Component: Siegesbeckiae herba 豨莶草


Description of the Component

Component ID
TCMH2238
Latin Name
Siegesbeckiae herba
English Name
NA
Chinese Pinyin Name
Xi Xian Cao
中文名
豨莶草
TCM Properties
TCM Meridians
Therapeutic Class English
Therapeutic Class Chinese
Functions
Toxicity
NA
Geo-authentic habitats (道地产区)
NA
Reference
Chinese Pharmacopoeia (2015)
Barcode ID
GQ434487
Barcode Source
GenBank

TCM Prescriptions with the Component

Prescription ID Prescription English Name Prescription Chinese Name
TCMFx3114 Ban Feng He Yao Wine 半枫荷药酒
TCMFx3330 Feng Shang Zhi Tong Ointment 风伤止痛膏
TCMFx3344 Feng Shi Bi Tong Yao Wine 风湿痹痛药酒
TCMF3462 Feng Shi Ning Yao Wine 风湿宁药酒
TCMFx3471 Feng Shi Tablets 风湿片
TCMFx3503 Feng Shi Xi Tong Tablets 风湿豨桐片
TCMFx3523 Feng Shi Yao Pills 风湿药丸
TCMF3548 Feng Shi Zhen Tong Pills 风湿镇痛丸
TCMFx3556 Feng Shi Zhi Tong Yao Wine 风湿止痛药酒
TCMF3598 Feng Tong Pills 风痛丸
TCMFx3150 Fu Fang Xia Tian Wu Tablets 复方夏天无片
TCMF3599 Gan Shen An Syrup 肝肾安糖浆
TCMF3669 Guan Jie Feng Tong Pills 关节风痛丸
TCMF6981 Gui Yuan Jin Gu Ning Shi Fu Ji 归元筋骨宁湿敷剂
TCMFx1109 Hua Mo Yan Capsule 滑膜炎胶囊
TCMFx4873 Hua Mo Yan Granules 滑膜炎颗粒
TCMFx1110 Hua Mo Yan Granules 滑膜炎颗粒
TCMFx94 Hua Mo Yan Tablets 滑膜炎片
TCMFx4317 Huo Luo Jian Shen Oral Liquid 活络健身液
TCMFx7099 Huo Luo Zhi Tong Pills 活络止痛丸
TCMFx4403 Jian Xin Tablets 健心片
TCMFx4069 Jin Qian Bai Hua She Yao Wine 金钱白花蛇药酒
TCMF4557 Jiu Zhi Xi Xian Cao Yao Wine 九制豨莶草药酒
TCMFx1193 She Xiang Kang Shuan Capsule 麝香抗栓胶囊
TCMFx5171 She Xiang Kang Shuan Pills 麝香抗栓丸
TCMF5200 Shou Wu Qiang Shen Tablets 首乌强身片
TCMFx5160 Sun Shang Zhi Tong Ointment 损伤止痛膏
TCMFx255 Tian Dan Tong Luo Capsule 天丹通络胶囊
TCMF254 Tian Dan Tong Luo Tablet 天丹通络片
TCMFx5535 Tian Qi Die Da Feng Shi Ruan Ointment 田七跌打风湿软膏
TCMFx5803 Xi Lian Feng Shi Pills 豨莶风湿丸
TCMFx5796 Xi Lian Feng Shi Tablets 豨莶风湿片
TCMFx5819 Xi Lian Oral Liquid 豨莶液
TCMFx5811 Xi Lian Tablets 豨莶片
TCMFx1161 Xi Tong Capsule 豨桐胶囊
TCMFx5782 Xi Tong Capsules 豨桐胶囊
TCMFx1160 Xi Tong Pills 豨桐丸
TCMFx5790 Xi Tong Pills 豨桐丸
TCMFx1159 Xi Xian Pills 豨莶丸
TCMFx149 Xi Xian Tong Shuan Capsule 豨莶通栓胶囊
TCMFx148 Xi Xian Tong Shuan Pills 豨莶通栓丸
TCMFx1158 Xi Hong Tong Luo Oral Liquid 豨红通络口服液
TCMFx384 Xin Shu Ning Tablet 心舒宁片
TCMFx5997 Xin Shu Ning Tablets 心舒宁片
TCMF6646 Yan Shou Tablets 延寿片
TCMFx6479 Yi Ling Jing 益龄精
TCMFx6532 Yi Nao Fu Jian Capsules 益脑复健胶囊
TCMF1068 Zhi Kang Tablet 痔康片
TCMF488 Zhuang Gu Shen Jin Capsule 壮骨伸筋胶囊
TCMFx6570 Zhuang Yao Xiao Tong Oral Liquid 壮腰消痛液

Targeted Human Proteins by the Ingredient of Component

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT143 CA3 Carbonic anhydrase III Lyase P07451
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT281 DPP4 Dipeptidyl peptidase IV Unclassified P27487
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT41 IDH1 Isocitrate dehydrogenase [NADP] cytoplasmic Oxidoreductase O75874
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372


Targeted Pathogenic Microbes by the Ingredient of Component

Target ID Target Name
TCMT1218 Staphylococcus aureus
TCMT1251 Candida albicans
TCMT1255 Human immunodeficiency virus 1
TCMT1294 Human parainfluenza virus 3
TCMT1438 Plasmodium falciparum
TCMT1463 Mycobacterium tuberculosis
TCMT1465 Entamoeba histolytica

Ingredient Structrues

Ingredient ID: TCMC801
Formula: C29H50O

Ingredient ID: TCMC7171
Formula: C20H32O4

Ingredient ID: TCMC7170
Formula: C20H34O3

Ingredient ID: TCMC7022
Formula: C21H24O8

Ingredient ID: TCMC6776
Formula: C26H40O6

Ingredient ID: TCMC6736
Formula: C26H44O8

Ingredient ID: TCMC6735
Formula: C28H46O9

Ingredient ID: TCMC6458
Formula: C21H26O8

Ingredient ID: TCMC6398
Formula: C26H44O8

Ingredient ID: TCMC6285
Formula: C20H34O4

Ingredient ID: TCMC6126
Formula: C15H24N2O3

Ingredient ID: TCMC5712
Formula: C20H32O4

Ingredient ID: TCMC5711
Formula: C20H32O4

Ingredient ID: TCMC5659
Formula: C20H32O4

Ingredient ID: TCMC5628
Formula: C28H46O9

Ingredient ID: TCMC4356
Formula: C21H20O11

Ingredient ID: TCMC4324
Formula: C29H48O

Ingredient ID: TCMC4212
Formula: C20H34O3

Ingredient ID: TCMC3827
Formula: C15H24

Ingredient ID: TCMC2459
Formula: C30H48O5

Ingredient ID: TCMC2111
Formula: C4H6O4

Ingredient ID: TCMC2107
Formula: C29H48O

Ingredient ID: TCMC1173
Formula: C10H10O4

Properties

Ingredient ID Formulae Name MW AlogP MlogP XlogP # HBA # HBD PSA # Rotatable Bond # Ring # Heacy Atom Lipinski RO5 Violation
TCMC801 C29H50O Beta-Sitosterol 414.39 1.3 4.54 11.595 1 1 20.23 13 4 30 1
TCMC1173 C10H10O4 Ferulic Acid 194.06 -0.3908 2.12 1.231 2 2 66.76 6 1 14 0
TCMC2107 C29H48O Stigmasterol 412.37 1.2566 4.54 11.071 1 1 20.23 12 4 30 1
TCMC2111 C4H6O4 Succinic Acid 118.03 -0.41 1.46 -0.71 4 2 74.6 5 0 8 0
TCMC2459 C30H48O5 Euscaphic Acid 488.35 0.822 4.21 5.966 5 4 97.99 12 5 35 1
TCMC3827 C15H24 Δ-Cadinol,Δ-Cadinene 204.1878008 2.2115 3.11 5.46 0 0 0 1 2 15 1
TCMC4212 C20H34O3 Darutigenol 322.2507949 0.4093 3.33 3.241 3 3 60.69 2 3 23 0
TCMC4324 C29H48O Stigmasterol 412.3705162 1.2566 4.54 11.071 1 1 20.23 5 4 30 1
TCMC4356 C21H20O11 Orientin 448.1005615 -4.2135 2.56 -1.483 6 8 188.14 3 4 32 1
TCMC5628 C28H46O9 Hythiemoside B 526.3141831 -0.9585 3.55 2.873 9 5 145.91 7 4 37 0
TCMC5659 C20H32O4 Ent-12Α,16-Epoxy-2Β,15Α,19-Trihydroxypimar-8(14)-Ene 336.2300595 -0.1376 3.22 1.464 4 3 69.92 1 4 24 0
TCMC5711 C20H32O4 Ent-12Α,16-Epoxy-2Β,15Α,19-Trihydroxypimar-8-Ene 336.2300595 0.0607 3.22 0.917 4 3 69.92 1 4 24 0
TCMC5712 C20H32O4 Ent-15-Oxo-2Β,16,19-Trihydroxypimar-8(14)-Ene 336.2300595 -0.2975 3.22 2.308 4 3 77.76 3 3 24 0
TCMC6126 C15H24N2O3 5Α,9Α-Dihydroxymatrine 281.1865177 -4.0247 2.56 -0.718 4 3 65.21 0 4 20 0
TCMC6285 C20H34O4 Kirenol 338.2457096 -0.331 3.22 1.898 4 4 80.92 3 3 24 0
TCMC6398 C26H44O8 Pubeside B 484.3036184 -1.8552 3.44 2.453 8 6 139.84 6 4 34 1
TCMC6458 C21H26O8 15-Hydroxy-9Α-Acetoxy-8Β-Isobutyryloxy-14-Oxo-Melampolide 406.1627678 0.7468 2.89 0.707 8 1 116.2 7 2 29 0
TCMC6735 C28H46O9 Hythiemoside A 526.3141831 -0.9585 3.55 2.873 9 5 145.91 7 4 37 0
TCMC6736 C26H44O8 Darutoside 484.3036184 -1.3376 3.44 2.133 8 6 139.84 5 4 34 1
TCMC6776 C26H40O6 Siegesetheric Acid I 447.274664 -0.3654 3.66 5.987 6 0 92.73 8 4 32 1
TCMC7022 C21H24O8 Orientalide 404.1471177 1.1664 2.89 0.634 8 1 116.2 7 2 29 0
TCMC7170 C20H34O3 Siegesbeckiol 322.2507949 0.1405 3.33 4.44 3 3 60.69 1 4 23 0
TCMC7171 C20H32O4 Siegesbeckic Acid 335.2222345 -1.848 3.22 3.961 4 2 80.59 3 4 24 0

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3. Putative Targets  
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