TCM Prescription: Xiao Feng Zhi Yang Granules



Prescription Description
Prescription IDTCMF6030
Pinyin NameXiao Feng Zhi Yang Ke Li
Chinese Name消风止痒颗粒
English NameXiao Feng Zhi Yang Granules
Function Description麻疹, 湿疹
IndicationsMeasles, Eczema
Disease ICD-11 Category 1F03 [Measles, 麻疹 ];
EA8Z [Dermatitis or eczema, unspecified, 皮炎或湿疹，未特指 ];
Human Tissues Associated with IndicationSkin
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH562 Saposhnikovia divaricata 防风 TCMH562 ITSAE3225-14
TCMH235 Periostracum cicadae 蝉蜕 TCMH235
TCMH449 Cortex lycii radicis 地骨皮 TCMH449
TCMH211 Atractylodes lancea 苍术 TCMH211 ITSAN4439-14
TCMH2367 Linum usitatissimum 亚麻子 TCMH2367 PLTOR003-08
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH451 Rehmannia glutinosa 地黄 TCMH451 ITSAH4578-14
TCMH718 Aristolochia manshuriensis 关木通 TCMH718 GBVE2055-11
TCMH1141 Schizonepeta tenuifolia 荆芥 TCMH1141 ITSAL858-14
TCMH1931 Gypsum fibrosum 石膏 TCMH1931
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT230 HSD17B3 Estradiol 17-beta-dehydrogenase 3 Oxidoreductase P37058
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT290 CHRM5 Muscarinic acetylcholine receptor M5 GPCR P08912
TCMT291 CHRM3 Muscarinic acetylcholine receptor M3 GPCR P20309
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT725 CACNA1C Voltage-gated L-type calcium channel alpha-1C subunit Ion channel Q13936
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT783 NR3C2 Mineralocorticoid receptor Nuclear receptor P08235
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT904 PGR Progesterone receptor Nuclear receptor P06401
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718
TCMT99 SHBG Testis-specific androgen-binding protein Unclassified P04278


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1250 Vesicular stomatitis virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1293 Vaccinia virus
TCMT1294 Human parainfluenza virus 3
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 12.0502
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.072
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 9.79374
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 9.77591
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, KIT, PPARA 8.28446
[BP] GO:0033993 response to lipid ALPL, AR, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, NR3C1, RORC, TYR 7.74264
[BP] GO:0043401 steroid hormone mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, RORC 7.7184
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 7.5635
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, AOX1, AR, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, KIT, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PPARA, PTPN1, RORC, TNKS, TNKS2, TYR, XDH 7.31671
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, AOX1, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FUT7, GBA2, HSD17B3, PPARA, TYR, XDH 7.07451
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, RORC 6.90022
[BP] GO:0009755 hormone-mediated signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, RORC 6.73457
[BP] GO:0009725 response to hormone AKR1B1, ALPL, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, KIT, NR3C1, PPARA 6.49853
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, AR, BCL2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, HSD11B2, HSD17B2, MMP2, MMP9, NR3C1, PPARA, RORC, TYR 6.40203
[BP] GO:0007197 None CHRM1, CHRM2, CHRM3, CHRM5 6.40203
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CACNA1C, CYP19A1, CYP1A1, CYP1B1, ESR1, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 6.12902
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 6.08387
[BP] GO:0006352 DNA-templated transcription, initiation AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, RORC 6.02767
[BP] GO:0014070 response to organic cyclic compound ALPL, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FLT3, HSD11B2, NR3C1, RORC, TYR 6.02767
[BP] GO:0007207 None CHRM1, CHRM2, CHRM3, CHRM5 6.01192
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2, HSD17B3 5.80984
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, AR, BCL2, CA2, CACNA1C, CDK6, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, HSD17B3, KIT, MMP9, PGR, PPARA, RORC, TYR 5.48645
[BP] GO:0030522 intracellular receptor signaling pathway AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, PGR, PPARA, RORC 5.44817
[BP] GO:0048513 animal organ development ACHE, AR, BCL2, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, HSD17B3, KIT, PPARA, TYR 5.44817
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.44817
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, AR, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, KIT, MMP2, NR3C1, PPARA, RORC, TYR 5.25129
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 5.2332
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, AR, BCL2, CA12, CA2, CA7, CACNA1C, CDK6, CHRM1, CHRM3, CYP19A1, CYP1A1, CYP1B1, ESR1, F3, FABP3, FABP4, FLT3, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, KIT, PPARA, TNKS, TNKS2, XDH 5.13658
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, AR, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, KIT, MMP2, NR3C1, PPARA 5.12139
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALPL, AOX1, AR, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GBA2, HSD17B1, HSD17B2, HSD17B3, KIT, MMP1, MMP2, NR3C1, NR3C2, PGR, PPARA, PTPN1, RORC, TNKS, TNKS2, TYR, XDH 4.93468
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, TYR, XDH 4.90155
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, AR, BCL2, CA2, CA9, CACNA1C, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD17B2, HSD17B3, KIT, MMP2, MMP9, PGR, PPARA, RORC, TNKS2, TYR 4.79495
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, AR, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, CYP1B1, ESR1, ESRRA, F3, FABP3, FLT3, KIT, MMP12, MMP2, MMP9, PGR, XDH 4.78479
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.28993
[BP] GO:0042221 response to chemical AKR1B1, ALPL, AR, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, KIT, MMP2, MMP9, NR3C1, PPARA, RORC, TYR 4.22496
[BP] GO:0007213 None CHRM1, CHRM2, CHRM3, CHRM5 4.15404
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 4.14028
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 4.11467
[BP] GO:0095500 None CHRM1, CHRM2, CHRM3, CHRM5 3.53175
[BP] GO:1903831 None CHRM1, CHRM2, CHRM3, CHRM5 3.53175
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 3.51958
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AR, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, ESR1, F3, FLT3, KIT, MMP12, MMP2, MMP9 3.47771
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.47116
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, AR, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, FLT3, HCAR2, KIT, MMP12, MMP9, PTPN1, TNKS, TNKS2, XDH 3.46384
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.45904
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.45904
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, AR, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F3, FLT3, HCAR2, KIT, MMP12, MMP9, PTPN1, TNKS, TNKS2, XDH 3.45272
[BP] GO:0007271 None CHRM1, CHRM2, CHRM3, CHRM5 3.28421
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, AOX1, AR, BCL2, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, KIT, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PPARA, PTPN1, RORC, TNKS, TNKS2, TYR, XDH 3.26286
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALPL, AR, BCL2, CACNA1C, CHRM1, CHRM3, CHRM5, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, F3, FABP4, HSD11B2, HSD17B2, KIT, MMP1, MMP12, MMP2, MMP9, PPARA, RORC, TNKS2, TYR 3.2502
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, AR, BCL2, CA2, CA7, CDC25B, CDK6, CHRM1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, HCAR2, KIT, MMP1, MMP12, MMP2, MMP9, NR3C1, PGR, PPARA, PTPN1, RORC, TNKS, TNKS2, XDH 3.21093
[BP] GO:0006940 None ADORA1, CHRM1, CHRM2, CHRM3, KIT 3.17519
[BP] GO:0035265 organ growth AR, BCL2, CYP19A1, ESR1 3.12499
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, FABP4, FUT7, GBA2, KIT, PPARA 3.10702
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, GBA2 3.09568
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CHRM5, CYP1A1, FABP3, FLT3, HCAR2, KIT, PPARA, RORC 3.09568
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, AR, BCL2, CA2, CA7, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HCAR2, KIT, MMP1, MMP12, MMP2, MMP9, NR3C1, PGR, PPARA, PTPN1, RORC, TNKS, TNKS2, XDH 3.09568
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.99322
[BP] GO:0003006 developmental process involved in reproduction ALPL, AR, BCL2, CDC25B, CYP19A1, ESR1, ESRRB, HSD17B2, HSD17B3, KIT, PGR 2.97438
[BP] GO:0007193 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5 2.89529
[BP] GO:0002320 lymphoid progenitor cell differentiation BCL2, FLT3, KIT 2.88782
[BP] GO:0060736 prostate gland growth AR, CYP19A1, ESR1 2.88782
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, FUT7, GBA2, MMP1, MMP12, MMP2, MMP9, XDH 2.8853
[BP] GO:0030518 intracellular steroid hormone receptor signaling pathway AR, ESR1, ESR2, NR3C1, PGR 2.85716
[BP] GO:0022414 reproductive process AKR1B1, ALPL, AR, BCL2, CDC25B, CYP19A1, CYP1A1, ESR1, ESRRB, HSD11B2, HSD17B2, HSD17B3, KIT, MMP2, MMP9, PGR 2.77577
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, AOX1, AR, BCL2, CDC25B, CDK6, CHRM1, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, KIT, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PPARA, PTPN1, RORC, TNKS, TNKS2, TYR, XDH 2.75017
[BP] GO:0048545 response to steroid hormone ALPL, AR, BCL2, CA2, FLT3, HSD11B2, NR3C1 2.75017
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, AR, BCL2, CA1, CA2, CACNA1C, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, KIT, MMP2, MMP9, NR3C1, NR3C2, PGR, PPARA, PTPN1, RORC, TNKS, TNKS2 2.75017
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, BCL2, CYP19A1, CYP1A1, CYP1B1, GBA2, HSD17B3, TYR 2.70973
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.69678
[BP] GO:0008283 cell proliferation ACHE, AR, BCL2, CHRM1, CHRM3, CHRM5, CYP1A1, ESR1, FLT3, KIT, TYR 2.68197
[BP] GO:0007200 None CHRM1, CHRM2, CHRM3, CHRM5, ESR1 2.67922
[BP] GO:0009115 None AOX1, XDH 2.67922
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 2.56301
[BP] GO:0006937 None ADORA1, CACNA1C, CHRM1, CHRM2, CHRM3, KIT 2.51213
[BP] GO:0033559 unsaturated fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 2.46867
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 2.41169
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, AR, CYP1A1, CYP1B1, ESR1, FLT3, NR3C1, RORC 2.40021
[BP] GO:0010035 response to inorganic substance AKR1B1, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KIT, MMP9 2.39188
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, AR, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, KIT, MMP2, MMP9, NR3C1, RORC 2.36425
[BP] GO:0006690 icosanoid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 2.3433
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.31114
[BP] GO:0032844 regulation of homeostatic process ADORA1, BCL2, CA2, CA7, CACNA1C, CDK6, HCAR2, TNKS, TNKS2 2.31114
[BP] GO:0060748 None AR, PGR 2.25929
[BP] GO:0046110 None AOX1, XDH 2.25929
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.25929
[BP] GO:0048608 reproductive structure development AR, BCL2, CYP19A1, ESR1, HSD17B2, HSD17B3, KIT 2.25929
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, RORC 2.18136
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, AR, BCL2, CDK6, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, KIT, MMP2, NR3C1, RORC 2.15636
[BP] GO:0048511 rhythmic process BCL2, CSNK2A1, ESR1, KIT, PGR, PPARA, RORC 2.13279
[BP] GO:0006631 fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA 2.02567
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.02012
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, GBA2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, NR3C2 2.70392
[CC] GO:0044432 endoplasmic reticulum part BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FLT3, GBA2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, NR3C2, PTPN1 2.45496
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, AOX1, AR, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA7, CACNA1C, CDC25B, CDK6, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, KIT, MMP2, MMP9, NR3C1, NR3C2, PGR, PTPN1, TNKS, TNKS2, TYR, XDH 1.70774
[CC] GO:0032279 None CHRM2, CHRM3 1.48726
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALPL, AR, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CHRM1, CHRM2, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, F3, FLT3, FUT7, GBA2, HCAR2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, KIT, MMP2, NR3C2, PGR, PTPN1, TNKS, TNKS2, TYR 1.48726
[MF] GO:0046914 transition metal ion binding AOX1, AR, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PPARA, PTPN1, RORC, TNKS, TYR, XDH 20.779
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 17.5367
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PPARA, PTPN1, RORC, TNKS 13.5718
[MF] GO:0005496 steroid binding AR, ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, NR3C1, NR3C2, PGR, RORC, SHBG 12.3055
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.072
[MF] GO:0003707 steroid hormone receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, NR3C1, NR3C2, PGR, PPARA, RORC 10.8677
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 9.81654
[MF] GO:0043169 cation binding ACHE, ALPL, AOX1, AR, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CHRM3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, KIT, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PPARA, PTPN1, RORC, TNKS, TNKS2, TYR, XDH 8.78944
[MF] GO:0043167 ion binding ACHE, ALPL, AOX1, AR, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CDK6, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HSD17B1, KIT, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PPARA, PTPN1, RORC, TNKS, TNKS2, TYR, XDH 8.23693
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding AR, ESR1, ESR2, ESRRA, ESRRB, PGR, PPARA, RORC 8.23693
[MF] GO:0004879 nuclear receptor activity AR, ESR1, ESR2, ESRRA, ESRRB, PGR, PPARA, RORC 8.23693
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, AOX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM3, CHRM5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, F3, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, KIT, MMP1, MMP12, MMP2, MMP9, PTPN1, TNKS, TNKS2, TYR, XDH 8.12982
[MF] GO:0046872 metal ion binding ALPL, AOX1, AR, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, ESR1, ESR2, ESRRA, ESRRB, KIT, MMP1, MMP12, MMP2, MMP9, NR3C1, NR3C2, PGR, PPARA, PTPN1, RORC, TNKS, TNKS2, TYR, XDH 7.74997
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 6.67849
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 6.40203
[MF] GO:0008289 lipid binding AR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, HSD11B2, HSD17B1, NR3C1, NR3C2, PGR, PPARA, RORC, SHBG 6.40203
[MF] GO:0016907 None CHRM1, CHRM2, CHRM3, CHRM5 6.40203
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, XDH 6.30824
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, TYR, XDH 6.01354
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 5.25129
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AR, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, KIT, NR3C1, NR3C2, PGR, PPARA, RORC 5.2332
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 4.92898
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 4.90694
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AR, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, KIT, NR3C1, NR3C2, PGR, PPARA, RORC 4.90694
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 4.7958
[MF] GO:0005506 iron ion binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, XDH 4.63441
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AR, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, KIT, NR3C1, NR3C2, PGR, PPARA, RORC 4.45472
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 4.28993
[MF] GO:0015464 None CHRM1, CHRM2, CHRM3, CHRM5 3.95048
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13 3.89085
[MF] GO:0042562 hormone binding ACHE, AR, CHRM3, HSD17B1, NR3C1, SHBG 3.89085
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AR, CHRM1, CHRM2, CHRM3, CHRM5, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, KIT, NR3C1, NR3C2, PGR, PPARA, RORC 3.83204
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 3.56807
[MF] GO:0004629 None ADORA1, CHRM1, CHRM3, CHRM5 3.12499
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 2.97746
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, HSD11B2, HSD17B1, XDH 2.97746
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6 2.94366
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 2.82763
[MF] GO:0099528 None CHRM1, CHRM2, CHRM3, CHRM5 2.77676
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.67922
[MF] GO:0003845 None HSD11B1, HSD11B2 2.67922
[MF] GO:0008389 None CYP2A13, CYP2A6 2.67922
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.57409
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, XDH 2.27447
[MF] GO:0008227 None CHRM1, CHRM2, CHRM3, CHRM5 2.18339
[MF] GO:0000978 None AR, ESR1, ESR2, ESRRA, NR3C1, PGR, PPARA, RORC 2.09409


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 18.7948
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, HSD17B3, CYP1B1, CYP19A1 10.8508
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, CHRM3, CHRM1, CHRM5, BCL2, CACNA1C 5.502
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 5.3557
Ovarian steroidogenesis_Homo sapiens_hsa04913 HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1 4.9562
Metabolic pathways_Homo sapiens_hsa01100 HSD17B3, AKR1B1, TYR, GBA2, CYP19A1, HSD11B1, CYP2A6, FUT7, AKR1B10, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 4.5945
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1 5.1492
Pathways in cancer_Homo sapiens_hsa05200 AR, CDK6, FLT3, MMP1, MMP2, KIT, BCL2, MMP9 3.2995
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 3.9041
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, CHRM3, CHRM1, ADORA3, CHRM5, ADORA1, NR3C1 3.3774
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, CHRM1, ADORA1, CACNA1C, PPARA 3.2995
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1 3.2205
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, CHRM3, CHRM1, CHRM5, CACNA1C 2.605
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.1508
Estrogen signaling pathway_Homo sapiens_hsa04915 MMP2, MMP9, ESR1, ESR2 2.605
Bladder cancer_Homo sapiens_hsa05219 MMP1, MMP2, MMP9 2.605
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, BCL2, CYP1B1, MMP9, CDC25B 1.7352
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, CYP1A2, AOX1 1.9666
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, F3 1.5832
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, CDK6, CHRM1, KIT, BCL2 1.5627
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM3, CHRM1, CHRM5 1.5627
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.4887
Hepatitis B_Homo sapiens_hsa05161 CDK6, BCL2, MMP9 1.2928
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1, CACNA1C 1.1901
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.1442
Proteoglycans in cancer_Homo sapiens_hsa05205 MMP2, MMP9, ESR1 1.0491
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.229
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, KIT 1.2278
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.5832
Prolactin signaling pathway_Homo sapiens_hsa04917 ESR1, ESR2 1.1093
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.2123
Gastric acid secretion_Homo sapiens_hsa04971 CHRM3, CA2 1.1089
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, KIT 1.1565
Renin secretion_Homo sapiens_hsa04924 ADORA1, CACNA1C 1.1704
Taste transduction_Homo sapiens_hsa04742 CHRM3, CACNA1C 1.0373
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1 1.1089
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2, NR3C2 1.4887
Insulin secretion_Homo sapiens_hsa04911 CHRM3, CACNA1C 1.0287
Prostate cancer_Homo sapiens_hsa05215 AR, BCL2 1.0203
GnRH signaling pathway_Homo sapiens_hsa04912 MMP2, CACNA1C 1.0118
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.3645
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.5328
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, BCL2 1.0287
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PGR, CDC25B 0.9796
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 1.0203
Melanogenesis_Homo sapiens_hsa04916 KIT, TYR 0.9722
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.7572
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.5627
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 0.9215
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 1.0036
Pancreatic secretion_Homo sapiens_hsa04972 CHRM3, CA2 0.9872
Oocyte meiosis_Homo sapiens_hsa04114 AR, PGR 0.8533
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.5253
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1 0.7908
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.8722
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2, CACNA1C 0.7464
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 0.8533
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, AOX1 0.7282
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.5819
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9 0.6469
MAPK signaling pathway_Homo sapiens_hsa04010 CACNA1C, CDC25B 0.4987
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT 0.4976
Endocytosis_Homo sapiens_hsa04144 KIT 0.2426
Ras signaling pathway_Homo sapiens_hsa04014 KIT 0.277
Rap1 signaling pathway_Homo sapiens_hsa04015 KIT 0.2956
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6 0.301
Focal adhesion_Homo sapiens_hsa04510 BCL2 0.3022
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3353
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.345
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3262
Tuberculosis_Homo sapiens_hsa05152 BCL2 0.3352
Apoptosis_Homo sapiens_hsa04210 BCL2 0.3854
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.3854
Alzheimer's disease_Homo sapiens_hsa05010 CACNA1C 0.345
Tight junction_Homo sapiens_hsa04530 CSNK2A1 0.3854
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.3717
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 ESRRB 0.3854
Oxytocin signaling pathway_Homo sapiens_hsa04921 CACNA1C 0.3601
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4252
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.3854
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.3893
Phospholipase D signaling pathway_Homo sapiens_hsa04072 KIT 0.3843
Glutamatergic synapse_Homo sapiens_hsa04724 CACNA1C 0.4204
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.4179
Dopaminergic synapse_Homo sapiens_hsa04728 CACNA1C 0.3962
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 ESR1 0.4179
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4481
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2 0.445
Serotonergic synapse_Homo sapiens_hsa04726 CACNA1C 0.4227
Toxoplasmosis_Homo sapiens_hsa05145 BCL2 0.4179
Vascular smooth muscle contraction_Homo sapiens_hsa04270 CACNA1C 0.4179
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CACNA1C 0.4481
Circadian entrainment_Homo sapiens_hsa04713 CACNA1C 0.4623
GABAergic synapse_Homo sapiens_hsa04727 CACNA1C 0.4697
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6 0.4976
Glioma_Homo sapiens_hsa05214 CDK6 0.4987
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.4697
Salivary secretion_Homo sapiens_hsa04970 CHRM3 0.4697
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4623
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4697
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 CACNA1C 0.4774
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.4697
Dilated cardiomyopathy_Homo sapiens_hsa05414 CACNA1C 0.4697
Long-term potentiation_Homo sapiens_hsa04720 CACNA1C 0.4987
Melanoma_Homo sapiens_hsa05218 CDK6 0.4987
Pancreatic cancer_Homo sapiens_hsa05212 CDK6 0.4987
Amphetamine addiction_Homo sapiens_hsa05031 CACNA1C 0.4987
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.4987
Cardiac muscle contraction_Homo sapiens_hsa04260 CACNA1C 0.4823
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.4987
Peroxisome_Homo sapiens_hsa04146 XDH 0.4774
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.4821
Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 CACNA1C 0.4774
Bile secretion_Homo sapiens_hsa04976 CA2 0.4987
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.4987
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.4987
Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 CACNA1C 0.4976
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6 0.5321
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.5635
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.5819
Type II diabetes mellitus_Homo sapiens_hsa04930 CACNA1C 0.5819
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.5819
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.5819
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.7307
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7231
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7307
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7481
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.7282
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7464
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.8722
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.9547
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.1611


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)