Component: Coptis chinensis 川黄连


Description of the Component

Component ID
TCMH283
Latin Name
Coptis chinensis
English Name
rhizome of chinese goldthread
Chinese Pinyin Name
Chuan Huang Lian
中文名
川黄连
TCM Properties
Cold,Bitter
TCM Meridians
Large Intestine,Stomach,Small Intestine,Liver,Heart
Therapeutic Class English
Heat clearence
Therapeutic Class Chinese
清热
Functions
remove damp-heat, quench fire and counteract toxicity
Toxicity
NA
Geo-authentic habitats (道地产区)
NA
Reference
Chinese Pharmacopoeia (2015)
Barcode ID
ITSAO4469-14
Barcode Source
BOLDSYSTEMS

TCM Prescriptions with the Component

Prescription ID Prescription English Name Prescription Chinese Name
TCMF2628 Heart Tonification and Calming Cream 补心安神膏
TCMFx1906 Infant Fattening Pill 肥儿丸
TCMFx1289 Infant Fattening Pill 肥儿丸

Targeted Human Proteins by the Ingredient of Component

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT1 EHMT2 Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Transferase Q96KQ7
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT11 HIF1A Hypoxia-inducible factor 1 alpha Transcription factor Q16665
TCMT125 GBA Beta-glucocerebrosidase Hydrolase P04062
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT132 BCHE Butyrylcholinesterase Hydrolase P06276
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT143 CA3 Carbonic anhydrase III Lyase P07451
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT18 GAA Lysosomal alpha-glucosidase Hydrolase P10253
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT213 SLC22A1 Solute carrier family 22 member 1 Transporter O15245
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT248 CXCL8 Interleukin-8 Unclassified P10145
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT276 SLCO2B1 Solute carrier organic anion transporter family member 2B1 Transporter O94956
TCMT277 SLCO1B3 Solute carrier organic anion transporter family member 1B3 Transporter Q9NPD5
TCMT278 SLCO1B1 Solute carrier organic anion transporter family member 1B1 Transporter Q9Y6L6
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT281 DPP4 Dipeptidyl peptidase IV Unclassified P27487
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT307 KCNH2 HERG Ion channel Q12809
TCMT31 CYP2C19 Cytochrome P450 2C19 Oxidoreductase P33261
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT41 IDH1 Isocitrate dehydrogenase [NADP] cytoplasmic Oxidoreductase O75874
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT559 ADRB2 Beta-2 adrenergic receptor GPCR P07550
TCMT6 NFKB1 Nuclear factor NF-kappa-B p105 subunit Transcription factor P19838
TCMT615 SENP8 Sentrin-specific protease 8 Protease Q96LD8
TCMT69 THRB Thyroid hormone receptor beta-1 Nuclear receptor P10828
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT80 MAPK1 MAP kinase ERK2 Kinase P28482
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712


Targeted Pathogenic Microbes by the Ingredient of Component

Target ID Target Name
TCMT1104 Sortase
TCMT1109 Reverse transcriptase
TCMT1154 Sortase
TCMT1218 Staphylococcus aureus
TCMT1226 Klebsiella pneumoniae
TCMT1230 Human herpesvirus 5
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1246 Escherichia coli
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1289 Shigella dysenteriae
TCMT1305 Salmonella enteritidis
TCMT1318 Human T-lymphotropic virus 1
TCMT1346 Helicobacter pylori
TCMT1353 Plasmodium yoelii
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1385 Candida shehatae
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1454 Bacillus subtilis
TCMT1458 Filobasidiella neoformans
TCMT1460 Mycobacterium intracellulare
TCMT1462 Streptococcus mutans
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Ingredient Structrues

Ingredient ID: TCMC934
Formula: C20H19NO4

Ingredient ID: TCMC904
Formula: C5H14NO

Ingredient ID: TCMC897
Formula: C16H18O9

Ingredient ID: TCMC801
Formula: C29H50O

Ingredient ID: TCMC785
Formula: C20H18NO4.ClH

Ingredient ID: TCMC784
Formula: C20H18NO4

Ingredient ID: TCMC572
Formula: C21H21NO6

Ingredient ID: TCMC315
Formula: C21H25NO4

Ingredient ID: TCMC304
Formula: C10H18O

Ingredient ID: TCMC2811
Formula: C19H15NO4

Ingredient ID: TCMC2694
Formula: C20H24O6

Ingredient ID: TCMC2541
Formula: C10H18O

Ingredient ID: TCMC2506
Formula: C19H21NO4

Ingredient ID: TCMC2457
Formula: C20H22O6

Ingredient ID: TCMC2398
Formula: C20H17NO5

Ingredient ID: TCMC2383
Formula: C20H23NO4

Ingredient ID: TCMC2378
Formula: C19H15NO4.ClH

Ingredient ID: TCMC2253
Formula: C19H14NO4.ClH

Ingredient ID: TCMC2237
Formula: C16H12O5

Ingredient ID: TCMC2222
Formula: C8H8O4

Ingredient ID: TCMC2188
Formula: C17H14O7

Ingredient ID: TCMC2150
Formula: C21H25NO4

Ingredient ID: TCMC2013
Formula: C16H12O7

Ingredient ID: TCMC19
Formula: C20H22O6

Ingredient ID: TCMC1899
Formula: C20H22O6

Ingredient ID: TCMC1831
Formula: C21H22NO4

Ingredient ID: TCMC1828
Formula: C21H22NO4.ClH

Ingredient ID: TCMC1761
Formula: C10H9NO3

Ingredient ID: TCMC1636
Formula: C20H18NO4

Ingredient ID: TCMC1608
Formula: C10H16

Ingredient ID: TCMC1539
Formula: C21H24O7

Ingredient ID: TCMC1491
Formula: C26H30O8

Ingredient ID: TCMC1425
Formula: C20H19NO4.ClH

Ingredient ID: TCMC1424
Formula: C20H19NO4

Ingredient ID: TCMC1337
Formula: C21H21NO6

Ingredient ID: TCMC1173
Formula: C10H10O4

Ingredient ID: TCMC1159
Formula: C10H12O2

Ingredient ID: TCMC111
Formula: C21H21NO6

Ingredient ID: TCMC1047
Formula: C21H19NO4

Properties

Ingredient ID Formulae Name MW AlogP MlogP XlogP # HBA # HBD PSA # Rotatable Bond # Ring # Heacy Atom Lipinski RO5 Violation
TCMC19 C20H22O6 (-)-Pinoresinol 358.14 -2.0222 3 1.684 2 2 77.38 8 4 26 0
TCMC111 C21H21NO6 (3S)-6,7-Dimethoxy-3-(6-Methyl-7,8-Dihydro-5H-[1,3]Dioxolo[4,5-G]Isoquinolin-5-Yl)-3H-2-Benzofuran-1-One 383.14 -0.2155 3 2.577 3 0 66.46 6 5 28 0
TCMC304 C10H18O 2-(4-Methylcyclohex-3-En-1-Yl)Propan-2-Ol 154.14 1.1223 2.45 2.369 1 1 20.23 5 1 11 0
TCMC315 C21H25NO4 2,3,9,10-Tetramethoxy-6,8,13,13A-Tetrahydro-5H-Isoquinolino[2,1-B]Isoquinoline 355.18 0.0968 3.22 2.548 1 0 40.16 8 4 26 0
TCMC572 C21H21NO6 6,7-Dimethoxy-3-(6-Methyl-7,8-Dihydro-5H-[1,3]Dioxolo[4,5-G]Isoquinolin-5-Yl)-3H-2-Benzofuran-1-One 383.14 -0.2155 3 2.577 3 0 66.46 6 5 28 0
TCMC784 C20H18NO4 Berberine 336.12 -1.583 3.11 2.896 0 0 40.8 4 5 25 0
TCMC785 C20H18NO4.ClH Berberine Chloride 336.12 -1.583 3.11 2.896 0 0 40.8 4 5 25 0
TCMC801 C29H50O Beta-Sitosterol 414.39 1.3 4.54 11.595 1 1 20.23 13 4 30 1
TCMC897 C16H18O9 Chlorogenic Acid 354.1 -2.1962 2.23 -0.447 7 6 164.75 11 2 25 1
TCMC904 C5H14NO Choline 104.11 -1.5741 1.79 -0.837 1 1 20.23 6 0 7 0
TCMC934 C20H19NO4 Columbamine 338.14 -1.7924 3.11 2.45 0 1 51.8 7 4 25 0
TCMC1047 C21H19NO4 Dihydrochelerythrine 349.13 -0.2792 3.22 3.232 1 0 40.16 5 5 26 0
TCMC1159 C10H12O2 Eugenol 164.08 0.5166 2.34 2.484 0 1 29.46 5 1 12 0
TCMC1173 C10H10O4 Ferulic Acid 194.06 -0.3908 2.12 1.231 2 2 66.76 6 1 14 0
TCMC1337 C21H21NO6 Hydrastine 383.14 -0.2155 3 2.577 3 0 66.46 6 5 28 0
TCMC1424 C20H19NO4 Jatrorrhizine 338.14 -1.5606 3.11 1.039 2 1 49.2 6 4 25 0
TCMC1425 C20H19NO4.ClH Jatrorrhizine Chloride 337.13 -0.1035 3.11 1.92 3 0 48 6 4 25 0
TCMC1491 C26H30O8 Limonin 470.19 -0.4484 3.44 1.644 7 0 104.57 5 7 34 0
TCMC1539 C21H24O7 Medioresinol 388.15 -2.074 3 1.24 2 2 86.61 10 4 28 0
TCMC1608 C10H16 Myrcene 136.13 3.0936 2.56 4.17 0 0 0 6 0 10 0
TCMC1636 C20H18NO4 336.12 -1.583 3.11 2.896 0 0 40.8 4 5 25 0
TCMC1761 C10H9NO3 Noroxyhydrastinine 191.06 -0.3413 2.12 1.117 2 1 51.05 1 3 14 0
TCMC1828 C21H22NO4.ClH Palmatine Chloride 352.15 -1.3839 3.22 2.969 0 0 40.8 8 4 26 0
TCMC1831 C21H22NO4 Palmitine 352.15 -1.3839 3.22 2.969 0 0 40.8 8 4 26 0
TCMC1899 C20H22O6 Pinoresinol 358.14 -2.0222 3 1.684 2 2 77.38 8 4 26 0
TCMC2013 C16H12O7 Rhamnetin 316.06 -2.3927 2.45 1.9 2 4 116.45 7 3 23 0
TCMC2150 C21H25NO4 Tetrahydropalmatine 355.18 0.0968 3.22 2.548 1 0 40.16 8 4 26 0
TCMC2188 C17H14O7 Tricin 330.07 -1.9881 2.56 0.679 1 3 105.45 8 3 24 0
TCMC2222 C8H8O4 Vanillic Acid 168.04 -0.7519 1.9 0.626 2 2 66.76 5 1 12 0
TCMC2237 C16H12O5 Wogonin 284.07 -1.476 2.67 2.719 1 2 75.99 5 3 21 0
TCMC2253 C19H14NO4.ClH Coptisine Chloride 320.09 -1.7821 3 2.823 0 0 40.8 0 6 24 0
TCMC2378 C19H15NO4.ClH Thalifendine 321.1 -0.1514 3 2.164 3 0 48 2 5 24 0
TCMC2383 C20H23NO4 Magnoflorine 342.17 -1.9843 3.11 1.008 0 2 58.92 8 4 25 0
TCMC2398 C20H17NO5 Oxyberberine 351.11 -0.7529 3 2.385 2 0 57.23 4 5 26 0
TCMC2457 C20H22O6 (+/-)-Pinoresinol 358.14 -2.0222 3 1.684 2 2 77.38 8 4 26 0
TCMC2506 C19H21NO4 (+)-Norisocorydine 327.15 -0.7569 3 1.479 1 2 59.95 7 4 24 0
TCMC2541 C10H18O Alpha-Terpineol 154.14 1.1223 2.45 2.369 1 1 20.23 5 1 11 0
TCMC2694 C20H24O6 Isolariciresinol 360.16 -2.2141 3 1.061 2 4 99.38 11 3 26 0
TCMC2811 C19H15NO4 Thalidendine 322.11 -0.1281 3 2.096 2 1 30.93 2 5 24 0

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