TCM Prescription: He Luo Shu Gan Capsules



Prescription Description
Prescription IDTCMF4319
Pinyin NameHe Luo Shu Gan Jiao Nang
Chinese Name和络舒肝胶囊
English NameHe Luo Shu Gan Capsules
Function Description胁痛
IndicationsHypochondrium pain disorder
Disease ICD-11 Category SA00 [Hypochondrium pain disorder (TM1), 胁痛 (TM1) ];
Human Tissues Associated with IndicationHeart, Lung
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH120 Atractylodes macrocephala 白术 TCMH120 ITSAN4430-14
TCMH104 Paeonia lactiflora 白芍 TCMH104 ITSAH2416-14
TCMH1766 Sparganium stoloniferum 三棱 TCMH1766 ITSAJ4240-14
TCMH2265 Cyperus rotundus 香附 TCMH2265 GENG1049-15
TCMH544 Curcuma aeruginosa 莪术 TCMH544 ITSAN2146-14
TCMH1518 Chaenomeles sinensis 木瓜 TCMH1518 GBVJ2053-11, GBVJ2052-11
TCMH363 Rheum officinale 大黄 TCMH363 ITSAJ4685-14
TCMH865 Carthamus tinctorius 红花 TCMH865 ITSAI2447-14
TCMH178 Carapax trionycis 鳖甲 TCMH178
TCMH2073 Prunus persica 桃仁 TCMH2073 ITSAN1047-14
TCMH2532 Curcuma aromatica 郁金 TCMH2532 ITSAF2298-14
TCMH2494 Artemisia capillaris 茵陈蒿 TCMH2494 ITSAN1371-14
TCMH797 Sargassum 海藻 TCMH797
TCMH1226 Laminaria japonica 昆布 TCMH1226 AB022790
TCMH2343 Scrophularia ningpoensis 玄参 TCMH2343 ITSAO4295-14
TCMH451 Rehmannia glutinosa 地黄 TCMH451 ITSAH4578-14
TCMH1966 Rehmannia glutinosa 熟地黄 TCMH1966 ITSAH4578-14
TCMH921 Polygonum cuspidatum 虎杖 TCMH921 ITSAI2369-14
TCMH2129 Eupolyphaga sinensis 土鳖虫 TCMH2129 GBMIN33972-13
TCMH228 Bupleurum chinense 柴胡 TCMH228 ITSAM2218-14
TCMH819 Polygonum multiflorum 何首乌 TCMH819 ITSAL419-14
TCMH1293 Campsis grandiflora 凌霄花 TCMH1293 GBVK2075-11, GBVK2076-11
TCMH1666 catharsii molosii 蜣螂 TCMH1666
TCMH2188 Trogopterus xanthipes 五灵脂 TCMH2188
TCMH834 Semen glycine max 黑豆 TCMH834 ITSAJ4675-14
TCMH122 Lobelia chinensis 半边莲 TCMH122 ITSAL4535-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT100 TTR Transthyretin Unclassified P02766
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT114 CNR2 Cannabinoid CB2 receptor GPCR P34972
TCMT115 CNR1 Cannabinoid CB1 receptor GPCR P21554
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT13 APEX1 DNA-(apurinic or apyrimidinic site) lyase Lyase P27695
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT132 BCHE Butyrylcholinesterase Hydrolase P06276
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT151 PRKCA Protein kinase C alpha Kinase P17252
TCMT152 PRKCB Protein kinase C beta Kinase P05771
TCMT153 PRKCG Protein kinase C gamma Kinase P05129
TCMT154 PRKCD Protein kinase C delta Kinase Q05655
TCMT155 PRKCE Protein kinase C epsilon Kinase Q02156
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT160 HTR7 Serotonin 7 (5-HT7) receptor GPCR P34969
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT167 AKR1C3 Aldo-keto-reductase family 1 member C3 Oxidoreductase P42330
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT187 AR Androgen Receptor Nuclear receptor P10275
TCMT189 DUSP3 Dual specificity protein phosphatase 3 Hydrolase P51452
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT193 RELA Nuclear factor NF-kappa-B p65 subunit Transcription factor Q04206
TCMT194 MAP3K7 Mitogen-activated protein kinase kinase kinase 7 Kinase O43318
TCMT195 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 Kinase Q02750
TCMT196 MAP2K7 Dual specificity mitogen-activated protein kinase kinase 7 Kinase O14733
TCMT2 MAPT Microtubule-associated protein tau Unclassified P10636
TCMT208 MAOA Monoamine oxidase A Oxidoreductase P21397
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT213 SLC22A1 Solute carrier family 22 member 1 Transporter O15245
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT230 HSD17B3 Estradiol 17-beta-dehydrogenase 3 Oxidoreductase P37058
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT301 PTGES Prostaglandin E synthase Isomerase O14684
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT309 SLC22A2 Solute carrier family 22 member 2 Transporter O15244
TCMT310 SLC47A2 Multidrug and toxin extrusion protein 2 Transporter Q86VL8
TCMT311 SLC47A1 Multidrug and toxin extrusion protein 1 Transporter Q96FL8
TCMT313 HTR2B Serotonin 2b (5-HT2b) receptor GPCR P41595
TCMT314 HTR2C Serotonin 2c (5-HT2c) receptor GPCR P28335
TCMT315 HTR6 Serotonin 6 (5-HT6) receptor GPCR P50406
TCMT318 HKDC1 Putative hexokinase HKDC1 Transferase Q2TB90
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT327 TRPV1 Vanilloid receptor Ion channel Q8NER1
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT354 AURKA Serine/threonine-protein kinase Aurora-A Kinase O14965
TCMT36 HTR1A Serotonin 1a (5-HT1a) receptor GPCR P08908
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT37 HTR2A Serotonin 2a (5-HT2a) receptor GPCR P28223
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT377 INSR Insulin receptor Kinase P06213
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT418 EPHB4 Ephrin type-B receptor 4 Kinase P54760
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT423 EGFR Epidermal growth factor receptor erbB1 Kinase P00533
TCMT436 NUAK1 NUAK family SNF1-like kinase 1 Kinase O60285
TCMT44 GLO1 Glyoxalase I Lyase Q04760
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT45 APP Beta amyloid A4 protein Unclassified P05067
TCMT457 FLT4 Vascular endothelial growth factor receptor 3 Kinase P35916
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT502 TEK Tyrosine-protein kinase TIE-2 Kinase Q02763
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT510 KIT Stem cell growth factor receptor Kinase P10721
TCMT536 PDGFRB Platelet-derived growth factor receptor beta Kinase P09619
TCMT558 TOP2A DNA topoisomerase II alpha Isomerase P11388
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT565 EP300 Histone acetyltransferase p300 Transferase Q09472
TCMT566 NOS2 Nitric oxide synthase, inducible Oxidoreductase P35228
TCMT570 ANPEP Aminopeptidase N Unclassified P15144
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT598 TOP1 DNA topoisomerase I Isomerase P11387
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT608 SLC22A3 Solute carrier family 22 member 3 Transporter O75751
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT626 BRAF Serine/threonine-protein kinase B-raf Kinase P15056
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT645 HTR1E Serotonin 1e (5-HT1e) receptor GPCR P28566
TCMT646 HTR5A Serotonin 5a (5-HT5a) receptor GPCR P47898
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT690 HDAC3 Histone deacetylase 3 Hydrolase O15379
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT721 HSPA1A Heat shock 70 kDa protein 1 Unclassified P0DMV8
TCMT725 CACNA1C Voltage-gated L-type calcium channel alpha-1C subunit Ion channel Q13936
TCMT726 BCR Bcr/Abl fusion protein Kinase P11274
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT734 MMP12 Matrix metalloproteinase 12 Hydrolase P39900
TCMT737 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G Unclassified Q9HC16
TCMT739 GPR35 G-protein coupled receptor 35 GPCR Q9HC97
TCMT740 PIK3CG PI3-kinase p110-gamma subunit Transferase P48736
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT753 SMAD3 Mothers against decapentaplegic homolog 3 Unclassified P84022
TCMT755 PLK4 Serine/threonine-protein kinase PLK4 Kinase O00444
TCMT756 MAP3K8 Mitogen-activated protein kinase kinase kinase 8 Kinase P41279
TCMT759 SAE1 SUMO-activating enzyme subunit 1 Unclassified Q9UBE0
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT80 MAPK1 MAP kinase ERK2 Kinase P28482
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT815 HTR1D Serotonin 1d (5-HT1d) receptor GPCR P28221
TCMT816 HTR1B Serotonin 1b (5-HT1b) receptor GPCR P28222
TCMT817 HTR4 Serotonin 4 (5-HT4) receptor GPCR Q13639
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT83 CD38 Lymphocyte differentiation antigen CD38 Unclassified P28907
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT99 SHBG Testis-specific androgen-binding protein Unclassified P04278


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1180 Human herpesvirus 2
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1183 Candida albicans SC5314
TCMT1189 Pseudomonas fluorescens
TCMT1190 Plasmodium falciparum (isolate FcB1 / Columbia)
TCMT1201 Staphylococcus epidermidis ATCC 12228
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1218 Staphylococcus aureus
TCMT1219 Enterococcus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1231 Human herpesvirus 1 strain KOS
TCMT1232 Pseudomonas aeruginosa
TCMT1243 Aspergillus flavus
TCMT1245 Phytophthora cactorum
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1257 Colletotrichum lagenarium
TCMT1282 Colletotrichum orbiculare
TCMT1284 Penicillium expansum
TCMT1285 Human coxsackievirus B3
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1313 Human immunodeficiency virus 2
TCMT1314 Streptococcus viridans
TCMT1321 Staphylococcus hominis
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1408 Colletotrichum gloeosporioides
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0065008 regulation of biological quality ACHE, ADORA1, AKR1B1, AKR1C3, ALOX15, APEX1, APP, AR, AURKB, AXL, BCHE, BCL2, CA12, CA2, CA7, CACNA1C, CNR1, CNR2, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, GPR35, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HSPA1A, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR4, HTR7, INSR, KDR, KIT, MAOA, MET, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PTGS1, PTGS2, SLC22A1, SLC22A2, SLC22A3, SMAD3, SRC, TEK, TRPV1, XDH 19.6579
[BP] GO:0042221 response to chemical AKR1B1, AKR1C3, ALOX15, ALPL, APEX1, APP, AR, AXL, BCHE, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HSPA1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, IGF1R, INSR, KDR, KIT, MMP2, MMP9, PIK3CA, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS2, RELA, RORC, SMAD3, SRC, TEK, TOP1, TRPV1, TYR 17.8723
[BP] GO:0010033 response to organic substance AKR1B1, AKR1C3, ALOX15, ALPL, APEX1, APP, AR, AXL, BCHE, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HSPA1A, HTR1B, HTR5A, IGF1R, INSR, KDR, KIT, MMP2, PIK3CA, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS2, RELA, RORC, SMAD3, SRC, TEK, TRPV1, TYR 17.0012
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AR, AXL, BCL2, CYP1B1, EGFR, F10, F3, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCE, PTGS2, PTPN1, RELA, SRC, TEK, XDH 16.5504
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, AKR1C3, ALPL, APEX1, APP, AR, AXL, BCHE, BCL2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP3, HSD11B2, HSD17B2, HTR1B, HTR5A, IGF1R, INSR, MMP2, MMP9, PIK3CA, PPARA, PRKCB, PRKCD, PRKCE, PTGES, PTGS2, RELA, RORC, SRC, TEK, TRPV1, TYR 16.5144
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, F3, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, RELA, SMAD3, SRC, TEK, XDH 16.2281
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AR, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, F3, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, RELA, SMAD3, SRC, TEK, XDH 16.2232
[BP] GO:0007210 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 15.6302
[BP] GO:0098664 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 15.6302
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AR, AXL, BCL2, CSNK2A1, CYP1B1, EGFR, F10, F3, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, RELA, SMAD3, SRC, TEK, XDH 15.283
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, F10, F3, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, RELA, SRC, TEK, XDH 14.9836
[BP] GO:0014070 response to organic cyclic compound AKR1C3, ALPL, APEX1, APP, AR, BCHE, BCL2, CA2, CA9, CNR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FLT3, HSD11B2, HTR1B, HTR5A, PRKCE, PRKCG, PTGES, PTGS2, RELA, RORC, SRC, TEK, TRPV1, TYR 14.9526
[BP] GO:0009725 response to hormone AKR1B1, AKR1C3, ALPL, APEX1, AR, BCHE, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, HSD11B2, HTR1B, HTR5A, INSR, KIT, PPARA, PRKCD, PRKCE, PTGS2, RELA, SRC, TEK, TRPV1 14.0277
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AKR1C3, APEX1, AR, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, HSPA1A, HTR2B, IGF1R, KDR, KIT, MAP2K1, MET, MMP9, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, RELA, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 13.5683
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, AKR1C3, APP, AR, BCHE, BCL2, CDC25B, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FABP3, FLT3, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, IGF1R, INSR, KDR, KIT, MAP2K1, MMP12, MMP2, MMP9, NUAK1, PIM1, PRKCA, PTGES, PTGS1, PTGS2, RELA, SMAD3, SRC, TEK, XDH 13.3723
[BP] GO:0050896 response to stimulus ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, ALOX15, ALPL, APEX1, APP, AR, AURKB, AXL, BCHE, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, HSPA1A, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, RELA, RORC, SMAD3, SRC, TEK, TOP1, TOP2A, TRPV1, TYR 13.3723
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AKR1C3, APEX1, AR, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, HSPA1A, HTR2B, IGF1R, KDR, KIT, MAP2K1, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, RELA, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 13.3723
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BCHE, BCL2, CA2, CA7, CACNA1C, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, F10, F3, FLT3, GPR35, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, RELA, SMAD3, SRC, TEK, XDH 13.3723
[BP] GO:0009719 response to endogenous stimulus AKR1B1, AKR1C3, ALPL, APEX1, APP, AR, BCHE, BCL2, CA2, CA9, CSNK2A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, HSD11B2, HTR1B, HTR5A, IGF1R, INSR, KIT, MMP2, PPARA, PRKCD, PRKCE, PTGS2, RELA, SMAD3, SRC, TEK, TRPV1 13.3288
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BCHE, BCL2, CA2, CA7, CACNA1C, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, F10, F3, FLT3, GPR35, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, RELA, SMAD3, SRC, TEK, XDH 13.1959
[BP] GO:0033993 response to lipid AKR1C3, ALPL, AR, AXL, BCHE, BCL2, CA2, CA9, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, EGFR, ESR1, FABP3, FLT3, HSD11B2, HSD17B2, HTR1B, HTR5A, PRKCE, PTGES, PTGS2, RELA, RORC, SRC, TYR 13.1959
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AR, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, F10, F3, FABP4, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RELA, SMAD3, SRC, TEK, XDH 13.0741
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, APP, AR, AXL, BCHE, BCL2, CACNA1C, CNR1, CNR2, CYP19A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, F10, F3, FABP4, HSD11B2, HSD17B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR7, IGF1R, INSR, KIT, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIM1, PPARA, PRKCD, PRKCG, PTGS2, RELA, RORC, SMAD3, SRC, TEK, TOP1, TRPV1, TYR 12.2796
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AKR1C3, APEX1, AR, AURKB, AXL, BCL2, CNR1, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GLO1, HSPA1A, HTR2B, IGF1R, KDR, MAP2K1, MMP9, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, RELA, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 12.2198
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, APP, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP3, FABP4, FUT7, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, KIT, MET, PIK3CA, PIK3CB, PPARA, PTGES, PTGS1, PTGS2, TRPV1 11.7879
[BP] GO:0032879 regulation of localization ACHE, ADORA1, ADORA3, ALOX15, APEX1, APP, AR, AXL, BCL2, CA2, CA7, CACNA1C, CNR1, CSNK2A1, CYP19A1, CYP1B1, EGFR, F10, F3, GPR35, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAP2K1, MET, MMP12, MMP9, PIK3CB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TEK, TRPV1 11.523
[BP] GO:0042493 response to drug AKR1B1, APEX1, AXL, BCHE, BCL2, CA9, CNR1, CNR2, CYP1A1, CYP1B1, EGFR, FABP3, HSD11B2, HTR1B, HTR2A, HTR2B, HTR2C, KDR, PRKCD, PRKCE, PRKCG, PTGS2, RELA, SRC, TOP1, TRPV1 11.1901
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, AKR1C3, ALOX15, APEX1, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, F10, F3, FABP3, FLT3, GPR35, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RELA, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 11.0243
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, AKR1C3, CACNA1C, CNR1, CYP19A1, CYP1A1, CYP1B1, EGFR, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HTR1A, HTR2A, HTR2C, PRKCA, PRKCE, SLC22A1 10.7973
[BP] GO:0010035 response to inorganic substance AKR1B1, AKR1C3, ALOX15, APEX1, APP, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP4, KDR, KIT, MMP9, PRKCD, PTGES, PTGS2, RELA, SRC 10.6145
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HSPA1A, HTR2B, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIM1, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, RELA, SMAD3, SRC, TEK 10.4308
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HSPA1A, HTR2B, IGF1R, KDR, KIT, MET, MMP9, PIK3CA, PIM1, PPARA, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, RELA, SMAD3, SRC, TEK 10.3616
[BP] GO:0071310 cellular response to organic substance AKR1B1, AKR1C3, ALOX15, ALPL, APEX1, APP, AR, AXL, BCL2, CYP1A1, CYP1B1, EGFR, ESR1, FABP4, FLT3, HTR1B, IGF1R, INSR, KDR, KIT, MMP2, PIK3CA, PRKCB, PRKCD, PRKCE, PTGS2, RELA, RORC, SMAD3, SRC, TRPV1 10.1682
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, AKR1C3, ALOX15, ALPL, APEX1, APP, AR, AXL, BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, HSPA1A, HTR1B, IGF1R, INSR, KDR, KIT, MMP2, MMP9, PIK3CA, PRKCB, PRKCD, PRKCE, PTGS2, RELA, RORC, SMAD3, SRC, TRPV1 10.1682
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, APP, AR, EGFR, FLT3, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MAP2K1, MAP3K7, PIK3CB, PRKCA, PRKCE, PTPN1, SRC, TEK, XDH 9.83188
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, DUSP3, EGFR, FABP3, FABP4, FLT3, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 9.7361
[BP] GO:0006468 protein phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, EGFR, FLT3, HTR2B, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP1 9.72899
[BP] GO:0043408 regulation of MAPK cascade ADORA1, ALOX15, APP, AR, DUSP3, EGFR, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, PIK3CB, PRKCA, PRKCD, PRKCE, PTPN1, SRC, TEK, XDH 9.7131
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, EGFR, FABP3, FLT3, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 9.7131
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, EGFR, FABP3, FLT3, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 9.7131
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, DUSP3, EGFR, FABP3, FABP4, FLT3, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 9.67498
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, APP, AR, BCL2, CDC25B, EGFR, FLT3, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 9.66879
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SRC, TEK, TOP1, XDH 9.66576
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, AKR1C3, AR, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, F3, FLT3, HTR1A, HTR1B, HTR2A, HTR2B, IGF1R, INSR, KDR, KIT, MMP12, MMP2, MMP9, PIM1, PRKCA, PTGS2, RELA, TEK 9.51543
[BP] GO:1903727 positive regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, KIT, PRKCD, SRC, TEK 9.3425
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, APP, AR, BCL2, CDC25B, EGFR, FLT3, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 9.26753
[BP] GO:0010243 response to organonitrogen compound AKR1B1, APEX1, APP, BCHE, CNR1, CNR2, EGFR, FABP3, FLT3, HSD11B2, HTR1B, IGF1R, INSR, MMP2, PPARA, PRKCD, PRKCE, PRKCG, PTGS2, RELA, SRC, TEK, TRPV1, TYR 9.25651
[BP] GO:0048518 positive regulation of biological process ACHE, ADORA1, AKR1B1, AKR1C3, ALOX15, APEX1, APP, AR, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, GPR35, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RELA, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 9.20363
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, APEX1, APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, FLT3, HSPA1A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SRC, TEK, TOP1, XDH 9.11322
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, KIT, PPARA, PRKCD, PRKCE, PTGS2, SRC, TEK 9.06096
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AR, AURKB, AXL, BCL2, CSNK2A1, EGFR, GLO1, HSPA1A, HTR2B, IGF1R, KDR, MMP9, PIK3CA, PIM1, PRKCA, PRKCD, PRKCG, PTGS2, PTPN1, RELA, SMAD3, SRC, TEK 9.05254
[BP] GO:0048583 regulation of response to stimulus ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, F10, F3, FABP4, FLT3, GPR35, HSPA1A, HTR1B, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RELA, SMAD3, SRC, TEK, XDH 8.9668
[BP] GO:1901698 response to nitrogen compound AKR1B1, APEX1, APP, BCHE, CNR1, CNR2, EGFR, FABP3, FLT3, HSD11B2, HTR1B, IGF1R, INSR, MMP2, PPARA, PRKCD, PRKCE, PRKCG, PTGS2, RELA, SRC, TEK, TRPV1, TYR 8.60158
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, AKR1C3, ALOX15, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, F10, F3, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, HTR6, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, RELA, SMAD3, SRC, TEK, XDH 8.59173
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, F3, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, RELA, SMAD3, SRC, TEK, XDH 8.58661
[BP] GO:0016310 phosphorylation APP, AURKB, AXL, BCL2, CDC25B, CSNK2A1, EGFR, FLT3, HTR2B, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP1 8.5834
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, AKR1C3, CNR1, CYP1A1, FABP3, FLT3, HTR2A, HTR2B, HTR2C, KIT, PPARA, PRKCD, PRKCE, PTGS2, RORC, SRC, TEK 8.56002
[BP] GO:0019369 arachidonic acid metabolic process AKR1C3, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGES, PTGS1, PTGS2 8.48888
[BP] GO:0051716 cellular response to stimulus AKR1B1, AKR1C3, ALOX15, ALPL, APEX1, APP, AR, AURKB, AXL, BCL2, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FABP4, FLT3, HSPA1A, HTR1B, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MMP2, MMP9, NUAK1, PIK3CA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, RELA, RORC, SMAD3, SRC, TOP2A, TRPV1 8.43388
[BP] GO:0051049 regulation of transport ACHE, ADORA1, ALOX15, APP, AXL, BCL2, CA2, CA7, CACNA1C, CNR1, CYP19A1, EGFR, GPR35, HSPA1A, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, INSR, MAP2K1, MMP12, MMP9, PIK3CB, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, SMAD3, SRC, TRPV1 8.3827
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, APEX1, APP, AR, AURKB, AXL, BCHE, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HSPA1A, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, RELA, RORC, SLC22A2, SMAD3, SRC, TEK, TOP1, TOP2A, TRPV1, TYR, XDH 8.37467
[BP] GO:0048513 animal organ development ACHE, AKR1C3, AR, AXL, BCL2, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, EGFR, ESR1, FLT3, HSD11B1, HSD17B2, HSD17B3, INSR, KDR, KIT, MAP2K1, PIK3CA, PPARA, RELA, SMAD3, SRC, TEK, TYR 8.32435
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, AKR1C3, ALOX15, ALPL, APEX1, APP, AR, AURKB, AXL, BCHE, BCL2, CA2, CA9, CACNA1C, CBR1, CDC25B, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD17B2, HSD17B3, HTR2A, HTR2B, HTR5A, INSR, KDR, KIT, MAP2K1, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCD, PTGS2, RELA, RORC, SMAD3, SRC, TEK, TOP2A, TYR 8.31629
[BP] GO:0031399 regulation of protein modification process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RELA, SRC, TEK, XDH 8.29982
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ALOX15, APP, AR, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 8.27408
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, AKR1C3, APP, AR, AXL, BCL2, CA1, CA2, CACNA1C, CNR1, CNR2, CSNK2A1, CYP1B1, EGFR, ESR1, F3, FLT3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTPN1, RELA, RORC, SMAD3, SRC, TEK, TRPV1 8.23685
[BP] GO:0097756 None ADORA1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 8.15715
[BP] GO:0051897 positive regulation of protein kinase B signaling AKR1C3, AXL, EGFR, F10, F3, INSR, KIT, MET, PIK3CA, PIK3CB, SRC, TEK 8.09277
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, APP, AR, BCL2, CDC25B, DUSP3, EGFR, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 8.07961
[BP] GO:0006950 response to stress ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, ALOX15, APEX1, APP, AXL, BCL2, CA2, CA9, CNR2, CYP1A1, CYP1A2, CYP1B1, EGFR, HSD11B2, HSPA1A, HTR1A, HTR2C, KIT, MAP2K1, MAP3K7, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, RELA, SMAD3, SRC, TEK, TOP2A, TRPV1 8.07961
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, APEX1, APP, AR, AURKB, AXL, BCHE, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, FABP3, FABP4, GLO1, GPR35, HSPA1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MET, MMP12, MMP9, PIK3CA, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS2, PTPN1, RELA, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 7.95736
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, EGFR, ESR1, F3, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 7.90421
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, AKR1C3, APP, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 7.86163
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AKR1C3, APEX1, APP, AR, AXL, CYP1B1, EGFR, ESR1, IGF1R, INSR, MMP2, MMP9, PIK3CA, PRKCB, PRKCD, PRKCE, PTGS2, RELA, RORC, SRC, TRPV1 7.79366
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, APEX1, APP, AXL, BCL2, CA12, CA2, CA7, CACNA1C, CNR1, EGFR, ESR1, FABP3, FABP4, FLT3, GPR35, HTR2A, HTR2B, HTR2C, INSR, MET, PIK3CA, PIK3CB, PRKCB, PRKCE, SMAD3, SRC, TRPV1 7.75006
[BP] GO:0009628 response to abiotic stimulus ADORA1, AKR1B1, APP, AURKB, BCL2, CA2, CYP1A1, EGFR, HSD11B2, HSPA1A, HTR1B, HTR2A, HTR2B, KIT, MMP2, PPARA, PRKCB, PRKCE, PTGS2, RELA, SMAD3, SRC, TEK, TRPV1, TYR 7.72459
[BP] GO:0080134 regulation of response to stress ADORA1, APP, CNR1, CNR2, CYP19A1, DUSP3, EGFR, ESR1, F3, FABP4, HSPA1A, IGF1R, MAP2K1, MAP3K7, MET, MMP12, MMP2, NUAK1, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RELA, SMAD3, SRC, TEK, XDH 7.72144
[BP] GO:0051896 regulation of protein kinase B signaling AKR1C3, AXL, EGFR, F10, F3, INSR, KIT, MET, PIK3CA, PIK3CB, SRC, TEK, XDH 7.63721
[BP] GO:0033559 unsaturated fatty acid metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGES, PTGS1, PTGS2 7.63721
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, APEX1, APP, BCL2, CYP19A1, CYP1B1, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK 7.62128
[BP] GO:0048878 chemical homeostasis AKR1B1, APP, BCL2, CA12, CA2, CA7, CACNA1C, CNR1, EGFR, ESR1, FABP3, FABP4, GPR35, HTR2A, HTR2B, HTR2C, INSR, MET, PIK3CA, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 7.51238
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, EGFR, FLT3, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MAP2K1, MAP3K7, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC, TEK, XDH 7.50849
[BP] GO:1903725 regulation of phospholipid metabolic process FABP3, FLT3, HTR2A, HTR2B, HTR2C, KIT, PRKCD, SRC, TEK 7.47256
[BP] GO:0048545 response to steroid hormone AKR1C3, ALPL, AR, BCHE, BCL2, CA2, EGFR, FLT3, HSD11B2, HTR1B, PTGS2, RELA, SRC 7.46433
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, APP, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FUT7, GLO1, HSD17B3, HSPA1A, HTR2B, HTR2C, PIK3CA, PIM1, PPARA, PTGES, PTGS1, PTGS2, TYR, XDH 7.41198
[BP] GO:0030335 positive regulation of cell migration APP, BCL2, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK 7.39512
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, EGFR, F10, FLT3, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP1, TOP2A 7.38698
[BP] GO:0006690 icosanoid metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGES, PTGS1, PTGS2 7.37276
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, AKR1C3, BCL2, CYP1A1, CYP1A2, CYP1B1, TYR 7.28293
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, APEX1, APP, BCL2, CYP19A1, CYP1B1, EGFR, F10, F3, HTR1D, IGF1R, INSR, KDR, KIT, MET, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK 7.2771
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, APEX1, APP, BCL2, CACNA1C, CYP19A1, CYP1B1, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK 7.25327
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, APP, AR, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KIT, MAP2K1, MAP3K7, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC, TEK, XDH 7.25327
[BP] GO:0032228 regulation of synaptic transmission, GABAergic ADORA1, CA2, CA7, CNR1, CNR2, HTR1B, PRKCE 7.24042
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AKR1C3, APEX1, AXL, CYP1B1, EGFR, MMP9, PRKCD, RELA, SRC 7.23461
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 7.2343
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MAP2K1, MET, PRKCD, SRC, TEK 7.21467
[BP] GO:2000147 positive regulation of cell motility APP, BCL2, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK 7.20827
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, AKR1C3, ALOX15, APP, AR, AURKB, BCL2, CDC25B, EGFR, ESR1, F3, FABP3, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RELA, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 7.20827
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, APEX1, APP, BCL2, CYP19A1, CYP1B1, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK 7.18115
[BP] GO:0043405 regulation of MAP kinase activity ADORA1, DUSP3, EGFR, FLT3, HTR2A, HTR2B, IGF1R, INSR, KIT, MAP2K1, MAP3K7, PIK3CB, PRKCD, PTPN1, SRC 7.16884
[BP] GO:0018212 peptidyl-tyrosine modification AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MAP2K1, MET, PRKCD, SRC, TEK 7.15527
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ALOX15, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, F3, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RELA, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 7.15527
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, APEX1, AXL, BCL2, CNR1, CNR2, CYP1A1, CYP1B1, HTR1B, HTR1D, KDR, PRKCD, PRKCE, RELA, SRC 7.12975
[BP] GO:0006979 response to oxidative stress AKR1B1, AKR1C3, APEX1, APP, AXL, BCL2, CYP1B1, EGFR, HSPA1A, MMP9, PRKCD, PTGS1, PTGS2, RELA, SRC 7.12907
[BP] GO:0009894 regulation of catabolic process ADORA1, APEX1, BCL2, CNR1, CSNK2A1, EGFR, HSPA1A, HTR2A, HTR2B, INSR, KDR, MAP3K7, MET, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTPN1, RELA, SMAD3 7.1137
[BP] GO:0051272 positive regulation of cellular component movement APP, BCL2, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK 7.05504
[BP] GO:0071495 cellular response to endogenous stimulus AKR1B1, AKR1C3, APEX1, APP, AR, EGFR, ESR1, FLT3, HTR1B, IGF1R, INSR, KIT, MMP2, PRKCD, PRKCE, PTGS2, RELA, SMAD3, SRC, TRPV1 7.04735
[BP] GO:0065009 regulation of molecular function ADORA1, ADORA3, APP, AR, AURKB, BCL2, CDC25B, CNR1, CNR2, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, GPR35, HSPA1A, HTR2A, HTR2B, IGF1R, INSR, KIT, MAP2K1, MAP3K7, MET, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, RELA, SMAD3, SRC, TEK, TRPV1, XDH 7.01216
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CACNA1C, CNR1, EGFR, HTR2A, HTR2B, HTR2C, KDR, PIK3CB, PRKCE, PTGS2, SRC, TRPV1 7.01216
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, APEX1, APP, AR, AURKB, AXL, BCHE, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HSD17B1, HSD17B2, HSD17B3, HSPA1A, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP2, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, RELA, RORC, SLC22A2, SMAD3, SRC, TEK, TOP1, TOP2A, TYR, XDH 7.01216
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, KIT, PIM1, PRKCG, SRC, TEK 7.00734
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, ALOX15, APEX1, APP, AR, AURKB, AXL, BCHE, BCL2, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1B1, DUSP3, EGFR, ESR1, FABP3, FABP4, GLO1, GPR35, HSPA1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, KDR, KIT, MAP2K1, MET, MMP12, MMP9, PIK3CA, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS2, PTPN1, RELA, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 7.00645
[BP] GO:0003018 None ADORA1, EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2, SRC, TEK 6.963
[BP] GO:0007198 None HTR1A, HTR1B, HTR5A, HTR7 6.9301
[BP] GO:0050804 modulation of chemical synaptic transmission ACHE, ADORA1, APP, BCHE, CA2, CA7, CNR1, CNR2, EGFR, HTR1B, HTR2A, KIT, PRKCE, PTGS2 6.91474
[BP] GO:0099177 regulation of trans-synaptic signaling ACHE, ADORA1, APP, BCHE, CA2, CA7, CNR1, CNR2, EGFR, HTR1B, HTR2A, KIT, PRKCE, PTGS2 6.91474
[BP] GO:0040017 positive regulation of locomotion APP, BCL2, EGFR, F10, F3, IGF1R, INSR, KDR, KIT, MET, MMP9, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TEK 6.85989
[BP] GO:0009893 positive regulation of metabolic process ADORA1, AKR1C3, ALOX15, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, F3, FABP3, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RELA, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 6.76573
[BP] GO:0042446 hormone biosynthetic process AKR1B1, AKR1C3, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 6.74988
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, CACNA1C, HTR2A, HTR2B, HTR2C, KDR, PRKCE, SRC, TRPV1 6.7411
[BP] GO:0051240 positive regulation of multicellular organismal process APP, AR, AXL, BCL2, CA2, CNR1, CYP1B1, EGFR, F3, HSPA1A, HTR2A, HTR2B, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIM1, PRKCA, PRKCB, PRKCE, PTGS2, RELA, SMAD3, SRC, TEK, TRPV1 6.71309
[BP] GO:0019371 None AKR1C3, CBR1, PTGES, PTGS1, PTGS2 6.59125
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, MAOA, NQO2, PTGS1, PTGS2, TYR, XDH 6.58214
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AKR1C3, APEX1, AXL, BCL2, CYP1B1, EGFR, MMP9, PRKCD, RELA, SRC 6.4694
[BP] GO:0070372 regulation of ERK1 and ERK2 cascade ALOX15, APP, DUSP3, EGFR, HTR2A, HTR2B, HTR2C, KDR, MAP2K1, PRKCA, PTPN1, SRC, TEK 6.43018
[BP] GO:0001676 long-chain fatty acid metabolic process AKR1C3, ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGES, PTGS1, PTGS2 6.34413
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.33551
[BP] GO:0035690 cellular response to drug AKR1B1, APEX1, AXL, CYP1B1, EGFR, HTR1B, KDR, PRKCD, PRKCE, PTGS2, RELA, SRC, TRPV1 6.29008
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, EGFR, ESR1, HTR7, KIT, PPARA, PRKCG, RORC, SRC, TOP1, TOP2A 6.25739
[BP] GO:0007187 None ADORA1, CNR1, CNR2, HTR1A, HTR1B, HTR1D, HTR1E, HTR4, HTR5A, HTR6, HTR7 6.25739
[BP] GO:0007610 None APP, BCHE, BCL2, CNR1, EGFR, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, INSR, KIT, PPARA, PRKCE, PRKCG, PTGS2, TRPV1 6.24477
[BP] GO:0065007 biological regulation ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, ALOX15, APEX1, APP, AR, AURKB, AXL, BCHE, BCL2, CA1, CA12, CA2, CA7, CA9, CACNA1C, CDC25B, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, GLO1, GPR35, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, RELA, RORC, SLC22A1, SLC22A2, SLC22A3, SMAD3, SRC, TEK, TOP1, TOP2A, TRPV1, XDH 6.21075
[BP] GO:1901652 response to peptide AKR1B1, APEX1, APP, FABP3, HSD11B2, IGF1R, INSR, PPARA, PRKCD, PTGS2, RELA, SRC, TEK, TRPV1 6.14549
[BP] GO:0035556 intracellular signal transduction AKR1B1, AXL, BCL2, CACNA1C, CYP1B1, EGFR, HTR2A, HTR2B, HTR5A, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RELA, SRC, TEK 6.14306
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ALOX15, APP, AR, AURKB, BCL2, CDC25B, CSNK2A1, EGFR, ESR1, F3, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RELA, RORC, SMAD3, SRC, TEK, TOP2A, XDH 6.12745
[BP] GO:0071407 cellular response to organic cyclic compound AKR1C3, ALPL, APEX1, APP, AR, CYP1A1, CYP1B1, EGFR, ESR1, FLT3, PTGS2, RORC, SRC, TRPV1 6.12584
[BP] GO:0044093 positive regulation of molecular function ADORA1, APP, AR, AURKB, BCL2, CDC25B, EGFR, ESR1, F3, FLT3, HSPA1A, HTR2A, HTR2B, INSR, KIT, MAP2K1, MAP3K7, MET, MMP9, PIK3CA, PIK3CB, PRKCB, PRKCD, PRKCE, PTPN1, RELA, SMAD3, SRC, TEK, XDH 6.12584
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CNR1, CNR2, CYP19A1, EGFR, ESR1, F3, FABP4, KDR, MAP2K1, MET, MMP12, PPARA, PRKCA, PRKCD, PRKCG, PTGS2, RELA, SMAD3, TEK 6.12513
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, AKR1C3, ALOX15, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, PIK3CA, PIK3CB, PTGES, PTGS1, PTGS2 6.1137
[BP] GO:0031347 regulation of defense response ADORA1, CNR1, CNR2, CYP19A1, EGFR, ESR1, FABP4, HSPA1A, MAP3K7, MMP12, MMP2, PPARA, PRKCD, PRKCE, PTGS2, PTPN1, RELA, SMAD3, SRC, TEK 6.09278
[BP] GO:0032268 regulation of cellular protein metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RELA, SMAD3, SRC, TEK, XDH 6.0917
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, AKR1C3, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2, HSD17B3 6.0917
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, AKR1C3, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FABP3, FABP4, FUT7, KIT, MET, PIK3CA, PIK3CB, PPARA, PTGES, PTGS1, PTGS2 6.05212
[BP] GO:0034599 cellular response to oxidative stress AKR1B1, AKR1C3, APEX1, AXL, CYP1B1, EGFR, HSPA1A, MMP9, PRKCD, RELA, SRC 6.03178
[BP] GO:0030168 platelet activation AXL, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC 6.02847
[BP] GO:0042310 None HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7 5.97743
[BP] GO:0070374 positive regulation of ERK1 and ERK2 cascade ALOX15, APP, EGFR, HTR2A, HTR2B, HTR2C, KDR, MAP2K1, PRKCA, SRC, TEK 5.97401
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PTPN1, SRC, TEK 5.93411
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, APP, AR, AXL, BCL2, CA2, CACNA1C, CNR1, CYP1B1, EGFR, ESR1, F3, GPR35, HSPA1A, HTR2A, HTR2B, HTR2C, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, RELA, SMAD3, SRC, TEK, TRPV1, XDH 5.91376
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, APP, AR, AURKB, AXL, BCHE, BCL2, CDC25B, CSNK2A1, CYP1A1, CYP1A2, DUSP3, EGFR, ESR1, F10, F3, FLT3, FUT7, GLO1, HSPA1A, HTR1A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RELA, SMAD3, SRC, TEK, TOP1, TOP2A, TYR, XDH 5.89631
[BP] GO:0031960 response to corticosteroid AKR1C3, ALPL, BCHE, BCL2, EGFR, FLT3, HSD11B2, HTR1B, PTGS2, SRC 5.89631
[BP] GO:1901568 fatty acid derivative metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGES, PTGS1, PTGS2 5.89631
[BP] GO:0008283 cell proliferation ACHE, AR, AURKB, BCL2, CYP1A1, EGFR, ESR1, FLT3, HTR1A, KIT, MAP2K1, MET, PIK3CB, PIM1, PRKCD, SRC, TEK, TYR 5.86933
[BP] GO:0001505 regulation of neurotransmitter levels ACHE, BCHE, CYP1B1, EGFR, HTR1A, INSR, MAOA, PTGS2, SLC22A2, SLC22A3, SMAD3, TRPV1 5.85043
[BP] GO:0003013 None ADORA1, EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2, SRC, TEK 5.81728
[BP] GO:0010648 negative regulation of cell communication ACHE, ADORA1, AR, BCHE, BCL2, CNR2, DUSP3, EGFR, ESR1, GPR35, HSPA1A, HTR1B, HTR2A, IGF1R, MET, MMP12, MMP9, PRKCB, PRKCD, PTGS2, PTPN1, RELA, SMAD3, SRC, XDH 5.81728
[BP] GO:0003008 None ADORA1, AKR1B1, AKR1C3, APP, BCHE, BCL2, CNR1, CNR2, CYP1B1, EGFR, HSD11B2, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, INSR, KIT, PIK3CA, PRKCG, PTGS2, SRC, TEK, TRPV1, TYR 5.80288
[BP] GO:0023057 negative regulation of signaling ACHE, ADORA1, AR, BCHE, BCL2, CNR2, DUSP3, EGFR, ESR1, GPR35, HSPA1A, HTR1B, HTR2A, IGF1R, MET, MMP12, MMP9, PRKCB, PRKCD, PTGS2, PTPN1, RELA, SMAD3, SRC, XDH 5.79485
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PRKCB, PRKCE, PTGS2, SMAD3, SRC, TEK 5.78611
[BP] GO:0010038 response to metal ion AKR1C3, ALOX15, APP, BCL2, CA2, CYP1A1, CYP1A2, EGFR, FABP4, KIT, MMP9, PTGES, PTGS2 5.74283
[BP] GO:0050801 ion homeostasis APP, BCL2, CA12, CA2, CA7, CACNA1C, EGFR, ESR1, FABP3, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 5.73983
[BP] GO:0043406 positive regulation of MAP kinase activity ADORA1, EGFR, FLT3, HTR2A, HTR2B, INSR, KIT, MAP2K1, MAP3K7, PIK3CB, PTPN1, SRC 5.70938
[BP] GO:0001101 response to acid chemical AKR1B1, AKR1C3, BCHE, EGFR, FABP3, HSD17B2, KDR, MMP2, PRKCE, PTGES, PTGS2, RELA, SRC 5.70938
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MAP3K7, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PTPN1, SMAD3, SRC, TEK 5.70283
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PRKCB, PRKCE, PTGS2, SMAD3, SRC, TEK 5.66257
[BP] GO:0097746 None ADORA1, EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 5.63996
[BP] GO:0035296 None ADORA1, EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 5.63996
[BP] GO:0043549 regulation of kinase activity ADORA1, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, HTR2A, HTR2B, IGF1R, INSR, KIT, MAP2K1, MAP3K7, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC, TEK 5.6294
[BP] GO:0048608 reproductive structure development AKR1C3, AR, AXL, BCL2, CYP19A1, ESR1, HSD17B2, HSD17B3, INSR, KIT, MAP2K1, SRC 5.61897
[BP] GO:2000377 regulation of reactive oxygen species metabolic process AKR1C3, BCL2, CYP1B1, EGFR, INSR, PRKCD, PTGS2, SMAD3, TRPV1, XDH 5.58954
[BP] GO:2000379 positive regulation of reactive oxygen species metabolic process AKR1C3, EGFR, INSR, PRKCD, PTGS2, SMAD3, TRPV1, XDH 5.54303
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, APEX1, APP, AR, AURKB, AXL, BCHE, BCL2, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HSPA1A, HTR1A, HTR1B, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, RELA, RORC, SMAD3, SRC, TEK, TOP1, TOP2A, TRPV1, TYR, XDH 5.54079
[BP] GO:0001775 cell activation ALOX5, APP, AXL, BCL2, EGFR, FLT3, FUT7, HSPA1A, KIT, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, RORC, SMAD3, SRC, TRPV1 5.46212
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.4543
[BP] GO:0033674 positive regulation of kinase activity ADORA1, CDC25B, EGFR, FLT3, HTR2A, HTR2B, INSR, KIT, MAP2K1, MAP3K7, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC, TEK 5.43821
[BP] GO:0045859 regulation of protein kinase activity ADORA1, APP, CDC25B, DUSP3, EGFR, FABP4, FLT3, HTR2A, HTR2B, IGF1R, INSR, KIT, MAP2K1, MAP3K7, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC 5.42266
[BP] GO:0050880 None ADORA1, EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 5.42266
[BP] GO:0035150 None ADORA1, EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PTGS2 5.39608
[BP] GO:0050805 negative regulation of synaptic transmission ACHE, ADORA1, BCHE, CNR2, HTR1B, HTR2A, PTGS2 5.3089
[BP] GO:0050795 None ADORA1, CNR1, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B 5.3089
[BP] GO:0072507 divalent inorganic cation homeostasis APP, BCL2, CACNA1C, EGFR, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 5.29271
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PRKCB, PRKCE, PTGS2, SMAD3, SRC, TEK 5.28819
[BP] GO:0098771 inorganic ion homeostasis APP, BCL2, CA12, CA2, CA7, CACNA1C, EGFR, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 5.27468
[BP] GO:0006631 fatty acid metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, PPARA, PTGES, PTGS1, PTGS2 5.21105
[BP] GO:0007186 G-protein coupled receptor signaling pathway ADORA1, ADORA3, AKR1C3, APP, CA2, CNR1, CNR2, ESR1, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, INSR, PIK3CA, PIK3CB, SRC 5.20417
[BP] GO:0043271 negative regulation of ion transport ADORA1, BCL2, CNR1, GPR35, HTR1B, HTR2A, MMP9, PRKCE, PTGS2 5.19312
[BP] GO:0048732 gland development AR, BCL2, CSNK2A1, CYP19A1, EGFR, INSR, MAP2K1, PIK3CA, RELA, SMAD3, TYR 5.15521
[BP] GO:0071900 regulation of protein serine/threonine kinase activity ADORA1, DUSP3, EGFR, FLT3, HTR2A, HTR2B, IGF1R, INSR, KIT, MAP2K1, MAP3K7, PIK3CB, PRKCD, PTPN1, SRC 5.14122
[BP] GO:0009991 response to extracellular stimulus AKR1C3, ALPL, AXL, BCHE, BCL2, CNR1, CYP1A1, EGFR, HSD11B2, PTGS2, RELA, SRC, TRPV1, TYR 5.13457
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, AKR1C3, ALOX15, ALPL, APP, AR, AXL, BCL2, CA2, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, FLT3, HSD11B1, HSD17B2, HSD17B3, HTR5A, INSR, KDR, KIT, MAP2K1, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RELA, RORC, SMAD3, SRC, TEK, TYR 5.09187
[BP] GO:0007584 response to nutrient AKR1C3, ALPL, BCHE, CNR1, CYP1A1, EGFR, PTGS2, RELA, TRPV1, TYR 5.0876
[BP] GO:0051338 regulation of transferase activity ADORA1, APP, AURKB, CDC25B, DUSP3, EGFR, FABP4, FLT3, HTR2A, HTR2B, IGF1R, INSR, KIT, MAP2K1, MAP3K7, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC, TEK 5.08405
[BP] GO:0071073 None FABP3, HTR2A, HTR2B, HTR2C 5.06059
[BP] GO:0051246 regulation of protein metabolic process ADORA1, ALOX15, APP, AR, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MMP9, NUAK1, PIK3CA, PIK3CB, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RELA, SMAD3, SRC, TEK, XDH 5.05445
[BP] GO:0043085 positive regulation of catalytic activity ADORA1, APP, AURKB, BCL2, CDC25B, EGFR, ESR1, F3, FLT3, HSPA1A, HTR2A, HTR2B, INSR, KIT, MAP2K1, MAP3K7, PIK3CA, PIK3CB, PRKCD, PRKCE, PTPN1, SMAD3, SRC, TEK, XDH 5.04584
[BP] GO:0002682 regulation of immune system process ADORA1, ALOX15, APP, AXL, BCL2, CA2, CNR1, CNR2, CYP19A1, DUSP3, ESR1, HSPA1A, KIT, MAP3K7, MMP12, MMP2, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, RELA, SMAD3, SRC 5.04559
[BP] GO:0009892 negative regulation of metabolic process ADORA1, AKR1C3, APEX1, APP, AR, AURKB, BCL2, CNR1, CNR2, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, HSPA1A, HTR1B, HTR1E, HTR2B, IGF1R, KDR, MAP2K1, MET, MMP12, MMP9, PIK3CA, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RELA, RORC, SMAD3, SRC, TRPV1, XDH 5.04559
[BP] GO:0045860 positive regulation of protein kinase activity ADORA1, CDC25B, EGFR, FLT3, HTR2A, HTR2B, INSR, KIT, MAP2K1, MAP3K7, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC 5.03885
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, APEX1, AXL, BCL2, CYP1B1, PRKCD, RELA, SRC 4.98114
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, AKR1C3, ALOX15, APEX1, APP, AR, AURKB, BCL2, CA9, CDC25B, CNR1, CNR2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, F3, FABP3, FABP4, FLT3, GLO1, HSPA1A, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RELA, RORC, SMAD3, SRC, TEK, TOP1, TOP2A, TRPV1, XDH 4.95503
[BP] GO:0003006 developmental process involved in reproduction AKR1C3, ALPL, AR, AXL, BCL2, CDC25B, CYP19A1, EGFR, ESR1, HSD17B2, HSD17B3, INSR, KIT, MAP2K1, PTGS2, SRC 4.95503
[BP] GO:0006874 cellular calcium ion homeostasis APP, BCL2, CACNA1C, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 4.94005
[BP] GO:0051347 positive regulation of transferase activity ADORA1, AURKB, CDC25B, EGFR, FLT3, HTR2A, HTR2B, INSR, KIT, MAP2K1, MAP3K7, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC, TEK 4.91491
[BP] GO:0050727 regulation of inflammatory response ADORA1, CNR1, CNR2, CYP19A1, EGFR, ESR1, FABP4, PPARA, PRKCD, PTGS2, RELA, SMAD3, TEK 4.85413
[BP] GO:0007193 None ADORA1, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 4.84052
[BP] GO:0022414 reproductive process AKR1B1, AKR1C3, ALPL, APP, AR, AXL, BCL2, CDC25B, CNR1, CYP19A1, CYP1A1, EGFR, ESR1, HSD11B2, HSD17B2, HSD17B3, INSR, KIT, MAP2K1, MMP2, MMP9, PTGS2, SRC, TOP2A 4.83497
[BP] GO:0009895 negative regulation of catabolic process ADORA1, BCL2, CNR1, EGFR, HTR2B, MET, PIK3CA, PPARA, PRKCG, RELA, SMAD3 4.83497
[BP] GO:0007154 None ADORA1, AKR1C3, AR, AXL, BCL2, CACNA1C, CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PRKCG, PTGS2, TEK, TRPV1 4.83497
[BP] GO:0055074 calcium ion homeostasis APP, BCL2, CACNA1C, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 4.80026
[BP] GO:0071417 cellular response to organonitrogen compound AKR1B1, APEX1, APP, EGFR, HTR1B, IGF1R, INSR, MMP2, PRKCD, PTGS2, RELA, SRC, TRPV1 4.77826
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, APP, AXL, BCL2, CA1, CSNK2A1, EGFR, F3, FLT3, GPR35, IGF1R, INSR, KDR, KIT, MAP3K7, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, PTPN1, RELA, SMAD3, SRC, TEK, TRPV1 4.76813
[BP] GO:0044092 negative regulation of molecular function ADORA3, APP, AURKB, CNR1, CNR2, CSNK2A1, CYP1B1, DUSP3, ESR1, FABP4, GPR35, IGF1R, MET, MMP9, PIM1, PPARA, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SRC 4.75762
[BP] GO:0072503 cellular divalent inorganic cation homeostasis APP, BCL2, CACNA1C, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 4.74551
[BP] GO:0051130 positive regulation of cellular component organization ALOX15, APP, AR, AURKB, AXL, BCL2, CNR1, ESR1, HSPA1A, IGF1R, INSR, KDR, KIT, MAP2K1, MET, MMP1, MMP9, PRKCD, PRKCE, SMAD3, SRC, TEK 4.72899
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ALOX15, AR, BCL2, CNR1, CNR2, CYP19A1, DUSP3, EGFR, ESR1, HSPA1A, IGF1R, MET, MMP12, MMP9, PPARA, PRKCB, PRKCD, PTGS2, PTPN1, RELA, SMAD3, SRC, TEK, XDH 4.7179
[BP] GO:0055080 cation homeostasis APP, BCL2, CA2, CA7, CACNA1C, EGFR, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 4.70778
[BP] GO:0080090 regulation of primary metabolic process ADORA1, ADORA3, AKR1C3, ALOX15, APEX1, APP, AR, AURKB, BCL2, CA9, CDC25B, CNR1, CSNK2A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, F3, FABP3, FABP4, FLT3, GLO1, HSPA1A, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RELA, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 4.70497
[BP] GO:0018105 peptidyl-serine phosphorylation AURKB, BCL2, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TOP1 4.67465
[BP] GO:0031667 response to nutrient levels AKR1C3, ALPL, BCHE, BCL2, CNR1, CYP1A1, EGFR, HSD11B2, PTGS2, RELA, SRC, TRPV1, TYR 4.66857
[BP] GO:0097237 cellular response to toxic substance AKR1B1, APEX1, AXL, CYP1B1, KDR, PRKCD, PRKCE, RELA 4.66571
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, APEX1, APP, AR, AURKB, AXL, BCL2, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HSPA1A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, RELA, RORC, SMAD3, SRC, TEK, TOP1, TOP2A, TRPV1, TYR, XDH 4.66411
[BP] GO:0033273 response to vitamin ALPL, BCHE, CYP1A1, EGFR, PTGS2, RELA, TYR 4.64231
[BP] GO:0043434 None APEX1, FABP3, HSD11B2, INSR, PPARA, PRKCD, PTGS2, RELA, SRC, TEK, TRPV1 4.62139
[BP] GO:0032870 cellular response to hormone stimulus AKR1C3, APEX1, AR, EGFR, ESR1, FLT3, INSR, KIT, PRKCD, PRKCE, RELA, SRC 4.59943
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, AKR1C3, ALOX15, APP, BCL2, CYP19A1, CYP1A1, CYP1B1, HSD17B3, HTR1A, MAOA, TYR 4.57081
[BP] GO:0030003 cellular cation homeostasis APP, BCL2, CA2, CA7, CACNA1C, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 4.54774
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SRC, TEK 4.54162
[BP] GO:0015711 organic anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, SLC22A1, SLC22A2, SLC22A3, TRPV1 4.52799
[BP] GO:0006694 steroid biosynthetic process AKR1B1, AKR1C3, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 4.51809
[BP] GO:0055082 cellular chemical homeostasis APP, BCL2, CA2, CA7, CACNA1C, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CA, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 4.50493
[BP] GO:0071902 positive regulation of protein serine/threonine kinase activity ADORA1, EGFR, FLT3, HTR2A, HTR2B, INSR, KIT, MAP2K1, MAP3K7, PIK3CB, PTPN1, SRC 4.50493
[BP] GO:0031323 regulation of cellular metabolic process ACHE, ADORA1, ADORA3, AKR1C3, ALOX15, APEX1, APP, AR, AURKB, BCL2, CA9, CDC25B, CNR1, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, F3, FABP3, FABP4, FLT3, GLO1, HSPA1A, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RELA, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 4.46327
[BP] GO:0050730 None ADORA1, APP, EGFR, FLT3, HTR2A, KIT, PRKCD, PRKCE, PTPN1, SRC 4.44624
[BP] GO:0007568 aging APEX1, AURKB, BCL2, CNR1, CYP1A1, HTR2A, MAP2K1, PRKCD, PTGS2, RELA 4.44624
[BP] GO:0006873 cellular ion homeostasis APP, BCL2, CA2, CA7, CACNA1C, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 4.42868
[BP] GO:1901699 cellular response to nitrogen compound AKR1B1, APEX1, APP, EGFR, HTR1B, IGF1R, INSR, MMP2, PRKCD, PTGS2, RELA, SRC, TRPV1 4.42527
[BP] GO:0030155 regulation of cell adhesion ALOX15, BCL2, CYP1B1, DUSP3, KDR, MAP3K7, NUAK1, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCE, SMAD3, SRC, TEK 4.37708
[BP] GO:0043279 None BCHE, CNR1, HTR1B, PRKCE, PRKCG, RELA, TRPV1 4.35847
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.35657
[BP] GO:0006954 inflammatory response ADORA1, ADORA3, ALOX15, AXL, CNR2, KIT, PIK3CA, PIK3CB, PTGES, PTGS1, PTGS2, RELA, TRPV1 4.35314
[BP] GO:0014065 phosphatidylinositol 3-kinase signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 4.34525
[BP] GO:0018209 peptidyl-serine modification AURKB, BCL2, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TOP1 4.31726
[BP] GO:0090066 None ADORA1, ALOX15, EGFR, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR7, PRKCD, PRKCE, PTGS2 4.2969
[BP] GO:0051966 regulation of synaptic transmission, glutamatergic ADORA1, CNR1, EGFR, HTR1B, HTR2A, PTGS2 4.26954
[BP] GO:0051094 positive regulation of developmental process APP, AR, AXL, BCL2, CA2, CNR1, CYP1B1, F3, HTR2A, HTR2C, INSR, KDR, KIT, MAP2K1, PIM1, PRKCA, PRKCB, PTGS2, RELA, SMAD3, SRC, TEK 4.23323
[BP] GO:0010863 positive regulation of phospholipase C activity EGFR, ESR1, HTR2A, HTR2B, KIT 4.2138
[BP] GO:0043269 regulation of ion transport ADORA1, APP, BCL2, CA2, CA7, CACNA1C, CNR1, GPR35, HTR1A, HTR1B, HTR2A, MMP9, PRKCD, PRKCE, PTGS2 4.19357
[BP] GO:0070301 cellular response to hydrogen peroxide AKR1B1, APEX1, AXL, CYP1B1, PRKCD, RELA 4.18965
[BP] GO:0031329 regulation of cellular catabolic process APEX1, BCL2, CNR1, HSPA1A, HTR2A, HTR2B, INSR, KDR, MAP3K7, MET, PIK3CA, PIK3CB, PPARA, PRKCA, PRKCD, PRKCG, PTPN1 4.17934
[BP] GO:0019725 cellular homeostasis APEX1, APP, BCL2, CA2, CA7, CACNA1C, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CA, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 4.15798
[BP] GO:0032147 activation of protein kinase activity ADORA1, EGFR, INSR, KIT, MAP2K1, MAP3K7, PIK3CA, PIK3CB, PRKCD, PTPN1, SRC 4.14741
[BP] GO:0032845 None ADORA1, BCL2, HTR2A, HTR2B, HTR2C, PRKCE, SRC, TRPV1 4.11525
[BP] GO:0009605 response to external stimulus ADORA1, AKR1C3, ALPL, AXL, BCHE, BCL2, CNR1, CNR2, CYP1A1, CYP1A2, EGFR, HSD11B2, HTR2A, KIT, MMP12, PRKCD, PTGES, PTGS2, RELA, SMAD3, SRC, TRPV1, TYR 4.07596
[BP] GO:0046889 None FABP3, HTR2A, HTR2B, HTR2C, PRKCD, PTGS2 4.07596
[BP] GO:0060402 None CACNA1C, HTR2A, HTR2B, HTR2C, PRKCE, TRPV1 4.07596
[BP] GO:0055065 metal ion homeostasis APP, BCL2, CACNA1C, EGFR, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 4.04274
[BP] GO:1900274 regulation of phospholipase C activity EGFR, ESR1, HTR2A, HTR2B, KIT 4.03636
[BP] GO:0071248 cellular response to metal ion AKR1C3, ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 4.0363
[BP] GO:0071071 None FABP3, HTR2A, HTR2B, HTR2C 4.03353
[BP] GO:0008217 None ADORA1, AR, CNR1, HSD11B2, PPARA, PTGS1, PTGS2, SMAD3 4.01828
[BP] GO:0061370 testosterone biosynthetic process AKR1C3, CYP19A1, HSD17B3 4.00054
[BP] GO:0071502 None HTR1B, HTR2B, TRPV1 4.00054
[BP] GO:0010513 None HTR2A, HTR2B, HTR2C 4.00054
[BP] GO:0090087 None ACHE, ADORA1, APP, CA2, CACNA1C, CNR1, EGFR, HTR2B, HTR2C, MMP12, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC 3.98837
[BP] GO:0046456 icosanoid biosynthetic process ALOX15, ALOX5, PTGES, PTGS1, PTGS2 3.98717
[BP] GO:0046883 regulation of hormone secretion ADORA1, CACNA1C, CNR1, CYP19A1, EGFR, HTR1A, HTR2A, HTR2C, PRKCA, PRKCE 3.98695
[BP] GO:0032787 None AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, PPARA, PTGES, PTGS1, PTGS2 3.93054
[BP] GO:0048870 cell motility AXL, CNR2, CYP1B1, EGFR, FUT7, HTR2B, HTR6, KDR, KIT, MAP2K1, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PRKCD, SRC, TEK 3.91431
[BP] GO:0051046 None ACHE, ADORA1, CACNA1C, CNR1, CYP19A1, EGFR, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MMP12, PRKCA, PRKCE, SRC, TRPV1 3.90419
[BP] GO:0042180 None AKR1B1, AKR1B10, AKR1C3, CYP19A1, GLO1, HSD17B3 3.90419
[BP] GO:0007188 None ADORA1, CNR1, HTR1A, HTR1B, HTR1D, HTR1E, HTR5A, HTR7 3.88417
[BP] GO:0006875 cellular metal ion homeostasis APP, BCL2, CACNA1C, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PIK3CB, PRKCB, PRKCE, SMAD3, TRPV1 3.8787
[BP] GO:0051171 regulation of nitrogen compound metabolic process ADORA1, ADORA3, ALOX15, APEX1, APP, AR, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1B1, DUSP3, EGFR, ESR1, F3, FABP3, FABP4, FLT3, GLO1, HSPA1A, HTR1A, HTR1B, HTR1E, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RELA, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 3.8767
[BP] GO:0040011 locomotion AXL, CNR2, CYP1B1, EGFR, FUT7, HTR2B, HTR6, KDR, KIT, MAP2K1, MET, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PRKCD, SRC, TEK 3.86987
[BP] GO:0050776 regulation of immune response ALOX15, BCL2, CNR1, DUSP3, ESR1, HSPA1A, KIT, MAP3K7, MMP12, MMP2, PIK3CA, PIK3CB, PRKCB, PRKCD, PRKCE, PTPN1, RELA, SMAD3, SRC 3.86987
[BP] GO:0050890 None ADORA1, APP, BCHE, CNR1, EGFR, HTR2A, INSR, KIT, PRKCG, PTGS2 3.86987
[BP] GO:0031324 negative regulation of cellular metabolic process AKR1C3, APEX1, APP, AR, AURKB, BCL2, CNR1, CSNK2A1, DUSP3, ESR1, FABP4, HSPA1A, HTR1B, HTR1E, HTR2B, IGF1R, MET, MMP12, MMP9, PIK3CA, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RELA, RORC, SMAD3, SRC, TRPV1, XDH 3.86211
[BP] GO:0051701 interaction with host AXL, EGFR, HSPA1A, HTR2A, INSR, MET, SMAD3, SRC 3.85166
[BP] GO:0016477 cell migration AXL, CNR2, CYP1B1, EGFR, FUT7, HTR2B, HTR6, KDR, KIT, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PRKCD, SRC, TEK 3.84502
[BP] GO:0007346 regulation of mitotic cell cycle APEX1, APP, AURKB, BCL2, CDC25B, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, MAP2K1, PIM1, PRKCA, SMAD3, TOP2A 3.81183
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, PTGES, PTGS2, RELA, SRC 3.80663
[BP] GO:0031349 positive regulation of defense response CNR1, EGFR, FABP4, HSPA1A, MAP3K7, MMP12, MMP2, PRKCD, PRKCE, PTGS2, RELA, SRC 3.79223
[BP] GO:1904407 positive regulation of nitric oxide metabolic process EGFR, INSR, PTGS2, SMAD3, TRPV1 3.78605
[BP] GO:0045429 positive regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3, TRPV1 3.78605
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, EGFR, MMP2, MMP9, TEK 3.77243
[BP] GO:0006805 xenobiotic metabolic process BCHE, CYP1A1, CYP1A2, CYP1B1, NQO2, PTGS1, RORC 3.77243
[BP] GO:0050728 negative regulation of inflammatory response ADORA1, CNR2, CYP19A1, PPARA, PRKCD, SMAD3, TEK 3.74829
[BP] GO:0032229 None ADORA1, CNR2, HTR1B 3.73923
[BP] GO:0006464 cellular protein modification process ALPL, APP, AR, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, HTR2B, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TOP1, TOP2A 3.70968
[BP] GO:0036211 protein modification process ALPL, APP, AR, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, HTR2B, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TOP1, TOP2A 3.70968
[BP] GO:0048661 positive regulation of smooth muscle cell proliferation AKR1B1, EGFR, HTR1B, MMP2, MMP9, PTGS2 3.69012
[BP] GO:0060401 None CACNA1C, HTR2A, HTR2B, HTR2C, PRKCE, TRPV1 3.69012
[BP] GO:0019538 protein metabolic process ACHE, ALPL, APP, AR, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F10, F3, FLT3, FUT7, HTR2B, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, RELA, SMAD3, SRC, TEK, TOP1, TOP2A 3.68396
[BP] GO:1903530 regulation of secretion by cell ACHE, ADORA1, CACNA1C, CNR1, CYP19A1, EGFR, HTR1A, HTR1B, HTR2A, HTR2B, HTR2C, MMP12, PRKCA, PRKCE, SRC 3.65117
[BP] GO:0018107 peptidyl-threonine phosphorylation BCL2, CSNK2A1, MAP2K1, PRKCA, PRKCB, PRKCD 3.62748
[BP] GO:0031348 negative regulation of defense response ADORA1, CNR2, CYP19A1, MMP12, PPARA, PRKCD, SMAD3, TEK 3.62279
[BP] GO:0050806 positive regulation of synaptic transmission ADORA1, APP, CA2, CA7, EGFR, PRKCE, PTGS2 3.61547
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, DUSP3, ESR1, HSPA1A, IGF1R, MET, MMP9, PRKCD, PTGS2, PTPN1, RELA, SRC, XDH 3.61212
[BP] GO:0071241 cellular response to inorganic substance AKR1C3, ALOX15, CYP1A1, CYP1A2, EGFR, FABP4, MMP9, PTGS2 3.60757
[BP] GO:0051209 None HTR2A, HTR2B, HTR2C, PRKCE, TRPV1 3.60526
[BP] GO:0051283 None HTR2A, HTR2B, HTR2C, PRKCE, TRPV1 3.60526
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, PTGES, PTGS2, RELA, SRC 3.58068
[BP] GO:0043065 positive regulation of apoptotic process AKR1C3, BCL2, CNR1, CYP1B1, F3, MMP9, PIK3CB, PRKCD, PTGS2, SMAD3, SRC, TOP2A, TRPV1, XDH 3.56132
[BP] GO:0050679 None AR, EGFR, F3, HTR2B, KDR, MMP12, PRKCA, TEK 3.56132
[BP] GO:1904018 positive regulation of vasculature development CYP1B1, F3, KDR, KIT, PRKCA, PRKCB, PTGS2, TEK 3.56132
[BP] GO:0030522 intracellular receptor signaling pathway AR, ESR1, MAP3K7, PIM1, PPARA, RELA, RORC, SRC 3.56132
[BP] GO:0099536 None CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PRKCG 3.54893
[BP] GO:0099537 None CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PRKCG 3.54893
[BP] GO:0007611 None APP, BCHE, CNR1, EGFR, HTR2A, INSR, KIT, PRKCG, PTGS2 3.53865
[BP] GO:0045787 positive regulation of cell cycle APEX1, APP, AURKB, CDC25B, CYP1A1, DUSP3, EGFR, INSR, PRKCA, PRKCE, SRC 3.534
[BP] GO:0040016 embryonic cleavage PIK3CB, TOP1, TOP2A 3.52979
[BP] GO:0010511 None HTR2A, HTR2B, HTR2C 3.52979
[BP] GO:0033554 cellular response to stress AKR1B1, AKR1C3, ALOX15, APEX1, AXL, BCL2, CA2, CA9, CYP1B1, EGFR, HSPA1A, MAP2K1, MAP3K7, MMP9, NUAK1, PRKCD, PRKCE, PTGS2, PTPN1, RELA, SRC, TOP2A, TRPV1 3.52979
[BP] GO:0038083 peptidyl-tyrosine autophosphorylation EGFR, IGF1R, INSR, KDR, SRC 3.52848
[BP] GO:0043068 positive regulation of programmed cell death AKR1C3, BCL2, CNR1, CYP1B1, F3, MMP9, PIK3CB, PRKCD, PTGS2, SMAD3, SRC, TOP2A, TRPV1, XDH 3.52728
[BP] GO:1901654 None AKR1B1, AR, CA9, CSNK2A1, EGFR, PRKCE, RELA, SRC 3.52043
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, EGFR, PPARA, SMAD3 3.5036
[BP] GO:0006939 None HTR1D, HTR2A, HTR2B, HTR7, TRPV1 3.48702
[BP] GO:0097164 None ACHE, AKR1B1, AKR1B10, AKR1C3, BCHE, CSNK2A1, HTR1A, MAOA 3.45379
[BP] GO:0046626 regulation of insulin receptor signaling pathway PRKCB, PRKCD, PTPN1, RELA, SRC 3.4475
[BP] GO:0010518 positive regulation of phospholipase activity EGFR, ESR1, HTR2A, HTR2B, KIT 3.4475
[BP] GO:0018210 peptidyl-threonine modification BCL2, CSNK2A1, MAP2K1, PRKCA, PRKCB, PRKCD 3.44603
[BP] GO:0046683 response to organophosphorus APEX1, APP, PTGS2, RELA, TEK, TRPV1, TYR 3.44434
[BP] GO:0044267 cellular protein metabolic process ALPL, APP, AR, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, HTR2B, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP2, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TOP1, TOP2A 3.40858
[BP] GO:0006820 anion transport CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA, SLC22A1, SLC22A2, SLC22A3, TRPV1 3.40217
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.37773
[BP] GO:0032098 None HTR2C, HTR4, PPARA, SLC22A3 3.37773
[BP] GO:0051090 regulation of DNA binding transcription factor activity ADORA3, APP, AR, CYP1B1, ESR1, HSPA1A, KIT, MAP3K7, PIM1, PRKCB, RELA 3.37536
[BP] GO:0042133 neurotransmitter metabolic process ACHE, BCHE, CYP1B1, HTR1A, MAOA, SLC22A2 3.36724
[BP] GO:0010810 regulation of cell-substrate adhesion ALOX15, BCL2, KDR, PIK3CB, PRKCE, SMAD3, SRC, TEK 3.36456
[BP] GO:0044597 None AKR1B1, AKR1B10, AKR1C3 3.35332
[BP] GO:0044598 None AKR1B1, AKR1B10, AKR1C3 3.35332
[BP] GO:0030638 None AKR1B1, AKR1B10, AKR1C3 3.35332
[BP] GO:1903428 positive regulation of reactive oxygen species biosynthetic process EGFR, INSR, PTGS2, SMAD3, TRPV1 3.33488
[BP] GO:0050994 None ADORA1, CNR1, PPARA, PRKCD, PRKCE 3.33488
[BP] GO:0006952 defense response ADORA1, ADORA3, ALOX15, APP, AXL, BCL2, CNR2, HTR1A, HTR2C, KIT, PIK3CA, PIK3CB, PRKCD, PTGES, PTGS1, PTGS2, RELA, SRC, TRPV1 3.33445
[BP] GO:0050793 regulation of developmental process APP, AR, AXL, BCL2, CA2, CNR1, CYP1B1, EGFR, ESR1, F3, HTR2A, HTR2C, INSR, KDR, KIT, MAP2K1, NUAK1, PIK3CA, PIM1, PPARA, PRKCA, PRKCB, PTGS2, RELA, RORC, SMAD3, SRC, TEK, TRPV1, XDH 3.2924
[BP] GO:0050794 regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, ALOX15, APEX1, APP, AR, AURKB, AXL, BCHE, BCL2, CA1, CA2, CA7, CA9, CACNA1C, CDC25B, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, DUSP3, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, GLO1, GPR35, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, RELA, RORC, SMAD3, SRC, TEK, TOP2A, TRPV1, XDH 3.27869
[BP] GO:0080135 regulation of cellular response to stress APP, DUSP3, EGFR, HSPA1A, IGF1R, MAP2K1, MAP3K7, MET, NUAK1, PRKCD, PRKCG, PTGS2, PTPN1, XDH 3.27778
[BP] GO:0051384 response to glucocorticoid ALPL, BCHE, BCL2, EGFR, FLT3, HSD11B2, PTGS2 3.27459
[BP] GO:0006693 None AKR1C3, PTGES, PTGS1, PTGS2 3.25203
[BP] GO:0006692 None AKR1C3, PTGES, PTGS1, PTGS2 3.25203
[BP] GO:0050678 None AR, EGFR, F3, HTR2B, KDR, MMP12, PRKCA, SMAD3, TEK, XDH 3.22254
[BP] GO:0044089 positive regulation of cellular component biogenesis ALOX15, ESR1, HSPA1A, KDR, KIT, MET, MMP1, PRKCA, PRKCE, SMAD3, SRC, TEK 3.21372
[BP] GO:0043412 macromolecule modification ALPL, APEX1, APP, AR, AURKB, AXL, BCL2, CDC25B, CSNK2A1, DUSP3, EGFR, ESR1, F10, FLT3, FUT7, HTR2B, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TOP1, TOP2A 3.20595
[BP] GO:0010942 positive regulation of cell death AKR1C3, BCL2, CNR1, CYP1B1, F3, MMP9, PIK3CB, PRKCD, PTGS2, SMAD3, SRC, TOP2A, TRPV1, XDH 3.20269
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MMP9, PTGS2, PTPN1, SRC 3.20269
[BP] GO:0030647 None AKR1B1, AKR1B10, AKR1C3 3.20269
[BP] GO:0046686 response to cadmium ion AKR1C3, CYP1A2, EGFR, KIT, MMP9 3.19769
[BP] GO:0045931 positive regulation of mitotic cell cycle APEX1, APP, CDC25B, CYP1A1, DUSP3, INSR, PRKCA 3.19065
[BP] GO:0006928 movement of cell or subcellular component APP, AXL, CNR2, CYP1B1, EGFR, FUT7, HTR2B, HTR6, KDR, KIT, MAP2K1, MMP1, MMP12, MMP9, PIK3CA, PIK3CB, PRKCA, PRKCD, PTGS2, SRC, TEK 3.18248
[BP] GO:0097553 None HTR2A, HTR2B, HTR2C, PRKCE, TRPV1 3.16494
[BP] GO:0072347 None CNR1, HTR1B, PRKCE, PRKCG, RELA 3.16494
[BP] GO:0045428 regulation of nitric oxide biosynthetic process EGFR, INSR, PTGS2, SMAD3, TRPV1 3.16494
[BP] GO:0051726 regulation of cell cycle APEX1, APP, AURKB, BCL2, CDC25B, CSNK2A1, CYP1A1, DUSP3, EGFR, HSPA1A, INSR, MAP2K1, PIM1, PRKCA, PRKCE, PTGS2, SMAD3, SRC, TOP2A 3.16494
[BP] GO:0014074 response to purine-containing compound APEX1, APP, PTGS2, RELA, TEK, TRPV1, TYR 3.15859
[BP] GO:0009410 None CNR1, CNR2, EGFR, HTR1B, PRKCE, PRKCG, RELA 3.15859
[BP] GO:0051051 negative regulation of transport ADORA1, APP, BCL2, CNR1, GPR35, HSPA1A, HTR1B, HTR2A, MMP9, PRKCB, PRKCE, PTGS2 3.14271
[BP] GO:0016572 histone phosphorylation AURKB, PRKCA, PRKCB, PRKCD 3.14117
[BP] GO:0051050 positive regulation of transport ACHE, ADORA1, APP, AXL, BCL2, CA2, CYP19A1, EGFR, HTR2B, INSR, MMP12, PRKCD, PRKCE, PTGS2, SMAD3, SRC, TRPV1 3.13377
[BP] GO:0043393 regulation of protein binding APP, AURKB, BCL2, MET, MMP9, PPARA, PRKCD, SRC 3.13171
[BP] GO:0010517 regulation of phospholipase activity EGFR, ESR1, HTR2A, HTR2B, KIT 3.10056
[BP] GO:0009266 None ADORA1, HSPA1A, HTR1B, HTR2A, HTR2B, PTGS2, TRPV1 3.09062
[BP] GO:1901653 cellular response to peptide AKR1B1, APEX1, APP, IGF1R, INSR, PRKCD, RELA, SRC 3.09062
[BP] GO:0006636 unsaturated fatty acid biosynthetic process ALOX15, PTGES, PTGS1, PTGS2 3.08724
[BP] GO:0051828 entry into other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.07431
[BP] GO:0030260 entry into host cell AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.07431
[BP] GO:0051806 entry into cell of other organism involved in symbiotic interaction AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.07431
[BP] GO:0044409 entry into host AXL, EGFR, HSPA1A, HTR2A, MET, SRC 3.07431
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.07393
[BP] GO:0009987 cellular process ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, APEX1, APP, AR, AURKB, AXL, BCHE, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CACNA1C, CBR1, CDC25B, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, FUT7, GLO1, GPR35, HSD17B1, HSD17B2, HSD17B3, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, RELA, RORC, SLC22A1, SLC22A2, SMAD3, SRC, TEK, TOP1, TOP2A, TRPV1, TYR, XDH 3.06516
[BP] GO:0048869 cellular developmental process ACHE, AKR1C3, ALPL, APP, AR, AXL, BCHE, BCL2, CBR1, CDC25B, CYP1A1, EGFR, ESR1, FABP4, FLT3, FUT7, GLO1, HTR2B, KDR, KIT, MAP2K1, MET, MMP2, MMP9, PRKCD, PTGS2, RORC, SMAD3, SRC, TEK, TOP2A 3.06304
[BP] GO:0006811 None CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, FABP3, HTR2A, HTR2B, HTR2C, PPARA, PRKCB, PRKCE, SLC22A1, SLC22A2, SLC22A3, SLC47A1, TRPV1 3.05576
[BP] GO:2001234 negative regulation of apoptotic signaling pathway AR, BCL2, HSPA1A, MMP9, PTGS2, PTPN1, RELA, SRC 3.05563
[BP] GO:0048015 phosphatidylinositol-mediated signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 3.04313
[BP] GO:0060255 regulation of macromolecule metabolic process ACHE, ADORA1, ADORA3, ALOX15, APEX1, APP, AR, AURKB, BCL2, CA9, CDC25B, CSNK2A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, F3, FABP4, FLT3, GLO1, HSPA1A, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RELA, RORC, SMAD3, SRC, TEK, TOP1, TOP2A, TRPV1, XDH 3.04313
[BP] GO:0035265 organ growth AR, BCL2, CYP19A1, ESR1 3.04014
[BP] GO:0046627 None PRKCB, PRKCD, PTPN1, RELA 3.04014
[BP] GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity FLT3, KIT, SRC, TEK 3.04014
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, KDR, PIK3CB, SMAD3, SRC, TEK 3.03603
[BP] GO:0045766 positive regulation of angiogenesis CYP1B1, F3, KDR, PRKCA, PRKCB, PTGS2, TEK 3.03412
[BP] GO:0032103 positive regulation of response to external stimulus CNR1, EGFR, F3, FABP4, KDR, MET, PRKCA, PTGS2, SMAD3 3.03324
[BP] GO:0060193 positive regulation of lipase activity EGFR, ESR1, HTR2A, HTR2B, KIT 3.01548
[BP] GO:0010632 regulation of epithelial cell migration KDR, MET, MMP9, PRKCA, PRKCE, PTGS2, SRC, TEK 3.00719
[BP] GO:0032872 regulation of stress-activated MAPK cascade APP, DUSP3, EGFR, IGF1R, MAP2K1, MAP3K7, PTPN1, XDH 3.00719
[BP] GO:0002009 morphogenesis of an epithelium AR, BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 3.00029
[BP] GO:0070302 regulation of stress-activated protein kinase signaling cascade APP, DUSP3, EGFR, IGF1R, MAP2K1, MAP3K7, PTPN1, XDH 2.99456
[BP] GO:0071276 cellular response to cadmium ion AKR1C3, CYP1A2, EGFR, MMP9 2.99024
[BP] GO:0071396 cellular response to lipid AKR1C3, AR, AXL, EGFR, ESR1, FLT3, PRKCE, RELA, RORC, SRC 2.98944
[BP] GO:0023052 None ADORA1, AR, CACNA1C, CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PRKCG, TEK 2.98429
[BP] GO:0044057 None ADORA1, ADORA3, CACNA1C, EGFR, GPR35, HTR2A, HTR2C, KIT, PRKCA, PTGS2, SMAD3, TRPV1 2.98229
[BP] GO:0044236 multicellular organism metabolic process AKR1C3, MMP1, MMP12, MMP2, MMP9, TRPV1 2.97604
[BP] GO:0051480 regulation of cytosolic calcium ion concentration CACNA1C, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PRKCE, SMAD3, TRPV1 2.97049
[BP] GO:0002320 lymphoid progenitor cell differentiation BCL2, FLT3, KIT 2.96159
[BP] GO:0060736 prostate gland growth AR, CYP19A1, ESR1 2.96159
[BP] GO:0006855 None SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2 2.96159
[BP] GO:0048017 inositol lipid-mediated signaling HTR2A, HTR2B, IGF1R, PIK3CA, PIK3CB 2.96159
[BP] GO:0006721 terpenoid metabolic process AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1, EGFR 2.95919
[BP] GO:0008285 negative regulation of cell proliferation ADORA1, ADORA3, APP, AR, BCHE, BCL2, CYP1B1, FABP3, HSPA1A, MAP2K1, PTGES, PTGS2, SMAD3, XDH 2.95919
[BP] GO:0043278 None CNR1, PRKCE, PRKCG, RELA 2.94702
[BP] GO:0014072 None CNR1, PRKCE, PRKCG, RELA 2.94702
[BP] GO:0008406 gonad development AKR1C3, BCL2, CYP19A1, ESR1, INSR, KIT 2.94066
[BP] GO:0006081 None AKR1B10, AKR1C3, CYP1B1, GLO1, RELA 2.9349
[BP] GO:0009891 positive regulation of biosynthetic process APP, AR, AURKB, EGFR, ESR1, FABP3, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, MAP2K1, MET, MMP12, PPARA, PRKCD, PTGS2, RELA, RORC, SMAD3, SRC, TOP2A, TRPV1 2.93439
[BP] GO:0002684 positive regulation of immune system process APP, AXL, BCL2, CA2, CNR1, HSPA1A, MAP3K7, MMP12, MMP2, PIK3CA, PIK3CB, PRKCA, PRKCB, PRKCD, PRKCE, RELA, SRC 2.92626
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AKR1C3, BCHE, CBR1, CYP1A1, CYP1A2, CYP1B1, EGFR, HSPA1A, MAOA 2.9243
[BP] GO:0009896 positive regulation of catabolic process CSNK2A1, HSPA1A, HTR2A, INSR, KDR, MAP3K7, PIK3CB, PPARA, PRKCD, PRKCE, PTPN1 2.914
[BP] GO:0007268 None HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PRKCG 2.914
[BP] GO:0098916 None HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PRKCG 2.914
[BP] GO:0007208 None HTR2A, HTR2C 2.914
[BP] GO:0016488 None AKR1B10, AKR1C3 2.914
[BP] GO:0016487 None AKR1B10, AKR1C3 2.914
[BP] GO:0035408 None PRKCA, PRKCB 2.914
[BP] GO:0016107 None AKR1B10, AKR1C3 2.914
[BP] GO:0006714 None AKR1B10, AKR1C3 2.914
[BP] GO:1900077 None PRKCB, PRKCD, PTPN1, RELA 2.914
[BP] GO:0090218 positive regulation of lipid kinase activity FLT3, KIT, SRC, TEK 2.914
[BP] GO:0051128 regulation of cellular component organization ALOX15, APP, AR, AURKB, AXL, BCL2, CNR1, CSNK2A1, EGFR, ESR1, HSPA1A, IGF1R, INSR, KDR, KIT, MAP2K1, MET, MMP1, MMP9, PIK3CB, PRKCD, PRKCE, PRKCG, PTPN1, SMAD3, SRC, TEK, TOP2A 2.89944
[BP] GO:1900076 regulation of cellular response to insulin stimulus PRKCB, PRKCD, PTPN1, RELA, SRC 2.89306
[BP] GO:0007267 None ADORA1, AR, CNR1, HTR1B, HTR1D, HTR1E, HTR2A, HTR2C, HTR4, HTR6, HTR7, PRKCG, TEK 2.87517
[BP] GO:0002791 None ACHE, ADORA1, CACNA1C, CNR1, EGFR, HTR2B, HTR2C, MMP12, PRKCA, PRKCE, SRC 2.87517
[BP] GO:0015697 None SLC22A1, SLC22A2, SLC22A3 2.87517
[BP] GO:0045759 None CNR1, CNR2, GPR35 2.87517
[BP] GO:0015872 None SLC22A1, SLC22A2, SLC22A3 2.87517
[BP] GO:0050789 regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, AKR1C3, ALOX15, APEX1, APP, AR, AURKB, AXL, BCHE, BCL2, CA1, CA2, CA7, CA9, CACNA1C, CDC25B, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, GLO1, GPR35, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, RELA, RORC, SMAD3, SRC, TEK, TOP1, TOP2A, TRPV1, XDH 2.87444
[BP] GO:0045913 None HTR2A, INSR, PPARA, PRKCE, SRC 2.87005
[BP] GO:0051282 None CACNA1C, HTR2A, HTR2B, HTR2C, PRKCE, TRPV1 2.86262
[BP] GO:0048534 hematopoietic or lymphoid organ development BCL2, FLT3, KDR, KIT, MAP2K1, TEK, TYR 2.86262
[BP] GO:0046890 None AKR1C3, FABP3, HTR2A, HTR2B, HTR2C, PRKCD, PTGS2 2.86262
[BP] GO:0032880 regulation of protein localization ACHE, APP, AR, BCL2, CACNA1C, CNR1, CSNK2A1, EGFR, HTR2B, MMP12, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC 2.85094
[BP] GO:0070201 None ACHE, APP, BCL2, CACNA1C, CNR1, EGFR, HTR2B, MMP12, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC 2.84213
[BP] GO:2001233 regulation of apoptotic signaling pathway AR, BCL2, HSPA1A, MMP9, PRKCD, PTGS2, PTPN1, RELA, SMAD3, SRC 2.79002
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.77353
[BP] GO:0032230 positive regulation of synaptic transmission, GABAergic CA2, CA7, PRKCE 2.77353
[BP] GO:0001516 None PTGES, PTGS1, PTGS2 2.77353
[BP] GO:0046457 None PTGES, PTGS1, PTGS2 2.77353
[BP] GO:0048871 multicellular organismal homeostasis ADORA1, AKR1B1, HTR2A, MET, PIK3CA, TRPV1 2.76558
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 2.76099
[BP] GO:0071383 None AKR1C3, AR, EGFR, FLT3, SRC 2.70589
[BP] GO:0048806 genitalia development AXL, CYP19A1, ESR1, HSD17B3 2.69379
[BP] GO:0015695 None SLC22A1, SLC22A2, SLC22A3, SLC47A1 2.69379
[BP] GO:0051091 positive regulation of DNA binding transcription factor activity APP, AR, ESR1, HSPA1A, KIT, MAP3K7, PRKCB, RELA 2.69371
[BP] GO:0038093 Fc receptor signaling pathway KIT, MAP3K7, PIK3CA, PIK3CB, PRKCD, PRKCE, RELA, SRC 2.68273
[BP] GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling APP, ESR1, HTR2B, MAP3K7, PRKCB, PRKCE, PTGS2, RELA 2.68273
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.68085
[BP] GO:0051967 None ADORA1, HTR1B, HTR2A 2.68085
[BP] GO:0034097 response to cytokine ALOX15, AXL, BCL2, FABP4, FLT3, PRKCA, PTGES, PTGS2, RELA, SRC, TRPV1 2.67719
[BP] GO:0071363 cellular response to growth factor stimulus APP, EGFR, INSR, KDR, RELA, SMAD3, SRC, TRPV1 2.67338
[BP] GO:0038128 None EGFR, PIK3CA, PRKCA, SRC 2.65489
[BP] GO:0019752 carboxylic acid metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, PIM1, PPARA, PTGES, PTGS1, PTGS2, TYR 2.65439
[BP] GO:0046649 lymphocyte activation AXL, BCL2, FLT3, FUT7, KIT, PRKCB, PRKCD, RORC, SMAD3 2.64363
[BP] GO:0007204 positive regulation of cytosolic calcium ion concentration CACNA1C, ESR1, GPR35, HTR2A, HTR2B, HTR2C, PRKCE, TRPV1 2.63961
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, AKR1C3, CYP1A1, CYP1A2, CYP1B1, EGFR 2.63961
[BP] GO:0009968 negative regulation of signal transduction AR, BCL2, DUSP3, EGFR, ESR1, HSPA1A, IGF1R, MET, MMP12, MMP9, PRKCB, PRKCD, PTGS2, PTPN1, RELA, SMAD3, SRC, XDH 2.63525
[BP] GO:0042391 None ADORA1, APP, BCL2, CACNA1C, CNR1, CNR2, GPR35, KDR, SRC, TRPV1 2.63424
[BP] GO:0050878 regulation of body fluid levels ADORA1, AKR1B1, F10, F3, MET, PRKCA, PRKCD, PRKCE, SLC22A2, XDH 2.63424
[BP] GO:0031328 positive regulation of cellular biosynthetic process APP, AR, AURKB, EGFR, ESR1, FABP3, HTR2A, HTR2B, HTR2C, IGF1R, INSR, MAP2K1, MET, MMP12, PPARA, PRKCD, PTGS2, RELA, RORC, SMAD3, SRC, TOP2A, TRPV1 2.62839
[BP] GO:0018958 None AKR1B1, BCL2, HTR1A, MAOA, TYR 2.61071
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALOX15, CSNK2A1, EGFR, FABP3, FABP4, KIT, MET, PIK3CA, PIK3CB 2.60056
[BP] GO:0050961 None ADORA1, HTR2A, TRPV1 2.59881
[BP] GO:0050965 None ADORA1, HTR2A, TRPV1 2.59881
[BP] GO:1903798 None EGFR, ESR1, MAP2K1 2.59881
[BP] GO:0051937 None SLC22A1, SLC22A2, SLC22A3 2.59881
[BP] GO:0043123 None APP, HTR2B, MAP3K7, PRKCB, PRKCE, PTGS2, RELA 2.59703
[BP] GO:0048660 regulation of smooth muscle cell proliferation AKR1B1, EGFR, HTR1B, MMP2, MMP9, PTGS2 2.59218
[BP] GO:0070542 None AKR1C3, FABP3, PRKCE, PTGS2, SRC 2.56562
[BP] GO:1901570 None ALOX15, ALOX5, PTGES, PTGS1, PTGS2 2.56562
[BP] GO:1900182 positive regulation of protein localization to nucleus APP, EGFR, PRKCD, PTGS2, SMAD3, SRC 2.55701
[BP] GO:0001525 angiogenesis CYP1B1, KDR, MMP2, PIK3CA, PIK3CB, PRKCA, PTGS2, TEK 2.55661
[BP] GO:1901342 regulation of vasculature development CYP1B1, F3, KDR, KIT, PRKCA, PRKCB, PTGS2, TEK, XDH 2.54637
[BP] GO:1901224 None APP, EGFR, MAP3K7, RELA 2.5441
[BP] GO:1901655 None AKR1B1, AR, EGFR, PRKCE, SRC 2.54356
[BP] GO:0002768 immune response-regulating cell surface receptor signaling pathway BCL2, KIT, MAP3K7, PIK3CA, PIK3CB, PRKCB, PRKCD, PRKCE, RELA, SRC 2.54127
[BP] GO:0051223 None ACHE, APP, CACNA1C, CNR1, EGFR, HTR2B, MMP12, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, SMAD3, SRC 2.52984
[BP] GO:0050673 epithelial cell proliferation ESR1, KIT, MAP2K1, PIK3CB, TEK 2.5246
[BP] GO:1903426 None EGFR, INSR, PTGS2, SMAD3, TRPV1 2.5246
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.5246
[BP] GO:0032075 None HSPA1A, PRKCD, PTPN1 2.5246
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.5246
[BP] GO:0070920 None EGFR, ESR1, MAP2K1 2.5246
[BP] GO:0019372 lipoxygenase pathway ALOX15, ALOX5, PTGS2 2.5246
[BP] GO:0009411 response to UV AURKB, BCL2, EGFR, PTGS2, RELA, TYR 2.51322
[BP] GO:0001936 None F3, HTR2B, KDR, PRKCA, TEK, XDH 2.51322
[BP] GO:0043551 regulation of phosphatidylinositol 3-kinase activity FLT3, KIT, SRC, TEK 2.51315
[BP] GO:0002521 leukocyte differentiation AXL, BCL2, FLT3, FUT7, GLO1, KIT, MMP9, RORC 2.5123
[BP] GO:0001816 cytokine production APP, FABP4, KIT, PRKCD, PTGS2 2.5123
[BP] GO:0033590 None EGFR, RELA 2.5123
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.5123
[BP] GO:0002520 None CACNA1C, SMAD3 2.5123
[BP] GO:0016095 None AKR1B10, AKR1C3 2.5123
[BP] GO:0045597 positive regulation of cell differentiation APP, AR, AXL, BCL2, CA2, CNR1, HTR2A, HTR2C, KDR, KIT, MAP2K1, PRKCA, PTGS2, RELA, SMAD3 2.48887
[BP] GO:0050999 None CNR1, CNR2, EGFR, HTR2B 2.48801
[BP] GO:0060191 regulation of lipase activity EGFR, ESR1, HTR2A, HTR2B, KIT 2.46845
[BP] GO:0010595 positive regulation of endothelial cell migration KDR, MET, PRKCA, PTGS2, TEK 2.46845
[BP] GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress BCL2, CYP1B1, PRKCD 2.46148
[BP] GO:0051098 regulation of binding APP, AURKB, BCL2, MET, MMP9, PPARA, PRKCD, SMAD3, SRC 2.45699
[BP] GO:0045088 regulation of innate immune response ESR1, HSPA1A, MAP3K7, MMP12, MMP2, PRKCD, PRKCE, PTPN1, RELA, SRC 2.45682
[BP] GO:0044259 multicellular organismal macromolecule metabolic process AKR1C3, MMP1, MMP12, MMP2, MMP9 2.44921
[BP] GO:0001938 None F3, HTR2B, KDR, PRKCA, TEK 2.44921
[BP] GO:1904951 positive regulation of establishment of protein localization ACHE, APP, BCL2, EGFR, HTR2B, MMP12, PRKCD, PRKCE, PTGS2, SMAD3, SRC 2.43922
[BP] GO:0032868 None FABP3, HSD11B2, INSR, PPARA, RELA, SRC 2.43029
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, AKR1C3, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4 2.43
[BP] GO:0051172 None APEX1, APP, AR, AURKB, CSNK2A1, DUSP3, EGFR, ESR1, FABP4, HSPA1A, HTR1B, HTR1E, IGF1R, MMP12, MMP9, PPARA, PRKCA, PRKCD, PRKCE, PRKCG, PTGS2, PTPN1, RELA, RORC, SMAD3, SRC, TRPV1, XDH 2.42469
[BP] GO:0051092 positive regulation of NF-kappaB transcription factor activity APP, AR, HSPA1A, MAP3K7, PRKCB, RELA 2.41524
[BP] GO:0030154 cell differentiation AKR1C3, ALPL, AR, AXL, BCHE, BCL2, CBR1, CYP1A1, ESR1, FABP4, FLT3, FUT7, GLO1, HTR2B, KDR, KIT, MAP2K1, MMP2, MMP9, PTGS2, RORC, SMAD3, TOP2A 2.41437
[BP] GO:0043207 response to external biotic stimulus ALPL, AXL, BCL2, CNR1, CNR2, CYP1A1, CYP1A2, MMP12, PRKCD, PTGES, PTGS2, RELA, SMAD3, SRC 2.41309
[BP] GO:0060359 None CNR1, HTR1B, PRKCE, PRKCG, RELA 2.40805
[BP] GO:0072488 None SLC22A1, SLC22A2, SLC22A3 2.39516
[BP] GO:0016137 None AKR1B1, AKR1B10, AKR1C3 2.39516
[BP] GO:0050900 leukocyte migration CNR2, FUT7, KIT, MMP1, MMP9, PIK3CA, PIK3CB, SRC, TEK 2.39235
[BP] GO:0010638 positive regulation of organelle organization ALOX15, AURKB, BCL2, HSPA1A, INSR, KDR, MET, MMP9, PRKCE, SMAD3, SRC, TEK 2.38989
[BP] GO:0000187 activation of MAPK activity INSR, KIT, MAP2K1, MAP3K7, PIK3CB, PTPN1 2.37084
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, F3, MMP9, PTGS2, SMAD3, SRC, XDH 2.36654
[BP] GO:0048729 tissue morphogenesis AR, BCL2, CA2, CA9, EGFR, ESR1, MET, SMAD3, SRC 2.35867
[BP] GO:0044283 None AKR1B1, AKR1C3, ALOX15, ALOX5, CYP19A1, CYP1A1, HSD17B3, PTGES, PTGS1, PTGS2 2.35612
[BP] GO:0070848 response to growth factor APP, EGFR, INSR, KDR, RELA, SMAD3, SRC, TRPV1 2.34284
[BP] GO:0050778 positive regulation of immune response BCL2, CNR1, HSPA1A, MAP3K7, MMP12, MMP2, PIK3CA, PIK3CB, PRKCB, PRKCD, PRKCE, RELA, SRC 2.33756
[BP] GO:0016048 None ADORA1, HTR2A, TRPV1 2.32973
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.32973
[BP] GO:0008584 None AKR1C3, BCL2, ESR1, INSR, KIT 2.32715
[BP] GO:0051704 multi-organism process APP, AXL, BCL2, CYP1A1, EGFR, HSD11B2, HSPA1A, HTR2A, INSR, KDR, MAP2K1, MET, MMP1, MMP12, PRKCD, RELA, SMAD3, SRC, TOP1 2.32382
[BP] GO:0015893 None CA2, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2 2.29792
[BP] GO:0009416 response to light stimulus APP, AURKB, BCL2, EGFR, KIT, PTGS2, RELA, TYR 2.28624
[BP] GO:0051054 positive regulation of DNA metabolic process AURKB, EGFR, IGF1R, INSR, PRKCD, PRKCG, SRC 2.28624
[BP] GO:0045321 leukocyte activation ALOX5, AXL, BCL2, FLT3, FUT7, HSPA1A, KIT, MMP9, PRKCB, PRKCD, PRKCE, RORC, SMAD3, TRPV1 2.24975
[BP] GO:0051591 None APEX1, APP, RELA, TEK, TYR 2.24975
[BP] GO:0003014 None ADORA1, AKR1B1, AKR1C3, BCL2, HSD11B2 2.24975
[BP] GO:0043436 oxoacid metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, PIM1, PPARA, PTGES, PTGS1, PTGS2, TYR 2.24975
[BP] GO:1901374 None SLC22A1, SLC22A2 2.24975
[BP] GO:0038171 None CNR1, CNR2 2.24975
[BP] GO:0015874 None SLC22A1, SLC22A2 2.24975
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.24975
[BP] GO:0014827 None HTR1D, HTR2B 2.24975
[BP] GO:0009607 response to biotic stimulus ALPL, AXL, BCL2, CNR1, CNR2, CYP1A1, CYP1A2, MMP12, PRKCD, PTGES, PTGS2, RELA, SMAD3, SRC 2.24565
[BP] GO:0010676 None INSR, PPARA, PRKCE, SRC 2.23999
[BP] GO:0043550 regulation of lipid kinase activity FLT3, KIT, SRC, TEK 2.23999
[BP] GO:0014066 regulation of phosphatidylinositol 3-kinase signaling EGFR, FLT3, KDR, KIT, TEK 2.23461
[BP] GO:0016101 None AKR1B10, AKR1C3, CYP1A1, CYP1B1, EGFR 2.23461
[BP] GO:0030100 regulation of endocytosis ALOX15, APP, AXL, PIK3CB, PRKCG, PTPN1, SRC 2.2245
[BP] GO:0048609 multicellular organismal reproductive process AKR1B1, APP, AR, AXL, CNR1, CYP1A1, EGFR, ESR1, KIT, PTGS2, SRC 2.22305
[BP] GO:2000026 regulation of multicellular organismal development APP, AR, AXL, BCL2, CA2, CNR1, CYP1B1, EGFR, ESR1, F3, INSR, KDR, KIT, MAP2K1, PIM1, PRKCA, PRKCB, PTGS2, RELA, SMAD3, SRC, TEK, XDH 2.22102
[BP] GO:0042307 positive regulation of protein import into nucleus APP, EGFR, PRKCD, PTGS2, SMAD3 2.21866
[BP] GO:0042752 None ADORA1, PPARA, PRKCG, RORC, TOP2A 2.21866
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.21866
[BP] GO:0015844 None SLC22A1, SLC22A2, SLC22A3 2.21866
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.21866
[BP] GO:0098900 None CACNA1C, CNR1, CNR2, GPR35 2.21546
[BP] GO:0033138 positive regulation of peptidyl-serine phosphorylation APP, BCL2, EGFR, PIK3CA, PTGS2 2.20078
[BP] GO:0046854 phosphatidylinositol phosphorylation EGFR, KIT, MET, PIK3CA, PIK3CB 2.20078
[BP] GO:0023014 signal transduction by protein phosphorylation EGFR, HTR2B, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, TEK 2.19237
[BP] GO:0051336 regulation of hydrolase activity APP, CSNK2A1, EGFR, ESR1, F3, HSPA1A, HTR2A, HTR2B, KIT, MMP9, NUAK1, PRKCD, PTGS2, PTPN1, SMAD3, SRC, XDH 2.18847
[BP] GO:0051893 regulation of focal adhesion assembly KDR, SMAD3, SRC, TEK 2.18829
[BP] GO:0033555 multicellular organismal response to stress BCL2, HTR1A, HTR2C, PRKCG 2.18829
[BP] GO:0090109 regulation of cell-substrate junction assembly KDR, SMAD3, SRC, TEK 2.18829
[BP] GO:0050865 regulation of cell activation APP, AXL, BCL2, CNR1, CNR2, DUSP3, MAP3K7, PIK3CA, PRKCA, PRKCD, SRC 2.18553
[BP] GO:1904591 positive regulation of protein import APP, EGFR, PRKCD, PTGS2, SMAD3 2.18543
[BP] GO:0000904 cell morphogenesis involved in differentiation AR, AXL, MET, SRC, TEK 2.18543
[BP] GO:0006082 organic acid metabolic process AKR1C3, ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, FABP3, GLO1, PIM1, PPARA, PTGES, PTGS1, PTGS2, TYR 2.18471
[BP] GO:0002429 immune response-activating cell surface receptor signaling pathway BCL2, MAP3K7, PIK3CA, PIK3CB, PRKCB, PRKCD, PRKCE, RELA, SRC 2.17253
[BP] GO:2001242 regulation of intrinsic apoptotic signaling pathway BCL2, HSPA1A, MMP9, PTGS2, PTPN1, SRC 2.17205
[BP] GO:0031334 positive regulation of protein complex assembly ALOX15, ESR1, HSPA1A, MET, MMP1, PRKCE, SRC 2.16746
[BP] GO:1904707 positive regulation of vascular smooth muscle cell proliferation HTR1B, MMP2, MMP9 2.16746
[BP] GO:0050996 None PPARA, PRKCD, PRKCE 2.16746
[BP] GO:0032768 None CNR1, CNR2, EGFR, HTR2B 2.16358
[BP] GO:0051047 None ACHE, ADORA1, CYP19A1, EGFR, HTR2B, MMP12, PRKCE, SRC, TRPV1 2.1594
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, CNR1, EGFR, PIK3CB, PTGS2 2.15865
[BP] GO:0072593 reactive oxygen species metabolic process BCL2, CYP1A1, CYP1A2, CYP1B1, EGFR 2.15213
[BP] GO:0009653 anatomical structure morphogenesis APP, AR, AXL, BCL2, CA2, CA9, CACNA1C, CYP1B1, EGFR, ESR1, HTR2B, INSR, MET, MMP2, RELA, SMAD3, SRC, TEK 2.13946
[BP] GO:2001237 negative regulation of extrinsic apoptotic signaling pathway AR, BCL2, HSPA1A, RELA, SRC 2.1336
[BP] GO:0045785 positive regulation of cell adhesion ALOX15, KDR, MAP3K7, PIK3CA, PRKCA, PRKCE, SMAD3, SRC, TEK 2.122
[BP] GO:1901617 organic hydroxy compound biosynthetic process AKR1B1, AKR1C3, ALOX15, CYP19A1, HSD17B3, TYR 2.12147
[BP] GO:2000209 regulation of anoikis BCL2, PIK3CA, SRC 2.1159
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.1159
[BP] GO:1903391 regulation of adherens junction organization KDR, SMAD3, SRC, TEK 2.11081
[BP] GO:0001889 liver development CSNK2A1, EGFR, PIK3CA, RELA, SMAD3 2.09902
[BP] GO:0006810 None ACHE, ADORA1, AKR1C3, ALOX15, ALOX5, APP, AR, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, F10, FABP3, HSPA1A, HTR1B, HTR2A, HTR2B, HTR2C, KIT, MMP12, MMP9, PPARA, PRKCB, PRKCD, PRKCE, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SRC, TRPV1, XDH 2.0869
[BP] GO:0048863 stem cell differentiation BCHE, ESR1, HTR2B, KIT 2.08406
[BP] GO:0051222 positive regulation of protein transport ACHE, APP, EGFR, HTR2B, MMP12, PRKCD, PRKCE, PTGS2, SMAD3, SRC 2.08406
[BP] GO:0010565 None AKR1C3, CNR1, FABP3, PPARA, PRKCE, PTGS2 2.08406
[BP] GO:0010811 positive regulation of cell-substrate adhesion ALOX15, KDR, PRKCE, SMAD3, TEK 2.08354
[BP] GO:0002376 immune system process ALOX5, APP, AXL, BCL2, CACNA1C, CNR2, FLT3, FUT7, HSPA1A, IGF1R, KIT, MAP3K7, MMP1, MMP9, PIK3CA, PIK3CB, PRKCB, PRKCD, PRKCE, RELA, RORC, SMAD3, SRC, TEK, TRPV1 2.07429
[BP] GO:0051234 None ACHE, ADORA1, AKR1C3, ALOX15, ALOX5, APP, AR, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, EGFR, F10, FABP3, HSPA1A, HTR1B, HTR2A, HTR2B, HTR2C, KIT, MMP12, MMP9, PPARA, PRKCB, PRKCD, PRKCE, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SRC, TRPV1, XDH 2.0713
[BP] GO:0051894 None KDR, SMAD3, TEK 2.0713
[BP] GO:0007202 None EGFR, HTR2A, HTR2B 2.0713
[BP] GO:0061900 None APP, EGFR, TRPV1 2.0713
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.0713
[BP] GO:0001819 positive regulation of cytokine production CYP1B1, HSPA1A, HTR2B, MAP3K7, MMP12, PTGS2, RELA, SMAD3, SRC 2.0713
[BP] GO:0031331 positive regulation of cellular catabolic process HSPA1A, HTR2A, INSR, KDR, MAP3K7, PIK3CB, PPARA, PRKCD, PTPN1 2.0713
[BP] GO:0010641 None F3, SRC 2.0713
[BP] GO:0007598 None F10, F3 2.0713
[BP] GO:0002318 myeloid progenitor cell differentiation FLT3, KIT 2.0713
[BP] GO:0046618 None SLC47A1, SLC47A2 2.0713
[BP] GO:2000116 regulation of cysteine-type endopeptidase activity CSNK2A1, F3, MMP9, PTGS2, SMAD3, SRC, XDH 2.06496
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AKR1C3, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FABP3, FABP4, FUT7, HSPA1A, MAOA, MMP1, MMP12, MMP2, MMP9, PIK3CB, SRC, XDH 2.05669
[BP] GO:1903034 regulation of response to wounding F3, MAP2K1, PRKCA, PRKCD, PRKCE, SMAD3 2.05462
[BP] GO:0045089 positive regulation of innate immune response HSPA1A, MAP3K7, MMP12, MMP2, PRKCD, PRKCE, RELA, SRC 2.04583
[BP] GO:0046328 regulation of JNK cascade APP, DUSP3, EGFR, IGF1R, MAP3K7, PTPN1 2.04198
[BP] GO:0050877 None ADORA1, APP, BCHE, CNR1, CNR2, CYP1B1, EGFR, HTR2A, INSR, KIT, PRKCG, PTGS2, TRPV1, TYR 2.03602
[BP] GO:0050927 None F3, KDR, SMAD3 2.02504
[BP] GO:0045595 regulation of cell differentiation APP, AR, AXL, BCL2, CA2, CNR1, EGFR, HTR2A, HTR2C, KDR, KIT, MAP2K1, PPARA, PRKCA, PRKCB, PTGS2, RELA, RORC, SMAD3, TRPV1, XDH 2.02187
[BP] GO:0006816 None CACNA1C, HTR2A, HTR2B, HTR2C, PRKCB, PRKCE, TRPV1 2.01521
[BP] GO:0046834 lipid phosphorylation EGFR, KIT, MET, PIK3CA, PIK3CB 2.00689
[CC] GO:0005886 plasma membrane ACHE, ADORA1, ADORA3, ALOX15, ALPL, APP, AR, AXL, CA12, CA14, CA2, CA4, CA9, CACNA1C, CNR1, CNR2, CSNK2A1, EGFR, ESR1, F10, F3, FLT3, GLO1, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MMP2, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SMAD3, SRC, TEK, TRPV1 11.6654
[CC] GO:0016020 membrane ACHE, ADORA1, ADORA3, ALOX15, ALOX5, ALPL, APP, AR, AXL, BCHE, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, F10, F3, FLT3, FUT7, GLO1, GPR35, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP2, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SMAD3, SRC, TEK, TRPV1, TYR 9.44051
[CC] GO:0031226 intrinsic component of plasma membrane ADORA1, ADORA3, APP, AXL, CA4, CNR1, CNR2, F10, F3, FLT3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, SLC22A1, SLC22A2, SLC22A3, TEK, TRPV1 8.31629
[CC] GO:0044459 plasma membrane part ADORA1, ADORA3, ALOX15, APP, AXL, CA2, CA4, CA9, CACNA1C, CNR1, CNR2, DUSP3, EGFR, F10, F3, FLT3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, PRKCG, PTGS2, SLC22A1, SLC22A2, SLC22A3, SRC, TEK, TRPV1 7.72144
[CC] GO:0005887 integral component of plasma membrane ADORA1, ADORA3, APP, AXL, CNR1, CNR2, FLT3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, MET, SLC22A1, SLC22A2, SLC22A3, TEK, TRPV1 6.88965
[CC] GO:0044425 membrane part ACHE, ADORA1, ADORA3, ALOX15, ALPL, APP, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CACNA1C, CNR1, CNR2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, F10, F3, FLT3, FUT7, GPR35, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MAOA, MET, PIK3CA, PIK3CB, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SRC, TEK, TRPV1, TYR 5.98302
[CC] GO:0005641 nuclear envelope lumen ALOX5, APP, BCHE, PTGES 5.28851
[CC] GO:0005783 None ADORA1, APEX1, APP, BCL2, CA4, CYP19A1, FLT3, HSD17B3, HSPA1A, HTR5A, KDR, MAP2K1, PRKCA, PRKCD, PRKCE, PTGS2, PTPN1, XDH 3.78076
[CC] GO:0048471 perinuclear region of cytoplasm ACHE, AKR1B1, APEX1, APP, CA4, EGFR, HSPA1A, PRKCA, PRKCD, PRKCE, PRKCG, PTGES, SRC, TYR 3.29624
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, APEX1, APP, AR, AURKB, BCHE, BCL2, CA1, CA2, CA4, CA7, CACNA1C, CBR1, CDC25B, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, F10, FABP3, FABP4, FLT3, FUT7, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HSPA1A, HTR2A, HTR4, HTR5A, INSR, KDR, KIT, MAOA, MAP2K1, MAP3K7, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, RELA, SMAD3, SRC, TOP1, TOP2A, TRPV1, TYR, XDH 3.22254
[CC] GO:0009330 None TOP1, TOP2A 2.914
[CC] GO:0045121 membrane raft APP, CNR1, EGFR, HTR2A, INSR, KDR, PTGS2, SRC, TEK 2.90757
[CC] GO:0031224 None ACHE, ADORA1, ADORA3, ALPL, APP, AXL, CA12, CA14, CA4, CA9, CACNA1C, CNR1, CNR2, EGFR, ESR1, F10, F3, FLT3, FUT7, GPR35, HSD11B1, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MAOA, MET, PTGES, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, TEK, TRPV1, TYR 2.89264
[CC] GO:0098857 membrane microdomain APP, CNR1, EGFR, HTR2A, INSR, KDR, PTGS2, SRC, TEK 2.88782
[CC] GO:0044464 cell part ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, APEX1, APP, AR, AURKB, AXL, BCHE, BCL2, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CBR1, CDC25B, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, FUT7, GLO1, GPR35, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, RELA, RORC, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SMAD3, SRC, TEK, TOP1, TOP2A, TRPV1, TYR, XDH 2.72759
[CC] GO:0016323 basolateral plasma membrane ADORA1, CA2, CA4, CA9, EGFR, SLC22A1, TEK 2.59703
[CC] GO:0098589 membrane region APP, CNR1, EGFR, HTR2A, INSR, KDR, PTGS2, SRC, TEK 2.36654
[CC] GO:0031233 None CA4, F10, F3 2.26689
[CC] GO:0044432 endoplasmic reticulum part APP, BCHE, BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, F10, FLT3, HSD11B1, HSD11B2, HSD17B2, HSD17B3, PTGES, PTGS1, PTGS2, PTPN1 2.23999
[CC] GO:0016021 None ADORA1, ADORA3, ALPL, APP, AXL, CA12, CA14, CA9, CACNA1C, CNR1, CNR2, EGFR, ESR1, F3, FLT3, FUT7, GPR35, HSD11B1, HSD17B2, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MAOA, MET, PTGES, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, TEK, TRPV1, TYR 2.22305
[CC] GO:0098590 plasma membrane region ADORA1, CA2, CA4, CA9, CNR1, EGFR, HTR2A, INSR, MET, PRKCG, PTGS2, SLC22A1, SRC, TEK, TRPV1 2.13037
[MF] GO:0043176 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 15.6302
[MF] GO:0051378 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 15.6302
[MF] GO:0043167 ion binding ACHE, ALOX15, ALOX5, ALPL, APEX1, APP, AR, AURKB, AXL, BCHE, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, GLO1, HSD17B1, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, RELA, RORC, SMAD3, SRC, TEK, TOP1, TOP2A, TRPV1, TYR, XDH 15.6302
[MF] GO:0004993 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 15.6302
[MF] GO:0099589 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 15.6302
[MF] GO:0099528 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 13.2258
[MF] GO:0008144 drug binding ACHE, AURKB, AXL, CNR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, FLT3, HSPA1A, HTR1B, HTR2A, HTR2B, HTR2C, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP1, TOP2A, TRPV1 11.9353
[MF] GO:0042165 neurotransmitter binding ACHE, BCHE, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 11.6726
[MF] GO:0003824 catalytic activity ACHE, ADORA1, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, APEX1, AURKB, AXL, BCHE, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, F10, F3, FLT3, FUT7, GLO1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HSPA1A, IGF1R, INSR, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, SRC, TEK, TOP1, TOP2A, TYR, XDH 11.5913
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, APP, AR, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PIM1, PPARA, PRKCA, PRKCB, PRKCG, PTPN1, RORC, SMAD3, TYR, XDH 11.5913
[MF] GO:0008227 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 11.2586
[MF] GO:0070405 ammonium ion binding ACHE, BCHE, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7 10.0964
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, APEX1, APP, AR, AURKB, BCHE, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F10, GLO1, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, KIT, MAP3K7, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SMAD3, TOP2A, TRPV1, TYR, XDH 10.0311
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP1 9.67498
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.61094
[MF] GO:0004871 signal transducer activity ADORA1, ADORA3, AR, AXL, CNR1, CNR2, EGFR, ESR1, F3, FLT3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, PPARA, PRKCE, RORC, SMAD3, TEK, TRPV1 9.29197
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP1 9.00351
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AR, AXL, CNR1, CNR2, EGFR, ESR1, F3, FLT3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, PPARA, RORC, TEK, TRPV1 8.97674
[MF] GO:0030594 None HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 8.37467
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP1 8.28991
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, APEX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, MAOA, NQO2, PTGS1, PTGS2, TYR, XDH 8.05196
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, TEK 8.00847
[MF] GO:0004872 receptor activity ADORA1, ADORA3, AR, AXL, CNR1, CNR2, EGFR, ESR1, F3, FLT3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, PPARA, RORC, TEK, TRPV1 7.77572
[MF] GO:0060089 molecular transducer activity ADORA1, ADORA3, AR, AXL, CNR1, CNR2, EGFR, ESR1, F3, FLT3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, PPARA, RORC, TEK, TRPV1 7.47277
[MF] GO:0004713 protein tyrosine kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MAP2K1, MET, PRKCD, SRC, TEK 7.3159
[MF] GO:0099600 transmembrane receptor activity ADORA1, ADORA3, AXL, CNR1, CNR2, EGFR, F3, FLT3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, TEK, TRPV1 7.2343
[MF] GO:0004888 transmembrane signaling receptor activity ADORA1, ADORA3, AXL, CNR1, CNR2, EGFR, F3, FLT3, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MET, TEK, TRPV1 7.2343
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MET, TEK 7.17452
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, EGFR, FLT3, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP1 7.025
[MF] GO:0043560 insulin receptor substrate binding IGF1R, INSR, PIK3CA, PIK3CB, PRKCD 6.59125
[MF] GO:0008270 zinc ion binding AR, CA1, CA12, CA2, CA4, CA7, CA9, ESR1, GLO1, MMP1, MMP12, MMP2, MMP9, NQO2, PPARA, PRKCA, PRKCB, PRKCG, PTPN1, RORC, SMAD3 6.59125
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AKR1C3, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, XDH 6.36773
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1C3, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 6.14274
[MF] GO:0016835 carbon-oxygen lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.0917
[MF] GO:0016229 steroid dehydrogenase activity AKR1C3, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 5.97743
[MF] GO:0043168 anion binding ALOX15, APP, AURKB, AXL, CSNK2A1, EGFR, F10, F3, FABP3, FABP4, FLT3, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, RELA, SRC, TEK, TOP1, TOP2A, TRPV1, XDH 5.96187
[MF] GO:0005524 ATP binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP1, TOP2A, TRPV1 5.89053
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, AKR1C3, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3 5.76979
[MF] GO:0004697 None PRKCA, PRKCB, PRKCD, PRKCE, PRKCG 5.74053
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.73375
[MF] GO:0042562 hormone binding ACHE, AR, EGFR, HSD17B1, IGF1R, INSR, NQO2, SHBG 5.71609
[MF] GO:0032559 adenyl ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP1, TOP2A, TRPV1 5.70938
[MF] GO:0030554 adenyl nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP1, TOP2A, TRPV1 5.65644
[MF] GO:0036094 small molecule binding ADORA1, AURKB, AXL, CSNK2A1, EGFR, FABP3, FABP4, FLT3, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP1, TOP2A, TRPV1, XDH 5.14532
[MF] GO:0004716 signal transducer, downstream of receptor, with protein tyrosine kinase activity EGFR, INSR, KDR, KIT 5.06059
[MF] GO:0000166 nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP1, TOP2A, TRPV1, XDH 5.03353
[MF] GO:1901265 nucleoside phosphate binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSD11B2, HSD17B1, HSPA1A, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP1, TOP2A, TRPV1, XDH 5.03057
[MF] GO:0004674 protein serine/threonine kinase activity AURKB, CSNK2A1, EGFR, MAP2K1, MAP3K7, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, TOP1 4.91327
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, APEX1, APP, AR, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F10, GLO1, KIT, MAP3K7, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RORC, SMAD3, TOP2A, TRPV1, TYR, XDH 4.80392
[MF] GO:0097159 organic cyclic compound binding ADORA1, APEX1, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FLT3, HSD11B2, HSD17B1, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RELA, RORC, SHBG, SMAD3, SRC, TEK, TOP1, TOP2A, TRPV1, XDH 4.77873
[MF] GO:1901363 heterocyclic compound binding ADORA1, APEX1, APP, AR, AURKB, AXL, BCL2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, EGFR, ESR1, FLT3, HSD11B2, HSD17B1, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MMP12, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGS1, PTGS2, PTPN1, RELA, RORC, SMAD3, SRC, TEK, TOP1, TOP2A, TRPV1, XDH 4.58403
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CDC25B, CSNK2A1, DUSP3, EGFR, F10, F3, FLT3, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NUAK1, PIK3CA, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTPN1, SRC, TEK, TOP1 4.48168
[MF] GO:0004698 None PRKCA, PRKCB, PRKCG 4.35657
[MF] GO:0016829 lyase activity APEX1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, GLO1 4.31726
[MF] GO:0035639 purine ribonucleoside triphosphate binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP1, TOP2A, TRPV1 4.2686
[MF] GO:0032555 purine ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP1, TOP2A, TRPV1 4.08245
[MF] GO:0017076 purine nucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP1, TOP2A, TRPV1 4.03636
[MF] GO:0032553 ribonucleotide binding AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP1, TOP2A, TRPV1 4.02691
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, TYR 3.90382
[MF] GO:0097367 carbohydrate derivative binding ADORA1, APP, AURKB, AXL, CSNK2A1, EGFR, FLT3, HSPA1A, IGF1R, INSR, KDR, KIT, MAP2K1, MAP3K7, MET, NUAK1, PIK3CA, PIK3CB, PIM1, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, SRC, TEK, TOP1, TOP2A, TRPV1 3.81711
[MF] GO:0005329 None SLC22A1, SLC22A2, SLC22A3 3.73923
[MF] GO:0047035 testosterone dehydrogenase (NAD+) activity AKR1C3, HSD17B2, HSD17B3 3.73923
[MF] GO:0005057 signal transducer activity, downstream of receptor EGFR, INSR, KDR, KIT, MAP2K1, MAP3K7, SMAD3 3.59759
[MF] GO:0044877 macromolecular complex binding ACHE, ADORA1, APEX1, CSNK2A1, EGFR, FLT3, HTR2A, IGF1R, INSR, KDR, MMP12, MMP9, PIM1, PPARA, PTPN1, RELA, SMAD3, SRC 3.52979
[MF] GO:0032403 protein complex binding ACHE, ADORA1, APEX1, EGFR, FLT3, HTR2A, IGF1R, INSR, KDR, MMP12, MMP9, PPARA, PTPN1, RELA, SMAD3, SRC 3.52979
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, SRC 3.4822
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.4475
[MF] GO:0005496 steroid binding AR, ESR1, HSD11B2, HSD17B1, RORC, SHBG 3.41869
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2, SRC 3.292
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.25203
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, HSD11B2, HSD17B1, NQO2, PTGES, PTGS1, PTGS2, SRC, XDH 3.2375
[MF] GO:0004497 monooxygenase activity AKR1C3, CYP19A1, CYP1A1, CYP1A2, CYP1B1, TYR 3.20269
[MF] GO:0008504 None SLC22A1, SLC22A2, SLC22A3 3.20269
[MF] GO:0015651 None SLC22A1, SLC22A2, SLC22A3 3.20269
[MF] GO:0042802 identical protein binding ACHE, APP, BCHE, BCL2, CSNK2A1, EGFR, ESR1, FLT3, IGF1R, KDR, KIT, MAP3K7, MET, MMP9, NQO2, PTGS2, RELA, SLC22A1, SMAD3, TOP2A, TRPV1, TYR, XDH 3.14036
[MF] GO:0008289 lipid binding ALOX15, AR, AXL, ESR1, F10, F3, FABP3, FABP4, HSD11B2, HSD17B1, PPARA, RORC, SHBG, TRPV1 3.11001
[MF] GO:0004930 None ADORA1, ADORA3, CNR1, CNR2, GPR35, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7 3.09062
[MF] GO:0009931 None PRKCA, PRKCB, PRKCG 2.96159
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, XDH 2.94702
[MF] GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity EGFR, KIT, MET, PIK3CA, PIK3CB 2.914
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.914
[MF] GO:0045550 None AKR1B10, AKR1C3 2.914
[MF] GO:0003990 acetylcholinesterase activity ACHE, BCHE 2.914
[MF] GO:0003845 None HSD11B1, HSD11B2 2.914
[MF] GO:0035403 None PRKCA, PRKCB 2.914
[MF] GO:0071886 None HTR2A, HTR2C 2.914
[MF] GO:0019899 enzyme binding APP, AR, AURKB, BCHE, BCL2, CDC25B, CYP1A1, CYP1A2, DUSP3, EGFR, ESR1, F3, HSPA1A, KIT, MET, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PTGS2, PTPN1, RELA, SMAD3, SRC, TEK, TOP2A 2.90785
[MF] GO:0010857 None PRKCA, PRKCB, PRKCG 2.87517
[MF] GO:0052813 phosphatidylinositol bisphosphate kinase activity EGFR, KIT, MET, PIK3CA, PIK3CB 2.84332
[MF] GO:0003674 molecular_function ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, AKR1C3, ALOX15, ALOX5, ALPL, APEX1, APP, AR, AURKB, AXL, BCHE, BCL2, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CACNA1C, CBR1, CDC25B, CNR1, CNR2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, DUSP3, EGFR, ESR1, F10, F3, FABP3, FABP4, FLT3, FUT7, GLO1, GPR35, HSD11B1, HSD11B2, HSD17B1, HSD17B2, HSD17B3, HSPA1A, HTR1A, HTR1B, HTR1D, HTR1E, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, IGF1R, INSR, KDR, KIT, MAOA, MAP2K1, MAP3K7, MET, MMP1, MMP12, MMP2, MMP9, NQO2, NUAK1, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PRKCB, PRKCD, PRKCE, PRKCG, PTGES, PTGS1, PTGS2, PTPN1, RELA, RORC, SHBG, SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2, SMAD3, SRC, TEK, TOP1, TOP2A, TRPV1, TYR, XDH 2.77085
[MF] GO:0035004 phosphatidylinositol 3-kinase activity EGFR, KIT, MET, PIK3CA, PIK3CB 2.70589
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.5123
[MF] GO:0015307 None SLC47A1, SLC47A2 2.5123
[MF] GO:1901375 None SLC22A1, SLC22A2 2.5123
[MF] GO:0047718 None AKR1B10, AKR1C3 2.5123
[MF] GO:0004949 None CNR1, CNR2 2.5123
[MF] GO:0005333 None SLC22A1, SLC22A2 2.5123
[MF] GO:0047045 None AKR1C3, HSD17B3 2.5123
[MF] GO:0005277 None SLC22A1, SLC22A2 2.5123
[MF] GO:0004104 cholinesterase activity ACHE, BCHE 2.5123
[MF] GO:0008513 None SLC22A1, SLC22A2 2.5123
[MF] GO:0004699 None PRKCD, PRKCE 2.5123
[MF] GO:0016903 None AKR1B1, AKR1B10, AKR1C3, XDH 2.48801
[MF] GO:0035173 histone kinase activity AURKB, PRKCA, PRKCB 2.46148
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.45432
[MF] GO:0035258 None ESR1, FLT3, PRKCB, SMAD3, SRC 2.40805
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding AR, ESR1, PPARA, RORC 2.32715
[MF] GO:0004879 nuclear receptor activity AR, ESR1, PPARA, RORC 2.32715
[MF] GO:0015238 None SLC22A1, SLC22A2, SLC22A3, SLC47A1, SLC47A2 2.28624
[MF] GO:0005497 None AR, SHBG 2.24975
[MF] GO:0051425 None APP, INSR 2.24975
[MF] GO:0019900 None AURKB, CDC25B, DUSP3, EGFR, ESR1, PRKCB, PRKCD, PTPN1, RELA, SMAD3, SRC, TOP2A 2.1547
[MF] GO:0019902 phosphatase binding BCL2, EGFR, MET, PPARA, PTPN1, SMAD3 2.09582
[MF] GO:0019901 None CDC25B, DUSP3, EGFR, ESR1, PRKCB, PRKCD, PTPN1, RELA, SMAD3, SRC, TOP2A 2.0713
[MF] GO:0015101 None SLC22A1, SLC22A2, SLC22A3 2.0713
[MF] GO:0043559 insulin binding IGF1R, INSR 2.0713
[MF] GO:0003707 steroid hormone receptor activity AR, ESR1, PPARA, RORC 2.06677
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, NQO2, XDH 2.05669
[MF] GO:0008134 transcription factor binding APEX1, AR, BCL2, ESR1, FLT3, PIM1, PPARA, PRKCB, RELA, SMAD3, SRC 2.00598


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Serotonergic synapse_Homo sapiens_hsa04726 PRKCG, APP, MAP2K1, HTR1E, PRKCB, MAOA, ALOX15, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, PRKCA, CACNA1C, HTR2A, PTGS2, HTR5A, HTR4, PTGS1, HTR6, HTR7, ALOX5 26.0913
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, INSR, HSD17B1, HSD17B2, CYP1A1, AKR1C3, CYP1B1, PTGS2, CYP19A1, IGF1R 11.3009
Pathways in cancer_Homo sapiens_hsa05200 PRKCG, MAP2K1, SMAD3, PRKCB, FLT3, MMP1, MMP2, PRKCA, PIK3CB, PTGS2, MMP9, EGFR, RELA, IGF1R, AR, PIK3CA, KIT, BCL2, MET 11.2501
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PRKCG, PIK3CA, PRKCB, SRC, PRKCE, PRKCD, HTR2B, HTR2C, PRKCA, PIK3CB, TRPV1, HTR2A 11.2725
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 SMAD3, PIK3CA, PRKCB, MMP2, PRKCE, PRKCD, BCL2, PIM1, PRKCA, PIK3CB, F3, RELA 11.2501
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 HTR1E, GPR35, HTR1D, HTR2B, HTR1A, HTR1B, HTR2C, TRPV1, HTR2A, HTR5A, HTR4, HTR6, HTR7, CNR2, CNR1, ADORA3, ADORA1 11.3009
Rap1 signaling pathway_Homo sapiens_hsa04015 PRKCG, MAP2K1, PRKCB, SRC, INSR, PRKCA, PIK3CB, EGFR, IGF1R, PIK3CA, CNR1, KIT, KDR, TEK, MET 11.18
Ras signaling pathway_Homo sapiens_hsa04014 PRKCG, MAP2K1, PRKCB, INSR, PRKCA, PIK3CB, EGFR, RELA, IGF1R, HTR7, PIK3CA, KIT, KDR, TEK, MET 10.8142
HIF-1 signaling pathway_Homo sapiens_hsa04066 PRKCG, MAP2K1, PIK3CA, PRKCB, INSR, BCL2, PRKCA, TEK, PIK3CB, EGFR, RELA, IGF1R 11.2501
Proteoglycans in cancer_Homo sapiens_hsa05205 PRKCG, MAP2K1, PRKCB, SRC, MMP2, PRKCA, PIK3CB, MMP9, ESR1, EGFR, IGF1R, PIK3CA, KDR, MET 10.3601
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, HSD17B3, AKR1C3, CYP1B1, CYP19A1 11.0871
cAMP signaling pathway_Homo sapiens_hsa04024 MAP2K1, HTR1E, HTR1D, HTR1A, HTR1B, CACNA1C, PIK3CB, HTR4, RELA, HTR6, PIK3CA, ADORA1, PPARA 9.3602
VEGF signaling pathway_Homo sapiens_hsa04370 PRKCG, MAP2K1, PIK3CA, PRKCB, SRC, KDR, PRKCA, PIK3CB, PTGS2 9.4096
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PRKCG, MAP2K1, PIK3CA, PRKCB, ADORA3, PRKCE, BCL2, ADORA1, PRKCA, PIK3CB, RELA 9.3726
Estrogen signaling pathway_Homo sapiens_hsa04915 MAP2K1, PIK3CA, SRC, MMP2, PRKCD, PIK3CB, MMP9, ESR1, EGFR, HSPA1A 8.9382
Choline metabolism in cancer_Homo sapiens_hsa05231 PRKCG, SLC22A3, MAP2K1, PIK3CA, PRKCB, SLC22A2, SLC22A1, PRKCA, PIK3CB, EGFR 8.8775
Calcium signaling pathway_Homo sapiens_hsa04020 PRKCG, HTR6, HTR7, PRKCB, HTR2B, HTR2C, PRKCA, CACNA1C, HTR2A, HTR5A, HTR4, EGFR 8.7908
Hepatitis B_Homo sapiens_hsa05161 PRKCG, MAP2K1, SMAD3, PIK3CA, PRKCB, SRC, BCL2, PRKCA, PIK3CB, MMP9, RELA 8.6015
MicroRNAs in cancer_Homo sapiens_hsa05206 PRKCG, MAP2K1, PRKCB, PRKCE, PRKCA, PTGS2, MMP9, EGFR, CDC25B, PIK3CA, BCL2, PIM1, CYP1B1, MET 8.3986
Focal adhesion_Homo sapiens_hsa04510 PRKCG, MAP2K1, PIK3CA, PRKCB, SRC, KDR, BCL2, PRKCA, PIK3CB, MET, EGFR, IGF1R 8.2763
Adherens junction_Homo sapiens_hsa04520 PTPN1, SMAD3, CSNK2A1, SRC, INSR, MAP3K7, MET, EGFR, IGF1R 8.7908
Cholinergic synapse_Homo sapiens_hsa04725 PRKCG, ACHE, MAP2K1, PIK3CA, PRKCB, BCL2, PRKCA, CACNA1C, PIK3CB 7.3557
Glioma_Homo sapiens_hsa05214 PRKCG, MAP2K1, PIK3CA, PRKCB, PRKCA, PIK3CB, EGFR, IGF1R 7.9201
Gap junction_Homo sapiens_hsa04540 PRKCG, MAP2K1, PRKCB, SRC, HTR2B, HTR2C, PRKCA, HTR2A, EGFR 8.1898
Oxytocin signaling pathway_Homo sapiens_hsa04921 PRKCG, MAP2K1, PIK3CA, PRKCB, SRC, PRKCA, CACNA1C, PIK3CB, PTGS2, EGFR 7.1832
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, PRKCB, INSR, PRKCE, PRKCD, PIK3CB, PPARA, RELA 7.4093
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 MAP2K1, INSR, PRKCA, PIK3CB, EGFR, RELA, IGF1R, PIK3CA, KIT, KDR, BCL2, TEK, MET 6.8771
ErbB signaling pathway_Homo sapiens_hsa04012 PRKCG, MAP2K1, PIK3CA, PRKCB, SRC, PRKCA, PIK3CB, EGFR 6.991
Prostate cancer_Homo sapiens_hsa05215 AR, MAP2K1, PIK3CA, BCL2, PIK3CB, EGFR, RELA, IGF1R 6.9393
GnRH signaling pathway_Homo sapiens_hsa04912 MAP2K1, PRKCB, SRC, MMP2, PRKCD, PRKCA, CACNA1C, EGFR 6.8771
Non-small cell lung cancer_Homo sapiens_hsa05223 PRKCG, MAP2K1, PIK3CA, PRKCB, PRKCA, PIK3CB, EGFR 7.0075
MAPK signaling pathway_Homo sapiens_hsa04010 PRKCG, MAP2K1, DUSP3, PRKCB, PRKCA, CACNA1C, MAP3K7, EGFR, RELA, CDC25B, HSPA1A 6.3687
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PRKCG, MAP2K1, PIK3CA, PRKCB, PRKCE, PRKCD, PRKCA, PIK3CB 6.8256
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, INSR, ADORA1, PIK3CB, PTGS2, PTGS1 7.0075
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PRKCG, HSD11B2, PIK3CA, PRKCB, INSR, PRKCA, PIK3CB 8.0576
Acute myeloid leukemia_Homo sapiens_hsa05221 MAP2K1, PIK3CA, FLT3, KIT, PIM1, PIK3CB, RELA 6.9805
Metabolic pathways_Homo sapiens_hsa01100 CBR1, MAOA, ALOX15, HSD17B3, AKR1C3, AKR1B1, PTGS2, TYR, CYP19A1, PTGS1, HSD11B1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH, PTGES 5.2518
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 10.5763
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PRKCG, MAP2K1, PIK3CA, PRKCB, SRC, PRKCA, PIK3CB, ESR1 6.0826
Central carbon metabolism in cancer_Homo sapiens_hsa05230 MAP2K1, PIK3CA, FLT3, KIT, PIK3CB, MET, EGFR 6.5564
TNF signaling pathway_Homo sapiens_hsa04668 MAP2K1, PIK3CA, PIK3CB, PTGS2, MMP9, MAP3K7, RELA 5.1458
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 MAP2K1, PIK3CA, ADORA3, INSR, PRKCE, ADORA1, CACNA1C, PIK3CB 4.9935
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, AKR1C3, PTGS2, PTGES, PTGS1 6.7833
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB, MAP3K7, RELA, HSPA1A 4.9872
Vascular smooth muscle contraction_Homo sapiens_hsa04270 PRKCG, MAP2K1, PRKCB, PRKCE, PRKCD, PRKCA, CACNA1C 4.9469
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PRKCG, PIK3CA, PRKCB, MMP2, PRKCA, PIK3CB, MMP9 4.9872
Pancreatic cancer_Homo sapiens_hsa05212 MAP2K1, SMAD3, PIK3CA, PIK3CB, EGFR, RELA 5.2803
FoxO signaling pathway_Homo sapiens_hsa04068 MAP2K1, SMAD3, PIK3CA, INSR, PIK3CB, EGFR, IGF1R 4.6672
Phospholipase D signaling pathway_Homo sapiens_hsa04072 MAP2K1, PIK3CA, INSR, KIT, PRKCA, PIK3CB, EGFR 4.4643
Melanoma_Homo sapiens_hsa05218 MAP2K1, PIK3CA, PIK3CB, MET, EGFR, IGF1R 5.121
Prolactin signaling pathway_Homo sapiens_hsa04917 MAP2K1, PIK3CA, SRC, PIK3CB, ESR1, RELA 5.0944
Tight junction_Homo sapiens_hsa04530 PRKCG, CSNK2A1, PRKCB, SRC, PRKCE, PRKCD, PRKCA 4.5491
Melanogenesis_Homo sapiens_hsa04916 PRKCG, MAP2K1, PRKCB, KIT, PRKCA, TYR 4.3542
Amoebiasis_Homo sapiens_hsa05146 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB, RELA 4.3542
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PRKCG, PRKCB, CNR1, PRKCA, CACNA1C, PTGS2 4.3369
Influenza A_Homo sapiens_hsa05164 MAP2K1, PIK3CA, PRKCB, PRKCA, PIK3CB, RELA, HSPA1A 3.9884
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, PRKCB, BCL2, PTGS2, MAP3K7, RELA 4.5126
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1, PTGS2 4.806
Endocytosis_Homo sapiens_hsa04144 SMAD3, SRC, KIT, KDR, MET, EGFR, IGF1R, HSPA1A 3.7948
Neurotrophin signaling pathway_Homo sapiens_hsa04722 MAP2K1, PIK3CA, PRKCD, BCL2, PIK3CB, RELA 3.9805
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, INSR, PRKCE, PRKCD, CACNA1C, PIK3CB 6.0962
Chemokine signaling pathway_Homo sapiens_hsa04062 MAP2K1, PIK3CA, PRKCB, SRC, PRKCD, PIK3CB, RELA 3.8431
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB, MAP3K7, RELA, HSPA1A 3.6728
Measles_Homo sapiens_hsa05162 CSNK2A1, PIK3CA, PIK3CB, MAP3K7, RELA, HSPA1A 3.7238
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PRKCG, MAP2K1, PIK3CA, PRKCB, PRKCA, PIK3CB 3.7359
Bladder cancer_Homo sapiens_hsa05219 MAP2K1, SRC, MMP1, MMP2, MMP9, EGFR 6.4977
Purine metabolism_Homo sapiens_hsa00230 XDH 0.2203
Wnt signaling pathway_Homo sapiens_hsa04310 PRKCG, SMAD3, CSNK2A1, PRKCB, PRKCA, MAP3K7 3.6421
Hippo signaling pathway_Homo sapiens_hsa04390 SMAD3 0.2565
Spliceosome_Homo sapiens_hsa03040 HSPA1A 0.293
Axon guidance_Homo sapiens_hsa04360 MET 0.307
B cell receptor signaling pathway_Homo sapiens_hsa04662 MAP2K1, PIK3CA, PRKCB, PIK3CB, RELA 3.9805
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.3777
Chronic myeloid leukemia_Homo sapiens_hsa05220 MAP2K1, SMAD3, PIK3CA, PIK3CB, RELA 3.9805
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.3957
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2, HSPA1A 0.6017
Taste transduction_Homo sapiens_hsa04742 HTR1E, HTR1D, HTR1A, HTR1B, CACNA1C 3.7421
Alcoholism_Homo sapiens_hsa05034 MAP2K1, MAOA 0.5784
Alzheimer's disease_Homo sapiens_hsa05010 APP, CACNA1C 0.6028
mTOR signaling pathway_Homo sapiens_hsa04150 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB 4.3369
Long-term depression_Homo sapiens_hsa04730 PRKCG, MAP2K1, PRKCB, PRKCA, IGF1R 4.3369
Dilated cardiomyopathy_Homo sapiens_hsa05414 CACNA1C 0.4116
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 PRKCG, PRKCB, PRKCE, PRKCA, CACNA1C 3.787
TGF-beta signaling pathway_Homo sapiens_hsa04350 SMAD3 0.4281
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, INSR, PIK3CB, IGF1R, HSPA1A 4.2131
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.4131
Salmonella infection_Homo sapiens_hsa05132 RELA 0.4224
Long-term potentiation_Homo sapiens_hsa04720 PRKCG, MAP2K1, PRKCB, PRKCA, CACNA1C 4.1546
Amphetamine addiction_Homo sapiens_hsa05031 PRKCG, PRKCB, MAOA, PRKCA, CACNA1C 4.1294
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 MAP2K1, PIK3CA, PIK3CB, CDC25B, IGF1R 3.4593
Peroxisome_Homo sapiens_hsa04146 XDH 0.4298
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 MAP2K1, PIK3CA, PIK3CB, MAP3K7, RELA 3.3096
Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 CACNA1C 0.4298
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, INSR, PIK3CB, RELA, IGF1R 3.5291
Cardiac muscle contraction_Homo sapiens_hsa04260 CACNA1C 0.4466
T cell receptor signaling pathway_Homo sapiens_hsa04660 MAP2K1, PIK3CA, PIK3CB, MAP3K7, RELA 3.3433
Antigen processing and presentation_Homo sapiens_hsa04612 HSPA1A 0.4487
Pertussis_Homo sapiens_hsa05133 RELA 0.4554
Cell cycle_Homo sapiens_hsa04110 SMAD3, CDC25B 0.7844
Colorectal cancer_Homo sapiens_hsa05210 MAP2K1, SMAD3, PIK3CA, BCL2, PIK3CB 4.2738
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, INSR, PIK3CB, MAP3K7, IGF1R 3.0236
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1, MAP3K7, RELA 1.0404
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PRKCG, PIK3CA, PRKCB, PRKCA, PIK3CB 3.4593
HTLV-I infection_Homo sapiens_hsa05166 SMAD3, PIK3CA, PIK3CB, RELA 1.2106
Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 CACNA1C 0.4578
Apoptosis_Homo sapiens_hsa04210 MAP2K1, PIK3CA, BCL2, PIK3CB, RELA 2.8242
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2, RELA 1.074
Osteoclast differentiation_Homo sapiens_hsa04380 MAP2K1, PIK3CA, PIK3CB, MAP3K7, RELA 2.9179
Dopaminergic synapse_Homo sapiens_hsa04728 PRKCG, PRKCB, MAOA, PRKCA, CACNA1C 2.9543
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, BCL2, PIK3CB, PTGS2, RELA 3.6855
GABAergic synapse_Homo sapiens_hsa04727 PRKCG, PRKCB, SRC, PRKCA, CACNA1C 3.649
Viral carcinogenesis_Homo sapiens_hsa05203 PIK3CA, SRC, PIK3CB, RELA 1.4944
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA, EGFR, RELA 2.9076
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KIT, KDR, MET, EGFR 1.7317
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 MAP2K1, PIK3CA, SRC, PIK3CB, EGFR 2.078
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1 3.9805
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, MAP2K1, PIK3CA, INSR, PIK3CB 2.8339
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 MAP2K1, SMAD3, PIK3CA, PIK3CB, IGF1R 2.8005
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, PIK3CB 1.8398
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PRKCA, CACNA1C, PIK3CB 2.7284
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, INSR, PIK3CB, PPARA, RELA 2.6936
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, RELA, IGF1R 2.3825
Oocyte meiosis_Homo sapiens_hsa04114 AR, MAP2K1, IGF1R 1.4242
Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 RELA 0.5077
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, PIK3CB, PTGS1 2.2102
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1, TEK 1.0017
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3, KIT 1.0156
Glutamatergic synapse_Homo sapiens_hsa04724 PRKCG, PRKCB, PRKCA, CACNA1C 2.3121
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 PRKCA 0.5615
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 SMAD3, PIK3CA, PIK3CB, RELA 2.4489
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 1.0852
Circadian entrainment_Homo sapiens_hsa04713 PRKCG, PRKCB, PRKCA, CACNA1C 2.5814
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.5847
Salivary secretion_Homo sapiens_hsa04970 PRKCG, PRKCB, PRKCA 1.7713
Vibrio cholerae infection_Homo sapiens_hsa05110 PRKCA 0.5847
Pancreatic secretion_Homo sapiens_hsa04972 PRKCG, PRKCB, CA2, PRKCA 2.5686
Morphine addiction_Homo sapiens_hsa05032 PRKCG, PRKCB, ADORA1, PRKCA 2.6465
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOA 0.587
Malaria_Homo sapiens_hsa05144 MET 0.5921
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA, RELA 1.169
Bile secretion_Homo sapiens_hsa04976 CA2, SLC22A1 1.1641
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.1641
RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 MAP3K7, RELA 1.169
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 MAP2K1, PIK3CA, PRKCA, PIK3CB 3.0533
Insulin secretion_Homo sapiens_hsa04911 PRKCG, PRKCB, PRKCA, CACNA1C 2.7445
Leishmaniasis_Homo sapiens_hsa05140 PRKCB, PTGS2, MAP3K7, RELA 2.9543
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 MAOA, CYP1A2 1.1739
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 2.8633
Gastric acid secretion_Homo sapiens_hsa04971 PRKCG, PRKCB, CA2, PRKCA 2.9367
Renin secretion_Homo sapiens_hsa04924 ADORA1, CACNA1C 1.22
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.6084
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1 1.2142
Shigellosis_Homo sapiens_hsa05131 SRC, RELA 1.2142
Renal cell carcinoma_Homo sapiens_hsa05211 MAP2K1, PIK3CA, PIK3CB, MET 3.0933
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET, EGFR, RELA 3.0533
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.0338
Thyroid hormone synthesis_Homo sapiens_hsa04918 PRKCG, PRKCB, PRKCA 2.0188
NOD-like receptor signaling pathway_Homo sapiens_hsa04621 MAP3K7, RELA 1.3049
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.2808
Legionellosis_Homo sapiens_hsa05134 RELA, HSPA1A 1.33
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOA 0.66
Pyruvate metabolism_Homo sapiens_hsa00620 GLO1 0.66
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 SMAD3, RORC, RELA 2.1184
Endometrial cancer_Homo sapiens_hsa05213 MAP2K1, PIK3CA, PIK3CB, EGFR 3.4645
Thyroid cancer_Homo sapiens_hsa05216 MAP2K1 0.7739
Cocaine addiction_Homo sapiens_hsa05030 MAOA, RELA 1.4194
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.7528
Base excision repair_Homo sapiens_hsa03410 APEX1 0.7305
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 PRKCG, PRKCB, PRKCA, ESR1 3.6265
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.8097
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.763
Tryptophan metabolism_Homo sapiens_hsa00380 MAOA, CYP1A2, CYP1A1, CYP1B1 3.8431
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.7972
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PRKCB, PIK3CB 2.555
Prion diseases_Homo sapiens_hsa05020 MAP2K1, HSPA1A 1.6815
Histidine metabolism_Homo sapiens_hsa00340 MAOA 0.8392
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.7929
Dorso-ventral axis formation_Homo sapiens_hsa04320 MAP2K1, EGFR 1.871
Tyrosine metabolism_Homo sapiens_hsa00350 MAOA, TYR 1.6815
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.7459
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.6615
African trypanosomiasis_Homo sapiens_hsa05143 PRKCG, PRKCB, PRKCA 2.8339
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 1.8179
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOA 0.9784
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.0037
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.0478
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.2541


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)