TCM Prescription: Nao Li Bao Pills



Prescription Description
Prescription IDTCMF4720
Pinyin NameNao Li Bao Wan
Chinese Name脑力宝丸
English NameNao Li Bao Pills
Function Description健忘, 不寐, 盗汗
IndicationsForgetfulness disorder, Insomnia disorder, Insomnia
Disease ICD-11 Category SD23 [Forgetfulness disorder (TM1), 健忘 (TM1) ];
SD84 [Insomnia disorder (TM1), 不寐 (TM1) ];
7A0Z [Insomnia disorders, unspecified, 失眠障碍，未特指的 ];
Human Tissues Associated with IndicationHeart, Brain
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH2554 Polygala tenuifolia 远志 TCMH2554 MF096619
TCMH451 Rehmannia glutinosa 地黄 TCMH451 ITSAH4578-14
TCMH2202 Schisandra chinensis 五味子 TCMH2202 ITSAM2867-14
TCMH449 Cortex lycii radicis 地骨皮 TCMH449
TCMH2149 Cuscuta australis 菟丝子 TCMH2149 ITSAP4209-14
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH1920 Acorus tatarinowii 石菖蒲 TCMH1920 ITSAI4409-14
TCMH305 Cnidium officinale 川芎 TCMH305 ITSAP4207-14
TCMH2171 NA 维生素E TCMH2171
TCMH2168 NA 维生素B TCMH2168
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT332 AOC3 Amine oxidase, copper containing Oxidoreductase Q16853
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT594 PTAFR Platelet activating factor receptor GPCR P25105
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT81 ALOX12 Arachidonate 12-lipoxygenase Oxidoreductase P18054
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1191 Bacillus megaterium
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1250 Vesicular stomatitis virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1282 Colletotrichum orbiculare
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1319 Corynebacterium xerosis
TCMT1321 Staphylococcus hominis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, HMGCR, HSD11B1, HSD17B1, HSD17B2, MET, PPARA, TRPV1 10.5045
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, CYP3A4, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HMGCR, HSD11B1, HSD17B1, HSD17B2, KDR, MET, PPARA, PTAFR, SLC1A1, SRC, TRPV1, XDH 10.2674
[BP] GO:0007215 None APP, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 8.78159
[BP] GO:0044281 small molecule metabolic process AKR1B1, ALOX12, ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FUT7, HMGCR, PIM1, PPARA, PTAFR, TYR, XDH 8.00273
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, APP, AXL, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, GRIK5, GRM5, HMGCR, HSD17B2, IGF1R, MMP2, MMP9, NR3C1, PPARA, PTAFR, SRC, TRPV1, TYR 7.74907
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, APP, AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSD17B2, IGF1R, KDR, MMP2, NR3C1, PPARA, PTAFR, SRC, TRPV1, TYR 7.59895
[BP] GO:0008202 steroid metabolic process AKR1B1, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HMGCR, HSD11B1, HSD17B1, HSD17B2 6.93119
[BP] GO:0042221 response to chemical AKR1B1, ALOX15, APP, AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSD17B2, IGF1R, KDR, MMP2, MMP9, NR3C1, PPARA, PTAFR, SRC, TRPV1, TYR 6.49418
[BP] GO:0055114 oxidation-reduction process AKR1B1, ALOX12, ALOX15, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HMGCR, HSD11B1, HSD17B1, HSD17B2, TYR, XDH 5.74943
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 5.63063
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7 5.57512
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APP, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, SRC 5.39418
[BP] GO:0044255 cellular lipid metabolic process ACHE, ALOX12, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, HMGCR, MET, PPARA 5.38977
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, APP, AXL, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, MMP2, MMP9, NR3C1, PTAFR, SRC, TRPV1 5.20842
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 5.20522
[BP] GO:0019369 arachidonic acid metabolic process ALOX12, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1 5.18831
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, CA2, CA7, GRIK5, GRM1, GRM3, GRM5, GRM8 5.18831
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, CA2, CA7, GRIK5, GRM1, GRM3, GRM5, GRM8 5.18831
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1 5.18831
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5, PTAFR 5.11895
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, ALOX12, ALOX15, APP, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HMGCR, PTAFR, TYR 5.07744
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX12, ALOX15, CYP19A1, CYP3A4, HMGCR, PTAFR, TYR 5.07744
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, APP, AXL, CYP1A1, CYP1B1, FABP4, FLT3, GRIK5, GRM5, IGF1R, KDR, MMP2, NR3C1, PTAFR, SRC, TRPV1 5.07744
[BP] GO:0006690 icosanoid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1 5.07744
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD17B1, HSD17B2 5.02065
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, CA1, CSNK2A1, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MMP2, MMP9, PTAFR, SRC, TRPV1 5.02024
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HSD17B1, HSD17B2 4.99866
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX12, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HMGCR, HSD11B1, HSD17B1, HSD17B2 4.86155
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, FABP3, FLT3, GRIK5, GRM1, GRM5, HMGCR, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PTAFR, SRC, TRPV1, XDH 4.85957
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, GRIK5, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, PPARA, SRC, TRPV1, XDH 4.80243
[BP] GO:0009719 response to endogenous stimulus AKR1B1, APP, CA2, CSNK2A1, CYP1A2, FABP3, FLT3, GRM5, IGF1R, MMP2, NR3C1, PPARA, PTAFR, SRC, TRPV1 4.70902
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HMGCR, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PTAFR, SLC1A1, SRC, TRPV1, XDH 4.68926
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7 4.64942
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, ALOX12, ALOX15, ALOX5, APP, AXL, CYP19A1, CYP1A2, CYP1B1, FABP4, GRM1, GRM5, GRM8, HMGCR, HSD17B2, IGF1R, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTAFR, SRC, TRPV1, TYR 4.64402
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 4.6299
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HMGCR, HSD11B1, HSD17B1, HSD17B2 4.62615
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, GRIK5, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, SRC, TRPV1, XDH 4.59852
[BP] GO:0060078 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5, TRPV1 4.5474
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, ALOX12, APP, AXL, CA12, CA2, CA7, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, MET, SRC, TRPV1 4.53198
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APP, AXL, CYP1B1, GRIK5, GRM5, IGF1R, MMP2, MMP9, NR3C1, PTAFR, SRC, TRPV1 4.4459
[BP] GO:0006631 fatty acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA 4.39685
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, HMGCR, HSD11B1, HSD17B1, HSD17B2 4.38068
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ALOX12, ALOX15, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, GRIK5, GRM5, HMGCR, IGF1R, KDR, MET, MMP9, PPARA, PTAFR, SRC, TRPV1 4.35206
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, ALOX12, APP, CSNK2A1, CYP1B1, FABP3, FLT3, HMGCR, IGF1R, KDR, MMP2, MMP9, PIM1, PTAFR, SRC, XDH 4.22621
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, FABP3, PPARA, SLC1A1, TRPV1 4.22621
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, PPARA, SRC 4.20119
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, ALOX15, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, GRM1, HMGCR, KDR, MET, MMP9, SRC, XDH 4.19787
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, ALOX15, APP, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, GRM1, HMGCR, KDR, MET, MMP9, SRC, XDH 4.17686
[BP] GO:1901568 fatty acid derivative metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1 4.16918
[BP] GO:0019748 secondary metabolic process AKR1B1, CYP1A1, CYP1A2, CYP1B1, TYR 4.07616
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, GRIK5, HMGCR, IGF1R, KDR, MMP9, PIM1, SRC, TRPV1, XDH 4.05583
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX12, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1 4.04298
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, CA2, CYP1A1, GRM1, HMGCR, MMP2, PPARA, PTAFR, SRC, TRPV1, TYR 4.00093
[BP] GO:2001300 lipoxin metabolic process ALOX12, ALOX15, ALOX5 3.96547
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, APP, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, MMP9, PPARA, PTAFR, SRC, XDH 3.93408
[BP] GO:0033993 response to lipid AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, FABP3, FLT3, HSD17B2, NR3C1, PTAFR, SRC, TYR 3.91881
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, HMGCR, IGF1R, KDR, MET, MMP9, PIM1, SRC 3.90932
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ALOX15, APP, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, MMP9, PPARA, PTAFR, SRC, XDH 3.90813
[BP] GO:0014070 response to organic cyclic compound APP, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FLT3, NR3C1, PTAFR, SRC, TRPV1, TYR 3.90813
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.87945
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, APP, AURKB, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, GRIK5, GRM1, GRM5, IGF1R, KDR, MMP2, MMP9, NR3C1, PTAFR, SRC, TRPV1 3.85429
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, GRM1, GRM3, GRM5, GRM8 3.84299
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, MET, MMP9, SRC, XDH 3.81802
[BP] GO:0035235 None APP, GRIA2, GRIA4, GRIK5 3.76321
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, FLT3, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, IGF1R, KDR, MET, MMP9, SRC, XDH 3.7453
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APP, FABP3, FLT3, GRM5, IGF1R, MMP2, PPARA, PTAFR, SRC, TRPV1, TYR 3.7453
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ALOX12, APP, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PTAFR, SRC 3.68284
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, KDR, NR3C1, PTAFR, SRC, TRPV1 3.68134
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.64343
[BP] GO:0048878 chemical homeostasis AKR1B1, ALOX12, APP, CA12, CA2, CA7, FABP3, FABP4, GRIK5, GRM1, GRM5, MET, TRPV1 3.59514
[BP] GO:0060079 None ADORA1, GRIA2, GRIA4, GRIK5, TRPV1 3.57196
[BP] GO:0042391 None ADORA1, APP, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC, TRPV1 3.57196
[BP] GO:0009725 response to hormone AKR1B1, CA2, CSNK2A1, CYP1A2, FABP3, FLT3, NR3C1, PPARA, PTAFR, SRC, TRPV1 3.53511
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AXL, CYP1B1, FLT3, GRM1, HMGCR, KDR, MET, SRC, XDH 3.45913
[BP] GO:1901698 response to nitrogen compound AKR1B1, APP, FABP3, FLT3, GRM5, IGF1R, MMP2, PPARA, PTAFR, SRC, TRPV1, TYR 3.45029
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ALOX12, APP, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PTAFR, SRC 3.44331
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, FABP3, PPARA, SLC1A1, TRPV1 3.41835
[BP] GO:0007193 None ADORA1, GRM1, GRM3, GRM5, GRM8 3.40479
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, HMGCR, MMP2, MMP9, PTAFR 3.40479
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CSNK2A1, CYP1B1, FABP4, GRM3, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, SRC 3.3916
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.36306
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, FLT3, HSD11B1, HSD17B2, KDR, PPARA, SRC, TYR 3.31632
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AURKB, AXL, CSNK2A1, HMGCR, IGF1R, KDR, MMP9, PIM1, SRC 3.30987
[BP] GO:0044283 None AKR1B1, ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP3A4, HMGCR, PTAFR 3.30627
[BP] GO:0044070 regulation of anion transport ADORA1, CA2, CA7, GRM5, PTAFR 3.27054
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APP, AURKB, AXL, CA2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HMGCR, HSD17B2, IGF1R, KDR, MMP2, MMP9, NR3C1, PPARA, PTAFR, SRC, TRPV1, TYR 3.24486
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, CSNK2A1, CYP1B1, FLT3, GRM1, HMGCR, IGF1R, KDR, MET, MMP9, SRC, XDH 3.15395
[BP] GO:0042493 response to drug AKR1B1, AXL, CYP1A1, CYP1B1, FABP3, HMGCR, KDR, NR3C1, PTAFR, SRC, TRPV1 3.15395
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ALOX12, APP, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PTAFR, SRC 3.15395
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ALOX12, APP, CYP19A1, CYP1B1, IGF1R, KDR, MET, MMP9, PTAFR, SRC 3.1424
[BP] GO:0009056 catabolic process ACHE, ADORA1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FUT7, MMP1, MMP2, MMP9, SRC, XDH 3.11573
[BP] GO:1901652 response to peptide AKR1B1, APP, FABP3, GRM5, IGF1R, PPARA, SRC, TRPV1 3.11573
[BP] GO:0071407 cellular response to organic cyclic compound APP, CYP1A1, CYP1B1, FLT3, NR3C1, PTAFR, SRC, TRPV1 3.10081
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 3.0478
[BP] GO:0032787 None ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA 3.0464
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, ALOX5, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FLT3, FUT7, HMGCR, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PTAFR, SRC, TRPV1, TYR, XDH 3.02367
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ALOX15, APP, FABP3, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PTAFR, SRC, XDH 2.99163
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ALOX15, APP, FABP3, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PTAFR, SRC, XDH 2.99163
[BP] GO:2001301 lipoxin biosynthetic process ALOX12, ALOX15 2.94586
[BP] GO:2001302 lipoxin A4 metabolic process ALOX12, ALOX15 2.94586
[BP] GO:2001303 lipoxin A4 biosynthetic process ALOX12, ALOX15 2.94586
[BP] GO:0016042 lipid catabolic process ADORA1, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4 2.88361
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, ALOX15, APP, AXL, CSNK2A1, CYP1B1, FLT3, GRM1, HMGCR, KDR, MET, MMP9, SRC, XDH 2.86893
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, APP, FLT3, GRM1, HMGCR, KDR, SRC, XDH 2.85769
[BP] GO:0019372 lipoxygenase pathway ALOX12, ALOX15, ALOX5 2.80784
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, ALOX15, APP, AXL, CSNK2A1, CYP1B1, FABP4, FLT3, GRM1, HMGCR, KDR, MET, MMP2, MMP9, PTAFR, SRC, XDH 2.80749
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APP, GRM5, IGF1R, MMP2, PTAFR, SRC, TRPV1 2.79105
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.78537
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.78537
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.75143
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APP, FLT3, GRM5, IGF1R, MMP2, NR3C1, PTAFR, SRC, TRPV1 2.70614
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, APP, AURKB, AXL, CA2, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP4, FLT3, FUT7, HMGCR, HSD11B1, HSD17B2, KDR, MET, MMP2, MMP9, PIM1, PPARA, SRC, TYR 2.66192
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, APP, AXL, CA1, CA2, CSNK2A1, CYP1B1, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MMP2, MMP9, NR3C1, PIM1, PPARA, PTAFR, SRC, TRPV1 2.63665
[BP] GO:0019752 carboxylic acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PIM1, PPARA, TYR 2.63059
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, ALOX12, MET, TRPV1 2.63059
[BP] GO:0043393 regulation of protein binding APP, AURKB, MET, MMP9, PPARA, SRC 2.58842
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APP, GRM5, IGF1R, MMP2, PTAFR, SRC, TRPV1 2.58842
[BP] GO:0035588 None ADORA1, ADORA3, PTAFR 2.57007
[BP] GO:2000021 regulation of ion homeostasis ADORA1, CA2, CA7, KDR, SRC, TRPV1 2.57007
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ALOX15, APP, FLT3, GRM1, HMGCR, IGF1R, KDR, SRC, XDH 2.57007
[BP] GO:0099566 None GRM1, GRM5 2.57007
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.57007
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, ALOX12, CSNK2A1, FLT3, HMGCR, IGF1R, KDR, MMP2, MMP9, PIM1, PTAFR 2.54982
[BP] GO:0006720 isoprenoid metabolic process CYP1A1, CYP1A2, CYP1B1, CYP3A4, HMGCR 2.54982
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ALOX15, APP, AXL, CA2, CA7, CYP19A1, GRIK5, GRM5, HMGCR, MMP9, PPARA, PTAFR, SRC, TRPV1 2.53994
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.52566
[BP] GO:0010038 response to metal ion ALOX15, APP, CA2, CYP1A1, CYP1A2, FABP4, MMP9 2.52537
[BP] GO:0030335 positive regulation of cell migration ALOX12, APP, IGF1R, KDR, MET, MMP9, PTAFR, SRC 2.52511
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, APP, AURKB, AXL, CA1, CA12, CA2, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PTAFR, SLC1A1, SRC, TRPV1, XDH 2.51435
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, HMGCR, MMP2, MMP9, PTAFR 2.51435
[BP] GO:0001101 response to acid chemical AKR1B1, FABP3, HSD17B2, KDR, MMP2, PTAFR, SRC 2.50871
[BP] GO:2000147 positive regulation of cell motility ALOX12, APP, IGF1R, KDR, MET, MMP9, PTAFR, SRC 2.4267
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.42156
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.36668
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA7, FABP3, GRIA2, GRIA4, GRIK5, PPARA, SLC1A1, TRPV1 2.36472
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, APP, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MMP9, PPARA, SRC, XDH 2.35987
[BP] GO:0051272 positive regulation of cellular component movement ALOX12, APP, IGF1R, KDR, MET, MMP9, PTAFR, SRC 2.3518
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, HMGCR, KDR, SRC, TRPV1 2.32805
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, APP, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, SRC, XDH 2.32614
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.32614
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.32614
[BP] GO:0043436 oxoacid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PIM1, PPARA, TYR 2.32614
[BP] GO:0051240 positive regulation of multicellular organismal process ALOX12, APP, AXL, CA2, CYP1B1, HMGCR, KDR, MET, MMP9, PIM1, PTAFR, SLC1A1, SRC, TRPV1 2.29227
[BP] GO:0006706 steroid catabolic process CYP19A1, CYP1A2, CYP3A4 2.29227
[BP] GO:0040017 positive regulation of locomotion ALOX12, APP, IGF1R, KDR, MET, MMP9, PTAFR, SRC 2.27117
[BP] GO:0006082 organic acid metabolic process ALOX12, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PIM1, PPARA, TYR 2.26883
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, FABP4, MMP9 2.26481
[BP] GO:1904646 cellular response to amyloid-beta APP, GRM5, IGF1R 2.25843
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FLT3, HMGCR, PPARA, SRC 2.23869
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, APP, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, HSD11B1, HSD17B2, KDR, MMP9, PIM1, PPARA, SRC, TYR 2.23678
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, SRC 2.22554
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, APP, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, FABP3, FABP4, GRM3, GRM8, HMGCR, IGF1R, KDR, MET, MMP9, NR3C1, PIM1, PPARA, SRC, TRPV1, XDH 2.22354
[BP] GO:0035587 None ADORA1, ADORA3, PTAFR 2.222
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, APP, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, SRC, XDH 2.20264
[BP] GO:0007188 None ADORA1, GRM1, GRM3, GRM5, GRM8 2.18706
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ALOX15, APP, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MMP9, SRC, XDH 2.17986
[BP] GO:0051122 hepoxilin biosynthetic process ALOX12, ALOX15 2.15948
[BP] GO:0051121 hepoxilin metabolic process ALOX12, ALOX15 2.15948
[BP] GO:1904645 response to amyloid-beta APP, GRM5, IGF1R 2.1516
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, ALOX12, ALOX15, ALOX5, APP, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FLT3, FUT7, HMGCR, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, NR3C1, PIM1, PPARA, PTAFR, SRC, TYR, XDH 2.14533
[BP] GO:0006691 None ALOX12, ALOX15, ALOX5 2.11197
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7 2.07742
[BP] GO:0006775 fat-soluble vitamin metabolic process CBR1, CYP1A1, CYP3A4 2.03869
[BP] GO:0046165 None AKR1B1, CYP3A4, HMGCR, PTAFR 2.02616
[BP] GO:0006066 None AKR1B1, APP, CYP1B1, CYP3A4, HMGCR, PTAFR 2.02148
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, FABP4, MMP9 2.01674
[BP] GO:0009636 response to toxic substance AKR1B1, AXL, CYP1A1, CYP1B1, HMGCR, KDR, SRC 2.01674
[BP] GO:0051930 None ADORA1, GRM1, PTAFR 2.01674
[BP] GO:0051931 None ADORA1, GRM1, PTAFR 2.01674
[BP] GO:0002933 lipid hydroxylation CYP1A1, CYP3A4 2.01674
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP3A4 2.01674
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.00591
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, APP, AXL, CA4, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, PTAFR, SLC1A1, TRPV1 4.17686
[CC] GO:0098590 plasma membrane region ADORA1, CA2, CA4, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, MET, SLC1A1, SRC, TRPV1 4.09225
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX12, ALOX15, ALOX5, APP, AXL, CA12, CA14, CA2, CA4, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FLT3, FUT7, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSD11B1, HSD17B2, IGF1R, KDR, MET, MMP2, PIM1, PTAFR, SLC1A1, SRC, TRPV1, TYR 4.05779
[CC] GO:0044456 None ACHE, ADORA1, APP, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, SRC, TRPV1 4.05488
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALOX12, ALOX15, APP, AXL, CA12, CA14, CA2, CA4, CSNK2A1, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, MMP2, PIM1, PTAFR, SLC1A1, SRC, TRPV1 3.90932
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, APP, AXL, FLT3, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, PTAFR, SLC1A1, TRPV1 3.79199
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ALOX15, APP, AXL, CA2, CA4, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, PTAFR, SLC1A1, SRC, TRPV1 3.76559
[CC] GO:0042734 None GRIK5, GRM1, GRM3, GRM5, GRM8 3.76321
[CC] GO:0097060 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, TRPV1 3.63281
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ALOX15, APP, AXL, CA12, CA14, CA2, CA4, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FLT3, FUT7, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HMGCR, HSD11B1, HSD17B2, IGF1R, KDR, MET, PTAFR, SLC1A1, SRC, TRPV1, TYR 3.20962
[CC] GO:0014069 None ADORA1, GRIK5, GRM1, GRM3, GRM5, SRC 2.65048
[CC] GO:0099572 None ADORA1, GRIK5, GRM1, GRM3, GRM5, SRC 2.65048
[CC] GO:0043197 None ADORA1, APP, GRIA2, GRIA4, GRM3 2.63059
[CC] GO:0044309 None ADORA1, APP, GRIA2, GRIA4, GRM3 2.60309
[CC] GO:0043005 None ADORA1, APP, CA2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, SRC 2.27023
[CC] GO:0098794 None ADORA1, APP, GRIA2, GRIA4, GRM3 2.22554
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, ALOX5, APP, AURKB, CA1, CA2, CA4, CA7, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FLT3, FUT7, GRIA2, GRIA4, GRIK5, HMGCR, HSD11B1, HSD17B1, HSD17B2, KDR, MMP2, MMP9, NR3C1, PIM1, PTAFR, SRC, TRPV1, TYR, XDH 2.08345
[MF] GO:0046914 transition metal ion binding ALOX12, ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, TYR, XDH 9.91631
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 8.5413
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7 8.24586
[MF] GO:0016491 oxidoreductase activity AKR1B1, ALOX12, ALOX15, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HMGCR, HSD11B1, HSD17B1, HSD17B2, TYR, XDH 6.93119
[MF] GO:0005506 iron ion binding ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, XDH 6.11441
[MF] GO:0043167 ion binding ACHE, ALOX12, ALOX15, ALOX5, APP, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, FLT3, HMGCR, HSD17B1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, PTAFR, SLC1A1, SRC, TRPV1, TYR, XDH 6.11441
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.34465
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 5.18831
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7 5.18831
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FLT3, FUT7, HMGCR, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, SRC, TYR, XDH 5.18695
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, NR3C1, PPARA, PTAFR, TRPV1 5.08023
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7 4.59881
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, NR3C1, PPARA, PTAFR, TRPV1 4.49083
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, CBR1, HMGCR, HSD11B1, HSD17B1, HSD17B2, XDH 4.44972
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, NR3C1, PPARA, PTAFR, TRPV1 4.32956
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, PTAFR, TRPV1 4.30187
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, PTAFR, TRPV1 4.30187
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4 4.28874
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TYR 4.13945
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, FLT3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, IGF1R, KDR, MET, NR3C1, PPARA, PTAFR, TRPV1 4.0145
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.76321
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, CBR1, HMGCR, HSD11B1, HSD17B1, HSD17B2 3.70338
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, SRC 3.55236
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 3.47797
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, FLT3, IGF1R, KDR, MET, PIM1, PPARA, SRC, TRPV1 3.40872
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, SRC 3.40149
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 3.33627
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, TYR 3.15395
[MF] GO:0043169 cation binding ACHE, ALOX12, ALOX15, ALOX5, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, SLC1A1, TRPV1, TYR, XDH 3.07868
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, HMGCR, HSD17B1, SRC, XDH 3.02367
[MF] GO:0047977 hepoxilin-epoxide hydrolase activity ALOX12, ALOX15 2.94586
[MF] GO:0005231 None GRIA2, GRIA4, GRIK5, TRPV1 2.86893
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.83262
[MF] GO:0046872 metal ion binding ALOX12, ALOX15, ALOX5, APP, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, MMP1, MMP2, MMP9, NR3C1, PIM1, PPARA, SLC1A1, TRPV1, TYR, XDH 2.83145
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7 2.80357
[MF] GO:0030594 None GRIA2, GRIA4, GRIK5, GRM1, GRM5 2.77075
[MF] GO:0008289 lipid binding ALOX15, AXL, CYP3A4, FABP3, FABP4, HSD17B1, NR3C1, PPARA, PTAFR, TRPV1 2.74208
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.62177
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.62177
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.57007
[MF] GO:0004052 arachidonate 12-lipoxygenase activity ALOX12, ALOX15 2.57007
[MF] GO:0051120 hepoxilin A3 synthase activity ALOX12, ALOX15 2.57007
[MF] GO:0099583 None GRM1, GRM5 2.57007
[MF] GO:0099094 None GRIA2, GRIA4, GRIK5, TRPV1 2.45836
[MF] GO:0035586 None ADORA1, ADORA3, PTAFR 2.32614
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.32614
[MF] GO:0004971 None GRIA2, GRIA4 2.32614
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.32614
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX12, ALOX15, ALOX5 2.29227
[MF] GO:0005230 None GRIA2, GRIA4, GRIK5, TRPV1 2.26291
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD17B1, HSD17B2 2.25843
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX12, ALOX15, ALOX5 2.25843
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, MMP1, MMP2, MMP9, NR3C1, PPARA 2.21486
[MF] GO:0043168 anion binding ALOX15, APP, AURKB, AXL, CSNK2A1, FABP3, FABP4, FLT3, HMGCR, HSD17B1, IGF1R, KDR, MET, PIM1, PTAFR, SLC1A1, SRC, TRPV1, XDH 2.21028
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIM1, SRC 2.20264
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD17B1, HSD17B2 2.18706
[MF] GO:0101020 estrogen 16-alpha-hydroxylase activity CYP1A1, CYP3A4 2.15948
[MF] GO:0042562 hormone binding ACHE, HSD17B1, IGF1R, NR3C1 2.0948
[MF] GO:0051879 Hsp90 protein binding CSNK2A1, KDR, NR3C1 2.07742
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP3A4 2.01674
[MF] GO:0004064 arylesterase activity CA1, CA2 2.01674


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 9.7158
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GRM3, GRIA2, GRM5, ADORA3, GRIK5, PTAFR, GRM8, ADORA1, TRPV1, NR3C1, GRM1, GRIA4 9.5864
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 8.7667
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, GRIA2, GRM5, GRIK5, GRM8, SLC1A1, GRM1, GRIA4 7.8153
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA14 9.7158
Metabolic pathways_Homo sapiens_hsa01100 CBR1, ALOX15, AKR1B1, ALOX12, HMGCR, TYR, CYP3A4, CYP19A1, HSD11B1, FUT7, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, XDH 5.923
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 6.1035
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1, CYP3A4 5.923
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, IGF1R 3.7149
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.2476
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, ALOX12 3.6115
Adherens junction_Homo sapiens_hsa04520 CSNK2A1, SRC, MET, IGF1R 3.3799
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.465
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, GRM1 2.9763
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 GRIA2, GRM5, GRM1, GRIA4 2.9694
Serotonergic synapse_Homo sapiens_hsa04726 APP, ALOX5, ALOX15, ALOX12 2.8447
Pathways in cancer_Homo sapiens_hsa05200 FLT3, MMP1, MMP2, MMP9, MET, IGF1R 2.4636
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, GRM8, GRM1 2.4734
Long-term depression_Homo sapiens_hsa04730 GRIA2, GRM1, IGF1R 2.4783
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.9559
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4 3.2698
Long-term potentiation_Homo sapiens_hsa04720 GRIA2, GRM5, GRM1 2.4362
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.2054
cAMP signaling pathway_Homo sapiens_hsa04024 GRIA2, ADORA1, PPARA, GRIA4 2.0931
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, CYP3A4 2.4371
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, IGF1R 2.0842
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, KDR, MET, IGF1R 2.0435
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, ALOX12, TRPV1 2.0516
Bile secretion_Homo sapiens_hsa04976 CA2, HMGCR, CYP3A4 2.3614
Gap junction_Homo sapiens_hsa04540 GRM5, SRC, GRM1 2.1314
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.7392
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, MMP9, MET 1.5815
Calcium signaling pathway_Homo sapiens_hsa04020 GRM5, PTAFR, GRM1 1.4408
Ras signaling pathway_Homo sapiens_hsa04014 KDR, MET, IGF1R 1.2431
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.4548
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.5039
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, PIM1 1.1487
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 1.1056
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.5003
Amphetamine addiction_Homo sapiens_hsa05031 GRIA2, GRIA4 1.4085
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.215
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.4085
Circadian entrainment_Homo sapiens_hsa04713 GRIA2, GRIA4 1.1892
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.39
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.4063
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 KDR, MET, IGF1R 0.9055
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.3222
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 1.0368
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2 1.5923
Dopaminergic synapse_Homo sapiens_hsa04728 GRIA2, GRIA4 0.9961
AMPK signaling pathway_Homo sapiens_hsa04152 HMGCR, IGF1R 1.0191
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 1.0419
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP1A2, CYP3A4 1.404
Hepatitis B_Homo sapiens_hsa05161 SRC, MMP9 0.9303
FoxO signaling pathway_Homo sapiens_hsa04068 GRM1, IGF1R 0.9801
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.9535
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1 0.8564
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP3A4, XDH 1.6334
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.7392
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1 0.3732
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.5369
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC 0.3615
Purine metabolism_Homo sapiens_hsa00230 XDH 0.4012
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.372
Taste transduction_Homo sapiens_hsa04742 GRM1 0.5369
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3917
Huntington's disease_Homo sapiens_hsa05016 GRM5 0.3848
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1 0.431
Prostate cancer_Homo sapiens_hsa05215 IGF1R 0.5369
Tuberculosis_Homo sapiens_hsa05152 SRC 0.4011
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.4393
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 IGF1R 0.4573
Alzheimer's disease_Homo sapiens_hsa05010 APP 0.4134
Measles_Homo sapiens_hsa05162 CSNK2A1 0.465
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.431
Insulin resistance_Homo sapiens_hsa04931 PPARA 0.5109
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.4573
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 IGF1R 0.5317
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3917
Platelet activation_Homo sapiens_hsa04611 SRC 0.4895
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5369
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.5109
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5369
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.469
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.5109
Melanogenesis_Homo sapiens_hsa04916 TYR 0.5291
HIF-1 signaling pathway_Homo sapiens_hsa04066 IGF1R 0.5261
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.5349
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4895
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.4966
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5369
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5291
Axon guidance_Homo sapiens_hsa04360 MET 0.4819
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5369
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5369
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.5722
Peroxisome_Homo sapiens_hsa04146 XDH 0.5369
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5 0.4966
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5349
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.5349
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5667
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5349
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5962
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.5369
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5779
Glioma_Homo sapiens_hsa05214 IGF1R 0.5962
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5957
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5962
Shigellosis_Homo sapiens_hsa05131 SRC 0.5962
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B1 0.6117
Staphylococcus aureus infection_Homo sapiens_hsa05150 PTAFR 0.6267
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2 0.6586
Malaria_Homo sapiens_hsa05144 MET 0.6686
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.1314
Galactose metabolism_Homo sapiens_hsa00052 AKR1B1 0.8389
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.7943
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8318
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B1 0.7891
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B1 0.8251
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8784
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8693
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 HMGCR 0.9303
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.2502


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)