TCM Prescription: Da Hu Zhuang Yuan Pills



Prescription Description
Prescription IDTCMF3700
Pinyin NameDa Hu Zhuang Yuan Wan
Chinese Name打虎壮元丸
English NameDa Hu Zhuang Yuan Pills
Function Description腰痛, 健忘, 不寐, 阳痿, 早泄
IndicationsPremature ejaculation disorder, Impotence disorder, Lumbago disorder, Forgetfulness disorder, Insomnia disorder, Insomnia, Sexual dysfunction, Lumbago, Premature ejaculation
Disease ICD-11 Category SB08 [Premature ejaculation disorder (TM1), 早泄 (TM1) ];
SB0B [Impotence disorder (TM1), 阳痿 (TM1) ];
SC61 [Lumbago disorder (TM1), 腰痛 (TM1) ];
SD23 [Forgetfulness disorder (TM1), 健忘 (TM1) ];
SD84 [Insomnia disorder (TM1), 不寐 (TM1) ];
7A0Z [Insomnia disorders, unspecified, 失眠障碍，未特指的 ];
HA0Z [Sexual dysfunctions, unspecified, 性功能障碍，未特指的 ];
ME84.2Z [Low back pain, unspecified, 下腰痛，未特指的 ];
HA03.0Z [Male early ejaculation, unspecified, 男性早泄，未特指的 ];
Human Tissues Associated with IndicationHeart, Brain, Kidney, Bladder
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1811 Semen astragali complanati 沙苑子 TCMH1811
TCMH1024 Tribulus terrestris 蒺藜 TCMH1024 ITSAJ4258-14
TCMH2084 Asparagus cochinchinensis 天冬 TCMH2084 ITSAJ4142-14
TCMH1866 Cnidium monnieri 蛇床子 TCMH1866 ITSAL2575-14
TCMH1518 Chaenomeles sinensis 木瓜 TCMH1518 GBVJ2053-11, GBVJ2052-11
TCMH136 Os pardi 豹骨 TCMH136
TCMH289 Cyathula officinalis 川牛膝 TCMH289 ITSAF2788-14
TCMH2202 Schisandra chinensis 五味子 TCMH2202 ITSAM2867-14
TCMH524 Eucommia ulmoides 杜仲 TCMH524 ITSAM1588-14
TCMH1533 Saussurea lappa 木香 TCMH1533
TCMH31 Morinda officinalis 巴戟天 TCMH31 ITSAJ4459-14
TCMH1186 Lycium chinense 枸杞子 TCMH1186 ITSAO4545-14
TCMH2052 Ziziphus jujuba var. spinosa 酸枣仁 TCMH2052 ITSAM943-14
TCMH1966 Rehmannia glutinosa 熟地黄 TCMH1966 ITSAH4578-14
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH449 Cortex lycii radicis 地骨皮 TCMH449
TCMH1803 Amomum villosum 砂仁 TCMH1803 ITSAD521-14
TCMH1423 Ophiopogon japonicus 麦冬 TCMH1423 ITSAJ4140-14
TCMH451 Rehmannia glutinosa 地黄 TCMH451 ITSAH4578-14
TCMH2554 Polygala tenuifolia 远志 TCMH2554 MF096619
TCMH1740 Cistanche deserticola 肉苁蓉 TCMH1740 ITSAM2511-14
TCMH541 Colla corii asini 阿胶 TCMH541
TCMH611 Rubus idaeus 覆盆子 TCMH611 ITSAE336-14
TCMH924 Zanthoxylum bungeanum 花椒 TCMH924 ITSAJ4650-14
TCMH1742 Cinnamomum cassia 肉桂 TCMH1742 GQ255631
TCMH241 Plantago asiatica 车前子 TCMH241 ITSAB3641-14
TCMH623 Aconitum carmichaeli 附子 TCMH623 ITSAH2410-14
TCMH2581 Alisma orientale 泽泻 TCMH2581 KC573871
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH1920 Acorus tatarinowii 石菖蒲 TCMH1920 ITSAI4409-14
TCMH1845 Dioscorea batatas 山药 TCMH1845
TCMH296 Radix aconiti 川乌 TCMH296
TCMH259 Halloysitum rubrum 赤石脂 TCMH259
TCMH193 Psoralea corylifolia 补骨脂 TCMH193
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT107 GRIK2 Glutamate receptor ionotropic kainate 2 Ion channel Q13002
TCMT109 GRIA2 Glutamate receptor ionotropic, AMPA 2 Ion channel P42262
TCMT110 GRIA4 Glutamate receptor ionotropic, AMPA 4 Ion channel P48058
TCMT111 GRIK5 Glutamate receptor ionotropic kainate 5 Ion channel Q16478
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT151 PRKCA Protein kinase C alpha Kinase P17252
TCMT152 PRKCB Protein kinase C beta Kinase P05771
TCMT153 PRKCG Protein kinase C gamma Kinase P05129
TCMT154 PRKCD Protein kinase C delta Kinase Q05655
TCMT155 PRKCE Protein kinase C epsilon Kinase Q02156
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT213 SLC22A1 Solute carrier family 22 member 1 Transporter O15245
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT237 SLC5A1 Sodium/glucose cotransporter 1 Transporter P13866
TCMT238 SLC5A2 Sodium/glucose cotransporter 2 Transporter P31639
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT290 CHRM5 Muscarinic acetylcholine receptor M5 GPCR P08912
TCMT291 CHRM3 Muscarinic acetylcholine receptor M3 GPCR P20309
TCMT292 CHRM1 Muscarinic acetylcholine receptor M1 GPCR P11229
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT302 HMGCR HMG-CoA reductase Oxidoreductase P04035
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT309 SLC22A2 Solute carrier family 22 member 2 Transporter O15244
TCMT310 SLC47A2 Multidrug and toxin extrusion protein 2 Transporter Q86VL8
TCMT311 SLC47A1 Multidrug and toxin extrusion protein 1 Transporter Q96FL8
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT355 CSNK1D Casein kinase I delta Kinase P48730
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT417 DYRK2 Dual-specificity tyrosine-phosphorylation regulated kinase 2 Kinase Q92630
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT458 HASPIN Serine/threonine-protein kinase haspin Kinase Q8TF76
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT473 PIM3 Serine/threonine-protein kinase PIM3 Kinase Q86V86
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT594 PTAFR Platelet activating factor receptor GPCR P25105
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT608 SLC22A3 Solute carrier family 22 member 3 Transporter O75751
TCMT613 NR3C1 Glucocorticoid receptor Nuclear receptor P04150
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT619 HSP90AA1 Heat shock protein HSP 90-alpha Unclassified P07900
TCMT624 HSP90AB1 Heat shock protein HSP 90-beta Unclassified P08238
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT653 GRM1 Metabotropic glutamate receptor 1 GPCR Q13255
TCMT654 GRM5 Metabotropic glutamate receptor 5 GPCR P41594
TCMT655 GRM2 Metabotropic glutamate receptor 2 GPCR Q14416
TCMT656 GRM3 Metabotropic glutamate receptor 3 GPCR Q14832
TCMT657 GRM4 Metabotropic glutamate receptor 4 GPCR Q14833
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT660 GRM8 Metabotropic glutamate receptor 8 GPCR O00222
TCMT664 SLC1A1 Excitatory amino acid transporter 3 Transporter P43005
TCMT67 PPARG Peroxisome proliferator-activated receptor gamma Nuclear receptor P37231
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT726 BCR Bcr/Abl fusion protein Kinase P11274
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT751 DYRK1A Dual-specificity tyrosine-phosphorylation regulated kinase 1A Kinase Q13627
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT763 DYRK3 Dual-specificity tyrosine-phosphorylation regulated kinase 3 Kinase O43781
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT81 ALOX12 Arachidonate 12-lipoxygenase Oxidoreductase P18054
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT814 CLK1 Dual specificty protein kinase CLK1 Kinase P49759
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT829 NISCH Nischarin Unclassified Q9Y2I1
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT831 DYRK4 Dual specificity tyrosine-phosphorylation-regulated kinase 4 Kinase Q9NR20
TCMT832 DYRK1B Dual specificity tyrosine-phosphorylation-regulated kinase 1B Kinase Q9Y463
TCMT847 SLC5A4 Low affinity sodium-glucose cotransporter Transporter Q9NY91
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1186 Plasmodium yoelii yoelii
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1250 Vesicular stomatitis virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1257 Colletotrichum lagenarium
TCMT1282 Colletotrichum orbiculare
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1353 Plasmodium yoelii
TCMT1354 Streptococcus mutans UA159
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1390 Human herpesvirus 2 strain G
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APEX1, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CHRM1, CHRM3, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD3, EGFR, ESR1, F3, FABP3, FABP4, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM5, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, INSR, KDR, MAOA, MET, NISCH, PIK3CA, PIK3CB, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PTAFR, PTGS1, PTGS2, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1, XDH 18.6151
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, APEX1, AXL, BCL2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, EGFR, ESR1, ESRRA, FABP3, GRIK5, GRM5, HMGCR, HSD11B2, HSD17B2, HSP90AB1, IGF1R, INSR, MMP2, MMP9, NR3C1, PIK3CA, PPARA, PPARG, PRKCB, PRKCD, PRKCE, PTAFR, PTGS2, RORC, SRC, TEK, TRPV1, TYR 15.1305
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, APEX1, AXL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSD11B2, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MMP2, NR3C1, PIK3CA, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS2, RORC, SMAD3, SRC, TEK, TRPV1, TYR 15.0925
[BP] GO:0042221 response to chemical AKR1B1, ALOX15, ALPL, APEX1, AXL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, EGFR, ESR1, ESRRA, FABP3, FABP4, FLT3, GRIK5, GRM5, HMGCR, HSD11B2, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, PIK3CA, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS2, RORC, SMAD3, SRC, TEK, TRPV1, TYR 12.1493
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, ALOX12, APEX1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, DYRK3, EGFR, ESR1, F3, FLT3, GLO1, GRIK5, HCAR2, HMGCR, HSP90AB1, HSPA1A, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARG, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 11.3603
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, ALOX12, APEX1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, DYRK3, EGFR, ESR1, F3, FLT3, GLO1, GRIK5, HCAR2, HMGCR, HSP90AB1, HSPA1A, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 11.054
[BP] GO:0014070 response to organic cyclic compound ALPL, APEX1, BCL2, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, EGFR, ESR1, ESRRA, FLT3, HSD11B2, HSP90AB1, NR3C1, PPARG, PRKCE, PRKCG, PTAFR, PTGS2, RORC, SRC, TEK, TRPV1, TYR 10.8839
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, ALOX12, APEX1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, DYRK3, EGFR, ESR1, F3, FLT3, GLO1, GRIK5, HCAR2, HMGCR, HSP90AB1, HSPA1A, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PIM1, PPARG, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 10.8839
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APEX1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD3, DUSP3, DYRK1A, DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GPR35, GRIK5, GRM1, GRM5, HCAR2, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, XDH 10.2531
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, CLK1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, PRKCD, SRC, TEK 10.2344
[BP] GO:0018212 peptidyl-tyrosine modification AXL, CLK1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, PRKCD, SRC, TEK 10.171
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, ESR1, FABP3, FABP4, FUT7, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MET, PIK3CA, PIK3CB, PPARA, PPARG, PTGS1, PTGS2, TRPV1 10.1587
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CDC25B, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSP90AA1, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TNKS 9.98436
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 9.88475
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD3, DUSP3, DYRK1A, DYRK2, DYRK3, EGFR, ESR1, ESR2, F3, FLT3, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NISCH, NUAK1, PIK3CA, PIK3CB, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 9.53672
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, APEX1, AURKB, AXL, BCL2, CDC25B, CDK6, CLK1, CSNK2A1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HMGCR, HSP90AA1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS2, PTPN1, SRC, TEK, TNKS, XDH 9.5282
[BP] GO:0009725 response to hormone AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, INSR, NR3C1, PPARA, PPARG, PRKCD, PRKCE, PTAFR, PTGS2, SRC, TEK, TRPV1 9.50836
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CDK6, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, NR3C1, PPARG, PRKCE, PTAFR, PTGS2, RORC, SRC, TYR 9.50836
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, ALOX12, ALOX15, APEX1, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CHRM1, CHRM3, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD3, DUSP3, DYRK1A, DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GPR35, GRIK5, GRM1, GRM5, HCAR2, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NR3C1, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS2, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, XDH 9.41677
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD3, DUSP3, DYRK1A, DYRK2, DYRK3, EGFR, ESR1, ESR2, F3, FLT3, GPR35, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NISCH, NUAK1, PIK3CA, PIK3CB, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 9.41677
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, BCL2, CA9, CDK6, CNR1, CNR2, CYP1A1, CYP1B1, DRD3, EGFR, FABP3, HMGCR, HSD11B2, HSP90AB1, KDR, NR3C1, PPARG, PRKCD, PRKCE, PRKCG, PTAFR, PTGS2, SRC, TRPV1 9.38602
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, ALOX15, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD3, EGFR, F3, FLT3, GPR35, GRM1, HCAR2, HMGCR, HSP90AB1, HSPA1A, INSR, KDR, MET, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 9.33201
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM3, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD3, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HASPIN, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MAOA, MET, MMP1, MMP2, MMP9, NISCH, NQO2, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS1, PTGS2, PTPN1, RORC, SLC22A2, SLC5A2, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 9.30524
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, ALOX15, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD3, EGFR, F3, FLT3, GPR35, GRM1, HCAR2, HMGCR, HSP90AB1, HSPA1A, INSR, KDR, MET, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 9.29882
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 9.26768
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ALOX12, ALOX15, APEX1, AXL, BCL2, CA2, CA7, CDK6, CHRM1, CNR1, CSNK2A1, CYP19A1, CYP1B1, DRD3, DYRK2, EGFR, F3, GPR35, GRIK5, GRM5, HCAR2, HMGCR, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NISCH, PIK3CB, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, TRPV1 9.09607
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, APEX1, AURKB, AXL, BCL2, CDC25B, CDK6, CLK1, CSNK2A1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HMGCR, HSP90AA1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS2, PTPN1, SRC, TEK, TNKS, XDH 9.07578
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, APEX1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, ESRRA, FABP3, FLT3, GRM5, HSD11B2, IGF1R, INSR, MMP2, NR3C1, PPARA, PPARG, PRKCD, PRKCE, PTAFR, PTGS2, SMAD3, SRC, TEK, TRPV1 8.95526
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, FABP3, FUT7, GBA2, GLO1, HMGCR, HSPA1A, NISCH, PIK3CA, PIM1, PPARA, PPARG, PTAFR, PTGS1, PTGS2, TYR, XDH 8.893
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, APEX1, AXL, BCL2, CDK6, CYP1A1, CYP1B1, EGFR, ESR1, FABP4, FLT3, GRIK5, GRM5, HSP90AB1, IGF1R, INSR, KDR, MMP2, NR3C1, PIK3CA, PPARG, PRKCB, PRKCD, PRKCE, PTAFR, PTGS2, RORC, SMAD3, SRC, TRPV1 8.89042
[BP] GO:0016310 phosphorylation AURKB, AXL, BCL2, CDC25B, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSP90AA1, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TNKS 8.77639
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, DYRK3, EGFR, GLO1, HMGCR, HSP90AB1, HSPA1A, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK 8.70492
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, APEX1, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, GRIK5, GRM5, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, PIK3CA, PPARG, PRKCB, PRKCD, PRKCE, PTAFR, PTGS2, RORC, SMAD3, SRC, TRPV1 8.70492
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, DYRK3, EGFR, GLO1, HMGCR, HSP90AB1, HSPA1A, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PPARA, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK 8.58388
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, CNR1, CNR2, DRD3, EGFR, FABP3, FLT3, GRM5, HSD11B2, HSP90AB1, IGF1R, INSR, MMP2, PPARA, PPARG, PRKCD, PRKCE, PRKCG, PTAFR, PTGS2, SRC, TEK, TRPV1, TYR 8.40644
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD3, DUSP3, DYRK1A, DYRK2, DYRK3, EGFR, ESR1, F3, FLT3, GPR35, GRM1, HMGCR, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 8.20721
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD3, FABP3, PPARA, PPARG, SLC1A1, SLC22A1, SLC22A2, SLC22A3, TRPV1 8.19035
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, ALOX12, AURKB, AXL, BCL2, CSNK2A1, DYRK3, EGFR, GLO1, HMGCR, HSP90AB1, HSPA1A, IGF1R, KDR, MMP9, PIK3CA, PIM1, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK 8.12585
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, AXL, BCL2, CA1, CA2, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CNR1, CNR2, CSNK2A1, CYP1B1, DRD3, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HASPIN, HCAR2, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MET, MMP2, MMP9, NISCH, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1 8.02215
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, TYR 7.98693
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSP90AA1, IGF1R, INSR, KDR, MET, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TNKS, TOP2A 7.90867
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, ALOX15, AXL, BCL2, CSNK2A1, CYP1B1, DRD3, EGFR, F3, FLT3, GPR35, GRM1, HMGCR, HSP90AB1, HSPA1A, INSR, KDR, MET, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 7.87869
[BP] GO:0007193 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, DRD3, GRM1, GRM3, GRM5, GRM8 7.8069
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, ESR1, GBA2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 7.8069
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, ALOX15, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, DRD3, EGFR, ESRRA, F3, FABP4, FLT3, GPR35, GRM1, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 7.8069
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, ALOX12, APEX1, BCL2, CDK6, CHRM1, CYP19A1, CYP1B1, DRD3, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, NISCH, PPARG, PRKCA, PRKCE, PTAFR, PTGS2, SMAD3, SRC, TEK 7.8069
[BP] GO:0019369 arachidonic acid metabolic process ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 7.8069
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, CNR1, CNR2, DRD3, EGFR, FABP3, FLT3, GRM5, HSD11B2, HSP90AB1, IGF1R, INSR, MMP2, PPARA, PPARG, PRKCD, PRKCE, PRKCG, PTAFR, PTGS2, SRC, TEK, TRPV1, TYR 7.8069
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, APEX1, AXL, CDK6, CYP1B1, EGFR, ESR1, GRIK5, GRM5, IGF1R, INSR, MMP2, MMP9, NR3C1, PIK3CA, PPARG, PRKCB, PRKCD, PRKCE, PTAFR, PTGS2, RORC, SRC, TRPV1 7.8069
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, ALOX12, APEX1, AXL, BCL2, CA12, CA2, CA7, CNR1, DRD3, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, GRIK5, GRM1, GRM5, HSP90AA1, HSP90AB1, INSR, MET, PIK3CA, PIK3CB, PPARG, PRKCB, PRKCE, SMAD3, SRC, TRPV1 7.8069
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM3, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD3, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HASPIN, HMGCR, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MAOA, MET, MMP1, MMP2, NQO2, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS1, PTGS2, PTPN1, RORC, SLC22A2, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TYR, XDH 7.79256
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MAOA, NQO2, PPARG, PTGS1, PTGS2, TYR, XDH 7.79256
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, ALOX12, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, CYP1B1, DRD3, EGFR, ESR1, ESRRA, F3, FABP3, FLT3, HMGCR, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, PIM1, PPARG, PRKCA, PTAFR, PTGS1, PTGS2, SMAD3, SRC, TEK, XDH 7.71275
[BP] GO:0080134 regulation of response to stress ADORA1, ALOX12, CDK6, CNR1, CNR2, CYP19A1, DUSP3, DYRK1A, DYRK3, EGFR, ESR1, F3, FABP4, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, MET, MMP2, NUAK1, PPARA, PPARG, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 7.69327
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ALOX15, AURKB, BCL2, CDC25B, CSNK2A1, DRD3, DYRK1A, DYRK1B, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRM1, GRM5, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NR3C1, PIK3CA, PIK3CB, PPARA, PPARG, PRKCA, PRKCD, PRKCE, PRKCG, PTAFR, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, XDH 7.68736
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD3, EGFR, GRIK5, HSP90AA1, HSP90AB1, INSR, MAOA, PTGS2, SLC1A1, SLC22A2, SLC22A3, SMAD3, TRPV1 7.68736
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, CA2, CA7, CNR1, CNR2, DRD3, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8, NISCH, PRKCE, PTGS2 7.68736
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, CA2, CA7, CNR1, CNR2, DRD3, EGFR, GRIK5, GRM1, GRM3, GRM5, GRM8, NISCH, PRKCE, PTGS2 7.68736
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ALOX15, AURKB, BCL2, CDC25B, DRD3, DYRK1A, DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GRM1, GRM5, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NR3C1, PIK3CA, PIK3CB, PPARA, PPARG, PRKCA, PRKCD, PRKCE, PRKCG, PTAFR, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, XDH 7.68736
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, BCL2, CDC25B, CHRM5, DRD3, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, HSP90AB1, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 7.66574
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ALOX15, BCL2, CDC25B, CHRM5, DRD3, DUSP3, EGFR, ESRRB, FABP3, FABP4, FLT3, GRM1, GRM3, GRM5, GRM8, HMGCR, HSP90AB1, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 7.57317
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CHRM5, CNR1, CYP1A1, DRD3, FABP3, FLT3, HCAR2, HMGCR, PPARA, PPARG, PRKCD, PRKCE, PTGS2, RORC, SRC, TEK 7.46983
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CDK6, CNR1, DRD3, EGFR, HCAR2, HMGCR, KDR, PIK3CB, PRKCE, PTGS2, SRC, TNKS, TNKS2, TRPV1 7.43267
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, AXL, BCL2, CA1, CSNK2A1, DYRK2, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTAFR, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1 7.41363
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CDK6, CYP1B1, EGFR, HSP90AB1, KDR, NR3C1, PRKCD, PRKCE, PTAFR, PTGS2, SRC, TRPV1 7.15402
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, ALOX12, APEX1, BCL2, CDK6, CYP19A1, CYP1B1, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, NISCH, PPARG, PRKCA, PRKCE, PTAFR, PTGS2, SMAD3, SRC, TEK 7.15354
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ALOX15, AURKB, BCL2, CDC25B, CSNK2A1, DRD3, DYRK1A, DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GRM1, GRM5, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NR3C1, PIK3CA, PIK3CB, PPARA, PPARG, PRKCA, PRKCD, PRKCE, PRKCG, PTAFR, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, XDH 7.12591
[BP] GO:0046777 protein autophosphorylation AURKB, CLK1, CSNK2A1, DYRK1A, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, PRKCG, SRC, TEK 7.12359
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, AXL, BCL2, CYP1B1, EGFR, F3, FLT3, GPR35, GRM1, HMGCR, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 7.10626
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ALOX15, AURKB, BCL2, CDC25B, CSNK2A1, DRD3, DYRK1A, DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, GRM1, GRM5, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NR3C1, PIK3CA, PIK3CB, PPARA, PPARG, PRKCA, PRKCD, PRKCE, PRKCG, PTAFR, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, XDH 7.00533
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CNR1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, EGFR, ESR1, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PRKCA, PRKCE, SLC22A1 7.00533
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, ALOX12, APEX1, BCL2, CYP19A1, CYP1B1, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, NISCH, PPARG, PRKCA, PRKCE, PTAFR, PTGS2, SMAD3, SRC, TEK 6.97643
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ALOX15, AXL, BCL2, CA2, CA7, CHRM1, CNR1, CYP19A1, DRD3, DYRK2, EGFR, GPR35, GRIK5, GRM5, HCAR2, HMGCR, HSP90AB1, HSPA1A, INSR, MMP9, PIK3CB, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TRPV1 6.97045
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 6.9588
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, BCL2, CA2, CYP1A1, DRD3, EGFR, GRM1, HMGCR, HSD11B2, HSP90AA1, HSP90AB1, HSPA1A, MMP2, PPARA, PPARG, PRKCB, PRKCE, PTAFR, PTGS2, SMAD3, SRC, TEK, TRPV1, TYR 6.89959
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AXL, BCL2, CHRM1, CHRM3, CHRM5, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESRRB, F3, FABP4, GRM1, GRM5, GRM8, HMGCR, HSD11B2, HSD17B2, IGF1R, INSR, MET, MMP1, MMP2, MMP9, PIK3CA, PIM1, PPARA, PRKCD, PRKCG, PTAFR, PTGS2, RORC, SLC5A1, SMAD3, SRC, TEK, TNKS2, TRPV1, TYR 6.89537
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA6, CA9, CDK6, CHRM2, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, DYRK2, EGFR, ESR1, ESRRA, F3, FABP3, FABP4, FLT3, GRIK5, GRM1, GRM5, HMGCR, HSD11B2, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, NUAK1, PIK3CA, PIK3CB, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, TYR 6.84107
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, ALOX12, ALOX15, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD3, DUSP3, DYRK1A, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, F3, FABP4, FLT3, GPR35, GRM1, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 6.79546
[BP] GO:0048878 chemical homeostasis AKR1B1, ALOX12, BCL2, CA12, CA2, CA7, CNR1, DRD3, EGFR, ESR1, FABP3, FABP4, GPR35, GRIK5, GRM1, GRM5, INSR, MET, PIK3CA, PIK3CB, PPARG, PRKCB, PRKCE, SMAD3, TRPV1 6.75586
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ALOX15, BCL2, CDC25B, EGFR, ESRRB, FABP3, FLT3, GRM1, GRM5, HMGCR, HSP90AB1, INSR, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 6.75259
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ALOX15, BCL2, CDC25B, EGFR, ESRRB, FABP3, FLT3, GRM1, GRM5, HMGCR, HSP90AB1, INSR, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 6.75259
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, CNR1, CNR2, NISCH, PRKCE 6.74051
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, DRD3, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, GRM1, GRM3, GRM5, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, MMP9, NUAK1, PIK3CA, PIK3CB, PPARG, PRKCA, PRKCD, PRKCE, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 6.74051
[BP] GO:0006690 icosanoid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 6.71026
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, DYRK2, EGFR, ESR1, FABP4, FLT3, GRIK5, GRM1, GRM5, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NR3C1, NUAK1, PIK3CA, PPARG, PRKCB, PRKCD, PRKCE, PTAFR, PTGS2, PTPN1, RORC, SMAD3, SRC, TOP2A, TRPV1 6.64436
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX12, ALOX15, ALOX5, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, FABP3, FABP4, FUT7, GBA2, HMGCR, MET, PIK3CA, PIK3CB, PPARA, PPARG, PTGS1, PTGS2 6.60227
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, DRD3, FABP3, PPARA, PPARG, SLC1A1, SLC22A1, SLC22A2, SLC22A3, TRPV1 6.5958
[BP] GO:0018107 peptidyl-threonine phosphorylation BCL2, CLK1, CSNK2A1, DYRK1A, HASPIN, PRKCA, PRKCB, PRKCD, TNKS 6.58957
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, ALOX12, APEX1, BCL2, CDK6, CYP19A1, CYP1B1, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, NISCH, PPARG, PRKCA, PRKCE, PTAFR, PTGS2, SMAD3, SRC, TEK 6.56224
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM5, DRD3, FABP3, GRIA2, GRIA4, GRIK5, PPARA, PPARG, PRKCB, PRKCE, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC5A1, SLC5A2, SLC5A4, TRPV1 6.51406
[BP] GO:0007187 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, CNR1, CNR2, DRD3, GRM1, GRM3, GRM5, GRM8 6.49832
[BP] GO:0008217 None ADORA1, CNR1, DRD3, HSD11B2, NISCH, PPARA, PPARG, PTAFR, PTGS1, PTGS2, SMAD3 6.35869
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, APEX1, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD3, DUSP3, DYRK1A, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GPR35, GRM3, GRM8, HMGCR, HSP90AB1, HSPA1A, IGF1R, KDR, MET, MMP9, NISCH, NR3C1, PIK3CA, PIM1, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, XDH 6.35487
[BP] GO:0018210 peptidyl-threonine modification BCL2, CLK1, CSNK2A1, DYRK1A, HASPIN, PRKCA, PRKCB, PRKCD, TNKS 6.27847
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, CNR1, EGFR, GRM1, GRM3, GRM5, GRM8, PTGS2 6.267
[BP] GO:0007188 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, CNR1, DRD3, GRM1, GRM3, GRM5, GRM8 6.17328
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CNR1, CNR2, CYP1A1, CYP1B1, DRD3, HMGCR, HSP90AA1, KDR, PRKCD, PRKCE, SRC 6.10927
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, HSP90AA1, HSP90AB1, INSR, PRKCD, PTGS2, SMAD3, TRPV1, XDH 6.08662
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, APEX1, AURKB, AXL, BCL2, CDK6, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD3, DUSP3, DYRK1A, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, GLO1, GPR35, GRM3, GRM8, HCAR2, HMGCR, HSP90AB1, HSPA1A, IGF1R, KDR, MET, MMP9, NISCH, NR3C1, PIK3CA, PIM1, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, XDH 6.08444
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, APEX1, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, HSP90AB1, NR3C1, PPARG, PTAFR, PTGS2, RORC, SRC, TRPV1 6.04233
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, HSP90AA1, HSP90AB1, INSR, PTGS2, SMAD3, TRPV1 6.03305
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, HSP90AA1, HSP90AB1, INSR, PTGS2, SMAD3, TRPV1 6.03305
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, ALOX12, BCL2, CDC25B, CDK6, CHRM1, CSNK2A1, DRD3, EGFR, ESR1, F3, FLT3, HMGCR, IGF1R, INSR, KDR, MMP2, MMP9, PIM1, PRKCA, PTAFR, PTGS2, TEK 6.00156
[BP] GO:0007197 None CHRM1, CHRM2, CHRM3, CHRM5 5.96764
[BP] GO:0018105 peptidyl-serine phosphorylation AURKB, BCL2, CLK1, DYRK1A, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TNKS 5.95557
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, ALOX12, AXL, BCL2, CA2, CDK6, CHRM1, CHRM2, CHRM3, CNR1, CYP1B1, DRD3, EGFR, ESR1, ESRRA, ESRRB, F3, GPR35, GRM1, HCAR2, HMGCR, HSP90AB1, HSPA1A, INSR, KDR, MET, MMP9, PIK3CA, PIM1, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PTAFR, PTGS2, SLC1A1, SMAD3, SRC, TEK, TNKS2, TRPV1, XDH 5.94846
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ALOX12, ALOX15, BCL2, CDK6, CNR1, CNR2, CYP19A1, DRD3, DUSP3, DYRK1A, DYRK3, EGFR, ESR1, ESR2, HMGCR, HSPA1A, IGF1R, MET, MMP9, PPARA, PPARG, PRKCB, PRKCD, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.91484
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, CYP1B1, DRD3, DUSP3, EGFR, ESR1, ESR2, F3, FABP4, FLT3, GPR35, GRM1, GRM3, GRM5, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TRPV1, XDH 5.87384
[BP] GO:2000377 regulation of reactive oxygen species metabolic process BCL2, CYP1B1, EGFR, HSP90AA1, HSP90AB1, INSR, PRKCD, PTGS2, SMAD3, TRPV1, XDH 5.86063
[BP] GO:0007215 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 5.83918
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, BCL2, CDC25B, EGFR, ESRRB, FLT3, GRM1, GRM5, HMGCR, HSP90AB1, INSR, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 5.79941
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX12, ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 5.72739
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, DRD3, DUSP3, ESR1, FABP4, GPR35, GRM3, HMGCR, IGF1R, MET, MMP9, PIM1, PPARA, PPARG, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TNKS 5.70572
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ALOX15, BCL2, CDC25B, CSNK2A1, DYRK1A, EGFR, ESR1, F3, FLT3, GRM1, GRM5, HMGCR, HSP90AB1, HSPA1A, INSR, KDR, MMP9, PIK3CA, PIK3CB, PPARG, PRKCA, PRKCD, PRKCE, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.6756
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ALOX15, BCL2, CDC25B, DYRK1A, EGFR, ESR1, F3, FLT3, GRM1, GRM5, HMGCR, HSP90AB1, HSPA1A, INSR, KDR, MMP9, PIK3CA, PIK3CB, PPARG, PRKCA, PRKCD, PRKCE, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 5.64431
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, ALPL, APEX1, AURKB, AXL, BCL2, CA2, CA9, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, DYRK1A, DYRK1B, DYRK3, EGFR, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, GLO1, HMGCR, HSD11B1, HSD17B2, HSP90AB1, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PRKCA, PRKCD, PTGS2, RORC, SMAD3, SRC, TEK, TNKS2, TOP2A, TYR 5.60465
[BP] GO:0030335 positive regulation of cell migration ALOX12, BCL2, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, PTAFR, PTGS2, SMAD3, SRC, TEK 5.60465
[BP] GO:0032101 regulation of response to external stimulus ADORA1, ALOX12, CNR1, CNR2, CYP19A1, DRD3, EGFR, ESR1, F3, FABP4, HMGCR, KDR, MET, PPARA, PPARG, PRKCA, PRKCD, PRKCG, PTGS2, SMAD3, TEK 5.59151
[BP] GO:0007207 None CHRM1, CHRM2, CHRM3, CHRM5 5.54286
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, BCL2, CDC25B, EGFR, FLT3, GRM1, GRM5, HMGCR, HSP90AB1, INSR, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 5.52045
[BP] GO:0018209 peptidyl-serine modification AURKB, BCL2, CLK1, DYRK1A, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TNKS 5.5185
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 5.49665
[BP] GO:0051937 None CHRM5, NISCH, SLC22A1, SLC22A2, SLC22A3 5.48821
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CHRM3, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD3, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HASPIN, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MAOA, MET, MMP1, MMP2, MMP9, NISCH, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS1, PTGS2, PTPN1, RORC, SLC5A2, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 5.48821
[BP] GO:0009410 None CNR1, CNR2, DRD3, EGFR, HSP90AB1, NR3C1, PPARG, PRKCE, PRKCG, PTAFR 5.44005
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DRD3, DYRK1A, EGFR, ESR1, PPARA, PPARG, PRKCG, RORC, SRC, TOP2A 5.44005
[BP] GO:2000147 positive regulation of cell motility ALOX12, BCL2, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, PTAFR, PTGS2, SMAD3, SRC, TEK 5.41959
[BP] GO:0030168 platelet activation AXL, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 5.4133
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, HSP90AA1, HSP90AB1, INSR, PTGS2, SMAD3, TRPV1 5.37677
[BP] GO:0010676 None DYRK2, ESRRB, INSR, PPARA, PRKCE, PTAFR, SRC 5.37677
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, APEX1, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, MMP9, PRKCD, PTGS2, SRC 5.37677
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PPARG, PRKCB, PRKCE, PTGS2, SMAD3, SRC, TEK 5.33458
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CHRM3, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, HASPIN, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NISCH, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC5A2, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 5.29848
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4, HSP90AB1, NQO2, PTGS1, RORC 5.29628
[BP] GO:1901652 response to peptide AKR1B1, APEX1, FABP3, GRM5, HSD11B2, IGF1R, INSR, PPARA, PPARG, PRKCD, PTGS2, SRC, TEK, TRPV1 5.29175
[BP] GO:0051272 positive regulation of cellular component movement ALOX12, BCL2, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, PTAFR, PTGS2, SMAD3, SRC, TEK 5.27715
[BP] GO:0006631 fatty acid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, PPARA, PPARG, PTGS1, PTGS2 5.26149
[BP] GO:1901568 fatty acid derivative metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, PTGS1, PTGS2 5.2338
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX12, ALOX15, BCL2, CYP19A1, CYP1A1, CYP1B1, CYP3A4, DRD3, GBA2, HMGCR, MAOA, PTAFR, TYR 5.22349
[BP] GO:0099536 None CHRM1, CHRM2, CHRM3, CHRM5, CNR1, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, PRKCG, SLC1A1 5.22349
[BP] GO:0099537 None CHRM1, CHRM2, CHRM3, CHRM5, CNR1, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, PRKCG, SLC1A1 5.22349
[BP] GO:0009894 regulation of catabolic process ADORA1, APEX1, BCL2, CNR1, CSNK2A1, EGFR, ESRRB, HCAR2, HSP90AB1, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3 5.18274
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD3, DUSP3, DYRK1A, DYRK2, DYRK3, EGFR, ESR1, ESR2, F3, FLT3, GPR35, GRM1, HMGCR, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, XDH 5.16274
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, HSP90AA1, HSP90AB1, INSR, PTGS2, SMAD3, TRPV1 5.13957
[BP] GO:0051240 positive regulation of multicellular organismal process ALOX12, AXL, BCL2, CA2, CHRM3, CNR1, CYP1B1, DRD3, EGFR, ESRRB, F3, HCAR2, HMGCR, HSPA1A, KDR, MET, MMP9, PIM1, PPARG, PRKCA, PRKCB, PRKCE, PTAFR, PTGS2, SLC1A1, SMAD3, SRC, TEK, TRPV1 5.13693
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX12, ALOX15, CSNK2A1, CYP19A1, CYP1A1, CYP3A4, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2 5.11906
[BP] GO:0040017 positive regulation of locomotion ALOX12, BCL2, EGFR, F3, IGF1R, INSR, KDR, MET, MMP9, PRKCA, PRKCE, PTAFR, PTGS2, SMAD3, SRC, TEK 5.10243
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, PPARG, PRKCD, PRKCE, PTGS2, SRC, TEK 5.05282
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, HSP90AB1, INSR, KDR, PIK3CA, PPARA, PPARG, SMAD3, SRC, TEK, TYR 5.04139
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PRKCB, PRKCE, PTGS2, SMAD3, SRC, TEK 5.0241
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CHRM3, CLK1, CSNK2A1, CYP1A1, CYP1A2, CYP3A4, DRD3, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, F3, FLT3, FUT7, GBA2, GLO1, HASPIN, HMGCR, HSP90AA1, HSPA1A, IGF1R, INSR, KDR, MAOA, MET, MMP1, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TYR, XDH 4.99862
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD3, EGFR, F3, INSR, MET, PIK3CA, PIK3CB, SRC, TEK, XDH 4.99862
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PTPN1, SRC, TEK 4.98453
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, EGFR, HSP90AA1, HSP90AB1, IGF1R, INSR, PRKCD, PRKCG, SRC, TNKS, TNKS2 4.96107
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, CYP3A4, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.9557
[BP] GO:0007154 None ADORA1, AXL, BCL2, CHRM1, CHRM2, CHRM3, CHRM5, CNR1, DRD3, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, PPARG, PRKCG, PTGS2, SLC1A1, TEK, TRPV1 4.93648
[BP] GO:0031399 regulation of protein modification process ADORA1, ALOX15, BCL2, CDC25B, DUSP3, DYRK1A, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SRC, TEK, XDH 4.9203
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PRKCB, PRKCE, PTGS2, SMAD3, SRC, TEK 4.9025
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, PPARG, RORC, SRC 4.87338
[BP] GO:0001775 cell activation ALOX5, AXL, BCL2, EGFR, FLT3, FUT7, HSP90AA1, HSP90AB1, HSPA1A, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, RORC, SMAD3, SRC, TRPV1 4.86725
[BP] GO:0009892 negative regulation of metabolic process ADORA1, APEX1, AURKB, BCL2, CNR1, CNR2, CSNK2A1, DRD3, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, HCAR2, HMGCR, HSP90AB1, HSPA1A, IGF1R, KDR, MET, MMP9, NR3C1, PIK3CA, PPARA, PPARG, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TNKS, TNKS2, TRPV1, XDH 4.86561
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CHRM1, CHRM3, CHRM5, CLK1, CYP1A1, EGFR, ESR1, FLT3, MET, PIK3CB, PIM1, PRKCD, SRC, TEK, TYR 4.82879
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, PIM1, PPARA, PPARG, RORC, SRC 4.80305
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DRD3, DUSP3, DYRK1A, DYRK3, ESR1, HMGCR, HSPA1A, IGF1R, MET, MMP9, PRKCD, PTGS2, PTPN1, SRC, XDH 4.80293
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ALOX15, APEX1, AURKB, BCL2, CA9, CDC25B, CDK6, CHRM5, CLK1, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD3, DUSP3, DYRK1A, DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, XDH 4.79795
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, BCL2, CDC25B, DUSP3, EGFR, ESRRB, FABP4, FLT3, GRM1, GRM5, HMGCR, HSP90AB1, IGF1R, INSR, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 4.79769
[BP] GO:0015844 None CHRM5, NISCH, SLC22A1, SLC22A2, SLC22A3 4.79147
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6 4.79147
[BP] GO:0044057 None ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, DRD3, EGFR, GPR35, GRM1, HCAR2, PRKCA, PTAFR, PTGS2, SLC1A1, SMAD3, TRPV1 4.78961
[BP] GO:0007196 None GRM1, GRM3, GRM5, GRM8 4.76488
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, CNR1, DRD3, EGFR, HCAR2, PIK3CB, PTGS2, TNKS, TNKS2 4.73956
[BP] GO:0030155 regulation of cell adhesion ALOX12, ALOX15, BCL2, CDK6, CYP1B1, DUSP3, KDR, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PTAFR, SMAD3, SRC, TEK 4.70399
[BP] GO:0002682 regulation of immune system process ADORA1, ALOX15, AXL, BCL2, CA2, CDK6, CNR1, CNR2, CYP19A1, DUSP3, ESR1, ESRRA, HCAR2, HSP90AA1, HSP90AB1, HSPA1A, MMP2, PIK3CA, PIK3CB, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PTAFR, PTPN1, SMAD3, SRC 4.67115
[BP] GO:0045913 None DYRK2, ESRRB, INSR, PPARA, PRKCE, PTAFR, SRC 4.66834
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, ALOX15, APEX1, AURKB, BCL2, CA9, CDC25B, CHRM5, CLK1, CNR1, CSNK2A1, CYP1A1, CYP1B1, DRD3, DUSP3, DYRK1A, DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, XDH 4.64915
[BP] GO:0043065 positive regulation of apoptotic process BCL2, CNR1, CYP1B1, F3, GRIK5, HCAR2, HMGCR, MMP9, PIK3CB, PPARG, PRKCD, PTGS2, SMAD3, SRC, TOP2A, TRPV1, XDH 4.60189
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, APEX1, EGFR, ESR1, FLT3, GRM5, IGF1R, INSR, MMP2, NR3C1, PPARG, PRKCD, PRKCE, PTAFR, PTGS2, SMAD3, SRC, TRPV1 4.58104
[BP] GO:0044093 positive regulation of molecular function ADORA1, AURKB, BCL2, CDC25B, EGFR, ESR1, ESR2, F3, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, HSPA1A, INSR, MET, MMP9, PIK3CA, PIK3CB, PPARG, PRKCB, PRKCD, PRKCE, PTAFR, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 4.56546
[BP] GO:2001225 regulation of chloride transport CA2, CA7, GRM5, PTAFR 4.56318
[BP] GO:0043068 positive regulation of programmed cell death BCL2, CNR1, CYP1B1, F3, GRIK5, HCAR2, HMGCR, MMP9, PIK3CB, PPARG, PRKCD, PTGS2, SMAD3, SRC, TOP2A, TRPV1, XDH 4.54918
[BP] GO:0007268 None CHRM1, CHRM2, CHRM3, CHRM5, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, PRKCG, SLC1A1 4.53195
[BP] GO:0098916 None CHRM1, CHRM2, CHRM3, CHRM5, DRD3, GRIA2, GRIK5, GRM1, GRM3, GRM5, PRKCG, SLC1A1 4.53195
[BP] GO:0032787 None ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, GLO1, PPARA, PPARG, PTGS1, PTGS2 4.5063
[BP] GO:0051338 regulation of transferase activity ADORA1, AURKB, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, HSP90AA1, HSP90AB1, IGF1R, INSR, PIK3CA, PIK3CB, PPARG, PRKCD, PTPN1, SRC, TEK, TNKS 4.49547
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, BCL2, CNR2, DRD3, DUSP3, DYRK1A, DYRK3, EGFR, ESR1, ESR2, GPR35, HMGCR, HSPA1A, IGF1R, MET, MMP9, PPARG, PRKCB, PRKCD, PTGS2, PTPN1, SMAD3, SRC, XDH 4.47915
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ALOX15, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, HSP90AB1, IGF1R, INSR, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 4.46022
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, BCL2, CNR2, DRD3, DUSP3, DYRK1A, DYRK3, EGFR, ESR1, ESR2, GPR35, HMGCR, HSPA1A, IGF1R, MET, MMP9, PPARG, PRKCB, PRKCD, PTGS2, PTPN1, SMAD3, SRC, XDH 4.4574
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, CYP3A4, ESR1, HSD17B1, HSD17B2 4.45634
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, APEX1, AXL, CYP1B1, EGFR, MMP9, PRKCD, SRC 4.45634
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CLK1, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD3, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HASPIN, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MAOA, MET, MMP1, MMP2, MMP9, NISCH, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, XDH 4.44866
[BP] GO:0003008 None ADORA1, AKR1B1, BCL2, CHRM1, CHRM3, CHRM5, CNR1, CNR2, CYP1B1, DRD3, EGFR, GRM1, GRM5, GRM8, HMGCR, HSD11B2, INSR, PIK3CA, PRKCG, PTAFR, PTGS2, SLC5A1, SRC, TEK, TRPV1, TYR 4.42821
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ALOX15, BCL2, CDC25B, DYRK1A, EGFR, FLT3, GRM1, GRM5, HMGCR, HSP90AB1, INSR, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 4.3904
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, HMGCR, MMP2, MMP9, PTAFR, PTGS2 4.37358
[BP] GO:0031347 regulation of defense response ADORA1, CNR1, CNR2, CYP19A1, EGFR, ESR1, FABP4, HSP90AB1, HSPA1A, MMP2, PPARA, PPARG, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK 4.37358
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F3, INSR, MET, PIK3CA, PIK3CB, SRC, TEK 4.36916
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ALOX15, DUSP3, EGFR, FLT3, GRM1, HMGCR, IGF1R, INSR, KDR, PIK3CB, PRKCA, PRKCD, PRKCE, PTPN1, SRC, TEK, XDH 4.30476
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, EGFR, FLT3, HSD11B2, NR3C1, PTAFR, PTGS2, SRC 4.30244
[BP] GO:0003018 None ADORA1, CHRM1, CHRM3, EGFR, HMGCR, PTAFR, PTGS2, SRC, TEK 4.30244
[BP] GO:0051972 regulation of telomerase activity AURKB, HSP90AA1, HSP90AB1, PPARG, SRC, TNKS 4.29528
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CNR2, CYP19A1, PPARA, PPARG, PRKCD, SMAD3, TEK 4.26492
[BP] GO:0080135 regulation of cellular response to stress CDK6, DUSP3, DYRK1A, DYRK3, EGFR, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, MET, NUAK1, PRKCD, PRKCG, PTGS2, PTPN1, XDH 4.247
[BP] GO:0015872 None CHRM5, SLC22A1, SLC22A2, SLC22A3 4.24172
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, AURKB, BCL2, CDC25B, EGFR, ESR1, F3, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, HSPA1A, INSR, PIK3CA, PIK3CB, PPARG, PRKCD, PRKCE, PTAFR, PTPN1, SMAD3, SRC, TEK, TNKS, XDH 4.24172
[BP] GO:0016572 histone phosphorylation AURKB, HASPIN, PRKCA, PRKCB, PRKCD 4.19346
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, EGFR, FLT3, GRM1, HMGCR, INSR, KDR, PIK3CB, PRKCA, PRKCE, PTPN1, SRC, TEK, XDH 4.19346
[BP] GO:1903426 None EGFR, HSP90AA1, HSP90AB1, INSR, PTGS2, SMAD3, TRPV1 4.16702
[BP] GO:0007346 regulation of mitotic cell cycle APEX1, AURKB, BCL2, CDC25B, CDK6, CYP1A1, DRD3, DUSP3, EGFR, HSP90AA1, HSPA1A, INSR, PIM1, PRKCA, SMAD3, TNKS, TOP2A 4.16516
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, ALOX15, APEX1, AURKB, BCL2, CA9, CDC25B, CHRM5, CLK1, CNR1, CSNK2A1, CYP1B1, DRD3, DUSP3, DYRK1A, DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, XDH 4.16125
[BP] GO:0009895 negative regulation of catabolic process ADORA1, BCL2, CNR1, EGFR, HCAR2, HSP90AB1, MET, PIK3CA, PPARA, PRKCG, SMAD3 4.15739
[BP] GO:0050994 None ADORA1, CNR1, HCAR2, PPARA, PRKCD, PRKCE 4.15621
[BP] GO:0010942 positive regulation of cell death BCL2, CNR1, CYP1B1, F3, GRIK5, HCAR2, HMGCR, MMP9, PIK3CB, PPARG, PRKCD, PTGS2, SMAD3, SRC, TOP2A, TRPV1, XDH 4.15331
[BP] GO:0015874 None NISCH, SLC22A1, SLC22A2 4.1262
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.1262
[BP] GO:0010675 None DYRK2, ESRRB, INSR, PPARA, PRKCE, PTAFR, RORC, SRC 4.11982
[BP] GO:0051052 regulation of DNA metabolic process AURKB, EGFR, HSP90AA1, HSP90AB1, IGF1R, INSR, PIK3CA, PPARG, PRKCD, PRKCG, SRC, TNKS, TNKS2 4.08851
[BP] GO:0050727 regulation of inflammatory response ADORA1, CNR1, CNR2, CYP19A1, EGFR, ESR1, FABP4, PPARA, PPARG, PRKCD, PTGS2, SMAD3, TEK 4.08851
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, PPARG, RORC, SRC 4.06209
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PTPN1, SMAD3, SRC, TEK 4.04978
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SRC, TEK 4.02011
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, EGFR, FLT3, HSD11B2, NR3C1, PTAFR, PTGS2, SRC 4.01237
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, EGFR, GRM5, IGF1R, INSR, MMP2, PPARG, PRKCD, PTAFR, PTGS2, SRC, TRPV1 4.00954
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, CYP3A4, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.99835
[BP] GO:0007216 None GRM1, GRM3, GRM5, GRM8 3.97236
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, EGFR, FLT3, GRM1, GRM5, HSP90AA1, HSP90AB1, INSR, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC, TEK, TNKS 3.963
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, APEX1, AXL, BCL2, CA2, CA9, CNR2, CYP1A1, CYP1A2, CYP1B1, DYRK2, EGFR, HSD11B2, HSP90AA1, HSP90AB1, HSPA1A, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PPARG, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TEK, TOP2A, TRPV1 3.95343
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, HMGCR, MMP2, MMP9, PPARG, PTAFR, PTGS2 3.9525
[BP] GO:0043434 None APEX1, FABP3, HSD11B2, INSR, PPARA, PPARG, PRKCD, PTGS2, SRC, TEK, TRPV1 3.95038
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, ALOX12, CNR2, CYP19A1, DRD3, HMGCR, PPARA, PPARG, PRKCD, SMAD3, TEK 3.93665
[BP] GO:0000302 response to reactive oxygen species AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, MMP9, PRKCD, SRC 3.93139
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, FLT3, GRM1, HMGCR, IGF1R, INSR, PIK3CB, PRKCD, PTPN1, SRC 3.91875
[BP] GO:0043279 None CNR1, DRD3, HSP90AB1, PPARG, PRKCE, PRKCG, TRPV1 3.89816
[BP] GO:0006979 response to oxidative stress AKR1B1, APEX1, AXL, BCL2, CYP1B1, EGFR, HSPA1A, MMP9, PRKCD, PTGS1, PTGS2, SRC 3.88198
[BP] GO:0010907 None DYRK2, ESRRB, INSR, PPARA, SRC 3.86605
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, ALPL, AXL, BCL2, CA2, CDK6, CHRM1, CHRM2, CHRM3, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, DYRK1A, DYRK1B, EGFR, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, HSP90AB1, INSR, KDR, MMP9, PIK3CA, PIM1, PPARA, PPARG, PTGS2, RORC, SMAD3, SRC, TEK, TYR 3.86364
[BP] GO:0031324 negative regulation of cellular metabolic process APEX1, AURKB, BCL2, CNR1, CSNK2A1, DRD3, DUSP3, DYRK1A, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, HMGCR, HSP90AB1, HSPA1A, IGF1R, MET, MMP9, NR3C1, PIK3CA, PPARA, PPARG, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TNKS, TNKS2, TRPV1, XDH 3.86248
[BP] GO:1901654 None AKR1B1, CA9, CSNK2A1, EGFR, NR3C1, PPARG, PRKCE, PTAFR, SRC 3.85961
[BP] GO:0009891 positive regulation of biosynthetic process AURKB, DRD3, DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MET, NR3C1, PPARA, PPARG, PRKCD, PTAFR, PTGS2, RORC, SMAD3, SRC, TNKS, TNKS2, TOP2A, TRPV1 3.82652
[BP] GO:0007267 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, CNR1, DRD3, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, PRKCG, SLC1A1, TEK 3.8255
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ALOX15, BCL2, CDC25B, CSNK2A1, DUSP3, DYRK1A, EGFR, ESR1, F3, FABP4, FLT3, GRM1, GRM5, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PPARG, PRKCA, PRKCD, PRKCE, PRKCG, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 3.75975
[BP] GO:0007213 None CHRM1, CHRM2, CHRM3, CHRM5 3.7475
[BP] GO:0019372 lipoxygenase pathway ALOX12, ALOX15, ALOX5, PTGS2 3.7475
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, AXL, BCL2, CA2, CHRM1, CYP19A1, DRD3, EGFR, HCAR2, HSP90AB1, INSR, PPARG, PRKCD, PRKCE, PTAFR, PTGS2, SMAD3, SRC, TRPV1 3.7475
[BP] GO:0035556 intracellular signal transduction AKR1B1, AXL, BCL2, CYP1B1, DRD3, DYRK2, EGFR, GRM5, HASPIN, IGF1R, INSR, KDR, MET, NISCH, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTPN1, SRC, TEK 3.72566
[BP] GO:0051384 response to glucocorticoid ALPL, BCL2, EGFR, FLT3, HSD11B2, NR3C1, PTAFR, PTGS2 3.7156
[BP] GO:0042752 None ADORA1, DRD3, PPARA, PPARG, PRKCG, RORC, TOP2A 3.70761
[BP] GO:0010810 regulation of cell-substrate adhesion ALOX15, BCL2, CDK6, KDR, PIK3CB, PRKCE, SMAD3, SRC, TEK 3.6847
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, HSP90AA1, HSP90AB1, SRC, TNKS, TNKS2 3.68003
[BP] GO:0006855 None SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2 3.68003
[BP] GO:0043271 negative regulation of ion transport ADORA1, BCL2, CNR1, DRD3, GPR35, MMP9, PRKCE, PTGS2 3.67594
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, EGFR, GRM5, IGF1R, INSR, MMP2, PPARG, PRKCD, PTAFR, PTGS2, SRC, TRPV1 3.67331
[BP] GO:0006940 None ADORA1, CHRM1, CHRM2, CHRM3, PTAFR, PTGS2 3.64552
[BP] GO:0046456 icosanoid biosynthetic process ALOX12, ALOX15, ALOX5, PTGS1, PTGS2 3.64501
[BP] GO:0009991 response to extracellular stimulus ALPL, AXL, BCL2, CNR1, CYP1A1, EGFR, HMGCR, HSD11B2, PPARG, PTGS2, SRC, TRPV1, TYR 3.63455
[BP] GO:0090087 None ACHE, ADORA1, CA2, CHRM1, CNR1, DRD3, DYRK2, EGFR, HCAR2, HMGCR, HSP90AB1, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC 3.63455
[BP] GO:0032845 None ADORA1, BCL2, HMGCR, PRKCE, SRC, TNKS, TNKS2, TRPV1 3.61803
[BP] GO:0051726 regulation of cell cycle APEX1, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, DRD3, DUSP3, EGFR, HSP90AA1, HSP90AB1, HSPA1A, INSR, PIM1, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TNKS, TOP2A 3.61803
[BP] GO:0007584 response to nutrient ALPL, CNR1, CYP1A1, EGFR, HMGCR, PPARG, PTGS2, TRPV1, TYR 3.60846
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, PRKCD, SRC 3.59218
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, AURKB, AXL, BCL2, CNR1, DRD3, ESR1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, PPARG, PRKCD, PRKCE, SMAD3, SRC, TEK, TNKS, TNKS2 3.59218
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, CDK6, KDR, PIK3CB, SMAD3, SRC, TEK 3.58525
[BP] GO:0045787 positive regulation of cell cycle APEX1, AURKB, CDC25B, CYP1A1, DRD3, DUSP3, EGFR, HSP90AB1, INSR, PRKCA, PRKCE, SRC 3.58085
[BP] GO:0038128 None EGFR, HSP90AA1, PIK3CA, PRKCA, SRC 3.54532
[BP] GO:0015893 None CA2, CHRM5, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2 3.54392
[BP] GO:2000278 regulation of DNA biosynthetic process AURKB, HSP90AA1, HSP90AB1, PPARG, SRC, TNKS, TNKS2 3.53842
[BP] GO:0031328 positive regulation of cellular biosynthetic process AURKB, DRD3, DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, FABP3, HSP90AA1, HSP90AB1, IGF1R, INSR, MET, NR3C1, PPARA, PPARG, PRKCD, PTAFR, PTGS2, RORC, SMAD3, SRC, TNKS, TNKS2, TOP2A, TRPV1 3.5229
[BP] GO:2001300 lipoxin metabolic process ALOX12, ALOX15, ALOX5 3.52047
[BP] GO:0008150 biological_process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CLK1, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD3, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HASPIN, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MAOA, MET, MMP1, MMP2, MMP9, NISCH, NQO2, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SLC5A1, SLC5A2, SLC5A4, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 3.51703
[BP] GO:0050801 ion homeostasis BCL2, CA12, CA2, CA7, DRD3, EGFR, ESR1, FABP3, GPR35, GRM1, GRM5, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 3.51278
[BP] GO:0006464 cellular protein modification process ALPL, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CHRM3, CLK1, CSNK2A1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, FLT3, FUT7, HASPIN, HSP90AA1, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 3.49661
[BP] GO:0036211 protein modification process ALPL, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CHRM3, CLK1, CSNK2A1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, FLT3, FUT7, HASPIN, HSP90AA1, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 3.49661
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, CA2, CHRM1, CHRM2, CHRM3, CHRM5, CNR1, CNR2, DRD3, ESR1, GPR35, GRM1, GRM3, GRM5, GRM8, HCAR2, INSR, PIK3CA, PIK3CB, PPARG, PTAFR, SRC 3.48484
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, PRKCD, SRC 3.47064
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, ALOX15, APEX1, AURKB, BCL2, CA9, CDC25B, CDK6, CHRM5, CLK1, CSNK2A1, CYP1A2, CYP1B1, DRD3, DUSP3, DYRK1A, DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP4, FLT3, GLO1, GRM1, GRM5, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, XDH 3.45856
[BP] GO:0051179 None ACHE, ADORA1, ALOX15, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM1, CHRM3, CHRM5, DRD3, EGFR, ESR1, FABP3, GRIA2, GRIA4, GRIK5, HASPIN, HSP90AA1, HSP90AB1, HSPA1A, MMP9, NISCH, PPARA, PPARG, PRKCB, PRKCD, PRKCE, PTAFR, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SLC5A1, SLC5A2, SLC5A4, SRC, TNKS, TNKS2, TRPV1, XDH 3.45084
[BP] GO:0045766 positive regulation of angiogenesis ALOX12, CYP1B1, F3, KDR, PRKCA, PRKCB, PTGS2, TEK 3.43469
[BP] GO:0003013 None ADORA1, CHRM1, CHRM3, EGFR, HMGCR, PTAFR, PTGS2, SRC, TEK 3.42704
[BP] GO:1903725 regulation of phospholipid metabolic process CHRM5, FABP3, FLT3, PRKCD, SRC, TEK 3.42704
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, HSP90AA1, KDR, PIK3CA, PIK3CB, SRC 3.42704
[BP] GO:0001101 response to acid chemical AKR1B1, EGFR, FABP3, HSD17B2, KDR, MMP2, PPARG, PRKCE, PTAFR, PTGS2, SRC 3.42301
[BP] GO:0045776 None ADORA1, CNR1, DRD3, PPARA, PTAFR 3.41017
[BP] GO:0043549 regulation of kinase activity ADORA1, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, HSP90AB1, IGF1R, INSR, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC, TEK 3.41017
[BP] GO:0043412 macromolecule modification ALPL, APEX1, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CHRM3, CLK1, CSNK2A1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, FLT3, FUT7, HASPIN, HSP90AA1, IGF1R, INSR, KDR, MET, NR3C1, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 3.38988
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, DRD3, KDR, PRKCE, SRC, TRPV1 3.38491
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, PRKCD, SRC, TEK 3.36378
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, EGFR, MMP2, MMP9, TEK 3.33308
[BP] GO:0010638 positive regulation of organelle organization ALOX15, AURKB, BCL2, DRD3, HSPA1A, INSR, KDR, MET, MMP9, PRKCE, SMAD3, SRC, TEK, TNKS, TNKS2 3.33215
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, ALOX15, APEX1, AURKB, BCL2, CA9, CDC25B, CLK1, CSNK2A1, CYP1B1, DRD3, DUSP3, DYRK1A, DYRK1B, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GRM1, GRM3, GRM5, GRM8, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, XDH 3.33022
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, PPARG, RORC 3.33022
[BP] GO:0009698 phenylpropanoid metabolic process CYP1A1, CYP2A13, CYP2A6 3.31474
[BP] GO:0035405 None HASPIN, PRKCA, PRKCB 3.31474
[BP] GO:0009804 coumarin metabolic process CYP1A1, CYP2A13, CYP2A6 3.31474
[BP] GO:0023052 None ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, CNR1, DRD3, ESR2, GRIA2, GRIK5, GRM1, GRM3, GRM5, PRKCG, SLC1A1, TEK 3.31474
[BP] GO:0042391 None ADORA1, BCL2, CNR1, CNR2, GPR35, GRIA2, GRIA4, GRIK5, GRM5, KDR, SRC, TRPV1 3.29982
[BP] GO:0050878 regulation of body fluid levels ADORA1, AKR1B1, ALOX12, CHRM1, CHRM3, F3, MET, PRKCA, PRKCD, PRKCE, SLC22A2, XDH 3.29982
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, ALOX12, ALOX15, CYP19A1, CYP3A4, HMGCR, PTAFR, TYR 3.29982
[BP] GO:0050890 None ADORA1, CHRM1, CNR1, DRD3, EGFR, GRM5, HMGCR, INSR, PRKCG, PTGS2 3.29388
[BP] GO:0010632 regulation of epithelial cell migration KDR, MET, MMP9, PPARG, PRKCA, PRKCE, PTGS2, SRC, TEK 3.28747
[BP] GO:0060078 None ADORA1, GRIA2, GRIA4, GRIK5, GRM5, TRPV1 3.28375
[BP] GO:0051172 None APEX1, AURKB, CSNK2A1, DRD3, DUSP3, DYRK1A, EGFR, ESR1, ESR2, ESRRA, FABP4, GRM3, GRM8, HMGCR, HSP90AB1, HSPA1A, IGF1R, MMP9, NR3C1, PPARA, PPARG, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RORC, SMAD3, SRC, TNKS, TNKS2, TRPV1, XDH 3.28336
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, EGFR, FLT3, GRM1, GRM5, HSP90AB1, INSR, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC, TEK 3.27083
[BP] GO:0045859 regulation of protein kinase activity ADORA1, CDC25B, DUSP3, EGFR, FABP4, FLT3, GRM1, GRM5, HMGCR, HSP90AB1, IGF1R, INSR, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC 3.25959
[BP] GO:0031667 response to nutrient levels ALPL, BCL2, CNR1, CYP1A1, EGFR, HMGCR, HSD11B2, PPARG, PTGS2, SRC, TRPV1, TYR 3.25489
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CLK1, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD3, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HASPIN, HCAR2, HMGCR, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MAOA, MET, MMP1, MMP2, MMP9, NISCH, NQO2, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC22A1, SLC22A2, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 3.237
[BP] GO:0006810 None ACHE, ADORA1, ALOX15, ALOX5, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM1, CHRM3, CHRM5, DRD3, FABP3, GRIA2, GRIA4, GRIK5, HSP90AA1, HSP90AB1, HSPA1A, MMP9, NISCH, PPARA, PPARG, PRKCB, PRKCD, PRKCE, PTAFR, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SLC5A1, SLC5A2, SLC5A4, SRC, TNKS, TRPV1, XDH 3.237
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR, PRKCD, PRKCE 3.21369
[BP] GO:0051098 regulation of binding AURKB, BCL2, HSP90AB1, MET, MMP9, PPARA, PPARG, PRKCD, SMAD3, SRC, TNKS 3.20252
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.2019
[BP] GO:0070542 None FABP3, PPARG, PRKCE, PTAFR, PTGS2, SRC 3.2019
[BP] GO:0051234 None ACHE, ADORA1, ALOX15, ALOX5, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM1, CHRM3, CHRM5, DRD3, EGFR, FABP3, GRIA2, GRIA4, GRIK5, HSP90AA1, HSP90AB1, HSPA1A, MMP9, NISCH, PPARA, PPARG, PRKCB, PRKCD, PRKCE, PTAFR, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SLC5A1, SLC5A2, SLC5A4, SRC, TNKS, TRPV1, XDH 3.18623
[BP] GO:0095500 None CHRM1, CHRM2, CHRM3, CHRM5 3.17911
[BP] GO:1903831 None CHRM1, CHRM2, CHRM3, CHRM5 3.17911
[BP] GO:1901655 None AKR1B1, EGFR, NR3C1, PPARG, PRKCE, SRC 3.17504
[BP] GO:0044267 cellular protein metabolic process ALPL, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CHRM3, CLK1, CSNK2A1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, FLT3, FUT7, HASPIN, HSP90AA1, IGF1R, INSR, KDR, MET, MMP1, MMP2, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 3.16306
[BP] GO:0031348 negative regulation of defense response ADORA1, CNR2, CYP19A1, PPARA, PPARG, PRKCD, SMAD3, TEK 3.15264
[BP] GO:0098771 inorganic ion homeostasis BCL2, CA12, CA2, CA7, DRD3, EGFR, ESR1, GPR35, GRM1, GRM5, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 3.14963
[BP] GO:0044070 regulation of anion transport ADORA1, CA2, CA7, GRM5, PRKCD, PTAFR 3.14963
[BP] GO:0033273 response to vitamin ALPL, CYP1A1, EGFR, PPARG, PTGS2, TYR 3.14963
[BP] GO:0072507 divalent inorganic cation homeostasis BCL2, DRD3, EGFR, ESR1, GPR35, GRM1, GRM5, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 3.13744
[BP] GO:0097746 None ADORA1, CHRM1, CHRM3, EGFR, HMGCR, PTAFR, PTGS2 3.13664
[BP] GO:0035296 None ADORA1, CHRM1, CHRM3, EGFR, HMGCR, PTAFR, PTGS2 3.13664
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR, HMGCR 3.11703
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.11588
[BP] GO:0006109 regulation of carbohydrate metabolic process DYRK2, ESRRB, INSR, PPARA, PRKCE, PTAFR, RORC, SRC 3.10941
[BP] GO:1904018 positive regulation of vasculature development ALOX12, CYP1B1, F3, KDR, PRKCA, PRKCB, PTGS2, TEK 3.09241
[BP] GO:0055082 cellular chemical homeostasis BCL2, CA2, CA7, DRD3, ESR1, GPR35, GRIK5, GRM1, GRM5, PIK3CA, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 3.07551
[BP] GO:0071396 cellular response to lipid AXL, CDK6, EGFR, ESR1, FLT3, NR3C1, PPARG, PRKCE, PTAFR, RORC, SRC 3.07551
[BP] GO:0009968 negative regulation of signal transduction BCL2, DRD3, DUSP3, DYRK1A, DYRK3, EGFR, ESR1, ESR2, HMGCR, HSPA1A, IGF1R, MET, MMP9, PPARG, PRKCB, PRKCD, PTGS2, PTPN1, SMAD3, SRC, XDH 3.07361
[BP] GO:0051128 regulation of cellular component organization ALOX12, ALOX15, AURKB, AXL, BCL2, CNR1, CSNK2A1, DRD3, EGFR, ESR1, ESR2, GRIK5, HSP90AA1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, PIK3CB, PPARG, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 3.06185
[BP] GO:0070201 None ACHE, BCL2, CHRM1, CNR1, DRD3, DYRK2, EGFR, HCAR2, HMGCR, HSP90AB1, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC 3.05107
[BP] GO:0071702 None ADORA1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM5, DRD3, FABP3, HSP90AA1, NISCH, PPARA, PPARG, PRKCB, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC5A1, SLC5A2, SLC5A4, TNKS, TRPV1 3.04964
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, DUSP3, EGFR, FLT3, GRM1, HMGCR, HSP90AB1, IGF1R, INSR, PIK3CB, PRKCD, PTPN1, SRC 3.03499
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, EGFR, PPARA, SMAD3 3.02965
[BP] GO:0007200 None CHRM1, CHRM2, CHRM3, CHRM5, ESR1, GRM5 3.02062
[BP] GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis HSP90AA1, HSP90AB1, PIK3CA, PIK3CB, PRKCD, PRKCE, SRC 3.02062
[BP] GO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis HSP90AA1, HSP90AB1, PIK3CA, PIK3CB, PRKCD, PRKCE, SRC 3.02062
[BP] GO:0051246 regulation of protein metabolic process ADORA1, ALOX15, BCL2, CDC25B, CSNK2A1, DUSP3, DYRK1A, EGFR, ESR1, F3, FABP4, FLT3, GRM1, GRM5, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PIK3CA, PIK3CB, PPARG, PRKCA, PRKCD, PRKCE, PRKCG, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 3.01486
[BP] GO:0060359 None CNR1, DRD3, HSP90AB1, PRKCE, PRKCG, PTAFR 2.99767
[BP] GO:0050880 None ADORA1, CHRM1, CHRM3, EGFR, HMGCR, PTAFR, PTGS2 2.98765
[BP] GO:0002431 Fc receptor mediated stimulatory signaling pathway HSP90AA1, HSP90AB1, PIK3CA, PIK3CB, PRKCD, PRKCE, SRC 2.98765
[BP] GO:0035150 None ADORA1, CHRM1, CHRM3, EGFR, HMGCR, PTAFR, PTGS2 2.96742
[BP] GO:0090066 None ADORA1, ALOX15, CHRM1, CHRM3, EGFR, HMGCR, HSP90AB1, PRKCD, PRKCE, PTAFR, PTGS2 2.95377
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, EGFR, FLT3, GRM1, GRM5, HSP90AB1, INSR, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC 2.95377
[BP] GO:0038094 Fc-gamma receptor signaling pathway HSP90AA1, HSP90AB1, PIK3CA, PIK3CB, PRKCD, PRKCE, SRC 2.94933
[BP] GO:0050776 regulation of immune response ALOX15, BCL2, CNR1, DUSP3, ESR1, HSP90AA1, HSP90AB1, HSPA1A, MMP2, PIK3CA, PIK3CB, PPARG, PRKCB, PRKCD, PRKCE, PTAFR, PTPN1, SMAD3, SRC 2.94044
[BP] GO:0032409 None BCL2, DRD3, GPR35, GRM5, MMP9, PPARG, PRKCD, PRKCE, PTAFR 2.94044
[BP] GO:0019538 protein metabolic process ACHE, ALPL, AURKB, AXL, BCL2, CDC25B, CDK6, CHRM1, CHRM3, CLK1, CSNK2A1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, F3, FLT3, FUT7, HASPIN, HSP90AA1, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A 2.93978
[BP] GO:0007271 None CHRM1, CHRM2, CHRM3, CHRM5 2.93756
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, BCL2, CDC25B, CYP19A1, EGFR, ESR1, ESRRB, HSD17B2, HSP90AB1, INSR, PPARG, PTGS2, SRC 2.89627
[BP] GO:0046320 None CNR1, FABP3, PPARA, PPARG 2.87467
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.86046
[BP] GO:0019752 carboxylic acid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, GLO1, PIM1, PPARA, PPARG, PTGS1, PTGS2, TYR 2.85269
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, DRD3, EGFR, HSPA1A, MAOA 2.84575
[BP] GO:0072347 None CNR1, DRD3, HSP90AB1, PRKCE, PRKCG 2.84575
[BP] GO:0046903 None ALOX5, AXL, CA2, CA9, CHRM1, CHRM3, CHRM5, DRD3, HSP90AA1, HSP90AB1, HSPA1A, MMP9, NISCH, PRKCD, PTAFR, SLC1A1, SLC22A2, TRPV1, XDH 2.8437
[BP] GO:0006874 cellular calcium ion homeostasis BCL2, DRD3, ESR1, GPR35, GRM1, GRM5, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 2.84197
[BP] GO:0043269 regulation of ion transport ADORA1, BCL2, CA2, CA7, CHRM1, CNR1, DRD3, GPR35, GRM5, MMP9, PRKCD, PRKCE, PTAFR, PTGS2 2.83496
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MMP9, PTGS2, PTPN1, SRC 2.83496
[BP] GO:0006636 unsaturated fatty acid biosynthetic process ALOX12, ALOX15, PTGS1, PTGS2 2.82282
[BP] GO:0010906 None DYRK2, ESRRB, INSR, PPARA, RORC, SRC 2.81199
[BP] GO:0045935 positive regulation of nucleobase-containing compound metabolic process AURKB, DRD3, DYRK1B, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, MET, NR3C1, PPARA, PPARG, PRKCD, PRKCG, PTPN1, RORC, SMAD3, SRC, TNKS, TNKS2, TOP2A 2.79923
[BP] GO:0051223 None ACHE, CHRM1, CNR1, DRD3, DYRK2, EGFR, HCAR2, HMGCR, HSP90AB1, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC 2.79174
[BP] GO:0061041 regulation of wound healing ALOX12, F3, HMGCR, PRKCA, PRKCD, PRKCE, SMAD3 2.79056
[BP] GO:0045785 positive regulation of cell adhesion ALOX12, ALOX15, CDK6, KDR, PIK3CA, PRKCA, PRKCE, PTAFR, SMAD3, SRC, TEK 2.79046
[BP] GO:0031329 regulation of cellular catabolic process APEX1, BCL2, CNR1, ESRRB, HSP90AB1, HSPA1A, INSR, KDR, MET, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCG, PTPN1 2.78882
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, HASPIN, TNKS, TNKS2 2.7866
[BP] GO:0045931 positive regulation of mitotic cell cycle APEX1, CDC25B, CYP1A1, DRD3, DUSP3, INSR, PRKCA 2.77581
[BP] GO:0019725 cellular homeostasis APEX1, BCL2, CA2, CA7, DRD3, ESR1, GPR35, GRIK5, GRM1, GRM5, PIK3CA, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 2.77263
[BP] GO:0007610 None BCL2, CNR1, DRD3, EGFR, GRM1, GRM5, HMGCR, INSR, PPARA, PRKCE, PRKCG, PTGS2, TRPV1 2.76489
[BP] GO:0019229 None CHRM1, CHRM3, EGFR, PTAFR, PTGS2 2.75742
[BP] GO:0022414 reproductive process AKR1B1, ALPL, AXL, BCL2, CDC25B, CNR1, CYP19A1, CYP1A1, EGFR, ESR1, ESRRB, HSD11B2, HSD17B2, HSP90AB1, INSR, MMP2, MMP9, PPARG, PTAFR, PTGS2, SRC, TOP2A 2.75556
[BP] GO:0035408 None PRKCA, PRKCB 2.75556
[BP] GO:0009115 None AOX1, XDH 2.75556
[BP] GO:2001301 lipoxin biosynthetic process ALOX12, ALOX15 2.75556
[BP] GO:2001302 lipoxin A4 metabolic process ALOX12, ALOX15 2.75556
[BP] GO:2001303 lipoxin A4 biosynthetic process ALOX12, ALOX15 2.75556
[BP] GO:0014074 response to purine-containing compound APEX1, PPARG, PTAFR, PTGS2, TEK, TRPV1, TYR 2.75556
[BP] GO:0055074 calcium ion homeostasis BCL2, DRD3, ESR1, GPR35, GRM1, GRM5, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 2.75151
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, PRKCD 2.73767
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 2.72136
[BP] GO:0055080 cation homeostasis BCL2, CA2, CA7, DRD3, EGFR, ESR1, GPR35, GRM1, GRM5, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 2.71614
[BP] GO:0072503 cellular divalent inorganic cation homeostasis BCL2, DRD3, ESR1, GPR35, GRM1, GRM5, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 2.70622
[BP] GO:0072593 reactive oxygen species metabolic process ALOX12, BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR 2.69582
[BP] GO:0050877 None ADORA1, CHRM1, CHRM5, CNR1, CNR2, CYP1B1, DRD3, EGFR, GRM1, GRM5, GRM8, HMGCR, INSR, PRKCG, PTGS2, TRPV1, TYR 2.68518
[BP] GO:0043278 None CNR1, DRD3, PRKCE, PRKCG 2.68518
[BP] GO:0014072 None CNR1, DRD3, PRKCE, PRKCG 2.68518
[BP] GO:0006352 DNA-templated transcription, initiation ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, PPARG, RORC 2.6819
[BP] GO:0043393 regulation of protein binding AURKB, BCL2, HSP90AB1, MET, MMP9, PPARA, PRKCD, SRC 2.6819
[BP] GO:1901342 regulation of vasculature development ALOX12, CYP1B1, F3, KDR, PPARG, PRKCA, PRKCB, PTGS2, TEK, XDH 2.68167
[BP] GO:0010564 regulation of cell cycle process APEX1, AURKB, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, DRD3, EGFR, HSP90AA1, HSP90AB1, HSPA1A, INSR, PRKCE, TNKS 2.67637
[BP] GO:0050793 regulation of developmental process ALOX12, AXL, BCL2, CA2, CDK6, CNR1, CYP1B1, DRD3, EGFR, ESR1, ESRRA, ESRRB, F3, HMGCR, HSP90AB1, INSR, KDR, NUAK1, PIK3CA, PIM1, PPARA, PPARG, PRKCA, PRKCB, PTGS2, RORC, SMAD3, SRC, TEK, TNKS2, TRPV1, XDH 2.67426
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, F3, MMP9, PPARG, PTGS2, SMAD3, SRC, XDH 2.67127
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, APEX1, AURKB, AXL, BCL2, CA1, CA2, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CLK1, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD3, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HASPIN, HCAR2, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NISCH, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, XDH 2.6702
[BP] GO:0042738 exogenous drug catabolic process CYP1A2, CYP2A6, CYP3A4 2.65718
[BP] GO:0015697 None SLC22A1, SLC22A2, SLC22A3 2.65718
[BP] GO:0045759 None CNR1, CNR2, GPR35 2.65718
[BP] GO:0010557 positive regulation of macromolecule biosynthetic process AURKB, DRD3, DYRK1B, DYRK2, EGFR, ESR1, ESR2, ESRRA, ESRRB, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MET, NR3C1, PPARA, PPARG, PTAFR, RORC, SMAD3, SRC, TNKS, TNKS2, TOP2A 2.65005
[BP] GO:1901653 cellular response to peptide AKR1B1, APEX1, GRM5, IGF1R, INSR, PPARG, PRKCD, SRC 2.64761
[BP] GO:0048608 reproductive structure development AXL, BCL2, CYP19A1, ESR1, HSD17B2, HSP90AB1, INSR, PPARG, SRC 2.63744
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, CYP3A4, FABP3, FABP4, GBA2 2.63744
[BP] GO:0022600 None CHRM1, CHRM3, CHRM5, DRD3, SLC5A1 2.62617
[BP] GO:0010811 positive regulation of cell-substrate adhesion ALOX15, CDK6, KDR, PRKCE, SMAD3, TEK 2.62161
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP3A4, EGFR 2.60043
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, DUSP3, EGFR, HMGCR, KDR, PRKCA, PTPN1, SRC, TEK 2.59241
[BP] GO:0030003 cellular cation homeostasis BCL2, CA2, CA7, DRD3, ESR1, GPR35, GRM1, GRM5, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 2.59114
[BP] GO:0009605 response to external stimulus ADORA1, ALPL, AXL, BCL2, CDK6, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, DRD3, EGFR, HMGCR, HSD11B2, PPARG, PRKCD, PTAFR, PTGS2, SMAD3, SRC, TRPV1, TYR 2.58698
[BP] GO:0032870 cellular response to hormone stimulus APEX1, EGFR, ESR1, FLT3, INSR, NR3C1, PPARG, PRKCD, PRKCE, SRC 2.57262
[BP] GO:1900076 regulation of cellular response to insulin stimulus ESRRA, PRKCB, PRKCD, PTPN1, SRC 2.57079
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 2.57079
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.56104
[BP] GO:0032230 positive regulation of synaptic transmission, GABAergic CA2, CA7, PRKCE 2.56104
[BP] GO:0032103 positive regulation of response to external stimulus CNR1, EGFR, F3, FABP4, KDR, MET, PRKCA, PTGS2, SMAD3 2.54031
[BP] GO:0051051 negative regulation of transport ADORA1, BCL2, CNR1, DRD3, DYRK2, GPR35, HMGCR, HSPA1A, MMP9, PRKCB, PRKCE, PTGS2 2.5309
[BP] GO:0042180 None AKR1B1, AKR1B10, CYP19A1, GLO1, HMGCR 2.51514
[BP] GO:0060079 None ADORA1, GRIA2, GRIA4, GRIK5, TRPV1 2.51514
[BP] GO:0051973 positive regulation of telomerase activity AURKB, HSP90AA1, HSP90AB1, TNKS 2.51026
[BP] GO:0006873 cellular ion homeostasis BCL2, CA2, CA7, DRD3, ESR1, GPR35, GRM1, GRM5, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 2.49563
[BP] GO:0045321 leukocyte activation ALOX5, AXL, BCL2, FLT3, FUT7, HSP90AA1, HSP90AB1, HSPA1A, MMP9, PRKCB, PRKCD, PRKCE, PTAFR, RORC, SMAD3, TRPV1 2.48329
[BP] GO:0032880 regulation of protein localization ACHE, BCL2, CHRM1, CNR1, CSNK2A1, DRD3, DYRK2, EGFR, HCAR2, HMGCR, HSP90AB1, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC 2.4777
[BP] GO:1903522 None ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, EGFR, PTAFR, PTGS2, SLC1A1 2.47611
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.4675
[BP] GO:0032467 None AURKB, CDC25B, DRD3, PRKCE 2.4675
[BP] GO:1900543 None DRD3, GRM3, GRM8, PPARA, PRKCA 2.46203
[BP] GO:0045980 None DRD3, GRM3, GRM8, PPARA, PRKCA 2.43454
[BP] GO:0015695 None SLC22A1, SLC22A2, SLC22A3, SLC47A1 2.42529
[BP] GO:1903034 regulation of response to wounding ALOX12, F3, HMGCR, PRKCA, PRKCD, PRKCE, SMAD3 2.41932
[BP] GO:0006954 inflammatory response ADORA1, ADORA3, ALOX15, AXL, CNR2, PIK3CA, PIK3CB, PTAFR, PTGS1, PTGS2, TRPV1 2.40685
[BP] GO:0043436 oxoacid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, GLO1, PIM1, PPARA, PPARG, PTGS1, PTGS2, TYR 2.40514
[BP] GO:0090257 None ADORA1, CHRM1, CHRM2, CHRM3, PRKCA, PTAFR, PTGS2, SMAD3 2.40054
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, ALOX12, MET, PIK3CA, TRPV1 2.39063
[BP] GO:0045725 None DYRK2, ESRRB, INSR 2.38335
[BP] GO:0044283 None AKR1B1, ALOX12, ALOX15, ALOX5, CYP19A1, CYP1A1, CYP3A4, HMGCR, PTAFR, PTGS1, PTGS2 2.37663
[BP] GO:0050730 None ADORA1, EGFR, FLT3, GRM5, PRKCD, PRKCE, PTPN1, SRC 2.36591
[BP] GO:0007568 aging APEX1, AURKB, BCL2, CNR1, CYP1A1, HMGCR, PRKCD, PTGS2 2.36591
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 2.3641
[BP] GO:0045765 regulation of angiogenesis ALOX12, CYP1B1, F3, KDR, PPARG, PRKCA, PRKCB, PTGS2, TEK 2.35579
[BP] GO:0099566 None GRM1, GRM5 2.35207
[BP] GO:0046110 None AOX1, XDH 2.35207
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.35207
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, CA2, CA7, EGFR, PRKCE, PTGS2 2.34882
[BP] GO:0031100 animal organ regeneration AXL, CSNK2A1, EGFR, FLT3, PPARG 2.34875
[BP] GO:0006082 organic acid metabolic process ALOX12, ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, FABP3, GBA2, GLO1, PIM1, PPARA, PPARG, PTGS1, PTGS2, TYR 2.33445
[BP] GO:0007611 None CNR1, DRD3, EGFR, GRM5, HMGCR, INSR, PRKCG, PTGS2 2.33191
[BP] GO:0051094 positive regulation of developmental process ALOX12, AXL, BCL2, CA2, CNR1, CYP1B1, ESRRB, F3, HMGCR, HSP90AB1, INSR, KDR, PIM1, PPARG, PRKCA, PRKCB, PTGS2, SMAD3, SRC, TEK 2.32586
[BP] GO:2000116 regulation of cysteine-type endopeptidase activity CSNK2A1, F3, MMP9, PPARG, PTGS2, SMAD3, SRC, XDH 2.32069
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.32017
[BP] GO:0032075 None HSPA1A, PRKCD, PTPN1 2.32017
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.32017
[BP] GO:0051131 None HSP90AA1, HSP90AB1, HSPA1A 2.32017
[BP] GO:0070875 None DYRK2, ESRRB, INSR 2.32017
[BP] GO:0018958 None AKR1B1, BCL2, DRD3, MAOA, TYR 2.30259
[BP] GO:0043086 negative regulation of catalytic activity CNR1, CNR2, CSNK2A1, DRD3, DUSP3, FABP4, GRM3, HMGCR, IGF1R, MMP9, PPARG, PRKCA, PRKCD, PTGS2, PTPN1, SRC 2.26773
[BP] GO:1901570 None ALOX12, ALOX15, ALOX5, PTGS1, PTGS2 2.25314
[BP] GO:0048732 gland development BCL2, CSNK2A1, CYP19A1, EGFR, INSR, PIK3CA, SMAD3, TYR 2.25314
[BP] GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress BCL2, CYP1B1, PRKCD 2.24394
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.24394
[BP] GO:0030258 lipid modification ALOX12, CYP1A1, CYP3A4, EGFR, MET, PIK3CA, PIK3CB, PPARG 2.24394
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, DRD3, EGFR, HCAR2, PRKCE, PTAFR, SRC, TRPV1 2.24394
[BP] GO:0043255 regulation of carbohydrate biosynthetic process DYRK2, ESRRB, INSR, PPARA, PTAFR 2.23233
[BP] GO:0030818 None DRD3, GRM3, GRM8, PRKCA 2.21485
[BP] GO:0050999 None CNR1, CNR2, EGFR, HSP90AA1 2.21485
[BP] GO:0032147 activation of protein kinase activity ADORA1, EGFR, GRM1, INSR, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC 2.20617
[BP] GO:0055065 metal ion homeostasis BCL2, DRD3, EGFR, ESR1, GPR35, GRM1, GRM5, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 2.20152
[BP] GO:1900182 positive regulation of protein localization to nucleus EGFR, HSP90AB1, PRKCD, PTGS2, SMAD3, SRC 2.19852
[BP] GO:0046683 response to organophosphorus APEX1, PTAFR, PTGS2, TEK, TRPV1, TYR 2.19852
[BP] GO:0038127 None EGFR, HSP90AA1, PIK3CA, PRKCA, SRC 2.18812
[BP] GO:0001954 positive regulation of cell-matrix adhesion CDK6, KDR, SMAD3, TEK 2.18082
[BP] GO:0072488 None SLC22A1, SLC22A2, SLC22A3 2.17729
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.17729
[BP] GO:0090330 regulation of platelet aggregation ALOX12, PRKCA, PRKCD 2.17729
[BP] GO:0019217 None CNR1, FABP3, PPARA, PPARG, PTGS2 2.1672
[BP] GO:0010038 response to metal ion ALOX15, BCL2, CA2, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 2.16216
[BP] GO:0050789 regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX12, ALOX15, APEX1, AURKB, AXL, BCL2, CA1, CA2, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CLK1, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD3, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HASPIN, HCAR2, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NISCH, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, XDH 2.15799
[BP] GO:0001936 None F3, KDR, PPARG, PRKCA, TEK, XDH 2.15095
[BP] GO:0030803 None DRD3, GRM3, GRM8, PRKCA 2.14909
[BP] GO:0010595 positive regulation of endothelial cell migration KDR, MET, PRKCA, PTGS2, TEK 2.14657
[BP] GO:0002684 positive regulation of immune system process AXL, BCL2, CA2, CNR1, HCAR2, HSP90AA1, HSP90AB1, HSPA1A, MMP2, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTAFR, SRC 2.13789
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.11308
[BP] GO:0001525 angiogenesis CYP1B1, KDR, MMP2, PIK3CA, PIK3CB, PRKCA, PTGS2, TEK 2.10877
[BP] GO:0051046 None ACHE, ADORA1, CNR1, CYP19A1, DRD3, EGFR, GRIK5, HCAR2, HMGCR, PRKCA, PRKCE, PTAFR, SRC, TRPV1 2.10606
[BP] GO:0031099 regeneration AXL, BCL2, CSNK2A1, EGFR, FLT3, PPARG 2.10606
[BP] GO:0071229 cellular response to acid chemical EGFR, KDR, MMP2, PPARG, PRKCE, PTAFR, SRC 2.09634
[BP] GO:1901374 None SLC22A1, SLC22A2 2.09634
[BP] GO:1905323 None HSP90AA1, HSP90AB1 2.09634
[BP] GO:0033031 positive regulation of neutrophil apoptotic process HCAR2, PIK3CB 2.09634
[BP] GO:0070213 None TNKS, TNKS2 2.09634
[BP] GO:0006145 None AOX1, XDH 2.09634
[BP] GO:0038171 None CNR1, CNR2 2.09634
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.09634
[BP] GO:0030815 None DRD3, GRM3, GRM8, PRKCA 2.09344
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP3A4, FABP3, FABP4, FUT7, GBA2, HSP90AA1, HSPA1A, MAOA, MMP1, MMP2, MMP9, PIK3CB, SRC, XDH 2.07904
[BP] GO:0050678 None CDK6, EGFR, F3, KDR, PPARG, PRKCA, SMAD3, TEK, XDH 2.07311
[BP] GO:0040008 regulation of growth ALOX12, BCL2, CSNK2A1, DRD3, EGFR, ESR2, HSPA1A, INSR, PIK3CA, PIM1, PPARG, SMAD3, TNKS2 2.06708
[BP] GO:0032868 None FABP3, HSD11B2, INSR, PPARA, PPARG, SRC 2.06708
[BP] GO:0002521 leukocyte differentiation AXL, BCL2, FLT3, FUT7, GLO1, MMP9, PPARG, RORC 2.06631
[BP] GO:0006875 cellular metal ion homeostasis BCL2, DRD3, ESR1, GPR35, GRM1, GRM5, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 2.06597
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, EGFR, HMGCR, KDR, PRKCA, SRC, TEK 2.06595
[BP] GO:1900372 None DRD3, GRM3, GRM8, PRKCA 2.06595
[BP] GO:0030809 None DRD3, GRM3, GRM8, PRKCA 2.06595
[BP] GO:0046626 regulation of insulin receptor signaling pathway PRKCB, PRKCD, PTPN1, SRC 2.06595
[BP] GO:0035306 None ADORA1, HSP90AB1, PRKCD, SMAD3 2.06595
[BP] GO:0035588 None ADORA1, ADORA3, PTAFR 2.0642
[BP] GO:0044089 positive regulation of cellular component biogenesis ALOX15, ESR1, HSPA1A, KDR, MET, MMP1, PRKCA, PRKCE, SMAD3, SRC, TEK 2.06299
[BP] GO:0046883 regulation of hormone secretion ADORA1, CNR1, CYP19A1, EGFR, HCAR2, HMGCR, PRKCA, PRKCE 2.05063
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, EGFR, FLT3, GRM1, INSR, PIK3CB, PTPN1, SRC 2.04019
[BP] GO:0030800 None DRD3, GRM3, GRM8, PRKCA 2.03656
[BP] GO:0030336 None ADORA1, ADORA3, APEX1, BCL2, CYP19A1, CYP1B1, NISCH, PPARG 2.03178
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.00705
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALOX12, ALOX15, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CNR1, CNR2, CSNK2A1, DRD3, EGFR, ESR1, F3, FLT3, GBA2, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HSP90AA1, IGF1R, INSR, KDR, MET, MMP2, NISCH, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTPN1, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SLC5A1, SLC5A2, SMAD3, SRC, TEK, TRPV1 9.09607
[CC] GO:0098590 plasma membrane region ADORA1, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CNR1, EGFR, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSP90AA1, HSP90AB1, INSR, MET, PRKCG, PTGS2, SLC1A1, SLC22A1, SRC, TEK, TRPV1 8.31372
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX12, ALOX15, ALOX5, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD3, EGFR, ESR1, F3, FLT3, FUT7, GBA2, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MAOA, MET, MMP2, NISCH, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS1, PTGS2, PTPN1, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SLC5A1, SLC5A2, SMAD3, SRC, TEK, TNKS, TNKS2, TRPV1, TYR 7.8069
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, AXL, CA4, CHRM1, CHRM2, CHRM3, CHRM5, CNR1, CNR2, DRD3, F3, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, PTAFR, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC5A1, SLC5A2, SLC5A4, TEK, TRPV1 7.68736
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ALOX15, AXL, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CNR1, CNR2, DRD3, DUSP3, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MET, PRKCG, PTAFR, PTGS2, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC5A1, SLC5A2, SLC5A4, SRC, TEK, TRPV1 7.42792
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, CNR1, CNR2, DRD3, FLT3, GPR35, GRIA2, GRM1, GRM3, GRM5, GRM8, IGF1R, INSR, KDR, MET, PTAFR, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC5A1, SLC5A2, SLC5A4, TEK, TRPV1 6.9588
[CC] GO:0097060 None CHRM1, CHRM2, CHRM3, CHRM5, CNR1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, PRKCG, TRPV1 6.22617
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ALOX15, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM1, CHRM2, CHRM3, CHRM5, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD3, DUSP3, EGFR, ESR1, F3, FLT3, FUT7, GBA2, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B2, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MAOA, MET, PIK3CA, PIK3CB, PRKCG, PTAFR, PTGS1, PTGS2, PTPN1, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SLC5A1, SLC5A2, SLC5A4, SRC, TEK, TRPV1, TYR 5.7263
[CC] GO:0044456 None ACHE, ADORA1, CHRM1, CHRM2, CHRM3, CHRM5, CNR1, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, PRKCG, SLC22A2, SRC, TRPV1 4.48808
[CC] GO:0042734 None CNR1, GRIK5, GRM1, GRM3, GRM5, GRM8 3.7475
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, CHRM3, EGFR, HSP90AB1, SLC22A1, TEK 3.71879
[CC] GO:0044464 cell part ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CLK1, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD3, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HASPIN, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MAOA, MET, MMP2, MMP9, NISCH, NQO2, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SLC5A1, SLC5A2, SLC5A4, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 3.54392
[CC] GO:0043227 membrane-bounded organelle ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CDK6, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD3, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GRIA4, GRIK5, GRM1, GRM5, HASPIN, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MAOA, MMP2, MMP9, NISCH, NQO2, NR3C1, NUAK1, PIK3CB, PIM1, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC22A2, SLC47A1, SLC5A1, SLC5A2, SMAD3, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 3.39867
[CC] GO:0045211 None CHRM1, CHRM2, CHRM3, CHRM5, GRIA2, GRIA4, GRIK5, GRM3, TRPV1 3.33705
[CC] GO:0043226 organelle ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA6, CA9, CDK6, CHRM1, CLK1, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, DRD3, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GRIA4, GRIK5, GRM1, GRM3, GRM5, HASPIN, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MAOA, MMP2, MMP9, NISCH, NQO2, NR3C1, NUAK1, PIK3CB, PIM1, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC22A2, SLC47A1, SLC5A1, SLC5A2, SMAD3, SRC, TNKS, TNKS2, TOP2A, TYR, XDH 3.13546
[CC] GO:0014069 None ADORA1, CHRM1, GRIK5, GRM1, GRM3, GRM5, PRKCG, SRC 2.76489
[CC] GO:0099572 None ADORA1, CHRM1, GRIK5, GRM1, GRM3, GRM5, PRKCG, SRC 2.76489
[CC] GO:0043005 None ADORA1, CA2, CHRM1, CHRM2, CHRM3, CNR1, CNR2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PRKCG, PTGS2, SRC 2.74464
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, APEX1, AURKB, BCL2, CA1, CA2, CA4, CA5A, CA5B, CA7, CDC25B, CDK6, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD3, DUSP3, DYRK2, DYRK3, EGFR, ESR1, ESR2, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GRIA2, GRIA4, GRIK5, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, INSR, KDR, MAOA, MMP2, MMP9, NISCH, NQO2, NR3C1, PIK3CA, PIK3CB, PIM1, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS1, PTGS2, PTPN1, SMAD3, SRC, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 2.64552
[CC] GO:0048471 perinuclear region of cytoplasm ACHE, AKR1B1, APEX1, CA4, EGFR, HSPA1A, PPARG, PRKCA, PRKCD, PRKCE, PRKCG, SRC, TNKS2, TYR 2.60642
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, EGFR, GBA2, GRIA2, HMGCR, HSD11B1, HSD11B2, HSD17B2, PTGS1, PTGS2 2.559
[CC] GO:0005783 None ADORA1, APEX1, BCL2, CA4, CYP19A1, FLT3, GBA2, GRIK5, HMGCR, HSPA1A, KDR, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, XDH 2.43855
[CC] GO:0044463 None ADORA1, AKR1B1, CA4, CA9, CHRM1, CHRM2, CHRM3, CNR1, GRIA2, GRIA4, GRIK5, GRM3, HSP90AA1, HSP90AB1, INSR, PTGS1, SRC, TRPV1 2.35207
[CC] GO:0120038 None ADORA1, AKR1B1, CA4, CA9, CHRM1, CHRM2, CHRM3, CNR1, GRIA2, GRIA4, GRIK5, GRM3, HSP90AA1, HSP90AB1, INSR, PTGS1, SRC, TRPV1 2.35207
[CC] GO:0042995 cell projection ADORA1, AKR1B1, CA2, CDK6, CHRM1, CHRM2, CHRM3, CNR1, CNR2, DRD3, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PIK3CA, PRKCG, PTGS2, SRC, TEK 2.25038
[CC] GO:0120025 None ADORA1, AKR1B1, CA2, CDK6, CHRM1, CHRM2, CHRM3, CNR1, CNR2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, PIK3CA, PRKCG, PTGS2, SRC, TEK 2.1447
[CC] GO:0043235 receptor complex EGFR, GRIA2, GRIA4, GRIK5, GRM1, HSP90AB1, IGF1R, INSR, SMAD3 2.13687
[CC] GO:0097458 None ADORA1, CA2, CHRM1, CHRM2, CHRM3, CNR1, CNR2, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, INSR, PRKCG, PTGS1, PTGS2, SLC22A2, SRC, TRPV1 2.03924
[MF] GO:0046914 transition metal ion binding ALOX12, ALOX15, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DYRK2, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP2, MMP9, NQO2, NR3C1, PIM1, PPARA, PPARG, PRKCA, PRKCB, PRKCG, PTPN1, RORC, SMAD3, TNKS, TYR, XDH 18.6151
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 15.054
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CDK6, CHRM1, CHRM2, CHRM3, CLK1, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4, DRD3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 14.7412
[MF] GO:0043167 ion binding ACHE, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDK6, CHRM3, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, GLO1, HASPIN, HMGCR, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NISCH, NQO2, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 14.7412
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM3, CHRM5, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, F3, FLT3, FUT7, GBA2, GLO1, HASPIN, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSP90AA1, HSPA1A, IGF1R, INSR, KDR, MAOA, MET, MMP1, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, SRC, TEK, TNKS, TNKS2, TOP2A, TYR, XDH 13.2335
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSP90AA1, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK 11.0396
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, CNR1, CNR2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, NR3C1, PPARA, PPARG, PTAFR, RORC, TEK, TRPV1 10.6537
[MF] GO:0004713 protein tyrosine kinase activity AXL, CLK1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HSP90AA1, IGF1R, INSR, KDR, MET, PRKCD, SRC, TEK 10.3695
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSP90AA1, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK 10.1825
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP2, MMP9, NQO2, NR3C1, PPARA, PPARG, PRKCA, PRKCB, PRKCG, PTPN1, RORC, SMAD3, TNKS 9.90494
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AXL, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CNR1, CNR2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, NR3C1, PPARA, PPARG, PTAFR, RORC, TEK, TRPV1 9.54539
[MF] GO:0016301 kinase activity AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSP90AA1, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK 9.44226
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, CNR1, CNR2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, NR3C1, PPARA, PPARG, PRKCE, PTAFR, RORC, SMAD3, TEK, TRPV1 9.44226
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, CNR1, CNR2, DRD3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, NR3C1, PPARA, PPARG, PTAFR, RORC, TEK, TRPV1 9.38754
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 9.11655
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 9.09183
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, AOX1, APEX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MAOA, NQO2, PTGS1, PTGS2, TYR, XDH 8.77639
[MF] GO:0043169 cation binding ACHE, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CHRM3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD3, DYRK2, DYRK3, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP2, MMP9, NQO2, NR3C1, NUAK1, PIM1, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SMAD3, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 8.02618
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSP90AA1, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK 8.02215
[MF] GO:0036094 small molecule binding ADORA1, AOX1, AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FABP3, FABP4, FLT3, HASPIN, HMGCR, HSD11B2, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SLC1A1, SRC, TEK, TOP2A, TRPV1, XDH 7.57054
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, CNR1, CNR2, DRD3, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, PPARG, PTAFR, TEK, TRPV1 7.42792
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, CHRM1, CHRM2, CHRM3, CHRM5, CNR1, CNR2, DRD3, EGFR, F3, FLT3, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HCAR2, IGF1R, INSR, KDR, MET, PPARG, PTAFR, TEK, TRPV1 7.42792
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4 7.32338
[MF] GO:0008066 None GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8 7.20001
[MF] GO:0043168 anion binding ALOX15, AOX1, AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, F3, FABP3, FABP4, FLT3, HASPIN, HMGCR, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NISCH, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, SLC1A1, SRC, TEK, TOP2A, TRPV1, XDH 7.16341
[MF] GO:0005524 ATP binding AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 7.06859
[MF] GO:0005506 iron ion binding ALOX12, ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, XDH 7.05612
[MF] GO:0046872 metal ion binding ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DYRK2, DYRK3, ESR1, ESR2, ESRRA, ESRRB, GLO1, MMP1, MMP2, MMP9, NQO2, NR3C1, NUAK1, PIM1, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SMAD3, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 7.0148
[MF] GO:0004674 protein serine/threonine kinase activity AURKB, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, HASPIN, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG 6.97045
[MF] GO:0032559 adenyl ribonucleotide binding AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 6.86269
[MF] GO:0030554 adenyl nucleotide binding AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 6.79892
[MF] GO:0000166 nucleotide binding AOX1, AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HMGCR, HSD11B2, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1, XDH 6.73629
[MF] GO:1901265 nucleoside phosphate binding AOX1, AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HMGCR, HSD11B2, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1, XDH 6.73399
[MF] GO:0030594 None CHRM1, CHRM2, CHRM3, CHRM5, DRD3, GRIA2, GRIA4, GRIK5, GRM1, GRM5 6.52933
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, GLO1 6.47463
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, NR3C1, PPARA, PPARG, RORC 6.267
[MF] GO:0005496 steroid binding CYP3A4, ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, NR3C1, RORC 6.2423
[MF] GO:0043560 insulin receptor substrate binding IGF1R, INSR, PIK3CA, PIK3CB, PRKCD 6.19032
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 6.10927
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 6.10563
[MF] GO:0016907 None CHRM1, CHRM2, CHRM3, CHRM5 5.96764
[MF] GO:0004712 protein serine/threonine/tyrosine kinase activity AURKB, CLK1, DYRK1A, DYRK1B, DYRK2, DYRK3, PRKCG 5.96764
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, PTGS1, PTGS2, SRC 5.92953
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, PTGS1, PTGS2, SRC 5.64377
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, PPARG, RORC 5.53387
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, PPARG, RORC 5.53387
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 5.37485
[MF] GO:0004697 None PRKCA, PRKCB, PRKCD, PRKCE, PRKCG 5.35138
[MF] GO:0008289 lipid binding ALOX15, AXL, CYP3A4, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, HSD11B2, HSD17B1, NISCH, NR3C1, PPARA, PPARG, PTAFR, RORC, TRPV1 5.26166
[MF] GO:0030235 nitric-oxide synthase regulator activity EGFR, ESR1, HSP90AA1, HSP90AB1 5.23405
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, PTGS1, PTGS2, TYR 5.2338
[MF] GO:0035639 purine ribonucleoside triphosphate binding AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 5.20907
[MF] GO:0042562 hormone binding ACHE, CHRM3, EGFR, HSD17B1, IGF1R, INSR, NQO2, NR3C1 5.16274
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, HMGCR, HSD11B2, HSD17B1, NQO2, PTGS1, PTGS2, SRC, XDH 5.15533
[MF] GO:0032555 purine ribonucleotide binding AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 4.99862
[MF] GO:0017076 purine nucleotide binding AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 4.94524
[MF] GO:0032553 ribonucleotide binding AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP2A, TRPV1 4.93313
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, TYR 4.82956
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 4.73155
[MF] GO:0097367 carbohydrate derivative binding ADORA1, AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, HASPIN, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, SRC, TEK, TOP2A, TRPV1 4.52269
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP3A4 4.49282
[MF] GO:0019899 enzyme binding AURKB, BCL2, CDC25B, CYP1A1, CYP1A2, CYP2A6, CYP3A4, DUSP3, EGFR, ESR1, ESR2, ESRRB, F3, GRM5, HMGCR, HSP90AA1, HSP90AB1, HSPA1A, MET, NR3C1, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PTAFR, PTGS2, PTPN1, SMAD3, SRC, TEK, TNKS2, TOP2A 4.45656
[MF] GO:0004698 None PRKCA, PRKCB, PRKCG 4.1262
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2A13, CYP2A6, CYP3A4 3.80762
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CDC25B, CDK6, CLK1, CSNK2A1, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, F3, FLT3, HASPIN, HSP90AA1, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SRC, TEK 3.7475
[MF] GO:0042802 identical protein binding ACHE, AOX1, BCL2, CSNK2A1, DYRK1A, EGFR, ESR1, ESR2, FLT3, GRIK5, HMGCR, HSP90AA1, HSP90AB1, IGF1R, KDR, MET, MMP9, NISCH, NQO2, PPARG, PTGS2, SLC22A1, SMAD3, TOP2A, TRPV1, TYR, XDH 3.7296
[MF] GO:0035173 histone kinase activity AURKB, HASPIN, PRKCA, PRKCB 3.64864
[MF] GO:0019901 None CDC25B, DUSP3, EGFR, ESR1, GRM5, HSP90AA1, HSP90AB1, NR3C1, PRKCB, PRKCD, PTAFR, PTPN1, SMAD3, SRC, TOP2A 3.61803
[MF] GO:0019900 None AURKB, CDC25B, DUSP3, EGFR, ESR1, GRM5, HSP90AA1, HSP90AB1, NR3C1, PRKCB, PRKCD, PTAFR, PTPN1, SMAD3, SRC, TOP2A 3.58085
[MF] GO:0015464 None CHRM1, CHRM2, CHRM3, CHRM5 3.55977
[MF] GO:0005329 None SLC22A1, SLC22A2, SLC22A3 3.52047
[MF] GO:0005412 None SLC5A1, SLC5A2, SLC5A4 3.52047
[MF] GO:0003674 molecular_function ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX12, ALOX15, ALOX5, ALPL, AOX1, APEX1, AURKB, AXL, BCL2, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CDK6, CHRM1, CHRM2, CHRM3, CHRM5, CLK1, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD3, DUSP3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, GLO1, GPR35, GRIA2, GRIA4, GRIK5, GRM1, GRM3, GRM5, GRM8, HASPIN, HCAR2, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MAOA, MET, MMP1, MMP2, MMP9, NISCH, NQO2, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTAFR, PTGS1, PTGS2, PTPN1, RORC, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SLC5A1, SLC5A2, SLC5A4, SMAD3, SRC, TEK, TNKS, TNKS2, TOP2A, TRPV1, TYR, XDH 3.51181
[MF] GO:0035184 None HASPIN, PRKCA, PRKCB 3.31474
[MF] GO:0019902 phosphatase binding BCL2, EGFR, HMGCR, MET, PPARA, PPARG, PTPN1, SMAD3 3.26754
[MF] GO:0032403 protein complex binding ACHE, ADORA1, APEX1, EGFR, ESRRB, FLT3, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MMP9, NISCH, PPARA, PTPN1, SMAD3, SRC 3.23644
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, HMGCR, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.23644
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, APEX1, CSNK2A1, EGFR, ESRRB, FLT3, HSP90AA1, HSP90AB1, IGF1R, INSR, KDR, MMP9, NISCH, PIM1, PPARA, PTPN1, SMAD3, SRC 3.13107
[MF] GO:0035258 None ESR1, FLT3, PPARG, PRKCB, SMAD3, SRC 2.99767
[MF] GO:0008504 None SLC22A1, SLC22A2, SLC22A3 2.99767
[MF] GO:0016725 oxidoreductase activity, acting on CH or CH2 groups CYP1A2, CYP3A4, XDH 2.99767
[MF] GO:0015651 None SLC22A1, SLC22A2, SLC22A3 2.99767
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 2.99767
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX12, ALOX15, ALOX5, PTGS2 2.99329
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 2.93756
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX12, ALOX15, ALOX5, PTGS2 2.93756
[MF] GO:0015238 None SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2 2.85439
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 2.82282
[MF] GO:0097159 organic cyclic compound binding ADORA1, AOX1, APEX1, AURKB, AXL, BCL2, CDK6, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DRD3, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HASPIN, HMGCR, HSD11B2, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 2.8046
[MF] GO:0004930 None ADORA1, ADORA3, CHRM1, CHRM2, CHRM3, CHRM5, CNR1, CNR2, DRD3, GPR35, GRM1, GRM3, GRM5, GRM8, HCAR2, PPARG, PTAFR 2.79046
[MF] GO:0004629 None ADORA1, CHRM1, CHRM3, CHRM5 2.77303
[MF] GO:0009931 None PRKCA, PRKCB, PRKCG 2.75556
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.75556
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.75556
[MF] GO:0047977 hepoxilin-epoxide hydrolase activity ALOX12, ALOX15 2.75556
[MF] GO:0003845 None HSD11B1, HSD11B2 2.75556
[MF] GO:0008389 None CYP2A13, CYP2A6 2.75556
[MF] GO:0035403 None PRKCA, PRKCB 2.75556
[MF] GO:1901363 heterocyclic compound binding ADORA1, AOX1, APEX1, AURKB, AXL, BCL2, CDK6, CLK1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP3A4, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, ESR1, ESR2, ESRRA, ESRRB, FLT3, HASPIN, HMGCR, HSD11B2, HSD17B1, HSP90AA1, HSP90AB1, HSPA1A, IGF1R, INSR, KDR, MET, NQO2, NR3C1, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PPARG, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 2.68049
[MF] GO:0010857 None PRKCA, PRKCB, PRKCG 2.65718
[MF] GO:0031072 heat shock protein binding ADORA1, CSNK2A1, HSP90AB1, HSPA1A, KDR, NR3C1 2.64134
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 2.58115
[MF] GO:0099528 None CHRM1, CHRM2, CHRM3, CHRM5 2.42529
[MF] GO:0016740 transferase activity AURKB, AXL, CDK6, CLK1, CSNK2A1, DYRK1A, DYRK1B, DYRK2, DYRK3, EGFR, FLT3, FUT7, HASPIN, HSP90AA1, IGF1R, INSR, KDR, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TNKS, TNKS2 2.40685
[MF] GO:0019903 protein phosphatase binding BCL2, EGFR, HMGCR, MET, PPARG, PTPN1 2.39063
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.35207
[MF] GO:0015307 None SLC47A1, SLC47A2 2.35207
[MF] GO:1901375 None SLC22A1, SLC22A2 2.35207
[MF] GO:0070576 vitamin D 24-hydroxylase activity CYP1A1, CYP3A4 2.35207
[MF] GO:0004949 None CNR1, CNR2 2.35207
[MF] GO:0004052 arachidonate 12-lipoxygenase activity ALOX12, ALOX15 2.35207
[MF] GO:0005333 None SLC22A1, SLC22A2 2.35207
[MF] GO:0051120 hepoxilin A3 synthase activity ALOX12, ALOX15 2.35207
[MF] GO:0005277 None SLC22A1, SLC22A2 2.35207
[MF] GO:0099583 None GRM1, GRM5 2.35207
[MF] GO:0008513 None SLC22A1, SLC22A2 2.35207
[MF] GO:0004699 None PRKCD, PRKCE 2.35207
[MF] GO:0015291 None SLC1A1, SLC22A1, SLC22A2, SLC47A1, SLC47A2, SLC5A1, SLC5A2, SLC5A4 2.25314
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.21485
[MF] GO:0004970 None GRIA2, GRIA4, GRIK5 2.11308
[MF] GO:0005234 None GRIA2, GRIA4, GRIK5 2.11308
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.09634
[MF] GO:0034875 caffeine oxidase activity CYP1A2, CYP3A4 2.09634
[MF] GO:0004971 None GRIA2, GRIA4 2.09634
[MF] GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor CYP1A2, CYP3A4 2.09634
[MF] GO:0005231 None GRIA2, GRIA4, GRIK5, TRPV1 2.09344
[MF] GO:0051213 dioxygenase activity ALOX12, ALOX15, ALOX5, PTGS1, PTGS2 2.05562
[MF] GO:0008081 None ADORA1, APEX1, CHRM1, CHRM3, CHRM5 2.03656
[MF] GO:0008324 None GRIA2, GRIA4, GRIK5, SLC1A1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SLC5A1, SLC5A2, SLC5A4, TRPV1 2.02796
[MF] GO:0005355 None SLC5A1, SLC5A2, SLC5A4 2.00705
[MF] GO:0004715 non-membrane spanning protein tyrosine kinase activity CLK1, DYRK1A, PRKCD, SRC 2.00705


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, GRIA2, CHRM3, CHRM1, GPR35, GRIK5, CHRM5, PTAFR, TRPV1, NR3C1, GRM1, GRM3, GRM5, CNR2, CNR1, ADORA3, GRM8, ADORA1, DRD3, GRIA4 13.4153
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 15.7582
Estrogen signaling pathway_Homo sapiens_hsa04915 HSP90AA1, HSP90AB1, SRC, MMP2, PRKCD, PIK3CB, MMP9, ESR1, GRM1, EGFR, ESR2, PIK3CA, HSPA1A 11.6735
Pathways in cancer_Homo sapiens_hsa05200 PRKCG, HSP90AA1, SMAD3, HSP90AB1, PRKCB, FLT3, MMP1, MMP2, PRKCA, PIK3CB, PTGS2, MMP9, EGFR, IGF1R, CDK6, PIK3CA, BCL2, PPARG, MET 9.7496
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, PIK3CA, PRKCB, MMP2, PRKCE, PRKCD, BCL2, PIM1, PRKCA, PIK3CB, F3 9.0595
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 9.1746
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, PRKCG, ACHE, CHRM3, CHRM1, PIK3CA, PRKCB, CHRM5, BCL2, PRKCA, PIK3CB 8.7328
Glutamatergic synapse_Homo sapiens_hsa04724 GRM3, PRKCG, GRIA2, GRM5, PRKCB, GRIK5, GRM8, SLC1A1, PRKCA, GRM1, GRIA4 8.6572
Proteoglycans in cancer_Homo sapiens_hsa05205 PRKCG, PRKCB, SRC, MMP2, PRKCA, PIK3CB, MMP9, ESR1, EGFR, IGF1R, PIK3CA, KDR, MET 8.1849
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PRKCG, PIK3CA, PRKCB, SRC, PRKCE, PRKCD, PRKCA, ALOX12, PIK3CB, TRPV1 8.1218
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP3A4, CYP19A1 8.7328
Rap1 signaling pathway_Homo sapiens_hsa04015 PRKCG, PRKCB, SRC, INSR, PRKCA, PIK3CB, EGFR, IGF1R, PIK3CA, CNR1, KDR, TEK, MET 8.0569
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, HSP90AA1, HSP90AB1, CHRM1, INSR, PRKCA, PIK3CB, EGFR, IGF1R, CDK6, PIK3CA, KDR, BCL2, TEK, MET 7.451
HIF-1 signaling pathway_Homo sapiens_hsa04066 PRKCG, PIK3CA, PRKCB, INSR, BCL2, PRKCA, TEK, PIK3CB, EGFR, IGF1R 7.9788
MicroRNAs in cancer_Homo sapiens_hsa05206 PRKCG, PRKCB, PRKCE, PRKCA, PTGS2, MMP9, EGFR, CDC25B, CDK6, PIK3CA, BCL2, PIM1, CYP1B1, MET 7.3721
VEGF signaling pathway_Homo sapiens_hsa04370 PRKCG, PIK3CA, PRKCB, SRC, KDR, PRKCA, PIK3CB, PTGS2 7.3868
Glioma_Homo sapiens_hsa05214 PRKCG, CDK6, PIK3CA, PRKCB, PRKCA, PIK3CB, EGFR, IGF1R 7.2177
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, PRKCG, CHRM3, GRM5, CHRM1, PRKCB, CHRM5, PTAFR, PRKCA, GRM1, EGFR 6.9087
Choline metabolism in cancer_Homo sapiens_hsa05231 PRKCG, SLC22A3, PIK3CA, PRKCB, SLC22A2, SLC22A1, PRKCA, PIK3CB, EGFR 6.9686
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PRKCG, GRIA2, GRM5, PRKCB, CNR1, PRKCA, PTGS2, GRM1, GRIA4 6.9686
Hepatitis B_Homo sapiens_hsa05161 PRKCG, CDK6, SMAD3, PIK3CA, PRKCB, SRC, BCL2, PRKCA, PIK3CB, MMP9 6.7479
Focal adhesion_Homo sapiens_hsa04510 PRKCG, PIK3CA, PRKCB, SRC, KDR, BCL2, PRKCA, PIK3CB, MET, EGFR, IGF1R 6.4887
Serotonergic synapse_Homo sapiens_hsa04726 PRKCG, PRKCB, MAOA, ALOX5, ALOX15, PRKCA, ALOX12, PTGS2, PTGS1 6.6521
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PRKCG, HSD11B2, PIK3CA, PRKCB, INSR, PRKCA, PIK3CB 7.3868
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 6.8496
Ras signaling pathway_Homo sapiens_hsa04014 PRKCG, PIK3CA, PRKCB, INSR, KDR, PRKCA, TEK, PIK3CB, MET, EGFR, IGF1R 6.0311
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PRKCG, PIK3CA, PRKCB, ADORA3, PRKCE, BCL2, ADORA1, PRKCA, PIK3CB 6.4725
Phospholipase D signaling pathway_Homo sapiens_hsa04072 GRM3, GRM5, PIK3CA, INSR, GRM8, PRKCA, PIK3CB, GRM1, EGFR 5.8193
Non-small cell lung cancer_Homo sapiens_hsa05223 PRKCG, CDK6, PIK3CA, PRKCB, PRKCA, PIK3CB, EGFR 6.4887
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, PTGS2, CYP3A4 6.549
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, PRKCB, INSR, PRKCE, PRKCD, PIK3CB, PPARA 5.7014
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, INSR, ADORA1, PIK3CB, PTGS2, PTGS1 6.4887
Metabolic pathways_Homo sapiens_hsa01100 MAOA, ALOX15, AKR1B1, ALOX12, HMGCR, PTGS2, TYR, CYP3A4, GBA2, CYP19A1, PTGS1, HSD11B1, CYP2A6, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 5.118
ErbB signaling pathway_Homo sapiens_hsa04012 PRKCG, PIK3CA, PRKCB, SRC, PRKCA, PIK3CB, EGFR 5.2394
Prostate cancer_Homo sapiens_hsa05215 HSP90AA1, HSP90AB1, PIK3CA, BCL2, PIK3CB, EGFR, IGF1R 5.1971
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP3A4 5.7371
Gap junction_Homo sapiens_hsa04540 PRKCG, GRM5, PRKCB, SRC, PRKCA, GRM1, EGFR 5.2182
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PRKCG, PIK3CA, PRKCB, PRKCE, PRKCD, PRKCA, PIK3CB 5.091
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, GRIA2, CHRM1, PIK3CA, ADORA1, PIK3CB, PPARA, GRIA4 4.7875
Oxytocin signaling pathway_Homo sapiens_hsa04921 PRKCG, PIK3CA, PRKCB, SRC, PRKCA, PIK3CB, PTGS2, EGFR 4.6368
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PRKCG, PIK3CA, PRKCB, SRC, PRKCA, PIK3CB, ESR1 4.5105
Long-term depression_Homo sapiens_hsa04730 PRKCG, GRIA2, PRKCB, PRKCA, GRM1, IGF1R 5.0714
Amphetamine addiction_Homo sapiens_hsa05031 PRKCG, GRIA2, PRKCB, MAOA, PRKCA, GRIA4 4.819
Dopaminergic synapse_Homo sapiens_hsa04728 PRKCG, GRIA2, PRKCB, MAOA, PRKCA, DRD3, GRIA4 4.2741
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PRKCG, PIK3CA, PRKCB, MMP2, PRKCA, PIK3CB, MMP9 4.5105
Long-term potentiation_Homo sapiens_hsa04720 PRKCG, GRIA2, GRM5, PRKCB, PRKCA, GRM1 4.8471
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, PIK3CA, INSR, PIK3CB, GRM1, EGFR, IGF1R 4.1962
Melanoma_Homo sapiens_hsa05218 CDK6, PIK3CA, PIK3CB, MET, EGFR, IGF1R 4.7007
Tight junction_Homo sapiens_hsa04530 PRKCG, CSNK2A1, PRKCB, SRC, PRKCE, PRKCD, PRKCA 4.0885
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, CHRM3, CHRM1, PIK3CA, SRC, CHRM5, PIK3CB, EGFR 3.7937
GnRH signaling pathway_Homo sapiens_hsa04912 PRKCB, SRC, MMP2, PRKCD, PRKCA, EGFR 4.1472
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 HSP90AA1, HSP90AB1, PIK3CA, PIK3CB, CDC25B, IGF1R 3.9801
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, INSR, PPARG, PIK3CB, HMGCR, IGF1R 3.5003
MAPK signaling pathway_Homo sapiens_hsa04010 PRKCG, DUSP3, PRKCB, PRKCA, EGFR, CDC25B, HSPA1A 2.6519
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, INSR, PRKCE, ADORA1, PIK3CB 2.8681
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 2.6231
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.1679
Purine metabolism_Homo sapiens_hsa00230 XDH 0.1752
Alcoholism_Homo sapiens_hsa05034 MAOA 0.1735
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, INSR, PPARG, PIK3CB, IGF1R 3.1363
mTOR signaling pathway_Homo sapiens_hsa04150 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB 3.9578
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.2083
Circadian entrainment_Homo sapiens_hsa04713 PRKCG, GRIA2, PRKCB, PRKCA, GRIA4 3.121
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, INSR, PIK3CB, IGF1R, HSPA1A 3.8365
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.242
Axon guidance_Homo sapiens_hsa04360 MET 0.2549
Amoebiasis_Homo sapiens_hsa05146 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB 3.0352
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.2619
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB 3.07
Pancreatic cancer_Homo sapiens_hsa05212 CDK6, SMAD3, PIK3CA, PIK3CB, EGFR 3.7937
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, PIK3CB, MET, EGFR 3.769
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB, HSPA1A 2.7345
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1, ESR2 3.6459
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, PIK3CA, BCL2, PIK3CB, PTGS2 3.3049
Pancreatic secretion_Homo sapiens_hsa04972 PRKCG, CHRM3, PRKCB, CA2, PRKCA 3.1057
Vascular smooth muscle contraction_Homo sapiens_hsa04270 PRKCG, PRKCB, PRKCE, PRKCD, PRKCA 2.7069
Gastric acid secretion_Homo sapiens_hsa04971 PRKCG, CHRM3, PRKCB, CA2, PRKCA 3.5953
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.3192
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1, PIK3CA, PIK3CB, HSPA1A 2.5046
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB 2.514
Huntington's disease_Homo sapiens_hsa05016 GRM5, PPARG 0.4413
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.3363
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, PIK3CA, ESRRB, PIK3CB, IGF1R 2.4363
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.4804
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1, AOX1, CYP3A4 3.8114
Wnt signaling pathway_Homo sapiens_hsa04310 PRKCG, SMAD3, CSNK2A1, PRKCB, PRKCA 2.4363
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.3539
HTLV-I infection_Homo sapiens_hsa05166 SMAD3, PIK3CA, PIK3CB 0.6029
Protein digestion and absorption_Homo sapiens_hsa04974 SLC1A1 0.3514
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.3668
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.3526
Peroxisome_Homo sapiens_hsa04146 XDH 0.3685
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, MAOA, CYP1A2, AOX1, CYP3A4 3.7212
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, AOX1, PIK3CB 2.2662
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5, ALOX15, ALOX12, PTGS2, PTGS1 3.8959
Bile secretion_Homo sapiens_hsa04976 CA2, SLC22A1, SLC5A1, HMGCR, CYP3A4 3.6684
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB, HSPA1A 1.8636
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.3826
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 0.9686
Influenza A_Homo sapiens_hsa05164 PIK3CA, PRKCB, PRKCA, PIK3CB, HSPA1A 2.0941
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, PPARG, MMP9, MET, IGF1R 2.0509
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARG, PPARA 3.7212
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, PIK3CA, SRC, PIK3CB 1.2638
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 0.7585
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, PRKCB, SRC, PRKCD, PIK3CB 1.9859
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.4216
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, INSR, PRKCE, PRKCD, PIK3CB 4.3869
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 0.766
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSP90AA1, HSP90AB1, BCL2, HSPA1A 1.5133
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB 1.1198
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.4241
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, PIK3CB, PTGS1 1.9352
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PPARG, PIK3CB 1.1728
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.0771
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 4.6949
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, PRKCD, BCL2, PIK3CB 1.9562
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PRKCA, PIK3CB 1.6899
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, INSR, PIK3CB, PPARA 1.6641
Shigellosis_Homo sapiens_hsa05131 SRC 0.4413
Cell cycle_Homo sapiens_hsa04110 CDK6, SMAD3, CDC25B 1.2329
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.4431
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PIK3CA, INSR, PIK3CB 1.7747
Melanogenesis_Homo sapiens_hsa04916 PRKCG, PRKCB, PRKCA, TYR 2.208
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA, EGFR 1.8289
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 0.863
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6, SMAD3, PIK3CA, PIK3CB 2.6299
Morphine addiction_Homo sapiens_hsa05032 PRKCG, PRKCB, ADORA1, PRKCA 2.3388
Taste transduction_Homo sapiens_hsa04742 CHRM3, GRM1 0.9129
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3, PIK3CA, PIK3CB 1.413
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, PRKCB, BCL2, PTGS2 2.3088
Salivary secretion_Homo sapiens_hsa04970 PRKCG, CHRM3, PRKCB, PRKCA 2.3695
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 PRKCG, PRKCB, PRKCE, PRKCA 2.4966
Tryptophan metabolism_Homo sapiens_hsa00380 MAOA, CYP1A2, CYP1A1, AOX1, CYP1B1 4.7298
GABAergic synapse_Homo sapiens_hsa04727 PRKCG, PRKCB, SRC, PRKCA 2.3828
Staphylococcus aureus infection_Homo sapiens_hsa05150 PTAFR 0.4861
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 2.5427
Insulin secretion_Homo sapiens_hsa04911 PRKCG, CHRM3, PRKCB, PRKCA 2.4334
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 PRKCA 0.4901
Leishmaniasis_Homo sapiens_hsa05140 PRKCB, PTGS2 0.9991
Vibrio cholerae infection_Homo sapiens_hsa05110 PRKCA 0.5153
Mineral absorption_Homo sapiens_hsa04978 SLC5A1 0.5153
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOA 0.5174
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.0169
Malaria_Homo sapiens_hsa05144 MET 0.5223
Colorectal cancer_Homo sapiens_hsa05210 SMAD3, PIK3CA, BCL2, PIK3CB 2.8681
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.5272
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, PIM1, PIK3CB 2.9996
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PRKCB, PIK3CB 1.7852
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.5325
Antigen processing and presentation_Homo sapiens_hsa04612 HSP90AA1, HSP90AB1, HSPA1A 1.7296
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PRKCA, PIK3CB 1.8542
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC 1.0809
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 1.8781
Thyroid hormone synthesis_Homo sapiens_hsa04918 PRKCG, PRKCB, PRKCA 1.8142
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 1.8542
NOD-like receptor signaling pathway_Homo sapiens_hsa04621 HSP90AA1, HSP90AB1 1.1728
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.1491
Legionellosis_Homo sapiens_hsa05134 CLK1, HSPA1A 1.1941
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOA 0.5911
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.5911
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.6345
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 PRKCG, PRKCB, PRKCA, ESR1 3.2894
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PRKCB, SLC5A1, PIK3CB 3.3511
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 GRIA2, BCL2 1.2469
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB, EGFR 2.139
Thyroid cancer_Homo sapiens_hsa05216 PPARG 0.6975
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.6765
Base excision repair_Homo sapiens_hsa03410 APEX1 0.6548
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.7201
Cocaine addiction_Homo sapiens_hsa05030 GRM3, GRIA2, MAOA 2.208
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.6975
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.7296
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.6868
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, CYP3A4, XDH 2.2734
Nicotine addiction_Homo sapiens_hsa05033 GRIA2, GRIA4 1.4279
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7201
African trypanosomiasis_Homo sapiens_hsa05143 PRKCG, PRKCB, PRKCA 2.5615
Histidine metabolism_Homo sapiens_hsa00340 MAOA 0.7585
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.6505
Tyrosine metabolism_Homo sapiens_hsa00350 MAOA, AOX1, TYR 2.5615
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.5105
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2, CYP3A4 2.7665
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.6005
Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 HMGCR 0.7852
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOA 0.8817
Other glycan degradation_Homo sapiens_hsa00511 GBA2 0.863
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.8444
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 0.9559
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.2716
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 4.9817


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)