TCM Prescription: Qing Xin Lian Zi Yin



Prescription Description
Prescription IDTCMF5814
Pinyin NameQing Xin Lian Zi Yin
Chinese Name清心莲子饮
English NameQing Xin Lian Zi Yin
Function Description遗精, 消渴
IndicationsInvoluntary ejaculation disorder, Wasting thirst disorder, Diabetes
Disease ICD-11 Category SB09 [Involuntary ejaculation disorder (TM1), 遗精 (TM1) ];
SD71 [Wasting thirst disorder (TM1), 消渴 (TM1) ];
5A14 [Diabetes mellitus, type unspecified, 糖尿病，未特指类型 ];
Human Tissues Associated with IndicationPancreas, Blood
ReferenceCFDA
Reference Book/linkhttp://samr.cfda.gov.cn/WS01/CL0001/
Prescription Components
Component ID Latin Name Chinese Name Component Quantity Barcode
TCMH1942 Semen nelumbinis 石莲子 TCMH1942
TCMH986 Scutellaria baicalensis 黄芩 TCMH986 ITSAP4211-14
TCMH449 Cortex lycii radicis 地骨皮 TCMH449
TCMH241 Plantago asiatica 车前子 TCMH241 ITSAB3641-14
TCMH606 Wolfiporia cocos 茯苓 TCMH606 GBPOL314-13
TCMH228 Bupleurum chinense 柴胡 TCMH228 ITSAM2218-14
TCMH981 Astragalus membranaceus 黄芪 TCMH981 ITSAK2981-14
TCMH1721 Panax ginseng 人参 TCMH1721 GBVE1679-11
TCMH1423 Ophiopogon japonicus 麦冬 TCMH1423 ITSAJ4140-14
TCMH628 Glycyrrhiza uralensis 甘草 TCMH628 ITSAM892-14
Reference: CFDA

Targeted Human Proteins by the Ingredients of Prescription

Target ID Gene Symbol Target Name Target Class Uniprot ID
TCMT101 PTPN1 Protein-tyrosine phosphatase 1B Hydrolase P18031
TCMT102 ACP1 Low molecular weight phosphotyrosine protein phosphatase Hydrolase P24666
TCMT103 PTPRF Receptor-type tyrosine-protein phosphatase F (LAR) Hydrolase P10586
TCMT112 ADORA3 Adenosine A3 receptor GPCR P0DMS8
TCMT127 PARP1 Poly [ADP-ribose] polymerase-1 Transferase P09874
TCMT128 TNKS2 Tankyrase-2 Transferase Q9H2K2
TCMT129 TNKS Tankyrase-1 Transferase O95271
TCMT130 ALOX5 Arachidonate 5-lipoxygenase Oxidoreductase P09917
TCMT131 ACHE Acetylcholinesterase Hydrolase P22303
TCMT133 CA1 Carbonic anhydrase I Lyase P00915
TCMT134 CA2 Carbonic anhydrase II Lyase P00918
TCMT135 CA14 Carbonic anhydrase XIV Lyase Q9ULX7
TCMT136 CA12 Carbonic anhydrase XII Lyase O43570
TCMT137 CA9 Carbonic anhydrase IX Lyase Q16790
TCMT138 CA7 Carbonic anhydrase VII Lyase P43166
TCMT142 CA4 Carbonic anhydrase IV Lyase P22748
TCMT150 RORC Nuclear receptor ROR-gamma Nuclear receptor P51449
TCMT151 PRKCA Protein kinase C alpha Kinase P17252
TCMT156 CYP19A1 Cytochrome P450 19A1 Oxidoreductase P11511
TCMT159 TYR Tyrosinase Oxidoreductase P14679
TCMT161 HCAR2 Hydroxycarboxylic acid receptor 2 GPCR Q8TDS4
TCMT162 UGT1A1 UDP-glucuronosyltransferase 1-1 Transferase P22309
TCMT164 PTGS1 Cyclooxygenase-1 Oxidoreductase P23219
TCMT174 HSD11B1 11-beta-hydroxysteroid dehydrogenase 1 Oxidoreductase P28845
TCMT190 PTPN2 T-cell protein-tyrosine phosphatase Hydrolase P17706
TCMT197 PDE4D Phosphodiesterase 4D Hydrolase Q08499
TCMT209 HSD11B2 11-beta-hydroxysteroid dehydrogenase 2 Oxidoreductase P80365
TCMT212 SRC Tyrosine-protein kinase SRC Kinase P12931
TCMT215 CYP1A1 Cytochrome P450 1A1 Oxidoreductase P04798
TCMT217 CYP2C8 Cytochrome P450 2C8 Oxidoreductase P10632
TCMT219 CYP1A2 Cytochrome P450 1A2 Oxidoreductase P05177
TCMT223 AKR1B1 Aldose reductase Oxidoreductase P15121
TCMT23 ALPL Alkaline phosphatase, tissue-nonspecific isozyme Hydrolase P05186
TCMT231 GBA2 Beta-glucosidase Hydrolase Q9HCG7
TCMT232 ABCB1 P-glycoprotein 1 Transporter P08183
TCMT236 ESR2 Estrogen receptor beta Nuclear receptor Q92731
TCMT239 PIM1 Serine/threonine-protein kinase PIM1 Kinase P11309
TCMT240 AMY1A Salivary alpha-amylase Unclassified P04745
TCMT249 CDK6 Cyclin-dependent kinase 6 Kinase Q00534
TCMT254 CBR1 Carbonyl reductase [NADPH] 1 Oxidoreductase P16152
TCMT257 CYP1B1 Cytochrome P450 1B1 Oxidoreductase Q16678
TCMT260 FLT3 Tyrosine-protein kinase receptor FLT3 Kinase P36888
TCMT261 DAPK1 Death-associated protein kinase 1 Kinase P53355
TCMT280 AKR1B10 Aldo-keto reductase family 1 member B10 Oxidoreductase O60218
TCMT283 PTPRS Receptor-type tyrosine-protein phosphatase S Hydrolase Q13332
TCMT295 MMP1 Matrix metalloproteinase-1 Hydrolase P03956
TCMT296 ADORA1 Adenosine A1 receptor GPCR P30542
TCMT297 FABP4 Fatty acid binding protein adipocyte Unclassified P15090
TCMT298 FABP3 Fatty acid binding protein muscle Hydrolase P05413
TCMT3 ALOX15 Arachidonate 15-lipoxygenase Oxidoreductase P16050
TCMT30 PTGS2 Cyclooxygenase-2 Oxidoreductase P35354
TCMT306 MMP2 Matrix metalloproteinase-2 Hydrolase P08253
TCMT321 MMP9 Matrix metalloproteinase 9 Hydrolase P14780
TCMT322 MMP13 Matrix metalloproteinase 13 Hydrolase P45452
TCMT329 NQO2 Quinone reductase 2 Oxidoreductase P16083
TCMT34 CYP2D6 Cytochrome P450 2D6 Oxidoreductase P10635
TCMT344 AOX1 Aldehyde oxidase Oxidoreductase Q06278
TCMT369 IGF1R Insulin-like growth factor I receptor Kinase P08069
TCMT370 KDR Vascular endothelial growth factor receptor 2 Kinase P35968
TCMT374 AURKB Serine/threonine-protein kinase Aurora-B Kinase Q96GD4
TCMT384 GRK6 G protein-coupled receptor kinase 6 Kinase P43250
TCMT388 AXL Tyrosine-protein kinase receptor UFO Kinase P30530
TCMT401 MET Hepatocyte growth factor receptor Kinase P08581
TCMT422 CAMK2B CaM kinase II beta Kinase Q13554
TCMT445 NEK2 Serine/threonine-protein kinase NEK2 Kinase P51955
TCMT46 F3 Coagulation factor III Unclassified P13726
TCMT462 NEK6 Serine/threonine-protein kinase NEK6 Kinase Q9HC98
TCMT47 BCL2 Apoptosis regulator Bcl-2 Ion channel P10415
TCMT479 AKT1 Serine/threonine-protein kinase AKT Kinase P31749
TCMT484 PLK1 Serine/threonine-protein kinase PLK1 Kinase P53350
TCMT506 PTK2B Protein tyrosine kinase 2 beta Kinase Q14289
TCMT508 SYK Tyrosine-protein kinase SYK Kinase P43405
TCMT560 F10 Coagulation factor X Unclassified P00742
TCMT563 CDC25B Dual specificity phosphatase Cdc25B Hydrolase P30305
TCMT591 ESRRA Estrogen-related receptor alpha Nuclear receptor P11474
TCMT592 XDH Xanthine dehydrogenase Oxidoreductase P47989
TCMT597 SLC28A3 Solute carrier family 28 member 3 Transporter Q9HAS3
TCMT598 TOP1 DNA topoisomerase I Isomerase P11387
TCMT599 UBE2N Ubiquitin-conjugating enzyme E2 N Transferase P61088
TCMT614 EGLN1 Egl nine homolog 1 Oxidoreductase Q9GZT9
TCMT63 PPARA Peroxisome proliferator-activated receptor alpha Nuclear receptor Q07869
TCMT65 HSD17B1 Estradiol 17-beta-dehydrogenase 1 Oxidoreductase P14061
TCMT66 HSD17B2 Estradiol 17-beta-dehydrogenase 2 Oxidoreductase P37059
TCMT698 PDE4B Phosphodiesterase 4B Hydrolase Q07343
TCMT709 SLC28A2 Sodium/nucleoside cotransporter 2 Transporter O43868
TCMT710 SLC28A1 Sodium/nucleoside cotransporter 1 Transporter O00337
TCMT729 PIK3CA PI3-kinase p110-alpha subunit Transferase P42336
TCMT730 PIK3CB PI3-kinase p110-beta subunit Transferase P42338
TCMT752 CSNK2A1 Casein kinase II alpha Kinase P68400
TCMT771 ATR Serine-protein kinase ATR Kinase Q13535
TCMT784 AVPR2 Vasopressin V2 receptor GPCR P30518
TCMT785 CXCR1 Interleukin-8 receptor A GPCR P25024
TCMT786 CCR4 C-C chemokine receptor type 4 GPCR P51679
TCMT791 PKN1 Protein kinase N1 Kinase Q16512
TCMT793 PYGL Liver glycogen phosphorylase Transferase P06737
TCMT8 KDM4E Lysine-specific demethylase 4D-like Oxidoreductase B2RXH2
TCMT801 TUBB3 Tubulin beta-3 chain Unclassified Q13509
TCMT808 FABP5 Fatty acid binding protein epidermal Unclassified Q01469
TCMT809 FABP2 Fatty acid binding protein intestinal Unclassified P12104
TCMT810 TLR2 Toll-like receptor 2 Unclassified O60603
TCMT82 ESR1 Estrogen receptor alpha Nuclear receptor P03372
TCMT822 FUT7 Alpha-(1,3)-fucosyltransferase 7 Transferase Q11130
TCMT848 ERN1 Serine/threonine-protein kinase/endoribonuclease IRE1 Kinase O75460
TCMT87 CYP2C9 Cytochrome P450 2C9 Oxidoreductase P11712
TCMT910 ESRRB Estrogen-related receptor beta Nuclear receptor O95718


Targeted Pathogenic Microbes by the Ingredients of Prescription

Target ID Target Name
TCMT1170 Enterobacter cloacae
TCMT1172 Staphylococcus aureus subsp. aureus RN4220
TCMT1175 Human immunodeficiency virus
TCMT1176 Streptococcus pneumoniae
TCMT1178 Actinomyces viscosus
TCMT1179 Escherichia coli ATCC 8739
TCMT1181 Mycobacterium tuberculosis H37Ra
TCMT1182 Streptococcus sanguinis
TCMT1186 Plasmodium yoelii yoelii
TCMT1191 Bacillus megaterium
TCMT1208 Escherichia coli K12
TCMT1209 Staphylococcus haemolyticus
TCMT1210 Streptococcus sobrinus
TCMT1211 Fusobacterium nucleatum
TCMT1212 Verticillium dahliae
TCMT1213 Neisseria gonorrhoeae
TCMT1214 Enterococcus faecium
TCMT1215 Pseudomonas aeruginosa PAO1
TCMT1217 Bacillus anthracis
TCMT1218 Staphylococcus aureus
TCMT1222 Plasmodium falciparum D6
TCMT1223 Staphylococcus epidermidis
TCMT1224 Proteus mirabilis
TCMT1226 Klebsiella pneumoniae
TCMT1227 Streptococcus
TCMT1229 Enterococcus faecalis
TCMT1232 Pseudomonas aeruginosa
TCMT1234 Bacillus coagulans
TCMT1235 Clostridium sporogenes
TCMT1236 Mycobacterium bovis
TCMT1237 Mycobacterium kansasii
TCMT1238 Mycobacterium xenopi
TCMT1239 Mycobacterium marinum
TCMT1243 Aspergillus flavus
TCMT1246 Escherichia coli
TCMT1248 Hepatitis C virus
TCMT1249 Dengue virus 2
TCMT1251 Candida albicans
TCMT1253 Penicillium chrysogenum
TCMT1255 Human immunodeficiency virus 1
TCMT1260 Streptococcus agalactiae
TCMT1284 Penicillium expansum
TCMT1286 Bacillus cereus
TCMT1289 Shigella dysenteriae
TCMT1292 Japanese encephalitis virus
TCMT1294 Human parainfluenza virus 3
TCMT1319 Corynebacterium xerosis
TCMT1321 Staphylococcus hominis
TCMT1322 Streptococcus mitis
TCMT1323 Corynebacterium pseudodiphtheriticum
TCMT1324 Corynebacterium diphtheriae
TCMT1336 Yellow fever virus
TCMT1337 Dengue virus type 4
TCMT1338 Rift Valley fever virus
TCMT1343 Staphylococcus simulans
TCMT1344 Staphylococcus sciuri
TCMT1346 Helicobacter pylori
TCMT1349 Helicobacter pylori SS1
TCMT1361 Neisseria meningitidis
TCMT1370 Prevotella melaninogenica
TCMT1382 Plasmodium falciparum (isolate K1 / Thailand)
TCMT1393 Vibrio sp.
TCMT1410 Listeria monocytogenes
TCMT1412 Salmonella typhimurium
TCMT1438 Plasmodium falciparum
TCMT1439 Mycobacterium smegmatis
TCMT1442 Leishmania donovani
TCMT1443 Leishmania amazonensis
TCMT1447 Respiratory syncytial virus
TCMT1448 Enterobacter aerogenes
TCMT1449 Influenza A virus
TCMT1450 Plasmodium falciparum 3D7
TCMT1454 Bacillus subtilis
TCMT1455 Mycobacterium tuberculosis H37Rv
TCMT1457 Leishmania major
TCMT1458 Filobasidiella neoformans
TCMT1462 Streptococcus mutans
TCMT1463 Mycobacterium tuberculosis
TCMT1464 Hepatitis B virus
TCMT1465 Entamoeba histolytica

Gene Ontology Associated to Targeted Human Proteins

GO Term GO Name Enriched Genes Log10 Adjusted P-value
[BP] GO:0006629 lipid metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, CBR1, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, FABP3, FABP4, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 11.9406
[BP] GO:0008152 metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SRC, TNKS, TNKS2, TOP1, TYR, XDH 9.75099
[BP] GO:0065008 regulation of biological quality ABCB1, ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA12, CA2, CA7, CDK6, CYP19A1, CYP1A1, CYP1B1, ESR1, F10, F3, FABP3, FABP4, FLT3, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KDR, MET, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS1, PTGS2, SRC, TNKS, TNKS2, XDH 8.40843
[BP] GO:0008202 steroid metabolic process AKR1B1, AKR1B10, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 8.05398
[BP] GO:0033993 response to lipid ALPL, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, HSD17B2, PTGS2, RORC, SRC, TYR 7.981
[BP] GO:1901700 response to oxygen-containing compound AKR1B1, ALPL, AXL, BCL2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, HSD11B2, HSD17B2, IGF1R, MMP2, MMP9, PIK3CA, PPARA, PTGS2, RORC, SRC, TYR 7.94838
[BP] GO:0010033 response to organic substance AKR1B1, ALOX15, ALPL, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, IGF1R, KDR, MMP2, PIK3CA, PPARA, PRKCA, PTGS2, RORC, SRC, TYR 7.84559
[BP] GO:0042221 response to chemical ABCB1, AKR1B1, ALOX15, ALPL, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, IGF1R, KDR, MMP2, MMP9, PIK3CA, PPARA, PRKCA, PTGS2, RORC, SRC, TOP1, TYR 7.84559
[BP] GO:0044281 small molecule metabolic process AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, FUT7, GBA2, PIK3CA, PIM1, PPARA, PTGS1, PTGS2, TYR, XDH 7.84559
[BP] GO:0019748 secondary metabolic process AKR1B1, AKR1B10, BCL2, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TYR 7.84559
[BP] GO:0044237 cellular metabolic process ACHE, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, F10, FABP3, FABP4, FLT3, FUT7, GBA2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SRC, TNKS, TNKS2, TOP1, TYR, XDH 7.75171
[BP] GO:0019369 arachidonic acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2 7.69036
[BP] GO:0055114 oxidation-reduction process AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, HSD11B1, HSD11B2, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH 7.53671
[BP] GO:0010647 positive regulation of cell communication ADORA1, AKR1B1, ALOX15, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F10, F3, FLT3, HCAR2, KDR, MET, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 7.52821
[BP] GO:0023056 positive regulation of signaling ADORA1, AKR1B1, ALOX15, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, F10, F3, FLT3, HCAR2, KDR, MET, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 7.50939
[BP] GO:0033559 unsaturated fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2 7.21583
[BP] GO:0044255 cellular lipid metabolic process ACHE, AKR1B10, ALOX15, ALOX5, CBR1, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, FABP4, FUT7, GBA2, MET, PIK3CA, PIK3CB, PPARA, PTGS1, PTGS2 7.06904
[BP] GO:0006690 icosanoid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2 6.97829
[BP] GO:0015701 bicarbonate transport CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.7873
[BP] GO:0032502 developmental process ACHE, ADORA1, AKR1B1, ALOX15, ALPL, AURKB, AXL, BCL2, CA2, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD17B2, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS2, PTPRS, RORC, SRC, TNKS2, TYR 6.7301
[BP] GO:0044238 primary metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SRC, TNKS, TNKS2, TOP1, TYR, XDH 6.41907
[BP] GO:0048522 positive regulation of cellular process ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FLT3, HCAR2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 6.16156
[BP] GO:0010941 regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HCAR2, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS2, PTPN1, SRC, XDH 6.15601
[BP] GO:0042445 hormone metabolic process ACHE, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 6.1277
[BP] GO:0043067 regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HCAR2, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS2, PTPN1, SRC, XDH 6.06987
[BP] GO:0001676 long-chain fatty acid metabolic process ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2 5.80772
[BP] GO:0006730 one-carbon metabolic process CA1, CA12, CA2, CA4, CA7, CA9 5.74438
[BP] GO:0048513 animal organ development ACHE, AXL, BCL2, CA2, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, ESR1, ESRRA, ESRRB, FLT3, HSD11B1, HSD17B2, KDR, PIK3CA, PPARA, PTPRS, SRC, TYR 5.7026
[BP] GO:0071704 organic substance metabolic process ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SRC, TNKS, TNKS2, TOP1, TYR, XDH 5.69535
[BP] GO:0048518 positive regulation of biological process ABCB1, ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, HCAR2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 5.67197
[BP] GO:0014070 response to organic cyclic compound ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, FLT3, HSD11B2, PTGS2, RORC, SRC, TYR 5.67197
[BP] GO:1901568 fatty acid derivative metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2 5.67197
[BP] GO:0042127 regulation of cell proliferation ADORA1, ADORA3, AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, CYP1B1, ESR1, ESRRA, F3, FABP3, FLT3, IGF1R, KDR, MMP2, MMP9, PIM1, PRKCA, PTGS1, PTGS2, SRC, XDH 5.58976
[BP] GO:0042981 regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F3, FLT3, HCAR2, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS2, PTPN1, SRC, XDH 5.53338
[BP] GO:1902533 positive regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, AXL, BCL2, CYP1B1, F10, F3, FLT3, KDR, MET, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, XDH 5.53338
[BP] GO:0009967 positive regulation of signal transduction ADORA1, AKR1B1, ALOX15, AXL, BCL2, CSNK2A1, CYP1B1, F10, F3, FLT3, KDR, MET, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 5.49617
[BP] GO:0006631 fatty acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, PPARA, PTGS1, PTGS2 5.46717
[BP] GO:0008610 lipid biosynthetic process ACHE, AKR1B1, ALOX15, CSNK2A1, CYP19A1, CYP1A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PIK3CA, PIK3CB, PTGS1, PTGS2 5.46717
[BP] GO:0010035 response to inorganic substance AKR1B1, ALOX15, AXL, BCL2, CA2, CYP1A1, CYP1A2, CYP1B1, FABP4, KDR, MMP9, PTGS2, SRC 5.45268
[BP] GO:0009725 response to hormone AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, PPARA, PTGS2, SRC 5.42895
[BP] GO:0032844 regulation of homeostatic process ADORA1, AURKB, BCL2, CA2, CA7, CDK6, HCAR2, KDR, PIK3CB, PTGS2, SRC, TNKS, TNKS2 5.33474
[BP] GO:0010817 regulation of hormone levels ACHE, ADORA1, AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HCAR2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, PRKCA 5.0411
[BP] GO:0060548 negative regulation of cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PPARA, PRKCA, PTGS2, PTPN1, SRC 5.01008
[BP] GO:0010646 regulation of cell communication ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F10, F3, FLT3, HCAR2, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, PTPRS, SRC, TNKS, TNKS2, XDH 5.01008
[BP] GO:0006796 phosphate-containing compound metabolic process ACHE, ALOX15, ALPL, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS2, PTPN1, PTPRS, SRC, TNKS, TOP1, XDH 4.97562
[BP] GO:0048856 anatomical structure development ACHE, ADORA1, AKR1B1, ALOX15, ALPL, AXL, BCL2, CA2, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, ESRRB, FLT3, GBA2, HSD11B1, HSD17B2, KDR, MMP9, PIK3CA, PIM1, PPARA, PTGS2, PTPRS, RORC, SRC, TYR 4.9323
[BP] GO:0050896 response to stimulus ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, ALPL, AURKB, AXL, BCL2, CA2, CA9, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, ESR1, ESRRA, F10, F3, FABP3, FABP4, FLT3, HSD11B2, HSD17B2, IGF1R, KDR, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, RORC, SRC, TOP1, TYR 4.92714
[BP] GO:1902531 regulation of intracellular signal transduction ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, F10, F3, FLT3, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, XDH 4.92714
[BP] GO:0023051 regulation of signaling ACHE, ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CA2, CA7, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, F10, F3, FLT3, HCAR2, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, PTPRS, SRC, TNKS, TNKS2, XDH 4.92714
[BP] GO:0009719 response to endogenous stimulus AKR1B1, ALPL, BCL2, CA2, CA9, CSNK2A1, CYP1A2, ESR1, ESRRA, FABP3, FLT3, HSD11B2, IGF1R, MMP2, PPARA, PTGS2, SRC 4.8533
[BP] GO:0032501 multicellular organismal process ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AXL, BCL2, CYP19A1, CYP1A2, CYP1B1, ESR1, ESRRB, F10, F3, FABP4, HSD11B2, HSD17B2, IGF1R, MET, MMP1, MMP2, MMP9, PIK3CA, PIM1, PPARA, PTGS2, RORC, SRC, TNKS2, TOP1, TYR 4.82196
[BP] GO:0048584 positive regulation of response to stimulus ADORA1, AKR1B1, ALOX15, AXL, BCL2, CSNK2A1, CYP1B1, ESRRA, F10, F3, FABP4, FLT3, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, TNKS, TNKS2, XDH 4.81869
[BP] GO:0043069 negative regulation of programmed cell death ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PRKCA, PTGS2, PTPN1, SRC 4.81869
[BP] GO:0006793 phosphorus metabolic process ACHE, ALOX15, ALPL, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS2, PTPN1, PTPRS, SRC, TNKS, TOP1, XDH 4.65768
[BP] GO:0042446 hormone biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.65533
[BP] GO:0034754 cellular hormone metabolic process AKR1B1, CYP19A1, CYP1A1, CYP1B1, ESR1, HSD17B1, HSD17B2 4.50874
[BP] GO:0032787 None ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, GBA2, PPARA, PTGS1, PTGS2 4.50867
[BP] GO:0070887 cellular response to chemical stimulus AKR1B1, ALOX15, ALPL, AXL, BCL2, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, PIK3CA, PTGS2, RORC, SRC 4.42092
[BP] GO:0006468 protein phosphorylation AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIM1, PRKCA, SRC, TNKS, TOP1 4.42092
[BP] GO:0006805 xenobiotic metabolic process CYP1A1, CYP1A2, CYP1B1, CYP2D6, NQO2, PTGS1, RORC 4.3713
[BP] GO:2000145 regulation of cell motility ADORA1, ADORA3, BCL2, CDK6, CYP19A1, CYP1B1, F10, F3, IGF1R, KDR, MET, MMP9, PRKCA, PTGS2, SRC 4.3713
[BP] GO:0032847 regulation of cellular pH reduction BCL2, CA2, CA7 4.35585
[BP] GO:0071310 cellular response to organic substance AKR1B1, ALOX15, ALPL, AXL, BCL2, CDK6, CYP1A1, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, PIK3CA, PTGS2, RORC, SRC 4.3531
[BP] GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PTPN1, SRC 4.3531
[BP] GO:0030522 intracellular receptor signaling pathway ESR1, ESR2, ESRRA, ESRRB, PIM1, PPARA, RORC, SRC 4.30619
[BP] GO:0048583 regulation of response to stimulus ABCB1, ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, ESR1, ESR2, ESRRA, F10, F3, FABP4, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS2, PTPN1, PTPRS, SRC, TNKS, TNKS2, XDH 4.20363
[BP] GO:0042493 response to drug ABCB1, AKR1B1, AXL, BCL2, CA9, CDK6, CYP1A1, CYP1B1, FABP3, HSD11B2, KDR, PTGS2, SRC, TOP1 4.19801
[BP] GO:0043066 negative regulation of apoptotic process ADORA1, AKR1B1, AURKB, AXL, BCL2, CSNK2A1, IGF1R, KDR, MMP9, PIK3CA, PIM1, PRKCA, PTGS2, PTPN1, SRC 4.19801
[BP] GO:0043401 steroid hormone mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 4.02718
[BP] GO:0008284 positive regulation of cell proliferation AKR1B1, BCL2, CDC25B, CDK6, CSNK2A1, ESR1, F3, FLT3, IGF1R, KDR, MMP2, MMP9, PIM1, PRKCA, PTGS2 4.01661
[BP] GO:0016310 phosphorylation AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCA, SRC, TNKS, TOP1 3.99733
[BP] GO:0040012 regulation of locomotion ADORA1, ADORA3, BCL2, CDK6, CYP19A1, CYP1B1, F10, F3, IGF1R, KDR, MET, MMP9, PRKCA, PTGS2, SRC 3.98993
[BP] GO:0051270 regulation of cellular component movement ADORA1, ADORA3, BCL2, CDK6, CYP19A1, CYP1B1, F10, F3, IGF1R, KDR, MET, MMP9, PRKCA, PTGS2, SRC 3.97884
[BP] GO:0030334 regulation of cell migration ADORA1, ADORA3, BCL2, CYP19A1, CYP1B1, F10, F3, IGF1R, KDR, MET, MMP9, PRKCA, PTGS2, SRC 3.97359
[BP] GO:0044092 negative regulation of molecular function ADORA3, AURKB, CSNK2A1, CYP1B1, CYP2D6, ESR1, FABP4, IGF1R, MET, MMP9, PIM1, PPARA, PRKCA, PTGS2, PTPN1, SRC, TNKS 3.94912
[BP] GO:0032879 regulation of localization ABCB1, ACHE, ADORA1, ADORA3, ALOX15, AXL, BCL2, CA2, CA7, CDK6, CSNK2A1, CYP19A1, CYP1B1, F10, F3, HCAR2, IGF1R, KDR, MET, MMP9, PIK3CB, PPARA, PRKCA, PTGS2, PTPN1, SRC 3.94912
[BP] GO:0051896 regulation of protein kinase B signaling AXL, F10, F3, MET, PIK3CA, PIK3CB, SRC, XDH 3.75991
[BP] GO:0009056 catabolic process ACHE, ADORA1, AKR1B10, AOX1, AURKB, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, FABP4, FUT7, GBA2, MMP1, MMP2, MMP9, PIK3CB, SRC, XDH 3.71283
[BP] GO:1901564 organonitrogen compound metabolic process ACHE, AKR1B1, ALPL, AOX1, AURKB, AXL, BCL2, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP2D6, ESR1, F10, F3, FLT3, FUT7, GBA2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIK3CA, PIM1, PPARA, PRKCA, PTGS2, PTPN1, PTPRS, SRC, TNKS, TNKS2, TOP1, TYR, XDH 3.68115
[BP] GO:0051173 positive regulation of nitrogen compound metabolic process ADORA1, ALOX15, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 3.64275
[BP] GO:0051897 positive regulation of protein kinase B signaling AXL, F10, F3, MET, PIK3CA, PIK3CB, SRC 3.64048
[BP] GO:0010562 positive regulation of phosphorus metabolic process ADORA1, ALOX15, BCL2, CDC25B, ESRRB, FABP3, FLT3, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, XDH 3.60934
[BP] GO:0045937 positive regulation of phosphate metabolic process ADORA1, ALOX15, BCL2, CDC25B, ESRRB, FABP3, FLT3, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, XDH 3.60934
[BP] GO:0032846 positive regulation of homeostatic process AURKB, CA2, CA7, HCAR2, PIK3CB, PTGS2, TNKS, TNKS2 3.57145
[BP] GO:0008210 estrogen metabolic process CYP19A1, CYP1B1, HSD17B1, HSD17B2 3.54633
[BP] GO:0042327 positive regulation of phosphorylation ADORA1, ALOX15, BCL2, CDC25B, ESRRB, FLT3, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, XDH 3.49668
[BP] GO:0019752 carboxylic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, GBA2, PIM1, PPARA, PTGS1, PTGS2, TYR 3.49607
[BP] GO:0009755 hormone-mediated signaling pathway ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC, SRC 3.40206
[BP] GO:0015711 organic anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 3.40206
[BP] GO:0031325 positive regulation of cellular metabolic process ADORA1, ALOX15, AURKB, BCL2, CDC25B, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 3.36876
[BP] GO:0010604 positive regulation of macromolecule metabolic process ADORA1, ALOX15, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 3.33108
[BP] GO:0008283 cell proliferation ABCB1, ACHE, AURKB, BCL2, CYP1A1, ESR1, FLT3, MET, PIK3CB, PIM1, SRC, TYR 3.26948
[BP] GO:0009966 regulation of signal transduction ADORA1, AKR1B1, ALOX15, AURKB, AXL, BCL2, CSNK2A1, CYP1B1, ESR1, ESR2, F10, F3, FLT3, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, PTPRS, SRC, TNKS, TNKS2, XDH 3.26948
[BP] GO:0009893 positive regulation of metabolic process ADORA1, ALOX15, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FLT3, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 3.26164
[BP] GO:0030335 positive regulation of cell migration BCL2, F10, F3, IGF1R, KDR, MET, MMP9, PRKCA, PTGS2, SRC 3.22077
[BP] GO:0042325 regulation of phosphorylation ADORA1, ALOX15, BCL2, CDC25B, ESRRB, FABP4, FLT3, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS2, PTPN1, SRC, XDH 3.19826
[BP] GO:0001666 response to hypoxia ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SRC 3.19826
[BP] GO:0007167 enzyme linked receptor protein signaling pathway AXL, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PTPN1, SRC 3.16155
[BP] GO:0036293 response to decreased oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SRC 3.11061
[BP] GO:2000147 positive regulation of cell motility BCL2, F10, F3, IGF1R, KDR, MET, MMP9, PRKCA, PTGS2, SRC 3.10374
[BP] GO:2001225 regulation of chloride transport ABCB1, CA2, CA7 3.09604
[BP] GO:0097267 omega-hydroxylase P450 pathway CYP1A1, CYP1A2, CYP1B1 3.09604
[BP] GO:0048523 negative regulation of cellular process ACHE, ADORA1, ADORA3, AKR1B1, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PPARA, PRKCA, PTGS2, PTPN1, PTPRS, RORC, SRC, TNKS, TNKS2, XDH 3.09604
[BP] GO:0016042 lipid catabolic process ADORA1, AKR1B10, CYP19A1, CYP1A2, CYP1B1, FABP3, FABP4, GBA2 3.09063
[BP] GO:0001934 positive regulation of protein phosphorylation ADORA1, ALOX15, BCL2, CDC25B, FLT3, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, XDH 3.08547
[BP] GO:0043436 oxoacid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, GBA2, PIM1, PPARA, PTGS1, PTGS2, TYR 3.07802
[BP] GO:0019216 regulation of lipid metabolic process ADORA1, CYP1A1, FABP3, FLT3, HCAR2, PPARA, PTGS2, RORC, SRC 3.07588
[BP] GO:0010634 positive regulation of epithelial cell migration KDR, MET, MMP9, PRKCA, PTGS2, SRC 3.07588
[BP] GO:0048519 negative regulation of biological process ACHE, ADORA1, ADORA3, AKR1B1, ALOX15, AURKB, AXL, BCL2, CDK6, CSNK2A1, CYP19A1, CYP1B1, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, FABP3, FABP4, HCAR2, IGF1R, KDR, MET, MMP9, PIK3CA, PIM1, PPARA, PRKCA, PTGS2, PTPN1, PTPRS, RORC, SRC, TNKS, TNKS2, XDH 3.07384
[BP] GO:0048010 vascular endothelial growth factor receptor signaling pathway AXL, KDR, PIK3CA, PIK3CB, SRC 3.06479
[BP] GO:0006694 steroid biosynthetic process AKR1B1, CYP19A1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.06479
[BP] GO:0046777 protein autophosphorylation AURKB, CSNK2A1, FLT3, IGF1R, KDR, PIM1, SRC 3.03622
[BP] GO:0051272 positive regulation of cellular component movement BCL2, F10, F3, IGF1R, KDR, MET, MMP9, PRKCA, PTGS2, SRC 3.03622
[BP] GO:0006082 organic acid metabolic process ALOX15, ALOX5, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FABP3, GBA2, PIM1, PPARA, PTGS1, PTGS2, TYR 3.01351
[BP] GO:0019371 None CBR1, PTGS1, PTGS2 2.99841
[BP] GO:0019220 regulation of phosphate metabolic process ADORA1, ALOX15, BCL2, CDC25B, ESRRB, FABP3, FABP4, FLT3, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS2, PTPN1, SRC, XDH 2.99443
[BP] GO:0051716 cellular response to stimulus AKR1B1, ALOX15, ALPL, AURKB, AXL, BCL2, CA2, CA9, CDK6, CYP1A1, CYP1A2, CYP1B1, ESR1, FABP4, FLT3, IGF1R, KDR, MMP2, MMP9, PIK3CA, PTGS2, PTPN1, RORC, SRC 2.99443
[BP] GO:0048511 rhythmic process AXL, BCL2, CSNK2A1, ESR1, PPARA, RORC, SRC, TOP1 2.97377
[BP] GO:0051174 regulation of phosphorus metabolic process ADORA1, ALOX15, BCL2, CDC25B, ESRRB, FABP3, FABP4, FLT3, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PPARA, PRKCA, PTGS2, PTPN1, SRC, XDH 2.95158
[BP] GO:0040017 positive regulation of locomotion BCL2, F10, F3, IGF1R, KDR, MET, MMP9, PRKCA, PTGS2, SRC 2.92954
[BP] GO:0046456 icosanoid biosynthetic process ALOX15, ALOX5, PTGS1, PTGS2 2.91576
[BP] GO:0070482 response to oxygen levels ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SRC 2.91576
[BP] GO:0080134 regulation of response to stress ABCB1, ADORA1, CDK6, CYP19A1, ESR1, F3, FABP4, IGF1R, MET, MMP2, PPARA, PRKCA, PTGS2, PTPN1, PTPRS, SRC, XDH 2.83157
[BP] GO:0018193 peptidyl-amino acid modification AURKB, AXL, BCL2, CSNK2A1, F10, FLT3, IGF1R, KDR, MET, PRKCA, SRC, TNKS, TOP1 2.8061
[BP] GO:0006703 estrogen biosynthetic process CYP19A1, HSD17B1, HSD17B2 2.80495
[BP] GO:0009115 None AOX1, XDH 2.80054
[BP] GO:0048545 response to steroid hormone ALPL, BCL2, CA2, FLT3, HSD11B2, PTGS2, SRC 2.78853
[BP] GO:1901701 cellular response to oxygen-containing compound AKR1B1, AXL, CDK6, CYP1B1, ESR1, IGF1R, MMP2, MMP9, PIK3CA, PTGS2, RORC, SRC 2.78278
[BP] GO:0071248 cellular response to metal ion ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.7395
[BP] GO:0060065 uterus development CYP19A1, ESR1, SRC 2.72142
[BP] GO:1901615 organic hydroxy compound metabolic process AKR1B1, AKR1B10, ALOX15, BCL2, CYP19A1, CYP1A1, CYP1B1, GBA2, TYR 2.71085
[BP] GO:0010038 response to metal ion ALOX15, BCL2, CA2, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.66843
[BP] GO:0065009 regulation of molecular function ABCB1, ADORA1, ADORA3, AURKB, BCL2, CDC25B, CSNK2A1, CYP1B1, CYP2D6, ESR1, ESR2, F3, FABP4, FLT3, IGF1R, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS2, PTPN1, SRC, TNKS, XDH 2.66843
[BP] GO:0031960 response to corticosteroid ALPL, BCL2, FLT3, HSD11B2, PTGS2, SRC 2.6401
[BP] GO:0002682 regulation of immune system process ADORA1, ALOX15, AXL, BCL2, CA2, CDK6, CYP19A1, ESR1, ESRRA, HCAR2, MMP2, PIK3CA, PIK3CB, PRKCA, PTPN1, PTPRS, SRC 2.62452
[BP] GO:0001932 regulation of protein phosphorylation ADORA1, ALOX15, BCL2, CDC25B, FABP4, FLT3, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, XDH 2.57969
[BP] GO:0006820 anion transport ABCB1, CA1, CA12, CA14, CA2, CA4, CA7, CA9, FABP3, PPARA 2.5782
[BP] GO:2001243 negative regulation of intrinsic apoptotic signaling pathway BCL2, MMP9, PTGS2, PTPN1, SRC 2.57597
[BP] GO:0006367 transcription initiation from RNA polymerase II promoter ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.57386
[BP] GO:2000811 negative regulation of anoikis BCL2, PIK3CA, SRC 2.56734
[BP] GO:0030540 female genitalia development AXL, CYP19A1, ESR1 2.56734
[BP] GO:0019372 lipoxygenase pathway ALOX15, ALOX5, PTGS2 2.56734
[BP] GO:0022900 electron transport chain AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 2.55259
[BP] GO:0018105 peptidyl-serine phosphorylation AURKB, BCL2, PRKCA, SRC, TNKS, TOP1 2.50994
[BP] GO:1904355 positive regulation of telomere capping AURKB, TNKS, TNKS2 2.49093
[BP] GO:0006979 response to oxidative stress AKR1B1, AXL, BCL2, CYP1B1, MMP9, PTGS1, PTGS2, SRC 2.47962
[BP] GO:0051098 regulation of binding AURKB, BCL2, CYP2D6, MET, MMP9, PPARA, SRC, TNKS 2.47962
[BP] GO:0001952 regulation of cell-matrix adhesion BCL2, CDK6, KDR, PIK3CB, SRC 2.42905
[BP] GO:0016137 None AKR1B1, AKR1B10, GBA2 2.42188
[BP] GO:0071241 cellular response to inorganic substance ALOX15, CYP1A1, CYP1A2, FABP4, MMP9, PTGS2 2.42188
[BP] GO:0071407 cellular response to organic cyclic compound ALPL, CYP1A1, CYP1B1, ESR1, FLT3, PTGS2, RORC, SRC 2.41732
[BP] GO:0001525 angiogenesis CYP1B1, KDR, MMP2, PIK3CA, PIK3CB, PRKCA, PTGS2 2.4135
[BP] GO:0000302 response to reactive oxygen species AKR1B1, AXL, BCL2, CYP1B1, MMP9, SRC 2.40027
[BP] GO:0046110 None AOX1, XDH 2.39601
[BP] GO:0032849 positive regulation of cellular pH reduction CA2, CA7 2.39601
[BP] GO:0032210 regulation of telomere maintenance via telomerase AURKB, SRC, TNKS, TNKS2 2.39102
[BP] GO:0006721 terpenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6 2.3711
[BP] GO:0051900 regulation of mitochondrial depolarization BCL2, KDR, SRC 2.36976
[BP] GO:0051247 positive regulation of protein metabolic process ADORA1, ALOX15, BCL2, CDC25B, CSNK2A1, ESR1, F3, FLT3, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, XDH 2.36212
[BP] GO:0042542 response to hydrogen peroxide AKR1B1, AXL, BCL2, CYP1B1, SRC 2.36212
[BP] GO:0034614 cellular response to reactive oxygen species AKR1B1, AXL, CYP1B1, MMP9, SRC 2.36212
[BP] GO:0009611 response to wounding ACHE, ADORA3, ALOX15, BCL2, CYP1A1, PPARA 2.35458
[BP] GO:0007166 cell surface receptor signaling pathway ADORA1, ADORA3, AXL, BCL2, CA1, CSNK2A1, F3, FLT3, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PRKCA, PTPN1, SRC, TNKS, TNKS2 2.33267
[BP] GO:0030168 platelet activation AXL, PIK3CA, PIK3CB, PRKCA, SRC 2.33207
[BP] GO:0018209 peptidyl-serine modification AURKB, BCL2, PRKCA, SRC, TNKS, TOP1 2.29997
[BP] GO:0003006 developmental process involved in reproduction ALPL, AXL, BCL2, CDC25B, CYP19A1, ESR1, ESRRB, HSD17B2, PTGS2, SRC 2.29783
[BP] GO:0018108 peptidyl-tyrosine phosphorylation AXL, FLT3, IGF1R, KDR, MET, SRC 2.27977
[BP] GO:0001503 ossification ALOX15, ALPL, BCL2, MMP2, MMP9 2.27259
[BP] GO:0009892 negative regulation of metabolic process ADORA1, AURKB, BCL2, CSNK2A1, CYP2D6, ESR1, ESR2, ESRRA, FABP4, HCAR2, IGF1R, KDR, MET, MMP9, PIK3CA, PPARA, PRKCA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, XDH 2.27259
[BP] GO:0048585 negative regulation of response to stimulus ADORA1, ALOX15, BCL2, CDK6, CYP19A1, ESR1, ESR2, IGF1R, MET, MMP9, PPARA, PTGS2, PTPN1, PTPRS, SRC, XDH 2.27259
[BP] GO:0071498 cellular response to fluid shear stress CA2, PTGS2, SRC 2.27259
[BP] GO:0019373 epoxygenase P450 pathway CYP1A1, CYP1A2, CYP1B1 2.27259
[BP] GO:0010810 regulation of cell-substrate adhesion ALOX15, BCL2, CDK6, KDR, PIK3CB, SRC 2.26558
[BP] GO:0018212 peptidyl-tyrosine modification AXL, FLT3, IGF1R, KDR, MET, SRC 2.25469
[BP] GO:0034502 protein localization to chromosome AURKB, ESR1, TNKS, TNKS2 2.25458
[BP] GO:1904356 regulation of telomere maintenance via telomere lengthening AURKB, SRC, TNKS, TNKS2 2.22768
[BP] GO:0030520 intracellular estrogen receptor signaling pathway ESR1, ESR2, SRC 2.21954
[BP] GO:0009987 cellular process ABCB1, ACHE, ADORA1, ADORA3, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA12, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, FUT7, GBA2, HCAR2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SRC, TNKS, TNKS2, TOP1, TUBB3, TYR, XDH 2.21441
[BP] GO:0035690 cellular response to drug AKR1B1, AXL, CDK6, CYP1B1, KDR, PTGS2, SRC 2.21417
[BP] GO:0022414 reproductive process AKR1B1, ALPL, AXL, BCL2, CDC25B, CYP19A1, CYP1A1, ESR1, ESRRB, HSD11B2, HSD17B2, MMP2, MMP9, PTGS2, SRC 2.16925
[BP] GO:2000209 regulation of anoikis BCL2, PIK3CA, SRC 2.16925
[BP] GO:0009404 toxin metabolic process CYP1A1, CYP1A2, CYP1B1 2.16925
[BP] GO:0033031 positive regulation of neutrophil apoptotic process HCAR2, PIK3CB 2.16837
[BP] GO:0070213 None TNKS, TNKS2 2.16837
[BP] GO:0006145 None AOX1, XDH 2.16837
[BP] GO:0018894 dibenzo-p-dioxin metabolic process CYP1A1, CYP1A2 2.16837
[BP] GO:0042592 homeostatic process ADORA1, AKR1B1, AXL, BCL2, CA12, CA2, CA7, ESR1, FABP3, FABP4, FLT3, MET, PIK3CA, PIK3CB, SRC 2.1678
[BP] GO:0045834 positive regulation of lipid metabolic process FABP3, FLT3, PPARA, PTGS2, SRC 2.15439
[BP] GO:0032270 positive regulation of cellular protein metabolic process ADORA1, ALOX15, BCL2, CDC25B, ESR1, F3, FLT3, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, XDH 2.15439
[BP] GO:2000573 positive regulation of DNA biosynthetic process AURKB, SRC, TNKS, TNKS2 2.14485
[BP] GO:0031401 positive regulation of protein modification process ADORA1, ALOX15, BCL2, CDC25B, FLT3, KDR, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, XDH 2.14316
[BP] GO:0043410 positive regulation of MAPK cascade ADORA1, ALOX15, FLT3, KDR, PIK3CB, PRKCA, PTPN1, SRC, XDH 2.14187
[BP] GO:1903409 reactive oxygen species biosynthetic process CYP1A1, CYP1A2, CYP1B1 2.13391
[BP] GO:0006720 isoprenoid metabolic process AKR1B10, CYP1A1, CYP1A2, CYP1B1, CYP2D6 2.13307
[BP] GO:0009894 regulation of catabolic process ADORA1, BCL2, CSNK2A1, ESRRB, HCAR2, KDR, MET, PIK3CA, PIK3CB, PPARA, PRKCA, PTPN1 2.11619
[BP] GO:1902532 negative regulation of intracellular signal transduction BCL2, ESR1, IGF1R, MET, MMP9, PTGS2, PTPN1, SRC, XDH 2.11194
[BP] GO:0009636 response to toxic substance AKR1B1, ALPL, AXL, BCL2, CYP1A1, CYP1B1, KDR, SRC 2.10823
[BP] GO:0006352 DNA-templated transcription, initiation ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 2.1082
[BP] GO:0043393 regulation of protein binding AURKB, BCL2, MET, MMP9, PPARA, SRC 2.1082
[BP] GO:0046486 glycerolipid metabolic process ACHE, ALOX15, CSNK2A1, FABP3, FABP4, MET, PIK3CA, PIK3CB 2.10165
[BP] GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process CSNK2A1, F3, MMP9, PTGS2, SRC, XDH 2.10165
[BP] GO:0032101 regulation of response to external stimulus ADORA1, CYP19A1, ESR1, F3, FABP4, KDR, MET, PPARA, PRKCA, PTGS2, PTPRS 2.08194
[BP] GO:2000021 regulation of ion homeostasis ADORA1, BCL2, CA2, CA7, KDR, SRC 2.08194
[BP] GO:0017144 drug metabolic process ACHE, AKR1B1, AKR1B10, AOX1, CBR1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 2.05773
[BP] GO:0044093 positive regulation of molecular function ABCB1, ADORA1, AURKB, BCL2, CDC25B, ESR1, ESR2, F3, FLT3, MET, MMP9, PIK3CA, PIK3CB, PTPN1, SRC, TNKS, XDH 2.05664
[BP] GO:1904353 regulation of telomere capping AURKB, TNKS, TNKS2 2.05452
[BP] GO:0050790 regulation of catalytic activity ADORA1, ADORA3, AURKB, BCL2, CDC25B, CSNK2A1, ESR1, F3, FABP4, FLT3, IGF1R, MMP9, PIK3CA, PIK3CB, PRKCA, PTGS2, PTPN1, SRC, TNKS, XDH 2.05379
[BP] GO:0051239 regulation of multicellular organismal process ADORA1, ADORA3, AXL, BCL2, CA2, CDK6, CYP1B1, ESR1, ESRRA, ESRRB, F3, HCAR2, KDR, MET, MMP9, PIK3CA, PIM1, PRKCA, PTGS2, PTPRS, SRC, TNKS2, XDH 2.05243
[BP] GO:0019222 regulation of metabolic process ACHE, ADORA1, ADORA3, ALOX15, AURKB, BCL2, CA9, CDC25B, CDK6, CSNK2A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, HCAR2, IGF1R, KDR, MET, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS2, PTPN1, RORC, SRC, TNKS, TNKS2, TOP1, XDH 2.03321
[BP] GO:0010632 regulation of epithelial cell migration KDR, MET, MMP9, PRKCA, PTGS2, SRC 2.01791
[BP] GO:0048869 cellular developmental process ACHE, ALPL, AXL, BCL2, CBR1, CDC25B, CDK6, CYP1A1, ESR1, ESRRB, FABP4, FLT3, FUT7, GBA2, KDR, MET, MMP2, MMP9, PTGS2, PTPRS, RORC, SRC 2.01778
[BP] GO:1904357 None SRC, TNKS, TNKS2 2.01744
[BP] GO:0007165 signal transduction ADORA1, ADORA3, AKR1B1, AXL, BCL2, CA1, CA2, CDK6, CSNK2A1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, IGF1R, KDR, MET, MMP2, MMP9, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTPN1, RORC, SRC, TNKS, TNKS2 2.00956
[BP] GO:0043696 None CDK6, ESRRB 2.00956
[BP] GO:0043697 None CDK6, ESRRB 2.00956
[BP] GO:0010641 None F3, SRC 2.00956
[BP] GO:0007598 None F10, F3 2.00956
[BP] GO:0030155 regulation of cell adhesion ALOX15, BCL2, CDK6, CYP1B1, KDR, PIK3CA, PIK3CB, PPARA, PRKCA, SRC 2.00596
[CC] GO:0044444 cytoplasmic part ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, AURKB, BCL2, CA1, CA2, CA4, CA7, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, ESR2, F10, FABP3, FABP4, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, KDR, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS1, PTGS2, PTPN1, PTPRS, SRC, TNKS, TNKS2, TOP1, TYR, XDH 2.91576
[CC] GO:0016020 membrane ABCB1, ACHE, ADORA1, ADORA3, ALOX15, ALOX5, ALPL, AXL, BCL2, CA12, CA14, CA2, CA4, CA9, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, F10, F3, FLT3, FUT7, GBA2, HCAR2, HSD11B1, HSD11B2, HSD17B2, IGF1R, KDR, MET, MMP2, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS1, PTGS2, PTPN1, PTPRS, SRC, TNKS, TNKS2, TYR 2.83157
[CC] GO:0044432 endoplasmic reticulum part BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, F10, FLT3, GBA2, HSD11B1, HSD11B2, HSD17B2, PTGS1, PTGS2, PTPN1 2.36335
[CC] GO:0031233 None CA4, F10, F3 2.31877
[CC] GO:0043227 membrane-bounded organelle ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALPL, AOX1, AURKB, AXL, BCL2, CA1, CA2, CA4, CBR1, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, F3, FABP3, FABP4, FLT3, FUT7, GBA2, IGF1R, KDR, MMP2, MMP9, NQO2, PIK3CB, PIM1, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SRC, TNKS, TNKS2, TOP1, TUBB3, TYR, XDH 2.2959
[CC] GO:0005789 endoplasmic reticulum membrane BCL2, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, GBA2, HSD11B1, HSD11B2, HSD17B2, PTGS1, PTGS2 2.1068
[CC] GO:0005783 None ADORA1, BCL2, CA4, CYP19A1, CYP2D6, FLT3, GBA2, KDR, PRKCA, PTGS2, PTPN1, XDH 2.02536
[MF] GO:0003824 catalytic activity ABCB1, ACHE, ADORA1, AKR1B1, AKR1B10, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CBR1, CDC25B, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, F10, F3, FLT3, FUT7, GBA2, HSD11B1, HSD11B2, HSD17B1, HSD17B2, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PRKCA, PTGS1, PTGS2, PTPN1, PTPRS, SRC, TNKS, TNKS2, TOP1, TUBB3, TYR, XDH 15.2236
[MF] GO:0046914 transition metal ion binding ALOX15, ALOX5, AOX1, CA1, CA12, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, NQO2, PIM1, PPARA, PRKCA, PTPN1, RORC, TNKS, TYR, XDH 15.2236
[MF] GO:0043167 ion binding ABCB1, ACHE, ALOX15, ALOX5, ALPL, AOX1, AURKB, AXL, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MET, MMP1, MMP2, MMP9, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, PTPRS, RORC, SRC, TNKS, TNKS2, TOP1, TUBB3, TYR, XDH 12.5969
[MF] GO:0004089 carbonate dehydratase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 9.82778
[MF] GO:0016491 oxidoreductase activity AKR1B1, AKR1B10, ALOX15, ALOX5, AOX1, CBR1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, HSD11B1, HSD11B2, HSD17B1, HSD17B2, NQO2, PTGS1, PTGS2, TYR, XDH 8.76415
[MF] GO:0008270 zinc ion binding CA1, CA12, CA2, CA4, CA7, CA9, ESR1, ESR2, ESRRA, ESRRB, MMP1, MMP2, MMP9, NQO2, PPARA, PRKCA, PTPN1, RORC, TNKS 7.41259
[MF] GO:0016836 hydro-lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 6.15601
[MF] GO:0016614 oxidoreductase activity, acting on CH-OH group of donors AKR1B1, AKR1B10, AOX1, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2, XDH 6.06987
[MF] GO:0043169 cation binding ACHE, ALOX15, ALOX5, ALPL, AOX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, F10, MMP1, MMP2, MMP9, NQO2, PIM1, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, RORC, TNKS, TNKS2, TYR, XDH 5.96065
[MF] GO:0046872 metal ion binding ALOX15, ALOX5, ALPL, AOX1, AURKB, CA1, CA12, CA14, CA2, CA4, CA7, CA9, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, ESR1, ESR2, ESRRA, ESRRB, F10, MMP1, MMP2, MMP9, NQO2, PIM1, PPARA, PRKCA, PTGS1, PTGS2, PTPN1, RORC, TNKS, TNKS2, TYR, XDH 5.67197
[MF] GO:0005506 iron ion binding ALOX15, ALOX5, AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, XDH 5.57091
[MF] GO:0016835 carbon-oxygen lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 5.42895
[MF] GO:0048037 cofactor binding AOX1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, HSD11B2, HSD17B1, NQO2, PTGS1, PTGS2, SRC, XDH 5.25688
[MF] GO:0008144 drug binding ABCB1, ACHE, AURKB, AXL, CDK6, CSNK2A1, CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, FLT3, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, PPARA, PRKCA, SRC, TOP1 5.25068
[MF] GO:0070330 aromatase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 5.20434
[MF] GO:0020037 heme binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2, SRC 5.16823
[MF] GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.11865
[MF] GO:0004879 nuclear receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 5.11865
[MF] GO:0005496 steroid binding ESR1, ESR2, ESRRA, ESRRB, HSD11B2, HSD17B1, RORC 5.07203
[MF] GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 4.97562
[MF] GO:0046906 tetrapyrrole binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2, SRC 4.97562
[MF] GO:0003707 steroid hormone receptor activity ESR1, ESR2, ESRRA, ESRRB, PPARA, RORC 4.72687
[MF] GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, PTGS1, PTGS2, TYR 4.65533
[MF] GO:0008289 lipid binding ALOX15, AXL, ESR1, ESR2, ESRRA, ESRRB, F10, F3, FABP3, FABP4, HSD11B2, HSD17B1, PPARA, RORC 4.57773
[MF] GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor AKR1B1, AKR1B10, CBR1, HSD11B1, HSD11B2, HSD17B1, HSD17B2 4.27035
[MF] GO:0004672 protein kinase activity AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIM1, PRKCA, SRC, TOP1 3.98993
[MF] GO:0019825 oxygen binding CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6 3.93538
[MF] GO:0016773 phosphotransferase activity, alcohol group as acceptor AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCA, SRC, TOP1 3.91055
[MF] GO:0043168 anion binding ABCB1, ALOX15, AOX1, AURKB, AXL, CDK6, CSNK2A1, F10, F3, FABP3, FABP4, FLT3, HSD17B1, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, PRKCA, PTPRS, SRC, TOP1, TUBB3, XDH 3.68803
[MF] GO:0004497 monooxygenase activity CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, TYR 3.64766
[MF] GO:0016301 kinase activity AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCA, SRC, TOP1 3.50051
[MF] GO:0036094 small molecule binding ABCB1, ADORA1, AOX1, AURKB, AXL, CDK6, CSNK2A1, FABP3, FABP4, FLT3, HSD11B2, HSD17B1, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, PRKCA, SRC, TOP1, TUBB3, XDH 3.48652
[MF] GO:0009055 electron transfer activity AKR1B1, AOX1, CYP19A1, CYP1A2, NQO2, XDH 3.36962
[MF] GO:0033764 steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.36466
[MF] GO:0004714 transmembrane receptor protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET 3.31931
[MF] GO:0016229 steroid dehydrogenase activity HSD11B1, HSD11B2, HSD17B1, HSD17B2 3.25611
[MF] GO:0016829 lyase activity CA1, CA12, CA14, CA2, CA4, CA7, CA9 3.16982
[MF] GO:0043560 insulin receptor substrate binding IGF1R, PIK3CA, PIK3CB 2.99841
[MF] GO:0000166 nucleotide binding ABCB1, AOX1, AURKB, AXL, CDK6, CSNK2A1, FLT3, HSD11B2, HSD17B1, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, PRKCA, SRC, TOP1, TUBB3, XDH 2.94941
[MF] GO:1901265 nucleoside phosphate binding ABCB1, AOX1, AURKB, AXL, CDK6, CSNK2A1, FLT3, HSD11B2, HSD17B1, IGF1R, KDR, MET, NQO2, PIK3CA, PIK3CB, PIM1, PRKCA, SRC, TOP1, TUBB3, XDH 2.94893
[MF] GO:0019199 transmembrane receptor protein kinase activity AXL, FLT3, IGF1R, KDR, MET 2.91221
[MF] GO:0016772 transferase activity, transferring phosphorus-containing groups AURKB, AXL, CDK6, CSNK2A1, FLT3, IGF1R, KDR, MET, PIK3CA, PIK3CB, PIM1, PRKCA, SRC, TOP1 2.82812
[MF] GO:0004666 prostaglandin-endoperoxide synthase activity PTGS1, PTGS2 2.80054
[MF] GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding ESR1, ESR2 2.80054
[MF] GO:0003845 None HSD11B1, HSD11B2 2.80054
[MF] GO:0016903 None AKR1B1, AKR1B10, AOX1, XDH 2.66031
[MF] GO:0050473 arachidonate 15-lipoxygenase activity ALOX15, PTGS2 2.39601
[MF] GO:0004713 protein tyrosine kinase activity AXL, FLT3, IGF1R, KDR, MET, SRC 2.33207
[MF] GO:0140096 catalytic activity, acting on a protein AURKB, AXL, CDC25B, CDK6, CSNK2A1, F10, F3, FLT3, IGF1R, KDR, MET, MMP1, MMP2, MMP9, PIK3CA, PIM1, PRKCA, PTPN1, PTPRS, SRC, TOP1 2.31237
[MF] GO:0034056 estrogen response element binding ESR1, ESR2 2.16837
[MF] GO:0038023 signaling receptor activity ADORA1, ADORA3, AXL, ESR1, ESR2, ESRRA, ESRRB, F3, FLT3, HCAR2, IGF1R, KDR, MET, PPARA, RORC 2.13364
[MF] GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ALOX15, ALOX5, PTGS2 2.05452
[MF] GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen ALOX15, ALOX5, PTGS2 2.01744
[MF] GO:0030284 estrogen receptor activity ESR1, ESR2 2.00956


KEGG Pathways Associated to Targeted Human Proteins

KEGG Pathway ID Enriched Genes Log10 Adjusted P-value
Ovarian steroidogenesis_Homo sapiens_hsa04913 ALOX5, HSD17B1, HSD17B2, CYP1A1, CYP1B1, PTGS2, CYP19A1, IGF1R 9.2752
Nitrogen metabolism_Homo sapiens_hsa00910 CA12, CA1, CA2, CA4, CA7, CA9, CA14 10.869
Steroid hormone biosynthesis_Homo sapiens_hsa00140 HSD11B1, HSD11B2, HSD17B1, HSD17B2, CYP1A2, CYP1A1, CYP1B1, CYP19A1 8.908
Proteoglycans in cancer_Homo sapiens_hsa05205 PIK3CA, SRC, MMP2, KDR, PRKCA, PIK3CB, MMP9, MET, ESR1, IGF1R 7.1031
Pathways in cancer_Homo sapiens_hsa05200 CDK6, PIK3CA, FLT3, MMP1, MMP2, BCL2, PRKCA, PIK3CB, PTGS2, MMP9, MET, IGF1R 6.5493
MicroRNAs in cancer_Homo sapiens_hsa05206 CDK6, ABCB1, PIK3CA, BCL2, PIM1, CYP1B1, PRKCA, PTGS2, MMP9, MET, CDC25B 6.7359
Metabolic pathways_Homo sapiens_hsa01100 CBR1, ALOX15, AKR1B1, PTGS2, TYR, GBA2, CYP19A1, PTGS1, HSD11B1, FUT7, AKR1B10, ALOX5, HSD17B1, HSD17B2, CYP1A2, CYP1A1, AOX1, ALPL, XDH 6.2559
AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 PIK3CA, MMP2, BCL2, PIM1, PRKCA, PIK3CB, F3 6.0215
Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 FABP4, PIK3CA, ADORA1, PIK3CB, PTGS2, PTGS1 6.0948
Estrogen signaling pathway_Homo sapiens_hsa04915 PIK3CA, SRC, MMP2, PIK3CB, MMP9, ESR1, ESR2 6.036
VEGF signaling pathway_Homo sapiens_hsa04370 PIK3CA, SRC, KDR, PRKCA, PIK3CB, PTGS2 6.0059
Focal adhesion_Homo sapiens_hsa04510 PIK3CA, SRC, KDR, BCL2, PRKCA, PIK3CB, MET, IGF1R 5.2534
Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 HSD11B1, CBR1, CYP2D6, CYP1A2, CYP1A1, CYP1B1 5.5712
Hepatitis B_Homo sapiens_hsa05161 CDK6, PIK3CA, SRC, BCL2, PRKCA, PIK3CB, MMP9 5.1015
Chemical carcinogenesis_Homo sapiens_hsa05204 HSD11B1, CBR1, CYP1A2, CYP1A1, CYP1B1, PTGS2 5.3034
Glioma_Homo sapiens_hsa05214 CDK6, PIK3CA, PRKCA, PIK3CB, IGF1R 4.5575
Serotonergic synapse_Homo sapiens_hsa04726 CYP2D6, ALOX5, ALOX15, PRKCA, PTGS2, PTGS1 4.6205
Arachidonic acid metabolism_Homo sapiens_hsa00590 CBR1, ALOX5, ALOX15, PTGS2, PTGS1 4.6205
Rap1 signaling pathway_Homo sapiens_hsa04015 PIK3CA, SRC, KDR, PRKCA, PIK3CB, MET, IGF1R 4.2246
Sphingolipid signaling pathway_Homo sapiens_hsa04071 PIK3CA, ADORA3, BCL2, ADORA1, PRKCA, PIK3CB 4.4944
Melanoma_Homo sapiens_hsa05218 CDK6, PIK3CA, PIK3CB, MET, IGF1R 4.4126
Prolactin signaling pathway_Homo sapiens_hsa04917 PIK3CA, SRC, PIK3CB, ESR1, ESR2 4.4037
PI3K-Akt signaling pathway_Homo sapiens_hsa04151 CDK6, PIK3CA, KDR, BCL2, PRKCA, PIK3CB, MET, IGF1R 3.8745
Adherens junction_Homo sapiens_hsa04520 PTPN1, CSNK2A1, SRC, MET, IGF1R 4.365
Small cell lung cancer_Homo sapiens_hsa05222 CDK6, PIK3CA, BCL2, PIK3CB, PTGS2 4.1294
Cholinergic synapse_Homo sapiens_hsa04725 ACHE, PIK3CA, BCL2, PRKCA, PIK3CB 3.6469
HIF-1 signaling pathway_Homo sapiens_hsa04066 PIK3CA, BCL2, PRKCA, PIK3CB, IGF1R 3.7833
Thyroid hormone signaling pathway_Homo sapiens_hsa04919 PIK3CA, SRC, PRKCA, PIK3CB, ESR1 3.5691
Ras signaling pathway_Homo sapiens_hsa04014 PIK3CA, KDR, PRKCA, PIK3CB, MET, IGF1R 3.2335
Leukocyte transendothelial migration_Homo sapiens_hsa04670 PIK3CA, MMP2, PRKCA, PIK3CB, MMP9 3.5691
Non-small cell lung cancer_Homo sapiens_hsa05223 CDK6, PIK3CA, PRKCA, PIK3CB 3.6469
Jak-STAT signaling pathway_Homo sapiens_hsa04630 PIK3CA, BCL2, PIM1, AOX1, PIK3CB 3.0532
Oxytocin signaling pathway_Homo sapiens_hsa04921 PIK3CA, SRC, PRKCA, PIK3CB, PTGS2 3.0532
Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 HSD11B2, PIK3CA, PRKCA, PIK3CB 4.1663
Acute myeloid leukemia_Homo sapiens_hsa05221 PIK3CA, FLT3, PIM1, PIK3CB 3.63
Tryptophan metabolism_Homo sapiens_hsa00380 CYP1A2, CYP1A1, AOX1, CYP1B1 4.1394
Central carbon metabolism in cancer_Homo sapiens_hsa05230 PIK3CA, FLT3, PIK3CB, MET 3.3923
Bladder cancer_Homo sapiens_hsa05219 SRC, MMP1, MMP2, MMP9 4.1294
Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 PIK3CA, SRC, PRKCA, PIK3CB 2.863
Prostate cancer_Homo sapiens_hsa05215 PIK3CA, BCL2, PIK3CB, IGF1R 3.0034
ErbB signaling pathway_Homo sapiens_hsa04012 PIK3CA, SRC, PRKCA, PIK3CB 3.0311
Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 PIK3CA, PIK3CB, CDC25B, IGF1R 2.863
cAMP signaling pathway_Homo sapiens_hsa04024 HCAR2, PIK3CA, ADORA1, PIK3CB, PPARA 2.6621
Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 PIK3CA, SRC, PIK3CB, MET 3.182
TNF signaling pathway_Homo sapiens_hsa04668 PIK3CA, PIK3CB, PTGS2, MMP9 2.6919
Insulin resistance_Homo sapiens_hsa04931 PTPN1, PIK3CA, PIK3CB, PPARA 2.6975
PPAR signaling pathway_Homo sapiens_hsa03320 FABP3, FABP4, MMP1, PPARA 3.3546
Platelet activation_Homo sapiens_hsa04611 PIK3CA, SRC, PIK3CB, PTGS1 2.5499
Toxoplasmosis_Homo sapiens_hsa05145 PIK3CA, ALOX5, BCL2, PIK3CB 2.5953
Measles_Homo sapiens_hsa05162 CDK6, CSNK2A1, PIK3CA, PIK3CB 2.3917
Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 PIK3CA, ESRRB, PIK3CB, IGF1R 2.3547
Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 PIK3CA, BCL2, PRKCA, PIK3CB 2.3188
cGMP-PKG signaling pathway_Homo sapiens_hsa04022 PIK3CA, ADORA3, ADORA1, PIK3CB 2.1494
Transcriptional misregulation in cancer_Homo sapiens_hsa05202 FLT3, MMP9, MET, IGF1R 2.0505
Epstein-Barr virus infection_Homo sapiens_hsa05169 CSNK2A1, PIK3CA, BCL2, PIK3CB 1.9367
mTOR signaling pathway_Homo sapiens_hsa04150 PIK3CA, PRKCA, PIK3CB 2.4147
Viral carcinogenesis_Homo sapiens_hsa05203 CDK6, PIK3CA, SRC, PIK3CB 1.9255
Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 PIK3CA, PIK3CB, IGF1R 2.3583
GnRH signaling pathway_Homo sapiens_hsa04912 SRC, MMP2, PRKCA 2.016
Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 PIK3CA, PRKCA, PIK3CB 2.3208
Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 PIK3CA, PRKCA, PIK3CB 2.0023
Colorectal cancer_Homo sapiens_hsa05210 PIK3CA, BCL2, PIK3CB 2.3901
Chronic myeloid leukemia_Homo sapiens_hsa05220 CDK6, PIK3CA, PIK3CB 2.2539
Pancreatic cancer_Homo sapiens_hsa05212 CDK6, PIK3CA, PIK3CB 2.3508
Longevity regulating pathway - mammal_Homo sapiens_hsa04211 PIK3CA, PIK3CB, IGF1R 1.9957
Gap junction_Homo sapiens_hsa04540 SRC, TUBB3, PRKCA 2.0505
Renal cell carcinoma_Homo sapiens_hsa05211 PIK3CA, PIK3CB, MET 2.3508
Choline metabolism in cancer_Homo sapiens_hsa05231 PIK3CA, PRKCA, PIK3CB 1.9385
Phosphatidylinositol signaling system_Homo sapiens_hsa04070 PIK3CA, PRKCA, PIK3CB 1.9574
Endocytosis_Homo sapiens_hsa04144 SRC, KDR, MET, IGF1R 1.643
NF-kappa B signaling pathway_Homo sapiens_hsa04064 CSNK2A1, BCL2, PTGS2 2.0023
Amoebiasis_Homo sapiens_hsa05146 PIK3CA, PRKCA, PIK3CB 1.9446
Neurotrophin signaling pathway_Homo sapiens_hsa04722 PIK3CA, BCL2, PIK3CB 1.7652
Retinol metabolism_Homo sapiens_hsa00830 CYP1A2, CYP1A1, AOX1 2.3547
FoxO signaling pathway_Homo sapiens_hsa04068 PIK3CA, PIK3CB, IGF1R 1.6649
AMPK signaling pathway_Homo sapiens_hsa04152 PIK3CA, PIK3CB, IGF1R 1.7319
Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 PIK3CA, PRKCA, PIK3CB 1.6546
Hepatitis C_Homo sapiens_hsa05160 PIK3CA, PIK3CB, PPARA 1.6649
Herpes simplex infection_Homo sapiens_hsa05168 CSNK2A1 0.3243
Apoptosis_Homo sapiens_hsa04210 PIK3CA, BCL2, PIK3CB 1.6394
Purine metabolism_Homo sapiens_hsa00230 XDH 0.3347
Calcium signaling pathway_Homo sapiens_hsa04020 PRKCA 0.3302
Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 BCL2 0.3451
Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 CYP2D6, CYP1A2, AOX1 2.317
Insulin signaling pathway_Homo sapiens_hsa04910 PTPN1, PIK3CA, PIK3CB 1.643
Phospholipase D signaling pathway_Homo sapiens_hsa04072 PIK3CA, PRKCA, PIK3CB 1.6114
Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 PIK3CA, PIK3CB, PPARA 1.567
Phagosome_Homo sapiens_hsa04145 TUBB3 0.3726
Tight junction_Homo sapiens_hsa04530 CSNK2A1, SRC, PRKCA 1.643
Influenza A_Homo sapiens_hsa05164 PIK3CA, PRKCA, PIK3CB 1.4199
Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 ADORA3, ADORA1 0.5538
Axon guidance_Homo sapiens_hsa04360 MET 0.4326
Regulation of actin cytoskeleton_Homo sapiens_hsa04810 PIK3CA, SRC, PIK3CB 1.2346
Dopaminergic synapse_Homo sapiens_hsa04728 PRKCA 0.4298
Oocyte meiosis_Homo sapiens_hsa04114 IGF1R 0.4411
MAPK signaling pathway_Homo sapiens_hsa04010 PRKCA, CDC25B 0.5941
HTLV-I infection_Homo sapiens_hsa05166 PIK3CA, PIK3CB 0.5926
Vascular smooth muscle contraction_Homo sapiens_hsa04270 PRKCA 0.447
Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 FLT3, KDR, MET 1.0462
Glutamatergic synapse_Homo sapiens_hsa04724 PRKCA 0.4623
Tuberculosis_Homo sapiens_hsa05152 SRC, BCL2 0.7857
Chemokine signaling pathway_Homo sapiens_hsa04062 PIK3CA, SRC, PIK3CB 1.3685
Wnt signaling pathway_Homo sapiens_hsa04310 CSNK2A1, PRKCA 0.9285
Glucagon signaling pathway_Homo sapiens_hsa04922 PPARA 0.5032
Osteoclast differentiation_Homo sapiens_hsa04380 PIK3CA, PIK3CB 0.9755
Glycerophospholipid metabolism_Homo sapiens_hsa00564 ACHE 0.5227
Circadian entrainment_Homo sapiens_hsa04713 PRKCA 0.5227
Cell cycle_Homo sapiens_hsa04110 CDK6, CDC25B 1.019
Rheumatoid arthritis_Homo sapiens_hsa05323 MMP1 0.5372
Hematopoietic cell lineage_Homo sapiens_hsa04640 FLT3 0.5385
Salivary secretion_Homo sapiens_hsa04970 PRKCA 0.5385
Melanogenesis_Homo sapiens_hsa04916 PRKCA, TYR 1.154
Toll-like receptor signaling pathway_Homo sapiens_hsa04620 PIK3CA, PIK3CB 1.1278
Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 CSNK2A1 0.5385
Insulin secretion_Homo sapiens_hsa04911 PRKCA 0.5471
Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142 PIK3CA, PIK3CB 1.1388
T cell receptor signaling pathway_Homo sapiens_hsa04660 PIK3CA, PIK3CB 1.1388
Peroxisome_Homo sapiens_hsa04146 XDH 0.5532
Aldosterone synthesis and secretion_Homo sapiens_hsa04925 PRKCA 0.5566
Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 PRKCA, PTGS2 1.154
Pancreatic secretion_Homo sapiens_hsa04972 CA2, PRKCA 1.182
Morphine addiction_Homo sapiens_hsa05032 ADORA1, PRKCA 1.22
Leishmaniasis_Homo sapiens_hsa05140 PTGS2 0.5926
GABAergic synapse_Homo sapiens_hsa04727 SRC, PRKCA 1.2384
Adipocytokine signaling pathway_Homo sapiens_hsa04920 PPARA 0.5972
Thyroid hormone synthesis_Homo sapiens_hsa04918 PRKCA 0.5948
p53 signaling pathway_Homo sapiens_hsa04115 CDK6 0.5996
Long-term potentiation_Homo sapiens_hsa04720 PRKCA 0.6107
Amphetamine addiction_Homo sapiens_hsa05031 PRKCA 0.608
Renin secretion_Homo sapiens_hsa04924 ADORA1 0.6135
Shigellosis_Homo sapiens_hsa05131 SRC 0.6135
B cell receptor signaling pathway_Homo sapiens_hsa04662 PIK3CA, PIK3CB 1.3711
Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 RORC 0.6135
Complement and coagulation cascades_Homo sapiens_hsa04610 F10, F3 1.3201
Gastric acid secretion_Homo sapiens_hsa04971 CA2, PRKCA 1.3685
Inositol phosphate metabolism_Homo sapiens_hsa00562 PIK3CA, PIK3CB 1.3893
Bile secretion_Homo sapiens_hsa04976 ABCB1, CA2 1.3893
Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 SRC, MET 1.4157
Long-term depression_Homo sapiens_hsa04730 PRKCA, IGF1R 1.5046
Vibrio cholerae infection_Homo sapiens_hsa05110 PRKCA 0.6994
Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 BCL2 0.6994
Malaria_Homo sapiens_hsa05144 MET 0.7089
Glycerolipid metabolism_Homo sapiens_hsa00561 AKR1B10, AKR1B1 1.5139
Endometrial cancer_Homo sapiens_hsa05213 PIK3CA, PIK3CB 1.6041
Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 AOX1 0.7138
Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 TUBB3, PRKCA 1.567
Sphingolipid metabolism_Homo sapiens_hsa00600 GBA2 0.719
Drug metabolism - other enzymes_Homo sapiens_hsa00983 XDH 0.7242
ABC transporters_Homo sapiens_hsa02010 ABCB1 0.7387
Carbohydrate digestion and absorption_Homo sapiens_hsa04973 PIK3CA, PIK3CB 1.6704
Type II diabetes mellitus_Homo sapiens_hsa04930 PIK3CA, PIK3CB 1.643
Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 PRKCA, ESR1 1.6546
African trypanosomiasis_Homo sapiens_hsa05143 PRKCA 0.8248
Galactose metabolism_Homo sapiens_hsa00052 AKR1B10, AKR1B1 1.9574
Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 FUT7 0.8713
Linoleic acid metabolism_Homo sapiens_hsa00591 ALOX15, CYP1A2 1.9743
Tyrosine metabolism_Homo sapiens_hsa00350 AOX1, TYR 1.8604
Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 AOX1 0.8918
Fructose and mannose metabolism_Homo sapiens_hsa00051 AKR1B10, AKR1B1 1.9255
Pentose and glucuronate interconversions_Homo sapiens_hsa00040 AKR1B10, AKR1B1 1.8419
Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 FUT7 0.9285
Circadian rhythm_Homo sapiens_hsa04710 RORC 0.8814
Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 CA2, CA4 2.1288
Collecting duct acid secretion_Homo sapiens_hsa04966 CA2 0.9179
Other glycan degradation_Homo sapiens_hsa00511 GBA2 1.066
Folate biosynthesis_Homo sapiens_hsa00790 ALPL 1.154
Caffeine metabolism_Homo sapiens_hsa00232 CYP1A2, XDH 3.2765
Vitamin B6 metabolism_Homo sapiens_hsa00750 AOX1 1.458


Target Exprsssion in Healthy Human Tissues (protein & mRNA level)

Protein expression data was from the "Human Proteome Map" dataset
mRNA expression data was from the "GTEx" dataset



Average Target Expression (Fold Change) in Multiple Disease Conditions

Fold Change with Corresponding Normal Samples
Click each cell within the heatmap to access gene expression of individual patient samples
Data Section
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1. General Information of Prescription  
2. Putative Targets  
3. Activity & References for Filtering Putative Targets  
4. GO & Pathway  
5. Targets Expression Levels in Healthy Donor (mRNA Level)  
6. Targets Expression Levels in Healthy Donor (Protein Level)