TCM Prescription: Ji Sheng Ju He Pills



Prescription Description
Prescription IDTCMF4664
Pinyin NameJi Sheng Ju He Wan
Chinese Name济生橘核丸
English NameJi Sheng Ju He Pills
Function Description疝气
IndicationsLower abdominal colic disorder, Hernia
Disease ICD-11 Category SB07 [Lower abdominal colic disorder (TM1), 疝气 (TM1) ];
DD5Z [Hernias, unspecified, 疝，未特指的 ];
Human Tissues Associated with IndicationTestis
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1178 Citrus reticulata 橘核 TCMH1178 ITSAA1245-14
TCMH1742 Cinnamomum cassia 肉桂 TCMH1742 GQ255631
TCMH284 Melia toosendan 川楝子 TCMH284 KY197925
TCMH2073 Prunus persica 桃仁 TCMH2073 ITSAN1047-14
TCMH890 Cortex magnoliae officinalis 厚朴 TCMH890 ITSAM1591-14
TCMH797 Sargassum 海藻 TCMH797
TCMH1226 Laminaria japonica 昆布 TCMH1226 AB022790
TCMH718 Aristolochia manshuriensis 关木通 TCMH718 GBVE2055-11
TCMH2376 Corydalis yanhusuo 延胡索 TCMH2376
TCMH2630 Citrus aurantium 枳实 TCMH2630 ITSAA1279-14
TCMH1533 Saussurea lappa 木香 TCMH1533
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT221 ABCB11 Bile salt export pump Transporter O95342
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT27 DRD1 Dopamine D1 receptor GPCR P21728
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT38 DRD2 Dopamine D2 receptor GPCR P14416
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT561 NT5E 5'-nucleotidase Hydrolase P21589
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT61 MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 Unclassified Q07820
TCMT615 SENP8 Sentrin-specific protease 8 Protease Q96LD8
TCMT616 SENP7 Sentrin-specific protease 7 Protease Q9BQF6
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT636 POLA1 DNA polymerase alpha subunit Transferase P09884
TCMT643 ADRA1A Alpha-1a adrenergic receptor GPCR P35348
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT651 DRD3 Dopamine D3 receptor GPCR P35462
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT853 SIGMAR1 Sigma opioid receptor Unclassified Q99720
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1175 Human immunodeficiency virus
TCMT1178 Actinomyces viscosus
TCMT1183 Candida albicans SC5314
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1243 Aspergillus flavus
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1318 Human T-lymphotropic virus 1
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, ADRA1A, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA12, CA2, CA7, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, F3, FABP3, FABP4, FLT3, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR2B, HTR7, KDR, MCL1, MET, POLA1, POLB, PPARA, SRC, TRPV1, XDH 9.54185
[BP] GO:0042221 response to chemical ADRA1A, AKR1B1, ALOX15, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, FABP3, FABP4, FLT3, HSD17B2, HTR2A, HTR2B, HTR5A, IGF1R, KDR, MCL1, MMP2, MMP9, POLB, PPARA, SRC, TRPV1, TYR 9.45086
[BP] GO:0010033 response to organic substance ADRA1A, AKR1B1, ALOX15, AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, FABP3, FABP4, FLT3, HSD17B2, HTR5A, IGF1R, KDR, MCL1, MMP2, POLB, PPARA, SRC, TRPV1, TYR 9.45086
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, AXL, BCL2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, FABP3, HSD17B2, HTR5A, IGF1R, MMP2, MMP9, POLB, PPARA, SRC, TRPV1, TYR 8.70286
[BP] GO:0007187 None ADORA1, ADRA1A, CHRM2, CNR1, CNR2, DRD1, DRD2, DRD3, HTR1A, HTR5A, HTR6, HTR7 8.70286
[BP] GO:0042493 response to drug ADRA1A, AKR1B1, AXL, BCL2, CA9, CNR1, CNR2, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, FABP3, HTR2A, HTR2B, KDR, POLB, SRC, TRPV1 8.56403
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD2, FABP3, FABP4, FUT7, HSD17B1, HSD17B2, MET, PPARA, TBXAS1, TRPV1 8.50095
[BP] GO:0010647 positive regulation of cell communication ADORA1, ADRA1A, AKR1B1, ALOX15, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F3, FLT3, HTR2A, HTR2B, HTR6, KDR, MCL1, MET, MMP9, PTPN1, SRC, XDH 8.43755
[BP] GO:0023056 positive regulation of signaling ADORA1, ADRA1A, AKR1B1, ALOX15, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F3, FLT3, HTR2A, HTR2B, HTR6, KDR, MCL1, MET, MMP9, PTPN1, SRC, XDH 8.43096
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, DRD1, DRD2, DRD3, HTR2A, HTR2B, KDR, SRC, TRPV1 8.42933
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TYR 8.29961
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, ADRA1A, CA2, CA7, CNR1, CNR2, DRD2 8.04033
[BP] GO:0042592 homeostatic process ADORA1, ADRA1A, AKR1B1, AXL, BCL2, CA12, CA2, CA7, CNR1, DRD1, DRD2, DRD3, FABP3, FABP4, FLT3, HTR2A, HTR2B, MCL1, MET, POLA1, POLB, SRC, TRPV1 7.79681
[BP] GO:0007188 None ADORA1, ADRA1A, CHRM2, CNR1, DRD1, DRD2, DRD3, HTR1A, HTR5A, HTR7 7.21621
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.13742
[BP] GO:0032501 multicellular organismal process ADORA1, ADRA1A, AKR1B1, AKR1B10, ALOX15, ALOX5, AXL, BCL2, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, F3, FABP4, HSD17B2, HTR1A, HTR2A, HTR2B, HTR7, IGF1R, MCL1, MET, MMP1, MMP2, MMP9, PIM1, PPARA, SRC, TRPV1, TYR 7.12255
[BP] GO:0007210 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 7.12255
[BP] GO:0098664 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 7.12255
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA9, CHRM2, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, F3, FABP3, FABP4, FLT3, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, IGF1R, KDR, MCL1, MMP2, MMP9, POLA1, POLB, PPARA, PTPN1, SRC, TRPV1, TYR 7.10297
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, ADRA1A, AKR1B1, ALOX15, AXL, BCL2, CYP1B1, DRD2, F3, FLT3, HTR2A, HTR2B, HTR6, KDR, MCL1, MET, PTPN1, SRC, XDH 7.06906
[BP] GO:0006939 None ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7, TRPV1 6.99788
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX15, ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, FUT7, HTR2B, PIM1, PPARA, TBXAS1, TYR, XDH 6.86897
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CNR1, DRD1, DRD2, DRD3, HTR2A, HTR2B, KDR, SRC, TRPV1 6.82292
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TBXAS1 6.67449
[BP] GO:0009636 response to toxic substance AKR1B1, AXL, BCL2, CNR1, CNR2, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, KDR, POLB, SRC 6.65995
[BP] GO:0032502 developmental process ACHE, ADORA1, ADRA1A, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA9, CBR1, CDC25B, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, FABP4, FLT3, FUT7, HSD17B2, HTR2A, HTR2B, HTR5A, KDR, MCL1, MET, MMP2, MMP9, PIM1, POLB, PPARA, SIGMAR1, SRC, TYR 6.65419
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, ADRA1A, AKR1B1, BCL2, CDC25B, CSNK2A1, CYP1B1, DRD2, DRD3, F3, FABP3, FLT3, HTR1A, HTR2A, HTR2B, IGF1R, KDR, MMP2, MMP9, PIM1, SRC, XDH 6.53695
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, F3, FLT3, HTR2B, IGF1R, KDR, MCL1, MET, MMP9, PIM1, PPARA, PTPN1, SIGMAR1, SRC, TRPV1, XDH 6.51974
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, ADRA1A, AKR1B1, ALOX15, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, F3, FLT3, HTR2A, HTR2B, HTR6, IGF1R, KDR, MCL1, MET, MMP9, PTPN1, SRC, XDH 6.42703
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TBXAS1 6.40932
[BP] GO:0014070 response to organic cyclic compound BCL2, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, DRD3, FLT3, HTR5A, SRC, TRPV1, TYR 6.40463
[BP] GO:0009967 positive regulation of signal transduction ADORA1, ADRA1A, AKR1B1, ALOX15, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, F3, FLT3, HTR2A, HTR2B, HTR6, KDR, MCL1, MET, MMP9, PTPN1, SRC, XDH 6.40463
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, F3, FLT3, HTR2B, IGF1R, KDR, MCL1, MET, MMP9, PIM1, PTPN1, SIGMAR1, SRC, TRPV1, XDH 6.38034
[BP] GO:0050795 None ADORA1, CNR1, DRD2, DRD3, HTR1A, HTR2A, HTR2B 6.24316
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TBXAS1 6.2164
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, ADRA1A, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, KDR, MCL1, MET, MMP9, PTPN1, SRC, XDH 6.2164
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 6.20933
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, ADRA1A, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, F3, FABP3, FLT3, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, KDR, MCL1, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, TRPV1, XDH 6.20316
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, ADRA1A, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, KDR, MCL1, MET, MMP9, PTPN1, SRC, XDH 6.10289
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, DRD2, FABP4, KDR, MMP9, SRC 6.07049
[BP] GO:0097756 None ADORA1, ADRA1A, HTR1A, HTR2A, HTR2B, HTR7 6.02336
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, ADRA1A, CA2, CA7, CNR1, CNR2, DRD1, DRD2, DRD3, HTR2A 5.97131
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, ADRA1A, CA2, CA7, CNR1, CNR2, DRD1, DRD2, DRD3, HTR2A 5.97131
[BP] GO:0007193 None ADORA1, CHRM2, DRD2, DRD3, HTR1A, HTR5A, HTR7 5.79294
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, F3, FLT3, HTR2B, IGF1R, KDR, MCL1, MMP9, PIM1, PTPN1, SIGMAR1, SRC, TRPV1, XDH 5.76453
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, ADRA1A, AKR1B1, ALOX15, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, DRD2, DRD3, F3, FABP4, FLT3, HTR2A, HTR2B, HTR6, KDR, MCL1, MET, MMP2, MMP9, PTPN1, SRC, XDH 5.73891
[BP] GO:0018958 None AKR1B1, BCL2, DRD1, DRD2, DRD3, HTR1A, TYR 5.7314
[BP] GO:0033993 response to lipid AXL, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, FABP3, FLT3, HSD17B2, HTR5A, SRC, TYR 5.64678
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD2, FABP3, FABP4, FUT7, MET, PPARA, TBXAS1 5.64678
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX15, BCL2, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, HTR1A, TYR 5.64111
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, DRD3, FABP3, PPARA, TRPV1 5.6018
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ALOX15, AXL, BCL2, CA2, CA7, CNR1, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F3, HTR1A, HTR2A, HTR2B, IGF1R, KDR, MET, MMP9, PPARA, PTPN1, SRC, TRPV1 5.45677
[BP] GO:0007165 signal transduction ADORA1, ADORA3, ADRA1A, AKR1B1, AXL, BCL2, CA1, CA2, CHRM2, CNR1, CNR2, CSNK2A1, CYP1B1, DRD1, DRD2, DRD3, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MCL1, MET, MMP2, MMP9, PIM1, POLB, PPARA, PTPN1, SIGMAR1, SRC, TRPV1 5.45677
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, AURKB, BCL2, CA2, CYP1A1, DRD1, DRD2, DRD3, HTR2A, HTR2B, MMP2, POLB, PPARA, SRC, TRPV1, TYR 5.43624
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CSNK2A1, DRD2, DRD3, F3, FLT3, HTR1A, HTR2A, HTR2B, IGF1R, KDR, MMP2, MMP9, PIM1 5.37018
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, ADRA1A, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DRD1, DRD2, DRD3, F3, FABP3, FABP4, FLT3, HTR1A, HTR2A, HTR2B, HTR6, IGF1R, KDR, MCL1, MET, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, SRC, TRPV1, XDH 5.19441
[BP] GO:0042310 None ADRA1A, HTR1A, HTR2A, HTR2B, HTR7 5.07019
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TBXAS1 5.07019
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TBXAS1 5.04748
[BP] GO:0003018 None ADORA1, ADRA1A, DRD1, HTR1A, HTR2A, HTR2B, HTR7, SRC 5.04748
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, PPARA, TBXAS1 5.04748
[BP] GO:0048878 chemical homeostasis ADRA1A, AKR1B1, BCL2, CA12, CA2, CA7, CNR1, DRD1, DRD2, DRD3, FABP3, FABP4, HTR2A, HTR2B, MET, TRPV1 5.02705
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, HTR2B, IGF1R, KDR, MCL1, MET, MMP9, PIM1, PPARA, PTPN1, SRC 4.98725
[BP] GO:0001659 None ADORA1, DRD1, DRD2, HTR2A, TRPV1 4.95018
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, CNR2, DRD1, DRD2, HTR2A 4.86783
[BP] GO:0009719 response to endogenous stimulus ADRA1A, AKR1B1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, DRD1, FABP3, FLT3, HTR5A, IGF1R, MMP2, PPARA, SRC, TRPV1 4.80707
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CNR1, CYP19A1, CYP1A1, CYP1B1, DRD2, HSD17B1, HSD17B2, HTR1A, HTR2A 4.78136
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, ADRA1A, CA2, CHRM2, CNR1, CNR2, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, SIGMAR1, SRC 4.71343
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, HTR2B, IGF1R, KDR, MCL1, MET, MMP9, PIM1, PTPN1, SRC 4.71343
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, HSD17B1, HSD17B2 4.67244
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, DRD1, DRD2, HTR2A, MET, TRPV1 4.64345
[BP] GO:0010243 response to organonitrogen compound AKR1B1, CNR1, CNR2, DRD1, DRD2, DRD3, FABP3, FLT3, IGF1R, MMP2, PPARA, SRC, TRPV1, TYR 4.60574
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, CYP2D6, DRD2, DRD3, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC 4.59512
[BP] GO:0007198 None HTR1A, HTR5A, HTR7 4.58503
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.58503
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, CSNK2A1, DRD1, DRD2, DRD3, HTR1A 4.58503
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, HSD17B1, HSD17B2, TBXAS1, TYR, XDH 4.57346
[BP] GO:0097746 None ADORA1, ADRA1A, DRD1, HTR1A, HTR2A, HTR2B, HTR7 4.53081
[BP] GO:0035296 None ADORA1, ADRA1A, DRD1, HTR1A, HTR2A, HTR2B, HTR7 4.53081
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD2, DRD3, FABP3, PPARA, TRPV1 4.51611
[BP] GO:0009725 response to hormone ADRA1A, AKR1B1, BCL2, CA2, CA9, CSNK2A1, CYP1A2, FABP3, FLT3, HTR5A, PPARA, SRC, TRPV1 4.50751
[BP] GO:0051952 None ADORA1, CNR1, DRD1, DRD2, DRD3, HTR2A 4.4969
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, ADRA1A, AKR1B1, ALOX15, AXL, BCL2, CA2, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, FLT3, HSD17B2, HTR5A, KDR, MCL1, MMP9, PIM1, POLB, PPARA, SIGMAR1, SRC, TYR 4.40667
[BP] GO:0050880 None ADORA1, ADRA1A, DRD1, HTR1A, HTR2A, HTR2B, HTR7 4.36705
[BP] GO:0045776 None ADORA1, CNR1, DRD2, DRD3, PPARA 4.36219
[BP] GO:0035150 None ADORA1, ADRA1A, DRD1, HTR1A, HTR2A, HTR2B, HTR7 4.3518
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CNR1, CYP1A1, DRD3, FABP3, FLT3, HTR2A, HTR2B, PPARA, SRC 4.34713
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, SRC 4.32014
[BP] GO:1901698 response to nitrogen compound AKR1B1, CNR1, CNR2, DRD1, DRD2, DRD3, FABP3, FLT3, IGF1R, MMP2, PPARA, SRC, TRPV1, TYR 4.26928
[BP] GO:0003013 None ADORA1, ADRA1A, DRD1, HTR1A, HTR2A, HTR2B, HTR7, SRC 4.25115
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ADRA1A, ALOX15, BCL2, CDC25B, DRD1, DRD2, FABP3, FLT3, HTR2A, HTR2B, KDR, MMP9, PTPN1, SRC, XDH 4.24711
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ADRA1A, ALOX15, BCL2, CDC25B, DRD1, DRD2, FABP3, FLT3, HTR2A, HTR2B, KDR, MMP9, PTPN1, SRC, XDH 4.24711
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ADRA1A, ALOX15, BCL2, CDC25B, DRD1, DRD2, DRD3, FABP3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 4.24592
[BP] GO:0043271 negative regulation of ion transport ADORA1, BCL2, CNR1, DRD2, DRD3, HTR2A, MMP9 4.21298
[BP] GO:0007200 None ADRA1A, CHRM2, DRD1, DRD2, HTR2A, HTR2B 4.203
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ADRA1A, ALOX15, BCL2, CDC25B, DRD1, DRD2, DRD3, FABP3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 4.203
[BP] GO:0032845 None ADORA1, BCL2, DRD2, HTR2A, HTR2B, SRC, TRPV1 4.16059
[BP] GO:2001023 None CNR1, DRD1, DRD2, DRD3, HTR2A, MET 4.15147
[BP] GO:0048148 None DRD1, DRD2, DRD3, HTR2A 4.12194
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, HTR2B, IGF1R, KDR, MCL1, MMP9, PIM1, PTPN1, SRC 4.09997
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, ADRA1A, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, F3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TRPV1, XDH 4.07443
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ADRA1A, ALOX15, DRD2, FLT3, HTR2A, HTR2B, KDR, PTPN1, SRC, XDH 3.96307
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ADRA1A, ALOX15, BCL2, CNR1, CNR2, CYP19A1, DRD1, DRD2, DRD3, IGF1R, MCL1, MET, MMP9, PPARA, PTPN1, SRC, XDH 3.93422
[BP] GO:1902532 negative regulation of intracellular signal transduction ADRA1A, BCL2, DRD2, DRD3, IGF1R, MCL1, MET, MMP9, PTPN1, SRC, XDH 3.92026
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, F3, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HTR1A, HTR2B, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTPN1, SRC, TBXAS1, TRPV1, TYR, XDH 3.91577
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F3, IGF1R, KDR, MET, MMP9, SRC 3.90752
[BP] GO:0048513 animal organ development ACHE, ADRA1A, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, FLT3, HSD17B2, KDR, POLB, PPARA, SRC, TYR 3.87315
[BP] GO:0042325 regulation of phosphorylation ADORA1, ADRA1A, ALOX15, BCL2, CDC25B, DRD1, DRD2, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KDR, MMP9, PPARA, PTPN1, SRC, XDH 3.87315
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3 3.84561
[BP] GO:0048583 regulation of response to stimulus ADORA1, ADRA1A, AKR1B1, ALOX15, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DRD1, DRD2, DRD3, F3, FABP4, FLT3, HTR2A, HTR2B, HTR6, IGF1R, KDR, MCL1, MET, MMP2, MMP9, PPARA, PTPN1, SRC, XDH 3.84561
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ALOX15, AXL, BCL2, CA2, CA7, CNR1, CYP19A1, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, MMP9, PPARA, PTPN1, SRC, TRPV1 3.84554
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, MET, MMP9, SRC 3.83611
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.82993
[BP] GO:0035556 intracellular signal transduction ADRA1A, AKR1B1, AXL, BCL2, CYP1B1, DRD1, DRD2, DRD3, HTR2A, HTR2B, HTR5A, IGF1R, KDR, MCL1, MET, POLB, PTPN1, SRC 3.79497
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ADRA1A, ALOX15, BCL2, CDC25B, DRD1, DRD2, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KDR, MMP9, PTPN1, SRC, XDH 3.72904
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, CNR1, DRD1, DRD2, HTR2A 3.71767
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.71395
[BP] GO:0003008 None ADORA1, ADRA1A, AKR1B1, BCL2, CNR1, CNR2, CYP1B1, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR7, SRC, TRPV1, TYR 3.70712
[BP] GO:0050801 ion homeostasis ADRA1A, BCL2, CA12, CA2, CA7, DRD1, DRD2, DRD3, FABP3, HTR2A, HTR2B, TRPV1 3.70321
[BP] GO:0001975 None CNR2, DRD1, DRD2, DRD3 3.70321
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ADRA1A, ALOX15, BCL2, CDC25B, DRD2, FLT3, HTR2A, HTR2B, KDR, MMP9, PTPN1, SRC, XDH 3.63737
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, ADRA1A, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, DRD1, DRD2, DRD3, F3, FABP4, FLT3, HTR2A, HTR2B, IGF1R, MMP9, PTPN1, SRC, XDH 3.63737
[BP] GO:0051940 None DRD1, DRD2, DRD3 3.61702
[BP] GO:0051584 None DRD1, DRD2, DRD3 3.61702
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, DRD2, PPARA 3.61164
[BP] GO:0014059 None CNR1, DRD2, DRD3, HTR2A 3.58734
[BP] GO:0060402 None ADRA1A, DRD2, HTR2A, HTR2B, TRPV1 3.57395
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, MET, MMP9, SRC 3.57395
[BP] GO:0003012 None ADORA1, ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7, TRPV1 3.54719
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, HSD17B1, HSD17B2 3.52923
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, AXL, BCL2, CA2, CA9, CNR2, CYP1A1, CYP1A2, CYP1B1, DRD1, DRD2, HTR1A, MCL1, MMP2, MMP9, POLA1, POLB, PPARA, PTPN1, SRC, TRPV1 3.50441
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, ADRA1A, BCL2, CNR2, DRD1, DRD2, DRD3, HTR2A, IGF1R, MCL1, MET, MMP9, PTPN1, SRC, XDH 3.49767
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, ADRA1A, BCL2, CNR2, DRD1, DRD2, DRD3, HTR2A, IGF1R, MCL1, MET, MMP9, PTPN1, SRC, XDH 3.48267
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, ADRA1A, CA2, CA7, DRD1, DRD2 3.47498
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, AKR1B10, ALOX15, ALOX5, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, F3, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MCL1, MET, MMP1, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTPN1, SIGMAR1, SRC, TBXAS1, TRPV1, TYR, XDH 3.47497
[BP] GO:0071073 None FABP3, HTR2A, HTR2B 3.47488
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ADRA1A, ALOX15, BCL2, CDC25B, DRD2, FLT3, HTR2A, HTR2B, KDR, MMP9, PTPN1, SRC, XDH 3.45783
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ADRA1A, ALOX15, DRD2, HTR2A, HTR2B, KDR, PTPN1, SRC 3.45217
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, HTR2A, HTR2B, PPARA, SRC 3.44572
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ADRA1A, ALOX15, DRD2, FLT3, HTR2A, HTR2B, IGF1R, KDR, PTPN1, SRC, XDH 3.44304
[BP] GO:0006811 None ADRA1A, CA1, CA12, CA14, CA2, CA4, CA7, CA9, DRD1, DRD2, DRD3, FABP3, HTR2A, HTR2B, PPARA, TRPV1 3.43707
[BP] GO:0032787 None ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, PPARA, TBXAS1 3.42816
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.39947
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, FABP3, FABP4, HTR2A, HTR2B, IGF1R, KDR, MCL1, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TRPV1, XDH 3.38951
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ADRA1A, ALOX15, DRD2, HTR2A, HTR2B, KDR, SRC 3.38951
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, SRC 3.36879
[BP] GO:0007154 None ADORA1, ADRA1A, AXL, BCL2, CHRM2, CNR1, DRD1, DRD2, DRD3, HTR2A, HTR6, HTR7, TRPV1 3.3658
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, DRD2, DRD3, HTR7, PPARA, SRC 3.36285
[BP] GO:0043269 regulation of ion transport ADORA1, BCL2, CA2, CA7, CNR1, DRD1, DRD2, DRD3, HTR1A, HTR2A, MMP9 3.35613
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.35613
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, DRD1, FABP4, FLT3, IGF1R, KDR, MCL1, MMP2, MMP9, POLA1, POLB, PTPN1, SRC, TRPV1 3.30958
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, DRD2, MMP2, POLB, PPARA, SRC 3.29394
[BP] GO:0060401 None ADRA1A, DRD2, HTR2A, HTR2B, TRPV1 3.26821
[BP] GO:0021885 forebrain cell migration AXL, DRD1, DRD2, HTR6 3.25874
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, DRD1, DRD2, F3, IGF1R, KDR, MET, MMP9, SRC 3.24978
[BP] GO:0002031 None DRD2, DRD3, HTR2B 3.23431
[BP] GO:0051896 regulation of protein kinase B signaling AXL, DRD2, DRD3, F3, MET, SRC, XDH 3.22487
[BP] GO:0099536 None CHRM2, CNR1, DRD1, DRD2, DRD3, HTR2A, HTR6, HTR7 3.22487
[BP] GO:0099537 None CHRM2, CNR1, DRD1, DRD2, DRD3, HTR2A, HTR6, HTR7 3.22487
[BP] GO:0051240 positive regulation of multicellular organismal process ADRA1A, AXL, BCL2, CA2, CNR1, CYP1B1, DRD2, DRD3, F3, HTR2A, HTR2B, KDR, MET, MMP9, PIM1, SRC, TRPV1 3.22256
[BP] GO:0042391 None ADORA1, ADRA1A, BCL2, CNR1, CNR2, DRD1, KDR, SRC, TRPV1 3.22256
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HTR1A, HTR2B, IGF1R, KDR, MET, MMP1, MMP2, PIM1, POLA1, POLB, PPARA, PTPN1, SRC, TBXAS1, TYR, XDH 3.22137
[BP] GO:0006936 None ADRA1A, DRD1, DRD2, HTR2A, HTR2B, HTR7, TRPV1 3.19679
[BP] GO:0032467 None AURKB, CDC25B, DRD2, DRD3 3.18571
[BP] GO:0098771 inorganic ion homeostasis ADRA1A, BCL2, CA12, CA2, CA7, DRD1, DRD2, DRD3, HTR2A, HTR2B, TRPV1 3.17051
[BP] GO:0014075 None CNR2, DRD1, DRD2, DRD3 3.1426
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CNR1, CNR2, CYP19A1, DRD1, DRD2, DRD3, F3, FABP4, KDR, MET, PPARA 3.1219
[BP] GO:0019725 cellular homeostasis ADRA1A, BCL2, CA2, CA7, DRD1, DRD2, DRD3, HTR2A, HTR2B, MCL1, POLA1, TRPV1 3.10718
[BP] GO:0008283 cell proliferation ACHE, AURKB, BCL2, CYP1A1, FLT3, HTR1A, MET, PIM1, POLA1, SRC, TYR 3.10482
[BP] GO:0051781 None AURKB, CDC25B, DRD2, DRD3, HTR2B 3.09611
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD1, FLT3, HTR2B, IGF1R, KDR, MET, PIM1, SRC 3.06955
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, CNR1, DRD1, DRD2, DRD3 3.06227
[BP] GO:0010038 response to metal ion ALOX15, BCL2, CA2, CYP1A1, CYP1A2, DRD2, FABP4, MMP9 3.05238
[BP] GO:0008217 None ADORA1, ADRA1A, CNR1, DRD2, DRD3, PPARA 3.04985
[BP] GO:0007610 None BCL2, CNR1, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, PPARA, TRPV1 3.04949
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 3.04861
[BP] GO:0060134 None DRD1, DRD2, DRD3 3.04861
[BP] GO:0032230 positive regulation of synaptic transmission, GABAergic ADRA1A, CA2, CA7 3.04861
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, ALOX15, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, FABP3, FABP4, HTR2A, HTR2B, IGF1R, KDR, MCL1, MET, MMP9, PIM1, PPARA, PTPN1, SRC, TRPV1, XDH 3.04728
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, FLT3, HTR2B, IGF1R, KDR, MET, PIM1, POLB, PTPN1, SRC, XDH 3.03959
[BP] GO:0007568 aging ADRA1A, AURKB, BCL2, CNR1, CYP1A1, HTR2A, POLB 3.01985
[BP] GO:0019932 second-messenger-mediated signaling ADRA1A, DRD1, DRD2, DRD3, HTR2B, HTR5A, KDR 2.97329
[BP] GO:0006584 None AKR1B1, DRD1, DRD2, DRD3 2.96402
[BP] GO:0009712 None AKR1B1, DRD1, DRD2, DRD3 2.96402
[BP] GO:0051580 None DRD1, DRD2, DRD3 2.96054
[BP] GO:0051967 None ADORA1, DRD2, HTR2A 2.96054
[BP] GO:0019933 None ADRA1A, DRD1, DRD2, DRD3, HTR5A 2.96054
[BP] GO:0030003 cellular cation homeostasis ADRA1A, BCL2, CA2, CA7, DRD1, DRD2, DRD3, HTR2A, HTR2B, TRPV1 2.89729
[BP] GO:0051209 None DRD2, HTR2A, HTR2B, TRPV1 2.89729
[BP] GO:0051283 None DRD2, HTR2A, HTR2B, TRPV1 2.89729
[BP] GO:0097366 None CNR2, DRD1, DRD2, DRD3 2.89729
[BP] GO:0016477 cell migration AXL, CNR2, CYP1B1, DRD1, DRD2, FUT7, HTR2B, HTR6, KDR, MMP1, MMP9, SRC 2.8919
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, MCL1, MMP9, PTPN1, SRC 2.88241
[BP] GO:0050961 None ADORA1, HTR2A, TRPV1 2.88241
[BP] GO:0050965 None ADORA1, HTR2A, TRPV1 2.88241
[BP] GO:0001963 None DRD1, DRD2, DRD3 2.88241
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, FABP4, FUT7, MMP1, MMP2, MMP9, SRC, XDH 2.87868
[BP] GO:0003014 None ADORA1, ADRA1A, AKR1B1, BCL2, DRD2 2.8672
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, DRD1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, SRC, TRPV1 2.84207
[BP] GO:0050433 None CNR1, DRD2, DRD3, HTR2A 2.83739
[BP] GO:0006873 cellular ion homeostasis ADRA1A, BCL2, CA2, CA7, DRD1, DRD2, DRD3, HTR2A, HTR2B, TRPV1 2.82422
[BP] GO:2000811 negative regulation of anoikis BCL2, MCL1, SRC 2.80731
[BP] GO:0071071 None FABP3, HTR2A, HTR2B 2.80731
[BP] GO:0032225 None DRD1, DRD2, DRD3 2.80731
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, FLT3, HTR2B, IGF1R, KDR, MET, PIM1, POLB, PTPN1, SRC, XDH 2.80004
[BP] GO:0019935 None ADRA1A, DRD1, DRD2, DRD3, HTR5A 2.79625
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, PIM1, PPARA, TBXAS1, TYR 2.79625
[BP] GO:0009966 regulation of signal transduction ADORA1, ADRA1A, AKR1B1, ALOX15, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DRD2, DRD3, F3, FLT3, HTR2A, HTR2B, HTR6, IGF1R, KDR, MCL1, MET, MMP9, PTPN1, SRC, XDH 2.79625
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, CYP1B1, DRD1, DRD2, DRD3, HTR1A, TRPV1 2.79238
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA1, CA12, CA2, CA7, CA9, CDC25B, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, F3, FABP3, FABP4, FLT3, HSD17B1, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MCL1, MET, MMP1, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTPN1, SIGMAR1, SRC, TRPV1, XDH 2.78412
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, DRD2, MMP2, PPARA, SRC 2.75229
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, MMP9, SRC 2.73926
[BP] GO:0040011 locomotion AXL, CNR2, CYP1B1, DRD1, DRD2, FUT7, HTR2B, HTR6, KDR, MET, MMP1, MMP9, SRC 2.73596
[BP] GO:0051046 None ACHE, ADORA1, CNR1, CYP19A1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, SRC, TRPV1 2.72371
[BP] GO:0009895 negative regulation of catabolic process ADORA1, BCL2, CNR1, HTR2B, MCL1, MET, PPARA 2.71791
[BP] GO:0090066 None ADORA1, ADRA1A, ALOX15, DRD1, HTR1A, HTR2A, HTR2B, HTR7 2.6792
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, DRD2, MMP2, PPARA, SRC 2.6792
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6 2.6745
[BP] GO:0014821 None DRD1, DRD2, HTR2B 2.67267
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ADRA1A, ALOX15, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, F3, FLT3, HTR2A, HTR2B, IGF1R, KDR, MET, MMP9, PPARA, PTPN1, SRC, TRPV1, XDH 2.66459
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.66148
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.66148
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.65948
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ADRA1A, ALOX15, BCL2, CDC25B, DRD2, FLT3, HTR2A, HTR2B, KDR, MMP9, PTPN1, SRC, XDH 2.65171
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, AXL, BCL2, CYP1A1, CYP1B1, DRD1, FABP4, FLT3, IGF1R, KDR, MMP2, SRC, TRPV1 2.62169
[BP] GO:0045187 None ADORA1, DRD2, DRD3 2.61616
[BP] GO:0016048 None ADORA1, HTR2A, TRPV1 2.61616
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.61616
[BP] GO:0031623 None ACHE, DRD2, DRD3, HTR2B 2.61616
[BP] GO:0060160 None DRD2, DRD3 2.61616
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.61616
[BP] GO:0033602 None CNR1, DRD2 2.61616
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.613
[BP] GO:0006874 cellular calcium ion homeostasis ADRA1A, BCL2, DRD1, DRD2, DRD3, HTR2A, HTR2B, TRPV1 2.61042
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, DRD2, DRD3, HTR2B, SRC, TRPV1 2.60487
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PTPN1, SRC 2.60487
[BP] GO:0007267 None ADORA1, ADRA1A, CHRM2, CNR1, DRD1, DRD2, DRD3, HTR2A, HTR6, HTR7 2.60487
[BP] GO:0051282 None DRD1, DRD2, HTR2A, HTR2B, TRPV1 2.59646
[BP] GO:0055080 cation homeostasis ADRA1A, BCL2, CA2, CA7, DRD1, DRD2, DRD3, HTR2A, HTR2B, TRPV1 2.59646
[BP] GO:0032102 negative regulation of response to external stimulus ADORA1, CNR2, CYP19A1, DRD1, DRD2, DRD3, PPARA 2.59646
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.58614
[BP] GO:0097553 None DRD2, HTR2A, HTR2B, TRPV1 2.57639
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA1, CA2, CA7, CA9, CDC25B, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, F3, FABP3, FABP4, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MCL1, MET, MMP1, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTPN1, SIGMAR1, SRC, TRPV1, XDH 2.57639
[BP] GO:0048870 cell motility AXL, CNR2, CYP1B1, DRD1, DRD2, FUT7, HTR2B, HTR6, KDR, MMP1, MMP9, SRC 2.57639
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CYP1B1, DRD1, KDR, SRC, TRPV1 2.57572
[BP] GO:0035813 None ADORA1, DRD2, DRD3 2.57572
[BP] GO:0031399 regulation of protein modification process ADORA1, ADRA1A, ALOX15, BCL2, CDC25B, DRD1, DRD2, FABP4, FLT3, HTR2A, HTR2B, IGF1R, KDR, MMP9, PTPN1, SRC, XDH 2.57337
[BP] GO:0055074 calcium ion homeostasis ADRA1A, BCL2, DRD1, DRD2, DRD3, HTR2A, HTR2B, TRPV1 2.53877
[BP] GO:0042749 None ADORA1, DRD2, DRD3 2.51704
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.51704
[BP] GO:0072503 cellular divalent inorganic cation homeostasis ADRA1A, BCL2, DRD1, DRD2, DRD3, HTR2A, HTR2B, TRPV1 2.50573
[BP] GO:0007268 None CHRM2, DRD1, DRD2, DRD3, HTR2A, HTR6, HTR7 2.49421
[BP] GO:0098916 None CHRM2, DRD1, DRD2, DRD3, HTR2A, HTR6, HTR7 2.49421
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD17B1, HSD17B2 2.48133
[BP] GO:0055082 cellular chemical homeostasis ADRA1A, BCL2, CA2, CA7, DRD1, DRD2, DRD3, HTR2A, HTR2B, TRPV1 2.48133
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ADRA1A, ALOX15, BCL2, CDC25B, CSNK2A1, DRD2, F3, FLT3, HTR2A, HTR2B, KDR, MMP9, PTPN1, SRC, XDH 2.48133
[BP] GO:0043436 oxoacid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, PIM1, PPARA, TBXAS1, TYR 2.45949
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ADRA1A, ALOX15, AURKB, BCL2, CA9, CDC25B, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, F3, FABP3, FABP4, FLT3, HTR1A, HTR2A, HTR2B, IGF1R, KDR, MCL1, MET, MMP9, PIM1, POLA1, PPARA, PTPN1, SRC, TRPV1, XDH 2.45717
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6 2.42086
[BP] GO:0043393 regulation of protein binding AURKB, BCL2, MET, MMP9, PPARA, SRC 2.42086
[BP] GO:0051953 None ADORA1, CNR1, DRD2 2.41601
[BP] GO:2000209 regulation of anoikis BCL2, MCL1, SRC 2.41601
[BP] GO:0044062 None ADORA1, DRD2, DRD3 2.41601
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.41601
[BP] GO:0080134 regulation of response to stress ADORA1, CNR1, CNR2, CYP19A1, DRD2, F3, FABP4, IGF1R, MCL1, MET, MMP2, PPARA, PTPN1, SRC, XDH 2.41601
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, AXL, BCL2, CA2, CYP19A1, DRD1, DRD2, DRD3, HTR2B, SRC, TRPV1 2.40762
[BP] GO:0006082 organic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, PIM1, PPARA, TBXAS1, TYR 2.40032
[BP] GO:0072507 divalent inorganic cation homeostasis ADRA1A, BCL2, DRD1, DRD2, DRD3, HTR2A, HTR2B, TRPV1 2.38101
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ADRA1A, ALOX15, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, F3, FABP3, FLT3, HTR2A, HTR2B, IGF1R, KDR, MET, MMP9, PPARA, PTPN1, SRC, TRPV1, XDH 2.37768
[BP] GO:0038171 None CNR1, CNR2 2.37768
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.37768
[BP] GO:0007202 None ADRA1A, HTR2A, HTR2B 2.37225
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.37225
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, CNR1, CYP19A1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, SRC 2.35044
[BP] GO:0015908 None DRD2, DRD3, FABP3, PPARA 2.34988
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ADRA1A, ALOX15, AURKB, BCL2, CDC25B, DRD1, DRD2, DRD3, F3, FABP3, FLT3, HTR2A, HTR2B, IGF1R, KDR, MET, MMP9, PPARA, PTPN1, SRC, TRPV1, XDH 2.34453
[BP] GO:0032465 None AURKB, CDC25B, DRD2, DRD3 2.32725
[BP] GO:0016310 phosphorylation AURKB, AXL, BCL2, CDC25B, CSNK2A1, DRD1, FLT3, HTR2B, IGF1R, KDR, MET, PIM1, SRC 2.31119
[BP] GO:0023052 None ADORA1, ADRA1A, CHRM2, CNR1, DRD1, DRD2, DRD3, HTR2A, HTR6, HTR7 2.27602
[BP] GO:0010507 negative regulation of autophagy BCL2, HTR2B, MCL1, MET 2.26026
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, AURKB, AXL, BCL2, CNR1, DRD2, DRD3, IGF1R, KDR, MET, MMP1, MMP9, SRC 2.24321
[BP] GO:0007189 None ADRA1A, DRD1, DRD2, DRD3 2.23907
[BP] GO:0030335 positive regulation of cell migration BCL2, DRD1, F3, IGF1R, KDR, MET, MMP9, SRC 2.23433
[BP] GO:0050789 regulation of biological process ACHE, ADORA1, ADORA3, ADRA1A, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA1, CA2, CA7, CA9, CDC25B, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, F3, FABP3, FABP4, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MCL1, MET, MMP1, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTPN1, SIGMAR1, SRC, TRPV1, XDH 2.23131
[BP] GO:0030534 None DRD1, DRD2, DRD3, HTR2A, PPARA 2.22463
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ADRA1A, ALOX15, BCL2, CDC25B, DRD2, F3, FLT3, HTR2A, HTR2B, KDR, MMP9, PTPN1, SRC, XDH 2.22055
[BP] GO:0046320 None CNR1, FABP3, PPARA 2.19264
[BP] GO:0042417 None DRD1, DRD2, DRD3 2.19264
[BP] GO:0051302 None AURKB, CDC25B, DRD2, DRD3, HTR2B 2.19264
[BP] GO:0021853 None DRD1, DRD2 2.19264
[BP] GO:0010641 None F3, SRC 2.19264
[BP] GO:0071502 None HTR2B, TRPV1 2.19264
[BP] GO:1904936 None DRD1, DRD2 2.19264
[BP] GO:0042321 None ADORA1, DRD2 2.19264
[BP] GO:0090325 None DRD2, DRD3 2.19264
[BP] GO:0010513 None HTR2A, HTR2B 2.19264
[BP] GO:0009410 None CNR1, CNR2, DRD1, DRD2, DRD3 2.15495
[BP] GO:2000147 positive regulation of cell motility BCL2, DRD1, F3, IGF1R, KDR, MET, MMP9, SRC 2.14754
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, FLT3, HTR2A, HTR2B, IGF1R, PTPN1, SRC 2.14579
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, FABP4, MMP9 2.13083
[BP] GO:0051098 regulation of binding AURKB, BCL2, CYP2D6, MET, MMP9, PPARA, SRC 2.1258
[BP] GO:0035265 organ growth ADRA1A, BCL2, CYP19A1 2.12016
[BP] GO:0002209 None BCL2, DRD1, HTR1A 2.12016
[BP] GO:0001662 None BCL2, DRD1, HTR1A 2.12016
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, AXL, BCL2, CA1, CSNK2A1, DRD2, F3, FLT3, IGF1R, KDR, MCL1, MET, MMP2, MMP9, PTPN1, SRC, TRPV1 2.10268
[BP] GO:0009605 response to external stimulus ADORA1, ADRA1A, AXL, BCL2, CHRM2, CNR1, CNR2, CYP1A1, CYP1A2, DRD3, HTR2A, SRC, TRPV1, TYR 2.08997
[BP] GO:0042220 None CNR1, DRD2, DRD3 2.08997
[BP] GO:0045777 None ADORA1, ADRA1A, CNR1 2.08997
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling HTR2A, HTR2B, IGF1R 2.08997
[BP] GO:0045744 None DRD2, DRD3, MET 2.08997
[BP] GO:0010039 response to iron ion BCL2, CYP1A1, DRD2 2.08997
[BP] GO:0051272 positive regulation of cellular component movement BCL2, DRD1, F3, IGF1R, KDR, MET, MMP9, SRC 2.08697
[BP] GO:0043065 positive regulation of apoptotic process BCL2, CNR1, CYP1B1, F3, MCL1, MMP9, SRC, TRPV1, XDH 2.0656
[BP] GO:0022029 None DRD1, DRD2, HTR6 2.06298
[BP] GO:0043278 None CNR1, DRD2, DRD3 2.06298
[BP] GO:0014072 None CNR1, DRD2, DRD3 2.06298
[BP] GO:0098801 None ADORA1, DRD2, DRD3 2.06298
[BP] GO:0042596 None BCL2, DRD1, HTR1A 2.06298
[BP] GO:0007204 positive regulation of cytosolic calcium ion concentration ADRA1A, DRD1, DRD2, HTR2A, HTR2B, TRPV1 2.06298
[BP] GO:0034097 response to cytokine ALOX15, AXL, BCL2, FABP4, FLT3, MCL1, SRC, TRPV1 2.06298
[BP] GO:0021843 None DRD1, DRD2 2.06298
[BP] GO:0051902 negative regulation of mitochondrial depolarization BCL2, SRC 2.06298
[BP] GO:0021830 None DRD1, DRD2 2.06298
[BP] GO:0032229 None ADORA1, CNR2 2.06298
[BP] GO:0021826 None DRD1, DRD2 2.06298
[BP] GO:2001300 lipoxin metabolic process ALOX15, ALOX5 2.06298
[BP] GO:0016098 monoterpenoid metabolic process CYP1A2, CYP2D6 2.06298
[BP] GO:0043068 positive regulation of programmed cell death BCL2, CNR1, CYP1B1, F3, MCL1, MMP9, SRC, TRPV1, XDH 2.05281
[BP] GO:2001242 regulation of intrinsic apoptotic signaling pathway BCL2, MCL1, MMP9, PTPN1, SRC 2.04062
[BP] GO:0009894 regulation of catabolic process ADORA1, BCL2, CNR1, CSNK2A1, HTR2A, HTR2B, KDR, MCL1, MET, PPARA, PTPN1 2.03839
[BP] GO:0010863 positive regulation of phospholipase C activity ADRA1A, HTR2A, HTR2B 2.03492
[BP] GO:2001024 negative regulation of response to drug CNR1, DRD2, MET 2.03492
[BP] GO:0006875 cellular metal ion homeostasis ADRA1A, BCL2, DRD1, DRD2, DRD3, HTR2A, HTR2B, TRPV1 2.02657
[BP] GO:0040017 positive regulation of locomotion BCL2, DRD1, F3, IGF1R, KDR, MET, MMP9, SRC 2.0094
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ADRA1A, ALOX15, AURKB, BCL2, CDC25B, CSNK2A1, DRD1, DRD2, DRD3, F3, FLT3, HTR2A, HTR2B, IGF1R, KDR, MET, MMP9, PPARA, PTPN1, SRC, XDH 2.00326
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, ADRA1A, AXL, CA4, CHRM2, CNR1, CNR2, DRD1, DRD2, DRD3, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1, TRPV1 7.98816
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, ADRA1A, AXL, CHRM2, CNR1, CNR2, DRD1, DRD2, DRD3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1, TRPV1 6.89913
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ADRA1A, ALOX15, AXL, CA2, CA4, CA9, CHRM2, CNR1, CNR2, DRD1, DRD2, DRD3, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1, SRC, TRPV1 5.94764
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ADRA1A, ALOX15, ALOX5, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, F3, FLT3, FUT7, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MCL1, MET, MMP2, PIM1, PTPN1, SIGMAR1, SRC, TBXAS1, TRPV1, TYR 5.03248
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ADRA1A, ALOX15, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CHRM2, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, F3, FLT3, FUT7, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MCL1, MET, PTPN1, SIGMAR1, SRC, TBXAS1, TRPV1, TYR 4.84896
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ADRA1A, ALOX15, AXL, CA12, CA14, CA2, CA4, CA9, CHRM2, CNR1, CNR2, CSNK2A1, DRD1, DRD2, DRD3, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, MMP2, PIM1, PTPN1, SRC, TRPV1 4.78525
[CC] GO:0098590 plasma membrane region ADORA1, ADRA1A, CA2, CA4, CA9, CHRM2, CNR1, DRD1, DRD2, HTR2A, MET, SIGMAR1, SRC, TRPV1 3.49953
[CC] GO:0031224 None ACHE, ADORA1, ADORA3, ADRA1A, AXL, CA12, CA14, CA4, CA9, CHRM2, CNR1, CNR2, DRD1, DRD2, DRD3, F3, FLT3, FUT7, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MCL1, MET, SIGMAR1, TBXAS1, TRPV1, TYR 2.74232
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, ADRA1A, AKR1B1, AKR1B10, ALOX15, ALOX5, AURKB, BCL2, CA1, CA2, CA4, CA7, CBR1, CDC25B, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, FABP3, FABP4, FLT3, FUT7, HSD17B1, HSD17B2, HTR2A, HTR5A, KDR, MCL1, MMP2, MMP9, PIM1, POLA1, PTPN1, SIGMAR1, SRC, TBXAS1, TRPV1, TYR, XDH 2.55249
[CC] GO:0031253 None ADORA1, CA4, CA9, DRD1, DRD2, SRC, TRPV1 2.3225
[CC] GO:0042995 cell projection ADORA1, AKR1B1, CA2, CHRM2, CNR1, CNR2, DRD1, DRD2, DRD3, HTR2A, HTR2B, HTR5A, HTR6, SRC 2.13069
[CC] GO:0016021 None ADORA1, ADORA3, ADRA1A, AXL, CA12, CA14, CA9, CHRM2, CNR1, CNR2, DRD1, DRD2, DRD3, F3, FLT3, FUT7, HSD17B2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MCL1, MET, SIGMAR1, TBXAS1, TRPV1, TYR 2.10588
[CC] GO:0044463 None ADORA1, AKR1B1, CA4, CA9, CHRM2, CNR1, DRD1, DRD2, HTR2A, SIGMAR1, SRC, TRPV1 2.08997
[CC] GO:0120038 None ADORA1, AKR1B1, CA4, CA9, CHRM2, CNR1, DRD1, DRD2, HTR2A, SIGMAR1, SRC, TRPV1 2.08997
[CC] GO:0097443 sorting endosome KDR, PTPN1 2.06298
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.54185
[MF] GO:0008227 None ADRA1A, CHRM2, DRD2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 9.09803
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, MMP1, MMP2, MMP9, PIM1, PPARA, PTPN1, TBXAS1, TYR, XDH 8.56403
[MF] GO:0070405 ammonium ion binding ACHE, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR5A, HTR7 8.43755
[MF] GO:0030594 None CHRM2, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 8.43755
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, ADRA1A, AXL, CHRM2, CNR1, CNR2, DRD1, DRD2, DRD3, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PPARA, SIGMAR1, TRPV1 8.43096
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, ADRA1A, AXL, CHRM2, CNR1, CNR2, DRD1, DRD2, DRD3, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1, TRPV1 8.42933
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, ADRA1A, AXL, CHRM2, CNR1, CNR2, DRD1, DRD2, DRD3, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, SIGMAR1, TRPV1 8.42933
[MF] GO:0043167 ion binding ACHE, ALOX15, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, F3, FABP3, FABP4, FLT3, HSD17B1, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTPN1, SRC, TBXAS1, TRPV1, TYR, XDH 8.39417
[MF] GO:0099528 None CHRM2, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 7.5365
[MF] GO:0004872 receptor activity ADORA1, ADORA3, ADRA1A, AXL, CHRM2, CNR1, CNR2, DRD1, DRD2, DRD3, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PPARA, SIGMAR1, TRPV1 7.5365
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CHRM2, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, FLT3, HTR2A, HTR2B, IGF1R, KDR, MET, PIM1, PPARA, SIGMAR1, SRC, TRPV1 7.42295
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, ADRA1A, AXL, CHRM2, CNR1, CNR2, DRD1, DRD2, DRD3, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PPARA, SIGMAR1, TRPV1 7.28306
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9, POLB 7.12255
[MF] GO:0004993 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 7.12255
[MF] GO:0099589 None HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7 7.12255
[MF] GO:0043176 None HTR1A, HTR2A, HTR2B, HTR5A, HTR7 7.08701
[MF] GO:0051378 None HTR1A, HTR2A, HTR2B, HTR5A, HTR7 7.08701
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, ADRA1A, AXL, CHRM2, CNR1, CNR2, DRD1, DRD2, DRD3, F3, FLT3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, IGF1R, KDR, MET, PPARA, SIGMAR1, TRPV1 6.87953
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.6445
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR5A, HTR7, MMP1, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTPN1, TBXAS1, TRPV1, TYR, XDH 6.34515
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TBXAS1, XDH 6.08763
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, F3, FLT3, FUT7, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIM1, POLA1, POLB, PTPN1, SRC, TBXAS1, TYR, XDH 5.68933
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, HSD17B1, HSD17B2, TBXAS1, TYR, XDH 5.6018
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 5.55558
[MF] GO:0004930 None ADORA1, ADORA3, ADRA1A, CHRM2, CNR1, CNR2, DRD1, DRD2, DRD3, HTR1A, HTR2A, HTR2B, HTR5A, HTR6, HTR7, SIGMAR1 5.45677
[MF] GO:0042165 neurotransmitter binding ACHE, HTR1A, HTR2A, HTR2B, HTR5A, HTR7 5.35899
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 5.30459
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TBXAS1, TYR 5.2109
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9, POLB 4.55628
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, SRC, TBXAS1 4.45118
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, SRC, TBXAS1 4.25646
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 4.24244
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TBXAS1, TYR 3.96307
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.62854
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, HSD17B1, POLA1, SRC, TBXAS1, XDH 3.39947
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, CBR1, HSD17B1, HSD17B2, XDH 3.23431
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 3.20886
[MF] GO:0004952 None DRD1, DRD2, DRD3 3.13569
[MF] GO:0035240 None DRD1, DRD2, DRD3 3.04861
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.66068
[MF] GO:0004949 None CNR1, CNR2 2.61616
[MF] GO:1901338 None DRD1, DRD2, DRD3 2.57572
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HSD17B1, HSD17B2 2.50906
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, MMP1, MMP2, MMP9, PPARA, PTPN1 2.40974
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, CSNK2A1, FLT3, HTR2A, IGF1R, KDR, MMP9, PIM1, PPARA, PTPN1, SRC 2.3225
[MF] GO:0051434 BH3 domain binding BCL2, MCL1 2.19264
[MF] GO:0005158 None IGF1R, PTPN1, SRC 2.08997
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, MMP1, MMP2, MMP9, PIM1, POLA1, POLB, PPARA, PTPN1, TBXAS1, TRPV1, TYR, XDH 2.08697
[MF] GO:0004064 arylesterase activity CA1, CA2 2.06298
[MF] GO:0008395 steroid hydroxylase activity CYP19A1, CYP1A1, CYP2D6 2.00017


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2, HTR2B, HTR1A, TRPV1, HTR2A, HTR5A, ADRA1A, HTR6, HTR7, CNR2, CNR1, ADORA3, ADORA1, DRD1, DRD2, DRD3 13.4972
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.5669
Serotonergic synapse_Homo sapiens_hsa04726 HTR6, HTR7, CYP2D6, ALOX5, ALOX15, HTR2B, HTR1A, HTR2A, HTR5A 8.5035
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, CYP19A1, IGF1R 8.1925
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2, HTR6, HTR7, HTR2B, HTR2A, DRD1, HTR5A, ADRA1A 5.6899
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 6.1461
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HTR6, ADORA1, HTR1A, DRD1, DRD2, PPARA 4.2812
Metabolic pathways_Homo sapiens_hsa01100 CBR1, ALOX15, AKR1B1, TYR, CYP19A1, POLA1, FUT7, AKR1B10, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, XDH 4.1761
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 CBR1, CYP2D6, CYP1A2, CYP1A1, CYP1B1 4.2812
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.2812
Gap junction_Homo sapiens_hsa04540 SRC, HTR2B, HTR2A, DRD1, DRD2 4.0349
Proteoglycans in cancer_Homo sapiens_hsa05205 SRC, MMP2, KDR, MMP9, MET, IGF1R 3.4206
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.0349
MicroRNAs in cancer_Homo sapiens_hsa05206 BCL2, PIM1, CYP1B1, MMP9, MET, CDC25B, MCL1 3.4206
Rap1 signaling pathway_Homo sapiens_hsa04015 SRC, CNR1, KDR, DRD2, MET, IGF1R 3.3636
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, TBXAS1 3.4206
Pathways in cancer_Homo sapiens_hsa05200 FLT3, MMP1, MMP2, BCL2, MMP9, MET, IGF1R 2.7951
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 SRC, HTR2B, TRPV1, HTR2A 2.7924
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 MMP2, BCL2, PIM1, F3 2.7815
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.2917
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, KDR, BCL2, MET, MCL1, IGF1R 2.4324
Focal adhesion_Homo sapiens_hsa04510 SRC, KDR, BCL2, MET, IGF1R 2.6223
Chemical carcinogenesis_Homo sapiens_hsa05204 CBR1, CYP1A2, CYP1A1, CYP1B1 3.0473
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 1.9161
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, CYP1B1 2.7924
Estrogen signaling pathway_Homo sapiens_hsa04915 SRC, MMP2, MMP9 1.769
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, BCL2 1.6728
Ras signaling pathway_Homo sapiens_hsa04014 HTR7, KDR, MET, IGF1R 1.6552
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.4965
Dopaminergic synapse_Homo sapiens_hsa04728 DRD1, DRD2, DRD3 1.5439
Sphingolipid signaling pathway_Homo sapiens_hsa04071 ADORA3, BCL2, ADORA1 1.618
Hepatitis B_Homo sapiens_hsa05161 SRC, BCL2, MMP9 1.4326
Jak-STAT signaling pathway_Homo sapiens_hsa04630 BCL2, PIM1, MCL1 1.3622
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 ADORA3, ADORA1, ADRA1A 1.3356
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, ADORA1 1.3622
Acute myeloid leukemia_Homo sapiens_hsa05221 FLT3, PIM1 1.3616
Prostate cancer_Homo sapiens_hsa05215 BCL2, IGF1R 1.0924
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 0.9454
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.0911
VEGF signaling pathway_Homo sapiens_hsa04370 SRC, KDR 1.3356
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 CDC25B, IGF1R 1.0482
Central carbon metabolism in cancer_Homo sapiens_hsa05230 FLT3, MET 1.2776
Melanoma_Homo sapiens_hsa05218 MET, IGF1R 1.2572
Morphine addiction_Homo sapiens_hsa05032 ADORA1, DRD1 1.0911
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PPARA 0.9801
HIF-1 signaling pathway_Homo sapiens_hsa04066 BCL2, IGF1R 1.0168
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.3433
Platelet activation_Homo sapiens_hsa04611 SRC, TBXAS1 0.9219
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.2747
Apoptosis_Homo sapiens_hsa04210 BCL2, MCL1 0.838
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 SRC, MET 1.1897
Cocaine addiction_Homo sapiens_hsa05030 DRD1, DRD2 1.4437
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2 1.0818
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1 1.293
Toxoplasmosis_Homo sapiens_hsa05145 ALOX5, BCL2 0.9404
Leukocyte transendothelial migration_Homo sapiens_hsa04670 MMP2, MMP9 0.9404
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2D6, CYP1A2 1.2717
AMPK signaling pathway_Homo sapiens_hsa04152 ADRA1A, IGF1R 0.9165
Parkinson's disease_Homo sapiens_hsa05012 DRD1, DRD2 0.8339
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 0.838
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 BCL2, ADRA1A 0.8159
Purine metabolism_Homo sapiens_hsa00230 POLA1, XDH 0.7249
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, BCL2 0.6457
Alcoholism_Homo sapiens_hsa05034 DRD1, DRD2 0.7249
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.7249
Viral carcinogenesis_Homo sapiens_hsa05203 POLB, SRC 0.6457
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, SRC 0.6267
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 1.769
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.7565
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.2524
HTLV-I infection_Homo sapiens_hsa05166 POLB 0.2524
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3428
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.369
Chemokine signaling pathway_Homo sapiens_hsa04062 SRC 0.3428
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PPARA 0.3998
Oxytocin signaling pathway_Homo sapiens_hsa04921 SRC 0.3879
Measles_Homo sapiens_hsa05162 CSNK2A1 0.4217
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 IGF1R 0.4173
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1 0.4176
FoxO signaling pathway_Homo sapiens_hsa04068 IGF1R 0.4259
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.4173
Neurotrophin signaling pathway_Homo sapiens_hsa04722 BCL2 0.4438
Hepatitis C_Homo sapiens_hsa05160 PPARA 0.4259
TNF signaling pathway_Homo sapiens_hsa04668 MMP9 0.4637
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4396
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7153
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 SRC 0.4438
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.4396
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6552
Axon guidance_Homo sapiens_hsa04360 MET 0.4347
Vascular smooth muscle contraction_Homo sapiens_hsa04270 ADRA1A 0.4438
Melanogenesis_Homo sapiens_hsa04916 TYR 0.4872
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.4872
ErbB signaling pathway_Homo sapiens_hsa04012 SRC 0.5058
Taste transduction_Homo sapiens_hsa04742 HTR1A 0.5063
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 IGF1R 0.494
Pyrimidine metabolism_Homo sapiens_hsa00240 POLA1 0.4769
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.494
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 CNR1 0.4872
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.494
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5058
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5058
Small cell lung cancer_Homo sapiens_hsa05222 BCL2 0.5058
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5058
Salivary secretion_Homo sapiens_hsa04970 ADRA1A 0.5058
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5058
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 1.9234
Peroxisome_Homo sapiens_hsa04146 XDH 0.5063
Prolactin signaling pathway_Homo sapiens_hsa04917 SRC 0.5426
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.5367
Complement and coagulation cascades_Homo sapiens_hsa04610 F3 0.5161
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5441
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 IGF1R 0.5585
Glioma_Homo sapiens_hsa05214 IGF1R 0.5585
Renal cell carcinoma_Homo sapiens_hsa05211 MET 0.5574
Bile secretion_Homo sapiens_hsa04976 CA2 0.5433
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.5645
Amphetamine addiction_Homo sapiens_hsa05031 DRD1 0.5564
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.5585
Colorectal cancer_Homo sapiens_hsa05210 BCL2 0.5585
Shigellosis_Homo sapiens_hsa05131 SRC 0.5585
Malaria_Homo sapiens_hsa05144 MET 0.6293
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.624
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6457
Tyrosine metabolism_Homo sapiens_hsa00350 TYR 0.7249
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7582
DNA replication_Homo sapiens_hsa03030 POLA1 0.7249
Base excision repair_Homo sapiens_hsa03410 POLB 0.7385
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8159
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.8094
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.1509


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)