TCM Prescription: Fu Ke Bai Feng Tablets



Prescription Description
Prescription IDTCMF3845
Pinyin NameFu Ke Bai Feng Pian
Chinese Name妇科白凤片
English NameFu Ke Bai Feng Tablets
Function Description月经失调, 痛经
IndicationsDysmenorrhea disorder, Dysmenorrhea, Irregular menstruation
Disease ICD-11 Category SB96 [Dysmenorrhea disorder (TM1), 痛经 (TM1) ];
GA34.3 [Dysmenorrhoea, 痛经 ];
GA20.3 [Abnormal regularity of uterine bleeding, 子宫出血周期异常 ];
Human Tissues Associated with IndicationUterus
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH2183 Gallus domesticus 乌鸡 TCMH2183
TCMH12 Artemisia argyi 艾叶 TCMH12 ITSAE2504-14
TCMH1588 Achyranthes bidentata 牛膝 TCMH1588 ITSAJ4612-14
TCMH228 Bupleurum chinense 柴胡 TCMH228 ITSAM2218-14
TCMH1059 Glycine max 姜 TCMH1059 ITSAJ4675-14
TCMH104 Paeonia lactiflora 白芍 TCMH104 ITSAH2416-14
TCMH1513 Paeonia moutan 牡丹皮 TCMH1513
TCMH2265 Cyperus rotundus 香附 TCMH2265 GENG1049-15
TCMH2376 Corydalis yanhusuo 延胡索 TCMH2376
TCMH2624 Anemarrhena asphodeloides 知母 TCMH2624 GBVA3255-11, GBVU1201-13
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH972 Coptis chinensis 黄连 TCMH972 ITSAO4469-14
TCMH1673 Gentiana macrophylla 秦艽 TCMH1673 ITSAO2245-14
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH1681 Artemisia carvifolia 青蒿 TCMH1681 KU555619
TCMH451 Rehmannia glutinosa 地黄 TCMH451 ITSAH4578-14
TCMH1966 Rehmannia glutinosa 熟地黄 TCMH1966 ITSAH4578-14
TCMH273 Fritillaria cirrhosa 川贝母 TCMH273 ITSAP3764-14
TCMH449 Cortex lycii radicis 地骨皮 TCMH449
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT143 CA3 Carbonic anhydrase III Lyase P07451
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT186 MAOB Monoamine oxidase B Oxidoreductase P27338
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT248 CXCL8 Interleukin-8 Unclassified P10145
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT287 TAS2R31 Taste receptor type 2 member 31 GPCR P59538
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT39 PDE5A Phosphodiesterase 5A Hydrolase O76074
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT598 TOP1 DNA topoisomerase I Isomerase P11387
TCMT601 F2 Thrombin Unclassified P00734
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT615 SENP8 Sentrin-specific protease 8 Protease Q96LD8
TCMT616 SENP7 Sentrin-specific protease 7 Protease Q9BQF6
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT632 PNP Purine nucleoside phosphorylase Transferase P00491
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT643 ADRA1A Alpha-1a adrenergic receptor GPCR P35348
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT853 SIGMAR1 Sigma opioid receptor Unclassified Q99720
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1230 Human herpesvirus 5
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1283 Human enterovirus 71
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1293 Vaccinia virus
TCMT1294 Human parainfluenza virus 3
TCMT1305 Salmonella enteritidis
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1385 Candida shehatae
TCMT1390 Human herpesvirus 2 strain G
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1460 Mycobacterium intracellulare
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA1A, AKR1B1, APP, CDC25B, CSNK2A1, CXCL8, CYP1B1, DRD2, DRD3, EGFR, ESR1, ESRRA, F2, F3, FABP3, FLT3, HSPA1A, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, NUAK1, PDE5A, PIM1, PTGS1, PTGS2, SMAD3, SRC, TEK, XDH 12.7249
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA1A, AKR1B1, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F10, F2, F3, FLT3, GPR35, GRM1, HCAR2, HSPA1A, HTR2A, HTR2B, HTR6, INSR, KDR, MET, MMP12, MMP9, PDE5A, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 12.7221
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 12.7221
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA1A, AKR1B1, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F10, F2, F3, FLT3, GPR35, GRM1, HCAR2, HSPA1A, HTR2A, HTR2B, HTR6, INSR, KDR, MET, MMP12, MMP9, PDE5A, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 12.7221
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRA1A, AKR1B1, APP, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, DRD3, EGFR, ESR1, F10, F2, F3, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HCAR2, HSD17B1, HSPA1A, HTR1A, HTR2A, HTR2B, HTR7, INSR, KDR, MAOB, MET, PPARA, PTGS1, PTGS2, SLC1A1, SMAD3, SRC, TEK, XDH 12.0881
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA1A, AKR1B1, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CXCL8, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F10, F2, F3, FLT3, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PDE5A, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 11.9665
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 11.9665
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA1A, AKR1B1, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CXCL8, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F10, F2, F3, FLT3, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PDE5A, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 11.7971
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APP, AXL, CA3, CA9, CSNK2A1, CXCL8, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, ESR1, ESRRA, FABP3, GRIK5, GRM5, HTR5A, IGF1R, INSR, MAOB, MMP2, MMP9, PPARA, PTGS2, RORC, SRC, TEK 11.0062
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA1A, AKR1B1, APP, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FLT3, GPR35, GRIK5, GRM1, GRM5, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, PDE5A, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, XDH 10.5074
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA1A, AKR1B1, APP, AXL, CYP1B1, DRD2, EGFR, F10, F2, F3, FLT3, GPR35, GRM1, HSPA1A, HTR2A, HTR2B, HTR6, INSR, KDR, MET, PDE5A, PTGS2, PTPN1, SRC, TEK, XDH 10.5056
[BP] GO:0042221 response to chemical ADRA1A, AKR1B1, ALPL, APP, AXL, CA2, CA3, CA9, CSNK2A1, CXCL8, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, HSPA1A, HTR2A, HTR2B, HTR5A, IGF1R, INSR, KDR, MAOB, MMP2, MMP9, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TOP1 10.4486
[BP] GO:0010033 response to organic substance ADRA1A, AKR1B1, ALPL, APP, AXL, CA2, CA3, CA9, CSNK2A1, CXCL8, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, HSPA1A, HTR5A, IGF1R, INSR, KDR, MAOB, MMP2, PPARA, PTGS2, RORC, SMAD3, SRC, TEK 10.4486
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, ADRA1A, APP, CA2, CA7, DRD1, DRD2, DRD3, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2A, PTGS2 10.4047
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, ADRA1A, APP, CA2, CA7, DRD1, DRD2, DRD3, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2A, PTGS2 10.4047
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA1A, AKR1B1, APP, AURKB, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, DUSP3, EGFR, ESR1, F10, F2, F3, FLT3, GPR35, GRM1, HSPA1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PDE5A, PTGS2, PTPN1, SRC, TEK, XDH 10.1711
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA1A, AKR1B1, APP, AXL, CSNK2A1, CYP1B1, DRD2, DRD3, EGFR, F10, F2, F3, FLT3, GPR35, GRM1, HSPA1A, HTR2A, HTR2B, HTR6, INSR, KDR, MET, MMP12, MMP9, PDE5A, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 10.0389
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, DRD1, DRD2, EGFR, GRM1, GRM3, GRM5, GRM8, HTR2A, PTGS2 9.927
[BP] GO:0009719 response to endogenous stimulus ADRA1A, AKR1B1, ALPL, APP, CA2, CA9, CSNK2A1, CXCL8, CYP1A2, DRD1, EGFR, ESR1, ESRRA, FABP3, FLT3, GRM5, HTR5A, IGF1R, INSR, MAOB, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK 9.68687
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRA1A, AKR1B1, APP, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, FLT3, GPR35, GRIK5, GRM1, GRM5, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, PDE5A, PIM1, PPARA, PTGS2, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, XDH 9.59211
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, AOX1, APP, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, FABP3, FUT7, HSPA1A, HTR2B, PDE5A, PIM1, PPARA, PTGS1, PTGS2, XDH 9.42198
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA1A, APP, CDC25B, DRD1, DRD2, DRD3, DUSP3, EGFR, ESRRB, F2, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HTR2A, HTR2B, IGF1R, INSR, KDR, MMP9, NUAK1, PDE5A, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 9.28028
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA1A, APP, CDC25B, DRD1, DRD2, DRD3, DUSP3, EGFR, ESRRB, F2, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HTR2A, HTR2B, IGF1R, INSR, KDR, MMP9, NUAK1, PDE5A, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 9.19535
[BP] GO:0007193 None ADORA1, DRD2, DRD3, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR5A, HTR7 8.8733
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA1A, AKR1B1, APP, AXL, CSNK2A1, CXCL8, CYP1B1, DRD2, DRD3, EGFR, ESRRA, F10, F2, F3, FABP4, FLT3, GPR35, GRM1, HSPA1A, HTR2A, HTR2B, HTR6, INSR, KDR, MET, MMP12, MMP2, MMP9, PDE5A, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 8.77592
[BP] GO:0007187 None ADORA1, ADRA1A, DRD1, DRD2, DRD3, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR5A, HTR6, HTR7 8.7736
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA1A, AKR1B1, AKR1B10, ALOX5, ALPL, APP, AXL, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESRRB, F10, F2, F3, FABP4, GRM1, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR7, IGF1R, INSR, MET, MMP1, MMP12, MMP2, MMP9, PDE5A, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, TOP1 8.48623
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APP, AXL, CA2, CA7, CSNK2A1, CXCL8, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F10, F2, F3, GPR35, GRIK5, GRM5, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MAOB, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK 8.39548
[BP] GO:0007188 None ADORA1, ADRA1A, DRD1, DRD2, DRD3, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR5A, HTR7 8.35382
[BP] GO:0014070 response to organic cyclic compound ALPL, APP, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, ESR1, ESRRA, FLT3, HTR5A, MAOB, PTGS2, RORC, SRC, TEK 8.10347
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRA1A, AKR1B1, APP, AXL, CA1, CA2, CSNK2A1, CXCL8, CYP1B1, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MMP2, MMP9, NUAK1, PDE5A, PIM1, PPARA, PTPN1, RORC, SIGMAR1, SMAD3, SRC, TEK 8.06239
[BP] GO:0007215 None APP, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.94674
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA1A, APP, CDC25B, DRD1, DRD2, EGFR, ESRRB, F2, FABP3, FLT3, GRM1, GRM5, HTR2A, HTR2B, INSR, KDR, MMP9, PDE5A, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 7.94674
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA1A, APP, CDC25B, DRD1, DRD2, EGFR, ESRRB, F2, FABP3, FLT3, GRM1, GRM5, HTR2A, HTR2B, INSR, KDR, MMP9, PDE5A, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 7.94674
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD2, EGFR, ESR1, FABP3, FABP4, FUT7, HSD17B1, MET, PPARA, PTGS1, PTGS2 7.90225
[BP] GO:0048878 chemical homeostasis ADRA1A, AKR1B1, APP, CA12, CA2, CA7, DRD1, DRD2, DRD3, EGFR, ESR1, F2, FABP3, FABP4, GPR35, GRIK5, GRM1, GRM5, HTR2A, HTR2B, INSR, MET, SMAD3 7.71832
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, ALPL, APP, AURKB, AXL, CA2, CA3, CA6, CA9, CSNK2A1, CXCL8, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, EGFR, ESR1, ESRRA, F10, F2, F3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, IGF1R, INSR, KDR, MAOB, MMP12, MMP2, MMP9, NUAK1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP1 7.62015
[BP] GO:0042592 homeostatic process ADORA1, ADRA1A, AKR1B1, APP, AXL, CA12, CA2, CA7, DRD1, DRD2, DRD3, EGFR, ESR1, F2, FABP3, FABP4, FLT3, GPR35, GRIK5, GRM1, GRM5, HTR2A, HTR2B, INSR, MET, SMAD3, SRC 7.56069
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6 7.47378
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, CDC25B, CSNK2A1, DRD2, DRD3, EGFR, ESR1, F2, F3, FLT3, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MMP12, MMP2, MMP9, PIM1, PTGS2, TEK 7.47064
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, DRD3, FABP3, PPARA, SLC1A1 7.4629
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, ADRA1A, APP, CA2, CXCL8, DRD1, DRD2, DRD3, ESR1, F2, GPR35, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, INSR, SIGMAR1, SRC 7.3689
[BP] GO:0019369 arachidonic acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2 7.31198
[BP] GO:0003018 None ADORA1, ADRA1A, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7, PTGS2, SRC, TEK 7.27832
[BP] GO:0009725 response to hormone ADRA1A, AKR1B1, ALPL, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HTR5A, INSR, MAOB, PPARA, PTGS2, SRC, TEK 7.22651
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, ADRA1A, APP, AURKB, CDC25B, CSNK2A1, CXCL8, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F2, F3, FABP4, FLT3, GPR35, GRM1, GRM3, GRM5, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, MET, MMP9, NUAK1, PDE5A, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 7.21622
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD1, DRD2, DRD3, EGFR, GRIK5, HTR1A, INSR, MAOB, PTGS2, SLC1A1, SMAD3 7.20434
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRA1A, APP, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, F2, F3, FABP4, FLT3, GRM1, GRM3, GRM5, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, MMP9, NUAK1, PDE5A, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 6.9904
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APP, CXCL8, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 6.9476
[BP] GO:0097756 None ADORA1, ADRA1A, HTR1A, HTR2A, HTR2B, HTR7, PTGS2 6.82149
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA1A, APP, CDC25B, DRD1, DRD2, DUSP3, EGFR, ESRRB, F2, FABP4, FLT3, GRM1, GRM5, HTR2A, HTR2B, IGF1R, INSR, KDR, MMP9, PDE5A, PPARA, PTGS2, PTPN1, SRC, TEK, XDH 6.71014
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APP, CXCL8, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 6.70429
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2 6.69095
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA1A, APP, CDC25B, DRD2, EGFR, ESRRB, F2, FLT3, GRM1, GRM5, HTR2A, HTR2B, INSR, KDR, MMP9, PDE5A, PTGS2, PTPN1, SRC, TEK, XDH 6.67699
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA1A, APP, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, GRM1, GRM5, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MAOB, MET, MMP12, MMP9, PDE5A, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, XDH 6.62929
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRA1A, AKR1B1, APP, AURKB, AXL, CSNK2A1, CXCL8, CYP1B1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F10, F2, F3, FLT3, GPR35, GRM1, HSPA1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PDE5A, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 6.59848
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA1A, APP, AXL, CA2, CXCL8, CYP1B1, DRD2, DRD3, EGFR, ESRRB, F2, F3, HCAR2, HSPA1A, HTR2A, HTR2B, KDR, MET, MMP12, MMP9, PDE5A, PIM1, PTGS2, SLC1A1, SMAD3, SRC, TEK 6.56967
[BP] GO:0007210 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.56967
[BP] GO:0098664 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.56967
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APP, CXCL8, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 6.55814
[BP] GO:0042493 response to drug ADRA1A, AKR1B1, AXL, CA3, CA9, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, EGFR, FABP3, HTR2A, HTR2B, KDR, MAOB, PTGS2, SRC, TOP1 6.55699
[BP] GO:0006690 icosanoid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2 6.48644
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, DRD3, F2, FABP3, FLT3, HCAR2, HTR2A, HTR2B, PPARA, PTGS2, RORC, SRC, TEK 6.46541
[BP] GO:0050801 ion homeostasis ADRA1A, APP, CA12, CA2, CA7, DRD1, DRD2, DRD3, EGFR, ESR1, F2, FABP3, GPR35, GRM1, GRM5, HTR2A, HTR2B, SMAD3 6.39095
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, ESR1, HSD17B1 6.38979
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA1A, APP, DRD2, EGFR, FLT3, GRM1, HTR2A, HTR2B, INSR, KDR, PDE5A, PTPN1, SRC, TEK, XDH 6.38979
[BP] GO:0048583 regulation of response to stimulus ADORA1, ADRA1A, AKR1B1, APP, AURKB, AXL, CSNK2A1, CXCL8, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, F10, F2, F3, FABP4, FLT3, GPR35, GRM1, HSPA1A, HTR2A, HTR2B, HTR6, IGF1R, INSR, KDR, MET, MMP12, MMP2, MMP9, NUAK1, PDE5A, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 6.34384
[BP] GO:0030335 positive regulation of cell migration APP, CXCL8, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 6.34013
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA1A, APP, CDC25B, DRD2, EGFR, F2, FLT3, GRM1, GRM5, HTR2A, HTR2B, INSR, KDR, MMP9, PDE5A, PTGS2, PTPN1, SRC, TEK, XDH 6.33843
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA1A, APP, AURKB, CDC25B, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FLT3, GRM1, GRM5, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MAOB, MET, MMP12, MMP9, PDE5A, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, XDH 6.252
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, EGFR, HSPA1A, MAOB 6.21851
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADRA1A, APP, CDC25B, DRD1, DRD2, DUSP3, EGFR, F2, FABP4, FLT3, GRM1, GRM5, HTR2A, HTR2B, IGF1R, INSR, KDR, MMP9, PDE5A, PTGS2, PTPN1, SRC, TEK, XDH 6.21851
[BP] GO:0003013 None ADORA1, ADRA1A, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7, PTGS2, SRC, TEK 6.18893
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD17B1, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PDE5A, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SIGMAR1, SLC1A1, SMAD3, SRC, TEK, TOP1, XDH 6.18893
[BP] GO:0051049 regulation of transport ACHE, ADORA1, APP, AXL, CA2, CA7, CYP19A1, DRD1, DRD2, DRD3, EGFR, F2, GPR35, GRIK5, GRM5, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, INSR, MAOB, MMP12, MMP9, PPARA, PTGS2, PTPN1, SMAD3, SRC 6.17453
[BP] GO:2000147 positive regulation of cell motility APP, CXCL8, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 6.17453
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, DRD1, DRD2, DRD3, F2, HTR2A, HTR2B, KDR, SRC 6.13964
[BP] GO:0010035 response to inorganic substance AKR1B1, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, EGFR, FABP4, KDR, MAOB, MMP9, PTGS2, SRC 6.13101
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, DRD3, EGFR, F10, F3, INSR, MET, SRC, TEK, XDH 6.08194
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GRIK5, HCAR2, HSPA1A, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, PTGS2, PTPN1, SIGMAR1, SMAD3, SRC, TEK, XDH 6.07917
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GRIK5, HCAR2, HSPA1A, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SIGMAR1, SMAD3, SRC, TEK, XDH 6.06893
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD2, DRD3, FABP3, PPARA, SLC1A1 6.06496
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APP, CXCL8, CYP19A1, CYP1B1, DRD1, DRD2, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 6.05365
[BP] GO:0051272 positive regulation of cellular component movement APP, CXCL8, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 6.03979
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, ADRA1A, APP, CA2, CA7, DRD1, DRD2, EGFR, PTGS2 6.00761
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ADRA1A, APP, DRD2, DUSP3, EGFR, FLT3, GRM1, HTR2A, HTR2B, IGF1R, INSR, KDR, PDE5A, PTPN1, SRC, TEK, XDH 6.00761
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, DRD1, DRD2, DRD3, EGFR, F2, HCAR2, HTR2A, HTR2B, KDR, PTGS2, SRC 6.00085
[BP] GO:0033993 response to lipid ALPL, AXL, CA2, CA9, CSNK2A1, CXCL8, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HTR5A, MAOB, PTGS2, RORC, SRC 5.98636
[BP] GO:0045834 positive regulation of lipid metabolic process F2, FABP3, FLT3, HTR2A, HTR2B, PPARA, PTGS2, SRC, TEK 5.9582
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA1A, APP, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FLT3, GRM1, GRM5, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MAOB, MET, MMP12, MMP9, PDE5A, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, XDH 5.95034
[BP] GO:0097746 None ADORA1, ADRA1A, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7, PTGS2 5.9372
[BP] GO:0035296 None ADORA1, ADRA1A, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7, PTGS2 5.9372
[BP] GO:0098771 inorganic ion homeostasis ADRA1A, APP, CA12, CA2, CA7, DRD1, DRD2, DRD3, EGFR, ESR1, F2, GPR35, GRM1, GRM5, HTR2A, HTR2B, SMAD3 5.93068
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, APP, AURKB, AXL, CSNK2A1, CXCL8, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, GPR35, GRM3, GRM8, HSPA1A, HTR2A, HTR2B, IGF1R, KDR, MAOB, MET, MMP12, MMP9, PDE5A, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, XDH 5.92244
[BP] GO:0040017 positive regulation of locomotion APP, CXCL8, DRD1, EGFR, F10, F3, IGF1R, INSR, KDR, MET, MMP9, PTGS2, SMAD3, SRC, TEK 5.87352
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSPA1A, HTR1A, HTR2B, IGF1R, INSR, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PDE5A, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP1, XDH 5.82919
[BP] GO:0072507 divalent inorganic cation homeostasis ADRA1A, APP, DRD1, DRD2, DRD3, EGFR, ESR1, F2, GPR35, GRM1, GRM5, HTR2A, HTR2B, SMAD3 5.82858
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F2, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSPA1A, HTR1A, HTR2B, IGF1R, INSR, KDR, MAOB, MET, MMP1, MMP2, NUAK1, PDE5A, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP1, XDH 5.82512
[BP] GO:0050880 None ADORA1, ADRA1A, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7, PTGS2 5.72832
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA1A, APP, AURKB, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, GRM1, GRM5, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MMP12, MMP9, PDE5A, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, XDH 5.72832
[BP] GO:0007268 None DRD1, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR6, HTR7, SLC1A1 5.72458
[BP] GO:0098916 None DRD1, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR6, HTR7, SLC1A1 5.72458
[BP] GO:0043549 regulation of kinase activity ADORA1, APP, CDC25B, DRD2, DUSP3, EGFR, F2, FABP4, FLT3, GRM1, GRM5, HTR2A, HTR2B, IGF1R, INSR, PDE5A, PTPN1, SRC, TEK 5.71384
[BP] GO:0035150 None ADORA1, ADRA1A, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7, PTGS2 5.71348
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, APP, AXL, CXCL8, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, ESR1, FABP4, FLT3, GRIK5, GRM5, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, PTGS2, RORC, SMAD3, SRC 5.69452
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.63685
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6, CYP2D6 5.63685
[BP] GO:0099536 None DRD1, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR6, HTR7, SLC1A1 5.63685
[BP] GO:0099537 None DRD1, DRD2, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR6, HTR7, SLC1A1 5.63685
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ADRA1A, APP, CDC25B, CSNK2A1, DRD2, EGFR, ESR1, F2, F3, FLT3, GRM1, GRM5, HSPA1A, HTR2A, HTR2B, INSR, KDR, MMP9, PDE5A, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.62192
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GRIK5, HCAR2, HSPA1A, HTR2B, IGF1R, KDR, MMP9, PIM1, PTGS2, PTPN1, SIGMAR1, SMAD3, SRC, TEK, XDH 5.60224
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD2, EGFR, FABP3, FABP4, FUT7, MET, PPARA, PTGS1, PTGS2 5.60072
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA1A, CXCL8, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, HTR2A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SMAD3, SRC, XDH 5.57666
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA1A, CXCL8, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, GPR35, HSPA1A, HTR2A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SMAD3, SRC, XDH 5.55714
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CXCL8, CYP19A1, DRD1, DRD2, DRD3, EGFR, ESR1, F2, F3, FABP4, KDR, MET, MMP12, PPARA, PTGS2, SMAD3, TEK 5.52348
[BP] GO:0001676 long-chain fatty acid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2 5.50393
[BP] GO:0031399 regulation of protein modification process ADORA1, ADRA1A, APP, CDC25B, DRD1, DRD2, DUSP3, EGFR, F2, FABP4, FLT3, GRM1, GRM5, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MMP9, NUAK1, PDE5A, PTGS2, PTPN1, SRC, TEK, XDH 5.48992
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ADRA1A, APP, CDC25B, DRD2, EGFR, ESR1, F2, F3, FLT3, GRM1, GRM5, HSPA1A, HTR2A, HTR2B, INSR, KDR, MMP9, PDE5A, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.48025
[BP] GO:0006811 None ADRA1A, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD1, DRD2, DRD3, FABP3, GRIA2, GRIA4, GRIK5, HTR2A, HTR2B, PPARA, SLC1A1 5.48025
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, CA1, CSNK2A1, CXCL8, DRD2, EGFR, F2, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK 5.4576
[BP] GO:0006874 cellular calcium ion homeostasis ADRA1A, APP, DRD1, DRD2, DRD3, ESR1, F2, GPR35, GRM1, GRM5, HTR2A, HTR2B, SMAD3 5.45639
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ADRA1A, APP, AXL, CA2, CXCL8, CYP1B1, DRD2, DRD3, EGFR, ESR1, ESRRA, ESRRB, F2, F3, GPR35, GRM1, HCAR2, HSPA1A, HTR2A, HTR2B, INSR, KDR, MET, MMP12, MMP9, PDE5A, PIM1, PTGS2, SLC1A1, SMAD3, SRC, TEK, XDH 5.43402
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 5.42541
[BP] GO:0007267 None ADORA1, ADRA1A, DRD1, DRD2, DRD3, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR6, HTR7, SLC1A1, TEK 5.35648
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, CA2, CYP1A1, DRD1, DRD2, DRD3, EGFR, GRM1, HSPA1A, HTR2A, HTR2B, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK 5.35588
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, APP, AXL, CXCL8, CYP1A1, CYP1B1, DRD1, EGFR, ESR1, FABP4, FLT3, GRIK5, GRM5, IGF1R, INSR, KDR, MMP2, PTGS2, RORC, SMAD3, SRC 5.34524
[BP] GO:0055080 cation homeostasis ADRA1A, APP, CA2, CA7, DRD1, DRD2, DRD3, EGFR, ESR1, F2, GPR35, GRM1, GRM5, HTR2A, HTR2B, SMAD3 5.34497
[BP] GO:0055074 calcium ion homeostasis ADRA1A, APP, DRD1, DRD2, DRD3, ESR1, F2, GPR35, GRM1, GRM5, HTR2A, HTR2B, SMAD3 5.31626
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, DRD2, EGFR, F2, FLT3, GRM1, GRM5, HTR2A, HTR2B, INSR, PDE5A, PTPN1, SRC, TEK 5.31585
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 5.30505
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, CDC25B, DRD2, DUSP3, EGFR, F2, FABP4, FLT3, GRM1, GRM5, HTR2A, HTR2B, IGF1R, INSR, PDE5A, PTPN1, SRC, TEK 5.28601
[BP] GO:0072503 cellular divalent inorganic cation homeostasis ADRA1A, APP, DRD1, DRD2, DRD3, ESR1, F2, GPR35, GRM1, GRM5, HTR2A, HTR2B, SMAD3 5.26195
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, PTGS1, PTGS2 5.22693
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, SRC, TEK 5.22693
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, APP, AURKB, AXL, CA3, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, FLT3, HSPA1A, HTR2B, IGF1R, INSR, KDR, MET, NUAK1, PDE5A, PIM1, PTGS2, PTPN1, SRC, TEK, TOP1, XDH 5.22334
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 5.16596
[BP] GO:0030003 cellular cation homeostasis ADRA1A, APP, CA2, CA7, DRD1, DRD2, DRD3, ESR1, F2, GPR35, GRM1, GRM5, HTR2A, HTR2B, SMAD3 5.14393
[BP] GO:0055082 cellular chemical homeostasis ADRA1A, APP, CA2, CA7, DRD1, DRD2, DRD3, ESR1, F2, GPR35, GRIK5, GRM1, GRM5, HTR2A, HTR2B, SMAD3 5.14086
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, APP, AURKB, AXL, CSNK2A1, CXCL8, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, FABP4, GPR35, GRM3, GRM8, HCAR2, HSPA1A, HTR2A, HTR2B, IGF1R, KDR, MAOB, MET, MMP12, MMP9, PDE5A, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, XDH 5.13239
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA1A, CXCL8, CYP19A1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, F2, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.13239
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, CYP3A4, PTGS1, RORC 5.12131
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, FLT3, GRM1, HTR2A, HTR2B, IGF1R, INSR, PDE5A, PTPN1, SRC 5.11615
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ADRA1A, APP, DRD2, DUSP3, EGFR, HTR2A, HTR2B, KDR, PTPN1, SRC, TEK 5.11615
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AXL, CXCL8, CYP1B1, DRD1, EGFR, ESR1, GRIK5, GRM5, IGF1R, INSR, MMP2, MMP9, PTGS2, RORC, SRC 5.07039
[BP] GO:0044093 positive regulation of molecular function ADORA1, ADRA1A, APP, AURKB, CDC25B, DRD2, EGFR, ESR1, ESR2, F2, F3, FLT3, GRM1, GRM5, HSPA1A, HTR2A, HTR2B, INSR, MET, MMP9, PDE5A, PTPN1, SMAD3, SRC, TEK, XDH 5.06453
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK 5.05091
[BP] GO:0006873 cellular ion homeostasis ADRA1A, APP, CA2, CA7, DRD1, DRD2, DRD3, ESR1, F2, GPR35, GRM1, GRM5, HTR2A, HTR2B, SMAD3 5.03131
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, CYP2D6, DRD2, DRD3, DUSP3, ESR1, FABP4, GPR35, GRM3, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC 5.02722
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, DRD2, DRD3, EGFR, ESR1, HTR7, PPARA, RORC, SRC, TOP1 4.97416
[BP] GO:0006939 None ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7 4.9705
[BP] GO:0051480 regulation of cytosolic calcium ion concentration ADRA1A, DRD1, DRD2, ESR1, F2, GPR35, GRM1, GRM5, HTR2A, HTR2B, SMAD3 4.96314
[BP] GO:0007154 None ADORA1, ADRA1A, AXL, DRD1, DRD2, DRD3, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR6, HTR7, PTGS2, SLC1A1, TEK 4.94022
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, HTR2B, IGF1R, KDR, MET, MMP9, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK 4.94022
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD2, EGFR, ESR1, HCAR2, HSD17B1, HTR1A, HTR2A 4.92965
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, DRD1, DRD2, DRD3, EGFR, F2, HCAR2, PTGS2 4.92748
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, DRD2, EGFR, F2, FLT3, GRM1, GRM5, HTR2A, HTR2B, INSR, PDE5A, PTPN1, SRC, TEK 4.90415
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, ADRA1A, APP, AURKB, CDC25B, DRD2, EGFR, ESR1, F2, F3, FLT3, GRM1, GRM5, HSPA1A, HTR2A, HTR2B, INSR, PDE5A, PTPN1, SMAD3, SRC, TEK, XDH 4.88646
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, APP, AURKB, AXL, CA3, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, FLT3, HSPA1A, HTR2B, IGF1R, INSR, KDR, MET, NUAK1, PDE5A, PIM1, PTGS2, PTPN1, SRC, TEK, TOP1, XDH 4.8597
[BP] GO:0044057 None ADORA1, ADORA3, ADRA1A, DRD2, DRD3, EGFR, GPR35, GRM1, HCAR2, HTR2A, PDE5A, PTGS2, SLC1A1, SMAD3 4.84115
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, CDC25B, DRD2, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HTR2A, HTR2B, IGF1R, INSR, PDE5A, PTPN1, SRC 4.82286
[BP] GO:0006631 fatty acid metabolic process ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, PPARA, PTGS1, PTGS2 4.82286
[BP] GO:0023052 None ADORA1, ADRA1A, DRD1, DRD2, DRD3, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR6, HTR7, SLC1A1, TEK 4.80747
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ADRA1A, APP, CDC25B, DRD2, EGFR, F2, FLT3, GRM1, GRM5, HTR2A, HTR2B, INSR, KDR, MMP9, PDE5A, PTGS2, PTPN1, SRC, TEK, XDH 4.80747
[BP] GO:0043269 regulation of ion transport ADORA1, APP, CA2, CA7, DRD1, DRD2, DRD3, F2, GPR35, GRM5, HTR1A, HTR2A, MAOB, MMP9, PTGS2 4.80747
[BP] GO:1900542 None DRD1, DRD2, DRD3, ESRRB, GRM3, GRM8, HTR2A, INSR, PDE5A, PPARA 4.80747
[BP] GO:0019932 second-messenger-mediated signaling ADRA1A, CXCL8, DRD1, DRD2, DRD3, EGFR, GRM5, HTR2B, HTR5A, KDR 4.79428
[BP] GO:0007200 None ADRA1A, DRD1, DRD2, ESR1, GRM5, HTR2A, HTR2B 4.75661
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD1, DRD2, DRD3, HTR1A, MAOB 4.71726
[BP] GO:0006140 None DRD1, DRD2, DRD3, ESRRB, GRM3, GRM8, HTR2A, INSR, PDE5A, PPARA 4.70259
[BP] GO:0080134 regulation of response to stress ADORA1, APP, CYP19A1, DRD2, DUSP3, EGFR, ESR1, F2, F3, FABP4, HSPA1A, IGF1R, MET, MMP12, MMP2, NUAK1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.69751
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, ADRA1A, AKR1B1, ALPL, APP, AXL, CA2, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESRRA, ESRRB, F2, FLT3, HTR5A, INSR, KDR, MAOB, MMP9, PIM1, PPARA, PTGS2, RORC, SIGMAR1, SMAD3, SRC, TEK 4.6675
[BP] GO:0042310 None ADRA1A, HTR1A, HTR2A, HTR2B, HTR7 4.65905
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 4.6468
[BP] GO:0055065 metal ion homeostasis ADRA1A, APP, DRD1, DRD2, DRD3, EGFR, ESR1, F2, GPR35, GRM1, GRM5, HTR2A, HTR2B, SMAD3 4.61906
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 4.59172
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, CDC25B, CSNK2A1, DRD1, EGFR, FLT3, HTR2B, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1 4.51349
[BP] GO:0043271 negative regulation of ion transport ADORA1, DRD2, DRD3, GPR35, HTR2A, MAOB, MMP9, PTGS2 4.49438
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, ADRA1A, CA2, CA7, DRD2 4.449
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ADRA1A, APP, DRD2, EGFR, HTR2A, HTR2B, KDR, SRC, TEK 4.449
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, CA3, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, KDR, MAOB, SRC 4.42569
[BP] GO:0007198 None HTR1A, HTR5A, HTR7 4.42569
[BP] GO:0006875 cellular metal ion homeostasis ADRA1A, APP, DRD1, DRD2, DRD3, ESR1, F2, GPR35, GRM1, GRM5, HTR2A, HTR2B, SMAD3 4.39699
[BP] GO:0010863 positive regulation of phospholipase C activity ADRA1A, EGFR, ESR1, HTR2A, HTR2B 4.38854
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.38854
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, HTR2B, IGF1R, KDR, MMP9, PIM1, PTGS2, PTPN1, SMAD3, SRC, TEK 4.38854
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, EGFR, FLT3, GRM1, HTR2A, HTR2B, INSR, PDE5A, PTPN1, SRC 4.37177
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, DRD1, DRD2, DRD3, EGFR, FABP3, FLT3, GRM5, IGF1R, INSR, MMP2, PPARA, PTGS2, SRC, TEK 4.35873
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, APP, AXL, CA2, CYP19A1, DRD1, DRD2, DRD3, EGFR, F2, HCAR2, HTR2B, INSR, MMP12, PTGS2, SMAD3, SRC 4.35756
[BP] GO:0008217 None ADORA1, ADRA1A, DRD2, DRD3, PPARA, PTGS1, PTGS2, SMAD3 4.33531
[BP] GO:0032502 developmental process ACHE, ADORA1, ADRA1A, AKR1B1, ALPL, APP, AURKB, AXL, CA2, CA9, CDC25B, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DUSP3, EGFR, ESR1, ESRRA, ESRRB, F2, FABP4, FLT3, FUT7, HTR2A, HTR2B, HTR5A, INSR, KDR, MAOB, MET, MMP2, MMP9, PIM1, PPARA, PTGS2, RORC, SIGMAR1, SMAD3, SRC, TEK 4.33531
[BP] GO:0048513 animal organ development ACHE, ADRA1A, AXL, CA2, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, ESRRB, FLT3, INSR, KDR, PPARA, SMAD3, SRC, TEK 4.33398
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD1, DRD2, DRD3, HTR1A, MAOB 4.31153
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, DRD1, DRD2, HTR2A, PTGS2 4.30894
[BP] GO:0050795 None ADORA1, DRD2, DRD3, HTR1A, HTR2A, HTR2B 4.30894
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, APP, AURKB, AXL, CA2, CA9, CXCL8, CYP1A1, CYP1A2, CYP1B1, DRD1, EGFR, ESR1, FABP4, FLT3, GRIK5, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, PTGS2, PTPN1, RORC, SMAD3, SRC 4.28157
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F10, F3, INSR, MET, SRC, TEK 4.28157
[BP] GO:0021885 forebrain cell migration AXL, DRD1, DRD2, EGFR, HTR6 4.27967
[BP] GO:0050890 None ADORA1, APP, DRD1, DRD2, DRD3, EGFR, GRM5, HTR2A, INSR, PTGS2 4.27449
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, AXL, CA3, CYP1B1, EGFR, HSPA1A, MMP9, PTGS1, PTGS2, SRC 4.26484
[BP] GO:1900274 regulation of phospholipase C activity ADRA1A, EGFR, ESR1, HTR2A, HTR2B 4.22153
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, EGFR 4.20649
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, APP, AURKB, AXL, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, F10, F2, F3, FLT3, FUT7, HSPA1A, HTR1A, HTR2B, IGF1R, INSR, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PDE5A, PIM1, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP1, XDH 4.19867
[BP] GO:0019725 cellular homeostasis ADRA1A, APP, CA2, CA7, DRD1, DRD2, DRD3, ESR1, F2, GPR35, GRIK5, GRM1, GRM5, HTR2A, HTR2B, SMAD3 4.19378
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, DRD2, EGFR, ESR1, F2, FABP4, HSPA1A, MMP12, MMP2, PPARA, PTGS2, PTPN1, SMAD3, SRC, TEK 4.18986
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRA1A, APP, AURKB, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MAOB, MET, MMP12, MMP9, NUAK1, PDE5A, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP1, XDH 4.18986
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1 4.1875
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, FABP3, FABP4, FUT7, HSPA1A, MAOB, MMP1, MMP12, MMP2, MMP9, PDE5A, SRC, XDH 4.1841
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APP, CYP1A1, CYP1B1, DRD1, EGFR, ESR1, FLT3, PTGS2, RORC, SRC 4.18162
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, HTR2A, INSR, MET, SMAD3, SRC 4.17711
[BP] GO:0032225 None DRD1, DRD2, DRD3, PTGS2 4.17711
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, DRD2, EGFR, FLT3, GRM1, GRM5, HTR2A, HTR2B, INSR, PDE5A, PTPN1, SRC 4.16359
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, HSD17B1, MAOB, PTGS1, PTGS2, XDH 4.15362
[BP] GO:1902532 negative regulation of intracellular signal transduction ADRA1A, DRD2, DRD3, DUSP3, ESR1, HSPA1A, IGF1R, MET, MMP9, PTGS2, PTPN1, SRC, XDH 4.13859
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ADRA1A, APP, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, ESR1, F2, F3, FABP4, FLT3, GRM1, GRM5, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MMP9, NUAK1, PDE5A, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 4.10848
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, SRC, TEK 4.03861
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, APP, AURKB, AXL, CA1, CA12, CA2, CA7, CA9, CDC25B, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD17B1, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PDE5A, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SIGMAR1, SLC1A1, SMAD3, SRC, TEK, TOP1, XDH 4.02361
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, DRD1, DRD2, DRD3, EGFR, FABP3, FLT3, GRM5, IGF1R, INSR, MMP2, PPARA, PTGS2, SRC, TEK 3.96928
[BP] GO:0007610 None APP, DRD1, DRD2, DRD3, EGFR, GRM1, GRM5, HTR1A, HTR2A, HTR2B, INSR, PPARA, PTGS2 3.937
[BP] GO:0003008 None ADORA1, ADRA1A, AKR1B1, APP, CYP1B1, DRD1, DRD2, DRD3, EGFR, GRM1, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR7, INSR, PDE5A, PTGS2, SRC, TEK 3.937
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, DRD2, F2, MMP12, PPARA, SMAD3, TEK 3.93471
[BP] GO:0007611 None APP, DRD1, DRD2, DRD3, EGFR, GRM5, HTR2A, INSR, PTGS2 3.88194
[BP] GO:0016477 cell migration AXL, CXCL8, CYP1B1, DRD1, DRD2, EGFR, F2, FUT7, HTR2B, HTR6, KDR, MMP1, MMP12, MMP9, SRC, TEK 3.88187
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, RORC, SRC 3.86662
[BP] GO:0006584 None AKR1B1, DRD1, DRD2, DRD3, MAOB 3.86662
[BP] GO:0009712 None AKR1B1, DRD1, DRD2, DRD3, MAOB 3.86662
[BP] GO:0018958 None AKR1B1, DRD1, DRD2, DRD3, HTR1A, MAOB 3.85001
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP2D6, CYP3A4 3.80764
[BP] GO:0009611 response to wounding ACHE, ADORA3, CYP1A1, DRD2, EGFR, F2, PPARA, SMAD3 3.79841
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, EGFR 3.79622
[BP] GO:0048148 None DRD1, DRD2, DRD3, HTR2A 3.78998
[BP] GO:0009891 positive regulation of biosynthetic process APP, AURKB, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, FABP3, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MMP12, PPARA, PTGS2, RORC, SMAD3, SRC 3.76573
[BP] GO:0007204 positive regulation of cytosolic calcium ion concentration ADRA1A, DRD1, DRD2, ESR1, F2, GPR35, GRM1, HTR2A, HTR2B 3.70818
[BP] GO:0010038 response to metal ion APP, CA2, CYP1A1, CYP1A2, DRD2, EGFR, FABP4, MAOB, MMP9, PTGS2 3.70794
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1 3.70225
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ADRA1A, APP, AURKB, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MAOB, MET, MMP12, MMP9, NUAK1, PDE5A, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, XDH 3.69999
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 3.69449
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.69054
[BP] GO:0050789 regulation of biological process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, APP, AURKB, AXL, CA1, CA2, CA7, CA9, CDC25B, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PDE5A, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SIGMAR1, SLC1A1, SMAD3, SRC, TEK, TOP1, XDH 3.68096
[BP] GO:0042391 None ADORA1, ADRA1A, APP, DRD1, GPR35, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC 3.68059
[BP] GO:0010518 positive regulation of phospholipase activity ADRA1A, EGFR, ESR1, HTR2A, HTR2B 3.60665
[BP] GO:0009820 alkaloid metabolic process CYP1A2, CYP2D6, CYP3A4 3.59169
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, CYP19A1, DRD2, DRD3, EGFR, GRIK5, HCAR2, HTR1A, HTR2A, HTR2B, MAOB, MMP12, SRC 3.57946
[BP] GO:0007623 circadian rhythm DRD2, DRD3, EGFR, HTR7, PPARA, RORC, TOP1 3.57876
[BP] GO:0007612 None APP, DRD1, DRD2, DRD3, GRM5, INSR, PTGS2 3.57876
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APP, CXCL8, DRD1, EGFR, ESR1, FLT3, GRM5, IGF1R, INSR, MMP2, PTGS2, SMAD3, SRC 3.57776
[BP] GO:0001666 response to hypoxia ADORA1, CYP1A1, DRD2, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK 3.57776
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SRC, TEK 3.55972
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, APP, AURKB, AXL, CA1, CA2, CA7, CA9, CDC25B, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PDE5A, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SIGMAR1, SMAD3, SRC, TEK, XDH 3.54669
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, DUSP3, EGFR, FLT3, GRM1, HTR2A, HTR2B, IGF1R, INSR, PDE5A, PTPN1, SRC 3.52715
[BP] GO:0051588 None DRD1, DRD2, DRD3, GRIK5, HTR1A, MAOB 3.52665
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, F2, INSR, PTGS2, SMAD3, XDH 3.52665
[BP] GO:0007202 None ADRA1A, EGFR, HTR2A, HTR2B 3.49892
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1, MAOB 3.49892
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ADRA1A, APP, AURKB, CA9, CDC25B, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HSPA1A, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MAOB, MET, MMP12, MMP9, NUAK1, PDE5A, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, XDH 3.4892
[BP] GO:0036293 response to decreased oxygen levels ADORA1, CYP1A1, DRD2, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK 3.48864
[BP] GO:0040011 locomotion AXL, CXCL8, CYP1B1, DRD1, DRD2, EGFR, F2, FUT7, HTR2B, HTR6, KDR, MET, MMP1, MMP12, MMP9, SRC, TEK 3.4409
[BP] GO:0050927 None CXCL8, F3, KDR, SMAD3 3.43028
[BP] GO:0051940 None DRD1, DRD2, DRD3 3.42366
[BP] GO:0050665 hydrogen peroxide biosynthetic process CYP1A1, CYP1A2, MAOB 3.42366
[BP] GO:0051584 None DRD1, DRD2, DRD3 3.42366
[BP] GO:0048870 cell motility AXL, CXCL8, CYP1B1, DRD1, DRD2, EGFR, F2, FUT7, HTR2B, HTR6, KDR, MMP1, MMP12, MMP9, SRC, TEK 3.42366
[BP] GO:0090087 None ACHE, ADORA1, APP, CA2, DRD2, DRD3, EGFR, F2, HCAR2, HTR2B, MMP12, PTGS2, PTPN1, SMAD3, SRC 3.41562
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, GRM5, IGF1R, INSR, PPARA, PTGS2, SRC, TEK 3.41486
[BP] GO:0051246 regulation of protein metabolic process ADORA1, ADRA1A, APP, CDC25B, CSNK2A1, DRD1, DRD2, DUSP3, EGFR, ESR1, F2, F3, FABP4, FLT3, GRM1, GRM5, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MMP9, NUAK1, PDE5A, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 3.41147
[BP] GO:0031623 None ACHE, CXCL8, DRD2, DRD3, HTR2B 3.39846
[BP] GO:0032922 None DRD2, DRD3, PPARA, RORC, TOP1 3.39846
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, EGFR, FLT3, GRM1, HTR2A, HTR2B, INSR, PDE5A, PTPN1, SRC 3.39838
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APP, AURKB, CSNK2A1, CYP2D6, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, F2, FABP4, GRM3, GRM8, HCAR2, HSPA1A, HTR2B, IGF1R, KDR, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, XDH 3.39134
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, CDC25B, CSNK2A1, DRD1, EGFR, FLT3, HTR2B, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1 3.38693
[BP] GO:0050926 None CXCL8, F3, KDR, SMAD3 3.37937
[BP] GO:0035235 None APP, GRIA2, GRIA4, GRIK5 3.37937
[BP] GO:0035556 intracellular signal transduction ADRA1A, AKR1B1, AXL, CXCL8, CYP1B1, DRD1, DRD2, DRD3, EGFR, GRM5, HTR2A, HTR2B, HTR5A, IGF1R, INSR, KDR, MET, NUAK1, PTPN1, SRC, TEK 3.36426
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, CYP19A1, DRD1, DRD2, DRD3, F2, PPARA, SMAD3, TEK 3.36224
[BP] GO:0032103 positive regulation of response to external stimulus CXCL8, EGFR, F2, F3, FABP4, KDR, MET, PTGS2, SMAD3 3.36224
[BP] GO:1903522 None ADORA1, ADORA3, ADRA1A, DRD2, EGFR, HTR2A, PDE5A, PTGS2, SLC1A1 3.29044
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.28287
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.28287
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.28287
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.28287
[BP] GO:0071073 None FABP3, HTR2A, HTR2B 3.27997
[BP] GO:0051046 None ACHE, ADORA1, CYP19A1, DRD2, DRD3, EGFR, GRIK5, HCAR2, HTR1A, HTR2A, HTR2B, MAOB, MMP12, SRC 3.27997
[BP] GO:0010517 regulation of phospholipase activity ADRA1A, EGFR, ESR1, HTR2A, HTR2B 3.27258
[BP] GO:0042417 None DRD1, DRD2, DRD3, MAOB 3.26636
[BP] GO:0009968 negative regulation of signal transduction ADRA1A, CXCL8, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, HSPA1A, IGF1R, MET, MMP12, MMP9, PTGS2, PTPN1, SMAD3, SRC, XDH 3.24829
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, DRD2, MMP2, PPARA, PTGS2, SMAD3, SRC, TEK 3.23423
[BP] GO:0045787 positive regulation of cell cycle APP, AURKB, CDC25B, CYP1A1, DRD2, DRD3, DUSP3, EGFR, INSR, SRC 3.21865
[BP] GO:0060193 positive regulation of lipase activity ADRA1A, EGFR, ESR1, HTR2A, HTR2B 3.17708
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, ADRA1A, APP, AURKB, CA9, CDC25B, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HSPA1A, HTR1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MAOB, MET, MMP12, MMP9, NUAK1, PDE5A, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, XDH 3.16164
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR, MAOB 3.15519
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5 3.14457
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.14457
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 3.14005
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, DRD2, DRD3, EGFR, HCAR2, HTR2B, MMP12, SRC 3.12191
[BP] GO:0045744 None CXCL8, DRD2, DRD3, MET 3.10516
[BP] GO:0001659 None ADORA1, DRD1, DRD2, HTR2A 3.10516
[BP] GO:0050730 None ADORA1, APP, EGFR, FLT3, GRM5, HTR2A, PTPN1, SRC 3.09899
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 3.08164
[BP] GO:0050727 regulation of inflammatory response ADORA1, CYP19A1, EGFR, ESR1, F2, FABP4, PPARA, PTGS2, SMAD3, TEK 3.07127
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CSNK2A1, DRD1, EGFR, F10, F2, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK, TOP1 3.07127
[BP] GO:0022029 None DRD1, DRD2, EGFR, HTR6 3.05581
[BP] GO:2000377 regulation of reactive oxygen species metabolic process CYP1B1, EGFR, F2, INSR, PTGS2, SMAD3, XDH 3.05278
[BP] GO:0032787 None ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, FABP3, PPARA, PTGS1, PTGS2 3.04593
[BP] GO:0051222 positive regulation of protein transport ACHE, APP, DRD2, EGFR, F2, HCAR2, HTR2B, MMP12, PTGS2, SMAD3, SRC 3.03031
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK 3.02844
[BP] GO:0002031 None DRD2, DRD3, HTR2B 3.02664
[BP] GO:0042737 drug catabolic process ACHE, CYP1A2, CYP2A6, CYP2D6, CYP3A4, MAOB 3.02332
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APP, DRD1, EGFR, GRM5, IGF1R, INSR, MMP2, PTGS2, SRC 3.01411
[BP] GO:0051234 None ACHE, ADORA1, ADRA1A, ALOX5, APP, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CXCL8, DRD1, DRD2, DRD3, EGFR, F10, F2, FABP3, GRIA2, GRIA4, GRIK5, HSPA1A, HTR2A, HTR2B, MMP12, MMP9, PPARA, SIGMAR1, SLC1A1, SRC, XDH 3.01395
[BP] GO:0090218 positive regulation of lipid kinase activity F2, FLT3, SRC, TEK 3.01395
[BP] GO:0010907 None ESRRB, INSR, PPARA, SRC 3.01395
[BP] GO:0045907 None ADRA1A, EGFR, HTR2A, PTGS2 3.01395
[BP] GO:0045913 None ESRRB, HTR2A, INSR, PPARA, SRC 3.01141
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, F2, PPARA, SMAD3, TEK 3.00968
[BP] GO:1903524 None ADRA1A, EGFR, HTR2A, PTGS2, SLC1A1 2.95316
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, DRD1, DRD2, HTR2A, MET 2.95049
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AURKB, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, HTR2A, HTR2B, IGF1R, INSR, MET, MMP12, PPARA, PTGS2, RORC, SMAD3, SRC 2.94233
[BP] GO:1900543 None DRD2, DRD3, GRM3, GRM8, PPARA 2.92976
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2A6, CYP3A4 2.9246
[BP] GO:0070989 oxidative demethylation CYP1A2, CYP2D6, CYP3A4 2.9246
[BP] GO:0009115 None AOX1, XDH 2.92224
[BP] GO:0045980 None DRD2, DRD3, GRM3, GRM8, PPARA 2.91105
[BP] GO:0006810 None ACHE, ADORA1, ADRA1A, ALOX5, APP, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CXCL8, DRD1, DRD2, DRD3, F10, F2, FABP3, GRIA2, GRIA4, GRIK5, HSPA1A, HTR2A, HTR2B, MMP12, MMP9, PPARA, SIGMAR1, SLC1A1, SRC, XDH 2.87209
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, ADRA1A, APP, CXCL8, CYP1B1, DRD2, FABP3, HSPA1A, PDE5A, PTGS2, SMAD3, XDH 2.86935
[BP] GO:0032355 response to estradiol CYP1A2, EGFR, ESR1, ESRRA, HTR5A, PTGS2 2.84693
[BP] GO:0032467 None AURKB, CDC25B, DRD2, DRD3 2.83876
[BP] GO:0002793 None ACHE, ADORA1, DRD2, EGFR, HCAR2, HTR2B, MMP12, SRC 2.83528
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC, TEK 2.8304
[BP] GO:0060134 None DRD1, DRD2, DRD3 2.82938
[BP] GO:0032230 positive regulation of synaptic transmission, GABAergic ADRA1A, CA2, CA7 2.82938
[BP] GO:0051952 None ADORA1, DRD1, DRD2, DRD3, HTR2A 2.80848
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9, PTGS2 2.80848
[BP] GO:1904951 positive regulation of establishment of protein localization ACHE, APP, DRD2, EGFR, F2, HCAR2, HTR2B, MMP12, PTGS2, SMAD3, SRC 2.80148
[BP] GO:0060078 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5 2.78303
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APP, DRD1, EGFR, GRM5, IGF1R, INSR, MMP2, PTGS2, SRC 2.76046
[BP] GO:0051179 None ACHE, ADORA1, ADRA1A, ALOX5, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CXCL8, DRD1, DRD2, DRD3, EGFR, ESR1, F10, F2, FABP3, GRIA2, GRIA4, GRIK5, HSPA1A, HTR2A, HTR2B, MMP12, MMP9, PPARA, SIGMAR1, SLC1A1, SRC, XDH 2.74786
[BP] GO:1900182 positive regulation of protein localization to nucleus APP, EGFR, F2, PTGS2, SMAD3, SRC 2.7469
[BP] GO:0003012 None ADORA1, ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7, PDE5A 2.74274
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.73965
[BP] GO:0051580 None DRD1, DRD2, DRD3 2.73965
[BP] GO:0051967 None ADORA1, DRD2, HTR2A 2.73965
[BP] GO:0051336 regulation of hydrolase activity ADRA1A, APP, CSNK2A1, DRD2, EGFR, ESR1, F3, HSPA1A, HTR2A, HTR2B, MMP9, NUAK1, PTGS2, PTPN1, SMAD3, SRC, XDH 2.73166
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 2.72638
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process APP, AURKB, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSPA1A, HTR2A, IGF1R, INSR, MET, MMP12, PPARA, PTPN1, RORC, SMAD3, SRC 2.68812
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, PTGS2, SMAD3 2.6833
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.6833
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 2.68276
[BP] GO:0001963 None DRD1, DRD2, DRD3 2.65235
[BP] GO:0045776 None ADORA1, DRD2, DRD3, PPARA 2.64542
[BP] GO:0050793 regulation of developmental process APP, AXL, CA2, CXCL8, CYP1B1, DRD2, DRD3, EGFR, ESR1, ESRRA, ESRRB, F2, F3, HTR2A, INSR, KDR, NUAK1, PDE5A, PIM1, PPARA, PTGS2, RORC, SMAD3, SRC, TEK, XDH 2.63804
[BP] GO:0051781 None AURKB, CDC25B, DRD2, DRD3, HTR2B 2.62189
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CXCL8, CYP1A1, CYP1A2, MAOB, PTGS2, SRC 2.61131
[BP] GO:0060191 regulation of lipase activity ADRA1A, EGFR, ESR1, HTR2A, HTR2B 2.60015
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, CDC25B, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSPA1A, HTR1A, HTR2B, IGF1R, INSR, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PDE5A, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP1, XDH 2.58922
[BP] GO:0030534 None APP, DRD1, DRD2, DRD3, HTR2A, PPARA 2.58764
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, F3, MMP9, PTGS2, SMAD3, SRC, XDH 2.5775
[BP] GO:0030818 None DRD2, DRD3, GRM3, GRM8 2.5775
[BP] GO:0071071 None FABP3, HTR2A, HTR2B 2.5775
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.5775
[BP] GO:1901361 None AOX1, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP3A4, HSPA1A, MAOB, PDE5A, XDH 2.57416
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, DRD1, EGFR, KDR, PTGS2, SRC 2.56745
[BP] GO:0030799 None DRD1, DRD2, DRD3, GRM3, GRM8, PDE5A 2.56108
[BP] GO:0051302 None AURKB, CDC25B, DRD2, DRD3, ESRRB, HTR2B 2.54603
[BP] GO:0090066 None ADORA1, ADRA1A, DRD1, EGFR, HTR1A, HTR2A, HTR2B, HTR7, PTGS2 2.53418
[BP] GO:0045931 positive regulation of mitotic cell cycle APP, CDC25B, CYP1A1, DRD3, DUSP3, INSR 2.5311
[BP] GO:2001023 None DRD1, DRD2, DRD3, HTR2A, MET 2.51988
[BP] GO:0030803 None DRD2, DRD3, GRM3, GRM8 2.51041
[BP] GO:0099566 None GRM1, GRM5 2.51037
[BP] GO:0009822 alkaloid catabolic process CYP2D6, CYP3A4 2.51037
[BP] GO:0046110 None AOX1, XDH 2.51037
[BP] GO:0060160 None DRD2, DRD3 2.51037
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.51037
[BP] GO:0019933 None ADRA1A, DRD1, DRD2, DRD3, HTR5A 2.48317
[BP] GO:0006928 movement of cell or subcellular component APP, AXL, CXCL8, CYP1B1, DRD1, DRD2, EGFR, F2, FUT7, HTR2B, HTR6, KDR, MMP1, MMP12, MMP9, PTGS2, SRC, TEK 2.48006
[BP] GO:0071248 cellular response to metal ion CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 2.4782
[BP] GO:0051223 None ACHE, APP, DRD2, DRD3, EGFR, F2, HCAR2, HTR2B, MMP12, PTGS2, PTPN1, SMAD3, SRC 2.45356
[BP] GO:0008542 None APP, DRD1, DRD2, DRD3 2.45028
[BP] GO:0030815 None DRD2, DRD3, GRM3, GRM8 2.45028
[BP] GO:0051094 positive regulation of developmental process APP, AXL, CA2, CXCL8, CYP1B1, DRD2, ESRRB, F3, HTR2A, INSR, KDR, PDE5A, PIM1, PTGS2, SMAD3, SRC, TEK 2.45028
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CXCL8, CYP1A1, CYP1A2, MAOB, PTGS2, SRC 2.44341
[BP] GO:0045821 None ESRRB, HTR2A, INSR 2.44341
[BP] GO:0014821 None DRD1, DRD2, HTR2B 2.44341
[BP] GO:0048545 response to steroid hormone ALPL, CA2, EGFR, FLT3, MAOB, PTGS2, SRC 2.4413
[BP] GO:0002682 regulation of immune system process ADORA1, APP, AXL, CA2, CXCL8, CYP19A1, DRD2, DUSP3, ESR1, ESRRA, F2, HCAR2, HSPA1A, MMP12, MMP2, PDE5A, PTPN1, SMAD3, SRC 2.4413
[BP] GO:0031324 negative regulation of cellular metabolic process APP, AURKB, CSNK2A1, CYP2D6, DRD2, DRD3, DUSP3, ESR1, ESR2, ESRRA, F2, FABP4, GRM3, GRM8, HSPA1A, HTR2B, IGF1R, MET, MMP12, MMP9, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, XDH 2.42397
[BP] GO:1900372 None DRD2, DRD3, GRM3, GRM8 2.42397
[BP] GO:0030809 None DRD2, DRD3, GRM3, GRM8 2.42397
[BP] GO:0043112 None ACHE, CXCL8, DRD2, DRD3, HTR2B 2.4097
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway HSPA1A, MMP9, PTGS2, PTPN1, SRC 2.4097
[BP] GO:0045766 positive regulation of angiogenesis CXCL8, CYP1B1, F3, KDR, PTGS2, TEK 2.39821
[BP] GO:0048167 None ADORA1, APP, DRD1, DRD2, GRM5, PTGS2 2.39821
[BP] GO:0030800 None DRD2, DRD3, GRM3, GRM8 2.39382
[BP] GO:0010906 None ESRRB, INSR, PPARA, RORC, SRC 2.39166
[BP] GO:0031960 response to corticosteroid ALPL, EGFR, FLT3, MAOB, PTGS2, SRC 2.38733
[BP] GO:0042053 None DRD1, HTR1A, MAOB 2.38733
[BP] GO:0045187 None ADORA1, DRD2, DRD3 2.38733
[BP] GO:0042069 None DRD1, HTR1A, MAOB 2.38733
[BP] GO:0051197 None ESRRB, HTR2A, INSR 2.38733
[BP] GO:0009894 regulation of catabolic process ADORA1, CSNK2A1, EGFR, ESRRB, HCAR2, HSPA1A, HTR2A, HTR2B, INSR, KDR, MET, PPARA, PTPN1, SMAD3 2.38027
[BP] GO:0014066 regulation of phosphatidylinositol 3-kinase signaling EGFR, F2, FLT3, KDR, TEK 2.37825
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, APP, AXL, CA2, CA3, CA9, CXCL8, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, EGFR, F2, HSPA1A, HTR1A, MMP2, MMP9, NUAK1, PPARA, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TEK 2.36926
[BP] GO:1901575 None ACHE, ADORA1, AKR1B10, AOX1, AURKB, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, FABP3, FABP4, FUT7, HSPA1A, MAOB, PDE5A, XDH 2.36371
[BP] GO:0042307 positive regulation of protein import into nucleus APP, EGFR, F2, PTGS2, SMAD3 2.36235
[BP] GO:0030817 None DRD1, DRD2, DRD3, GRM3, GRM8 2.36235
[BP] GO:0042752 None ADORA1, DRD2, DRD3, PPARA, RORC 2.36235
[BP] GO:0051726 regulation of cell cycle APP, AURKB, CDC25B, CSNK2A1, CXCL8, CYP1A1, DRD2, DRD3, DUSP3, EGFR, HSPA1A, INSR, PIM1, PTGS2, SMAD3, SRC 2.3454
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.34425
[BP] GO:0010676 None ESRRB, INSR, PPARA, SRC 2.34425
[BP] GO:0043550 regulation of lipid kinase activity F2, FLT3, SRC, TEK 2.34425
[BP] GO:0035813 None ADORA1, DRD2, DRD3 2.33125
[BP] GO:0051130 positive regulation of cellular component organization APP, AURKB, AXL, DRD2, DRD3, ESR1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, SMAD3, SRC, TEK 2.3302
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.3302
[BP] GO:1904591 positive regulation of protein import APP, EGFR, F2, PTGS2, SMAD3 2.3302
[BP] GO:0019935 None ADRA1A, DRD1, DRD2, DRD3, HTR5A 2.3302
[BP] GO:0007632 None APP, DRD1, DRD2, DRD3 2.3194
[BP] GO:0051051 negative regulation of transport ADORA1, APP, DRD2, DRD3, GPR35, HSPA1A, HTR2A, MAOB, MMP9, PTGS2 2.31774
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, MAOB, XDH 2.3058
[BP] GO:0072593 reactive oxygen species metabolic process CYP1A1, CYP1A2, CYP1B1, EGFR, MAOB 2.29459
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.29258
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.29258
[BP] GO:0050714 None ACHE, DRD2, EGFR, HCAR2, HTR2B, MMP12, SRC 2.2902
[BP] GO:2000116 regulation of cysteine-type endopeptidase activity CSNK2A1, F3, MMP9, PTGS2, SMAD3, SRC, XDH 2.28008
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.28008
[BP] GO:0051968 None DRD1, EGFR, PTGS2 2.28008
[BP] GO:0042749 None ADORA1, DRD2, DRD3 2.28008
[BP] GO:0070201 None ACHE, APP, DRD2, DRD3, EGFR, F2, HCAR2, HTR2B, MMP12, PTGS2, PTPN1, SMAD3, SRC 2.27817
[BP] GO:0006145 None AOX1, XDH 2.27426
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.27426
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.27426
[BP] GO:0008150 biological_process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD17B1, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PDE5A, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SIGMAR1, SLC1A1, SMAD3, SRC, TEK, TOP1, XDH 2.2662
[BP] GO:0007613 None DRD1, DRD2, HTR2A, INSR, PTGS2 2.25247
[BP] GO:0051194 None ESRRB, HTR2A, INSR 2.23093
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.23093
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.21948
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3 2.21948
[BP] GO:0071363 cellular response to growth factor stimulus APP, CXCL8, EGFR, INSR, KDR, SMAD3, SRC 2.19794
[BP] GO:0071241 cellular response to inorganic substance CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 2.18735
[BP] GO:0050678 None EGFR, F3, HTR2B, KDR, MMP12, SMAD3, TEK, XDH 2.1813
[BP] GO:0044062 None ADORA1, DRD2, DRD3 2.17809
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.17809
[BP] GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ADORA1, FLT3, GRM5, HTR2A, PTPN1, SRC 2.17682
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, ADRA1A, APP, AURKB, CA9, CDC25B, CSNK2A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP4, FLT3, GRM1, GRM5, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, MMP12, MMP9, NUAK1, PDE5A, PIM1, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP1, XDH 2.1724
[BP] GO:0070988 demethylation CYP1A1, CYP1A2, CYP2D6, CYP3A4 2.169
[BP] GO:0006109 regulation of carbohydrate metabolic process ESRRB, HTR2A, INSR, PPARA, RORC, SRC 2.16714
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 2.16714
[BP] GO:0050679 None EGFR, F3, HTR2B, KDR, MMP12, TEK 2.15518
[BP] GO:1904018 positive regulation of vasculature development CXCL8, CYP1B1, F3, KDR, PTGS2, TEK 2.15518
[BP] GO:0019229 None ADRA1A, EGFR, HTR2A, PTGS2 2.1445
[BP] GO:0051894 None KDR, SMAD3, TEK 2.13019
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1 2.13019
[BP] GO:0051282 None DRD1, DRD2, F2, HTR2A, HTR2B 2.12098
[BP] GO:0019722 calcium-mediated signaling CXCL8, EGFR, GRM5, HTR2B, KDR 2.12098
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD17B1 2.12057
[BP] GO:1901654 None AKR1B1, CA9, CSNK2A1, EGFR, MAOB, SRC 2.12057
[BP] GO:0007626 None APP, DRD1, DRD2, DRD3, GRM1, GRM5 2.10816
[BP] GO:0001503 ossification ALPL, EGFR, MMP2, MMP9, TEK 2.10619
[BP] GO:0051172 None APP, AURKB, CSNK2A1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, F2, FABP4, GRM3, GRM8, HSPA1A, IGF1R, MMP12, MMP9, PPARA, PTGS2, PTPN1, RORC, SMAD3, SRC, XDH 2.09539
[BP] GO:0044419 interspecies interaction between organisms AXL, EGFR, F2, HSPA1A, HTR2A, INSR, KDR, MET, MMP1, SMAD3, SRC, TOP1 2.08892
[BP] GO:0051098 regulation of binding APP, AURKB, CYP2D6, MET, MMP9, PPARA, SMAD3, SRC 2.08892
[BP] GO:0045932 None ADORA1, PDE5A, PTGS2 2.08892
[BP] GO:0048169 None APP, DRD2, GRM5 2.08892
[BP] GO:0021853 None DRD1, DRD2 2.08892
[BP] GO:0010641 None F3, SRC 2.08892
[BP] GO:0090325 None DRD2, DRD3 2.08892
[BP] GO:0007598 None F10, F3 2.08892
[BP] GO:1904936 None DRD1, DRD2 2.08892
[BP] GO:0042321 None ADORA1, DRD2 2.08892
[BP] GO:0010513 None HTR2A, HTR2B 2.08892
[BP] GO:0030814 None DRD1, DRD2, DRD3, GRM3, GRM8 2.08381
[BP] GO:0050920 regulation of chemotaxis CXCL8, CYP19A1, F3, KDR, MET, SMAD3 2.08349
[BP] GO:0034762 None APP, CA2, DRD1, DRD2, DRD3, F2, GPR35, GRM5, MMP9 2.07766
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process APP, AURKB, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, IGF1R, INSR, KDR, MET, MMP12, PPARA, RORC, SMAD3, SRC 2.05928
[BP] GO:0046889 None FABP3, HTR2A, HTR2B, PTGS2 2.05928
[BP] GO:0060402 None ADRA1A, DRD2, HTR2A, HTR2B 2.05928
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.04926
[BP] GO:1903393 None KDR, SMAD3, TEK 2.04926
[BP] GO:0001975 None DRD1, DRD2, DRD3 2.04926
[BP] GO:0045822 None ADORA1, ADRA1A, PDE5A 2.04926
[BP] GO:0009895 negative regulation of catabolic process ADORA1, EGFR, HCAR2, HTR2B, MET, PPARA, SMAD3 2.0476
[BP] GO:0046883 regulation of hormone secretion ADORA1, CYP19A1, DRD2, EGFR, HCAR2, HTR1A, HTR2A 2.0476
[BP] GO:0030802 None DRD1, DRD2, DRD3, GRM3, GRM8 2.04214
[BP] GO:0040008 regulation of growth APP, CSNK2A1, DRD2, DRD3, EGFR, ESR2, F2, HSPA1A, INSR, PIM1, SMAD3 2.04154
[BP] GO:0030574 collagen catabolic process MMP1, MMP12, MMP2, MMP9 2.04056
[BP] GO:0008283 cell proliferation ACHE, AURKB, CYP1A1, EGFR, ESR1, FLT3, HTR1A, MET, PIM1, SRC, TEK 2.0373
[BP] GO:0044248 cellular catabolic process ACHE, AKR1B10, AOX1, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2D6, CYP3A4, FABP3, FABP4, HSPA1A, MAOB, PDE5A, SRC, XDH 2.01901
[BP] GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling F2, FLT3, KDR, TEK 2.01714
[BP] GO:0010675 None ESRRB, INSR, PPARA, RORC, SRC 2.01328
[BP] GO:0007346 regulation of mitotic cell cycle APP, AURKB, CDC25B, CYP1A1, DRD3, DUSP3, EGFR, HSPA1A, INSR, PIM1, SMAD3 2.01264
[BP] GO:0010959 None ADORA1, DRD1, DRD2, DRD3, F2, GPR35, HTR2A, PTGS2 2.01089
[BP] GO:0045745 None DRD2, DRD3, F2 2.01043
[BP] GO:1904646 cellular response to amyloid-beta APP, GRM5, IGF1R 2.01043
[BP] GO:1903532 None ACHE, CYP19A1, DRD2, EGFR, HCAR2, HTR2B, MMP12, SRC 2.00553
[BP] GO:0002791 None ACHE, ADORA1, DRD2, DRD3, EGFR, HCAR2, HTR2B, MMP12, SRC 2.00234
[BP] GO:0050877 None ADORA1, APP, CYP1B1, DRD1, DRD2, DRD3, EGFR, GRM1, GRM5, GRM8, HTR2A, INSR, PTGS2 2.00188
[BP] GO:0006110 None ESRRB, HTR2A, INSR, PPARA 2.00053
[BP] GO:0015908 None DRD2, DRD3, FABP3, PPARA 2.00053
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRA1A, APP, AXL, CA4, DRD1, DRD2, DRD3, F10, F3, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, SIGMAR1, SLC1A1, TEK 9.64751
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ADRA1A, APP, AXL, CA2, CA4, CA9, DRD1, DRD2, DRD3, DUSP3, EGFR, F10, F2, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, PTGS2, SIGMAR1, SLC1A1, SRC, TEK 8.8599
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, ADRA1A, APP, AXL, DRD1, DRD2, DRD3, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, SIGMAR1, SLC1A1, TEK 7.94674
[CC] GO:0098590 plasma membrane region ADORA1, ADRA1A, CA2, CA4, CA9, DRD1, DRD2, EGFR, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2A, INSR, MET, PTGS2, SIGMAR1, SLC1A1, SRC, TEK 7.4629
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ADRA1A, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, DRD1, DRD2, DRD3, EGFR, ESR1, F10, F2, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, MMP2, PIM1, PTPN1, SLC1A1, SMAD3, SRC, TEK 6.83285
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ADRA1A, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, F10, F2, F3, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MAOB, MET, PTGS1, PTGS2, PTPN1, SIGMAR1, SLC1A1, SRC, TEK 5.68957
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ADRA1A, ALOX5, ALPL, APP, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, EGFR, ESR1, F10, F2, F3, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MAOB, MET, MMP2, PIM1, PTGS1, PTGS2, PTPN1, SIGMAR1, SLC1A1, SMAD3, SRC, TEK 5.03631
[CC] GO:0043005 None ADORA1, APP, CA2, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR2B, HTR5A, PTGS2, SRC 3.52031
[CC] GO:0014069 None ADORA1, DRD2, GRIK5, GRM1, GRM3, GRM5, SIGMAR1, SRC 3.51683
[CC] GO:0099572 None ADORA1, DRD2, GRIK5, GRM1, GRM3, GRM5, SIGMAR1, SRC 3.51683
[CC] GO:0042995 cell projection ADORA1, AKR1B1, APP, CA2, DRD1, DRD2, DRD3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR2B, HTR5A, HTR6, PTGS2, SRC, TEK 3.42366
[CC] GO:0097458 None ADORA1, APP, CA2, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HTR2A, HTR2B, HTR5A, INSR, PTGS1, PTGS2, SIGMAR1, SRC, TOP1 3.36989
[CC] GO:0044432 endoplasmic reticulum part APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, EGFR, F10, F2, FLT3, GRIA2, PTGS1, PTGS2, PTPN1, SIGMAR1 3.30648
[CC] GO:0120025 None ADORA1, AKR1B1, APP, CA2, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, HTR2A, HTR2B, HTR5A, HTR6, PTGS2, SRC, TEK 3.23729
[CC] GO:0045121 membrane raft ADRA1A, APP, EGFR, HTR2A, INSR, KDR, PTGS2, SRC, TEK 3.21288
[CC] GO:0098857 membrane microdomain ADRA1A, APP, EGFR, HTR2A, INSR, KDR, PTGS2, SRC, TEK 3.19048
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 3.17708
[CC] GO:0043197 None ADORA1, APP, DRD2, GRIA2, GRIA4, GRM3 2.95049
[CC] GO:0043235 receptor complex APP, EGFR, GRIA2, GRIA4, GRIK5, GRM1, IGF1R, INSR, SMAD3 2.93067
[CC] GO:0005901 caveola ADRA1A, HTR2A, INSR, PTGS2, SRC 2.92976
[CC] GO:0044309 None ADORA1, APP, DRD2, GRIA2, GRIA4, GRM3 2.92224
[CC] GO:0044456 None ACHE, ADORA1, APP, DRD2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SIGMAR1, SRC 2.91792
[CC] GO:0044463 None ADORA1, AKR1B1, APP, CA4, CA9, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM3, HTR2A, INSR, PTGS1, SIGMAR1, SRC 2.77913
[CC] GO:0120038 None ADORA1, AKR1B1, APP, CA4, CA9, DRD1, DRD2, GRIA2, GRIA4, GRIK5, GRM3, HTR2A, INSR, PTGS1, SIGMAR1, SRC 2.77913
[CC] GO:0098589 membrane region ADRA1A, APP, EGFR, HTR2A, INSR, KDR, PTGS2, SRC, TEK 2.65257
[CC] GO:0097060 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SIGMAR1 2.51988
[CC] GO:0044853 plasma membrane raft ADRA1A, HTR2A, INSR, PTGS2, SRC 2.48317
[CC] GO:0098794 None ADORA1, APP, DRD2, GRIA2, GRIA4, GRM3 2.42397
[CC] GO:0005789 endoplasmic reticulum membrane CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, EGFR, GRIA2, PTGS1, PTGS2, SIGMAR1 2.36371
[CC] GO:0031233 None CA4, F10, F3 2.33125
[CC] GO:0031224 None ACHE, ADORA1, ADORA3, ADRA1A, ALPL, APP, AXL, CA12, CA14, CA4, CA9, CYP3A4, DRD1, DRD2, DRD3, EGFR, ESR1, F10, F3, FLT3, FUT7, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MAOB, MET, SIGMAR1, SLC1A1, TEK 2.3088
[CC] GO:0043227 membrane-bounded organelle ACHE, ADORA1, ADRA1A, AKR1B1, AKR1B10, ALPL, AOX1, APP, AURKB, AXL, CA1, CA2, CA4, CA5A, CA5B, CA6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FABP3, FABP4, FLT3, FUT7, GRIA4, GRIK5, GRM1, GRM5, HSPA1A, HTR2A, HTR5A, IGF1R, INSR, KDR, MAOB, MMP12, MMP2, MMP9, NUAK1, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SIGMAR1, SLC1A1, SMAD3, SRC, TOP1, XDH 2.27939
[CC] GO:0005783 None ADORA1, APP, CA4, CYP19A1, CYP2D6, FLT3, GRIK5, HSPA1A, HTR5A, KDR, PTGS2, PTPN1, SIGMAR1, XDH 2.27634
[CC] GO:0044464 cell part ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA7, CA9, CDC25B, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD17B1, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MAOB, MET, MMP12, MMP2, MMP9, NUAK1, PDE5A, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SIGMAR1, SLC1A1, SMAD3, SRC, TEK, TOP1, XDH 2.08892
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, TEK 2.04214
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 18.4011
[MF] GO:0046914 transition metal ion binding ALOX5, AOX1, APP, CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PIM1, PPARA, PTPN1, RORC, SMAD3, XDH 16.1983
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA1A, AXL, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, PPARA, RORC, SIGMAR1, TEK 15.7639
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, AOX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, IGF1R, INSR, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PDE5A, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, TOP1, XDH 15.1433
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA1A, AXL, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, PPARA, RORC, SIGMAR1, TEK 14.1764
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA1A, AXL, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, PPARA, RORC, SIGMAR1, TEK 13.7901
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA1A, AXL, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F2, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, PPARA, RORC, SIGMAR1, SMAD3, TEK 13.779
[MF] GO:0030594 None DRD1, DRD2, DRD3, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 12.7221
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 11.7549
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRA1A, AXL, DRD1, DRD2, DRD3, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, SIGMAR1, TEK 11.2548
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRA1A, AXL, DRD1, DRD2, DRD3, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, SIGMAR1, TEK 11.2548
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AOX1, APP, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, ESR1, ESR2, ESRRA, ESRRB, F10, F2, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, MMP1, MMP12, MMP2, MMP9, NUAK1, PDE5A, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SMAD3, XDH 11.0028
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 10.3926
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4 9.7552
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, CYP3A4 8.35221
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP12, MMP2, MMP9, PPARA, PTPN1, RORC, SMAD3 8.08124
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, PTGS1, PTGS2, SRC 8.03601
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.88528
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, PTGS1, PTGS2, SRC 7.73585
[MF] GO:0070405 ammonium ion binding ACHE, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR5A, HTR7 7.67072
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DUSP3, EGFR, F10, F2, F3, FLT3, FUT7, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PDE5A, PIM1, PTGS1, PTGS2, PTPN1, SRC, TEK, TOP1, XDH 7.43293
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, EGFR, FLT3, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, SIGMAR1, SRC, TEK, TOP1 7.38633
[MF] GO:0005506 iron ion binding ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, XDH 7.15403
[MF] GO:0008227 None ADRA1A, DRD2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 7.15229
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.86669
[MF] GO:0043176 None HTR1A, HTR2A, HTR2B, HTR5A, HTR7 6.62929
[MF] GO:0051378 None HTR1A, HTR2A, HTR2B, HTR5A, HTR7 6.62929
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9 6.586
[MF] GO:0004993 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.56967
[MF] GO:0099589 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 6.56967
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6, CYP3A4 6.45409
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AOX1, APP, AURKB, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, F2, MMP1, MMP12, MMP2, MMP9, NUAK1, PDE5A, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SMAD3, XDH 6.22386
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, PTGS1, PTGS2 6.21851
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.17453
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, HSD17B1, MAOB, PTGS1, PTGS2, SRC, XDH 5.92696
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP2D6, CYP3A4 5.7563
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4 5.64402
[MF] GO:0004930 None ADORA1, ADORA3, ADRA1A, DRD1, DRD2, DRD3, GPR35, GRM1, GRM3, GRM5, GRM8, HCAR2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, SIGMAR1 5.57361
[MF] GO:0099528 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 5.51164
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, HSD17B1, MAOB, PTGS1, PTGS2, XDH 5.25295
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.92845
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.92845
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR2A, HTR2B, HTR5A, HTR7 4.79519
[MF] GO:0005496 steroid binding CYP3A4, ESR1, ESR2, ESRRA, ESRRB, HSD17B1, RORC 4.78939
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 4.73564
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.49093
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1 3.77708
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, EGFR, ESRRB, FLT3, HTR2A, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC 3.62225
[MF] GO:0008289 lipid binding AXL, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, HSD17B1, PPARA, RORC 3.61932
[MF] GO:0032403 protein complex binding ACHE, ADORA1, EGFR, ESRRB, FLT3, HTR2A, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, SMAD3, SRC 3.52031
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.27997
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.27997
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, MAOB, XDH 3.14005
[MF] GO:0097159 organic cyclic compound binding ADORA1, AOX1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD17B1, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, IGF1R, INSR, KDR, MAOB, MET, MMP12, NUAK1, PDE5A, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP1, XDH 3.10137
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1 2.99931
[MF] GO:0004952 None DRD1, DRD2, DRD3 2.9246
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.92224
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.92224
[MF] GO:0008389 None CYP2A13, CYP2A6 2.92224
[MF] GO:0035240 None DRD1, DRD2, DRD3 2.82938
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1 2.62899
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR 2.60015
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.5775
[MF] GO:0017171 serine hydrolase activity ACHE, F10, F2, F3, MMP1, MMP12, MMP2, MMP9 2.55859
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.51037
[MF] GO:0099583 None GRM1, GRM5 2.51037
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.38733
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.38733
[MF] GO:1901338 None DRD1, DRD2, DRD3 2.33125
[MF] GO:0043168 anion binding AOX1, APP, AURKB, AXL, CSNK2A1, EGFR, F10, F2, F3, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, NUAK1, PDE5A, PIM1, SLC1A1, SRC, TEK, TOP1, XDH 2.3258
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.27426
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.27426
[MF] GO:0004971 None GRIA2, GRIA4 2.27426
[MF] GO:0051425 None APP, INSR 2.27426
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.27426
[MF] GO:0003674 molecular_function ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, AKR1B10, ALOX5, ALPL, AOX1, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CSNK2A1, CXCL8, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, DRD1, DRD2, DRD3, DUSP3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F10, F2, F3, FABP3, FABP4, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSD17B1, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MAOB, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PDE5A, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SIGMAR1, SLC1A1, SMAD3, SRC, TEK, TOP1, XDH 2.25967
[MF] GO:1901363 heterocyclic compound binding ADORA1, AOX1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2D6, CYP3A4, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HSD17B1, HSPA1A, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, IGF1R, INSR, KDR, MAOB, MET, MMP12, NUAK1, PDE5A, PIM1, PPARA, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP1, XDH 2.21323
[MF] GO:0004252 None F10, F2, F3, MMP1, MMP12, MMP2, MMP9 2.17097
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.08892
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.08892
[MF] GO:0043559 insulin binding IGF1R, INSR 2.08892
[MF] GO:0005518 collagen binding ACHE, MMP12, MMP9, SMAD3 2.08279
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1 2.01328
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, F10, F2, F3, FLT3, IGF1R, INSR, KDR, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIM1, PTPN1, SRC, TEK, TOP1 2.00771


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GRIA2, GPR35, GRIK5, HTR2B, HTR1A, HTR2A, F2, HTR5A, ADRA1A, GRM1, GRM3, HTR6, GRM5, HTR7, ADORA3, GRM8, ADORA1, DRD1, DRD2, DRD3, GRIA4 17.4712
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA3, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 19.7282
Serotonergic synapse_Homo sapiens_hsa04726 APP, HTR6, HTR7, MAOB, CYP2D6, ALOX5, HTR2B, HTR1A, HTR2A, PTGS2, HTR5A, PTGS1 11.1998
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 8.5897
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 7.2768
Calcium signaling pathway_Homo sapiens_hsa04020 HTR6, GRM5, HTR7, HTR2B, HTR2A, DRD1, HTR5A, ADRA1A, GRM1, EGFR 6.6542
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, HTR2B, HTR2A, DRD1, DRD2, GRM1, EGFR 6.7486
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, ESR1, GRM1, EGFR, ESR2, HSPA1A 6.4657
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, GRM1, GRIA4 6.121
Bladder cancer_Homo sapiens_hsa05219 CXCL8, SRC, MMP1, MMP2, MMP9, EGFR 6.2588
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP2A6, CYP2A13, CYP2D6, CYP1A2, CYP1A1, CYP1B1, CYP3A4 6.1669
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, GRIA2, HTR6, ADORA1, HTR1A, DRD1, DRD2, PPARA, GRIA4 5.4331
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, PTGS2, CYP3A4 5.8925
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 5.4911
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, MAOB, CYP2D6, CYP1A2, AOX1, CYP3A4 5.0991
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, ESR1, EGFR, IGF1R 4.4516
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KDR, TEK, DRD2, MET, EGFR, IGF1R 4.3753
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, CXCL8, INSR, GRM8, GRM1, EGFR 4.4516
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, CXCL8, FLT3, MMP1, MMP2, PTGS2, MMP9, MET, EGFR, IGF1R 4.0423
Tryptophan metabolism_Homo sapiens_hsa00380 MAOB, CYP1A2, CYP1A1, AOX1, CYP1B1 5.0023
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2, MAOB, DRD1, DRD2 4.5791
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, ADORA1, PTGS2, PTGS1 4.3753
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, MAOB, DRD1, DRD2, DRD3, GRIA4 3.7395
Ras signaling pathway_Homo sapiens_hsa04014 HTR7, INSR, KDR, TEK, MET, EGFR, IGF1R 3.2905
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, CXCL8, MMP2, PIM1, F3 3.2332
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1, CYP3A4 4.0737
Metabolic pathways_Homo sapiens_hsa01100 MAOB, AKR1B1, PTGS2, CYP3A4, CYP19A1, PTGS1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, CYP1A2, CYP1A1, AOX1, ALPL, XDH 3.1083
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 2.9974
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, PTGS2, GRM1, GRIA4 3.2332
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, PTGS2, MMP9, MET, EGFR, CDC25B 2.7042
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, GRM1, EGFR, IGF1R 2.7587
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, MAOB, DRD1, GRIA4 2.8761
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, INSR, ADORA1, PDE5A, ADRA1A 2.335
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 CXCL8, SRC, MET, EGFR 2.8649
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, EGFR, IGF1R 2.0169
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, TEK, EGFR, IGF1R 2.2574
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 CXCL8, FLT3, MMP9, MET, IGF1R 2.2251
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 2.8539
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 INSR, KDR, TEK, MET, EGFR, IGF1R 1.8085
Hepatitis B_Homo sapiens_hsa05161 SMAD3, CXCL8, SRC, MMP9 1.8184
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 CXCL8, FLT3, KDR, MET, EGFR 1.6411
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR, PTGS2 1.9674
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1, IGF1R 1.9776
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 1.9285
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 1.8297
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC, ESR1, ESR2 1.8219
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET, EGFR 1.8914
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, GRM1 1.9003
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 1.6144
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, PTGS2, PTGS1 1.9578
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, HTR2B, HTR2A 1.5488
Rheumatoid arthritis_Homo sapiens_hsa05323 CXCL8, MMP1, TEK 1.6144
Insulin resistance_Homo sapiens_hsa04931 PTPN1, INSR, PPARA 1.4456
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F2, F3 1.744
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CXCL8, CSNK2A1, PTGS2 1.596
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, CDC25B, HSPA1A 1.1704
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, ADRA1A, IGF1R 1.3108
Hepatitis C_Homo sapiens_hsa05160 CXCL8, PPARA, EGFR 1.2445
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, ESRRB, IGF1R 1.1902
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, CYP3A4, XDH 2.2661
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 CXCL8, INSR, PPARA 1.1462
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, PTGS2, EGFR 1.1195
Alcoholism_Homo sapiens_hsa05034 MAOB, DRD1, DRD2 1.0014
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, F2, EGFR 0.8681
HTLV-I infection_Homo sapiens_hsa05166 SMAD3 0.1586
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.2126
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.2261
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.2351
Tuberculosis_Homo sapiens_hsa05152 SRC 0.2432
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSPA1A 0.2553
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.2553
TNF signaling pathway_Homo sapiens_hsa04668 PTGS2, MMP9 0.7981
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.2793
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 0.8681
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 ADRA1A 0.2867
Platelet activation_Homo sapiens_hsa04611 SRC, PTGS1 0.7496
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.7605
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, ESR1 0.7605
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, EGFR 0.9255
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.3147
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 0.757
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 0.8867
Measles_Homo sapiens_hsa05162 CSNK2A1, HSPA1A 0.6996
Purine metabolism_Homo sapiens_hsa00230 PDE5A, XDH 0.5682
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3, CXCL8 0.8351
Prostate cancer_Homo sapiens_hsa05215 EGFR, IGF1R 0.9183
Taste transduction_Homo sapiens_hsa04742 HTR1A, GRM1 0.9562
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, HSPA1A 0.7605
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, GRIA4 0.8837
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1, AOX1 0.6256
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.691
Influenza A_Homo sapiens_hsa05164 CXCL8, HSPA1A 0.5682
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, HSPA1A 0.5147
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 0.9066
Cell cycle_Homo sapiens_hsa04110 SMAD3, CDC25B 0.7421
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, INSR 0.6981
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.6981
Axon guidance_Homo sapiens_hsa04360 MET 0.3291
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.691
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.3367
Chemokine signaling pathway_Homo sapiens_hsa04062 CXCL8, SRC 0.5502
Vascular smooth muscle contraction_Homo sapiens_hsa04270 ADRA1A 0.3419
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.3648
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 CXCL8 0.3775
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 0.9991
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.3912
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.3912
Amoebiasis_Homo sapiens_hsa05146 CXCL8 0.3912
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.4007
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.4
Glioma_Homo sapiens_hsa05214 EGFR, IGF1R 1.1195
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.4176
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.4199
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.4176
Salivary secretion_Homo sapiens_hsa04970 ADRA1A 0.4176
Salmonella infection_Homo sapiens_hsa05132 CXCL8 0.4177
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4176
Small cell lung cancer_Homo sapiens_hsa05222 PTGS2 0.4177
Bile secretion_Homo sapiens_hsa04976 CA2, CYP3A4 1.0618
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.4167
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, EGFR 1.114
Peroxisome_Homo sapiens_hsa04146 XDH 0.4211
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.1846
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3 0.4549
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.1195
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.4549
Pertussis_Homo sapiens_hsa05133 CXCL8 0.4514
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.445
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.4531
Legionellosis_Homo sapiens_hsa05134 CXCL8, HSPA1A 1.1946
Shigellosis_Homo sapiens_hsa05131 CXCL8, SRC 1.1195
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.4638
RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 CXCL8 0.4638
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.169
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.4791
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.4873
Malaria_Homo sapiens_hsa05144 CXCL8, MET 1.2753
Colorectal cancer_Homo sapiens_hsa05210 SMAD3 0.4958
NOD-like receptor signaling pathway_Homo sapiens_hsa04621 CXCL8 0.5209
Non-small cell lung cancer_Homo sapiens_hsa05223 EGFR 0.5242
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.5491
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2 0.5502
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOB 0.5538
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.5661
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.567
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.5661
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.4289
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR 0.6256
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.6144
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2, CYP3A4 1.6245
Tyrosine metabolism_Homo sapiens_hsa00350 MAOB, AOX1 1.5193
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOB 0.6192
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.6611
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.5799
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.5027
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.7303
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.6981
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.7051
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.7975
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7371
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.6996
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7303
Histidine metabolism_Homo sapiens_hsa00340 MAOB 0.757
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOB 0.8681
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.9183
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.0246
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.1902


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)