TCM Prescription:



Prescription Description
Prescription IDTCMF7259
Pinyin NameQin Jiao Bie Jia San
Chinese Name秦艽鳖甲散
English Name
Function Description骨蒸潮热, 唇红颊赤, 盗汗咳嗽
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with IndicationLung
ReferenceTaiwan Herbal Pharmacopeia 2nd Edition English Version
Reference Book/linkhttps://www.mohw.gov.tw/cp-3690-39025-2.html
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH178 Carapax trionycis 鳖甲 TCMH178
TCMH1673 Gentiana macrophylla 秦艽 TCMH1673 ITSAO2245-14
TCMH2624 Anemarrhena asphodeloides 知母 TCMH2624 GBVA3255-11, GBVU1201-13
TCMH421 Angelica sinensis 当归 TCMH421 ITSAF173-14
TCMH228 Bupleurum chinense 柴胡 TCMH228 ITSAM2218-14
TCMH449 Cortex lycii radicis 地骨皮 TCMH449
TCMH2191 Prunus mume 乌梅 TCMH2191 ITSAN1052-14
TCMH1681 Artemisia carvifolia 青蒿 TCMH1681 KU555619
Reference: Taiwan Herbal Pharmacopeia 2nd Edition English Version

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT186 MAOB Monoamine oxidase B Oxidoreductase P27338
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT268 CYP2A13 Cytochrome P450 2A13 Oxidoreductase Q16696
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT39 PDE5A Phosphodiesterase 5A Hydrolase O76074
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT598 TOP1 DNA topoisomerase I Isomerase P11387
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1283 Human enterovirus 71
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 12.6968
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.8577
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, FLT3, GPR35, HCAR2, HSPA1A, INSR, KDR, MET, MMP9, PDE5A, PTPN1, SMAD3, SRC, TEK, XDH 8.72614
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, FLT3, GPR35, HCAR2, HSPA1A, INSR, KDR, MET, MMP9, PDE5A, PTPN1, SMAD3, SRC, TEK, XDH 8.72614
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, CDC25B, CSNK2A1, CYP1B1, EGFR, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, PDE5A, PIM1, SMAD3, SRC, TEK, XDH 7.10552
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, DUSP3, EGFR, F10, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PDE5A, PTPN1, SRC, TEK, XDH 7.10552
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, PIM1, SRC, TEK 6.86429
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX5, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1B1, CYP2A13, CYP2A6, FABP3, HSPA1A, PDE5A, PIM1, PPARA, XDH 6.7704
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, F10, FABP3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MMP1, MMP2, MMP9, NUAK1, PDE5A, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP1, XDH 6.75774
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK 6.57908
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, F10, FABP3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MMP1, MMP2, NUAK1, PDE5A, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP1, XDH 6.44937
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, AXL, CYP1B1, EGFR, F10, FLT3, GPR35, HSPA1A, INSR, KDR, MET, PDE5A, PTPN1, SRC, TEK, XDH 6.44937
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, F10, FABP3, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MMP1, MMP2, MMP9, PDE5A, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 6.39095
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, FLT3, HCAR2, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 6.39095
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, F10, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PDE5A, PTPN1, SMAD3, SRC, TEK, XDH 6.3168
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK 6.30091
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, F10, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PDE5A, PTPN1, SMAD3, SRC, TEK, XDH 6.22371
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, AXL, CSNK2A1, CYP1B1, EGFR, F10, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP9, PDE5A, PTPN1, SMAD3, SRC, TEK, XDH 6.20127
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, FLT3, HCAR2, HSPA1A, IGF1R, KDR, MET, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, XDH 6.19447
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 6.19447
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.98825
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALPL, AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PDE5A, PIM1, PTPN1, SRC, TEK, TOP1, XDH 5.95328
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 5.95328
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MMP9, PPARA, PTPN1, SMAD3, SRC, TEK 5.83001
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, F10, FABP3, FABP4, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MMP1, MMP2, MMP9, PDE5A, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 5.81198
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, CA2, CA9, CSNK2A1, EGFR, FABP3, FLT3, IGF1R, INSR, MAOB, MMP2, PPARA, SMAD3, SRC, TEK 5.70521
[BP] GO:0006793 phosphorus metabolic process ACHE, ALPL, AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PDE5A, PIM1, PTPN1, SRC, TEK, TOP1, XDH 5.64933
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, EGFR, HSPA1A, IGF1R, KDR, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK 5.62731
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, EGFR, FLT3, HCAR2, HSPA1A, IGF1R, KDR, MMP9, PIM1, PTPN1, SMAD3, SRC, TEK, XDH 5.5637
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SRC, TEK 5.48935
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 5.28393
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, AXL, CSNK2A1, CYP1B1, EGFR, F10, FABP4, FLT3, GPR35, HSPA1A, INSR, KDR, MET, MMP2, MMP9, PDE5A, PTPN1, SMAD3, SRC, TEK, XDH 5.24157
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1B1, EGFR, F10, FABP3, FABP4, FLT3, GPR35, HCAR2, HSPA1A, INSR, KDR, MAOB, MET, PPARA, SMAD3, SRC, TEK, XDH 5.19706
[BP] GO:0009725 response to hormone AKR1B1, ALPL, CA2, CA9, CSNK2A1, EGFR, FABP3, FLT3, INSR, MAOB, PPARA, SRC, TEK 5.1875
[BP] GO:0006468 protein phosphorylation AURKB, AXL, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1 5.18425
[BP] GO:0010033 response to organic substance AKR1B1, ALPL, AXL, CA2, CA9, CSNK2A1, CYP1B1, EGFR, FABP3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MAOB, MMP2, PPARA, SMAD3, SRC, TEK 5.18425
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, FABP3, PPARA 5.14815
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK 5.10677
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 5.01561
[BP] GO:0042221 response to chemical AKR1B1, ALPL, AXL, CA2, CA9, CSNK2A1, CYP1B1, EGFR, FABP3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MAOB, MMP2, MMP9, PPARA, SMAD3, SRC, TEK, TOP1 5.00992
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, CDC25B, DUSP3, EGFR, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, NUAK1, PDE5A, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 4.68881
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, CDC25B, DUSP3, EGFR, FABP3, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, NUAK1, PDE5A, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 4.64077
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.62569
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, CYP19A1, CYP1B1, EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.61505
[BP] GO:0051896 regulation of protein kinase B signaling AXL, EGFR, F10, INSR, MET, SRC, TEK, XDH 4.49358
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, AXL, CA9, CSNK2A1, CYP1B1, EGFR, FABP3, IGF1R, INSR, MAOB, MMP2, MMP9, PPARA, SRC, TEK 4.30899
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, EGFR, F10, INSR, MET, SRC, TEK 4.25482
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 4.25482
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, F10, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP2, MMP9, NUAK1, PDE5A, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 4.16388
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, INSR, MET, SMAD3, SRC 4.15805
[BP] GO:0016310 phosphorylation AURKB, AXL, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1 4.13758
[BP] GO:0030335 positive regulation of cell migration EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.124
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1B1, CYP2A13, CYP2A6 4.11217
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, FLT3, IGF1R, INSR, PDE5A, PTPN1, SRC 4.0848
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, DUSP3, EGFR, F10, FLT3, GPR35, HSPA1A, IGF1R, INSR, KDR, MET, MMP9, NUAK1, PDE5A, PTPN1, SMAD3, SRC, TEK, XDH 4.04793
[BP] GO:2000147 positive regulation of cell motility EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 4.0239
[BP] GO:0043408 regulation of MAPK cascade ADORA1, DUSP3, EGFR, FLT3, IGF1R, INSR, KDR, PDE5A, PTPN1, SRC, TEK, XDH 4.01812
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, AURKB, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, FABP4, FLT3, GPR35, HSPA1A, IGF1R, INSR, MET, MMP9, NUAK1, PDE5A, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 4.0147
[BP] GO:0010035 response to inorganic substance AKR1B1, AXL, CA2, CYP1B1, EGFR, FABP4, KDR, MAOB, MMP9, SRC 4.00606
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, CSNK2A1, EGFR, F10, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK, TOP1 3.95864
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, CSNK2A1, CYP19A1, CYP1B1, CYP2A13, CYP2A6, EGFR, FABP3, FABP4, MET, PPARA 3.95864
[BP] GO:0051272 positive regulation of cellular component movement EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.94548
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 3.93892
[BP] GO:0040017 positive regulation of locomotion EGFR, F10, IGF1R, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 3.82045
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AXL, CYP19A1, CYP1B1, DUSP3, EGFR, F10, FABP4, IGF1R, INSR, MET, MMP1, MMP2, MMP9, PDE5A, PIM1, PPARA, SMAD3, SRC, TEK, TOP1 3.80977
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1B1, CYP2A6, FABP3, FABP4, HSPA1A, MAOB, MMP1, MMP2, MMP9, PDE5A, SRC, XDH 3.77694
[BP] GO:0080134 regulation of response to stress ADORA1, CYP19A1, DUSP3, EGFR, FABP4, HSPA1A, IGF1R, MET, MMP2, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 3.69842
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 3.69842
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, CDC25B, EGFR, FABP3, FLT3, INSR, KDR, MMP9, PDE5A, PTPN1, SMAD3, SRC, TEK, XDH 3.69842
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, CDC25B, EGFR, FABP3, FLT3, INSR, KDR, MMP9, PDE5A, PTPN1, SMAD3, SRC, TEK, XDH 3.69842
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, AURKB, CDC25B, CSNK2A1, DUSP3, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, MMP9, NUAK1, PDE5A, PTPN1, SMAD3, SRC, TEK, XDH 3.69127
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, EGFR, FLT3, INSR, KDR, PDE5A, PTPN1, SRC, TEK, XDH 3.68239
[BP] GO:0042325 regulation of phosphorylation ADORA1, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, PDE5A, PPARA, PTPN1, SRC, TEK, XDH 3.55673
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CSNK2A1, CYP1B1, DUSP3, FABP4, GPR35, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC 3.4306
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, AXL, CA12, CA2, CA7, EGFR, FABP3, FABP4, FLT3, GPR35, INSR, MET, SMAD3, SRC 3.38786
[BP] GO:0043549 regulation of kinase activity ADORA1, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, PDE5A, PTPN1, SRC, TEK 3.35979
[BP] GO:0051338 regulation of transferase activity ADORA1, AURKB, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, PDE5A, PTPN1, SRC, TEK 3.34795
[BP] GO:0031399 regulation of protein modification process ADORA1, CDC25B, DUSP3, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PDE5A, PTPN1, SRC, TEK, XDH 3.34795
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MMP9, PDE5A, PTPN1, SRC, TEK, XDH 3.33018
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, ALPL, AURKB, AXL, CA2, CA6, CA9, CSNK2A1, CYP1B1, EGFR, F10, FABP3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MAOB, MMP2, MMP9, NUAK1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP1 3.30412
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, CDC25B, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP2, MMP9, PIM1, TEK 3.19864
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, GPR35, HSPA1A, IGF1R, KDR, MAOB, MET, MMP9, PDE5A, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 3.16902
[BP] GO:0051049 regulation of transport ACHE, ADORA1, AXL, CA2, CA7, CYP19A1, EGFR, GPR35, HCAR2, HSPA1A, INSR, MAOB, MMP9, PPARA, PTPN1, SMAD3, SRC 3.08783
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, F10, FLT3, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MMP1, MMP2, MMP9, NUAK1, PDE5A, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP1, XDH 3.01934
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.99208
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALPL, AXL, CYP1B1, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, SMAD3, SRC 2.98239
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, CDC25B, EGFR, FLT3, INSR, KDR, MMP9, PDE5A, PTPN1, SRC, TEK, XDH 2.93678
[BP] GO:0031347 regulation of defense response ADORA1, CYP19A1, EGFR, FABP4, HSPA1A, MMP2, PPARA, PTPN1, SMAD3, SRC, TEK 2.92255
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, EGFR, FLT3, INSR, PDE5A, PTPN1, SRC 2.92026
[BP] GO:0045859 regulation of protein kinase activity ADORA1, CDC25B, DUSP3, EGFR, FABP4, FLT3, IGF1R, INSR, PDE5A, PTPN1, SRC 2.91965
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, DUSP3, EGFR, FLT3, IGF1R, INSR, PDE5A, PTPN1, SRC 2.90187
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, CYP1B1, EGFR, MMP9, SRC 2.90051
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, AXL, CA1, CSNK2A1, EGFR, FLT3, GPR35, IGF1R, INSR, KDR, MET, MMP2, MMP9, PTPN1, SMAD3, SRC, TEK 2.90051
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALPL, AURKB, AXL, CA2, CA9, CYP1B1, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP2, MMP9, NUAK1, PTPN1, SMAD3, SRC 2.90051
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX5, CSNK2A1, CYP1B1, CYP2A13, CYP2A6, EGFR, FABP3, FABP4, MET, PPARA 2.90051
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.90051
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, MET, SRC 2.90051
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, MET, SRC 2.90051
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, MET, SRC 2.90051
[BP] GO:1901654 None AKR1B1, CA9, CSNK2A1, EGFR, MAOB, SRC 2.8762
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FABP3, FABP4, GPR35, HCAR2, HSPA1A, IGF1R, KDR, MAOB, MET, MMP9, PDE5A, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 2.86831
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, CDC25B, EGFR, FLT3, INSR, KDR, MMP9, PDE5A, PTPN1, SRC, TEK, XDH 2.80414
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CSNK2A1, CYP19A1, EGFR, FLT3, INSR, KDR, PPARA, SMAD3, SRC, TEK 2.73605
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, EGFR, FLT3, INSR, PDE5A, PTPN1, SRC, TEK 2.71015
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.679
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.679
[BP] GO:0001503 ossification ALPL, EGFR, MMP2, MMP9, TEK 2.67285
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, EGFR, FLT3, INSR, PDE5A, PTPN1, SRC, TEK 2.67052
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CYP19A1, PPARA, SMAD3, TEK 2.66058
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALPL, AXL, CYP1B1, EGFR, FABP4, FLT3, IGF1R, INSR, KDR, MMP2, SMAD3, SRC 2.64216
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, CDC25B, CSNK2A1, EGFR, FLT3, HSPA1A, INSR, KDR, MMP9, PDE5A, PTPN1, SMAD3, SRC, TEK, XDH 2.62768
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.60336
[BP] GO:0033993 response to lipid ALPL, AXL, CA2, CA9, CSNK2A1, EGFR, FABP3, FLT3, MAOB, SRC 2.5517
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, SRC, TEK 2.54541
[BP] GO:0014070 response to organic cyclic compound ALPL, CA2, CA9, CSNK2A1, CYP1B1, EGFR, FLT3, MAOB, SRC, TEK 2.53751
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.52046
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, SRC, TEK 2.52046
[BP] GO:0042493 response to drug AKR1B1, AXL, CA9, CYP1B1, EGFR, FABP3, KDR, MAOB, SRC, TOP1 2.49508
[BP] GO:0019373 epoxygenase P450 pathway CYP1B1, CYP2A13, CYP2A6 2.48133
[BP] GO:0048545 response to steroid hormone ALPL, CA2, EGFR, FLT3, MAOB, SRC 2.44758
[BP] GO:0009894 regulation of catabolic process ADORA1, CSNK2A1, EGFR, HCAR2, HSPA1A, INSR, KDR, MET, PPARA, PTPN1, SMAD3 2.44758
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, DUSP3, EGFR, GPR35, HSPA1A, IGF1R, MET, MMP9, PTPN1, SMAD3, SRC, XDH 2.44758
[BP] GO:0019538 protein metabolic process ACHE, ALPL, AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, F10, FLT3, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP1 2.44407
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, CYP19A1, DUSP3, EGFR, HSPA1A, IGF1R, MET, MMP9, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 2.44346
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, DUSP3, EGFR, GPR35, HSPA1A, IGF1R, MET, MMP9, PTPN1, SMAD3, SRC, XDH 2.44142
[BP] GO:0044419 interspecies interaction between organisms AXL, EGFR, HSPA1A, INSR, KDR, MET, MMP1, SMAD3, SRC, TOP1 2.43752
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALPL, AURKB, AXL, CA2, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FABP4, FLT3, INSR, KDR, MAOB, MET, MMP2, MMP9, PIM1, PPARA, SMAD3, SRC, TEK 2.40367
[BP] GO:0010243 response to organonitrogen compound AKR1B1, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, SRC, TEK 2.40367
[BP] GO:0044267 cellular protein metabolic process ALPL, AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, F10, FLT3, IGF1R, INSR, KDR, MET, MMP1, MMP2, NUAK1, PIM1, PTPN1, SMAD3, SRC, TEK, TOP1 2.35918
[BP] GO:0010638 positive regulation of organelle organization AURKB, HSPA1A, INSR, KDR, MET, MMP9, SMAD3, SRC, TEK 2.35653
[BP] GO:0006979 response to oxidative stress AKR1B1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, SRC 2.35528
[BP] GO:0048878 chemical homeostasis AKR1B1, CA12, CA2, CA7, EGFR, FABP3, FABP4, GPR35, INSR, MET, SMAD3 2.35528
[BP] GO:0051894 None KDR, SMAD3, TEK 2.35137
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, CA2, CA7, EGFR, HCAR2, KDR, SRC 2.34304
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, AURKB, CDC25B, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MMP9, PDE5A, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 2.34208
[BP] GO:0044093 positive regulation of molecular function ADORA1, AURKB, CDC25B, EGFR, FLT3, HSPA1A, INSR, MET, MMP9, PDE5A, PTPN1, SMAD3, SRC, TEK, XDH 2.34055
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, CDC25B, EGFR, FLT3, HSPA1A, INSR, KDR, MMP9, PDE5A, PTPN1, SMAD3, SRC, TEK, XDH 2.34055
[BP] GO:0051240 positive regulation of multicellular organismal process AXL, CA2, CYP1B1, EGFR, HCAR2, HSPA1A, KDR, MET, MMP9, PDE5A, PIM1, SMAD3, SRC, TEK 2.33359
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, CDC25B, CSNK2A1, DUSP3, EGFR, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MMP9, NUAK1, PDE5A, PTPN1, SMAD3, SRC, TEK, XDH 2.32935
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, F10, FABP3, FABP4, FLT3, GPR35, HCAR2, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MMP1, MMP2, MMP9, NUAK1, PDE5A, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP1, XDH 2.32935
[BP] GO:1901652 response to peptide AKR1B1, FABP3, IGF1R, INSR, PPARA, SRC, TEK 2.32935
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, EGFR, FLT3, INSR, PDE5A, PTPN1, SRC 2.31598
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALPL, AXL, CA2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, FLT3, INSR, KDR, MAOB, MMP9, PIM1, PPARA, SMAD3, SRC, TEK 2.31293
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, SRC, TEK 2.30872
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.30547
[BP] GO:1903393 None KDR, SMAD3, TEK 2.27537
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, FABP3, FLT3, HCAR2, PPARA, SRC, TEK 2.23523
[BP] GO:0051130 positive regulation of cellular component organization AURKB, AXL, HSPA1A, IGF1R, INSR, KDR, MET, MMP1, MMP9, SMAD3, SRC, TEK 2.23007
[BP] GO:0031100 animal organ regeneration AXL, CSNK2A1, EGFR, FLT3 2.23007
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, MMP2, MMP9 2.23007
[BP] GO:1901698 response to nitrogen compound AKR1B1, EGFR, FABP3, FLT3, IGF1R, INSR, MMP2, PPARA, SRC, TEK 2.18825
[BP] GO:0009893 positive regulation of metabolic process ADORA1, AURKB, CDC25B, CSNK2A1, EGFR, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MMP9, PDE5A, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 2.18784
[BP] GO:0031960 response to corticosteroid ALPL, EGFR, FLT3, MAOB, SRC 2.17981
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, CA2, EGFR, HSPA1A, MMP2, PPARA, SMAD3, SRC, TEK 2.17486
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, EGFR, INSR, MAOB, SMAD3 2.17486
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, AURKB, CDC25B, EGFR, FABP3, FLT3, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MMP9, PDE5A, PPARA, PTPN1, SMAD3, SRC, TEK, XDH 2.16125
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, EGFR, FLT3, INSR, PDE5A, PTPN1, SRC 2.16125
[BP] GO:0001666 response to hypoxia ADORA1, MMP2, PPARA, SMAD3, SRC, TEK 2.15003
[BP] GO:1902532 negative regulation of intracellular signal transduction DUSP3, HSPA1A, IGF1R, MET, MMP9, PTPN1, SRC, XDH 2.15003
[BP] GO:0030155 regulation of cell adhesion CYP1B1, DUSP3, KDR, NUAK1, PDE5A, PPARA, SMAD3, SRC, TEK 2.15003
[BP] GO:0031401 positive regulation of protein modification process ADORA1, CDC25B, EGFR, FLT3, INSR, KDR, MMP9, PDE5A, PTPN1, SRC, TEK, XDH 2.13332
[BP] GO:1901888 regulation of cell junction assembly KDR, SMAD3, SRC, TEK 2.13332
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, SRC, TEK 2.13111
[BP] GO:0009895 negative regulation of catabolic process ADORA1, EGFR, HCAR2, MET, PPARA, SMAD3 2.12404
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, AURKB, CDC25B, EGFR, FLT3, HSPA1A, INSR, PDE5A, PTPN1, SMAD3, SRC, TEK, XDH 2.1057
[BP] GO:0050727 regulation of inflammatory response ADORA1, CYP19A1, EGFR, FABP4, PPARA, SMAD3, TEK 2.10324
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CYP1B1, CYP2A6, EGFR, HSPA1A, MAOB 2.10288
[BP] GO:1901890 None KDR, SMAD3, TEK 2.10213
[BP] GO:0036293 response to decreased oxygen levels ADORA1, MMP2, PPARA, SMAD3, SRC, TEK 2.10213
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1B1, FABP3, FABP4 2.07938
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7 2.06847
[BP] GO:0006464 cellular protein modification process ALPL, AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, F10, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, SMAD3, SRC, TEK, TOP1 2.06847
[BP] GO:0036211 protein modification process ALPL, AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, F10, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PTPN1, SMAD3, SRC, TEK, TOP1 2.06847
[BP] GO:2000377 regulation of reactive oxygen species metabolic process CYP1B1, EGFR, INSR, SMAD3, XDH 2.05582
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade DUSP3, EGFR, KDR, PTPN1, SRC, TEK 2.05406
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, AXL, CA2, CYP1B1, EGFR, GPR35, HCAR2, HSPA1A, INSR, KDR, MET, MMP9, PDE5A, PIM1, SMAD3, SRC, TEK, XDH 2.04583
[BP] GO:0090218 positive regulation of lipid kinase activity FLT3, SRC, TEK 2.04136
[BP] GO:0010907 None INSR, PPARA, SRC 2.04136
[BP] GO:0031348 negative regulation of defense response ADORA1, CYP19A1, PPARA, SMAD3, TEK 2.04136
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, CYP1B1, KDR, MAOB, SRC 2.04061
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process EGFR, INSR, SMAD3, XDH 2.02511
[BP] GO:0002009 morphogenesis of an epithelium CA2, CA9, EGFR, MET, SMAD3, SRC 2.00999
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, EGFR, KDR, SRC 2.00999
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, TEK 2.77689
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CSNK2A1, EGFR, F10, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, MMP2, PIM1, PTPN1, SMAD3, SRC, TEK 2.58532
[CC] GO:0097443 sorting endosome KDR, PTPN1 2.00999
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, AXL, CA2, CA4, CA9, DUSP3, EGFR, F10, FLT3, GPR35, IGF1R, INSR, KDR, MET, SRC, TEK 1.54722
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, AXL, CA4, F10, FLT3, GPR35, IGF1R, INSR, KDR, MET, TEK 1.54299
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 18.288
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CDC25B, CSNK2A1, CYP19A1, CYP1B1, CYP2A13, CYP2A6, DUSP3, EGFR, F10, FLT3, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MMP1, MMP2, MMP9, NUAK1, PDE5A, PIM1, PTPN1, SRC, TEK, TOP1, XDH 12.2233
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 11.9359
[MF] GO:0043167 ion binding ACHE, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CSNK2A1, CYP19A1, CYP1B1, CYP2A13, CYP2A6, EGFR, F10, FABP3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, MMP1, MMP2, MMP9, NUAK1, PDE5A, PIM1, PPARA, PTPN1, SMAD3, SRC, TEK, TOP1, XDH 10.795
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 10.7438
[MF] GO:0046914 transition metal ion binding ALOX5, CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1B1, CYP2A13, CYP2A6, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, SMAD3, XDH 10.552
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 8.02662
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, TEK 7.192
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9 7.10552
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, MET, SRC, TEK 6.06705
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1 6.06705
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, MMP1, MMP2, MMP9, PPARA, PTPN1, SMAD3 5.88002
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, CYP2A13, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, PPARA, SRC, TEK, TOP1 5.42236
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1 5.21879
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1 4.8123
[MF] GO:0043169 cation binding ACHE, ALOX5, ALPL, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1B1, CYP2A13, CYP2A6, F10, MMP1, MMP2, MMP9, NUAK1, PDE5A, PIM1, PPARA, PTPN1, SMAD3, XDH 4.45122
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MMP9, PIM1, PPARA, PTPN1, SMAD3, SRC 4.13758
[MF] GO:0046872 metal ion binding ALOX5, ALPL, AURKB, CA1, CA12, CA14, CA2, CA4, CA5A, CA5B, CA6, CA7, CA9, CYP19A1, CYP1B1, CYP2A13, CYP2A6, F10, MMP1, MMP2, MMP9, NUAK1, PDE5A, PIM1, PPARA, PTPN1, SMAD3, XDH 4.0848
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, F10, FLT3, IGF1R, INSR, KDR, MET, MMP1, MMP2, MMP9, NUAK1, PIM1, PTPN1, SRC, TEK, TOP1 4.0848
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1 4.05387
[MF] GO:0036094 small molecule binding ADORA1, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, NUAK1, PDE5A, PIM1, SRC, TEK, TOP1, XDH 3.92562
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1B1, CYP2A13, CYP2A6 3.77694
[MF] GO:0032403 protein complex binding ACHE, ADORA1, EGFR, FLT3, IGF1R, INSR, KDR, MMP9, PPARA, PTPN1, SMAD3, SRC 3.64674
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR 3.46464
[MF] GO:0043168 anion binding AURKB, AXL, CSNK2A1, EGFR, F10, FABP3, FABP4, FLT3, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, NUAK1, PDE5A, PIM1, SRC, TEK, TOP1, XDH 3.20873
[MF] GO:0005506 iron ion binding ALOX5, CYP19A1, CYP1B1, CYP2A13, CYP2A6, XDH 3.05908
[MF] GO:0000166 nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, NUAK1, PDE5A, PIM1, SRC, TEK, TOP1, XDH 3.02679
[MF] GO:1901265 nucleoside phosphate binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MAOB, MET, NUAK1, PDE5A, PIM1, SRC, TEK, TOP1, XDH 3.02679
[MF] GO:0005524 ATP binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1 3.01777
[MF] GO:0032559 adenyl ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1 2.91965
[MF] GO:0008389 None CYP2A13, CYP2A6 2.90051
[MF] GO:0030554 adenyl nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1 2.90051
[MF] GO:0032555 purine ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PDE5A, PIM1, SRC, TEK, TOP1 2.57753
[MF] GO:0017076 purine nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PDE5A, PIM1, SRC, TEK, TOP1 2.54834
[MF] GO:0032553 ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PDE5A, PIM1, SRC, TEK, TOP1 2.54541
[MF] GO:0020037 heme binding CYP19A1, CYP1B1, CYP2A13, CYP2A6, SRC 2.47914
[MF] GO:0019838 growth factor binding EGFR, IGF1R, INSR, KDR, TEK 2.44946
[MF] GO:0097367 carbohydrate derivative binding ADORA1, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PDE5A, PIM1, SRC, TEK, TOP1 2.39338
[MF] GO:0070330 aromatase activity CYP19A1, CYP1B1, CYP2A13 2.39338
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1B1, CYP2A13, CYP2A6, SRC 2.35918
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, EGFR, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, PPARA, TEK 2.22005
[MF] GO:0035639 purine ribonucleoside triphosphate binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, MET, NUAK1, PIM1, SRC, TEK, TOP1 2.19212
[MF] GO:0043548 phosphatidylinositol 3-kinase binding AXL, IGF1R, INSR 2.16125
[MF] GO:0043559 insulin binding IGF1R, INSR 2.13111
[MF] GO:0019902 phosphatase binding EGFR, MET, PPARA, PTPN1, SMAD3 2.10213
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.10213
[MF] GO:0042562 hormone binding ACHE, EGFR, IGF1R, INSR 2.09482
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, EGFR, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, TEK 2.03628
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, EGFR, FLT3, GPR35, HCAR2, IGF1R, INSR, KDR, MET, TEK 2.03628
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP2A13, CYP2A6 2.01316
[MF] GO:0004064 arylesterase activity CA1, CA2 2.00999


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA5B, CA5A, CA2, CA4, CA7, CA6, CA9, CA14 19.8306
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MET, EGFR, IGF1R 8.9678
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9, EGFR 5.5072
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, CYP1B1, CYP19A1, IGF1R 5.1885
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, EGFR, IGF1R 4.6036
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, INSR, KDR, TEK, MET, EGFR, IGF1R 4.5704
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KDR, MET, EGFR, IGF1R, HSPA1A 4.0472
Pathways in cancer_Homo sapiens_hsa05200 SMAD3, FLT3, MMP1, MMP2, MMP9, MET, EGFR, IGF1R 3.9212
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9, EGFR, HSPA1A 4.0029
Ras signaling pathway_Homo sapiens_hsa04014 INSR, KDR, TEK, MET, EGFR, IGF1R 3.4426
MicroRNAs in cancer_Homo sapiens_hsa05206 PIM1, CYP1B1, MMP9, MET, EGFR, CDC25B 2.9094
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.4133
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 INSR, KDR, TEK, MET, EGFR, IGF1R 2.6745
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, MET, EGFR, IGF1R 2.7918
HIF-1 signaling pathway_Homo sapiens_hsa04066 INSR, TEK, EGFR, IGF1R 2.8377
FoxO signaling pathway_Homo sapiens_hsa04068 SMAD3, INSR, EGFR, IGF1R 2.4985
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, INSR, ADORA1 2.4985
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 INSR, IGF1R, HSPA1A 2.3513
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, INSR, ADORA1, PDE5A 2.2754
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET, EGFR 2.3178
Melanoma_Homo sapiens_hsa05218 MET, EGFR, IGF1R 2.2833
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR 2.3178
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.1744
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, MMP2, PIM1 1.9622
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CYP2A6, CYP2A13, CYP1B1 2.2754
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, EGFR 2.0764
MAPK signaling pathway_Homo sapiens_hsa04010 DUSP3, EGFR, CDC25B, HSPA1A 1.7587
Chemical carcinogenesis_Homo sapiens_hsa05204 CYP2A6, CYP2A13, CYP1B1 2.1744
Insulin resistance_Homo sapiens_hsa04931 PTPN1, INSR, PPARA 1.8972
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET, EGFR 1.7247
Hepatitis B_Homo sapiens_hsa05161 SMAD3, SRC, MMP9 1.6312
Metabolic pathways_Homo sapiens_hsa01100 CYP2A6, AKR1B10, MAOB, ALOX5, ALPL, AKR1B1, CYP19A1, XDH 1.3793
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, ADORA1, PPARA 1.3592
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.4694
Glioma_Homo sapiens_hsa05214 EGFR, IGF1R 1.4025
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.445
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 GPR35, ADORA3, ADORA1 1.0652
Pancreatic cancer_Homo sapiens_hsa05212 SMAD3, EGFR 1.3999
ErbB signaling pathway_Homo sapiens_hsa04012 SRC, EGFR 1.2201
Prostate cancer_Homo sapiens_hsa05215 EGFR, IGF1R 1.219
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.1662
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 INSR, IGF1R 1.1916
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.4624
Serotonergic synapse_Homo sapiens_hsa04726 MAOB, ALOX5 1.0675
Gap junction_Homo sapiens_hsa04540 SRC, EGFR 1.2196
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.3002
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, MAOB 1.3793
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 1.2184
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, HSPA1A 1.0568
Steroid hormone biosynthesis_Homo sapiens_hsa00140 CYP1B1, CYP19A1 1.4658
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 1.0568
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, ADORA1 1.0508
AMPK signaling pathway_Homo sapiens_hsa04152 INSR, IGF1R 1.0393
Measles_Homo sapiens_hsa05162 CSNK2A1, HSPA1A 0.9876
Hepatitis C_Homo sapiens_hsa05160 PPARA, EGFR 0.9983
Cell cycle_Homo sapiens_hsa04110 SMAD3, CDC25B 1.0393
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, INSR 0.9842
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 SMAD3, IGF1R 0.9805
Wnt signaling pathway_Homo sapiens_hsa04310 SMAD3, CSNK2A1 0.9805
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 INSR, PPARA 0.9454
Phospholipase D signaling pathway_Homo sapiens_hsa04072 INSR, EGFR 0.9759
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.9842
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC, EGFR 0.923
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.6312
Tryptophan metabolism_Homo sapiens_hsa00380 MAOB, CYP1B1 1.7247
Purine metabolism_Homo sapiens_hsa00230 PDE5A, XDH 0.8592
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, HSPA1A 0.7796
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 SRC, EGFR 0.7486
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.9007
HTLV-I infection_Homo sapiens_hsa05166 SMAD3 0.3086
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.7854
Viral carcinogenesis_Homo sapiens_hsa05203 SRC 0.3786
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 HSPA1A 0.421
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.4065
Calcium signaling pathway_Homo sapiens_hsa04020 EGFR 0.4126
Tuberculosis_Homo sapiens_hsa05152 SRC 0.4126
Alcoholism_Homo sapiens_hsa05034 MAOB 0.4126
Influenza A_Homo sapiens_hsa05164 HSPA1A 0.4126
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIM1 0.4412
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.4492
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.406
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.4934
Platelet activation_Homo sapiens_hsa04611 SRC 0.5143
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.5143
Axon guidance_Homo sapiens_hsa04360 MET 0.506
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.5418
Dopaminergic synapse_Homo sapiens_hsa04728 MAOB 0.5038
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.8732
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.5226
Cholinergic synapse_Homo sapiens_hsa04725 ACHE 0.5418
Choline metabolism in cancer_Homo sapiens_hsa05231 EGFR 0.5666
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3 0.5591
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5666
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC 0.5706
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5748
Morphine addiction_Homo sapiens_hsa05032 ADORA1 0.5835
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5746
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1 0.5791
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5887
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.5986
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5887
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5882
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0852
Chronic myeloid leukemia_Homo sapiens_hsa05220 SMAD3 0.6328
Peroxisome_Homo sapiens_hsa04146 XDH 0.5993
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.6341
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.6317
Complement and coagulation cascades_Homo sapiens_hsa04610 F10 0.6144
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.6366
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.6203
Bile secretion_Homo sapiens_hsa04976 CA2 0.6353
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.6511
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6568
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.6527
Amphetamine addiction_Homo sapiens_hsa05031 MAOB 0.6496
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6 0.6527
Colorectal cancer_Homo sapiens_hsa05210 SMAD3 0.6531
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3 0.6527
Shigellosis_Homo sapiens_hsa05131 SRC 0.6527
Non-small cell lung cancer_Homo sapiens_hsa05223 EGFR 0.6796
Arachidonic acid metabolism_Homo sapiens_hsa00590 ALOX5 0.6531
Endometrial cancer_Homo sapiens_hsa05213 EGFR 0.6998
Legionellosis_Homo sapiens_hsa05134 HSPA1A 0.6819
Malaria_Homo sapiens_hsa05144 MET 0.7138
Cocaine addiction_Homo sapiens_hsa05030 MAOB 0.7138
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOB 0.7106
Type II diabetes mellitus_Homo sapiens_hsa04930 INSR 0.7138
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 INSR 0.7796
Prion diseases_Homo sapiens_hsa05020 HSPA1A 0.815
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOB 0.7762
Tyrosine metabolism_Homo sapiens_hsa00350 MAOB 0.815
Dorso-ventral axis formation_Homo sapiens_hsa04320 EGFR 0.9062
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, XDH 3.1231
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.9062
Histidine metabolism_Homo sapiens_hsa00340 MAOB 0.9382
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOB 1.026
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0652


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)