Component: Cortex lycii radicis 地骨皮


Description of the Component

Component ID
TCMH449
Latin Name
Cortex lycii radicis
English Name
root - bark of chinese wolfberry
Chinese Pinyin Name
Di Gu Pi
中文名
地骨皮
TCM Properties
Cold,Sweet
TCM Meridians
Lung,Kidney
Therapeutic Class English
Heat clearence
Therapeutic Class Chinese
清热
Functions
reduce heat in blood, relieve consumptive fever, and remove heat from the lung
Toxicity
NA
Geo-authentic habitats (道地产区)
Jiangsu Province,Shanghai
Reference
Chinese Pharmacopoeia (2015)
Barcode ID
Barcode Source

TCM Prescriptions with the Component

Prescription ID Prescription English Name Prescription Chinese Name
TCMF7259 秦艽鳖甲散
TCMF2377 Added Flavor Two Place Decoction 加味两地汤
TCMF3002 Bai Feng Yin 白凤饮
TCMF3298 Bao Gan Recipe 保肝合剂
TCMF2635 Boyun Tuiyi Pills 拨云退翳丸
TCMF1452 Boyun Tuiyi Pills 拨云退翳丸
TCMF3076 Bu Yi Di Huang Pills 补益地黄丸
TCMF615 Bu Yi Di Huang Pills 补益地黄丸
TCMF6024 Chang Chun Yao Wine 长春药酒
TCMF6032 Chang Chun Yi Shou Ointment 长春益寿膏
TCMFx3251 Chi Tong Ning 齿痛宁
TCMF3700 Da Hu Zhuang Yuan Pills 打虎壮元丸
TCMF2143 Decoction of Nelumbinis for Eliminating Heart Fire 清心莲子饮
TCMFx1838 Decoction of Rehmanniae and Obstetrics 两地汤
TCMFx3254 Di Gu Pi Lu 地骨皮露
TCMF7178 Di Zhen Granules 地贞颗粒
TCMFx2512 Empty Cave Tuberculosis Recipe
TCMF3375 Feng Shi Gao Yao 风湿膏药
TCMF3845 Fu Ke Bai Feng Tablets 妇科白凤片
TCMF3527 Gan Lu Xiao Ke Capsules 甘露消渴胶囊
TCMF3614 Gu Ben Yan Ling Pills 固本延龄丸
TCMF2659 Heart Clearing Lotus Seed Decoction 清心莲子饮
TCMF4028 Huan Jing Jian Oral Liquid 还精煎口服液
TCMF4232 Hui Chun Wine 回春酒
TCMFx2046 Hyperthermia Cooling Powder 清骨散
TCMFx4694 Jia Jian Di Huang Pills 加减地黄丸
TCMF4081 Jian Kang Bu Shen Wine 健康补肾酒
TCMF4492 Jiang Tang Ning Capsules 降糖宁胶囊
TCMF851 Jin Li Da Granules 津力达颗粒
TCMFx4017 Kang Shou Pills 康寿丸
TCMFx6967 Kang Shuai Lao Tablets 抗衰老片
TCMF4652 Kun Bao Pills 坤宝丸
TCMF669 Kun Bao Pills 坤宝丸
TCMFx2879 Liang Di Decoction 两地汤
TCMFx4668 Long Nao An Shen Pills 龙脑安神丸
TCMFx4806 Lu Tai Capsules 鹿胎胶囊
TCMFx4798 Lu Tai Ointment 鹿胎膏
TCMF2468 Lung Clearing Decoction
TCMF2194 Lung Dispersing Interior Modulation Recipe
TCMF2399 Lung Powder for Children
TCMFx4261 Man Shen Bao Recipe 慢肾宝合剂
TCMF4720 Nao Li Bao Pills 脑力宝丸
TCMF6949 Pi Min Xiao Capsules 皮敏消胶囊
TCMF1681 Powder for Expelling Lung Heat, Lung-Heat Expelling Powder 泻白散
TCMF2538 Powder of Astragali seu Hedysari and Carapax Trionycis 黄芪鳖甲散
TCMF2583 Powder of Ginseng and Astragali seu Hedysari 人参黄芪散
TCMF5244 Qing Gong Chang Chun Capsules 清宫长春胶囊
TCMF2858 Qing Gu Powder 清骨散
TCMF5333 Qing Jin Ning Fei Pills 清金宁肺丸
TCMFx2877 Qing Jing Powder 清经散
TCMFx5095 Qing Lin Pills 青麟丸
TCMF5722 Qing Shen Yin Infusion 清身饮冲剂
TCMF7325 Qing Xin Lian Zi Decoction 清心莲子饮
TCMF2830 Qing Xin Lian Zi Decoction 清心莲子饮
TCMF5814 Qing Xin Lian Zi Yin 清心莲子饮
TCMFx1849 QS Flower Powder Decoction
TCMFx5174 Qu Feng Shi Zhi Tong Powder 祛风湿止痛散
TCMFx2411 Radix Bupleuri Bone Soothing Powder 柴胡清骨散
TCMFx5669 Shang Ke Fu Yao 伤科敷药
TCMFx3517 Shen Rong Bian Pills 参茸鞭丸
TCMFx3541 Shen Rong Duo Bian Wine 参茸多鞭酒
TCMFx5105 Su Xiao Ya Tong Ning Ding 速效牙痛宁酊
TCMFx5144 Sun Shang Gu Yao Ointment 损伤骨药膏
TCMFx5160 Sun Shang Zhi Tong Ointment 损伤止痛膏
TCMFx2497 Three Excess Remover Decoction
TCMF5647 Tiao Jing Yi Ling Tablets 调经益灵片
TCMFx5163 Tou Gu Zhen Feng Pills 透骨镇风丸
TCMFx5370 Wu Gong Zhui Feng Ointment 蜈蚣追风膏
TCMFx7308 Wu Pi Decoction 五皮饮
TCMF5867 Xia Xiao Pills 下消丸
TCMF243 Xiao Er Fei Ke Granules 小儿肺咳颗粒
TCMF279 Xiao Er Gan Mao Granules 小儿感冒颗粒
TCMF277 Xiao Er Gan Mao Oral Liquid 小儿感冒口服液
TCMF278 Xiao Er Gan Mao Tea 小儿感冒茶
TCMFx6119 Xiao Er Ma Gan Infusion 小儿麻甘冲剂
TCMF6278 Xiao Er Qing Jie Infusion 小儿清解冲剂
TCMF6030 Xiao Feng Zhi Yang Granules 消风止痒颗粒
TCMF2829 Xie Bai Powder 泻白散
TCMF7391 Xie Bai Powder 泻白散
TCMFx6047 Yang Xue Tui Re Pills 养血退热丸
TCMF6597 Yi Qi Yang Xue Oral Liquid 益气养血口服液
TCMF932 Yi Qi Yang Xue Oral Liquid 益气养血口服液
TCMF2789 Yin Nourishing Real Treasure Decoction 滋阴至宝汤
TCMFx6306 Yu Biao Pills 鱼鳔丸
TCMF6543 Yu Yuan Pills 愈渊丸
TCMFx6833 Zhang Zhou Shen Qu 漳州神曲
TCMFx6310 Zheng Gu Ointment 正骨膏
TCMF7417 Zi Yin Di Huang Pills 滋阴地黄丸

Targeted Human Proteins by the Ingredient of Component

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT1 EHMT2 Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Transferase Q96KQ7
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT143 CA3 Carbonic anhydrase III Lyase P07451
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT166 AKR1C2 Aldo-keto reductase family 1 member C2 Oxidoreductase P52895
TCMT167 AKR1C3 Aldo-keto-reductase family 1 member C3 Oxidoreductase P42330
TCMT168 AKR1C4 Aldo-keto reductase family 1 member C4 Oxidoreductase P17516
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT18 GAA Lysosomal alpha-glucosidase Hydrolase P10253
TCMT22 ALPI Intestinal alkaline phosphatase Hydrolase P09923
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT281 DPP4 Dipeptidyl peptidase IV Unclassified P27487
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT61 MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 Unclassified Q07820
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372


Targeted Pathogenic Microbes by the Ingredient of Component

Target ID Target Name
TCMT1212 Verticillium dahliae
TCMT1218 Staphylococcus aureus
TCMT1463 Mycobacterium tuberculosis

Ingredient Structrues

Ingredient ID: TCMC948
Formula: C9H8O3

Ingredient ID: TCMC6160
Formula: C44H52N10O11

Ingredient ID: TCMC6159
Formula: C42H51N9O12

Ingredient ID: TCMC5294
Formula: C27H28N2O4

Ingredient ID: TCMC5103
Formula: C18H30O3

Ingredient ID: TCMC4682
Formula: C28H42N4O6

Ingredient ID: TCMC450
Formula: C9H10O3

Ingredient ID: TCMC4428
Formula: C18H32O3

Ingredient ID: TCMC4324
Formula: C29H48O

Ingredient ID: TCMC3755
Formula: C20H28O2

Ingredient ID: TCMC3652
Formula: C28H48O

Ingredient ID: TCMC3455
Formula: C27H28N2O4

Ingredient ID: TCMC3074
Formula: C23H48

Ingredient ID: TCMC3070
Formula: C33H68

Ingredient ID: TCMC3008
Formula: C30H60O2

Ingredient ID: TCMC2874
Formula: C17H23NO3

Ingredient ID: TCMC2835
Formula: C5H12NO2

Ingredient ID: TCMC1839
Formula: C7H6O3

Ingredient ID: TCMC1767
Formula: C18H19NO4

Ingredient ID: TCMC1050
Formula: C17H19NO4

Ingredient ID: TCMC1045
Formula: C9H10O4

Properties

Ingredient ID Formulae Name MW AlogP MlogP XlogP # HBA # HBD PSA # Rotatable Bond # Ring # Heacy Atom Lipinski RO5 Violation
TCMC450 C9H10O3 3-Hydroxy-1-(4-Hydroxyphenyl)Propan-1-One 166.06 -1.138 2.12 0.456 2 2 57.53 5 1 12 0
TCMC948 C9H8O3 Coumaric Acid 164.05 -0.339 2.12 1.886 2 2 57.53 4 1 12 0
TCMC1045 C9H10O4 Dihydrocaffeic Acid 182.06 -1.0632 2.01 0.886 2 3 77.76 6 1 13 0
TCMC1050 C17H19NO4 Dihydro-N-Caffeoyltyramine 301.13 -1.3223 2.78 2.764 2 4 93.28 10 2 22 0
TCMC1767 C18H19NO4 N-Trans-Feruloyl Tyramine 313.13 -0.6499 2.89 3.109 2 3 82.28 10 2 23 0
TCMC1839 C7H6O3 Paraben 138.03 -0.7001 1.9 1.07 2 2 57.53 3 1 10 0
TCMC2835 C5H12NO2 Betaine 117.0789786 -2.2564 1.68 -1.227 2 0 40.13 2 0 8 0
TCMC2874 C17H23NO3 Hyoscyamine 290.1756186 -3.3293 2.89 3.379 3 2 50.97 5 3 21 0
TCMC3008 C30H60O2 Myricyl Acid,Melissic Acid,Triacontanoic Acid 451.4515061 -8.6075 4.54 15.055 2 0 40.13 28 0 32 2
TCMC3070 C33H68 Triatricontane 464.5321022 -8.8254 5.09 19.117 0 0 0 30 0 33 2
TCMC3074 C23H48 N-Tricosane 324.3756015 -5.9454 3.99 13.427 0 0 0 20 0 23 2
TCMC3455 C27H28N2O4 Lyciumamide 444.2049074 -1.4219 3.77 9.175 6 2 84.5 13 3 33 2
TCMC3652 C28H48O Campesterol 400.3705162 1.9762 4.43 11.026 1 1 20.23 5 4 29 1
TCMC3755 C20H28O2 Sugiol 300.2089301 0.7759 3.44 6.294 1 1 37.3 1 3 22 1
TCMC4324 C29H48O Stigmasterol 412.3705162 1.2566 4.54 11.071 1 1 20.23 5 4 30 1
TCMC4428 C18H32O3 Α-Dimorphecolic Acid,9-Hydroxy-10E,12Z-Octadecadienoic Acid 295.2273199 -2.743 3.11 5.448 3 1 60.36 14 0 21 2
TCMC4682 C28H42N4O6 Kukoamine A 532.3260851 -6.8866 3.44 2.026 4 8 172.34 21 2 38 2
TCMC5103 C18H30O3 9-Hotre,(9S,10E,12Z,15Z)-9-Hydroxy-10,12,15-Octadecatrienoic Acid 293.2116698 -1.8924 3.11 5.121 3 1 60.36 13 0 21 2
TCMC5294 C27H28N2O4 Aurantiamide Acetate 444.2049074 -1.4219 3.77 9.175 6 2 84.5 13 3 33 2
TCMC6159 C42H51N9O12 Lyciumin A 872.357893 -8.0185 3.77 1.228 20 9 309.53 13 6 63 3
TCMC6160 C44H52N10O11 Lyciumin B 895.3738775 -7.9786 3.99 1.845 21 9 305.09 13 7 65 3

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1. General Information of the Component  
2. TCM Prescriptions with the Component  
3. Putative Targets  
4. Activity & References for Filtering Putative Targets  
5. Ingredient Data & Chemical Structure Information (Properties, InChI, InChIkey, SMILES, etc.)