TCM Prescription: Tiao Jing Yi Ling Tablets



Prescription Description
Prescription IDTCMF5647
Pinyin NameTiao Jing Yi Ling Pian
Chinese Name调经益灵片
English NameTiao Jing Yi Ling Tablets
Function Description月经失调, 带下病
IndicationsLeukorrhea disorder, Irregular menstruation
Disease ICD-11 Category SC20 [Leukorrhea disorder (TM1), 带下病 (TM1) ];
GA20.3 [Abnormal regularity of uterine bleeding, 子宫出血周期异常 ];
Human Tissues Associated with IndicationUterus
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH2265 Cyperus rotundus 香附 TCMH2265 GENG1049-15
TCMH449 Cortex lycii radicis 地骨皮 TCMH449
TCMH1721 Panax ginseng 人参 TCMH1721 GBVE1679-11
TCMH104 Paeonia lactiflora 白芍 TCMH104 ITSAH2416-14
TCMH12 Artemisia argyi 艾叶 TCMH12 ITSAE2504-14
TCMH1513 Paeonia moutan 牡丹皮 TCMH1513
TCMH178 Carapax trionycis 鳖甲 TCMH178
TCMH120 Atractylodes macrocephala 白术 TCMH120 ITSAN4430-14
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH981 Astragalus membranaceus 黄芪 TCMH981 ITSAK2981-14
TCMH1681 Artemisia carvifolia 青蒿 TCMH1681 KU555619
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT197 PDE4D Phosphodiesterase 4D Hydrolase Q08499
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT248 CXCL8 Interleukin-8 Unclassified P10145
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT287 TAS2R31 Taste receptor type 2 member 31 GPCR P59538
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT698 PDE4B Phosphodiesterase 4B Hydrolase Q07343
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT848 ERN1 Serine/threonine-protein kinase/endoribonuclease IRE1 Kinase O75460


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1172 Staphylococcus aureus subsp. aureus RN4220
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1283 Human enterovirus 71
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1292 Japanese encephalitis virus
TCMT1294 Human parainfluenza virus 3
TCMT1321 Staphylococcus hominis
TCMT1336 Yellow fever virus
TCMT1337 Dengue virus type 4
TCMT1338 Rift Valley fever virus
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 12.0502
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, EGFR, ESR1, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 11.8883
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.13
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, FUT7, HSPA1A, PIK3CA, PIM1, PPARA, PTGS1, PTGS2, TYR, XDH 11.1027
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TEK, TYR, XDH 9.99899
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, FLT3, GPR35, HCAR2, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 9.84846
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TYR 9.84846
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, FLT3, GPR35, HCAR2, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 9.83571
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TEK, TYR, XDH 9.2339
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, CDC25B, CSNK2A1, CXCL8, CYP1B1, EGFR, ESR1, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, PIM1, PTGS1, PTGS2, SMAD3, SRC, TEK, XDH 9.1081
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APP, AXL, CA9, CSNK2A1, CXCL8, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP3, HSD17B2, IGF1R, INSR, MMP2, MMP9, PIK3CA, PPARA, PTGS2, SRC, TEK, TYR 8.78889
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, APP, AXL, CA2, CA9, CSNK2A1, CXCL8, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, PIK3CA, PPARA, PTGS2, SMAD3, SRC, TEK, TYR 8.78298
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AURKB, AXL, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, F10, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 8.11239
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2 7.99766
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, F10, FABP3, FABP4, FLT3, GPR35, HCAR2, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, SMAD3, SRC, TEK, XDH 7.61535
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, EGFR, FABP3, FABP4, FUT7, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 7.61535
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, ESR1, HSD17B1, HSD17B2 7.61306
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AXL, CYP1B1, EGFR, F10, FLT3, GPR35, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 7.61306
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CXCL8, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, F10, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 7.61306
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, HCAR2, HSPA1A, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 7.61306
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2 7.6063
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APP, CA2, CA9, CSNK2A1, CXCL8, CYP1A2, EGFR, ESR1, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK 7.58876
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, APP, AXL, CSNK2A1, CYP1B1, EGFR, F10, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 7.53901
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, HCAR2, HSPA1A, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 7.52875
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CXCL8, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, F10, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 7.52875
[BP] GO:0042221 response to chemical AKR1B1, ALPL, APP, AXL, CA2, CA9, CSNK2A1, CXCL8, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, PIK3CA, PPARA, PTGS2, SMAD3, SRC, TEK, TYR 7.52281
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2 7.40724
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK 7.04004
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, FLT3, HCAR2, HSPA1A, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 6.89802
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, F10, FABP3, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 6.86933
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK 6.81702
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, APP, AXL, CSNK2A1, CXCL8, CYP1B1, EGFR, F10, FABP4, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 6.72332
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APP, CXCL8, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 6.70952
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC, TEK 6.43312
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 6.3951
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, FLT3, HSD17B2, INSR, KDR, PIK3CA, PPARA, SMAD3, SRC, TEK, TYR 6.39048
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APP, AXL, CA2, CA7, CSNK2A1, CXCL8, CYP19A1, CYP1B1, EGFR, F10, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK 6.34328
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APP, CXCL8, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 6.34328
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APP, AXL, CXCL8, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, PIK3CA, PTGS2, SMAD3, SRC 6.3041
[BP] GO:0033993 response to lipid ALPL, AXL, CA2, CA9, CSNK2A1, CXCL8, CYP1A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, HSD17B2, PTGS2, SRC, TYR 6.28073
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2 6.26082
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F10, INSR, MET, PIK3CA, PIK3CB, SRC, TEK 6.15298
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, F10, INSR, MET, PIK3CA, PIK3CB, SRC, TEK, XDH 6.14482
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK 6.13618
[BP] GO:0030335 positive regulation of cell migration APP, CXCL8, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 6.13175
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2 6.10509
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALPL, APP, AURKB, AXL, CA2, CA6, CA9, CSNK2A1, CXCL8, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, F10, FABP3, FABP4, FLT3, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TEK, TYR 5.97186
[BP] GO:2000147 positive regulation of cell motility APP, CXCL8, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 5.97186
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.9673
[BP] GO:0009725 response to hormone AKR1B1, ALPL, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, INSR, PPARA, PTGS2, SRC, TEK 5.9491
[BP] GO:0010035 response to inorganic substance AKR1B1, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, MMP9, PTGS2, SRC 5.94502
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, PPARA, PTGS1, PTGS2 5.93479
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APP, CXCL8, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 5.93479
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.93479
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.93479
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APP, CXCL8, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 5.92617
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH 5.91728
[BP] GO:0051272 positive regulation of cellular component movement APP, CXCL8, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 5.88491
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK 5.86922
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.72241
[BP] GO:0040017 positive regulation of locomotion APP, CXCL8, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 5.72241
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APP, AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TEK, XDH 5.67113
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, APP, AURKB, AXL, CSNK2A1, CXCL8, CYP1B1, DUSP3, EGFR, ESR1, F10, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.5796
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APP, AXL, CXCL8, CYP1A1, CYP1B1, EGFR, ESR1, FABP4, FLT3, IGF1R, INSR, KDR, MMP2, PIK3CA, PTGS2, SMAD3, SRC 5.57887
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.54021
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 5.5062
[BP] GO:0014070 response to organic cyclic compound ALPL, APP, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FLT3, PTGS2, SRC, TEK, TYR 5.49411
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.49411
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, APP, AURKB, CDC25B, CSNK2A1, CXCL8, CYP1B1, CYP2D6, DUSP3, EGFR, ESR1, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.38341
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APP, AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, TEK, XDH 5.32979
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, APP, CDC25B, DUSP3, EGFR, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.25868
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, APP, AURKB, AXL, CSNK2A1, CXCL8, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, F10, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.209
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, APP, CDC25B, DUSP3, EGFR, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.20599
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APP, AURKB, AXL, CA2, CA9, CXCL8, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, PIK3CA, PTGS2, PTPN1, SMAD3, SRC 5.19994
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, CYP2D6, DUSP3, ESR1, FABP4, GPR35, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC 5.12207
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AXL, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, F10, FABP4, HSD17B2, IGF1R, INSR, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, SMAD3, SRC, TEK, TYR 5.11448
[BP] GO:0080134 regulation of response to stress ADORA1, APP, CYP19A1, DUSP3, EGFR, ESR1, FABP4, HSPA1A, IGF1R, MET, MMP12, MMP2, NUAK1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.1085
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, APP, AURKB, AXL, CA2, CA9, CDC25B, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, FABP4, FLT3, FUT7, HSD17B2, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, SMAD3, SRC, TEK, TYR 5.06026
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, SRC, TEK 4.91786
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, FABP3, FABP4, FUT7, HSPA1A, MMP1, MMP12, MMP2, MMP9, PIK3CB, SRC, XDH 4.89103
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APP, AXL, CA12, CA2, CA7, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, INSR, MET, PIK3CA, PIK3CB, SMAD3, SRC 4.89057
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.82537
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, APP, CDC25B, EGFR, FABP3, FLT3, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.74679
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, APP, CDC25B, EGFR, FABP3, FLT3, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.74679
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, NQO2, PTGS1 4.67889
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, APP, AXL, CA2, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, FLT3, HSD17B2, INSR, KDR, MMP9, PIK3CA, PIM1, PPARA, PTGS2, SMAD3, SRC, TEK, TYR 4.64385
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AXL, CXCL8, CYP1B1, EGFR, ESR1, IGF1R, INSR, MMP2, MMP9, PIK3CA, PTGS2, SRC 4.50892
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 4.48868
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, AURKB, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.4862
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, CDC25B, CSNK2A1, EGFR, ESR1, FLT3, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, PIM1, PTGS2, TEK 4.47657
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.45634
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, AXL, CYP1B1, EGFR, HSPA1A, MMP9, PTGS1, PTGS2, SRC 4.43125
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 4.38148
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, EGFR, ESR1, FABP4, HSPA1A, MMP12, MMP2, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK 4.30174
[BP] GO:0042325 regulation of phosphorylation ADORA1, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, TEK, XDH 4.26798
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, CA12, CA2, CA7, EGFR, ESR1, FABP3, FABP4, GPR35, INSR, MET, PIK3CA, PIK3CB, SMAD3 4.13729
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 4.135
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, APP, CDC25B, EGFR, FLT3, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 4.13247
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 4.06769
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AURKB, AXL, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TEK, TYR, XDH 4.06769
[BP] GO:0032787 None ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, PPARA, PTGS1, PTGS2 4.06318
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AURKB, AXL, CDC25B, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TEK, TYR, XDH 3.99536
[BP] GO:0043408 regulation of MAPK cascade ADORA1, APP, DUSP3, EGFR, FLT3, IGF1R, INSR, KDR, PIK3CB, PTPN1, SRC, TEK, XDH 3.97293
[BP] GO:0043549 regulation of kinase activity ADORA1, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK 3.94377
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, APP, AURKB, AXL, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TYR, XDH 3.91828
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, APP, CDC25B, EGFR, FLT3, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 3.91828
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, CXCL8, DUSP3, EGFR, ESR1, GPR35, HSPA1A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SMAD3, SRC, XDH 3.90317
[BP] GO:0031399 regulation of protein modification process ADORA1, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 3.89607
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, CXCL8, DUSP3, EGFR, ESR1, GPR35, HSPA1A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SMAD3, SRC, XDH 3.89066
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, CA2, CYP1A1, EGFR, HSPA1A, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK, TYR 3.85419
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, HCAR2, HSD17B1, HSD17B2 3.84106
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, APP, CDC25B, CSNK2A1, EGFR, ESR1, FLT3, HSPA1A, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 3.84106
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, APP, EGFR, FLT3, INSR, KDR, PIK3CB, PTPN1, SRC, TEK, XDH 3.82833
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.82517
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK 3.80766
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, CA1, CSNK2A1, CXCL8, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK 3.7837
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.76353
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, PTGS2, SRC, TEK, TYR 3.74248
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, CXCL8, CYP19A1, DUSP3, EGFR, ESR1, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 3.73813
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, APP, AXL, CA2, CA9, CXCL8, CYP1A1, CYP1A2, CYP1B1, EGFR, HSPA1A, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TEK 3.72779
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EGFR 3.64554
[BP] GO:0008283 cell proliferation ACHE, AURKB, CYP1A1, EGFR, ESR1, FLT3, MET, PIK3CB, PIM1, SRC, TEK, TYR 3.63903
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 3.6275
[BP] GO:0051049 regulation of transport ACHE, ADORA1, APP, AXL, CA2, CA7, CYP19A1, EGFR, GPR35, HCAR2, HSPA1A, INSR, MMP12, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC 3.61915
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CXCL8, CYP19A1, EGFR, ESR1, FABP4, KDR, MET, MMP12, PPARA, PTGS2, SMAD3, TEK 3.61874
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, FUT7, GPR35, HCAR2, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TEK, TYR, XDH 3.61748
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, PIK3CA, PIK3CB, PTPN1, SRC 3.58762
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, APP, CDC25B, EGFR, ESR1, FLT3, HSPA1A, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 3.57745
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, FLT3, IGF1R, INSR, PIK3CB, PTPN1, SRC 3.57661
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2 3.54873
[BP] GO:0001525 angiogenesis CXCL8, CYP1B1, KDR, MMP2, PIK3CA, PIK3CB, PTGS2, TEK 3.52601
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APP, AURKB, AXL, CSNK2A1, CXCL8, CYP19A1, CYP1B1, CYP2D6, DUSP3, EGFR, ESR1, FABP3, FABP4, GPR35, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 3.49709
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, IGF1R, INSR, PPARA, PTGS2, SRC, TEK 3.49685
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK 3.49628
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APP, CXCL8, EGFR, ESR1, FLT3, IGF1R, INSR, MMP2, PTGS2, SMAD3, SRC 3.48432
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APP, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, PTGS2, SRC 3.48432
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, PTGS2, SRC, TEK, TYR 3.42684
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK 3.41112
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, EGFR, PTGS2 3.38713
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FLT3, HCAR2, PPARA, PTGS2, SRC, TEK 3.3778
[BP] GO:0016477 cell migration AXL, CXCL8, CYP1B1, EGFR, FUT7, KDR, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC, TEK 3.35915
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, PTGS2, SRC, TEK 3.35325
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, EGFR, HCAR2, KDR, PIK3CB, PTGS2, SRC 3.32225
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, EGFR 3.32225
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC, TEK 3.32225
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 3.32225
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.28712
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 3.28481
[BP] GO:0019752 carboxylic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, PIM1, PPARA, PTGS1, PTGS2, TYR 3.24525
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, PTGS2 3.17569
[BP] GO:0050727 regulation of inflammatory response ADORA1, CYP19A1, EGFR, ESR1, FABP4, PPARA, PTGS2, SMAD3, TEK 3.17219
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK 3.17202
[BP] GO:0040011 locomotion AXL, CXCL8, CYP1B1, EGFR, FUT7, KDR, MET, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC, TEK 3.13491
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, APP, AURKB, AXL, CSNK2A1, CXCL8, CYP19A1, CYP1B1, CYP2D6, DUSP3, EGFR, ESR1, FABP3, FABP4, GPR35, HCAR2, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 3.10297
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, PTGS2, TYR 3.02823
[BP] GO:1902532 negative regulation of intracellular signal transduction DUSP3, ESR1, HSPA1A, IGF1R, MET, MMP9, PTGS2, PTPN1, SRC, XDH 3.02823
[BP] GO:0002682 regulation of immune system process ADORA1, APP, AXL, CA2, CXCL8, CYP19A1, DUSP3, ESR1, HCAR2, HSPA1A, MMP12, MMP2, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC 3.01979
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AXL, CA2, CXCL8, CYP1B1, EGFR, HCAR2, HSPA1A, KDR, MET, MMP12, MMP9, PIM1, PTGS2, SMAD3, SRC, TEK 3.00038
[BP] GO:0031401 positive regulation of protein modification process ADORA1, APP, CDC25B, EGFR, FLT3, INSR, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TEK, XDH 3.00038
[BP] GO:0009894 regulation of catabolic process ADORA1, CSNK2A1, EGFR, HCAR2, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PPARA, PTPN1, SMAD3 2.98007
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, APP, AXL, CA2, CXCL8, CYP1B1, EGFR, ESR1, GPR35, HCAR2, HSPA1A, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIM1, PTGS2, SMAD3, SRC, TEK, XDH 2.98007
[BP] GO:0048870 cell motility AXL, CXCL8, CYP1B1, EGFR, FUT7, KDR, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, SRC, TEK 2.96821
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, EGFR, HSPA1A 2.96409
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.95642
[BP] GO:0071248 cellular response to metal ion CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 2.94802
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, EGFR, HCAR2, PIK3CB, PTGS2 2.93951
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, PTGS2, SMAD3 2.93951
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.93951
[BP] GO:0010038 response to metal ion APP, CA2, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 2.92529
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, APP, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 2.92006
[BP] GO:0044093 positive regulation of molecular function ADORA1, APP, AURKB, CDC25B, EGFR, ESR1, FLT3, HSPA1A, INSR, MET, MMP9, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK, XDH 2.9021
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC 2.9021
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.87598
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, INSR, PTGS2, SMAD3, XDH 2.87509
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.87509
[BP] GO:0030155 regulation of cell adhesion CXCL8, CYP1B1, DUSP3, KDR, NUAK1, PIK3CA, PIK3CB, PPARA, SMAD3, SRC, TEK 2.87509
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, EGFR, FLT3, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK 2.85764
[BP] GO:0043436 oxoacid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, PIM1, PPARA, PTGS1, PTGS2, TYR 2.85245
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, APP, AURKB, CDC25B, CSNK2A1, EGFR, ESR1, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 2.84429
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, APP, AURKB, CDC25B, EGFR, ESR1, FLT3, HSPA1A, INSR, PIK3CA, PIK3CB, PTPN1, SMAD3, SRC, TEK, XDH 2.84429
[BP] GO:0001775 cell activation ALOX5, APP, AXL, CXCL8, EGFR, FLT3, FUT7, HSPA1A, MMP9, PIK3CA, PIK3CB, SMAD3, SRC 2.80742
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, EGFR, FLT3, INSR, PIK3CA, PIK3CB, PTPN1, SRC, TEK 2.79365
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, APP, AXL, CA2, CYP19A1, EGFR, HCAR2, INSR, MMP12, PTGS2, SMAD3, SRC 2.79227
[BP] GO:0048732 gland development CSNK2A1, CYP19A1, EGFR, INSR, PIK3CA, SMAD3, TYR 2.78855
[BP] GO:0006082 organic acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, PIM1, PPARA, PTGS1, PTGS2, TYR 2.78666
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway HSPA1A, MMP9, PTGS2, PTPN1, SRC 2.78564
[BP] GO:0071363 cellular response to growth factor stimulus APP, CXCL8, EGFR, INSR, KDR, SMAD3, SRC 2.75986
[BP] GO:0051098 regulation of binding APP, AURKB, CYP2D6, MET, MMP9, PPARA, SMAD3, SRC 2.73809
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.72654
[BP] GO:2000377 regulation of reactive oxygen species metabolic process CYP1B1, EGFR, INSR, PTGS2, SMAD3, XDH 2.67908
[BP] GO:0050900 leukocyte migration CXCL8, FUT7, MMP1, MMP9, PIK3CA, PIK3CB, SRC, TEK 2.67731
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.67731
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.67731
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.67731
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.67731
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, MMP12, PPARA, SMAD3, TEK 2.66325
[BP] GO:0071241 cellular response to inorganic substance CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 2.6508
[BP] GO:0001952 regulation of cell-matrix adhesion KDR, PIK3CB, SMAD3, SRC, TEK 2.64161
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 2.62614
[BP] GO:0051726 regulation of cell cycle APP, AURKB, CDC25B, CSNK2A1, CXCL8, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, PTGS2, SMAD3, SRC 2.60477
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.5987
[BP] GO:0009895 negative regulation of catabolic process ADORA1, EGFR, HCAR2, MET, PIK3CA, PPARA, SMAD3 2.59382
[BP] GO:0051130 positive regulation of cellular component organization APP, AURKB, AXL, ESR1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, SMAD3, SRC, TEK 2.58966
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, EGFR, FLT3, INSR, PIK3CB, PTPN1, SRC 2.58685
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, CDC25B, CYP19A1, EGFR, ESR1, HSD17B2, INSR, PTGS2, SRC 2.57863
[BP] GO:0009611 response to wounding ACHE, ADORA3, CYP1A1, EGFR, PPARA, SMAD3 2.57117
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CSNK2A1, EGFR, F10, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 2.55436
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.55436
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.55436
[BP] GO:0009968 negative regulation of signal transduction CXCL8, DUSP3, EGFR, ESR1, HSPA1A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SMAD3, SRC, XDH 2.55436
[BP] GO:0045787 positive regulation of cell cycle APP, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, INSR, SRC 2.54682
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.54682
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.54538
[BP] GO:0022414 reproductive process AKR1B1, ALPL, APP, AXL, CDC25B, CYP19A1, CYP1A1, EGFR, ESR1, HSD17B2, INSR, MMP2, MMP9, PTGS2, SRC 2.53455
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade APP, DUSP3, EGFR, KDR, PTPN1, SRC, TEK 2.5115
[BP] GO:0009893 positive regulation of metabolic process ADORA1, APP, AURKB, CDC25B, CSNK2A1, EGFR, ESR1, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 2.51105
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CXCL8, CYP1A1, CYP1A2, PTGS2, SRC 2.48801
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.48279
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.48279
[BP] GO:0001503 ossification ALPL, EGFR, MMP2, MMP9, TEK 2.4811
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, APP, AURKB, CDC25B, EGFR, ESR1, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 2.4811
[BP] GO:0032103 positive regulation of response to external stimulus CXCL8, EGFR, FABP4, KDR, MET, PTGS2, SMAD3 2.4811
[BP] GO:0070848 response to growth factor APP, CXCL8, EGFR, INSR, KDR, SMAD3, SRC 2.4811
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, PPARA, SMAD3, TEK 2.4706
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, APP, AURKB, CDC25B, CSNK2A1, EGFR, ESR1, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 2.47021
[BP] GO:0006928 movement of cell or subcellular component APP, AXL, CXCL8, CYP1B1, EGFR, FUT7, KDR, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, TEK 2.46176
[BP] GO:0002009 morphogenesis of an epithelium CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.45955
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, EGFR, KDR, PTGS2, SRC 2.45955
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, DUSP3, EGFR, FLT3, IGF1R, INSR, PIK3CB, PTPN1, SRC 2.45586
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.44342
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APP, EGFR, IGF1R, INSR, MMP2, PTGS2, SRC 2.39672
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.39151
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, EGFR, FLT3, INSR, PIK3CA, PIK3CB, PTPN1, SRC 2.39094
[BP] GO:0019538 protein metabolic process ACHE, ALPL, APP, AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK 2.38878
[BP] GO:0080135 regulation of cellular response to stress APP, DUSP3, EGFR, HSPA1A, IGF1R, MET, NUAK1, PTGS2, PTPN1, XDH 2.35251
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CXCL8, CYP1A1, CYP1A2, PTGS2, SRC 2.34505
[BP] GO:0046486 glycerolipid metabolic process ACHE, CSNK2A1, EGFR, FABP3, FABP4, MET, PIK3CA, PIK3CB 2.34171
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.33937
[BP] GO:0043393 regulation of protein binding APP, AURKB, MET, MMP9, PPARA, SRC 2.31645
[BP] GO:0007346 regulation of mitotic cell cycle APP, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3 2.31645
[BP] GO:0033031 positive regulation of neutrophil apoptotic process HCAR2, PIK3CB 2.31645
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.31645
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.31645
[BP] GO:0051246 regulation of protein metabolic process ADORA1, APP, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 2.31645
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, CA2, CA7, EGFR, PTGS2 2.31645
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, CA2, CA7, EGFR, PTGS2 2.31645
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, MMP9, PTGS2, SMAD3, SRC, XDH 2.31645
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.31248
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APP, AURKB, CSNK2A1, CYP2D6, DUSP3, EGFR, ESR1, FABP4, HCAR2, HSPA1A, IGF1R, KDR, MET, MMP12, MMP9, PIK3CA, PPARA, PTGS2, PTPN1, SMAD3, SRC, XDH 2.31211
[BP] GO:0051894 None KDR, SMAD3, TEK 2.30276
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.30276
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, PTGS2 2.29807
[BP] GO:0050801 ion homeostasis APP, CA12, CA2, CA7, EGFR, ESR1, FABP3, GPR35, PIK3CB, SMAD3 2.27492
[BP] GO:1900182 positive regulation of protein localization to nucleus APP, EGFR, PTGS2, SMAD3, SRC 2.27173
[BP] GO:0030198 extracellular matrix organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.26849
[BP] GO:0090087 None ACHE, ADORA1, APP, CA2, EGFR, HCAR2, MMP12, PTGS2, PTPN1, SMAD3, SRC 2.26753
[BP] GO:0043062 extracellular structure organization APP, CYP1B1, KDR, MMP1, MMP12, MMP2, MMP9 2.26246
[BP] GO:0050927 None CXCL8, KDR, SMAD3 2.26088
[BP] GO:0010632 regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC, TEK 2.23495
[BP] GO:0032872 regulation of stress-activated MAPK cascade APP, DUSP3, EGFR, IGF1R, PTPN1, XDH 2.23495
[BP] GO:0070302 regulation of stress-activated protein kinase signaling cascade APP, DUSP3, EGFR, IGF1R, PTPN1, XDH 2.22712
[BP] GO:0032147 activation of protein kinase activity ADORA1, EGFR, INSR, PIK3CA, PIK3CB, PTPN1, SRC 2.22712
[BP] GO:0050926 None CXCL8, KDR, SMAD3 2.21822
[BP] GO:1903393 None KDR, SMAD3, TEK 2.21822
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APP, EGFR, IGF1R, INSR, MMP2, PTGS2, SRC 2.2123
[BP] GO:0048545 response to steroid hormone ALPL, CA2, EGFR, FLT3, PTGS2, SRC 2.20038
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.1702
[BP] GO:0006954 inflammatory response ADORA1, ADORA3, AXL, CXCL8, PIK3CA, PIK3CB, PTGS1, PTGS2 2.16884
[BP] GO:0044243 multicellular organismal catabolic process MMP1, MMP12, MMP2, MMP9 2.14948
[BP] GO:0044267 cellular protein metabolic process ALPL, APP, AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, IGF1R, INSR, KDR, MET, MMP1, MMP2, NUAK1, PIK3CA, PIM1, PTPN1, SMAD3, SRC, TEK 2.1313
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, APP, CXCL8, CYP1B1, FABP3, HSPA1A, PTGS2, SMAD3, XDH 2.12856
[BP] GO:0045931 positive regulation of mitotic cell cycle APP, CDC25B, CYP1A1, DUSP3, INSR 2.09181
[BP] GO:0033280 response to vitamin D ALPL, PTGS2, TYR 2.09181
[BP] GO:0031100 animal organ regeneration AXL, CSNK2A1, EGFR, FLT3 2.09181
[BP] GO:0050730 None ADORA1, APP, EGFR, FLT3, PTPN1, SRC 2.09052
[BP] GO:0006464 cellular protein modification process ALPL, APP, AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, PTPN1, SMAD3, SRC, TEK 2.07628
[BP] GO:0036211 protein modification process ALPL, APP, AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, PTPN1, SMAD3, SRC, TEK 2.07628
[BP] GO:0035556 intracellular signal transduction AKR1B1, AXL, CXCL8, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PTPN1, SRC, TEK 2.06617
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, SRC, TEK 2.05501
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR 2.05501
[BP] GO:2000116 regulation of cysteine-type endopeptidase activity CSNK2A1, MMP9, PTGS2, SMAD3, SRC, XDH 2.04745
[BP] GO:0044248 cellular catabolic process ACHE, AKR1B10, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, FABP3, FABP4, HSPA1A, PIK3CB, SRC, XDH 2.04294
[BP] GO:0022617 extracellular matrix disassembly MMP1, MMP12, MMP2, MMP9 2.03878
[BP] GO:0008217 None ADORA1, PPARA, PTGS1, PTGS2, SMAD3 2.03878
[BP] GO:1901890 None KDR, SMAD3, TEK 2.0219
[BP] GO:0071276 cellular response to cadmium ion CYP1A2, EGFR, MMP9 2.0219
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling IGF1R, PIK3CA, PIK3CB 2.0219
[BP] GO:0032963 collagen metabolic process MMP1, MMP12, MMP2, MMP9 2.00461
[CC] GO:0044432 endoplasmic reticulum part APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, EGFR, F10, FLT3, HSD17B2, PTGS1, PTGS2, PTPN1 2.73011
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, GPR35, HCAR2, HSD17B2, IGF1R, INSR, KDR, MET, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, SRC, TEK, TYR 2.5398
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX5, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, EGFR, ESR1, F10, FLT3, FUT7, GPR35, HCAR2, HSD17B2, IGF1R, INSR, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TEK, TYR 2.5398
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, EGFR, ESR1, F10, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTPN1, SMAD3, SRC, TEK 2.5115
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, TEK 2.50492
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, AURKB, CA1, CA2, CA4, CA5A, CA5B, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TYR, XDH 2.4
[CC] GO:0045121 membrane raft APP, EGFR, INSR, KDR, PTGS2, SRC, TEK 2.36688
[CC] GO:0098857 membrane microdomain APP, EGFR, INSR, KDR, PTGS2, SRC, TEK 2.3513
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 17.2356
[MF] GO:0046914 transition metal ion binding ALOX5, APP, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, ESR1, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, PTPN1, SMAD3, TYR, XDH 16.1521
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, DUSP3, EGFR, F10, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, SRC, TEK, TYR, XDH 14.7187
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, EGFR, ESR1, F10, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TEK, TYR, XDH 13.033
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.1373
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 9.90369
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6 8.60021
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2, SRC 7.82734
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.61306
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2, SRC 7.61306
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, SRC, TEK 7.24741
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2, TYR 7.24741
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, MMP1, MMP12, MMP2, MMP9, NQO2, PPARA, PTPN1, SMAD3 7.23095
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6 7.23095
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, ESR1, F10, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIM1, PPARA, PTGS1, PTGS2, PTPN1, SMAD3, TYR, XDH 7.08168
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH 7.03585
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.95798
[MF] GO:0046872 metal ion binding ALOX5, ALPL, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, ESR1, F10, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIM1, PPARA, PTGS1, PTGS2, PTPN1, SMAD3, TYR, XDH 6.74057
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 6.63962
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, TYR 6.3951
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, XDH 5.98995
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, HSD17B1, NQO2, PTGS1, PTGS2, SRC, XDH 5.76517
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6 5.66583
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.62853
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, SRC, TEK 5.20599
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 5.10096
[MF] GO:0043560 insulin receptor substrate binding IGF1R, INSR, PIK3CA, PIK3CB 5.10096
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP2D6 4.73266
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 4.64182
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR, NQO2 4.14891
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC 3.92294
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 3.82517
[MF] GO:0032403 protein complex binding ACHE, ADORA1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC 3.57151
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.41629
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, F10, FLT3, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PTPN1, SRC, TEK 3.24525
[MF] GO:0036094 small molecule binding ADORA1, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, XDH 3.04275
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.92863
[MF] GO:0008389 None CYP2A13, CYP2A6 2.92863
[MF] GO:0043168 anion binding APP, AURKB, AXL, CSNK2A1, EGFR, F10, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, XDH 2.84764
[MF] GO:0005524 ATP binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 2.67731
[MF] GO:0032559 adenyl ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 2.57831
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, NQO2, XDH 2.56008
[MF] GO:0030554 adenyl nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK 2.55436
[MF] GO:0000166 nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, XDH 2.4811
[MF] GO:1901265 nucleoside phosphate binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, SRC, TEK, XDH 2.4811
[MF] GO:0005518 collagen binding ACHE, MMP12, MMP9, SMAD3 2.34536
[MF] GO:0051425 None APP, INSR 2.31645
[MF] GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity EGFR, MET, PIK3CA, PIK3CB 2.29353
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.27173
[MF] GO:0052813 phosphatidylinositol bisphosphate kinase activity EGFR, MET, PIK3CA, PIK3CB 2.23169
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, HSD17B1, HSD17B2, XDH 2.1981
[MF] GO:0043559 insulin binding IGF1R, INSR 2.13479
[MF] GO:0035004 phosphatidylinositol 3-kinase activity EGFR, MET, PIK3CA, PIK3CB 2.13039
[MF] GO:0043548 phosphatidylinositol 3-kinase binding AXL, IGF1R, INSR 2.09181
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.0219
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, EGFR, ESR1, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, PPARA, TEK 2.00461


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 18.7194
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 11.3952
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 8.2749
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, EGFR, IGF1R 7.5481
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, INSR, ADORA1, PIK3CB, PTGS2, PTGS1 7.6566
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1, EGFR, HSPA1A 7.5481
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, CXCL8, PIK3CA, FLT3, MMP1, MMP2, PIK3CB, PTGS2, MMP9, MET, EGFR, IGF1R 7.0127
Bladder cancer_Homo sapiens_hsa05219 CXCL8, SRC, MMP1, MMP2, MMP9, EGFR 7.0664
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, SRC, INSR, KDR, TEK, PIK3CB, MET, EGFR, IGF1R 6.3406
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 6.2857
Ras signaling pathway_Homo sapiens_hsa04014 PIK3CA, INSR, KDR, TEK, PIK3CB, MET, EGFR, IGF1R 5.1024
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP2A6, CYP2A13, CYP2D6, CYP1A2, CYP1A1, CYP1B1 5.7196
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, CXCL8, PIK3CA, MMP2, PIM1, PIK3CB 5.0133
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, PTGS2 5.4541
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, INSR, TEK, PIK3CB, EGFR, IGF1R 4.991
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, SRC, KDR, PIK3CB, PTGS2 4.8297
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, INSR, PIK3CB, IGF1R, HSPA1A 4.7501
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, SRC, KDR, PIK3CB, MET, EGFR, IGF1R 4.5139
Metabolic pathways_Homo sapiens_hsa01100 AKR1B1, PTGS2, TYR, CYP19A1, PTGS1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH 4.3038
MicroRNAs in cancer_Homo sapiens_hsa05206 PIK3CA, PIM1, CYP1B1, PTGS2, MMP9, MET, EGFR, CDC25B 4.4487
Melanoma_Homo sapiens_hsa05218 PIK3CA, PIK3CB, MET, EGFR, IGF1R 4.5711
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, PIK3CB, MET, EGFR 4.6741
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, PIK3CA, INSR, PIK3CB, EGFR, IGF1R 4.4816
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 PIK3CA, INSR, KDR, TEK, PIK3CB, MET, EGFR, IGF1R 4.0652
Hepatitis B_Homo sapiens_hsa05161 SMAD3, CXCL8, PIK3CA, SRC, PIK3CB, MMP9 4.3038
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.9201
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, INSR, PIK3CB, PPARA 3.8055
Serotonergic synapse_Homo sapiens_hsa04726 APP, CYP2D6, ALOX5, PTGS2, PTGS1 3.7637
Hepatitis C_Homo sapiens_hsa05160 CXCL8, PIK3CA, PIK3CB, PPARA, EGFR 3.4763
Glioma_Homo sapiens_hsa05214 PIK3CA, PIK3CB, EGFR, IGF1R 3.5226
Phospholipase D signaling pathway_Homo sapiens_hsa04072 CXCL8, PIK3CA, INSR, PIK3CB, EGFR 3.3498
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 CXCL8, PIK3CA, INSR, PIK3CB, PPARA 3.2757
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, PIM1, PIK3CB 3.734
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, PIK3CA, PIK3CB, EGFR 3.5103
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, SRC, PIK3CB, PTGS2, EGFR 3.1946
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1 3.4133
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 CXCL8, SRC, MET, EGFR 3.4763
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, INSR, ADORA1, PIK3CB 3.1139
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, PIK3CB, EGFR, IGF1R 3.1228
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, SRC, PIK3CB, EGFR 3.1504
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 3.3011
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, INSR, PIK3CB, IGF1R 3.0517
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, CDC25B, IGF1R 3.011
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.4734
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 CXCL8, FLT3, MMP9, MET, IGF1R 3.011
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, PIK3CA, ADORA1, PIK3CB, PPARA 2.8377
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.8468
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3, CXCL8, PIK3CA, PIK3CB 2.9307
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, SRC, PIK3CB, ESR1 2.7731
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, PIK3CB, HSPA1A 2.7731
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, PIK3CB, PTGS1 2.7418
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.7731
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, ADORA3, ADORA1, PIK3CB 2.7535
Measles_Homo sapiens_hsa05162 CSNK2A1, PIK3CA, PIK3CB, HSPA1A 2.5875
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, INSR, PIK3CB, IGF1R 2.7226
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, PIK3CA, PIK3CB, IGF1R 2.5456
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 CXCL8, FLT3, KDR, MET, EGFR 2.4126
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PIK3CA, INSR, PIK3CB 2.5732
Influenza A_Homo sapiens_hsa05164 CXCL8, PIK3CA, PIK3CB, HSPA1A 2.2581
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, PIK3CB, HSPA1A 2.0825
Chemokine signaling pathway_Homo sapiens_hsa04062 CXCL8, PIK3CA, SRC, PIK3CB 2.1735
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 PIK3CA, SRC, PIK3CB, EGFR 2.0188
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, CDC25B, HSPA1A 1.7752
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, PIK3CB 2.0942
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 2.1735
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3506
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.343
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSPA1A 0.3609
Calcium signaling pathway_Homo sapiens_hsa04020 EGFR 0.349
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3498
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.3609
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, PIM1, PIK3CB 1.6029
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.3882
Rheumatoid arthritis_Homo sapiens_hsa05323 CXCL8, MMP1, TEK 2.1755
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 CXCL8, PIK3CA, PIK3CB 2.0311
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, PIK3CA, PIK3CB 1.9859
Viral carcinogenesis_Homo sapiens_hsa05203 PIK3CA, SRC, PIK3CB 1.3397
Amoebiasis_Homo sapiens_hsa05146 CXCL8, PIK3CA, PIK3CB 2.0825
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB, EGFR 2.0792
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GPR35, ADORA3, ADORA1 1.052
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.4306
HTLV-I infection_Homo sapiens_hsa05166 SMAD3, PIK3CA, PIK3CB 1.1161
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3, PIK3CA, PIK3CB 2.4105
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, PIK3CB, PTGS2 2.2255
Axon guidance_Homo sapiens_hsa04360 MET 0.4465
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4548
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CXCL8, CSNK2A1, PTGS2 2.1526
Apoptosis_Homo sapiens_hsa04210 PIK3CA, PIK3CB 0.9759
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.9776
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 0.9957
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, PIK3CB 0.9508
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.9694
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 1.0086
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, PIK3CB 1.069
Melanogenesis_Homo sapiens_hsa04916 TYR 0.523
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.523
Cell cycle_Homo sapiens_hsa04110 SMAD3, CDC25B 1.052
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5337
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PTGS2 0.523
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5328
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB, EGFR 2.7496
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 2.5177
Colorectal cancer_Homo sapiens_hsa05210 SMAD3, PIK3CA, PIK3CB 2.5732
Non-small cell lung cancer_Homo sapiens_hsa05223 PIK3CA, PIK3CB, EGFR 2.6776
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5467
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 1.1715
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.553
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.553
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.5611
Salmonella infection_Homo sapiens_hsa05132 CXCL8 0.5555
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PIK3CB 1.2466
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 1.2096
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5519
Peroxisome_Homo sapiens_hsa04146 XDH 0.5626
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP2D6, CYP1A2 2.4684
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PIK3CA, INSR, PIK3CB 3.0173
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, INSR, PIK3CB 2.8122
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1 2.5305
Complement and coagulation cascades_Homo sapiens_hsa04610 F10 0.5781
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.5953
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5935
Pertussis_Homo sapiens_hsa05133 CXCL8 0.5916
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.5847
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.6048
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, PTGS2, PTGS1 2.5732
Gap junction_Homo sapiens_hsa04540 SRC, EGFR 1.2862
Bile secretion_Homo sapiens_hsa04976 CA2 0.6028
RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 CXCL8 0.6048
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.6295
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3 0.6269
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6515
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.4274
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 1.4761
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 3.011
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.4455
NOD-like receptor signaling pathway_Homo sapiens_hsa04621 CXCL8 0.6682
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.5694
Shigellosis_Homo sapiens_hsa05131 CXCL8, SRC 1.5084
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.7416
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.5786
Legionellosis_Homo sapiens_hsa05134 CXCL8, HSPA1A 1.6273
Malaria_Homo sapiens_hsa05144 CXCL8, MET 1.7183
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.7752
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.8579
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.7662
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.8579
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.9007
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.9508
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.9248
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 2.0825
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.9551
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 2.038
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.9508
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.4046
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.9582
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.2581
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.1721


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)