Prescription Description
| Prescription ID | TCMF1068 |
| Pinyin Name | Zhi Kang Pian |
| Chinese Name | 痔康片 |
| English Name | Zhi Kang Tablet |
| Function Description | 痔疮出血, 肿痛 |
| Indications | Hemorrhoids |
| Disease ICD-11 Category |
DB60 [Haemorrhoids, 痔
]; |
| Human Tissues Associated with Indication | Large Intestine |
| Reference | Chinese pharmacopoeia (2015) |
| Reference Book/link | ISBN 978-7-5067-7337-9 |
Prescription Components
| Component ID | Latin Name | Chinese Name | Component Quantity | Barcode |
|---|---|---|---|---|
| TCMH2238 | Siegesbeckiae herba | 豨莶草 | TCMH2238 | GQ434487 |
| TCMH1127 | Lonicera japonica | 金银花 | TCMH1127 | ITSAI3881-14 |
| TCMH938 | Sophora japonica | 槐花 | TCMH938 | ITSAN2377-14 |
| TCMH463 | Sanguisorba officinalis | 地榆炭 | TCMH463 | GENG545-14, GBVT2403-13 |
| TCMH986 | Scutellaria baicalensis | 黄芩 | TCMH986 | ITSAP4211-14 |
| TCMH363 | Rheum officinale | 大黄 | TCMH363 | ITSAJ4685-14 |
Targeted Human Proteins by the Ingredients of Prescription
| Target ID | Gene Symbol | Target Name | Target Class | Uniprot ID |
|---|---|---|---|---|
| TCMT100 | TTR | Transthyretin | Unclassified | P02766 |
| TCMT102 | ACP1 | Low molecular weight phosphotyrosine protein phosphatase | Hydrolase | P24666 |
| TCMT103 | PTPRF | Receptor-type tyrosine-protein phosphatase F (LAR) | Hydrolase | P10586 |
| TCMT112 | ADORA3 | Adenosine A3 receptor | GPCR | P0DMS8 |
| TCMT114 | CNR2 | Cannabinoid CB2 receptor | GPCR | P34972 |
| TCMT115 | CNR1 | Cannabinoid CB1 receptor | GPCR | P21554 |
| TCMT127 | PARP1 | Poly [ADP-ribose] polymerase-1 | Transferase | P09874 |
| TCMT128 | TNKS2 | Tankyrase-2 | Transferase | Q9H2K2 |
| TCMT129 | TNKS | Tankyrase-1 | Transferase | O95271 |
| TCMT130 | ALOX5 | Arachidonate 5-lipoxygenase | Oxidoreductase | P09917 |
Showing 1 to 10 of 114 entries
Targeted Pathogenic Microbes by the Ingredients of Prescription
| Target ID | Target Name |
|---|---|
| TCMT1170 | Enterobacter cloacae |
| TCMT1175 | Human immunodeficiency virus |
| TCMT1176 | Streptococcus pneumoniae |
| TCMT1178 | Actinomyces viscosus |
| TCMT1181 | Mycobacterium tuberculosis H37Ra |
| TCMT1182 | Streptococcus sanguinis |
| TCMT1183 | Candida albicans SC5314 |
| TCMT1189 | Pseudomonas fluorescens |
| TCMT1190 | Plasmodium falciparum (isolate FcB1 / Columbia) |
| TCMT1191 | Bacillus megaterium |
Showing 1 to 10 of 68 entries
Gene Ontology Associated to Targeted Human Proteins
| GO Term | GO Name | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|---|
| [BP] GO:0000302 | response to reactive oxygen species | AKR1B1, AXL, BCL2, CYP1B1, MMP9, SRC | 2.27372 |
| [BP] GO:0001503 | ossification | ALOX15, ALPL, BCL2, MMP2, MMP9 | 2.18449 |
| [BP] GO:0001666 | response to hypoxia | ADORA1, BCL2, CYP1A1, HSD11B2, MMP2, PPARA, PTGS2, SRC | 3.00858 |
| [BP] GO:0001676 | long-chain fatty acid metabolic process | ALOX15, CBR1, CYP1A1, CYP1A2, CYP1B1, PTGS1, PTGS2 | 4.54362 |
| [BP] GO:0001932 | regulation of protein phosphorylation | ADORA1, ALOX15, APP, AR, BCL2, FABP4, FLT3, HTR2A, HTR2B, HTR2C, IGF1R, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH | 3.11689 |
| [BP] GO:0001934 | positive regulation of protein phosphorylation | ADORA1, ALOX15, APP, AR, BCL2, FLT3, HTR2A, HTR2B, HTR2C, KDR, MMP9, PIK3CA, PIK3CB, PTGS2, SRC, XDH | 3.8809 |
| [BP] GO:0002009 | morphogenesis of an epithelium | AR, BCL2, CA2, CA9, ESR1, MET, SRC | 2.05411 |
| [BP] GO:0002237 | response to molecule of bacterial origin | ALPL, AXL, CNR1, CNR2, CYP1A1, CYP1A2, PTGS2, SRC | 2.66866 |
| [BP] GO:0002682 | regulation of immune system process | ADORA1, ALOX15, APP, AXL, BCL2, CA2, CNR1, CNR2, CYP19A1, ESR1, ESRRA, MMP12, MMP2, PIK3CA, PIK3CB, PTPRS, SRC | 2.15795 |
| [BP] GO:0003006 | developmental process involved in reproduction | ALPL, AR, AXL, BCL2, CYP19A1, ESR1, ESRRB, HSD17B2, PGR, PTGS2, SRC | 2.63374 |
Showing 1 to 10 of 366 entries
KEGG Pathways Associated to Targeted Human Proteins
| KEGG Pathway ID | Enriched Genes | Log10 Adjusted P-value |
|---|---|---|
| ABC transporters_Homo sapiens_hsa02010 | ABCB1 | 0.6992 |
| Acute myeloid leukemia_Homo sapiens_hsa05221 | PIK3CA, FLT3, PIM1, PIK3CB | 3.4035 |
| Adherens junction_Homo sapiens_hsa04520 | CSNK2A1, SRC, MET, IGF1R | 3.0453 |
| Adipocytokine signaling pathway_Homo sapiens_hsa04920 | PPARA | 0.5563 |
| Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | PIK3CA, BCL2, PIK3CB | 1.4241 |
| AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | PIK3CA, MMP2, BCL2, PIM1, PIK3CB | 3.5759 |
| Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | HSD11B2, PIK3CA, PIK3CB, NR3C2 | 3.9158 |
| Alzheimer's disease_Homo sapiens_hsa05010 | APP | 0.3087 |
| Amoebiasis_Homo sapiens_hsa05146 | PIK3CA, PIK3CB | 1.06 |
| AMPK signaling pathway_Homo sapiens_hsa04152 | PIK3CA, PIK3CB, IGF1R | 1.5714 |
Showing 1 to 10 of 153 entries
Target Exprsssion in Healthy Human Tissues (protein & mRNA level)
Protein expression data was from the "Human Proteome Map" datasetmRNA expression data was from the "GTEx" dataset
Average Target Expression (Fold Change) in Multiple Disease Conditions
Fold Change with Corresponding Normal SamplesClick each cell within the heatmap to access gene expression of individual patient samples