Component: Sargassum 海藻


Description of the Component

Component ID
TCMH797
Latin Name
Sargassum
English Name
seaweed
Chinese Pinyin Name
Hai Zao
中文名
海藻
TCM Properties
Cold,Salty
TCM Meridians
Stomach,Kidney
Therapeutic Class English
For desolving phlegm, stopping cougth, and soothing breathing
Therapeutic Class Chinese
化痰止咳平喘
Functions
soften indurated mass, eliminate phlegm and dissipate modulation, and induce diuresis
Toxicity
NA
Geo-authentic habitats (道地产区)
NA
Reference
Chinese Pharmacopoeia (2015)
Barcode ID
Barcode Source

TCM Prescriptions with the Component

Prescription ID Prescription English Name Prescription Chinese Name
TCMF2434 Added Flavor DFZ Heat Clearing Decoction 加味地肤子汤
TCMFx2418 Bolus of Citri Grandis 橘核丸
TCMF2452 Breast Scleroma Desolving Decoction 乳块消汤
TCMF2414 Decoction of Sargassum for Gortier 海藻玉壶汤
TCMFx1972 fructus Crataegi Turbid Removing Decoction
TCMFx6861 Fu Fang Fu Rong Ye Ding 复方芙蓉叶酊
TCMF3287 Gong Yan Kang Granules 宫炎康颗粒
TCMF4319 He Luo Shu Gan Capsules 和络舒肝胶囊
TCMF4327 He Luo Shu Gan Tablets 和络舒肝片
TCMFx2185 Hyperthyroidism Reduction Bolus
TCMF4664 Ji Sheng Ju He Pills 济生橘核丸
TCMFx4728 Ju He Pills 橘核丸
TCMFx7366 Ju He Pills 橘核丸
TCMFx2553 KH Stone Removing Decoction 昆海排石汤
TCMF2519 Liver Soothing and Stagnation Desolving Recipe 疏肝散结方
TCMFx2425 Lump Desolving Fries 小营煎
TCMF4845 Nei Xiao Luo Li Pills 内消瘰疬丸
TCMF330 Nei Xiao Luo Li Tablet 内消瘰疬片
TCMF4838 Nei Xiao Luo Li Tablets 内消瘰疠片
TCMFx1937 Powder of Concha Ostreae and Alismatis 牡蛎泽泻散
TCMFx5135 Qing Shen Xiao Pang Pills 轻身消胖丸
TCMF5655 Ru He San Jie Tablets 乳核散结片
TCMF655 Ru Ji Ling Granules 乳疾灵颗粒
TCMF5663 Ru Ji Ling Granules 乳疾灵颗粒
TCMF7 Ru Kang Capsule 乳康胶囊
TCMF6 Ru Kang Pills 乳康丸
TCMF5670 Ru Kang Tablets 乳康片
TCMF657 Ru Pi Xiao Capsule 乳癖消胶囊
TCMF658 Ru Pi Xiao Granules 乳癖消颗粒
TCMF5721 Ruan Jian Yao Decoction 软坚药水
TCMF654 Ru He San Jie Tablet 乳核散结片
TCMFx2094 Rupixiao Tablets 乳癖消片
TCMFx1329 Rupixiao Tablets 乳癖消片
TCMFx2391 Sargassum Tumor Reduction Decoction 海藻消瘿汤
TCMF5198 Tui Zhang Yan Ointment 退障眼膏
TCMFx2150 Tumor Removing Decoction 消瘿汤
TCMFx5386 Wu Hai Pills 五海丸
TCMFx5394 Wu Hai Ying Liu Pills 五海瘿瘤丸
TCMF6053 Xiao He Tablets 消核片
TCMFx958 Xiao Ying Pills 消瘿丸
TCMFx6433 Xiao Ying Qi Luo Pills 消瘿气瘰丸
TCMFx6439 Xiao Ying Wu Hai Pills 消瘿五海丸
TCMF383 Xin Tong Oral Liquid 心通口服液
TCMFx2592 Ying Treasure Fries
TCMFx6048 Zhang Yi Powder 障翳散
TCMFx1130 Zhang Yi Powder 障翳散

Targeted Human Proteins by the Ingredient of Component

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT1 EHMT2 Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 Transferase Q96KQ7
TCMT11 HIF1A Hypoxia-inducible factor 1 alpha Transcription factor Q16665
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT125 GBA Beta-glucocerebrosidase Hydrolase P04062
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT132 BCHE Butyrylcholinesterase Hydrolase P06276
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT139 CA6 Carbonic anhydrase VI Lyase P23280
TCMT140 CA5B Carbonic anhydrase VB Lyase Q9Y2D0
TCMT141 CA5A Carbonic anhydrase VA Lyase P35218
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT143 CA3 Carbonic anhydrase III Lyase P07451
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT151 PRKCA Protein kinase C alpha Kinase P17252
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT158 EPHX2 Epoxide hydratase Lyase P34913
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT195 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 Kinase Q02750
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT207 BACE1 Beta-secretase 1 Protease P56817
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT213 SLC22A1 Solute carrier family 22 member 1 Transporter O15245
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT220 CYP2J2 Cytochrome P450 2J2 Oxidoreductase P51589
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT248 CXCL8 Interleukin-8 Unclassified P10145
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT265 GSK3B Glycogen synthase kinase-3 beta Kinase P49841
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT276 SLCO2B1 Solute carrier organic anion transporter family member 2B1 Transporter O94956
TCMT277 SLCO1B3 Solute carrier organic anion transporter family member 1B3 Transporter Q9NPD5
TCMT278 SLCO1B1 Solute carrier organic anion transporter family member 1B1 Transporter Q9Y6L6
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT281 DPP4 Dipeptidyl peptidase IV Unclassified P27487
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT31 CYP2C19 Cytochrome P450 2C19 Oxidoreductase P33261
TCMT320 MMP3 Matrix metalloproteinase 3 Hydrolase P08254
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT33 CYP3A4 Cytochrome P450 3A4 Oxidoreductase P08684
TCMT331 PLG Plasminogen Unclassified P00747
TCMT336 IDO1 Indoleamine 2,3-dioxygenase Oxidoreductase P14902
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT39 PDE5A Phosphodiesterase 5A Hydrolase O76074
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT402 ALK ALK tyrosine kinase receptor Kinase Q9UM73
TCMT42 KMT2A Histone-lysine N-methyltransferase MLL Transferase Q03164
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT441 PTK2 Focal adhesion kinase 1 Kinase Q05397
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT460 MAPKAPK2 MAP kinase-activated protein kinase 2 Kinase P49137
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT507 MAPK14 MAP kinase p38 alpha Kinase Q16539
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT6 NFKB1 Nuclear factor NF-kappa-B p105 subunit Transcription factor P19838
TCMT601 F2 Thrombin Unclassified P00734
TCMT615 SENP8 Sentrin-specific protease 8 Protease Q96LD8
TCMT629 ABCC1 Multidrug resistance-associated protein 1 Transporter P33527
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT67 PPARG Peroxisome proliferator-activated receptor gamma Nuclear receptor P37231
TCMT69 THRB Thyroid hormone receptor beta-1 Nuclear receptor P10828
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT747 ABCG2 ATP-binding cassette sub-family G member 2 Transporter Q9UNQ0
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT80 MAPK1 MAP kinase ERK2 Kinase P28482
TCMT81 ALOX12 Arachidonate 12-lipoxygenase Oxidoreductase P18054
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT848 ERN1 Serine/threonine-protein kinase/endoribonuclease IRE1 Kinase O75460
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT95 MPG DNA-3-methyladenine glycosylase Hydrolase P29372


Targeted Pathogenic Microbes by the Ingredient of Component

Target ID Target Name
TCMT1090 Human immunodeficiency virus type 1 integrase
TCMT1092 Fatty acid synthase
TCMT1093 Enoyl-acyl-carrier protein reductase
TCMT1094 3-oxoacyl-acyl-carrier protein reductase
TCMT1099 Neuraminidase
TCMT1109 Reverse transcriptase
TCMT1121 Sialidase
TCMT1136 Neuraminidase
TCMT1208 Escherichia coli K12
TCMT1212 Verticillium dahliae
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1246 Escherichia coli
TCMT1286 Bacillus cereus
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1465 Entamoeba histolytica

Ingredient Structrues

Ingredient ID: TCMC817
Formula: C16H22O4

Ingredient ID: TCMC7355
Formula: C8H16O7S

Ingredient ID: TCMC7272
Formula: C29H48O3

Ingredient ID: TCMC6357
Formula: C29H48O3

Ingredient ID: TCMC5716
Formula: C20H36O2

Ingredient ID: TCMC5569
Formula: C27H44O2

Ingredient ID: TCMC449
Formula: C7H5NOS

Ingredient ID: TCMC4400
Formula: C20H38O2

Ingredient ID: TCMC4323
Formula: C29H48O

Ingredient ID: TCMC3806
Formula: C18H32O16

Ingredient ID: TCMC3208
Formula: C15H26O

Ingredient ID: TCMC3088
Formula: C15H30O2

Ingredient ID: TCMC3006
Formula: C17H34O2

Ingredient ID: TCMC2165
Formula: C10H14N2O5

Ingredient ID: TCMC1982
Formula: C15H10O7

Ingredient ID: TCMC1839
Formula: C7H6O3

Ingredient ID: TCMC1766
Formula: C16H13N

Ingredient ID: TCMC1535
Formula: C6H14O6

Ingredient ID: TCMC1031
Formula: C16H22O4

Properties

Ingredient ID Formulae Name MW AlogP MlogP XlogP # HBA # HBD PSA # Rotatable Bond # Ring # Heacy Atom Lipinski RO5 Violation
TCMC449 C7H5NOS 3H-1,3-Benzothiazol-2-One 151.01 0.1303 1.9 1.677 1 1 61.36 1 2 10 0
TCMC817 C16H22O4 Bis(2-Methylpropyl) Benzene-1,2-Dicarboxylate 278.15 0.9868 2.78 4.49 4 0 52.6 12 1 20 0
TCMC1031 C16H22O4 Dibutyl Phthalate 278.15 -1.2084 2.78 5.034 4 0 52.6 12 1 20 1
TCMC1535 C6H14O6 Mannitol 182.08 -2.9402 1.46 -3.896 6 6 121.38 11 0 12 1
TCMC1766 C16H13N N-Phenylnaphthalen-2-Amine 219.1 -0.4204 3.11 6.786 1 1 12.03 2 3 17 1
TCMC1839 C7H6O3 Paraben 138.03 -0.7001 1.9 1.07 2 2 57.53 3 1 10 0
TCMC1982 C15H10O7 Quercetin 302.04 -2.8012 2.34 1.381 2 5 127.45 6 3 22 0
TCMC2165 C10H14N2O5 Thymidine 242.09 -1.7707 1.79 -1 7 3 102.59 6 2 17 0
TCMC3006 C17H34O2 Daturic Acid,Heptadecanoic Acid,Margaric Acid 269.2480553 -4.8635 3.11 7.658 2 0 40.13 15 0 19 2
TCMC3088 C15H30O2 Pentadecanoic Acid 241.2167552 -4.2875 2.89 6.52 2 0 40.13 13 0 17 2
TCMC3208 C15H26O Cedrol,Eudesmol,Α-Cedrol 222.1983655 1.3573 3 5.176 1 1 20.23 0 3 16 1
TCMC3806 C18H32O16 Laminarin 504.1690349 -6.0072 1.68 -5.629 16 11 268.68 7 3 34 2
TCMC4323 C29H48O Fucosterol 412.3705162 2.3613 4.54 10.629 1 1 20.23 5 4 30 1
TCMC4400 C20H38O2 Eicosenoic?Acid 309.2793554 -3.5965 3.44 8.849 2 0 40.13 17 0 22 2
TCMC5569 C27H44O2 24-Keto-Cholesterol 400.3341306 1.5196 4.21 7.809 2 1 37.3 5 4 29 1
TCMC5716 C20H36O2 EicosadienoicAcid 307.2637054 -3.5258 3.44 8.81 2 0 40.13 16 0 22 2
TCMC6357 C29H48O3 24-Hydroperoxy-24-Vinyl-Cholesterol 444.3603454 2.2216 4.32 8.64 3 2 49.69 7 4 32 1
TCMC7272 C29H48O3 29-Hydroperoxy-Stigmasta-5,24(28)-Dien-3Β-Ol 444.3603454 1.8896 4.32 9.009 3 2 49.69 7 4 32 1
TCMC7355 C8H16O7S Fucoidan 255.0538488 -2.0025 1.46 -1.635 7 1 113.5 3 1 16 0

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1. General Information of the Component  
2. TCM Prescriptions with the Component  
3. Putative Targets  
4. Activity & References for Filtering Putative Targets  
5. Ingredient Data & Chemical Structure Information (Properties, InChI, InChIkey, SMILES, etc.)