Prescription Description
| Prescription ID | TCMF4492 |
| Pinyin Name | Jiang Tang Ning Jiao Nang |
| Chinese Name | 降糖宁胶囊 |
| English Name | Jiang Tang Ning Capsules |
| Function Description | 消渴 |
| Indications | Wasting thirst disorder, Diabetes |
| Disease ICD-11 Category |
SD71 [Wasting thirst disorder (TM1), 消渴 (TM1)
]; 5A14 [Diabetes mellitus, type unspecified, 糖尿病，未特指类型 ]; |
| Human Tissues Associated with Indication | Pancreas, Blood |
| Reference | CFDA |
| Reference Book/link | http://samr.cfda.gov.cn/WS01/CL0001/ |
Prescription Components
| Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
|---|---|---|---|---|
| TCMH1721 | Panax ginseng | 人参 | TCMH1721 | GBVE1679-11 |
| TCMH1845 | Dioscorea batatas | 山药 | TCMH1845 | |
| TCMH1931 | Gypsum fibrosum | 石膏 | TCMH1931 | |
| TCMH2624 | Anemarrhena asphodeloides | 知母 | TCMH2624 | GBVA3255-11, GBVU1201-13 |
| TCMH981 | Astragalus membranaceus | 黄芪 | TCMH981 | ITSAK2981-14 |
| TCMH2086 | Trichosanthes kirilowii | 天花粉 | TCMH2086 | ITSAO4359-14 |
| TCMH606 | Wolfiporia cocos | 茯苓 | TCMH606 | GBPOL314-13 |
| TCMH1423 | Ophiopogon japonicus | 麦冬 | TCMH1423 | ITSAJ4140-14 |
| TCMH451 | Rehmannia glutinosa | 地黄 | TCMH451 | ITSAH4578-14 |
| TCMH449 | Cortex lycii radicis | 地骨皮 | TCMH449 | |
| TCMH2538 | Zea mays | 玉米须 | TCMH2538 | |
| TCMH1862 | Cornus officinalis | 山茱萸 | TCMH1862 | ITSAO2979-14 |
| TCMH628 | Glycyrrhiza uralensis | 甘草 | TCMH628 | ITSAM892-14 |
Targeted Human Proteins by the Ingredients of Prescription
| Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
|---|---|---|---|---|
| TCMT100 | TTR | Transthyretin | Unclassified | P02766 |
| TCMT101 | PTPN1 | Protein-tyrosine phosphatase 1B | Hydrolase | P18031 |
| TCMT102 | ACP1 | Low molecular weight phosphotyrosine protein phosphatase | Hydrolase | P24666 |
| TCMT103 | PTPRF | Receptor-type tyrosine-protein phosphatase F (LAR) | Hydrolase | P10586 |
| TCMT107 | GRIK2 | Glutamate receptor ionotropic kainate 2 | Ion channel | Q13002 |
| TCMT109 | GRIA2 | Glutamate receptor ionotropic, AMPA 2 | Ion channel | P42262 |
| TCMT110 | GRIA4 | Glutamate receptor ionotropic, AMPA 4 | Ion channel | P48058 |
| TCMT111 | GRIK5 | Glutamate receptor ionotropic kainate 5 | Ion channel | Q16478 |
| TCMT112 | ADORA3 | Adenosine A3 receptor | GPCR | P0DMS8 |
| TCMT127 | PARP1 | Poly [ADP-ribose] polymerase-1 | Transferase | P09874 |
Showing 1 to 10 of 117 entries
Targeted Pathogenic Microbes by the Ingredients of Prescription
| Target ID | Target Name |
|---|---|
| TCMT1170 | Enterobacter cloacae |
| TCMT1172 | Staphylococcus aureus subsp. aureus RN4220 |
| TCMT1175 | Human immunodeficiency virus |
| TCMT1176 | Streptococcus pneumoniae |
| TCMT1178 | Actinomyces viscosus |
| TCMT1179 | Escherichia coli ATCC 8739 |
| TCMT1181 | Mycobacterium tuberculosis H37Ra |
| TCMT1182 | Streptococcus sanguinis |
| TCMT1186 | Plasmodium yoelii yoelii |
| TCMT1189 | Pseudomonas fluorescens |
Showing 1 to 10 of 79 entries
Gene Ontology Associated to Targeted Human Proteins
| GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|---|
| [BP] GO:0000302 | response to reactive oxygen species | AKR1B1, AXL, BCL2, CYP1B1, MMP9, SRC | 2.24664 |
| [BP] GO:0001666 | response to hypoxia | ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SRC | 2.9592 |
| [BP] GO:0001676 | long-chain fatty acid metabolic process | CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2 | 3.32449 |
| [BP] GO:0001932 | regulation of protein phosphorylation | ADORA1, BCL2, CDC25B, FABP4, FLT3, GRM1, GRM5, HMGCR, IGF1R, KDR, MMP9, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 3.07681 |
| [BP] GO:0001934 | positive regulation of protein phosphorylation | ADORA1, BCL2, CDC25B, FLT3, GRM1, GRM5, HMGCR, KDR, MMP9, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH | 3.79104 |
| [BP] GO:0001952 | regulation of cell-matrix adhesion | BCL2, CDK6, KDR, PIK3CB, SRC | 2.30631 |
| [BP] GO:0002237 | response to molecule of bacterial origin | ALPL, AXL, CYP1A1, CYP1A2, IDO1, MAOB, MPO, PTGS2, SRC | 3.34555 |
| [BP] GO:0002682 | regulation of immune system process | ADORA1, AXL, BCL2, CA2, CDK6, CYP19A1, ESR1, ESRRA, HCAR2, IDO1, MMP12, MMP2, PDE5A, PIK3CA, PIK3CB, PTPN1, SRC | 2.16082 |
| [BP] GO:0003006 | developmental process involved in reproduction | ALPL, AXL, BCL2, CDC25B, CYP19A1, ESR1, ESRRB, HSD17B2, PTGS2, SRC | 2.03368 |
| [BP] GO:0006082 | organic acid metabolic process | ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, GBA2, IDO1, MPO, PIM1, PPARA, PTGS1, PTGS2, TYR | 2.59799 |
Showing 1 to 10 of 323 entries
KEGG Pathways Associated to Targeted Human Proteins
| KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|
| Acute myeloid leukemia_Homo sapiens_hsa05221 | PIK3CA, FLT3, PIM1, PIK3CB | 3.3772 |
| Adherens junction_Homo sapiens_hsa04520 | PTPN1, CSNK2A1, SRC, MET, IGF1R | 4.0809 |
| Adipocytokine signaling pathway_Homo sapiens_hsa04920 | PPARA | 0.5596 |
| Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | PIK3CA, BCL2, PIK3CB | 1.4455 |
| African trypanosomiasis_Homo sapiens_hsa05143 | IDO1 | 0.786 |
| AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | PIK3CA, MMP2, BCL2, PIM1, PIK3CB, F3 | 4.5095 |
| Alcoholism_Homo sapiens_hsa05034 | MAOB | 0.2932 |
| Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | HSD11B2, PIK3CA, PIK3CB | 2.7228 |
| Amoebiasis_Homo sapiens_hsa05146 | PIK3CA, PIK3CB | 1.0614 |
| Amphetamine addiction_Homo sapiens_hsa05031 | GRIA2, MAOB, GRIA4 | 2.2557 |
Showing 1 to 10 of 171 entries
Target Exprsssion in Healthy Human Tissues (protein & mRNA level)
Protein expression data was from the "Human Proteome Map" datasetmRNA expression data was from the "GTEx" dataset
Average Target Expression (Fold Change) in Multiple Disease Conditions
Fold Change with Corresponding Normal SamplesClick each cell within the heatmap to access gene expression of individual patient samples