1, AURKB, AXL, CA2, CA6, CA9, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MCL1, MMP12, MMP2, MMP9, POLA1, POLB, PPARA, PTPN1, RORC, SRC, TOP2A, TYR 2.8925
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.70278
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, APEX1, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, FABP3, FLT3, HCAR2, IGF1R, KDR, MCL1, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SRC, TOP2A, XDH 2.69123
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APEX1, AXL, CA12, CA2, CA7, FABP3, FABP4, FLT3, MCL1, MET, POLA1, POLB, SRC 2.65323
[BP] GO:0006286 base-excision repair, base-free sugar-phosphate removal APEX1, POLB 2.63363
[BP] GO:0014070 response to organic cyclic compound APEX1, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FLT3, RORC, SRC, TYR 2.63141
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, APEX1, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, HCAR2, HSD17B1, HSD17B2, IGF1R, KDR, MCL1, MET, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTPN1, PTPRS, RORC, SRC, TBXAS1, TOP2A, TYR, XDH 2.56523
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 2.4676
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.40346
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.38956
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, CDC25B, CSNK2A1, CYP1B1, FABP3, FLT3, IGF1R, KDR, MMP12, MMP2, MMP9, PIM1, SRC, XDH 2.38494
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, FDPS 2.38494
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APEX1, AURKB, AXL, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTPN1, PTPRS, RORC, SRC, TBXAS1, TOP2A, TYR, XDH 2.37525
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, SRC 2.37479
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HCAR2, HSD17B1, HSD17B2 2.35006
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.34661
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.31641
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, RORC 2.28391
[BP] GO:0009725 response to hormone AKR1B1, APEX1, CA2, CA9, CSNK2A1, CYP1A2, FABP3, FLT3, PPARA, SRC 2.27703
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, MMP9, SRC 2.2657
[BP] GO:0009636 response to toxic substance AKR1B1, APEX1, AXL, CYP1A1, CYP1B1, KDR, POLB, SRC 2.26269
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, AXL, CA2, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, HSD17B2, KDR, MCL1, MMP9, PIM1, POLB, PPARA, PTPRS, RORC, SRC, TYR 2.2622
[BP] GO:0098502 DNA dephosphorylation APEX1, POLB 2.2553
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.2553
[BP] GO:0009719 response to endogenous stimulus AKR1B1, APEX1, CA2, CA9, CSNK2A1, CYP1A2, FABP3, FLT3, IGF1R, MMP2, PPARA, SRC 2.21611
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR 2.21468
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1 2.17692
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.17692
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, APEX1, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, FABP3, FABP4, FLT3, HCAR2, IGF1R, KDR, MCL1, MET, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SRC, TOP2A, XDH 2.15997
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, FDPS 2.14934
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, FDPS, HSD17B1, HSD17B2 2.13661
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, APEX1, AURKB, AXL, CDC25B, CSNK2A1, FDPS, FLT3, IGF1R, KDR, MET, PIM1, POLB, PTPN1, PTPRS, SRC, XDH 2.09827
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.08704
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.08703
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.03369
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.01363
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.01363
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1 2.00325
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APEX1, AURKB, CA1, CA2, CA4, CA5A, CA5B, CA7, CBR1, CDC25B, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FABP4, FDPS, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, KDR, MCL1, MMP2, MMP9, PIM1, POLA1, PTPN1, PTPRS, SRC, TBXAS1, TOP2A, TYR, XDH 2.19049
[CC] GO:0097443 sorting endosome KDR, PTPN1 1.67215
[CC] GO:0099055 None ADORA1, PTPRS 1.41323
[CC] GO:0099699 None ADORA1, PTPRS 1.41323
[CC] GO:0099240 None ADORA1, PTPRS 1.41323
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 17.7703
[MF] GO:0046914 transition metal ion binding ALOX5, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, GLO1, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, TBXAS1, TYR, XDH 15.5158
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FDPS, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PTPN1, PTPRS, SRC, TBXAS1, TOP2A, TYR, XDH 13.8002
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, POLB 13.7063
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.5992
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, GLO1, POLB 10.7396
[MF] GO:0043167 ion binding ACHE, ALOX5, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FABP4, FDPS, FLT3, GLO1, HSD17B1, IGF1R, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTPN1, PTPRS, RORC, SRC, TBXAS1, TOP2A, TYR, XDH 10.5196
[MF] GO:0043169 cation binding ACHE, ALOX5, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FDPS, GLO1, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, TBXAS1, TOP2A, TYR, XDH 7.17127
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.76225
[MF] GO:0046872 metal ion binding ALOX5, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FDPS, GLO1, MMP1, MMP12, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTPN1, RORC, TBXAS1, TOP2A, TYR, XDH 6.76225
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, GLO1, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC 6.76225
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, HSD17B2, TBXAS1, TYR, XDH 6.51394
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1, TYR 6.38525
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1, XDH 6.00004
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, SRC, TBXAS1 5.48803
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 5.34723
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, SRC, TBXAS1 5.29863
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TBXAS1, TYR 4.95209
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD17B1, POLA1, SRC, TBXAS1, XDH 4.10842
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 3.99413
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.38108
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, FLT3, IGF1R, KDR, MET, PIM1, PPARA, SRC, TOP2A 3.25301
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6 3.00568
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, CBR1, HSD17B1, HSD17B2, XDH 2.99903
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.94101
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, APEX1, CSNK2A1, FLT3, IGF1R, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SRC 2.79729
[MF] GO:0008389 None CYP2A13, CYP2A6 2.63363
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.38526
[MF] GO:0032403 protein complex binding ACHE, ADORA1, APEX1, FLT3, IGF1R, KDR, MMP12, MMP9, PPARA, PTPN1, SRC 2.32688
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HSD17B1, HSD17B2 2.22397


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 19.3707
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 8.1903
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 6.1825
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 5.6981
Metabolic pathways_Homo sapiens_hsa01100 FDPS, CBR1, AKR1B1, TYR, CYP19A1, POLA1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, XDH 5.3079
Chemical carcinogenesis_Homo sapiens_hsa05204 CBR1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 5.4905
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.4477
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, IGF1R 3.4977
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.1005
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.2826
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, MMP9, MET, CDC25B, MCL1 2.7007
Pathways in cancer_Homo sapiens_hsa05200 FLT3, MMP1, MMP2, MMP9, MET, IGF1R 2.1258
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.7007
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, TBXAS1 2.1775
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1 2.1476
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, KDR, MET, MCL1, IGF1R 1.7775
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, ADORA1, PPARA 1.7775
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.8857
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, IGF1R 1.7775
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, MET, IGF1R 1.768
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9 1.7775
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.5391
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.3363
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 1.0649
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.3368
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.3363
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.3072
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.2435
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3215
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, PIM1 1.0031
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.232
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.2435
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.0649
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.0166
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE 0.9547
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.9547
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2 1.2435
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.167
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 0.9547
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, ADORA3, ADORA1 0.9259
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.4865
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.8726
Platelet activation_Homo sapiens_hsa04611 SRC, TBXAS1 0.9219
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.9259
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.768
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 0.9255
Hepatitis B_Homo sapiens_hsa05161 SRC, MMP9 0.8099
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.8365
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1, MCL1 0.7749
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.757
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6631
Purine metabolism_Homo sapiens_hsa00230 POLA1, XDH 0.7328
Viral carcinogenesis_Homo sapiens_hsa05203 POLB, SRC 0.6507
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7303
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, SRC 0.6271
Base excision repair_Homo sapiens_hsa03410 POLB, APEX1 1.721
HTLV-I infection_Homo sapiens_hsa05166 POLB, FDPS 0.5479
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.2795
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.4935
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1 0.3476
Prostate cancer_Homo sapiens_hsa05215 IGF1R 0.4935
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4935
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2 0.3741
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3689
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4697
Influenza A_Homo sapiens_hsa05164 FDPS 0.3759
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3741
Apoptosis_Homo sapiens_hsa04210 MCL1 0.436
Gap junction_Homo sapiens_hsa04540 SRC 0.4935
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.4897
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4878
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4935
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.4928
Measles_Homo sapiens_hsa05162 CSNK2A1 0.436
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.452
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.4935
HIF-1 signaling pathway_Homo sapiens_hsa04066 IGF1R 0.4851
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.4393
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5479
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.4185
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4878
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.436
AMPK signaling pathway_Homo sapiens_hsa04152 IGF1R 0.452
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.4572
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.4067
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3689
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 IGF1R 0.436
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4935
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.4393
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4935
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.436
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.5309
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.452
Serotonergic synapse_Homo sapiens_hsa04726 ALOX5 0.4675
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.4928
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4928
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5 0.4572
Axon guidance_Homo sapiens_hsa04360 MET 0.4476
Peroxisome_Homo sapiens_hsa04146 XDH 0.4935
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5258
Glioma_Homo sapiens_hsa05214 IGF1R 0.5479
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4928
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5479
Pyrimidine metabolism_Homo sapiens_hsa00240 POLA1 0.4824
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5479
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5309
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5478
Bile secretion_Homo sapiens_hsa04976 CA2 0.5309
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.5479
Shigellosis_Homo sapiens_hsa05131 SRC 0.5479
Malaria_Homo sapiens_hsa05144 MET 0.6173
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.6796
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.7206
DNA replication_Homo sapiens_hsa03030 POLA1 0.716
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.7615
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7565
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.783
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.757
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7755
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 FDPS 0.8365


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)