Component: Clematidis armandii caulis 川木通


Description of the Component

Component ID
TCMH287
Latin Name
Clematidis armandii caulis
English Name
Armand clematis stem
Chinese Pinyin Name
Chuan Mu Tong
中文名
川木通
TCM Properties
TCM Meridians
Therapeutic Class English
For promoting diuresis and penetrating dampness
Therapeutic Class Chinese
利水渗湿
Functions
remove heat and induce diuresis, stimulate menstrual discharge, and promote lactation
Toxicity
NA
Geo-authentic habitats (道地产区)
Sichuan Province,Chongqing
Reference
Chinese Pharmacopoeia (2015)
Barcode ID
Barcode Source

TCM Prescriptions with the Component

Prescription ID Prescription English Name Prescription Chinese Name
TCMF2993 Ba Zheng Recipe 八正合剂
TCMF229 Ba Zheng Recipe 八正合剂
TCMF3588 Bi Dou Yan Oral Liquid 鼻窦炎口服液
TCMF1131 Bi Dou Yan Oral Liquid 鼻窦炎口服液
TCMF1184 Bi Yuan Shu Capsule 鼻渊舒胶囊
TCMF3687 Bi Yuan Shu Oral Liquid 鼻渊舒口服液
TCMF1183 Bi Yuan Shu Oral Liquid 鼻渊舒口服液
TCMF3893 Er Tong Hui Chun Granules 儿童回春颗粒
TCMF3901 Er Tong Hui Chun Pills 儿童回春丸
TCMF783 Fu Fang Zhen Zhu An Chuang Tablet 复方珍珠暗疮片
TCMFx4728 Ju He Pills 橘核丸
TCMF6882 Kou Yan Capsules 口炎胶囊
TCMF6982 Kou Yan Granules 口炎颗粒
TCMF4135 Lian Hua Feng Tea 莲花峰茶
TCMF4275 Ling Yuan Wan Ying Tea 灵源万应茶
TCMFx5174 Qu Feng Shi Zhi Tong Powder 祛风湿止痛散
TCMF5164 San She Yao Wine 三蛇药酒
TCMFx957 Xiao Yu Kang Capsule 消瘀康胶囊
TCMFx64 Xiao Yu Kang Tablets 消瘀康片
TCMF6206 Yao Zhi Gui Ling Ointment 药制龟苓膏
TCMF6577 Yuan Ji Lin Gan He Tea 源吉林甘和茶

Targeted Human Proteins by the Ingredient of Component

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT171 PTPN6 Protein-tyrosine phosphatase 1C Hydrolase P29350
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT214 MGLL Monoglyceride lipase Unclassified Q99685
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT233 PTPN11 Protein-tyrosine phosphatase 2C Hydrolase Q06124
TCMT273 NR1H4 Bile acid receptor FXR Nuclear receptor Q96RI1
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT281 DPP4 Dipeptidyl peptidase IV Unclassified P27487
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT41 IDH1 Isocitrate dehydrogenase [NADP] cytoplasmic Oxidoreductase O75874
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT566 NOS2 Nitric oxide synthase, inducible Oxidoreductase P35228
TCMT598 TOP1 DNA topoisomerase I Isomerase P11387
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT64 PPARD Peroxisome proliferator-activated receptor delta Nuclear receptor Q03181
TCMT67 PPARG Peroxisome proliferator-activated receptor gamma Nuclear receptor P37231
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603


Targeted Pathogenic Microbes by the Ingredient of Component

Target ID Target Name
TCMT1104 Sortase
TCMT1107 Protease
TCMT1178 Actinomyces viscosus
TCMT1207 Legionella pneumophila
TCMT1218 Staphylococcus aureus
TCMT1229 Enterococcus faecalis
TCMT1248 Hepatitis C virus
TCMT1255 Human immunodeficiency virus 1
TCMT1294 Human parainfluenza virus 3
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1465 Entamoeba histolytica

Ingredient Structrues

Ingredient ID: TCMC995
Formula: C35H60O6

Ingredient ID: TCMC801
Formula: C29H50O

Ingredient ID: TCMC6661
Formula: C46H74O16

Ingredient ID: TCMC3966
Formula: C29H50O

Ingredient ID: TCMC3243
Formula: C30H48O4

Ingredient ID: TCMC3233
Formula: C35H60O6

Ingredient ID: TCMC3224
Formula: C28H58O

Ingredient ID: TCMC3065
Formula: C25H52

Ingredient ID: TCMC2667
Formula: C30H50O

Ingredient ID: TCMC2458
Formula: C35H58O6

Ingredient ID: TCMC2107
Formula: C29H48O

Ingredient ID: TCMC1830
Formula: C16H32O2

Ingredient ID: TCMC1786
Formula: C30H48O3

Ingredient ID: TCMC1192
Formula: C30H50O

Ingredient ID: TCMC1122
Formula: C28H44O

Properties

Ingredient ID Formulae Name MW AlogP MlogP XlogP # HBA # HBD PSA # Rotatable Bond # Ring # Heacy Atom Lipinski RO5 Violation
TCMC801 C29H50O Beta-Sitosterol 414.39 1.3 4.54 11.595 1 1 20.23 13 4 30 1
TCMC995 C35H60O6 Daucosterol 576.44 -0.4469 4.65 10.487 6 4 99.38 19 5 41 1
TCMC1122 C28H44O Ergosterol 396.34 2.2555 4.43 9.499 1 1 20.23 11 4 29 1
TCMC1192 C30H50O Friedeline 426.39 3.2175 4.65 12.613 1 0 17.07 8 5 31 1
TCMC1786 C30H48O3 Oleanolic_Acid 456.36 2.1298 4.43 9.052 3 2 57.53 10 5 33 1
TCMC1830 C16H32O2 Palmitic Acid 256.24 -3.8977 3 7.57 2 1 37.3 16 0 18 2
TCMC2107 C29H48O Stigmasterol 412.37 1.2566 4.54 11.071 1 1 20.23 12 4 30 1
TCMC2458 C35H58O6 Stigmasterol Glucoside 574.42 -0.4903 4.65 9.963 6 4 99.38 18 5 41 1
TCMC2667 C30H50O Beta-Amyrin 426.39 3.0116 4.65 11.546 1 1 20.23 9 5 31 1
TCMC3065 C25H52 Pentacosane 352.4069017 -6.5214 4.21 14.565 0 0 0 22 0 25 2
TCMC3224 C28H58O 1-Octacosanol,N-Octacosanol 410.4487665 -7.8854 4.43 14.507 1 1 20.23 26 0 29 2
TCMC3233 C35H60O6 Alexandrin,Daucosterol,Eleutheroside A 576.4389896 -0.4469 4.65 10.487 6 4 99.38 9 5 41 1
TCMC3243 C30H48O4 Hederagenin 471.347435 0.3613 4.32 7.868 4 2 80.59 2 5 34 1
TCMC3966 C29H50O Sitosterol,Β-Sitosterol 414.3861662 1.3 4.54 11.595 1 1 20.23 6 4 30 1
TCMC6661 C46H74O16 Clemontanoside A 881.4898613 -3.358 4.76 4.446 16 8 257.35 8 8 62 2

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1. General Information of the Component  
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3. Putative Targets  
4. Activity & References for Filtering Putative Targets  
5. Ingredient Data & Chemical Structure Information (Properties, InChI, InChIkey, SMILES, etc.)