TCM Prescription: Bu Yi Di Huang Pills



Prescription Description
Prescription IDTCMF3076
Pinyin NameBu Yi Di Huang Wan
Chinese Name补益地黄丸
English NameBu Yi Di Huang Pills
Function Description腰痛
IndicationsLumbago disorder, Lumbago
Disease ICD-11 Category SC61 [Lumbago disorder (TM1), 腰痛 (TM1) ];
ME84.2Z [Low back pain, unspecified, 下腰痛，未特指的 ];
Human Tissues Associated with IndicationKidney, Bladder
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1966 Rehmannia glutinosa 熟地黄 TCMH1966 ITSAH4578-14
TCMH241 Plantago asiatica 车前子 TCMH241 ITSAB3641-14
TCMH2149 Cuscuta australis 菟丝子 TCMH2149 ITSAP4209-14
TCMH826 Terminalia chebula 诃子 TCMH826
TCMH2618 Citrus aurantium 枳壳 TCMH2618 ITSAA1279-14
TCMH449 Cortex lycii radicis 地骨皮 TCMH449
TCMH1588 Achyranthes bidentata 牛膝 TCMH1588 ITSAJ4612-14
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT151 PRKCA Protein kinase C alpha Kinase P17252
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT221 ABCB11 Bile salt export pump Transporter O95342
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT561 NT5E 5'-nucleotidase Hydrolase P21589
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT598 TOP1 DNA topoisomerase I Isomerase P11387
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT636 POLA1 DNA polymerase alpha subunit Transferase P09884
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1191 Bacillus megaterium
TCMT1208 Escherichia coli K12
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1318 Human T-lymphotropic virus 1
TCMT1319 Corynebacterium xerosis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1354 Streptococcus mutans UA159
TCMT1361 Neisseria meningitidis
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1393 Vibrio sp.
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, EGFR, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HSD17B1, HSD17B2, HSPA1A, INSR, KDR, MET, POLA1, POLB, PPARA, PRKCA, SLC1A1, SMAD3, SRC, TEK, XDH 8.57121
[BP] GO:0007215 None APP, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 8.188
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 8.188
[BP] GO:0010033 response to organic substance AKR1B1, APP, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD17B2, HSPA1A, IGF1R, INSR, KDR, POLB, PPARA, PRKCA, RORC, SMAD3, SRC, TEK, TYR 7.84054
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA6, CA7, CA9 7.31972
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, BACE1, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FLT3, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 6.75702
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, MET, PPARA, TBXAS1 6.67259
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, BACE1, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FLT3, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 6.67259
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, FLT3, GPR35, GRM1, HSPA1A, INSR, KDR, MET, MMP12, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 6.65216
[BP] GO:0042221 response to chemical AKR1B1, APP, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FLT3, GRIK5, GRM5, HSD17B2, HSPA1A, IGF1R, INSR, KDR, POLB, PPARA, PRKCA, RORC, SMAD3, SRC, TEK, TOP1, TYR 6.65216
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, FLT3, GPR35, GRM1, HSPA1A, INSR, KDR, MET, MMP12, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 6.65216
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, BACE1, CA2, CA7, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8 6.56497
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, BACE1, CA2, CA7, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8 6.56497
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, APP, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, HSPA1A, PIM1, PPARA, TBXAS1, TYR, XDH 6.43119
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, APP, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, GRIK5, GRM5, HSD17B2, IGF1R, INSR, POLB, PPARA, RORC, SRC, TEK, TYR 6.42168
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 6.12276
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APP, AXL, CA12, CA2, CA7, EGFR, FABP3, FABP4, FLT3, GPR35, GRIK5, GRM1, GRM5, INSR, MET, POLA1, POLB, SMAD3, SRC 5.97951
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AXL, CYP1B1, EGFR, FLT3, GPR35, GRM1, HSPA1A, INSR, KDR, MET, PRKCA, PTPN1, SRC, TEK, XDH 5.89439
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, APP, CDC25B, DUSP3, EGFR, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, NUAK1, PPARA, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 5.68013
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, APP, CDC25B, DUSP3, EGFR, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, NUAK1, PPARA, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 5.62643
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, APP, CDC25B, CSNK2A1, CYP1B1, EGFR, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP12, NUAK1, PIM1, PRKCA, SMAD3, SRC, TEK, XDH 5.43903
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK, TOP1 5.39193
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, APP, AURKB, AXL, CA2, CA6, CA9, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MMP12, NUAK1, POLA1, POLB, PPARA, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, TOP1, TYR 5.36522
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, APP, AURKB, AXL, CSNK2A1, CYP1B1, DUSP3, EGFR, FLT3, GPR35, GRM1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PRKCA, PTPN1, SRC, TEK, XDH 5.36403
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, CA1, CSNK2A1, EGFR, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, PRKCA, PTPN1, SMAD3, SRC, TEK 5.35446
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MET, PIM1, PPARA, PRKCA, PTPN1, SMAD3, SRC, TEK 5.34751
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, APP, AXL, CSNK2A1, CYP1B1, EGFR, FLT3, GPR35, GRM1, HSPA1A, INSR, KDR, MET, MMP12, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 5.34683
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.28542
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.23485
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 5.21756
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MET, PIM1, PRKCA, PTPN1, SMAD3, SRC, TEK 5.14939
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, TYR 5.1474
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, APP, AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLB, PRKCA, PTPN1, SRC, TEK, TOP1, XDH 4.935
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, FLT3, GRIK5, HSPA1A, IGF1R, KDR, MET, PIM1, PPARA, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 4.8958
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, FLT3, HSD17B2, INSR, KDR, POLB, PPARA, SMAD3, SRC, TEK, TYR 4.8958
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, EGFR, GRM1, GRM3, GRM5, GRM8 4.82867
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, FLT3, GRIK5, HSPA1A, IGF1R, KDR, MET, PIM1, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 4.73232
[BP] GO:0006793 phosphorus metabolic process ACHE, APP, AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLB, PRKCA, PTPN1, SRC, TEK, TOP1, XDH 4.60119
[BP] GO:0043408 regulation of MAPK cascade ADORA1, APP, DUSP3, EGFR, FLT3, GRM1, IGF1R, INSR, KDR, PRKCA, PTPN1, SRC, TEK, XDH 4.59426
[BP] GO:0051716 cellular response to stimulus AKR1B1, APP, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, FLT3, GRIK5, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, NUAK1, POLA1, POLB, PTPN1, RORC, SMAD3, SRC 4.52911
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, GPR35, GRIK5, GRM5, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, PPARA, PRKCA, PTPN1, SMAD3, SRC, TEK 4.52911
[BP] GO:0009719 response to endogenous stimulus AKR1B1, APP, CA2, CA9, CSNK2A1, CYP1A2, EGFR, FABP3, FLT3, GRM5, IGF1R, INSR, PPARA, SMAD3, SRC, TEK 4.52911
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, PIM1, PRKCA, PTPN1, SMAD3, SRC, TEK 4.5227
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, APP, EGFR, FLT3, GRM1, INSR, KDR, PRKCA, PTPN1, SRC, TEK, XDH 4.51961
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.48396
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, FABP3, PPARA, SLC1A1 4.46462
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2 4.45358
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK, TOP1 4.39668
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APP, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, PRKCA, SMAD3, SRC, TEK 4.27725
[BP] GO:0007193 None ADORA1, CHRM2, GRM1, GRM3, GRM5, GRM8 4.27011
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, APP, AURKB, AXL, BACE1, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLA1, POLB, PPARA, PRKCA, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TOP1, TYR, XDH 4.21999
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, FLT3, GRIK5, HSPA1A, IGF1R, KDR, PIM1, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 4.18509
[BP] GO:0010035 response to inorganic substance AKR1B1, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, SRC 4.07547
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, CA12, CA2, CA7, EGFR, FABP3, FABP4, GPR35, GRIK5, GRM1, GRM5, INSR, MET, SMAD3 4.03939
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, FABP3, FLT3, GPR35, GRIK5, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, PIM1, PPARA, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 4.03616
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APP, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, PRKCA, SMAD3, SRC, TEK 3.98526
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, APP, CDC25B, EGFR, FABP3, FLT3, GRM1, GRM5, INSR, KDR, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 3.96114
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, APP, CDC25B, EGFR, FABP3, FLT3, GRM1, GRM5, INSR, KDR, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 3.96114
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FUT7, MET, PPARA, TBXAS1 3.94971
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.93019
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, AURKB, AXL, BACE1, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, POLA1, POLB, PPARA, PRKCA, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TOP1, TYR, XDH 3.9103
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, AURKB, CDC25B, CSNK2A1, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM3, GRM5, HSPA1A, IGF1R, INSR, NUAK1, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 3.86971
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, GPR35, GRIK5, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, PIM1, PPARA, PRKCA, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, XDH 3.86971
[BP] GO:0033993 response to lipid AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, EGFR, FABP3, FLT3, HSD17B2, RORC, SRC, TYR 3.86971
[BP] GO:0043549 regulation of kinase activity ADORA1, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, IGF1R, INSR, PTPN1, SRC, TEK 3.868
[BP] GO:0014070 response to organic cyclic compound APP, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FLT3, RORC, SRC, TEK, TYR 3.84533
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, PRKCA, PTPN1, SRC, TEK 3.8192
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, CA2, CYP1A1, EGFR, GRM1, HSPA1A, POLB, PPARA, SMAD3, SRC, TEK, TYR 3.78445
[BP] GO:0080134 regulation of response to stress ADORA1, APP, CYP19A1, DUSP3, EGFR, FABP4, HSPA1A, IGF1R, MET, MMP12, NUAK1, PPARA, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 3.76155
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, APP, AURKB, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, FABP4, FLT3, GPR35, GRM1, GRM3, GRM5, HSPA1A, IGF1R, INSR, MET, NUAK1, PIM1, PPARA, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 3.75259
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, TBXAS1 3.75196
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, IGF1R, INSR, PTPN1, SRC, TEK 3.73711
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 3.71716
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, DUSP3, FABP4, GPR35, GRM3, IGF1R, MET, PIM1, PPARA, PRKCA, PTPN1, SRC 3.71716
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, APP, AXL, CSNK2A1, CYP1B1, EGFR, FABP4, FLT3, GPR35, GRM1, HSPA1A, INSR, KDR, MET, MMP12, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 3.71716
[BP] GO:0019369 arachidonic acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1, TBXAS1 3.7095
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, APP, AXL, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, FLT3, GRIK5, GRM5, HSPA1A, IGF1R, INSR, KDR, RORC, SMAD3, SRC 3.70402
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APP, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, PRKCA, SMAD3, SRC, TEK 3.69208
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APP, CYP19A1, CYP1B1, EGFR, IGF1R, INSR, KDR, MET, PRKCA, SMAD3, SRC, TEK 3.67876
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.66679
[BP] GO:0042325 regulation of phosphorylation ADORA1, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, IGF1R, INSR, KDR, PPARA, PRKCA, PTPN1, SRC, TEK, XDH 3.64521
[BP] GO:0006690 icosanoid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, TBXAS1 3.63044
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, APP, AURKB, AXL, CA2, CA9, CBR1, CDC25B, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP4, FLT3, FUT7, HSD17B2, INSR, KDR, MET, PIM1, POLB, PPARA, PRKCA, RORC, SMAD3, SRC, TEK, TYR 3.59532
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, APP, AXL, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP4, GRM1, GRM5, GRM8, HSD17B2, IGF1R, INSR, MET, MMP12, PIM1, PPARA, RORC, SMAD3, SRC, TEK, TOP1, TYR 3.56043
[BP] GO:0009725 response to hormone AKR1B1, CA2, CA9, CSNK2A1, CYP1A2, EGFR, FABP3, FLT3, INSR, PPARA, SRC, TEK 3.56043
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.56014
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, APP, AXL, CA1, CA2, CHRM2, CSNK2A1, CYP1B1, EGFR, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLB, PPARA, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK 3.56014
[BP] GO:0035235 None APP, GRIA2, GRIA4, GRIK5 3.56014
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, FABP3, PPARA, SLC1A1 3.56014
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, IGF1R, INSR, PTPN1, SRC 3.56014
[BP] GO:0071310 cellular response to organic substance AKR1B1, APP, AXL, CYP1A1, CYP1B1, EGFR, FABP4, FLT3, GRIK5, GRM5, IGF1R, INSR, KDR, RORC, SMAD3, SRC 3.5587
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, IGF1R, INSR, KDR, PRKCA, PTPN1, SRC, TEK, XDH 3.53817
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, FLT3, GRM1, IGF1R, INSR, PTPN1, SRC 3.53501
[BP] GO:0030335 positive regulation of cell migration APP, EGFR, IGF1R, INSR, KDR, MET, PRKCA, SMAD3, SRC, TEK 3.521
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, PRKCA, PTPN1, SMAD3, SRC, TEK 3.50465
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, APP, CDC25B, EGFR, FLT3, GRM1, GRM5, INSR, KDR, PRKCA, PTPN1, SRC, TEK, XDH 3.46362
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, GRM5, IGF1R, INSR, PPARA, SRC, TEK 3.46168
[BP] GO:2000147 positive regulation of cell motility APP, EGFR, IGF1R, INSR, KDR, MET, PRKCA, SMAD3, SRC, TEK 3.40263
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.38615
[BP] GO:0031399 regulation of protein modification process ADORA1, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, NUAK1, PRKCA, PTPN1, SRC, TEK, XDH 3.3589
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, APP, AURKB, AXL, BACE1, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CBR1, CDC25B, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, POLA1, POLB, PPARA, PRKCA, PTPN1, RORC, SLC1A1, SMAD3, SRC, TBXAS1, TEK, TOP1, TYR, XDH 3.33983
[BP] GO:0051272 positive regulation of cellular component movement APP, EGFR, IGF1R, INSR, KDR, MET, PRKCA, SMAD3, SRC, TEK 3.3133
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade APP, DUSP3, EGFR, KDR, PRKCA, PTPN1, SRC, TEK 3.29651
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, APP, CDC25B, EGFR, FLT3, GRM1, GRM5, INSR, KDR, PRKCA, PTPN1, SRC, TEK, XDH 3.279
[BP] GO:0045787 positive regulation of cell cycle APP, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, INSR, PRKCA, SRC 3.279
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5 3.21744
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.21744
[BP] GO:0040017 positive regulation of locomotion APP, EGFR, IGF1R, INSR, KDR, MET, PRKCA, SMAD3, SRC, TEK 3.20082
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, APP, AXL, CA2, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FLT3, HSD17B2, INSR, KDR, PIM1, POLB, PPARA, RORC, SMAD3, SRC, TEK, TYR 3.17666
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, PRKCA, SRC, TEK, TOP1 3.13984
[BP] GO:0060078 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5 3.10014
[BP] GO:0051049 regulation of transport ACHE, ADORA1, APP, AXL, CA2, CA7, CYP19A1, EGFR, GPR35, GRIK5, GRM5, HSPA1A, INSR, MMP12, PPARA, PRKCA, PTPN1, SMAD3, SRC 3.10014
[BP] GO:0006631 fatty acid metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, TBXAS1 3.08819
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, INSR, MET, SRC, TEK, XDH 3.06856
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, EGFR, HSD17B1, HSD17B2, PRKCA 3.06513
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2, TBXAS1, TYR, XDH 3.06407
[BP] GO:0042391 None ADORA1, APP, GPR35, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC 3.05974
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, EGFR, FABP3, FLT3, GRM5, IGF1R, INSR, PPARA, SRC, TEK, TYR 3.05967
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, APP, AURKB, AXL, CSNK2A1, CYP1B1, DUSP3, EGFR, FLT3, GPR35, GRM1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 2.99807
[BP] GO:0045931 positive regulation of mitotic cell cycle APP, CDC25B, CYP1A1, DUSP3, INSR, PRKCA 2.96718
[BP] GO:0008283 cell proliferation ACHE, AURKB, CYP1A1, EGFR, FLT3, MET, PIM1, POLA1, SRC, TEK, TYR 2.92269
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.89846
[BP] GO:0007346 regulation of mitotic cell cycle APP, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, PRKCA, SMAD3 2.8981
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, INSR, MET, SRC, TEK 2.85406
[BP] GO:0050730 None ADORA1, APP, EGFR, FLT3, GRM5, PTPN1, SRC 2.85406
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, EGFR, FLT3, GRM1, GRM5, INSR, PTPN1, SRC, TEK 2.82728
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.8175
[BP] GO:1901568 fatty acid derivative metabolic process ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, TBXAS1 2.8175
[BP] GO:0007188 None ADORA1, CHRM2, GRM1, GRM3, GRM5, GRM8 2.80403
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, EGFR, FLT3, GRM1, GRM5, INSR, PTPN1, SRC, TEK 2.76884
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, EGFR, FABP3, FLT3, GRM5, IGF1R, INSR, PPARA, SRC, TEK, TYR 2.76884
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, APP, CDC25B, CSNK2A1, EGFR, FLT3, GRM1, GRM5, HSPA1A, INSR, KDR, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 2.75937
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, GPR35, GRM3, GRM8, HSPA1A, IGF1R, KDR, MET, MMP12, PIM1, PPARA, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 2.63335
[BP] GO:0001676 long-chain fatty acid metabolic process CBR1, CYP1A1, CYP1A2, CYP1B1, TBXAS1 2.63247
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, EGFR, GRIK5, INSR, SLC1A1, SMAD3 2.62293
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.62293
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.62293
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.62293
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.62293
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, MMP12, PPARA, SMAD3, TEK 2.6152
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FLT3, PPARA, RORC, SRC, TEK 2.5483
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, EGFR, FLT3, GRM1, INSR, PTPN1, SRC 2.53733
[BP] GO:0042493 response to drug AKR1B1, AXL, CA9, CYP1A1, CYP1B1, EGFR, FABP3, KDR, POLB, SRC, TOP1 2.52653
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.51865
[BP] GO:0009611 response to wounding ACHE, ADORA3, CYP1A1, EGFR, PPARA, SMAD3 2.51865
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, SRC 2.50494
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, APP, CDC25B, EGFR, FLT3, GRM1, GRM5, HSPA1A, INSR, KDR, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 2.50494
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, PIM1, PRKCA, TEK 2.5035
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.49432
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.49432
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.49432
[BP] GO:0007187 None ADORA1, CHRM2, GRM1, GRM3, GRM5, GRM8 2.48641
[BP] GO:0099566 None GRM1, GRM5 2.48641
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.48641
[BP] GO:0031401 positive regulation of protein modification process ADORA1, APP, CDC25B, EGFR, FLT3, GRM1, GRM5, INSR, KDR, PRKCA, PTPN1, SRC, TEK, XDH 2.47035
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AXL, CYP1B1, EGFR, GRIK5, GRM5, IGF1R, INSR, RORC, SRC 2.47017
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, APP, AURKB, CDC25B, CSNK2A1, EGFR, FLT3, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, PPARA, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 2.45237
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.42927
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, PPARA, SMAD3, TEK 2.41523
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, DUSP3, EGFR, FLT3, GRM1, IGF1R, INSR, PTPN1, SRC 2.41523
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FABP4, FLT3, GPR35, GRM1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PPARA, PRKCA, PTPN1, SMAD3, SRC, TEK, XDH 2.39853
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, EGFR, PPARA, RORC, SRC, TOP1 2.39615
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, HSPA1A, SRC 2.37759
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.37632
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, AKR1B1, APP, AURKB, AXL, BACE1, CA1, CA12, CA2, CA7, CA9, CDC25B, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, POLA1, POLB, PPARA, PRKCA, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, TOP1, XDH 2.36971
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, EGFR, FLT3, GRM1, GRM5, INSR, PTPN1, SRC 2.36134
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade APP, EGFR, KDR, PRKCA, SRC, TEK 2.3547
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, EGFR, FABP4, KDR, MET, MMP12, PPARA, PRKCA, SMAD3, TEK 2.3547
[BP] GO:0070482 response to oxygen levels ADORA1, CYP1A1, POLB, PPARA, SMAD3, SRC, TEK 2.3547
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, APP, AURKB, CDC25B, EGFR, FLT3, GRM1, GRM5, HSPA1A, INSR, PTPN1, SMAD3, SRC, TEK, XDH 2.3547
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.3547
[BP] GO:0007268 None CHRM2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 2.3547
[BP] GO:0098916 None CHRM2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 2.3547
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, EGFR 2.35409
[BP] GO:0044057 None ADORA1, ADORA3, CHRM2, EGFR, GPR35, GRM1, PRKCA, SLC1A1, SMAD3 2.35409
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, EGFR, FABP4, HSPA1A, MMP12, PPARA, PTPN1, SMAD3, SRC, TEK 2.35409
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, SRC, TEK 2.32722
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CBR1, CYP1A1, CYP1A2, CYP1B1, EGFR, HSPA1A 2.30711
[BP] GO:0099536 None CHRM2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 2.30711
[BP] GO:0099537 None CHRM2, GRIA2, GRIK5, GRM1, GRM3, GRM5, SLC1A1 2.30711
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.30572
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, EGFR 2.30572
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, PRKCA, SRC, TEK 2.30572
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.27302
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.27302
[BP] GO:1901653 cellular response to peptide AKR1B1, APP, GRM5, IGF1R, INSR, SRC 2.27302
[BP] GO:0050801 ion homeostasis APP, CA12, CA2, CA7, EGFR, FABP3, GPR35, GRM1, GRM5, SMAD3 2.26724
[BP] GO:0051894 None KDR, SMAD3, TEK 2.26372
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.26372
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, BACE1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, HSPA1A, MMP12, SRC, XDH 2.24116
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, FABP3, GRIA2, GRIA4, GRIK5, PPARA, SLC1A1 2.212
[BP] GO:0032872 regulation of stress-activated MAPK cascade APP, DUSP3, EGFR, IGF1R, PTPN1, XDH 2.20491
[BP] GO:0070302 regulation of stress-activated protein kinase signaling cascade APP, DUSP3, EGFR, IGF1R, PTPN1, XDH 2.1961
[BP] GO:0009893 positive regulation of metabolic process ADORA1, APP, AURKB, CDC25B, CSNK2A1, EGFR, FABP3, FLT3, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, PPARA, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 2.1961
[BP] GO:0060079 None ADORA1, GRIA2, GRIA4, GRIK5 2.19501
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, APP, AURKB, CDC25B, EGFR, FABP3, FLT3, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, PPARA, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 2.19138
[BP] GO:1903393 None KDR, SMAD3, TEK 2.17298
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, APP, AURKB, CDC25B, CSNK2A1, EGFR, FLT3, GRM1, GRM5, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, PPARA, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, XDH 2.17053
[BP] GO:1900543 None GRM3, GRM8, PPARA, PRKCA 2.1527
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.13205
[BP] GO:0045980 None GRM3, GRM8, PPARA, PRKCA 2.13205
[BP] GO:1904646 cellular response to amyloid-beta APP, GRM5, IGF1R 2.13062
[BP] GO:0051726 regulation of cell cycle APP, AURKB, CDC25B, CSNK2A1, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, PIM1, PRKCA, SMAD3, SRC 2.11199
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, APP, AURKB, CA9, CDC25B, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, POLA1, PPARA, PRKCA, PTPN1, RORC, SMAD3, SRC, TEK, TOP1, XDH 2.11161
[BP] GO:0061097 None ADORA1, APP, GRM5, PTPN1 2.09174
[BP] GO:0050678 None EGFR, KDR, MMP12, PRKCA, SMAD3, TEK, XDH 2.08956
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, APP, AURKB, AXL, BACE1, CDC25B, CSNK2A1, CYP1A1, CYP1A2, DUSP3, EGFR, FLT3, FUT7, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, POLB, PPARA, PRKCA, PTPN1, SMAD3, SRC, TEK, TOP1, TYR, XDH 2.08956
[BP] GO:0035556 intracellular signal transduction AKR1B1, AXL, CYP1B1, EGFR, GRM5, IGF1R, INSR, KDR, MET, NUAK1, POLB, PRKCA, PTPN1, SRC, TEK 2.07688
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, APP, AXL, CA2, CHRM2, CYP1B1, EGFR, GPR35, GRM1, HSPA1A, INSR, KDR, MET, MMP12, PIM1, PRKCA, SLC1A1, SMAD3, SRC, TEK, XDH 2.07584
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AXL, CA2, CYP1B1, EGFR, HSPA1A, KDR, MET, MMP12, PIM1, PRKCA, SLC1A1, SMAD3, SRC, TEK 2.05769
[BP] GO:0031100 animal organ regeneration AXL, CSNK2A1, EGFR, FLT3 2.05714
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, APP, AURKB, AXL, BACE1, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, POLA1, POLB, PPARA, PRKCA, PTPN1, RORC, SMAD3, SRC, TBXAS1, TEK, TOP1, TYR, XDH 2.03963
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, SRC, TEK 2.01381
[BP] GO:0042743 hydrogen peroxide metabolic process CYP1A1, CYP1A2, EGFR 2.01381
[BP] GO:1904645 response to amyloid-beta APP, GRM5, IGF1R 2.01381
[BP] GO:0006979 response to oxidative stress AKR1B1, APP, AXL, CYP1B1, EGFR, HSPA1A, SRC 2.0012
[CC] GO:0098590 plasma membrane region ADORA1, CA2, CA4, CA9, CHRM2, EGFR, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, INSR, MET, SLC1A1, SRC, TEK 5.89439
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, APP, AXL, BACE1, CA2, CA4, CA9, CHRM2, DUSP3, EGFR, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, SLC1A1, SRC, TEK 4.97575
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, APP, AXL, BACE1, CA4, CHRM2, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, SLC1A1, TEK 4.9433
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, APP, AXL, BACE1, CHRM2, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, SLC1A1, TEK 4.56037
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, APP, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CHRM2, CSNK2A1, EGFR, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, PIM1, PRKCA, PTPN1, SLC1A1, SMAD3, SRC, TEK 4.27011
[CC] GO:0043235 receptor complex APP, EGFR, GRIA2, GRIA4, GRIK5, GRM1, IGF1R, INSR, SMAD3 3.66816
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 3.49936
[CC] GO:0044456 None ACHE, ADORA1, APP, CHRM2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SRC 3.38647
[CC] GO:0097060 None CHRM2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 3.17472
[CC] GO:0043005 None ADORA1, APP, BACE1, CA2, CHRM2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, SRC 2.89462
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX5, APP, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD17B2, IGF1R, INSR, KDR, MET, PIM1, PRKCA, PTPN1, SLC1A1, SMAD3, SRC, TBXAS1, TEK, TYR 2.70417
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, APP, AXL, BACE1, CA12, CA14, CA2, CA4, CA9, CHRM2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FLT3, FUT7, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSD17B2, IGF1R, INSR, KDR, MET, PTPN1, SLC1A1, SRC, TBXAS1, TEK, TYR 2.69003
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, TEK 2.46236
[CC] GO:0097458 None ADORA1, APP, BACE1, CA2, CHRM2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, INSR, SRC, TOP1 2.39981
[CC] GO:0043197 None ADORA1, APP, GRIA2, GRIA4, GRM3 2.37368
[CC] GO:0044309 None ADORA1, APP, GRIA2, GRIA4, GRM3 2.3547
[CC] GO:0014069 None ADORA1, GRIK5, GRM1, GRM3, GRM5, SRC 2.3547
[CC] GO:0099572 None ADORA1, GRIK5, GRM1, GRM3, GRM5, SRC 2.3547
[CC] GO:0045121 membrane raft APP, BACE1, EGFR, INSR, KDR, SRC, TEK 2.35233
[CC] GO:0098857 membrane microdomain APP, BACE1, EGFR, INSR, KDR, SRC, TEK 2.33542
[CC] GO:0120025 None ADORA1, AKR1B1, APP, BACE1, CA2, CHRM2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, SRC, TEK 2.1961
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 11.8965
[MF] GO:0046914 transition metal ion binding ALOX5, APP, CA1, CA12, CA2, CA4, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, MMP12, PIM1, PPARA, PRKCA, PTPN1, RORC, SMAD3, TBXAS1, TYR, XDH 8.73606
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, AURKB, AXL, BACE1, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, FLT3, FUT7, HSD17B1, HSD17B2, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, POLA1, POLB, PRKCA, PTPN1, SRC, TBXAS1, TEK, TOP1, TYR, XDH 8.1125
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 8.1125
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, POLB 8.1125
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9 7.66442
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.30789
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.63914
[MF] GO:0043167 ion binding ACHE, ALOX5, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, POLA1, POLB, PPARA, PRKCA, PTPN1, RORC, SLC1A1, SMAD3, SRC, TBXAS1, TEK, TOP1, TYR, XDH 6.52584
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, CHRM2, EGFR, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, PPARA, RORC, TEK 5.92154
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK, TOP1 5.72892
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, PRKCA, SRC, TEK, TOP1 5.72435
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.34751
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, POLB 5.31616
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, CHRM2, EGFR, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, TEK 5.22239
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, CHRM2, EGFR, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, TEK 5.22239
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, CHRM2, EGFR, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, PPARA, RORC, TEK 5.22239
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, CHRM2, EGFR, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, PPARA, RORC, SMAD3, TEK 5.22239
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLA1, POLB, PRKCA, SRC, TEK, TOP1 5.06988
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, CHRM2, EGFR, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, PPARA, RORC, TEK 5.03309
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK, TOP1 4.935
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK, TOP1 4.51961
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, HSD17B2, TBXAS1, TYR, XDH 3.82981
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, TYR 3.78776
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.71686
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, XDH 3.70402
[MF] GO:0036094 small molecule binding ADORA1, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLA1, PRKCA, SLC1A1, SRC, TEK, TOP1, XDH 3.56014
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.56014
[MF] GO:0030594 None CHRM2, GRIA2, GRIA4, GRIK5, GRM1, GRM5 3.55416
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA6, CA7, CA9, MMP12, PPARA, PRKCA, PTPN1, RORC, SMAD3 3.46168
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.34673
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, PIM1, PPARA, PTPN1, SMAD3, SRC 3.28409
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC, TBXAS1 3.21744
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, CBR1, HSD17B1, HSD17B2, XDH 3.08819
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, SRC, TBXAS1 3.06267
[MF] GO:0042562 hormone binding ACHE, EGFR, HSD17B1, IGF1R, INSR 2.92269
[MF] GO:0032403 protein complex binding ACHE, ADORA1, EGFR, FLT3, IGF1R, INSR, KDR, MMP12, PPARA, PTPN1, SMAD3, SRC 2.89462
[MF] GO:0043169 cation binding ACHE, ALOX5, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, MMP12, NUAK1, PIM1, POLA1, POLB, PPARA, PRKCA, PTPN1, RORC, SLC1A1, SMAD3, TBXAS1, TYR, XDH 2.8874
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, TBXAS1, TYR 2.8175
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.75349
[MF] GO:0005524 ATP binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK, TOP1 2.66888
[MF] GO:0046872 metal ion binding ALOX5, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, MMP12, NUAK1, PIM1, POLA1, POLB, PPARA, PRKCA, PTPN1, RORC, SLC1A1, SMAD3, TBXAS1, TYR, XDH 2.65096
[MF] GO:0032559 adenyl ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK, TOP1 2.56593
[MF] GO:0030554 adenyl nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SRC, TEK, TOP1 2.53733
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD17B1, POLA1, SRC, TBXAS1, XDH 2.50774
[MF] GO:0000166 nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLA1, PRKCA, SRC, TEK, TOP1, XDH 2.48641
[MF] GO:1901265 nucleoside phosphate binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLA1, PRKCA, SRC, TEK, TOP1, XDH 2.48641
[MF] GO:0099583 None GRM1, GRM5 2.48641
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.48641
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.48641
[MF] GO:0043168 anion binding APP, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PRKCA, SLC1A1, SRC, TEK, TOP1, XDH 2.44734
[MF] GO:0001540 amyloid-beta binding ACHE, BACE1, GRIA2, INSR 2.36177
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HSD17B1, HSD17B2 2.36177
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, BACE1, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP12, NUAK1, PIM1, PRKCA, PTPN1, SRC, TEK, TOP1 2.3547
[MF] GO:0097367 carbohydrate derivative binding ADORA1, APP, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, POLA1, PRKCA, SRC, TEK, TOP1 2.3547
[MF] GO:0019899 enzyme binding APP, AURKB, BACE1, CDC25B, CYP1A1, CYP1A2, DUSP3, EGFR, GRM5, HSPA1A, MET, POLA1, POLB, PPARA, PRKCA, PTPN1, SMAD3, SRC, TEK 2.32041
[MF] GO:0004971 None GRIA2, GRIA4 2.27302
[MF] GO:0051425 None APP, INSR 2.27302
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.24116
[MF] GO:0043559 insulin binding IGF1R, INSR 2.08956
[MF] GO:0043548 phosphatidylinositol 3-kinase binding AXL, IGF1R, INSR 2.05265


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA6, CA9, CA14 13.5678
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 9.5605
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, PRKCA, GRM1, GRIA4 8.4001
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 8.4001
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GRM3, CHRM2, GRIA2, GRM5, GPR35, ADORA3, GRIK5, GRM8, ADORA1, GRM1, GRIA4 7.4278
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 6.0886
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KDR, PRKCA, TEK, MET, EGFR, IGF1R 5.1089
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, INSR, GRM8, PRKCA, GRM1, EGFR 5.1089
Ras signaling pathway_Homo sapiens_hsa04014 INSR, KDR, PRKCA, TEK, MET, EGFR, IGF1R 3.8425
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, INSR, KDR, PRKCA, TEK, MET, EGFR, IGF1R 3.7258
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 3.64
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, PRKCA, GRM1, EGFR 3.8271
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, PRKCA, GRM1, GRIA4 3.64
Metabolic pathways_Homo sapiens_hsa01100 CBR1, AKR1B1, TYR, CYP19A1, POLA1, FUT7, AKR1B10, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, XDH 3.4963
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, PRKCA, TEK, EGFR, IGF1R 3.64
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, KDR, PRKCA, MET, EGFR, IGF1R 3.3742
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, PRKCA, MET, EGFR, IGF1R 3.3742
Long-term depression_Homo sapiens_hsa04730 GRIA2, PRKCA, GRM1, IGF1R 3.3829
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, GRM1, EGFR, IGF1R 3.2619
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, PRKCA, GRM1 3.2941
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, GRM5, PRKCA, GRM1, EGFR 2.7467
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CBR1, CYP1A2, CYP1A1, CYP1B1 3.1658
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, PRKCA, MET, EGFR, CDC25B 2.6498
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, GRM1, EGFR, HSPA1A 2.7467
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, GRIA2, ADORA1, PPARA, GRIA4 2.5923
Chemical carcinogenesis_Homo sapiens_hsa05204 CBR1, CYP1A2, CYP1A1, CYP1B1 3.0087
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, PRKCA, EGFR, CDC25B, HSPA1A 2.2256
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, FLT3, PRKCA, MET, EGFR, IGF1R 2.1663
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR, PRKCA 2.2714
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, ADORA1 2.3651
Glioma_Homo sapiens_hsa05214 PRKCA, EGFR, IGF1R 2.2326
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 2.2387
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, PRKCA, GRIA4 2.2256
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, TBXAS1 2.265
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.7467
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET, EGFR 2.2256
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 2.1943
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, PIM1, PRKCA 1.8309
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.2256
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, PRKCA, EGFR 1.9289
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, PRKCA, EGFR 1.9739
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, PRKCA, GRIA4 1.8864
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, PRKCA 1.744
Insulin resistance_Homo sapiens_hsa04931 PTPN1, INSR, PPARA 1.757
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, PPARA 2.2188
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5, PRKCA 1.7418
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1, PRKCA 1.6761
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.5393
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, PRKCA, GRIA4 1.6221
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1, PRKCA 1.534
Hepatitis B_Homo sapiens_hsa05161 SMAD3, SRC, PRKCA 1.5134
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC, PRKCA 1.5415
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, PRKCA, EGFR 1.4366
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, INSR, ADORA1 1.3919
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MET, IGF1R 1.3319
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, SRC, EGFR 1.1565
Platelet activation_Homo sapiens_hsa04611 SRC, TBXAS1 0.9519
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, PRKCA 1.0958
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.0958
Prostate cancer_Homo sapiens_hsa05215 EGFR, IGF1R 1.1439
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 1.112
Measles_Homo sapiens_hsa05162 CSNK2A1, HSPA1A 0.8894
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC, PRKCA 0.9722
Melanogenesis_Homo sapiens_hsa04916 PRKCA, TYR 1.0853
Morphine addiction_Homo sapiens_hsa05032 ADORA1, PRKCA 1.1321
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.9014
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, IGF1R 0.8668
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, IGF1R 0.9496
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, INSR 0.8778
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, HSPA1A 0.9722
Choline metabolism in cancer_Homo sapiens_hsa05231 PRKCA, EGFR 1.0828
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.8395
GABAergic synapse_Homo sapiens_hsa04727 SRC, PRKCA 1.1472
Cell cycle_Homo sapiens_hsa04110 SMAD3, CDC25B 0.9496
Pancreatic secretion_Homo sapiens_hsa04972 CA2, PRKCA 1.1011
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, HSPA1A 0.6838
Gastric acid secretion_Homo sapiens_hsa04971 CA2, PRKCA 1.2683
Alzheimer's disease_Homo sapiens_hsa05010 BACE1, APP 0.7836
Viral carcinogenesis_Homo sapiens_hsa05203 POLB, SRC 0.6832
Influenza A_Homo sapiens_hsa05164 PRKCA, HSPA1A 0.7755
Purine metabolism_Homo sapiens_hsa00230 POLA1, XDH 0.7755
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.2318
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.3345
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3426
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSPA1A 0.3664
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3522
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3418
HTLV-I infection_Homo sapiens_hsa05166 POLB, SMAD3 0.5857
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1 0.3859
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.394
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PRKCA 0.4025
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, EGFR 1.3488
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.4313
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PRKCA 0.4313
Non-small cell lung cancer_Homo sapiens_hsa05223 PRKCA, EGFR 1.4375
Axon guidance_Homo sapiens_hsa04360 MET 0.4471
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.4366
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.355
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4556
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PRKCA 0.4647
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1 1.355
Vascular smooth muscle contraction_Homo sapiens_hsa04270 PRKCA 0.4616
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.5046
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5124
Pyrimidine metabolism_Homo sapiens_hsa00240 POLA1 0.504
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.4149
Amoebiasis_Homo sapiens_hsa05146 PRKCA 0.5131
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PRKCA 0.5311
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PRKCA 0.5177
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5262
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5373
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.5311
Rheumatoid arthritis_Homo sapiens_hsa05323 TEK 0.5373
Taste transduction_Homo sapiens_hsa04742 GRM1 0.5458
Salivary secretion_Homo sapiens_hsa04970 PRKCA 0.5373
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.5444
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5373
Insulin secretion_Homo sapiens_hsa04911 PRKCA 0.5432
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 PRKCA 0.5485
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.5373
Peroxisome_Homo sapiens_hsa04146 XDH 0.5458
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3 0.5817
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PRKCA 0.5857
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.5837
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.5645
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5857
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2 1.534
Bile secretion_Homo sapiens_hsa04976 CA2 0.5857
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5933
Thyroid hormone synthesis_Homo sapiens_hsa04918 PRKCA 0.5857
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2 0.5857
Bladder cancer_Homo sapiens_hsa05219 SRC, EGFR 1.6457
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR, PRKCA 1.6718
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5981
Shigellosis_Homo sapiens_hsa05131 SRC 0.5957
mTOR signaling pathway_Homo sapiens_hsa04150 PRKCA 0.6162
Colorectal cancer_Homo sapiens_hsa05210 SMAD3 0.607
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.6586
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.8309
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.647
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.6617
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 PRKCA 0.647
Vibrio cholerae infection_Homo sapiens_hsa05110 PRKCA 0.6657
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2 0.6657
Malaria_Homo sapiens_hsa05144 MET 0.6741
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.6786
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 PRKCA 0.6832
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7878
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6838
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7231
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0128
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.7755
African trypanosomiasis_Homo sapiens_hsa05143 PRKCA 0.7755
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.8422
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.803
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.7755
Base excision repair_Homo sapiens_hsa03410 POLB 0.7836
DNA replication_Homo sapiens_hsa03030 POLA1 0.7755
Linoleic acid metabolism_Homo sapiens_hsa00591 CYP1A2 0.8216
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8486
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8119
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8422
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.1294


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)