Prescription Description
| Prescription ID | TCMF2143 |
| Pinyin Name | Qing Xin Lian Zi Yin |
| Chinese Name | 清心莲子饮 |
| English Name | Decoction of Nelumbinis for Eliminating Heart Fire |
| Function Description | 遗精, 消渴 |
| Indications | Involuntary ejaculation disorder, Wasting thirst disorder |
| Disease ICD-11 Category |
SB09 [Involuntary ejaculation disorder (TM1), 遗精 (TM1)
]; SD71 [Wasting thirst disorder (TM1), 消渴 (TM1) ]; |
| Human Tissues Associated with Indication | Kidney |
| Reference | Chinese Classical Prescriptions |
| Reference Book/link | ISBN 7-5023-3930-2 |
Prescription Components
| Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
|---|---|---|---|---|
| TCMH986 | Scutellaria baicalensis | 黄芩 | TCMH986 | ITSAP4211-14 |
| TCMH1423 | Ophiopogon japonicus | 麦冬 | TCMH1423 | ITSAJ4140-14 |
| TCMH449 | Cortex lycii radicis | 地骨皮 | TCMH449 | |
| TCMH241 | Plantago asiatica | 车前子 | TCMH241 | ITSAB3641-14 |
| TCMH981 | Astragalus membranaceus | 黄芪 | TCMH981 | ITSAK2981-14 |
| TCMH2059 | Radix pseudostellariae | 太子参 | TCMH2059 | |
| TCMH1275 | Nelumbo nucifera | 莲子 | TCMH1275 | ITSAI3109-14 |
| TCMH606 | Wolfiporia cocos | 茯苓 | TCMH606 | GBPOL314-13 |
| TCMH628 | Glycyrrhiza uralensis | 甘草 | TCMH628 | ITSAM892-14 |
Targeted Human Proteins by the Ingredients of Prescription
| Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
|---|---|---|---|---|
| TCMT100 | TTR | Transthyretin | Unclassified | P02766 |
| TCMT101 | PTPN1 | Protein-tyrosine phosphatase 1B | Hydrolase | P18031 |
| TCMT102 | ACP1 | Low molecular weight phosphotyrosine protein phosphatase | Hydrolase | P24666 |
| TCMT103 | PTPRF | Receptor-type tyrosine-protein phosphatase F (LAR) | Hydrolase | P10586 |
| TCMT112 | ADORA3 | Adenosine A3 receptor | GPCR | P0DMS8 |
| TCMT127 | PARP1 | Poly [ADP-ribose] polymerase-1 | Transferase | P09874 |
| TCMT128 | TNKS2 | Tankyrase-2 | Transferase | Q9H2K2 |
| TCMT129 | TNKS | Tankyrase-1 | Transferase | O95271 |
| TCMT13 | APEX1 | DNA-(apurinic or apyrimidinic site) lyase | Lyase | P27695 |
| TCMT130 | ALOX5 | Arachidonate 5-lipoxygenase | Oxidoreductase | P09917 |
Showing 1 to 10 of 107 entries
Targeted Pathogenic Microbes by the Ingredients of Prescription
| Target ID | Target Name |
|---|---|
| TCMT1170 | Enterobacter cloacae |
| TCMT1175 | Human immunodeficiency virus |
| TCMT1176 | Streptococcus pneumoniae |
| TCMT1178 | Actinomyces viscosus |
| TCMT1179 | Escherichia coli ATCC 8739 |
| TCMT1181 | Mycobacterium tuberculosis H37Ra |
| TCMT1186 | Plasmodium yoelii yoelii |
| TCMT1189 | Pseudomonas fluorescens |
| TCMT1191 | Bacillus megaterium |
| TCMT1208 | Escherichia coli K12 |
Showing 1 to 10 of 71 entries
Gene Ontology Associated to Targeted Human Proteins
| GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|---|
| [BP] GO:0000302 | response to reactive oxygen species | AKR1B1, APEX1, AXL, BCL2, CYP1B1, MMP9, SRC | 3.34345 |
| [BP] GO:0001503 | ossification | ALOX15, ALPL, BCL2, MMP2, MMP9 | 2.28167 |
| [BP] GO:0001666 | response to hypoxia | ADORA1, BCL2, CYP1A1, DRD2, HSD11B2, MMP2, PPARA, SRC | 3.2478 |
| [BP] GO:0001676 | long-chain fatty acid metabolic process | ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1 | 2.49398 |
| [BP] GO:0001932 | regulation of protein phosphorylation | ADORA1, ALOX15, BCL2, CDC25B, DRD2, FABP4, FLT3, HMGCR, IGF1R, KDR, MMP9, PRKCA, PTPN1, SRC, XDH | 2.20654 |
| [BP] GO:0001934 | positive regulation of protein phosphorylation | ADORA1, ALOX15, BCL2, CDC25B, DRD2, FLT3, HMGCR, KDR, MMP9, PRKCA, PTPN1, SRC, XDH | 2.58791 |
| [BP] GO:0002521 | leukocyte differentiation | AXL, BCL2, FLT3, FUT7, GLO1, MMP9, RORC | 2.39072 |
| [BP] GO:0002682 | regulation of immune system process | ADORA1, ALOX15, AXL, BCL2, CA2, CDK6, CYP19A1, DRD2, ESR1, ESRRA, MMP12, MMP2, PRKCA, PTPN1, PTPRS, SRC | 2.25422 |
| [BP] GO:0002683 | negative regulation of immune system process | ADORA1, ALOX15, AXL, CDK6, CYP19A1, DRD2, MMP12, PTPRS | 2.14754 |
| [BP] GO:0003014 | None | ADORA1, AKR1B1, BCL2, DRD2, HSD11B2 | 2.56696 |
Showing 1 to 10 of 273 entries
KEGG Pathways Associated to Targeted Human Proteins
| KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|
| ABC transporters_Homo sapiens_hsa02010 | ABCB1 | 0.634 |
| Acute myeloid leukemia_Homo sapiens_hsa05221 | FLT3, PIM1 | 1.3224 |
| Adherens junction_Homo sapiens_hsa04520 | PTPN1, CSNK2A1, SRC, MET, IGF1R | 3.9996 |
| Adipocytokine signaling pathway_Homo sapiens_hsa04920 | PPARA | 0.5414 |
| Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | BCL2, PRKCA | 0.7796 |
| African trypanosomiasis_Homo sapiens_hsa05143 | PRKCA | 0.7133 |
| AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | MMP2, BCL2, PIM1, PRKCA, F3 | 3.581 |
| Alcoholism_Homo sapiens_hsa05034 | DRD2 | 0.3341 |
| Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | PRKCA | 0.5013 |
| Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | HSD11B2, PRKCA | 1.5693 |
Showing 1 to 10 of 164 entries
Target Exprsssion in Healthy Human Tissues (protein & mRNA level)
Protein expression data was from the "Human Proteome Map" datasetmRNA expression data was from the "GTEx" dataset
Average Target Expression (Fold Change) in Multiple Disease Conditions
Fold Change with Corresponding Normal SamplesClick each cell within the heatmap to access gene expression of individual patient samples