TCM Prescription: Added Flavor DFZ Heat Clearing Decoction



Prescription Description
Prescription IDTCMF2434
Pinyin NameJia Wei Di Fu Zi Tang
Chinese Name加味地肤子汤
English NameAdded Flavor DFZ Heat Clearing Decoction
Function Description
IndicationsNone
Disease ICD-11 Category
Human Tissues Associated with Indication
ReferenceChinese Classical Prescriptions
Reference Book/linkISBN 7-5023-3930-2
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH448 Fructus kochiae 地肤子 TCMH448
TCMH2134 Smilax glabra 土茯苓 TCMH2134 CPBOL4081-11
TCMH228 Bupleurum chinense 柴胡 TCMH228 ITSAM2218-14
TCMH797 Sargassum 海藻 TCMH797
TCMH986 Scutellaria baicalensis 黄芩 TCMH986 ITSAP4211-14
TCMH1706 Dianthus superbus 瞿麦 TCMH1706 ITSAJ4556-14
TCMH2671 Polyporus umbellatus 猪苓 TCMH2671 NOBAS3307-16
TCMH2624 Anemarrhena asphodeloides 知母 TCMH2624 GBVA3255-11, GBVU1201-13
TCMH2119 Tetrapanax papyriferus 通草 TCMH2119
TCMH1906 Cimicifuga foetida 升麻 TCMH1906
TCMH2630 Citrus aurantium 枳实 TCMH2630 ITSAA1279-14
TCMH501 Semen malvae verticillatae 冬葵子 TCMH501
Reference: Chinese Classical Prescriptions

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT17 POLB DNA polymerase beta Transferase P06746
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT186 MAOB Monoamine oxidase B Oxidoreductase P27338
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT206 CYP2A6 Cytochrome P450 2A6 Oxidoreductase P11509
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT221 ABCB11 Bile salt export pump Transporter O95342
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT289 TBXAS1 Thromboxane-A synthase Isomerase P24557
TCMT293 CHRM2 Muscarinic acetylcholine receptor M2 GPCR P08172
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT337 XPO1 Exportin-1 Unclassified O14980
TCMT359 FYN Tyrosine-protein kinase FYN Kinase P06241
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT39 PDE5A Phosphodiesterase 5A Hydrolase O76074
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT561 NT5E 5'-nucleotidase Hydrolase P21589
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT598 TOP1 DNA topoisomerase I Isomerase P11387
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT636 POLA1 DNA polymerase alpha subunit Transferase P09884
TCMT637 SIRT3 NAD-dependent deacetylase sirtuin 3 Hydrolase Q9NTG7
TCMT638 SIRT2 NAD-dependent deacetylase sirtuin 2 Hydrolase Q8IXJ6
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT801 TUBB3 Tubulin beta-3 chain Unclassified Q13509
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1182 Streptococcus sanguinis
TCMT1189 Pseudomonas fluorescens
TCMT1191 Bacillus megaterium
TCMT1207 Legionella pneumophila
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1221 Human herpesvirus 4
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1226 Klebsiella pneumoniae
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1236 Mycobacterium bovis
TCMT1243 Aspergillus flavus
TCMT1246 Escherichia coli
TCMT1247 Human herpesvirus 1
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1286 Bacillus cereus
TCMT1294 Human parainfluenza virus 3
TCMT1318 Human T-lymphotropic virus 1
TCMT1319 Corynebacterium xerosis
TCMT1321 Staphylococcus hominis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1444 Fusarium oxysporum
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0006629 lipid metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, ESR1, FABP3, FABP4, HSD11B1, HSD17B1, HSD17B2, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, TBXAS1 10.253
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, PTGS1, PTGS2, TBXAS1 9.53524
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, PTGS1, PTGS2, TBXAS1 8.82522
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, PTGS1, PTGS2, TBXAS1 8.56675
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, HSD11B1, HSD17B1, HSD17B2, MAOB, NQO2, PTGS1, PTGS2, TBXAS1, TYR, XDH 8.25955
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, ESR1, F10, FABP3, FABP4, FLT3, HSD17B1, HSD17B2, IGF1R, KDR, MAOB, MET, MMP1, MMP2, NQO2, PDE5A, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SRC, TBXAS1, TNKS, TNKS2, TOP1, TYR, XDH 8.25955
[BP] GO:0008152 metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, ESR1, F10, FABP3, FABP4, FLT3, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MAOB, MET, MMP1, MMP2, MMP9, NQO2, PDE5A, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SRC, TBXAS1, TNKS, TNKS2, TOP1, TYR, XDH 8.22449
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX15, ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, PDE5A, PIK3CA, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR, XDH 8.22449
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, AKR1B1, ALOX15, AURKB, AXL, CA12, CA2, CA7, CYP19A1, CYP1A1, CYP1B1, ESR1, F10, FABP3, FABP4, FLT3, HCAR2, HSD11B1, HSD17B1, HSD17B2, KDR, MAOB, MET, PIK3CA, PIK3CB, POLA1, POLB, PPARA, PTGS1, PTGS2, SRC, TNKS, TNKS2, XDH 8.18944
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, AXL, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, HSD17B2, IGF1R, MAOB, MMP2, MMP9, PIK3CA, POLB, PPARA, PTGS2, RORC, SRC, TYR 7.39818
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, PTGS1, PTGS2, TBXAS1 7.39023
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, PTGS1, PTGS2, TBXAS1 7.09927
[BP] GO:0042221 response to chemical ABCB1, AKR1B1, ALOX15, ALPL, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MAOB, MMP2, MMP9, PIK3CA, POLB, PPARA, PTGS2, RORC, SRC, TOP1, TYR 7.07681
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 7.00517
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2, TBXAS1 7.00517
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MAOB, MMP2, PIK3CA, POLB, PPARA, PTGS2, RORC, SRC, TYR 6.97191
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, PPARA, PTGS1, PTGS2, TBXAS1 6.87655
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2A6, TYR 6.65079
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, ESR1, HSD11B1, HSD17B1, HSD17B2 6.59003
[BP] GO:0010647 positive regulation of cell communication AKR1B1, ALOX15, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F10, FLT3, HCAR2, KDR, MET, MMP9, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 6.43677
[BP] GO:0023056 positive regulation of signaling AKR1B1, ALOX15, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F10, FLT3, HCAR2, KDR, MET, MMP9, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 6.42772
[BP] GO:0033993 response to lipid ALPL, AXL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, ESR1, FABP3, FLT3, HSD17B2, MAOB, PTGS2, RORC, SRC, TYR 6.3635
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 6.03036
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, AXL, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MAOB, MMP9, PTGS2, SRC 5.93196
[BP] GO:0032502 developmental process ACHE, AKR1B1, ALOX15, ALPL, AURKB, AXL, CA2, CA9, CBR1, CDC25B, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, HSD11B1, HSD17B2, KDR, MAOB, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, POLB, PPARA, PTGS2, PTPRS, RORC, SRC, TNKS2, TYR 5.49828
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD17B1, HSD17B2 5.40006
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, AURKB, AXL, CDC25B, CSNK2A1, FLT3, IGF1R, KDR, MET, PDE5A, PIK3CA, PIK3CB, PIM1, POLB, PTGS2, PTPN1, PTPRS, SRC, TNKS, TOP1, XDH 5.09514
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2 5.04604
[BP] GO:0048513 animal organ development ACHE, AXL, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, FLT3, HSD11B1, HSD17B2, KDR, PIK3CA, POLB, PPARA, PTPRS, SRC, TYR 5.00682
[BP] GO:0019371 None CBR1, PTGS1, PTGS2, TBXAS1 4.83975
[BP] GO:0032787 None ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, PPARA, PTGS1, PTGS2, TBXAS1 4.82387
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, AURKB, AXL, CDC25B, CSNK2A1, FLT3, IGF1R, KDR, MET, PDE5A, PIK3CA, PIK3CB, PIM1, POLB, PTGS2, PTPN1, PTPRS, SRC, TNKS, TOP1, XDH 4.79792
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.64049
[BP] GO:0014070 response to organic cyclic compound ALPL, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, MAOB, PTGS2, RORC, SRC, TYR 4.63774
[BP] GO:0048522 positive regulation of cellular process ACHE, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, F10, FABP3, FLT3, HCAR2, IGF1R, KDR, MAOB, MET, MMP1, MMP2, MMP9, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 4.44381
[BP] GO:0010941 regulation of cell death AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, HCAR2, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, SRC, XDH 4.39954
[BP] GO:0044238 primary metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AURKB, AXL, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, ESR1, F10, FABP3, FABP4, FLT3, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PDE5A, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SRC, TBXAS1, TNKS, TNKS2, TOP1, TYR, XDH 4.31632
[BP] GO:0009725 response to hormone AKR1B1, ALPL, CA2, CA9, CSNK2A1, CYP1A2, ESR1, FABP3, FLT3, MAOB, PPARA, PTGS2, SRC 4.28193
[BP] GO:0048856 anatomical structure development ACHE, AKR1B1, ALOX15, ALPL, AXL, CA2, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, FLT3, HSD11B1, HSD17B2, KDR, MAOB, MMP9, PIK3CA, PIM1, POLB, PPARA, PTGS2, PTPRS, RORC, SRC, TYR 4.27122
[BP] GO:0071704 organic substance metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AURKB, AXL, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, ESR1, F10, FABP3, FABP4, FLT3, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MAOB, MET, MMP1, MMP2, MMP9, PDE5A, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SRC, TBXAS1, TNKS, TNKS2, TOP1, TYR, XDH 4.26833
[BP] GO:0009967 positive regulation of signal transduction AKR1B1, ALOX15, AXL, CSNK2A1, CYP1B1, F10, FLT3, KDR, MET, MMP9, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 4.26833
[BP] GO:0043067 regulation of programmed cell death AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, HCAR2, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, XDH 4.25348
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, F10, FABP3, FABP4, FLT3, HCAR2, IGF1R, KDR, MAOB, MET, MMP1, MMP2, MMP9, PDE5A, PIK3CA, PIK3CB, PIM1, PPARA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 4.25348
[BP] GO:0050896 response to stimulus ABCB1, ACHE, AKR1B1, ALOX15, ALPL, AURKB, AXL, CA2, CA9, CHRM2, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, F10, FABP3, FABP4, FLT3, HSD17B2, IGF1R, KDR, MAOB, MMP2, MMP9, PIK3CA, PIK3CB, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, RORC, SRC, TOP1, TYR 4.21871
[BP] GO:1902533 positive regulation of intracellular signal transduction AKR1B1, ALOX15, AXL, CYP1B1, F10, FLT3, KDR, MET, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.95285
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, CA2, CA9, CSNK2A1, CYP1A2, ESR1, FABP3, FLT3, IGF1R, MAOB, MMP2, PPARA, PTGS2, SRC 3.91995
[BP] GO:0010646 regulation of cell communication ACHE, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, F10, FLT3, HCAR2, IGF1R, KDR, MET, MMP9, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, PTPRS, SRC, TNKS, TNKS2, XDH 3.87623
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR 3.85632
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC 3.82535
[BP] GO:0042493 response to drug ABCB1, AKR1B1, AXL, CA9, CYP1A1, CYP1B1, FABP3, KDR, MAOB, POLB, PTGS2, SRC, TOP1 3.82354
[BP] GO:0023051 regulation of signaling ACHE, AKR1B1, ALOX15, AURKB, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, F10, FLT3, HCAR2, IGF1R, KDR, MET, MMP9, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, PTPRS, SRC, TNKS, TNKS2, XDH 3.79556
[BP] GO:1902531 regulation of intracellular signal transduction AKR1B1, ALOX15, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, F10, FLT3, IGF1R, KDR, MET, MMP9, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 3.79556
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1, CYP2A6 3.78286
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, AXL, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, PIK3CA, PTGS2, RORC, SRC 3.76625
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, HCAR2, PIK3CB, PTGS2, TNKS, TNKS2 3.75232
[BP] GO:0032501 multicellular organismal process AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AXL, CYP19A1, CYP1A2, CYP1B1, ESR1, F10, FABP4, HSD17B2, IGF1R, MET, MMP1, MMP2, MMP9, PDE5A, PIK3CA, PIM1, PPARA, PTGS2, RORC, SRC, TNKS2, TOP1, TYR 3.71864
[BP] GO:0042981 regulation of apoptotic process AKR1B1, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, FLT3, HCAR2, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PIM1, PTGS2, PTPN1, SRC, XDH 3.69863
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, AURKB, AXL, CA2, CA9, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, PIK3CA, POLA1, POLB, PTGS2, PTPN1, RORC, SRC 3.65839
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 3.65839
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AURKB, CYP1A1, ESR1, FLT3, MET, PIK3CB, PIM1, POLA1, SRC, TYR 3.59244
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.59244
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1, MAOB 3.59244
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, AXL, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, PIK3CA, PTGS2, RORC, SRC 3.58621
[BP] GO:0043436 oxoacid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR 3.4433
[BP] GO:0060548 negative regulation of cell death AKR1B1, AURKB, AXL, CSNK2A1, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPN1, SRC 3.43604
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD17B1, HSD17B2 3.43604
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, NQO2, PTGS1, RORC 3.38658
[BP] GO:0050665 hydrogen peroxide biosynthetic process CYP1A1, CYP1A2, MAOB 3.38658
[BP] GO:0006082 organic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, PIM1, PPARA, PTGS1, PTGS2, TBXAS1, TYR 3.38658
[BP] GO:0048584 positive regulation of response to stimulus AKR1B1, ALOX15, AXL, CSNK2A1, CYP1B1, F10, FABP4, FLT3, KDR, MET, MMP2, MMP9, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 3.3085
[BP] GO:0032844 regulation of homeostatic process AURKB, CA2, CA7, HCAR2, KDR, PIK3CB, PTGS2, SRC, TNKS, TNKS2 3.24352
[BP] GO:0009056 catabolic process ACHE, AKR1B10, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, MAOB, MMP1, MMP2, MMP9, PDE5A, PIK3CB, SRC, XDH 3.21034
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.17303
[BP] GO:0043069 negative regulation of programmed cell death AKR1B1, AURKB, AXL, CSNK2A1, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SRC 3.16929
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 3.13558
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7 3.10868
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.10868
[BP] GO:0010817 regulation of hormone levels ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HCAR2, HSD11B1, HSD17B1, HSD17B2 3.01605
[BP] GO:0051896 regulation of protein kinase B signaling AXL, F10, MET, PIK3CA, PIK3CB, SRC, XDH 2.99763
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, CYP1A1, CYP1B1, KDR, MAOB, POLB, SRC 2.99763
[BP] GO:0046456 icosanoid biosynthetic process ALOX15, ALOX5, PTGS1, PTGS2 2.94653
[BP] GO:0006468 protein phosphorylation AURKB, AXL, CDC25B, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIM1, SRC, TNKS, TOP1 2.87836
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.83658
[BP] GO:0010038 response to metal ion ALOX15, CA2, CYP1A1, CYP1A2, FABP4, MAOB, MMP9, PTGS2 2.83658
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 2.80987
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PTPN1, SRC 2.80023
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.80023
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, F10, MET, PIK3CA, PIK3CB, SRC 2.78491
[BP] GO:0042127 regulation of cell proliferation AKR1B1, CDC25B, CSNK2A1, CYP1B1, ESR1, FABP3, FLT3, IGF1R, KDR, MMP2, MMP9, PDE5A, PIM1, PTGS1, PTGS2, SRC, XDH 2.7427
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.71061
[BP] GO:0022900 electron transport chain AKR1B1, CYP19A1, CYP1A2, MAOB, NQO2, XDH 2.64441
[BP] GO:0016310 phosphorylation AURKB, AXL, CDC25B, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC, TNKS, TOP1 2.6366
[BP] GO:0043066 negative regulation of apoptotic process AKR1B1, AURKB, AXL, CSNK2A1, IGF1R, KDR, MMP9, PIK3CA, PIM1, PTGS2, PTPN1, SRC 2.59606
[BP] GO:0044092 negative regulation of molecular function AURKB, CSNK2A1, CYP1B1, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PTGS2, PTPN1, SRC, TNKS 2.58778
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, CYP1A1, CYP1B1, ESR1, FLT3, PTGS2, RORC, SRC 2.58435
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.55571
[BP] GO:0019372 lipoxygenase pathway ALOX15, ALOX5, PTGS2 2.55571
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.52326
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AURKB, AXL, CDC25B, CSNK2A1, CYP1A1, CYP1A2, ESR1, F10, FLT3, IGF1R, KDR, MAOB, MET, MMP1, MMP2, MMP9, PDE5A, PIK3CA, PIM1, POLB, PPARA, PTGS2, PTPN1, PTPRS, SRC, TNKS, TNKS2, TOP1, TYR, XDH 2.51923
[BP] GO:0042592 homeostatic process AKR1B1, AXL, CA12, CA2, CA7, ESR1, FABP3, FABP4, FLT3, MET, PIK3CA, PIK3CB, POLA1, POLB, SRC 2.50248
[BP] GO:0019216 regulation of lipid metabolic process CYP1A1, FABP3, FLT3, HCAR2, PPARA, PTGS2, RORC, SRC 2.49872
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.4883
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AXL, CYP1B1, ESR1, IGF1R, MMP2, MMP9, PIK3CA, PTGS2, RORC, SRC 2.4187
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.4187
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.4187
[BP] GO:0048583 regulation of response to stimulus ABCB1, AKR1B1, ALOX15, AURKB, AXL, CSNK2A1, CYP19A1, CYP1B1, ESR1, F10, FABP4, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PDE5A, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, PTPRS, SRC, TNKS, TNKS2, XDH 2.41781
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.36417
[BP] GO:0032496 response to lipopolysaccharide ALPL, AXL, CYP1A1, CYP1A2, MAOB, PTGS2, SRC 2.36417
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.35017
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.33538
[BP] GO:0048511 rhythmic process AXL, CSNK2A1, ESR1, PPARA, RORC, SRC, TOP1 2.30681
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TNKS, TNKS2 2.25706
[BP] GO:0010562 positive regulation of phosphorus metabolic process ALOX15, CDC25B, FABP3, FLT3, KDR, MMP9, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.25015
[BP] GO:0045937 positive regulation of phosphate metabolic process ALOX15, CDC25B, FABP3, FLT3, KDR, MMP9, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.25015
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.24544
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.24225
[BP] GO:0001934 positive regulation of protein phosphorylation ALOX15, CDC25B, FLT3, KDR, MMP9, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.24225
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ALOX15, AXL, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F10, HCAR2, IGF1R, KDR, MAOB, MET, MMP9, PIK3CB, PPARA, PTGS2, PTPN1, SRC 2.23235
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALOX15, CSNK2A1, FABP3, FABP4, MET, PIK3CA, PIK3CB 2.22678
[BP] GO:0002237 response to molecule of bacterial origin ALPL, AXL, CYP1A1, CYP1A2, MAOB, PTGS2, SRC 2.22072
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, MAOB 2.22061
[BP] GO:0009987 cellular process ABCB1, ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, ESR1, F10, FABP3, FABP4, FLT3, HCAR2, HSD17B1, HSD17B2, IGF1R, KDR, MAOB, MET, MMP1, MMP2, MMP9, NQO2, PDE5A, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SRC, TBXAS1, TNKS, TNKS2, TOP1, TUBB3, TYR, XDH 2.20956
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, PTGS2, SRC 2.20484
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PTGS2, SRC 2.17403
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX15, CYP19A1, CYP1A1, CYP1B1, MAOB, TYR 2.17078
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD17B1, HSD17B2 2.16277
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.16111
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.16085
[BP] GO:0033031 positive regulation of neutrophil apoptotic process HCAR2, PIK3CB 2.11531
[BP] GO:0070213 None TNKS, TNKS2 2.11531
[BP] GO:0032847 regulation of cellular pH reduction CA2, CA7 2.11531
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.11531
[BP] GO:0042327 positive regulation of phosphorylation ALOX15, CDC25B, FLT3, KDR, MMP9, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, SRC, XDH 2.10095
[BP] GO:0042325 regulation of phosphorylation ALOX15, CDC25B, FABP4, FLT3, IGF1R, KDR, MMP9, PDE5A, PIK3CA, PIK3CB, PPARA, PTGS2, PTPN1, SRC, XDH 2.10018
[BP] GO:0009966 regulation of signal transduction AKR1B1, ALOX15, AURKB, AXL, CSNK2A1, CYP1B1, ESR1, F10, FLT3, IGF1R, KDR, MET, MMP9, PDE5A, PIK3CA, PIK3CB, PTGS2, PTPN1, PTPRS, SRC, TNKS, TNKS2, XDH 2.08966
[BP] GO:0048545 response to steroid hormone ALPL, CA2, FLT3, MAOB, PTGS2, SRC 2.05137
[BP] GO:0001101 response to acid chemical AKR1B1, FABP3, HSD17B2, KDR, MMP2, PTGS2, SRC 2.0343
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.02462
[BP] GO:0044248 cellular catabolic process ACHE, AKR1B10, AURKB, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, FABP3, FABP4, MAOB, PDE5A, PIK3CB, SRC, XDH 2.01111
[CC] GO:0044444 cytoplasmic part ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, AURKB, CA1, CA2, CA4, CA7, CBR1, CDC25B, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, ESR1, F10, FABP3, FABP4, FLT3, HSD11B1, HSD17B1, HSD17B2, KDR, MAOB, MMP2, MMP9, NQO2, PDE5A, PIK3CA, PIK3CB, PIM1, POLA1, PTGS1, PTGS2, PTPN1, PTPRS, SRC, TBXAS1, TNKS, TNKS2, TOP1, TYR, XDH 2.99763
[CC] GO:0016020 membrane ABCB1, ACHE, ALOX15, ALOX5, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, ESR1, F10, FLT3, HCAR2, HSD11B1, HSD17B2, IGF1R, KDR, MAOB, MET, MMP2, PIK3CA, PIK3CB, PIM1, PTGS1, PTGS2, PTPN1, PTPRS, SRC, TBXAS1, TNKS, TNKS2, TYR 2.22483
[CC] GO:0097443 sorting endosome KDR, PTPN1 1.80379
[CC] GO:0044432 endoplasmic reticulum part CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, F10, FLT3, HSD11B1, HSD17B2, PTGS1, PTGS2, PTPN1, TBXAS1 1.7015
[CC] GO:0044425 membrane part ABCB1, ACHE, ALOX15, ALPL, AXL, CA12, CA14, CA2, CA4, CA9, CHRM2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, ESR1, F10, FLT3, HCAR2, HSD11B1, HSD17B2, IGF1R, KDR, MAOB, MET, PIK3CA, PIK3CB, PTGS1, PTGS2, PTPN1, PTPRS, SRC, TBXAS1, TYR 1.44394
[MF] GO:0003824 catalytic activity ABCB1, ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, F10, FLT3, HSD11B1, HSD17B1, HSD17B2, IGF1R, KDR, MAOB, MET, MMP1, MMP2, MMP9, NQO2, PDE5A, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PTGS1, PTGS2, PTPN1, PTPRS, SRC, TBXAS1, TNKS, TNKS2, TOP1, TUBB3, TYR, XDH 16.3393
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX15, ALOX5, ALPL, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, ESR1, F10, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MAOB, MET, MMP1, MMP2, MMP9, NQO2, PDE5A, PIK3CA, PIK3CB, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SRC, TBXAS1, TNKS, TNKS2, TOP1, TUBB3, TYR, XDH 14.6715
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, ESR1, MMP1, MMP2, MMP9, NQO2, PIM1, PPARA, PTPN1, RORC, TBXAS1, TNKS, TYR, XDH 12.4395
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 10.1679
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, ALOX5, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, HSD11B1, HSD17B1, HSD17B2, MAOB, NQO2, PTGS1, PTGS2, TBXAS1, TYR, XDH 9.68793
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9, POLB 6.98171
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, ESR1, F10, MMP1, MMP2, MMP9, NQO2, PDE5A, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, RORC, TBXAS1, TNKS, TNKS2, TYR, XDH 6.94143
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, PTGS1, PTGS2, SRC, TBXAS1 6.63031
[MF] GO:0048037 cofactor binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, HSD17B1, MAOB, NQO2, POLA1, PTGS1, PTGS2, SRC, TBXAS1, XDH 6.61547
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, ESR1, F10, MMP1, MMP2, MMP9, NQO2, PDE5A, PIM1, POLA1, POLB, PPARA, PTGS1, PTGS2, PTPN1, RORC, TBXAS1, TNKS, TNKS2, TYR, XDH 6.59367
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.49058
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, PTGS1, PTGS2, SRC, TBXAS1 6.42799
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, PTGS1, PTGS2, TBXAS1, TYR 6.03036
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, TBXAS1, XDH 5.93196
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6 5.03908
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2A6, TBXAS1, TYR 4.97402
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, ESR1, MMP1, MMP2, MMP9, NQO2, PPARA, PTPN1, RORC, TNKS 4.85217
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CHRM2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, FLT3, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, SRC, TOP1 4.72129
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9, POLB 4.30684
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, CBR1, HSD11B1, HSD17B1, HSD17B2, XDH 4.05062
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1 3.65459
[MF] GO:0009055 electron transfer activity AKR1B1, CYP19A1, CYP1A2, MAOB, NQO2, XDH 3.48897
[MF] GO:0043168 anion binding ABCB1, ALOX15, AURKB, AXL, CSNK2A1, F10, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MAOB, MET, NQO2, PDE5A, PIK3CA, PIK3CB, PIM1, PTPRS, SRC, TOP1, TUBB3, XDH 3.43604
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.40544
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HSD11B1, HSD17B1, HSD17B2 3.29065
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, POLA1, POLB, SRC, TOP1 3.1733
[MF] GO:0036094 small molecule binding ABCB1, AURKB, AXL, CSNK2A1, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MAOB, MET, NQO2, PDE5A, PIK3CA, PIK3CB, PIM1, POLA1, SRC, TOP1, TUBB3, XDH 3.15317
[MF] GO:0000166 nucleotide binding ABCB1, AURKB, AXL, CSNK2A1, FLT3, HSD17B1, IGF1R, KDR, MAOB, MET, NQO2, PDE5A, PIK3CA, PIK3CB, PIM1, POLA1, SRC, TOP1, TUBB3, XDH 2.99763
[MF] GO:1901265 nucleoside phosphate binding ABCB1, AURKB, AXL, CSNK2A1, FLT3, HSD17B1, IGF1R, KDR, MAOB, MET, NQO2, PDE5A, PIK3CA, PIK3CB, PIM1, POLA1, SRC, TOP1, TUBB3, XDH 2.99763
[MF] GO:0043560 insulin receptor substrate binding IGF1R, PIK3CA, PIK3CB 2.99763
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.97663
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC, TOP1 2.9204
[MF] GO:0004672 protein kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIM1, SRC, TOP1 2.90935
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.74604
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1 2.64883
[MF] GO:0016301 kinase activity AURKB, AXL, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, SRC, TOP1 2.58932
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.4187
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.35017
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX15, ALOX5, PTGS2 2.02462


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 9.6977
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 11.2438
Metabolic pathways_Homo sapiens_hsa01100 CBR1, MAOB, ALOX15, AKR1B1, PTGS2, TYR, CYP19A1, PTGS1, HSD11B1, POLA1, CYP2A6, AKR1B10, ALOX5, HSD17B1, TBXAS1, HSD17B2, CYP1A2, CYP1A1, ALPL, XDH 7.6996
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 7.6996
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, SRC, MMP2, KDR, PIK3CB, MMP9, MET, ESR1, IGF1R 6.5014
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, TBXAS1, PTGS2, PTGS1 6.0843
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP2A6, CYP1A2, CYP1A1, CYP1B1, PTGS2 6.7196
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP2A6, CYP1A2, CYP1A1, CYP1B1 5.7115
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1 5.0171
Pathways in cancer_Homo sapiens_hsa05200 PIK3CA, FLT3, MMP1, MMP2, PIK3CB, PTGS2, MMP9, MET, IGF1R 4.4259
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, PIK3CB, PTGS2, PTGS1 4.9363
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, SRC, KDR, PIK3CB, PTGS2 4.787
MicroRNAs in cancer_Homo sapiens_hsa05206 ABCB1, PIK3CA, PIM1, CYP1B1, PTGS2, MMP9, MET, CDC25B 4.4259
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.4259
Serotonergic synapse_Homo sapiens_hsa04726 MAOB, ALOX5, ALOX15, PTGS2, PTGS1 3.6625
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, SRC, KDR, PIK3CB, MET, IGF1R 3.5508
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, SRC, KDR, PIK3CB, MET, IGF1R 3.4685
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, TBXAS1, PIK3CB, PTGS1 3.5508
Tryptophan metabolism_Homo sapiens_hsa00380 MAOB, CYP1A2, CYP1A1, CYP1B1 4.1665
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, PIM1, PIK3CB 3.6225
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.1492
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, PIK3CB, MET 3.4276
Melanoma_Homo sapiens_hsa05218 PIK3CA, PIK3CB, MET, IGF1R 3.3648
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1 3.358
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIK3CA, MMP2, PIM1, PIK3CB 2.8359
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, CDC25B, IGF1R 2.871
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.3959
cAMP signaling pathway_Homo sapiens_hsa04024 CHRM2, HCAR2, PIK3CA, PIK3CB, PPARA 2.7364
Cholinergic synapse_Homo sapiens_hsa04725 CHRM2, ACHE, PIK3CA, PIK3CB 2.7357
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 3.2385
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.7364
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, PIK3CB, PPARA 2.7364
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CHRM2, PIK3CA, KDR, PIK3CB, MET, IGF1R 2.5549
Ras signaling pathway_Homo sapiens_hsa04014 PIK3CA, KDR, PIK3CB, MET, IGF1R 2.5396
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, SRC, PIK3CB, ESR1 2.6605
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PIK3CB, MMP9 2.6605
Hepatitis B_Homo sapiens_hsa05161 PIK3CA, SRC, PIK3CB, MMP9 2.3832
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, SRC, PIK3CB, PTGS2 2.2873
Glioma_Homo sapiens_hsa05214 PIK3CA, PIK3CB, IGF1R 2.3832
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, PIK3CB, IGF1R 2.3832
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.1
Viral carcinogenesis_Homo sapiens_hsa05203 POLB, PIK3CA, SRC, PIK3CB 1.9586
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, PIK3CB 1.9731
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, PIK3CB, IGF1R 2.0741
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 2.38
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 CHRM2, PIK3CA, SRC, PIK3CB 1.9205
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, SRC, PIK3CB 2.0932
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, PIK3CB, IGF1R 2.0157
Retinol metabolism_Homo sapiens_hsa00830 CYP2A6, CYP1A2, CYP1A1 2.3832
Small cell lung cancer_Homo sapiens_hsa05222 PIK3CA, PIK3CB, PTGS2 2.0984
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2A6, MAOB, CYP1A2 2.3342
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, PIK3CB, IGF1R 1.9454
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.697
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, PIK3CB 1.8184
FoxO signaling pathway_Homo sapiens_hsa04068 PIK3CA, PIK3CB, IGF1R 1.7036
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, PIK3CB, IGF1R 1.7734
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA 1.7036
Measles_Homo sapiens_hsa05162 CSNK2A1, PIK3CA, PIK3CB 1.697
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PIK3CA, PIK3CB 1.684
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, PIK3CB, PPARA 1.6112
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 PIK3CA, PIK3CB, IGF1R 1.6712
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, PIM1, PIK3CB 1.5682
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, PDE5A, PIK3CB 1.523
Purine metabolism_Homo sapiens_hsa00230 POLA1, PDE5A, XDH 1.4738
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, PIK3CB 1.3641
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, SRC, PIK3CB 1.4327
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 CHRM2 0.237
MAPK signaling pathway_Homo sapiens_hsa04010 CDC25B 0.2574
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3524
Tuberculosis_Homo sapiens_hsa05152 SRC 0.3584
Calcium signaling pathway_Homo sapiens_hsa04020 CHRM2 0.3584
Alcoholism_Homo sapiens_hsa05034 MAOB 0.3584
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 1.127
HTLV-I infection_Homo sapiens_hsa05166 POLB, PIK3CA, PIK3CB 1.1512
Phagosome_Homo sapiens_hsa04145 TUBB3 0.4016
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1 0.4267
Apoptosis_Homo sapiens_hsa04210 PIK3CA, PIK3CB 1.0015
Cell cycle_Homo sapiens_hsa04110 CDC25B 0.4653
Axon guidance_Homo sapiens_hsa04360 MET 0.4599
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4653
Dopaminergic synapse_Homo sapiens_hsa04728 MAOB 0.4573
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC 1.0029
Influenza A_Homo sapiens_hsa05164 PIK3CA, PIK3CB 0.8636
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PIK3CB 1.021
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, PIK3CB 0.9714
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 1.0339
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PIK3CA, PIK3CB 0.988
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PIK3CB 1.1981
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2 1.2574
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PIK3CB 1.2496
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 PIK3CA, PIK3CB 1.1841
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 1.178
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, PIK3CB 1.1028
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PIK3CB 1.2014
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 1.1841
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PIK3CB 1.2128
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, PIK3CB 1.1028
Melanogenesis_Homo sapiens_hsa04916 TYR 0.5309
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5309
Pyrimidine metabolism_Homo sapiens_hsa00240 POLA1 0.5197
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5414
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PTGS2 0.5309
Pancreatic secretion_Homo sapiens_hsa04972 CA2 0.5406
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, PTGS2 1.2496
Gap junction_Homo sapiens_hsa04540 SRC, TUBB3 1.2793
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5585
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5607
GABAergic synapse_Homo sapiens_hsa04727 SRC 0.5607
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5596
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PIK3CB 1.4525
Peroxisome_Homo sapiens_hsa04146 XDH 0.5764
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.4201
Chronic myeloid leukemia_Homo sapiens_hsa05220 PIK3CA, PIK3CB 1.4201
Complement and coagulation cascades_Homo sapiens_hsa04610 F10 0.5919
Pancreatic cancer_Homo sapiens_hsa05212 PIK3CA, PIK3CB 1.4664
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.6158
Gastric acid secretion_Homo sapiens_hsa04971 CA2 0.6139
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PIK3CB 1.523
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.4327
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.6287
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2 1.4327
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.4525
Colorectal cancer_Homo sapiens_hsa05210 PIK3CA, PIK3CB 1.5068
Amphetamine addiction_Homo sapiens_hsa05031 MAOB 0.6424
Non-small cell lung cancer_Homo sapiens_hsa05223 PIK3CA, PIK3CB 1.5682
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB 1.6121
Shigellosis_Homo sapiens_hsa05131 SRC 0.6509
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.5308
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.6509
Long-term depression_Homo sapiens_hsa04730 IGF1R 0.6757
Caffeine metabolism_Homo sapiens_hsa00232 CYP2A6, CYP1A2, XDH 5.313
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 TUBB3 0.7066
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.697
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, PIK3CB 1.6712
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 PIK3CA, PIK3CB 1.7815
Malaria_Homo sapiens_hsa05144 MET 0.7459
Arginine and proline metabolism_Homo sapiens_hsa00330 MAOB 0.7414
Cocaine addiction_Homo sapiens_hsa05030 MAOB 0.7459
Drug metabolism - other enzymes_Homo sapiens_hsa00983 CYP2A6, XDH 1.6897
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 ESR1 0.7555
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.9523
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.7786
Tyrosine metabolism_Homo sapiens_hsa00350 MAOB, TYR 1.8514
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 1.965
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.8351
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.9205
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.1023
Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 MAOB 0.8136
DNA replication_Homo sapiens_hsa03030 POLA1 0.8533
Base excision repair_Homo sapiens_hsa03410 POLB 0.8814
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.9172
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.957
Histidine metabolism_Homo sapiens_hsa00340 MAOB 0.9948
Phenylalanine metabolism_Homo sapiens_hsa00360 MAOB 1.1113
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.178


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)